Shenoy MM, De A, Shah B, Das A, Saraswat A, Lahiri K, Yadav S, Sarda A, Chakraborty D, J D, Kamat S, Doshi Y, Gonsalves N, Choudhary A, Dhoot D, Mahadkar N, Bhushan S, Gadkari R, Barkate H

Drug Design, Development and Therapy 2023, 17:3033-3034

Published Date: 28 September 2023

Review

Lurasidone for the Treatment of Schizophrenia: Design, Development, and Place in Therapy

Miura I, Horikoshi S, Ichinose M, Suzuki Y, Watanabe K

Drug Design, Development and Therapy 2023, 17:3023-3031

Published Date: 28 September 2023

Review

Macro, Micro, and Nano-Inspired Bioactive Polymeric Biomaterials in Therapeutic, and Regenerative Orofacial Applications

Atia GA, Shalaby HK, Roomi AB, Ghobashy MM, Attia HA, Mohamed SZ, Abdeen A, Abdo M, Fericean L, Bănățean Dunea I, Atwa AM, Hasan T, Mady W, Abdelkader A, Ali SA, Habotta OA, Azouz RA, Malhat F, Shukry M, Foda T, Dinu S

Drug Design, Development and Therapy 2023, 17:2985-3021

Published Date: 27 September 2023

Original Research

How Tongxie-Yaofang Regulates Intestinal Synaptic Plasticity by Activating Enteric Glial Cells and NGF/TrkA Pathway in Diarrhea-Predominant Irritable Bowel Syndrome Rats

Lu X, Zhang S

Drug Design, Development and Therapy 2023, 17:2969-2983

Published Date: 27 September 2023

Review

Escitalopram Personalized Dosing: A Population Pharmacokinetics Repository Method

Liu X, Ju G, Yang W, Chen L, Xu N, He Q, Zhu X, Ouyang D

Drug Design, Development and Therapy 2023, 17:2955-2967

Published Date: 27 September 2023

Clinical Trial Report

Remimazolam vs Etomidate: Haemodynamic Effects in Hypertensive Elderly Patients Undergoing Non-Cardiac Surgery

Chen J, Zou X, Hu B, Yang Y, Wang F, Zhou Q, Shen M

Drug Design, Development and Therapy 2023, 17:2943-2953

Published Date: 27 September 2023

Original Research

Effect of Intraoperative Dexmedetomidine Use on Postoperative Delirium in the Elderly After Laryngectomy: A Randomized Controlled Clinical Trial

Liu W, Wang Y, Chen K, Ye M, Lu W, Chen K, Shen X

Drug Design, Development and Therapy 2023, 17:2933-2941

Published Date: 22 September 2023

Corrigendum

Neuroprotective Effects of Melatonin and Celecoxib against Ethanol-Induced Neurodegeneration: A Computational and Pharmacological Approach [Corrigendum]

Al Kury LT, Zeb A, Abidin ZU, Irshad N, Malik I, Alvi AM, Khalil AAK, Ahmad S, Faheem M, Khan AU, Shah FA, Li S

Drug Design, Development and Therapy 2023, 17:2931-2932

Published Date: 22 September 2023

Review

Withaferin A: A Dietary Supplement with Promising Potential as an Anti-Tumor Therapeutic for Cancer Treatment - Pharmacology and Mechanisms

Xing Z, Su A, Mi L, Zhang Y, He T, Qiu Y, Wei T, Li Z, Zhu J, Wu W

Drug Design, Development and Therapy 2023, 17:2909-2929

Published Date: 21 September 2023

Original Research

Efficacy of Super-Bioavailable Itraconazole and Conventional Itraconazole at Different Dosing Regimens in Glabrous Tinea Infection - A Randomized Clinical Trial

Shenoy MM, De A, Shah B, Das A, Saraswat A, Lahiri K, Yadav S, Sarda A, Chakraborty D, J D, Kamat S, Doshi Y, Gonsalves N, Choudhary A, Dhoot D, Mahadkar N, Bhushan S, Gadkari R, Barkate H

Drug Design, Development and Therapy 2023, 17:2899-2908

Published Date: 21 September 2023

Retraction

Impact of Postoperative Dexmedetomidine Infusion on Incidence of Delirium in Elderly Patients Undergoing Major Elective Noncardiac Surgery: a Randomized Clinical Trial [Retraction]

Sun Y, Jiang M, Ji Y, Sun Y, Liu Y, Shen W

Drug Design, Development and Therapy 2023, 17:2897-2898

Published Date: 20 September 2023

Original Research

Efficacy and Safety of Different Doses of Remimazolam Tosilate Applied in Upper Gastrointestinal Endoscopy: A Prospective Randomized Controlled Double-Blind Trial

Cui X, Cheng Z, Li H, Zhang X, Luan H, Zhao Z, Zhu P

Drug Design, Development and Therapy 2023, 17:2889-2896

Published Date: 20 September 2023

Original Research

The Efficacy and Safety of Remimazolam Besylate Combined with Esketamine for Outpatient Colonoscopy: A Prospective, Randomized, Controlled Clinical Trial

Li W, Zhao J, Hao R, Wang S, Chen M, Liu H, Qi L, Hao Z

Drug Design, Development and Therapy 2023, 17:2875-2887

Published Date: 18 September 2023

Review

Faricimab: Transforming the Future of Macular Diseases Treatment - A Comprehensive Review of Clinical Studies

Panos GD, Lakshmanan A, Dadoukis P, Ripa M, Motta L, Amoaku WM

Drug Design, Development and Therapy 2023, 17:2861-2873

Published Date: 18 September 2023

Letter

The Effect of Low-Dose Esketamine on Postoperative Neurocognitive Dysfunction in Elderly Patients Undergoing General Anesthesia for Gastrointestinal Tumors: A Randomized Controlled Trial [Letter]

Lin Y, Jiang M

Drug Design, Development and Therapy 2023, 17:2859-2860

Published Date: 15 September 2023

Original Research

Integrating Network Pharmacology and Component Analysis to Study the Potential Mechanisms of Qi-Fu-Yin Decoction in Treating Alzheimer’s Disease

Lei X, Xu H, Wang Y, Gao H, Zhao D, Zhang J, Zhu Z, Zuo K, Liu Y, Li X, Zhang N

Drug Design, Development and Therapy 2023, 17:2841-2858

Published Date: 14 September 2023

Original Research

Thalidomide Alleviates Apoptosis, Oxidative Damage and Inflammation Induced by Pemphigus Vulgaris IgG in HaCat Cells and Neonatal Mice Through MyD88

Luan C, Lu Z, Chen J, Chen M, Zhao R, Li X

Drug Design, Development and Therapy 2023, 17:2821-2839

Published Date: 12 September 2023

Original Research

Deciphering the Mechanism of Xijiao Dihuang Decoction in Treating Psoriasis by Network Pharmacology and Experimental Validation

Guo Y, Gan H, Xu S, Zeng G, Xiao L, Ding Z, Zhu J, Xiong X, Fu Z

Drug Design, Development and Therapy 2023, 17:2805-2819

Published Date: 12 September 2023

Original Research

Pharmacological Activity of Matrine in Inhibiting Colon Cancer Cells VM Formation, Proliferation, and Invasion by Downregulating Claudin-9 Mediated EMT Process and MAPK Signaling Pathway

Du Q, Lin Y, Ding C, Wu L, Xu Y, Feng Q

Drug Design, Development and Therapy 2023, 17:2787-2804

Published Date: 11 September 2023

Original Research

Melatonin Attenuates Sepsis-Induced Acute Lung Injury via Inhibiting Excessive Mitophagy

Ling J, Yu S, Xiong F, Xu T, Li S

Drug Design, Development and Therapy 2023, 17:2775-2786

Published Date: 11 September 2023

Review

Recent Advances in the Nanoshells Approach for Encapsulation of Single Probiotics

Chen C, Zhu Z

Drug Design, Development and Therapy 2023, 17:2763-2774

Published Date: 8 September 2023

Original Research

Isoliensinine Attenuates Renal Fibrosis and Inhibits TGF-β1/Smad2/3 Signaling Pathway in Spontaneously Hypertensive Rats

Yao M, Lian D, Wu M, Zhou Y, Fang Y, Zhang S, Zhang W, Yang Y, Li R, Chen H, Chen Y, Shen A, Peng J

Drug Design, Development and Therapy 2023, 17:2749-2762

Published Date: 7 September 2023

Letter

More Smart Use of Direct Oral Anticoagulants in Geriatric Patients [Letter]

Zhu LL, Zhou Q

Drug Design, Development and Therapy 2023, 17:2747-2748

Published Date: 6 September 2023

Original Research

Exploring the Mechanisms of Modified Bu-Shen-Yi-Qi Decoction for COPD-Related Osteoporosis Therapy via Transcriptomics and Network Pharmacology Approach

Zhong Y, Wang B, Chen W, Zhang H, Sun J, Dong J

Drug Design, Development and Therapy 2023, 17:2727-2745

Published Date: 6 September 2023

Perspectives

The Coming of Age of AI/ML in Drug Discovery, Development, Clinical Testing, and Manufacturing: The FDA Perspectives

Niazi SK

Drug Design, Development and Therapy 2023, 17:2691-2725

Published Date: 6 September 2023

Review

Inhibition of LPA-LPAR1 and VEGF-VEGFR2 Signaling in IPF Treatment

Luo YL, Li Y, Zhou W, Wang SY, Liu YQ

Drug Design, Development and Therapy 2023, 17:2679-2690

Published Date: 2 September 2023

Original Research

Effects of Remimazolam and Propofol on Emergence Agitation in Elderly Patients Undergoing Hip Replacement: A Clinical, Randomized, Controlled Study

Duan J, Ju X, Wang X, Liu N, Xu S, Wang S

Drug Design, Development and Therapy 2023, 17:2669-2678

Published Date: 1 September 2023

Original Research

The Effect of Dihydromyricetin on the Pharmacokinetics of Fluconazole in Sprague-Dawley Rat Plasma, Based on High-Performance Liquid Chromatography–Tandem Mass Spectrometry

Liu H, Dong H, Guo L, Jin Y, Liu L

Drug Design, Development and Therapy 2023, 17:2657-2667

Published Date: 31 August 2023

Review

Recent Research Advances in Nano-Based Drug Delivery Systems for Local Anesthetics

Ma H, Pan Z, Lai B, Zan C, Liu H

Drug Design, Development and Therapy 2023, 17:2639-2655

Published Date: 30 August 2023

Review

Coenzyme Q10 Stimulate Reproductive Vatality

Nie X, Dong X, Hu Y, Xu F, Hu C, Shu C

Drug Design, Development and Therapy 2023, 17:2623-2637

Published Date: 30 August 2023

Original Research

Effect of Dexmedetomidine and Two Different Doses of Esketamine Combined Infusion on the Quality of Recovery in Patients Undergoing Modified Radical Mastectomy for Breast Cancer - A Randomised Controlled Study

Huang Z, Liu N, Hu S, Ju X, Xu S, Wang S

Drug Design, Development and Therapy 2023, 17:2613-2621

Published Date: 28 August 2023

Original Research

Comprehensive Analysis to Identify Rh Family C Glycoprotein (RHCG) as the Causative Gene for Psoriasis and Search for Alternative Treatment Modalities

Zhang Q, Liu J, Yao D, Shi JX, Liu YJ, Wei YG, Guo S

Drug Design, Development and Therapy 2023, 17:2593-2611

Published Date: 28 August 2023

Review

Oral Isotretinoin and Its Uses in Dermatology: A Review

Paichitrojjana A, Paichitrojjana A

Drug Design, Development and Therapy 2023, 17:2573-2591

Published Date: 25 August 2023

Review

Tracking Research on Hemoglobin-Based Oxygen Carriers: A Scientometric Analysis and In-Depth Review

Zhang Q, Ma YX, Dai Z, Zhang B, Liu SS, Li WX, Fu CQ, Wang QM, Yin W

Drug Design, Development and Therapy 2023, 17:2549-2571

Published Date: 24 August 2023

Original Research

New Target for Minoxidil in the Treatment of Androgenetic Alopecia

Shen Y, Zhu Y, Zhang L, Sun J, Xie B, Zhang H, Song X

Drug Design, Development and Therapy 2023, 17:2537-2547

Published Date: 24 August 2023

Original Research

Recombinant Neorudin for the Prevention of Deep-Vein Thrombosis After Spinal-Cord Injury

Liu YB, Liu Y, Zhang L, Zhou XC, Ren BY, Zheng C, Hao CH, Wang WT, Xia X, Zhou GQ, Wu CT, Jin JD

Drug Design, Development and Therapy 2023, 17:2523-2535

Published Date: 23 August 2023

Original Research

ABCG2 Gene Polymorphisms May Affect the Bleeding Risk in Patients on Apixaban and Rivaroxaban

Kim H, Song TJ, Yee J, Kim DH, Park J, Gwak HS

Drug Design, Development and Therapy 2023, 17:2513-2522

Published Date: 23 August 2023

Original Research

Galangin Attenuates Myocardial Ischemic Reperfusion-Induced Ferroptosis by Targeting Nrf2/Gpx4 Signaling Pathway

Yang T, Liu H, Yang C, Mo H, Wang X, Song X, Jiang L, Deng P, Chen R, Wu P, Chen A, Yan J

Drug Design, Development and Therapy 2023, 17:2495-2511

Published Date: 22 August 2023

Original Research

Ursolic Acid Ameliorated Neuronal Damage by Restoring Microglia-Activated MMP/TIMP Imbalance in vitro

Qiu L, Wang Y, Wang Y, Liu F, Deng S, Xue W, Wang Y

Drug Design, Development and Therapy 2023, 17:2481-2493

Published Date: 22 August 2023

Original Research

Integrating Network Pharmacology and Experimental Validation to Explore the Effects and Mechanisms of Qinghao Biejia Decoction and Its Active Compound Artemisinin B Against Non-Small-Cell Lung Cancer

Ye Y, Yang Y, Yan L, Zhou L, Yu S, Du Q, Dong X, Yuan Q, Shan L, Guo L

Drug Design, Development and Therapy 2023, 17:2461-2479

Published Date: 22 August 2023

Response to Letter

Evaluation of the Effect of New Multimodal Analgesia Regimen for Cardiac Surgery: A Prospective, Randomized Controlled, Single-Center Clinical Study [Response to Letter]

Jin L, Guo K

Drug Design, Development and Therapy 2023, 17:2457-2460

Published Date: 22 August 2023

Letter

Critical Response to Article “Network Pharmacology and Experimental Validation to Explore the Effect and Mechanism of Kanglaite Injection Against Triple-Negative Breast Cancer” [Letter]

Dany F, Nikmah UA, Lienggonegoro LA

Drug Design, Development and Therapy 2023, 17:2455-2456

Published Date: 21 August 2023

Original Research

In vitro and in vivo Efficacies of Novel Harmine Derivatives in the Treatment of Cystic Echinococcosis

Chen B, Yan M, Gao H, Ma Q, Li L, Lü G, Gong Y, Wen L, Xu S, Wang J, Zhao J

Drug Design, Development and Therapy 2023, 17:2441-2454

Published Date: 21 August 2023

Clinical Trial Report

Intravenous Lidocaine Decreased the Median Effective Concentration of Sufentanil for Tracheal Intubation in Obese Patients

Jia D, Yuan X, He C, Tu F

Drug Design, Development and Therapy 2023, 17:2431-2439

Published Date: 21 August 2023

Clinical Trial Report

Pharmacokinetic Study of Enteric-Coated Sustained-Release Aspirin Tablets in Healthy Chinese Participants

Cong D, Qi W, Liu X, Xu X, Dong L, Xue W, Li K

Drug Design, Development and Therapy 2023, 17:2421-2429

Published Date: 18 August 2023

Original Research

An Exosome-Based Therapeutic Strategy Targeting Neuroinflammation in Alzheimer’s Disease with Berberine and Palmatine

Zhao X, Ge P, Lei S, Guo S, Zhou P, Zhao L, Qi Y, Wei X, Wu W, Wang N, Guo R, Yang N, Xiao Q, Zhang Q, Zhu H

Drug Design, Development and Therapy 2023, 17:2401-2420

Published Date: 17 August 2023

Original Research

Paroxetine Attenuates Chondrocyte Pyroptosis and Inhibits Osteoclast Formation by Inhibiting NF-κB Pathway Activation to Delay Osteoarthritis Progression

Zheng X, Qiu J, Gao N, Jiang T, Li Z, Zhang W, Gong Y, Hong Z, Hong H

Drug Design, Development and Therapy 2023, 17:2383-2399

Published Date: 16 August 2023

Original Research

Comparative Pharmacokinetics and Bioequivalence Evaluation of Two Formulations of Pramipexole Dihydrochloride Extended-Release Tablets in Healthy Chinese Subjects Under Fasted and Fed States: A Randomized, Open-Label, Single-Dose, Two-Period Crossover Clinical Trial

Yang L, Zhang L, Luo Z

Drug Design, Development and Therapy 2023, 17:2369-2381

Published Date: 15 August 2023

Original Research

Renzhu Ointment Regulates L-Type Voltage-Dependent Calcium Channel in Mice Model of Senna-Induced Diarrhea by Transdermal Administration

Zhong L, Cao X, Li L, He Y, Liu Y, Chen W, Yang F, Xiao N, Zhang J, He H

Drug Design, Development and Therapy 2023, 17:2355-2368

Published Date: 11 August 2023

Letter

Evaluation of the Effect of New Multimodal Analgesia Regimen for Cardiac Surgery: A Prospective, Randomized Controlled, Single-Center Clinical Study [Letter]

Chen PS, Xue FS, Li CW

Drug Design, Development and Therapy 2023, 17:2353-2354

Published Date: 10 August 2023

Original Research

Network Pharmacology and Molecular Docking Reveal the Mechanism of Isodon ternifolius (D. Don) Kudo Against Liver Fibrosis

Deng J, Qin L, Zhou Z

Drug Design, Development and Therapy 2023, 17:2335-2351

Published Date: 7 August 2023

Review

Profile of Relugolix in the Management of Advanced Hormone-Sensitive Prostate Cancer: Design, Development, and Place in Therapy

Tatenuma T, Miyamoto H

Drug Design, Development and Therapy 2023, 17:2325-2333

Published Date: 4 August 2023

Original Research

Changes in Drug Clinical Trials of Thyroid Diseases in China, 2009–2022

Li C, Hao J, Wang C, Yang J, Zheng Y, Zhang K, Hui W, Meng X, Gao J, Li W, Tang YD

Drug Design, Development and Therapy 2023, 17:2315-2324

Published Date: 3 August 2023

Original Research

A Phase I Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Novel Intravenous Formulation of Meloxicam (QP001) in Healthy Chinese Subjects

Ma J, Huang J, Zou C, Wu Q, Xie J, Zhang X, Yang X, Yang S, Wu Z, Jiang Y, Yu S, Zhang X, Yang G, Li M

Drug Design, Development and Therapy 2023, 17:2303-2313

Published Date: 3 August 2023

Original Research

Dispelling Dampness, Relieving Turbidity and Dredging Collaterals Decoction, Attenuates Potassium Oxonate-Induced Hyperuricemia in Rat Models

Liu HB, Yang M, Li W, Luo T, Wu Y, Huang XY, Zhang YL, Liu T, Luo Y

Drug Design, Development and Therapy 2023, 17:2287-2301

Published Date: 2 August 2023

Original Research

Dioscin Ameliorates Experimental Autoimmune Thyroiditis via the mTOR and TLR4/NF-κB Signaling

Zhang C, Zhang Q, Qin L, Yan Z, Wu L, Liu T

Drug Design, Development and Therapy 2023, 17:2273-2285

Published Date: 2 August 2023

Original Research

Optimal Teicoplanin Dosage Regimens in Critically Ill Patients: Population Pharmacokinetics and Dosing Simulations Based on Renal Function and Infection Type

Wang Y, Yao F, Chen S, Ouyang X, Lan J, Wu Z, Wang Y, Chen J, Wang X, Chen C

Drug Design, Development and Therapy 2023, 17:2259-2271

Published Date: 1 August 2023

Original Research

Zhiqiao Gancao Decoction Ameliorates Hyperalgesia in Lumbar Disc Herniation via the CCL2/CCR2 Signaling Pathway

Huang Z, Lu B, Zhang X, Wang J, Cai X, Liu Y, Mo J, Li Y, Xu B, Shen X

Drug Design, Development and Therapy 2023, 17:2239-2257

Published Date: 28 July 2023

Original Research

The First Discovery of a Microstructure in Black Plaster and Its Performance Characterization

Li Y, Zhu T, Liang J, Wu Y, Guan X, Liu T, Lü S, Li Y, Wang Y, Ping Y

Drug Design, Development and Therapy 2023, 17:2223-2237

Published Date: 28 July 2023

Original Research

Elucidating the Mechanism of Agrimonolide in Treating Colon Cancer Based on Network Pharmacology

Yu L, Gai Y

Drug Design, Development and Therapy 2023, 17:2209-2222

Published Date: 27 July 2023

Review

Review of the Protective Mechanism of Paeonol on Cardiovascular Disease

Yang C, Cheng J, Zhu Q, Pan Q, Ji K, Li J

Drug Design, Development and Therapy 2023, 17:2193-2208

Published Date: 26 July 2023

Original Research

Probiotics Alleviate Chemotherapy-Associated Intestinal Mucosal Injury via the TLR4–NFκB Signaling Pathway

Li X, Hu B, Zheng J, Pan Z, Cai Y, Zhao M, Jin X, Li ZQ

Drug Design, Development and Therapy 2023, 17:2183-2192

Published Date: 25 July 2023

Original Research

A Bibliometric Analysis of Mesenchymal Stem Cell-Derived Exosomes in Acute Lung Injury/Acute Respiratory Distress Syndrome from 2013 to 2022

Zhou W, Hu S, Wu Y, Xu H, Zhu L, Deng H, Wang S, Chen Y, Zhou H, Lv X, Li Q, Yang H

Drug Design, Development and Therapy 2023, 17:2165-2181

Published Date: 25 July 2023

Original Research

Investigation of the Mechanisms and Experimental Verification of Yulin Formula in the Treatment of Diminished Ovarian Reserve via Network Pharmacology

Wang R, Zhao Y, Miao C, Chen Y, Ren N, Yang L, Cheng W, Zhang Q, Fang X

Drug Design, Development and Therapy 2023, 17:2147-2163

Published Date: 24 July 2023

Original Research

Comparison of the Pharmacokinetics, Safety, and Tolerability of Two Empagliflozin Formulations in Healthy Korean Subjects

Jiang X, Bae S, Yoon DY, Park SJ, Oh J, Cho JY, Yu KS

Drug Design, Development and Therapy 2023, 17:2137-2145

Published Date: 24 July 2023

Original Research

Bibliometric Analysis of Global Trends in Remimazolam-Related Research Over the Past 15 Years: Compared with Propofol

Hu X, Wang B, Hu L, Han D, Wu J

Drug Design, Development and Therapy 2023, 17:2119-2135

Published Date: 20 July 2023

Original Research

Astragalus Polysaccharide Ameliorates Renal Inflammatory Responses in a Diabetic Nephropathy by Suppressing the TLR4/NF-κB Pathway

Guo M, Gao J, Jiang L, Dai Y

Drug Design, Development and Therapy 2023, 17:2107-2118

Published Date: 19 July 2023

Original Research

Dendritic Cell-Derived Exosomes Driven Drug Co-Delivery Biomimetic Nanosystem for Effective Combination of Malignant Melanoma Immunotherapy and Gene Therapy

Lin J, Huang N, Li M, Zheng M, Wang Z, Zhang X, Gao H, Lao Y, Zhang J, Ding B

Drug Design, Development and Therapy 2023, 17:2087-2106

Published Date: 19 July 2023

Clinical Trial Report

Comparison of Dural Puncture Epidural, Epidural and Combined Spinal-Epidural Anesthesia for Cesarean Delivery: A Randomized Controlled Trial

Rao WY, Xu F, Dai SB, Mei Z, Chen XP, Lv CC, Liu CL, Ngan Kee W, Chen XZ

Drug Design, Development and Therapy 2023, 17:2077-2085

Published Date: 18 July 2023

Original Research

Design, Synthesis and Biological Evaluation of Glycosylated Derivatives of Silibinin as Potential Anti-Tumor Agents

Xi JJ, Cao Y, He RY, Zhang JK, Zhao YM, Tong Q, Bao JF, Dong YC, Zhuang RX, Huang JS, Chen Y, Liu SR

Drug Design, Development and Therapy 2023, 17:2063-2076

Published Date: 11 July 2023

Original Research

Phase I, Single-Dose Study to Assess the Pharmacokinetics and Safety of Suramin in Healthy Chinese Volunteers

Wu G, Zhou H, Lv D, Zheng R, Wu L, Yu S, Kai J, Xu N, Gu L, Hong N, Shentu J

Drug Design, Development and Therapy 2023, 17:2051-2061

Published Date: 11 July 2023

Review

Mapping Research Trends of Medications for Multidrug-Resistant Pulmonary Tuberculosis Based on the Co-Occurrence of Specific Semantic Types in the MeSH Tree: A Bibliometric and Visualization-Based Analysis of PubMed Literature (1966–2020)

Xu S, Fu Y, Xu D, Han S, Wu M, Ju X, Liu M, Huang DS, Guan P

Drug Design, Development and Therapy 2023, 17:2035-2049

Published Date: 10 July 2023

Original Research

Efficacy and Safety of Anlotinib in Overall and Disease-Specific Advanced Gynecological Cancer: A Real-World Study

Hong X, Qiu S, Wu X, Chen S, Chen X, Zhang B, He A, Xu Y, Wang J, Gao Y, Xu X, Sun L, Zhang Y, Xiang L, Zhou J, Guan Q, Zhu Y, Liu H, Xu H, Zhou Y, Chen B, Shen Y

Drug Design, Development and Therapy 2023, 17:2025-2033

Published Date: 6 July 2023

Review

SGLT1: A Potential Drug Target for Cardiovascular Disease

Zhao M, Li N, Zhou H

Drug Design, Development and Therapy 2023, 17:2011-2023

Published Date: 6 July 2023

Review

Antimalarial Drug Resistance: A Brief History of Its Spread in Indonesia

Fitri LE, Pawestri AR, Winaris N, Endharti AT, Khotimah ARH, Abidah HY, Huwae JTR

Drug Design, Development and Therapy 2023, 17:1995-2010

Published Date: 5 July 2023

Review

Profile of Lasmiditan in the Acute Treatment of Migraine in Adults: Design, Development, and Place in Therapy

Anderson CC, VanderPluym JH

Drug Design, Development and Therapy 2023, 17:1979-1993

Published Date: 3 July 2023

Review

Untapping the Potential of Astragaloside IV in the Battle Against Respiratory Diseases

Tan J, Yi J, Cao X, Wang F, Xie S, Dai A

Drug Design, Development and Therapy 2023, 17:1963-1978

Published Date: 3 July 2023

Editorial

Statistical Analysis in Clinical and Experimental Medical Research: Simplified Guidance for Authors and Reviewers

Panos GD, Boeckler FM

Drug Design, Development and Therapy 2023, 17:1959-1961

Published Date: 3 July 2023

Original Research

The Effect of Low-Dose Esketamine on Postoperative Neurocognitive Dysfunction in Elderly Patients Undergoing General Anesthesia for Gastrointestinal Tumors: A Randomized Controlled Trial

Ma J, Wang F, Wang J, Wang P, Dou X, Yao S, Lin Y

Drug Design, Development and Therapy 2023, 17:1945-1957

Published Date: 29 June 2023

Review

Informatics on Drug Repurposing for Breast Cancer

Zhou H, Liu H, Yu Y, Yuan X, Xiao L

Drug Design, Development and Therapy 2023, 17:1933-1943

Published Date: 28 June 2023

Review

Metformin: A Review of Potential Mechanism and Therapeutic Utility Beyond Diabetes

Dutta S, Shah RB, Singhal S, Dutta SB, Bansal S, Sinha S, Haque M

Drug Design, Development and Therapy 2023, 17:1907-1932

Published Date: 26 June 2023

Original Research

Antitumor Activity of Berberine by Activating Autophagy and Apoptosis in CAL-62 and BHT-101 Anaplastic Thyroid Carcinoma Cell Lines

Shi XZ, Zhao S, Wang Y, Wang MY, Su SW, Wu YZ, Xiong C

Drug Design, Development and Therapy 2023, 17:1889-1906

Published Date: 26 June 2023

Clinical Trial Report

Evaluation of Pharmacokinetics and Safety with Bioequivalence of Ibuprofen Sustained-Release Capsules of Two Formulations, in Chinese Healthy Volunteers: Bioequivalence Study

Huang C, Yin Z, Yang Y, Mo N, Yang H, Wang Y

Drug Design, Development and Therapy 2023, 17:1881-1888

Published Date: 23 June 2023

Retraction

Endoplasmic Reticulum Stress-Induced Autophagy Determines the Susceptibility of Melanoma Cells to Dabrafenib [Retraction]

Ji C, Zhang Z, Chen L, Zhou K, Li D, Wang P, Huang S, Gong T, Cheng B

Drug Design, Development and Therapy 2023, 17:1879-1880

Published Date: 22 June 2023

Original Research

Clinical Trials in Hypertrophic Cardiomyopathy Therapy: A Comprehensive Analysis of Trials Registered in Global Clinical Databases

Zhang H, Yu C, Cheng Y, Chen Z, Chen M, He W, Jin Z, Cai S, Yu L

Drug Design, Development and Therapy 2023, 17:1863-1877

Published Date: 21 June 2023

Original Research

Sanqi Qushi Granule Alleviates Proteinuria and Podocyte Damage in NS Rat: A Network Pharmacology Study and in vivo Experimental Validation

Wang L, Liu H, Wang Y, Hong X, Huang X, Han M, Wang D, Shan W, Li P, Gu H, Liu B, Bao K

Drug Design, Development and Therapy 2023, 17:1847-1861

Published Date: 19 June 2023

Original Research

Insight into Nephrotoxicity and Processing Mechanism of Arisaema erubescens (Wall.) Schott by Metabolomics and Network Analysis

Wang M, Yang N, Wu X, Zou T, Zheng J, Zhu H, Zhao C, Wang J

Drug Design, Development and Therapy 2023, 17:1831-1846

Published Date: 19 June 2023

Original Research

Luteolin Alleviates Liver Fibrosis in Rat Hepatic Stellate Cell HSC-T6: A Proteomic Analysis

Batudeligen, Han Z, Chen H, Narisu, Xu Y, Anda, Han G

Drug Design, Development and Therapy 2023, 17:1819-1829

Published Date: 17 June 2023

Original Research

Network Pharmacology Analysis of the Mechanisms Underlying the Therapeutic Effects of Yangjing Zhongyu Tang on Thin Endometrium

Zhang L, Li H, Zhang L, Zu Z, Xu D, Zhang J

Drug Design, Development and Therapy 2023, 17:1805-1818

Published Date: 17 June 2023

Original Research

Effect of Gabapentin-Fluoxetine Derivative GBP1F in a Murine Model of Depression, Anxiety and Cognition

Gohar A, Ali G, Rashid U, Rauf K, Arif M, Khan MS, Alkahramaan YM, Sewell RDE

Drug Design, Development and Therapy 2023, 17:1793-1803

Published Date: 16 June 2023

Review

CAR T Cell Therapy: Remedies of Current Challenges in Design, Injection, Infiltration and Working

Zhu Y, Feng J, Wan R, Huang W

Drug Design, Development and Therapy 2023, 17:1783-1792

Published Date: 14 June 2023

Original Research

Integrated Metabolomics and Network Pharmacology to Reveal the Mechanisms of Gandouling Tablets Against Copper-Overload-Induced Neuronal Injury in Rats with Wilson’s Disease

Chen L, Xu WY, Chen H, Han YQ, Zhang YT

Drug Design, Development and Therapy 2023, 17:1763-1782

Published Date: 13 June 2023

Original Research

Determination of the 50% and 95% Effective Dose of Remimazolam Combined with Propofol for Intravenous Sedation During Day-Surgery Hysteroscopy

Tan H, Lou AF, Wu JE, Chen XZ, Qian XW

Drug Design, Development and Therapy 2023, 17:1753-1761

Published Date: 13 June 2023

Clinical Trial Report

Effects of Different Injection Rates of Propofol on Postoperative Cognition in Elderly Patients Undergoing Laparoscopic Inguinal Hernia Repair

Li T, Han W, Yang X, Wang Y, Peng L, He L, Hu L, Liu J, Xia M, Wang S

Drug Design, Development and Therapy 2023, 17:1741-1752

Published Date: 13 June 2023

Clinical Trial Report

The Effect of Different Doses of Ciprofol in Patients with Painless Gastrointestinal Endoscopy

Chen L, Xie Y, Du X, Qin W, Huang L, Dai J, Qin K, Huang J

Drug Design, Development and Therapy 2023, 17:1733-1740

Published Date: 12 June 2023

Original Research

Sevoflurane Improves Ventricular Conduction by Exosomes Derived from Rat Cardiac Fibroblasts After Hypothermic Global Ischemia-Reperfusion Injury

Ma Y, Cao Y, Gao H, Tong R, Yi J, Zhang Z, Chen R, Pan Z

Drug Design, Development and Therapy 2023, 17:1719-1732

Published Date: 12 June 2023

Original Research

Efficacy and Safety of Ciprofol for Sedation/Anesthesia in Patients Undergoing Hysteroscopy: A Randomized, Parallel-Group, Controlled Trial

Lan H, Shan W, Wu Y, Xu Q, Dong X, Mei P, Duan G, You M, Jin L, Wu J

Drug Design, Development and Therapy 2023, 17:1707-1717

Published Date: 11 June 2023

Original Research

Perioperative Administration of Pregabalin and Esketamine to Prevent Chronic Pain After Breast Cancer Surgery: A Randomized Controlled Trial

Wang M, Xiong HP, Sheng K, Sun XB, Zhao XQ, Liu QR

Drug Design, Development and Therapy 2023, 17:1699-1706

Published Date: 8 June 2023

Original Research

Exploration of Artemisinin Against IgA Nephropathy via AKT/Nrf2 Pathway by Bioinformatics and Experimental Validation

Yang WG, Sun A, Zhu R, Liu N, He WJ, Liu LL

Drug Design, Development and Therapy 2023, 17:1679-1697

Published Date: 7 June 2023

Clinical Trial Report

Evaluation of the Effect of New Multimodal Analgesia Regimen for Cardiac Surgery: A Prospective, Randomized Controlled, Single-Center Clinical Study

Jin L, Liang Y, Yu Y, Miao P, Huang Y, Xu L, Wang H, Wang C, Huang J, Guo K

Drug Design, Development and Therapy 2023, 17:1665-1677

Published Date: 7 June 2023

Original Research

Metastasis Related Epithelial-Mesenchymal Transition Signature Predicts Prognosis and Response to Chemotherapy in Acute Myeloid Leukemia

Qu S, Huang X, Guo X, Zheng Z, Wei T, Chen B

Drug Design, Development and Therapy 2023, 17:1651-1663

Published Date: 6 June 2023

Original Research

A Novel Opioid-Sparing Analgesia Following Thoracoscopic Surgery: A Non-Inferiority Trial

Sun JJ, Xiang XB, Xu GH, Cheng XQ

Drug Design, Development and Therapy 2023, 17:1641-1650

Published Date: 6 June 2023

Original Research

Dexmedetomidine Improved Sleep Quality in the Intensive Care Unit After Laryngectomy

Huang J, Qin M, Lu W, Shen X

Drug Design, Development and Therapy 2023, 17:1631-1640

Published Date: 2 June 2023

Original Research

Tuo-Min-Ding-Chuan Decoction Alleviates Airway Inflammations in the Allergic Asthmatic Mice Model by Regulating TLR4-NLRP3 Pathway-Mediated Pyroptosis: A Network Pharmacology and Experimental Verification Study

Lyu M, Qin J, Huang S, Shao D, Huang G, Yang F, Gong X, Zhang S, Zhang Z, Wang J, Cui H

Drug Design, Development and Therapy 2023, 17:1613-1630

Published Date: 2 June 2023

Response to Letter

Thinkful of Icariin Induces Triple-Negative Breast Cancer Cell Apoptosis and Suppresses Invasion by Inhibiting the JNK/c-Jun Signaling Pathway [Response to Letter]

Gao S, Zhang X, Liu J, Lv Y, Shi W

Drug Design, Development and Therapy 2023, 17:1611-1612

Published Date: 29 May 2023

Original Research

0.5–5% Supramolecular Salicylic Acid Hydrogel is Safe for Long-Term Topical Application and Improves the Expression of Genes Related to Skin Barrier Homeostasis in Mice Models

Zhou C, Hua C, Liang Q, Al Rudaisat M, Chen S, Song Y, Zhu J, Cheng H

Drug Design, Development and Therapy 2023, 17:1593-1609

Published Date: 26 May 2023

Review

Profile of Luspatercept in the Treatment of Anemia in Adults with Non-Transfusion-Dependent β-Thalassemia (NTDT): Design, Development and Potential Place in Therapy

Musallam KM, Taher AT, Kattamis A, Kuo KH, Sheth S, Cappellini MD

Drug Design, Development and Therapy 2023, 17:1583-1591

Published Date: 25 May 2023

Original Research

Paeonol Promotes Reendothelialization After Vascular Injury Through Activation of c-Myc/VEGFR2 Signaling Pathway

Wang Y, Wang Z, Wu X, Zhu S, Guo Q, Jin Z, Chen Z, Zhang D, Hu W, Xu H, Shi L, Yang L, Wang Y

Drug Design, Development and Therapy 2023, 17:1567-1582

Published Date: 24 May 2023

Study Protocol

Effect of Flexible Half-Dose Gonadotropin-Releasing Hormone Antagonist Protocol on in vitro Fertilization Outcome in Predicted Normal Responder: A Study Protocol for a Multicentered, Randomized, Non-Inferiority, Parallel Controlled Trial

Ma YJ, Li MY, Song JY, Sun ZG

Drug Design, Development and Therapy 2023, 17:1557-1566

Published Date: 24 May 2023

Original Research

Prophylactic Norepinephrine and Phenylephrine Boluses to Prevent Postspinal Anesthesia Hypotension During Cesarean Section: A Randomized Sequential Allocation Dose-Finding Study

Guo L, Xu X, Qin R, Shi Y, Xue W, He L, Ma S, Chen Y

Drug Design, Development and Therapy 2023, 17:1547-1555

Published Date: 23 May 2023

Original Research

Network Pharmacology Study of Bioactive Components and Molecular Mechanisms of the Glycoside Fraction from Picrorhiza scrophulariiflora Against Experimental Colitis

Wu P, Chang C, Zhu G, Zhai L, Zhang X, Huan Q, Gao Z, Deng H, Liang Y, Xiao H

Drug Design, Development and Therapy 2023, 17:1531-1546

Published Date: 23 May 2023

Original Research

The Protective Effect of Selenium Nanoparticles in Osteoarthritis: In vitro and in vivo Studies

Li Y, Zhu S, Luo J, Tong Y, Zheng Y, Ji L, He Z, Jing Q, Huang J, Zhang Y, Bi Q

Drug Design, Development and Therapy 2023, 17:1515-1529

Published Date: 22 May 2023

Original Research

Fenofibrate Attenuates Renal Tubular Cell Apoptosis by Up-Regulating MCAD in Diabetic Kidney Disease

Tang C, Deng X, Qu J, Miao Y, Tian L, Zhang M, Li X, Sun B, Chen L

Drug Design, Development and Therapy 2023, 17:1503-1514

Published Date: 18 May 2023

Study Protocol

Effects of Empagliflozin on Gut Microbiota in Heart Failure with a Preserved Ejection Fraction: The Design of a Pragmatic Randomized, Open-Label Controlled Trial (EMPAGUM)

Guan XQ, Wang CH, Cheng P, Fu LY, Wu QJ, Cheng G, Guan L, Sun ZJ

Drug Design, Development and Therapy 2023, 17:1495-1502

Published Date: 18 May 2023

Original Research

Genetic Diversity and Characteristics of Drug Resistance Among Treatment-Naive People Living with HIV in Xi’an, China

Xia H, Jin J, Ba H, Zhang Y, Li J, Guo R, Li Y, Ma P, Zhang Y

Drug Design, Development and Therapy 2023, 17:1485-1494

Published Date: 17 May 2023

Review

Dexmedetomidine as an Adjuvant in Peripheral Nerve Block

Chen Z, Liu Z, Feng C, Jin Y, Zhao X

Drug Design, Development and Therapy 2023, 17:1463-1484

Published Date: 17 May 2023

Original Research

Therapeutic Efficacy of Boric Acid Treatment on Brain Tissue and Cognitive Functions in Rats with Experimental Alzheimer’s Disease

Özdemir Ç, Arslan M, Küçük A, Yığman Z, Dursun AD

Drug Design, Development and Therapy 2023, 17:1453-1462

Published Date: 17 May 2023

Original Research

Nano-Emulsion Based Gel for Topical Delivery of an Anti-Inflammatory Drug: In vitro and in vivo Evaluation

Gaber DA, Alsubaiyel AM, Alabdulrahim AK, Alharbi HZ, Aldubaikhy RM, Alharbi RS, Albishr WK, Mohamed HA

Drug Design, Development and Therapy 2023, 17:1435-1451

Published Date: 15 May 2023

Letter

Thoughtful Discussion on Article “Antimicrobial Peptide Cec4 Eradicates Multidrug-Resistant Acinetobacter baumannii in vitro and in vivo” [Letter]

Hidayat S, Isnawati R, Panjaitan NSD

Drug Design, Development and Therapy 2023, 17:1433-1434

Published Date: 15 May 2023

Original Research

Cinchonine, a Potential Oral Small-Molecule Glucagon-Like Peptide-1 Receptor Agonist, Lowers Blood Glucose and Ameliorates Non-Alcoholic Steatohepatitis

Xue H, Xing HJ, Wang B, Fu C, Zhang YS, Qiao X, Guo C, Zhang XL, Hu B, Zhao X, Deng LJ, Zhu XC, Zhang Y, Liu YF

Drug Design, Development and Therapy 2023, 17:1417-1432

Published Date: 11 May 2023

Original Research

Nalbuphine May Be Superior to Sufentanil in Relieving Postcesarean Uterine Contraction Pain in Multiparas: A Retrospective Cohort Study

Zheng K, Chen B, Sun J

Drug Design, Development and Therapy 2023, 17:1405-1415

Published Date: 8 May 2023

Original Research

Prolonged Anesthesia Induction to Delivery Time Did Not Influence Plasma Remifentanil Concentration in Neonates

Cai M, Liu H, Peng Y, Miao JK, Lei XF, Yu J

Drug Design, Development and Therapy 2023, 17:1395-1403

Published Date: 8 May 2023

Original Research

Identification of Piperlongumine as Potent Inhibitor of Necroptosis

He X, Li M, Ye Z, You X, Wang J, Xiao X, Zhu G, Wei J, Zha Y

Drug Design, Development and Therapy 2023, 17:1387-1394

Published Date: 8 May 2023

Original Research

16S rRNA and Metagenomics Combined with UPLC-Q/TOF-MS Metabolomics Analysis Reveals the Potential Mechanism of Radix Astragali Against Hyperuricemia in Mice

Deng S, Cai K, Pei C, Zhang X, Xiao X, Chen Y, Chen Y, Liang R, Chen Y, Li P, Xie Z, Liao Q

Drug Design, Development and Therapy 2023, 17:1371-1386

Published Date: 6 May 2023

Original Research

UBE2T Promotes Temozolomide Resistance of Glioblastoma Through Regulating the Wnt/β-Catenin Signaling Pathway

Wang Y, Gao G, Wei X, Zhang Y, Yu J

Drug Design, Development and Therapy 2023, 17:1357-1369

Published Date: 5 May 2023

Clinical Trial Report

Efficacy and Safety of a Subanesthetic Dose of Esketamine Combined with Propofol in Patients with Obesity Undergoing Painless Gastroscopy: A Prospective, Double-Blind, Randomized Controlled Trial

Zheng L, Wang Y, Ma Q, Liang W, Zhang X, Ren Z, Qin W, Meng F, Li Y, Fan G, Yin N

Drug Design, Development and Therapy 2023, 17:1347-1356

Published Date: 4 May 2023

Review

A Systematic Review of Systematic Reviews on the Use of Aromatase Inhibitors for the Treatment of Endometriosis: The Evidence to Date

Peitsidis P, Tsikouras P, Laganà AS, Laios A, Gkegkes ID, Iavazzo C

Drug Design, Development and Therapy 2023, 17:1329-1346

Published Date: 4 May 2023

Review

The Application of Dupilumab to Pediatric Patients Aged 6–11yrs with Moderate-to-Severe Atopic Dermatitis Whose Disease is Not Adequately Controlled: The Clinical Data so Far

Balboul S, Kahn J, Tracy A, Peacock A, Cline A

Drug Design, Development and Therapy 2023, 17:1323-1327

Published Date: 1 May 2023

Original Research

Feasibility and Safety of Remazolam versus Propofol When Inserting Laryngeal Masks Without Muscle Relaxants During Hysteroscopy

Tang S, Lu J, Xu C, Wei L, Mei S, Chen R, Meng QT

Drug Design, Development and Therapy 2023, 17:1313-1322

Published Date: 1 May 2023

Review

Clinical Utility of Osilodrostat in Cushing’s Disease: Review of Currently Available Literature

Perosevic M, Tritos NA

Drug Design, Development and Therapy 2023, 17:1303-1312

Published Date: 27 April 2023

Original Research

Integrating Network Pharmacology and Experimental Validation to Explore the Pharmacological Mechanism of Astragaloside IV in Treating Bleomycin-Induced Pulmonary Fibrosis

Yuan S, Zuo B, Zhou SC, Wang M, Tan KY, Chen ZW, Cao WF

Drug Design, Development and Therapy 2023, 17:1289-1302

Published Date: 27 April 2023

Original Research

AS-605240 Blunts Osteoporosis by Inhibition of Bone Resorption

Sun J, Cai G, Shen J, Cheng P, Zhang J, Jiang D, Xu X, Lu F, Chen L, Chen H

Drug Design, Development and Therapy 2023, 17:1275-1288

Published Date: 27 April 2023

Original Research

Synthesis of Amino Acids Bearing Halodifluoromethyl Moieties and Their Application to p53-Derived Peptides Binding to Mdm2/Mdm4

Vaas S, Zimmermann MO, Klett T, Boeckler FM

Drug Design, Development and Therapy 2023, 17:1247-1274

Published Date: 25 April 2023

Letter

Thinkful of Icariin Induces Triple-Negative Breast Cancer Cell Apoptosis and Suppresses Invasion by Inhibiting the JNK/c-Jun Signaling Pathway [Letter]

Mariya SS, Rinendyaputri R, Nikmah UA

Drug Design, Development and Therapy 2023, 17:1245-1246

Published Date: 24 April 2023

Clinical Trial Report

Cardiopulmonary Adverse Events of Remimazolam versus Propofol During Cervical Conization: A Randomized Controlled Trial

Wang L, Wang Y, Ma L, Wang Y, Mu X, Huang Z, Zheng Z, Nie H

Drug Design, Development and Therapy 2023, 17:1233-1243

Published Date: 22 April 2023

Original Research

Development of Verapamil Hydrochloride-loaded Biopolymer-based Composite Electrospun Nanofibrous Mats: In vivo Evaluation of Enhanced Burn Wound Healing without Scar Formation

Barakat HS, Freag MS, Gaber SM, Al Oufy A, Abdallah OY

Drug Design, Development and Therapy 2023, 17:1211-1231

Published Date: 21 April 2023

Clinical Trial Report

A Comparison of the Pharmacokinetics and Safety of Dapagliflozin Formate, an Ester Prodrug of Dapagliflozin, to Dapagliflozin Propanediol Monohydrate in Healthy Subjects

Kim HC, Lee S, Sung S, Kim E, Jang IJ, Chung JY

Drug Design, Development and Therapy 2023, 17:1203-1210

Published Date: 21 April 2023

Original Research

Virtual Screening and Biological Evaluation of Novel Low Molecular Weight Protein Tyrosine Phosphatase Inhibitor for the Treatment of Insulin Resistance

Feng B, Dong X, Liu Z, Zhang J, Liu H, Xu Y

Drug Design, Development and Therapy 2023, 17:1191-1201

Published Date: 21 April 2023

Original Research

Up-Regulation of miR-9-5p Inhibits Hypoxia-Ischemia Brain Damage Through the DDIT4-Mediated Autophagy Pathways in Neonatal Mice

Gai C, Xing X, Song Y, Zhao Y, Jiang Z, Cheng Y, Xiao Y, Wang Z

Drug Design, Development and Therapy 2023, 17:1175-1189

Published Date: 21 April 2023

Review

Knowledge Mapping of Drug Repositioning’s Theme and Development

Lang X, Liu J, Zhang G, Feng X, Dan W

Drug Design, Development and Therapy 2023, 17:1157-1174

Published Date: 18 April 2023

Response to Letter

Effects of the Different Doses of Esketamine on Postoperative Quality of Recovery in Patients Undergoing Modified Radical Mastectomy: A Randomized, Double-Blind, Controlled Trial [Response to Letter]

Zhu M, Xu S, Ju X, Wang S, Yu X

Drug Design, Development and Therapy 2023, 17:1155-1156

Published Date: 18 April 2023

Retraction

Umbelliferone Inhibits Spermatogenic Defects and Testicular Injury in Lead-Intoxicated Rats by Suppressing Oxidative Stress and Inflammation, and Improving Nrf2/HO-1 Signaling [Retraction]

Alotaibi MF, Al-Joufi F, Abou Seif HS, Alzoghaibi MA, Djouhri L, Ahmeda AF, Mahmoud AM

Drug Design, Development and Therapy 2023, 17:1153-1154

Published Date: 13 April 2023

Original Research

Berberine Alleviates Acute Lung Injury in Septic Mice by Modulating Treg/Th17 Homeostasis and Downregulating NF-κB Signaling

Chen L, Liu X, Wang X, Lu Z, Ye Y

Drug Design, Development and Therapy 2023, 17:1139-1151

Published Date: 13 April 2023

Original Research

Resveratrol Improves Paclitaxel-Induced Cognitive Impairment in Mice by Activating SIRT1/PGC-1α Pathway to Regulate Neuronal State and Microglia Cell Polarization

Liu X, Tang M, He TY, Zhao S, Li HZ, Li Z, Guo YX, Wang XL

Drug Design, Development and Therapy 2023, 17:1125-1138

Published Date: 12 April 2023

Original Research

Pharmacokinetics and Pharmacodynamics of Esomezol DR, a New Dual Delayed-Release Formulation of Esomeprazole 20 Mg or 40 Mg, in Healthy Subjects

Kim HC, Yang E, Ban MS, Kim YK, Hong SH, Jung J, Jang IJ, Lee S

Drug Design, Development and Therapy 2023, 17:1115-1124

Published Date: 12 April 2023

Original Research

Pharmacokinetic Interactions Between Bazedoxifene and Cholecalciferol: An Open-Label, Randomized, Crossover Study in Healthy Male Volunteers

Lee MH, Yoon SK, Kim H, Cho YS, Han S, Lee SH, Bae KS, Jung J, Hong SH, Lim HS

Drug Design, Development and Therapy 2023, 17:1107-1114

Published Date: 12 April 2023

Review

Review of Mavacamten for Obstructive Hypertrophic Cardiomyopathy and Future Directions

Dong T, Alencherry B, Ospina S, Desai MY

Drug Design, Development and Therapy 2023, 17:1097-1106

Published Date: 8 April 2023

Review

Celastrol: A Potential Natural Lead Molecule for New Drug Design, Development and Therapy for Memory Impairment

Amir Yusri MA, Sekar M, Wong LS, Gan SH, Ravi S, Subramaniyan V, Mat Rani NNI, Chidambaram K, Begum MY, Ramar M, Safi SZ, Selvaraj S, Wu YS, Revathy P, Fuloria S, Fuloria NK, Lum PT, Djearamane S

Drug Design, Development and Therapy 2023, 17:1079-1096

Published Date: 8 April 2023

Review

Chemistry, Biosynthesis and Pharmacology of Streptonigrin: An Old Molecule with Future Prospects for New Drug Design, Development and Therapy

Nabihah Nasir N, Sekar M, Ravi S, Wong LS, Sisinthy SP, Gan SH, Subramaniyan V, Chidambaram K, Mat Rani NNI, Begum MY, Ramar M, Safi SZ, Selvaraj S, Chinna Maruthu SK, Fuloria S, Fuloria NK, Lum PT, Djearamane S

Drug Design, Development and Therapy 2023, 17:1065-1078

Published Date: 8 April 2023

Retraction

TMF Inhibits miR-29a/Wnt/β-Catenin Signaling Through Upregulating Foxo3a Activity in Osteoarthritis Chondrocytes [Retraction]

Huang X, Chen Z, Shi W, Zhang R, Li L, Liu H, Wu L

Drug Design, Development and Therapy 2023, 17:1063-1064

Published Date: 7 April 2023

Original Research

Effectiveness and Safety of a Fixed-Dose Combination of Valsartan and Rosuvastatin (Rovatitan® Tablet) in Patients with Concomitant Hypertension and Hyperlipidemia: An Observational Study

Lee KJ, Ryu JK, Cho YH, Shin WY, Kim JS, Yoon YW, Jang JY, Kim WH, Beom JW, Kang SM

Drug Design, Development and Therapy 2023, 17:1047-1062

Published Date: 6 April 2023

Original Research

Antitumor Effects of Hydromorphone on Human Gastric Cancer Cells in vitro

Liang B, Li C, Zhou Z, Xie Y

Drug Design, Development and Therapy 2023, 17:1037-1045

Published Date: 6 April 2023

Clinical Trial Report

Effects of Combined Use of Salbutamol/Budesonide in Thoracic Surgery on Postoperative Myocardial Injury (MINS) – A Prospective Randomized Clinical Trial

Lin S, Zhang Y, Huang X, Zhang X, Cheng E, Zhou Z, Liu J

Drug Design, Development and Therapy 2023, 17:1025-1036

Published Date: 1 April 2023

Original Research

Therapeutic Mechanism of Baicalin in Experimental Colitis Analyzed Using Network Pharmacology and Metabolomics

Wu Q, Wu X, Wang M, Liu K, Li Y, Ruan X, Qian L, Meng L, Sun Z, Zhu L, Wu J, Mu G

Drug Design, Development and Therapy 2023, 17:1007-1024

Published Date: 31 March 2023

Original Research

5-Fluorouracil Combined with Rutaecarpine Synergistically Suppresses the Growth of Colon Cancer Cells by Inhibiting STAT3

Yu Z, Chan S, Wang X, Sun R, Wang M, Wang Z, Zuo X, Chen J, Zhang H, Chen W

Drug Design, Development and Therapy 2023, 17:993-1006

Published Date: 30 March 2023

Original Research

Antimicrobial Peptide Cec4 Eradicates Multidrug-Resistant Acinetobacter baumannii in vitro and in vivo

Peng J, Wang Y, Wu Z, Mao C, Li L, Cao H, Qiu Z, Guo G, Liang G, Shen F

Drug Design, Development and Therapy 2023, 17:977-992

Published Date: 30 March 2023

Review

Intravitreal Fluocinolone Acetonide Implant (ILUVIEN®) for the Treatment of Retinal Conditions. A Review of Clinical Studies

Mushtaq Y, Mushtaq MM, Gatzioufas Z, Ripa M, Motta L, Panos GD

Drug Design, Development and Therapy 2023, 17:961-975

Published Date: 30 March 2023

Retraction

Orcinol Glucoside Facilitates the Shift of MSC Fate to Osteoblast and Prevents Adipogenesis via Wnt/β-Catenin Signaling Pathway [Retraction]

Zhou X, Liu Z, Huang B, Yan H, Yang C, Li Q, Jin D

Drug Design, Development and Therapy 2023, 17:959-960

Published Date: 28 March 2023

Original Research

Investigating the Mechanism of Action of Schisandra chinensis Combined with Coenzyme Q10 in the Treatment of Heart Failure Based on PI3K-AKT Pathway

Wen S, Yang K, Bai Y, Wu Y, Liu D, Wu X, Zhang X, Sun J

Drug Design, Development and Therapy 2023, 17:939-957

Published Date: 27 March 2023

Letter

Effects of the Different Doses of Esketamine on Postoperative Quality of Recovery in Patients Undergoing Modified Radical Mastectomy: A Randomized, Double-Blind, Controlled Trial [Letter]

Cheng Y, Xue FS, Li CW

Drug Design, Development and Therapy 2023, 17:937-938

Published Date: 27 March 2023

Original Research

Synthesis and Biological Evaluation of Gentiopicroside Derivatives as Novel Cyclooxygenase-2 Inhibitors with Anti-Inflammatory Activity

Ren G, Zhang Q, Xia P, Wang J, Fang P, Jin X, Peng X, Xu Y, Zhang J, Zhao L

Drug Design, Development and Therapy 2023, 17:919-935

Published Date: 23 March 2023

Original Research

Network Pharmacology and Experimental Validation to Explore the Effect and Mechanism of Kanglaite Injection Against Triple-Negative Breast Cancer

Zhao M, Fu L, Xu P, Wang T, Li P

Drug Design, Development and Therapy 2023, 17:901-917

Published Date: 23 March 2023

Original Research

Network Pharmacology and Experimental Validation to Explore That Celastrol Targeting PTEN is the Potential Mechanism of Tripterygium wilfordii (Lév.) Hutch Against IgA Nephropathy

Zhao J, Liu H, Xia M, Chen Q, Wan L, Leng B, Tang C, Chen G, Liu Y, Zhang L, Liu H

Drug Design, Development and Therapy 2023, 17:887-900

Published Date: 23 March 2023

Review

Oliceridine for the Management of Moderate to Severe Acute Postoperative Pain: A Narrative Review

Daksla N, Wang A, Jin Z, Gupta A, Bergese SD

Drug Design, Development and Therapy 2023, 17:875-886

Published Date: 22 March 2023

Original Research

Effect of Subanesthetic Dose of Esketamine on Perioperative Neurocognitive Disorders in Elderly Undergoing Gastrointestinal Surgery: A Randomized Controlled Trial

Han C, Ji H, Guo Y, Fei Y, Wang C, Yuan Y, Ruan Z, Ma T

Drug Design, Development and Therapy 2023, 17:863-873

Published Date: 21 March 2023

Review

Tapentadol: A Review of Experimental Pharmacology Studies, Clinical Trials, and Recent Findings

Alshehri FS

Drug Design, Development and Therapy 2023, 17:851-861

Published Date: 21 March 2023

Original Research

Effect of Different Doses of Butorphanol on Postoperative Shivering in Elderly Patients: A Randomized, Double-Blind, Placebo-Controlled Trial

Wang Y, Zhao K, Wu N, Ji T, Su G, Cui X, Dong Y, Chen X

Drug Design, Development and Therapy 2023, 17:839-849

Published Date: 20 March 2023

Letter

Critical Response to Article “Integrated Network Pharmacology and Experimental Validation Approach to Investigate the Mechanisms of Stigmasterol in the Treatment of Rheumatoid Arthritis” [Letter]

Rinendyaputri R, Panjaitan NSD

Drug Design, Development and Therapy 2023, 17:837-838

Published Date: 20 March 2023

Original Research

Icariin Induces Triple-Negative Breast Cancer Cell Apoptosis and Suppresses Invasion by Inhibiting the JNK/c-Jun Signaling Pathway

Gao S, Zhang X, Liu J, Ji F, Zhang Z, Meng Q, Zhang Q, Han X, Wu H, Yin Y, Lv Y, Shi W

Drug Design, Development and Therapy 2023, 17:821-836

Published Date: 20 March 2023

Original Research

Personalized Dose of Adjuvant Imatinib in Patients with Gastrointestinal Stromal Tumors: Results from a Population Pharmacokinetic Analysis

Jiang X, Fu Q, Jing Y, Kong Y, Liu H, Peng H, Rexiti K, Wei X

Drug Design, Development and Therapy 2023, 17:809-820

Published Date: 14 March 2023

Retraction

Evaluation of Natural Bioactive-Derived Punicalagin Niosomes in Skin-Aging Processes Accelerated by Oxidant and Ultraviolet Radiation [Retraction]

Mohamad EA, Aly AA, Khalaf AA, Ahmed MI, Kamel RM, Abdelnaby SM, Abdelzaher YH, Sedrak MG, Mousa SA

Drug Design, Development and Therapy 2023, 17:807-808

Published Date: 13 March 2023

Original Research

Glucagon-Like Peptide-1 Receptor Agonist Protects Against Diabetic Cardiomyopathy by Modulating microRNA-29b-3p/SLMAP

Fang P, Ye Z, Li R, She D, Zong G, Zhang L, Xue Y, Zhang K

Drug Design, Development and Therapy 2023, 17:791-806

Published Date: 12 March 2023

Review

The Molecular Basis of the Anti-Inflammatory Property of Astragaloside IV for the Treatment of Diabetes and Its Complications

Li L, Zhang Y, Luo Y, Meng X, Pan G, Zhang H, Li Y, Zhang B

Drug Design, Development and Therapy 2023, 17:771-790

Published Date: 10 March 2023

Original Research

Effect of Food on the Pharmacokinetics and Safety of a Novel c-Met Inhibitor SCC244: A Randomized Phase I Study in Healthy Subjects

Wu J, Xu H, Li H, Ma L, Chen J, Yuan F, Sheng L, Liu C, Chen W, Li X

Drug Design, Development and Therapy 2023, 17:761-769

Published Date: 10 March 2023

Original Research

Computational Systems Pharmacology and Molecular Docking Reveal an Anti-Apoptosis and Anti-Inflammatory Mechanism of Compound Angelica Ligusticum Wallichii Granules in the Treatment of Endometriosis

Li Y, Zhu J, Tang J

Drug Design, Development and Therapy 2023, 17:743-759

Published Date: 9 March 2023

Review

Kimyrsa and Orbactiv – A Tale of Two Formulations

Jackson BT, Cluck DB, Henao-Martínez AF, Chastain DB

Drug Design, Development and Therapy 2023, 17:737-742

Published Date: 9 March 2023

Original Research

Integrating Network Pharmacology, Molecular Docking and Pharmacological Evaluation for Exploring the Polyrhachis vicina Rogers in Ameliorating Depression

He J, Han D, Jia C, Xie J, Zhu F, Wei J, Li D, Wei D, Li Y, Tang L, Wei G, Yan J, Tong Y, Yang L, Tan X

Drug Design, Development and Therapy 2023, 17:717-735

Published Date: 9 March 2023

Original Research

Inhalational Anesthesia is Noninferior to Total Intravenous Anesthesia in Terms of Surgical Field Visibility in Endoscopic Sinus Surgery: A Randomized, Double-Blind Study

Li H, Du Y, Yang W, Wang Y, Su S, Zhao X, Wang G

Drug Design, Development and Therapy 2023, 17:707-716

Published Date: 9 March 2023

Original Research

Integrated Network Pharmacology and Experimental Validation Approach to Investigate the Mechanisms of Stigmasterol in the Treatment of Rheumatoid Arthritis

Xie W, Yang H, Guo C, Xie R, Yu G, Li Y

Drug Design, Development and Therapy 2023, 17:691-706

Published Date: 7 March 2023

Original Research

Wuling San Based on Network Pharmacology and in vivo Evidence Against Hyperuricemia via Improving Oxidative Stress and Inhibiting Inflammation

Huang J, Lin Z, Wang Y, Ding X, Zhang B

Drug Design, Development and Therapy 2023, 17:675-690

Published Date: 4 March 2023

Original Research

Integrating Network Pharmacology and Bioinformatics to Explore the Effects of Dangshen (Codonopsis pilosula) Against Hepatocellular Carcinoma: Validation Based on the Active Compound Luteolin

Yu Y, Ding S, Xu X, Yan D, Fan Y, Ruan B, Zhang X, Zheng L, Jie W, Zheng S

Drug Design, Development and Therapy 2023, 17:659-673

Published Date: 1 March 2023

Original Research

New IMB16-4 Hot-Melt Extrusion Preparation Improved Oral Bioavailability and Enhanced Anti-Cholestatic Effect on Rats

Li Y, Tian C, Song X, Du M, Zhang G, Liu H

Drug Design, Development and Therapy 2023, 17:649-657

Published Date: 28 February 2023

Retraction

Therapeutic Effects of Tyroserleutide on Lung Metastasis of Human Hepatocellular Carcinoma SK-HEP-1 and Its Mechanism Affecting ICAM-1 and MMP-2 and -9 [Retraction]

Che X, Lu R, Fu Z, Sun Y, Zhu Z, Li J, Wang S, Jia J, Wang Q, Yao Z

Drug Design, Development and Therapy 2023, 17:647-648

Published Date: 28 February 2023

Original Research

Chondroprotective Mechanism of Eucommia ulmoides Oliv.-Glycyrrhiza uralensis Fisch. Couplet Medicines in Knee Osteoarthritis via Experimental Study and Network Pharmacology Analysis

Wang P, Xu J, Sun Q, Ge Q, Qiu M, Zou K, Ying J, Yuan W, Chen J, Zeng Q, Cui Q, Jin H, Zhang C, Li F

Drug Design, Development and Therapy 2023, 17:633-646

Published Date: 27 February 2023

Original Research

Mechanistic Study of Schisandra chinensis Fruit Mixture Based on Network Pharmacology, Molecular Docking and Experimental Validation to Improve the Inflammatory Response of DKD Through AGEs/RAGE Signaling Pathway

Li H, Dong A, Li N, Ma Y, Zhang S, Deng Y, Chen S, Zhang M

Drug Design, Development and Therapy 2023, 17:613-632

Published Date: 27 February 2023

Original Research

Effects and Potential Mechanism of Zhuyu Pill Against Atherosclerosis: Network Pharmacology and Experimental Validation

Pan Y, Feng X, Song W, Zhou X, Zhou Z, Chen G, Shen T, Zhang X

Drug Design, Development and Therapy 2023, 17:597-612

Published Date: 23 February 2023

Original Research

Efficacy and Mechanism of Qianshan Huoxue Gao in Acute Coronary Syndrome via Regulation of Intestinal Flora and Metabolites

Zhao N, Ma Y, Liang X, Zhang Y, Hong D, Wang Y, Bai D

Drug Design, Development and Therapy 2023, 17:579-595

Published Date: 22 February 2023

Original Research

α-Mangostin Inhibited M1 Polarization of Macrophages/Monocytes in Antigen-Induced Arthritis Mice by Up-Regulating Silent Information Regulator 1 and Peroxisome Proliferators-Activated Receptor γ Simultaneously

Wu YJ, Zhang SS, Yin Q, Lei M, Wang QH, Chen WG, Luo TT, Zhou P, Ji CL

Drug Design, Development and Therapy 2023, 17:563-577

Published Date: 23 February 2023

Original Research

Assessment of Response to Different Induction Chemotherapy Regimens in Locally Advanced Nasopharyngeal Carcinoma

Lian CL, Zhou R, Zhou Y, Zhou P, Wu SG

Drug Design, Development and Therapy 2023, 17:551-562

Published Date: 22 February 2023

Original Research

Andrographolide Inhibits Static Mechanical Pressure-Induced Intervertebral Disc Degeneration via the MAPK/Nrf2/HO-1 Pathway

Zhang C, Lu Z, Lyu C, Zhang S, Wang D

Drug Design, Development and Therapy 2023, 17:535-550

Published Date: 20 February 2023

Original Research

Anti-Arthritic Effect of Edaravone Against Complete Freund Adjuvant Induced Arthritis via Osteoclast Differentiation and HIF-1α–VEGF–ANG-1 Axis

Liu J, Zhao N, Su SH, Gao Y, Qi B

Drug Design, Development and Therapy 2023, 17:519-534

Published Date: 18 February 2023

Original Research

Efficacy and Prognostic Factors of Regorafenib in the Treatment of BCLC Stage C Hepatocellular Carcinoma After Failure of the First-Line Therapy

Xu B, Lu D, Liu K, Lv W, Xiao J, Zhang X, Zhang Z, Chai J, Wang L

Drug Design, Development and Therapy 2023, 17:507-518

Published Date: 16 February 2023

Original Research

Development of a Fast Onset Proton Pump Inhibitor: Comparison of Fixed-Dose Combination of Rabeprazole and Sodium Bicarbonate (YPI-011) to the Conventional Enteric-Coated Rabeprazole

Bae S, Kwon J, Lee MH, Yu KS, Lee S

Drug Design, Development and Therapy 2023, 17:497-506

Published Date: 15 February 2023

Original Research

The Therapeutic Mechanism of Schisandrol A and Its Metabolites on Pulmonary Fibrosis Based on Plasma Metabonomics and Network Analysis

Qiaolongbatu X, Zhao W, Huang X, Qian F, Yang X, Wu J, Ma C, Qu H, Wang L, Fan G, Wu Z

Drug Design, Development and Therapy 2023, 17:477-496

Published Date: 15 February 2023

Original Research

Exploring the Active Compounds of Traditional Mongolian Medicine Baolier Capsule (BLEC) in Patients with Coronary Artery Disease (CAD) Based on Network Pharmacology Analysis, Molecular Docking and Experimental Validation

Wei M, Li F, Guo K, Yang T

Drug Design, Development and Therapy 2023, 17:459-476

Published Date: 14 February 2023

Original Research

The Underling Mechanisms Exploration of Rubia cordifolia L. Extract Against Rheumatoid Arthritis by Integrating Network Pharmacology and Metabolomics

Zeng W, Fang Y, Mo S, Shen C, Yang H, Luo G, Xiao L, Zhan R, Yan P

Drug Design, Development and Therapy 2023, 17:439-457

Published Date: 11 February 2023

Original Research

Preparation of Cod Skin Collagen Peptides/Chitosan-Based Temperature-Sensitive Gel and Its Anti-Photoaging Effect in Skin

Kong S, Lv L, Guo J, Yang X, Liao M, Zhao T, Sun H, Zhang S, Li W

Drug Design, Development and Therapy 2023, 17:419-437

Published Date: 10 February 2023

Original Research

Dual Sensitization Anti-Resistant Nanoparticles for Treating Refractory Breast Cancers via Apoptosis-Inducing

Ju R, Wu F, Tian Y, Chu J, Peng X, Wang X

Drug Design, Development and Therapy 2023, 17:403-418

Published Date: 10 February 2023

Original Research

Solanine Represses Gastric Cancer Growth by Mediating Autophagy Through AAMDC/MYC/ATF4/Sesn2 Signaling Pathway

Tang X, Guo Y, Zhang S, Wang X, Teng Y, Jin Q, Jin Q, Shen W, Wang R

Drug Design, Development and Therapy 2023, 17:389-402

Published Date: 8 February 2023

Original Research

Comparison of Remimazolam Tosilate and Etomidate on Hemodynamics in Cardiac Surgery: A Randomised Controlled Trial

Hu B, Zhang M, Wu Z, Zhang X, Zou X, Tan L, Song T, Li X

Drug Design, Development and Therapy 2023, 17:381-388

Published Date: 8 February 2023

Review

Profile of Linzagolix in the Management of Endometriosis, Including Design, Development and Potential Place in Therapy: A Narrative Review

Donnez J, Cacciottola L, Squifflet JL, Dolmans MM

Drug Design, Development and Therapy 2023, 17:369-380

Published Date: 8 February 2023

Review

Ibrexafungerp for the Treatment of Vulvovaginal Candidiasis: Design, Development and Place in Therapy

Phillips NA, Rocktashel M, Merjanian L

Drug Design, Development and Therapy 2023, 17:363-367

Published Date: 7 February 2023

Review

Bibliometric Study of Adaptogens in Dermatology: Pharmacophylogeny, Phytochemistry, and Pharmacological Mechanisms

Liu XX, Chen CY, Li L, Guo MM, He YF, Meng H, Dong YM, Xiao PG, Yi F

Drug Design, Development and Therapy 2023, 17:341-361

Published Date: 6 February 2023

Review

Tebentafusp in the Treatment of Metastatic Uveal Melanoma: Patient Selection and Special Considerations

Montazeri K, Pattanayak V, Sullivan RJ

Drug Design, Development and Therapy 2023, 17:333-339

Published Date: 7 February 2023

Letter

Liquiritin Protects Against Cardiac Fibrosis After Myocardial Fibrosis After Myocardial Infarction by Inhibiting CCL5 Expression and the NF-κB Signaling Pathway [Letter]

Idrus HH, Sunarno

Drug Design, Development and Therapy 2023, 17:331-332

Published Date: 5 February 2023

Original Research

Shensong Yangxin Capsule Reduces the Susceptibility of Arrhythmia in db/db Mice via Inhibiting the Inflammatory Response Induced by Endothelium Dysfunction

Zhang J, Li H, Wang D, Gu J, Hou Y, Wu Y

Drug Design, Development and Therapy 2023, 17:313-330

Published Date: 5 February 2023

Original Research

Sichen Formula Ameliorates Lipopolysaccharide-Induced Acute Lung Injury via Blocking the TLR4 Signaling Pathways

Yan LS, Cui S, Cheng BCY, Yin XB, Wang YW, Qiu XY, Nima CR, Zhang Y, Zhang SF

Drug Design, Development and Therapy 2023, 17:297-312

Published Date: 2 February 2023

Original Research

Vancomycin Induced Ferroptosis in Renal Injury Through the Inactivation of Recombinant Glutathione Peroxidase 4 and the Accumulation of Peroxides

Yin X, Yang Q, Li H, Kang Y, Li Z

Drug Design, Development and Therapy 2023, 17:283-295

Published Date: 1 February 2023

Review

Clinical Evaluation of Risankizumab in the Treatment of Adults with Moderately to Severely Active Crohn’s Disease: Patient Selection and Reported Outcomes

Horst S, Cross RK

Drug Design, Development and Therapy 2023, 17:273-282

Published Date: 31 January 2023

Original Research

Development and Evaluation of Self-Emulsifying Drug-Delivery System–Based Tablets for Simvastatin, a BCS Class II Drug

Bashir MA, Khan A, Shah SI, Ullah M, Khuda F, Abbas M, Goh KW, Ming LC

Drug Design, Development and Therapy 2023, 17:261-272

Published Date: 26 January 2023

Original Research

An Integrative Pharmacology-Based Strategy to Uncover the Mechanism of Zuogui Jiangtang Shuxin Formula in Diabetic Cardiomyopathy

Huang Y, Zhang Y, Wu Y, Xiang Q, Yu R

Drug Design, Development and Therapy 2023, 17:237-260

Published Date: 26 January 2023

Original Research

Menthone Exerts its Antimicrobial Activity Against Methicillin Resistant Staphylococcus aureus by Affecting Cell Membrane Properties and Lipid Profile

Zhao W, Yang C, Zhang N, Peng Y, Ma Y, Gu K, Liu X, Liu X, Liu X, Liu Y, Li S, Zhao L

Drug Design, Development and Therapy 2023, 17:219-236

Published Date: 25 January 2023

Original Research

Safety, Tolerability, and Pharmacokinetics of Benralizumab: A Phase 1, Randomized, Single-Blind Study of Healthy Chinese Participants

Cheung TT, Mai TH, Chia YL, Yap DYH, Lee CH, Chen CC, Huang Y, Jin Y, Johnston J, Werkström V, Yao Y, Ge X, Zheng W

Drug Design, Development and Therapy 2023, 17:209-218

Published Date: 26 January 2023

Original Research

Mucoadhesive Nanoparticles Enhance the Therapeutic Effect of Dexamethasone on Experimental Ulcerative Colitis by the Local Administration as an Enema

Dong K, Deng SJ, He BY, Guo ZY, Guan ZL, Leng X, Ma RR, Wang DY, Xing JF, You CY

Drug Design, Development and Therapy 2023, 17:191-207

Published Date: 24 January 2023

Review

Research Progress on the Efficacy and Safety of Spironolactone in Reversing Left Ventricular Hypertrophy in Hemodialysis Patients

Sun Z, Chen Z, Liu R, Lu G, Li Z, Sun Y

Drug Design, Development and Therapy 2023, 17:181-190

Published Date: 23 January 2023

Original Research

Evaluation of Chitosan-Oleuropein Nanoparticles on the Durability of Dentin Bonding

Zhao S, Zhang Y, Chen Y, Xing X, Wang Y, Wu G

Drug Design, Development and Therapy 2023, 17:167-180

Published Date: 22 January 2023

Review

Bulevirtide in the Treatment of Hepatitis Delta: Drug Discovery, Clinical Development and Place in Therapy

Soriano V, Moreno-Torres V, Treviño A, Corral O, de Mendoza C

Drug Design, Development and Therapy 2023, 17:155-166

Published Date: 21 January 2023

Clinical Trial Report

Effect of Remimazolam on Postoperative Delirium in Older Adult Patients Undergoing Orthopedic Surgery: A Prospective Randomized Controlled Clinical Trial

Yang JJ, Lei L, Qiu D, Chen S, Xing LK, Zhao JW, Mao YY, Yang JJ

Drug Design, Development and Therapy 2023, 17:143-153

Published Date: 20 January 2023

Original Research

10-Gingerol Enhances the Effect of Taxol in Triple-Negative Breast Cancer via Targeting ADRB2 Signaling

Liang Y, Wu G, Luo T, Xie H, Zuo Q, Huang P, Li H, Chen L, Lu H, Chen Q

Drug Design, Development and Therapy 2023, 17:129-142

Published Date: 20 January 2023

Original Research

A Novel Approach Based on Gut Microbiota Analysis and Network Pharmacology to Explain the Mechanisms of Action of Cichorium intybus L. Formula in the Improvement of Hyperuricemic Nephropathy in Rats

Amatjan M, Li N, He P, Zhang B, Mai X, Jiang Q, Xie H, Shao X

Drug Design, Development and Therapy 2023, 17:107-128

Published Date: 20 January 2023

Original Research

Identification of a Class of WNK Isoform-Specific Inhibitors Through High-Throughput Screening

Chlebowicz J, Akella R, Humphreys JM, He H, Kannangara AR, Wei S, Posner B, Goldsmith EJ

Drug Design, Development and Therapy 2023, 17:93-105

Published Date: 20 January 2023

Original Research

The Benefits of Molnupiravir Treatment in Healthcare Facilities Patients with COVID-19

Cheng SL, Wang PH, Chang CY, Wang HH, Wang CJ, Chiu KM

Drug Design, Development and Therapy 2023, 17:87-92

Published Date: 19 January 2023

Original Research

A Pharmacodynamic Evaluation of the Protective Effects of Roxadustat Against Hypoxic Injury at High Altitude

Guo Q, Li X, Li W, Wang R, Zhao A, Wang Z

Drug Design, Development and Therapy 2023, 17:75-85

Published Date: 15 January 2023

Original Research

Pharmacological Mechanism of Sancao Yuyang Decoction in the Treatment of Oral Mucositis Based on Network Pharmacology and Experimental Validation

Liu Y, Ye Y, Xie G, Xu Y, Cheng M, Li C, Qu M, Zhu F

Drug Design, Development and Therapy 2023, 17:55-74

Published Date: 13 January 2023

Original Research

Network Pharmacology and Experimental Validation to Explore the Molecular Mechanisms of Compound Huangbai Liquid for the Treatment of Acne

Di H, Liu H, Xu S, Yi N, Wei G

Drug Design, Development and Therapy 2023, 17:39-53

Published Date: 11 January 2023

Review

Review on the Diverse Biological Effects of Glabridin

Zhang J, Wu X, Zhong B, Liao Q, Wang X, Xie Y, He X

Drug Design, Development and Therapy 2023, 17:15-37

Published Date: 10 January 2023

Original Research

Binary Nanodrug-Delivery System Designed for Leukemia Therapy: Aptamer- and Transferrin-Codecorated Daunorubicin- and Luteolin-Coloaded Nanoparticles

Zhu Y, Zhang W, Chen J

Drug Design, Development and Therapy 2023, 17:1-13

Published Date: 6 January 2023