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Drug Design, Development and Therapy
ISSN: 1177-8881
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Archive: Volume 12, 2018
- default (382)
- A cross-sectional survey on heart failure from China: disease burden and management (3)
3-n-butylphthalide exerts neuroprotective effects by enhancing anti-oxidation and attenuating mitochondrial dysfunction in an in vitro model of ischemic stroke
Chen N, Zhou Z, Li J, Li B, Feng J, He D, Luo Y, Zheng X, Luo J, Zhang J
Drug Design, Development and Therapy 2018, 12:4261-4271
Published Date: 14 December 2018
MMI-0100 ameliorates lung inflammation in a mouse model of acute respiratory distress syndrome by reducing endothelial expression of ICAM-1
He B, Geng S, Zhou W, Rui Y, Mu X, Zhang C, You Q, Su X
Drug Design, Development and Therapy 2018, 12:4253-4260
Published Date: 13 December 2018
Gamma linolic acid regulates PHD2 mediated hypoxia and mitochondrial apoptosis in DEN induced Hepatocellular carcinoma
Cui H, Han F, Zhang L, Wang L, Kumar M
Drug Design, Development and Therapy 2018, 12:4241-4252
Published Date: 13 December 2018
Topical anesthesia therapy using lidocaine-loaded nanostructured lipid carriers: tocopheryl polyethylene glycol 1000 succinate-modified transdermal delivery system
Zhao X, Sun Y, Li Z
Drug Design, Development and Therapy 2018, 12:4231-4240
Published Date: 13 December 2018
Comparison of efficacy and safety between two different irbesartan, generic vs branded, in the treatment of Korean patients with mild-to-moderate hypertension: an 8-week, multicenter, randomized, open-label, Phase IV clinical study
Han SH, Oh GC, Kwon HM, Park CG, Kim IJ, Hwang GS, Yoo BS, Park SH, Lee KJ, Kim HS
Drug Design, Development and Therapy 2018, 12:4217-4229
Published Date: 19 December 2018
Iron oxide nanoparticles as nanocarriers to improve chlorin e6-based sonosensitivity in sonodynamic therapy
Zhang P, Ren Z, Chen Z, Zhu J, Liang J, Liao R, Wen J
Drug Design, Development and Therapy 2018, 12:4207-4216
Published Date: 10 December 2018
Recent development in the strategies projected for chikungunya vaccine in humans
Goyal M, Chauhan A, Goyal V, Jaiswal N, Singh S, Singh M
Drug Design, Development and Therapy 2018, 12:4195-4206
Published Date: 10 December 2018
Comment on the intravenous tranexamic acid use in revision total joint arthroplasty
He J, Liu Y
Drug Design, Development and Therapy 2018, 12:4191-4194
Published Date: 10 December 2018
ADAR1 silencing-induced HUVEC apoptosis is mediated by FGFR2 under hypoxia stress
Jiang Y, Wang Z, Chen X, Wang W, Wang X
Drug Design, Development and Therapy 2018, 12:4181-4189
Published Date: 10 December 2018
Best tigecycline dosing for treatment of infections caused by multidrug-resistant pathogens in critically ill patients with different body weights
Ibrahim MM, Abuelmatty AM, Mohamed GH, Nasr MA, Hussein AK, Ebaed MED, Sarhan HA
Drug Design, Development and Therapy 2018, 12:4171-4179
Published Date: 7 December 2018
SREBP-2, a new target of metformin?
Zhang F, Sun W, Chen J, Jiang L, Yang P, Huang Y, Gong A, Liu S, Ma S
Drug Design, Development and Therapy 2018, 12:4163-4170
Published Date: 6 December 2018
Quercetin inhibits transforming growth factor β1-induced epithelial–mesenchymal transition in human retinal pigment epithelial cells via the Smad pathway
Cai W, Yu D, Fan J, Liang X, Jin H, Liu C, Zhu M, Shen T, Zhang R, Hu W, Wei Q, Yu J
Drug Design, Development and Therapy 2018, 12:4149-4161
Published Date: 6 December 2018
Synthesis of small peptide compounds, molecular docking, and inhibitory activity evaluation against phosphatases PTP1B and SHP2
Kostrzewa T, Sahu KK, Gorska-Ponikowska M, Tuszynski JA, Kuban-Jankowska A
Drug Design, Development and Therapy 2018, 12:4139-4147
Published Date: 5 December 2018
The role of various transporters in the placental uptake of ofloxacin in an in vitro model of human villous trophoblasts
Polachek H, Debotton N, Feinshtein V, Rubin M, Ben-Zvi Z, Holcberg G, Agbaria R, Dahan A
Drug Design, Development and Therapy 2018, 12:4129-4138
Published Date: 4 December 2018
N-acetylcysteine amide provides neuroprotection via Nrf2-ARE pathway in a mouse model of traumatic brain injury
Zhou Y, Wang HD, Zhou XM, Fang J, Zhu L, Ding K
Drug Design, Development and Therapy 2018, 12:4117-4127
Published Date: 4 December 2018
Ferulic acid attenuates liver fibrosis and hepatic stellate cell activation via inhibition of TGF-β/Smad signaling pathway
Mu M, Zuo S, Wu RM, Deng KS, Lu S, Zhu JJ, Zou GL, Yang J, Cheng ML, Zhao XK
Drug Design, Development and Therapy 2018, 12:4107-4115
Published Date: 3 December 2018
Curcumin alleviates rheumatoid arthritis-induced inflammation and synovial hyperplasia by targeting mTOR pathway in rats
Dai QD, Zhou D, Xu LP, Song XW
Drug Design, Development and Therapy 2018, 12:4095-4105
Published Date: 3 December 2018
The synergistic effect of 2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-glucoside combined with Adriamycin on MCF-7 breast cancer cells
Shen JF, Zhang YZ, Shen H, Pan H, Xu LS, Yuan LN, Ding ZY
Drug Design, Development and Therapy 2018, 12:4083-4094
Published Date: 30 November 2018
Beraprost sodium preconditioning prevents inflammation, apoptosis, and autophagy during hepatic ischemia-reperfusion injury in mice via the P38 and JNK pathways
Deng J, Feng J, Liu T, Lu X, Wang W, Liu N, Lv Y, Liu Q, Guo C, Zhou Y
Drug Design, Development and Therapy 2018, 12:4067-4082
Published Date: 29 November 2018
Spotlight on inhaled ciprofloxacin and its potential in the treatment of non-cystic fibrosis bronchiectasis
Chorepsima S, Kechagias KS, Kalimeris G, Triarides NA, Falagas ME
Drug Design, Development and Therapy 2018, 12:4059-4066
Published Date: 27 November 2018
Pharmacokinetics of single- and multiple-dose roflumilast: an open-label, three-way crossover study in healthy Chinese volunteers
Huang J, Fu CX, Yang XY, Cui C, Yang S, Kuang Y, Guo CX, Hu P, Pei Q, Yang GP
Drug Design, Development and Therapy 2018, 12:4047-4057
Published Date: 26 November 2018
Schisandrin B elicits the Keap1-Nrf2 defense system via carbene reactive metabolite which is less harmful to mice liver
Feng S, Qiu B, Zou L, Liu K, Xu X, Zhu H
Drug Design, Development and Therapy 2018, 12:4033-4046
Published Date: 23 November 2018
Icariin promotes the migration of bone marrow stromal cells via the SDF-1α/HI F-1α/CXCR 4 pathway
Zhu H, Wang X, Han Y, Zhang W, Xin W, Zheng X, Zhang J
Drug Design, Development and Therapy 2018, 12:4023-4031
Published Date: 22 November 2018
Mechanism involved in insulin resistance via accumulation of β-amyloid and neurofibrillary tangles: link between type 2 diabetes and Alzheimer’s disease
Rad SK, Arya A, Karimian H, Madhavan P, Rizwan F, Koshy S, Prabhu G
Drug Design, Development and Therapy 2018, 12:3999-4021
Published Date: 22 November 2018
Schisandrin B protects against angiotensin II-induced endotheliocyte deficits by targeting Keap1 and activating Nrf2 pathway
Han J, Shi X, Zheng Z, Zhang B, Shi F, Jiang L, Xu J
Drug Design, Development and Therapy 2018, 12:3985-3997
Published Date: 22 November 2018
Inhibition of ROS-mediated activation Src-MAPK/AKT signaling by orientin alleviates H2O2-induced apoptosis in PC12 cells
Qi S, Feng Z, Li Q, Qi Z, Zhang Y
Drug Design, Development and Therapy 2018, 12:3973-3984
Published Date: 16 November 2018
Baicalein induces apoptosis and autophagy of breast cancer cells via inhibiting PI3K/AKT pathway in vivo and vitro
Yan W, Ma X, Zhao X, Zhang S
Drug Design, Development and Therapy 2018, 12:3961-3972
Published Date: 16 November 2018
Valproic acid enhances the viability of random pattern skin flaps: involvement of enhancing angiogenesis and inhibiting oxidative stress and apoptosis
Wu H, Ding J, Wang L, Lin J, Li S, Xiang G, Jiang L, Xu H, Gao W, Zhou K
Drug Design, Development and Therapy 2018, 12:3951-3960
Published Date: 16 November 2018
Gene transfer to rat cerebral cortex mediated by polysorbate 80 and poloxamer 188 nonionic surfactant vesicles
Attia N, Mashal M, Soto-Sánchez C, Martinez-Navarrete G., Fernández E, Grijalvo S, Eritja R, Puras G, Pedraz JL
Drug Design, Development and Therapy 2018, 12:3937-3949
Published Date: 16 November 2018
Effectiveness of thiazides on serum and urinary calcium levels and bone mineral density in patients with osteoporosis: a systematic review and meta-analysis
Cheng L, Zhang K, Zhang Z
Drug Design, Development and Therapy 2018, 12:3929-3935
Published Date: 14 November 2018
Arsenic sulfide amplifies JQ1 toxicity via mitochondrial pathway in gastric and colon cancer cells
Tan Z, Zhang X, Kang T, Zhang L, Chen S
Drug Design, Development and Therapy 2018, 12:3913-3927
Published Date: 14 November 2018
A study on screening and antitumor effect of CD55-specific ligand peptide in cervical cancer cells
Liu G, Yin Q, Ji H, Wang Y, Liu H, Jiang L, Zhu F, Li B
Drug Design, Development and Therapy 2018, 12:3899-3912
Published Date: 13 November 2018
CTL019 (tisagenlecleucel): CAR-T therapy for relapsed and refractory B-cell acute lymphoblastic leukemia
Vairy S, Lopes Garcia J, Teira P, Bittencourt H
Drug Design, Development and Therapy 2018, 12:3885-3898
Published Date: 12 November 2018
Risankizumab: an anti-IL-23 antibody for the treatment of psoriasis
Haugh IM, Preston AK, Kivelevitch DN, Menter AM
Drug Design, Development and Therapy 2018, 12:3879-3883
Published Date: 12 November 2018
The therapeutic effects of traditional Chinese medicine Fusu agent in LPS-induced acute lung injury model rats
Gao P, Zhao Z, Zhang C, Wang C, Long K, Guo L, Li B
Drug Design, Development and Therapy 2018, 12:3867-3878
Published Date: 13 November 2018
A new strategy for taste masking of azithromycin antibiotic: development, characterization, and evaluation of azithromycin titanium nanohybrid for masking of bitter taste using physisorption and panel testing studies
Amin F, Khan S, Shah SMH, Rahim H, Hussain Z, Sohail M, Ullah R, Alsaid MS, Shahat AA
Drug Design, Development and Therapy 2018, 12:3855-3866
Published Date: 8 November 2018
Notch inhibitor can attenuate apparent diffusion coefficient and improve neurological function through downregulating NOX2-ROS in severe traumatic brain injury
Zhang HM, Chen W, Liu RN, Zhao Y
Drug Design, Development and Therapy 2018, 12:3847-3854
Published Date: 8 November 2018
The effects of macrolides in children with reactive airway disease: a systematic review and meta-analysis of randomized controlled trials
Lei WT, Lin HH, Tsai MC, Hung HH, Cheng YJ, Liu SJ, Lin CY, Yeh TL
Drug Design, Development and Therapy 2018, 12:3825-3845
Published Date: 8 November 2018
The effects of vasoactive intestinal peptide in the rat model of experimental autoimmune neuritis and the implications for treatment of acute inflammatory demyelinating polyradiculoneuropathy or Guillain–Barré syndrome
Jiao H, Ren H
Drug Design, Development and Therapy 2018, 12:3817-3824
Published Date: 6 November 2018
An insight into new strategies to combat antifungal drug resistance
Zheng YH, Ma YY, Ding Y, Chen XQ, Gao GX
Drug Design, Development and Therapy 2018, 12:3807-3816
Published Date: 5 November 2018
Comparative pharmacokinetics of an adalimumab biosimilar SB5 administered via autoinjector or prefilled syringe in healthy subjects
Shin D, Lee Y, Jeong D, Ellis-Pegler R
Drug Design, Development and Therapy 2018, 12:3799-3805
Published Date: 5 November 2018
The effect of food and liquid pH on the integrity of enteric-coated beads from cysteamine bitartrate delayed-release capsules [Corrigendum]
Pavloff N, Hauser TA, Williams C, Isbell SL, Cadieux B, Johnson M
Drug Design, Development and Therapy 2018, 12:3797-3798
Published Date: 5 November 2018
Histopathological study of liver tissue due to methadone consumption and its effect on liver enzymes and inflammatory indices in rat
Amraei M, Mohamadpour M, Hafezi Ahmadi MR, Azizi M, Daemi A, Omidi M, Shirzadpour E
Drug Design, Development and Therapy 2018, 12:3785-3795
Published Date: 5 November 2018
Effect of intrathecal dexmedetomidine on preventing shivering in cesarean section after spinal anesthesia: a meta-analysis and trial sequential analysis
Miao S, Shi M, Zou L, Wang G
Drug Design, Development and Therapy 2018, 12:3775-3783
Published Date: 2 November 2018
Concomitant food intake does not affect the efficacy of entecavir in chronic hepatitis B patients with virological response: a randomized, multicenter, noninferiority trial
Cho EJ, Yu SJ, Kwon SY, Kim JH, Kim DY, Kim W, Lee JS, Lee JW, Lee YJ, Chae HB, Yoon JH
Drug Design, Development and Therapy 2018, 12:3767-3774
Published Date: 2 November 2018
Hydralazine HCl rapidly disintegrating sublingual tablets: simple dosage form of higher bioavailability and enhanced clinical efficacy for potential rapid control on hypertensive preeclampsia
Genedy S, Khames A, Hussein A, Sarhan H
Drug Design, Development and Therapy 2018, 12:3753-3766
Published Date: 5 November 2018
Identification of new inhibitors of Mdm2–p53 interaction via pharmacophore and structure-based virtual screening
Atatreh N, Ghattas MA, Bardaweel SK, Al Rawashdeh S, Al Sorkhy M
Drug Design, Development and Therapy 2018, 12:3741-3752
Published Date: 2 November 2018
Two-drug regimens for treatment of naïve HIV-1 infection and as maintenance therapy
Corado KC, Caplan MR, Daar ES
Drug Design, Development and Therapy 2018, 12:3731-3740
Published Date: 1 November 2018
Efficacy evaluation of reteplase in a novel canine acute pulmonary thromboembolism model developed by minimally invasive surgery and digital subtraction angiography
Zhang Y, Liu H, Zhang Y, Wu Q, Zhang Y, Zhang J, Zhou X, Jiao H, Fan F, Xue Q, Wang X, Zhong Z
Drug Design, Development and Therapy 2018, 12:3717-3730
Published Date: 1 November 2018
Saponins enhance exon skipping of 2′-O-methyl phosphorothioate oligonucleotide in vitro and in vivo
Wang M, Wu B, Shah SN, Lu P, Lu Q
Drug Design, Development and Therapy 2018, 12:3705-3715
Published Date: 31 October 2018
Arminin 1a-C, a novel antimicrobial peptide from ancient metazoan Hydra, shows potent antileukemia activity against drug-sensitive and drug-resistant leukemia cells
Liang X, Wang R, Dou W, Zhao L, Zhou L, Zhu J, Wang K, Yan J
Drug Design, Development and Therapy 2018, 12:3691-3703
Published Date: 31 October 2018
Meta-analysis of rosuvastatin efficacy in prevention of contrast-induced acute kidney injury
Zhang J, Guo Y, Jin Q, Bian L, Lin P
Drug Design, Development and Therapy 2018, 12:3685-3690
Published Date: 31 October 2018
Formononetin induces vasorelaxation in rat thoracic aorta via regulation of the PI3K/PTEN/Akt signaling pathway
Li T, Zhong Y, Tang T, Luo J, Cui H, Fan R, Wang Y, Wang D
Drug Design, Development and Therapy 2018, 12:3675-3684
Published Date: 1 November 2018
Efficacy and safety of Tongfu powder in acute pancreatitis patients with gastrointestinal dysfunction: a clinical trial
Miao B, Li FW, Zhang SW, Wang H, Qi WJ, Wang C
Drug Design, Development and Therapy 2018, 12:3665-3673
Published Date: 31 October 2018
Pharmacokinetic evaluation of a transdermal anastrozole-in-adhesive formulation
Regenthal R, Voskanian M, Baumann F, Teichert J, Brätter C, Aigner A, Abraham G
Drug Design, Development and Therapy 2018, 12:3653-3664
Published Date: 1 November 2018
Transfer of rosuvastatin into breast milk: liquid chromatography–mass spectrometry methodology and clinical recommendations
Lwin EMP, Leggett C, Ritchie U, Gerber C, Song Y, Hague W, Turner S, Upton R, Garg S
Drug Design, Development and Therapy 2018, 12:3645-3651
Published Date: 29 October 2018
Darunavir–cobicistat–emtricitabine–tenofovir alafenamide: safety and efficacy of a protease inhibitor in the modern era
Squillace N, Bozzi G, Colella E, Gori A, Bandera A
Drug Design, Development and Therapy 2018, 12:3635-3643
Published Date: 29 October 2018
Clinical effectiveness of ranibizumab and conbercept for neovascular age-related macular degeneration: a meta-analysis
Wang LP, Zhang CW, Hua R
Drug Design, Development and Therapy 2018, 12:3625-3633
Published Date: 29 October 2018
Dexmedetomidine protects the developing rat brain against the neurotoxicity wrought by sevoflurane: role of autophagy and Drp1–Bax signaling
Shan Y, Sun S, Yang F, Shang N, Liu H
Drug Design, Development and Therapy 2018, 12:3617-3624
Published Date: 30 October 2018
Pharmacokinetic and bioequivalence study comparing a fimasartan/rosuvastatin fixed-dose combination with the concomitant administration of fimasartan and rosuvastatin in healthy subjects
Kang WY, Seong SJ, Ohk B, Gwon MR, Kim BK, Cho S, Shim WS, Lee KT, Kim EH, Yang DH, Lee HW, Yoon YR
Drug Design, Development and Therapy 2018, 12:3607-3615
Published Date: 26 October 2018
Asiatic acid ameliorates CC l4-induced liver fibrosis in rats: involvement of Nrf2/ARE, NF-κB/IκBα, and JAK1/STAT3 signaling pathways
Fan J, Chen Q, Wei L, Zhou X, Wang R, Zhang H
Drug Design, Development and Therapy 2018, 12:3595-3605
Published Date: 26 October 2018
Effect and safety of antithrombotic therapies for secondary prevention after acute coronary syndrome: a network meta-analysis
Mo FR, Li J, Yan YL, Wu WF, Lai SY
Drug Design, Development and Therapy 2018, 12:3583-3594
Published Date: 25 October 2018
Asiatic acid protests against myocardial ischemia/reperfusion injury via modulation of glycometabolism in rat cardiomyocyte
Dai Y, Wang Z, Quan M, Lv Y, Li Y, Xin HB, Qian Y
Drug Design, Development and Therapy 2018, 12:3573-3582
Published Date: 25 October 2018
Lobaplatin inhibits breast cancer progression, cell proliferation while it induces cell apoptosis by downregulating MTDH expression
Tian W, Hao S, Gao B, Jiang Y, Zhang X, Zhang S, Guo L, Zhao J, Zhang G, Chen Y, Li Z, Luo D
Drug Design, Development and Therapy 2018, 12:3563-3571
Published Date: 29 October 2018
Entrectinib and other ALK/TRK inhibitors for the treatment of neuroblastoma
Pacenta HL, Macy ME
Drug Design, Development and Therapy 2018, 12:3549-3561
Published Date: 23 October 2018
Glutathione S-transferase π: a potential role in antitumor therapy
Dong S, Sha H, Xu X, Hu T, Lou R, Li H, Wu J, Dan C, Feng J
Drug Design, Development and Therapy 2018, 12:3535-3547
Published Date: 23 October 2018
Antioxidative stress effects of vitamins C, E, and B12, and their combination can protect the liver against acetaminophen-induced hepatotoxicity in rats
Abdulkhaleq FM, Alhussainy TM, Badr MM, Abu Khalil AA, Gammoh O, Ghanim BY, Qinna NA
Drug Design, Development and Therapy 2018, 12:3525-3533
Published Date: 18 October 2018
Combination of Ginsenoside Rg1 and Astragaloside IV reduces oxidative stress and inhibits TGF-β1/Smads signaling cascade on renal fibrosis in rats with diabetic nephropathy
Du N, Xu Z, Gao M, Liu P, Sun B, Cao X
Drug Design, Development and Therapy 2018, 12:3517-3524
Published Date: 18 October 2018
Intranasal niosomes of nefopam with improved bioavailability: preparation, optimization, and in-vivo evaluation
Abou-Taleb HA, Khallaf RA, Abdel-Aleem JA
Drug Design, Development and Therapy 2018, 12:3501-3516
Published Date: 17 October 2018
Enhanced oral bioavailability of fluvastatin by using nanosuspensions containing cyclodextrin
Li J, Yang M, Xu WR
Drug Design, Development and Therapy 2018, 12:3491-3499
Published Date: 23 October 2018
The retinoprotective role of phenytoin
Bartollino S, Chiosi F, di Staso S, Uva M, Pascotto A, Rinaldi M, Keppel Hesselink JM, Costagliola C
Drug Design, Development and Therapy 2018, 12:3485-3489
Published Date: 16 October 2018
The efficacy and safety of aflibercept and conbercept in diabetic macular edema
Cai S, Yang Q, Li X, Zhang Y
Drug Design, Development and Therapy 2018, 12:3471-3483
Published Date: 15 October 2018
Realgar, a traditional Chinese medicine, induces apoptosis of HPV16-positive cervical cells through a HPV16 E7-related pathway
Ding W, Ji T, Xiong W, Li T, Pu D, Liu R
Drug Design, Development and Therapy 2018, 12:3459-3469
Published Date: 15 October 2018
Dose-proportional pharmacokinetic properties of GLA5PR GLARS-NF1 controlled-release pregabalin in healthy Korean volunteers: a randomized, open, single-dose, parallel study
Shin KH, Jeon JY, Jang K, Kim TE, Kim MG
Drug Design, Development and Therapy 2018, 12:3449-3457
Published Date: 11 October 2018
miR-708-5p promotes fibroblast–like synoviocytes' cell apoptosis and ameliorates rheumatoid arthritis by inhibition of Wnt3a/β-catenin pathway
Wu J, Fan W, Ma L, Geng X
Drug Design, Development and Therapy 2018, 12:3439-3447
Published Date: 10 October 2018
Inhibition of sialidase activity as a therapeutic approach
Glanz VY, Myasoedova VA, Grechko AV, Orekhov AN
Drug Design, Development and Therapy 2018, 12:3431-3437
Published Date: 10 October 2018
All-trans retinoic acid can antagonize osteoblastogenesis induced by different BMPs irrespective of their dimerization types and dose-efficiencies
Liu Y, Ma X, Guo J, Lin Z, Zhou M, Bi W, Liu J, Wang J, Lu H, Wu G
Drug Design, Development and Therapy 2018, 12:3419-3430
Published Date: 10 October 2018
Shensong Yangxin capsule reduces atrial fibrillation susceptibility by inhibiting atrial fibrosis in rats with post-myocardial infarction heart failure
Ma J, Yin C, Ma S, Qiu H, Zheng C, Chen Q, Ding C, Lv W
Drug Design, Development and Therapy 2018, 12:3407-3418
Published Date: 10 October 2018
Synthesis and anticancer activity of dimeric podophyllotoxin derivatives
Zi C, Yang L, Xu F, Dong F, Yang D, Li Y, Ding Z, Zhou J, Jiang Z, Hu J
Drug Design, Development and Therapy 2018, 12:3393-3406
Published Date: 9 October 2018
Immediate release tablet formulation of varenicline salicylate and comparative pharmacokinetic study in human volunteers
Kwak SS, Lee ES, Yoon HY, Kim CH, Goo YT, Kang MJ, Lee S, Lee BS, Jeon HR, Oh CH, Choi YW
Drug Design, Development and Therapy 2018, 12:3377-3392
Published Date: 9 October 2018
Utility of nintedanib for severe idiopathic pulmonary fibrosis: a single-center retrospective study
Abe M, Tsushima K, Sakayori M, Suzuki K, Ikari J, Terada J, Tatsumi K
Drug Design, Development and Therapy 2018, 12:3369-3375
Published Date: 9 October 2018
RETRACTED ARTICLE: Therapeutic effects of tyroserleutide on lung metastasis of human hepatocellular carcinoma SK-HEP-1 and its mechanism affecting ICAM-1 and MMP-2 and -9
Che X, Lu R, Fu Z, Sun Y, Zhu Z, Li J, Wang S, Jia J, Wang Q, Yao Z
Drug Design, Development and Therapy 2018, 12:3357-3368
Published Date: 9 October 2018
Characterization of clinical grade CD19 chimeric antigen receptor T cells produced using automated CliniMACS prodigy system
Zhang W, Jordan KR, Schulte B, Purev E
Drug Design, Development and Therapy 2018, 12:3343-3356
Published Date: 5 October 2018
Indirubin suppresses ovarian cancer cell viabilities through the STAT3 signaling pathway
Chen L, Wang J, Wu J, Zheng Q, Hu J
Drug Design, Development and Therapy 2018, 12:3335-3342
Published Date: 4 October 2018
Gastric cancer combination therapy: synthesis of a hyaluronic acid and cisplatin containing lipid prodrug coloaded with sorafenib in a nanoparticulate system to exhibit enhanced anticancer efficacy and reduced toxicity
Yang F, Li A, Liu H, Zhang H
Drug Design, Development and Therapy 2018, 12:3321-3333
Published Date: 4 October 2018
Pretreatment with lidocaine reduces both incidence and severity of etomidate-induced myoclonus: a meta-analysis of randomized controlled trials
Lang B, Zhang L, Yang C, Lin Y, Zhang W, Li F
Drug Design, Development and Therapy 2018, 12:3311-3319
Published Date: 4 October 2018
Evaluation of methotrexate-conjugated gadolinium(III) for cancer diagnosis and treatment
Xu D, Lu ST, Li YS, Baidya A, Mei H, He Y, Wu B
Drug Design, Development and Therapy 2018, 12:3301-3309
Published Date: 5 October 2018
Pleiotropic effects and pharmacological properties of penehyclidine hydrochloride
Wang Y, Gao Y, Ma J
Drug Design, Development and Therapy 2018, 12:3289-3299
Published Date: 5 October 2018
α-hemihydrate calcium sulfate/octacalcium phosphate combined with sodium hyaluronate promotes bone marrow-derived mesenchymal stem cell osteogenesis in vitro and in vivo
Chen C, Zhu C, Hu X, Yu Q, Zheng Q, Tao S, Fan L
Drug Design, Development and Therapy 2018, 12:3269-3287
Published Date: 2 October 2018
Effect of butorphanol on opioid-induced cough: a meta-analysis of randomized controlled trials
Zhang J, Miao S, Tu Q, Shi M, Zou L, Liu S, Wang G
Drug Design, Development and Therapy 2018, 12:3263-3268
Published Date: 2 October 2018
Baicalin suppresses proliferation, migration, and invasion in human glioblastoma cells via Ca2+-dependent pathway
Zhu Y, Fang J, Wang H, Fei M, Tang T, Liu K, Niu W, Zhou Y
Drug Design, Development and Therapy 2018, 12:3247-3261
Published Date: 2 October 2018
Copper-64: a real theranostic agent
Gutfilen B, Souza SAL, Valentini G
Drug Design, Development and Therapy 2018, 12:3235-3245
Published Date: 2 October 2018
Lactobacilli with superoxide dismutase-like or catalase activity are more effective in alleviating inflammation in an inflammatory bowel disease mouse model
Tomusiak-Plebanek A, Heczko P, Skowron B, Baranowska A, Okoń K, Thor PJ, Strus M
Drug Design, Development and Therapy 2018, 12:3221-3233
Published Date: 28 September 2018
Lycium barbarum polysaccharide prevents cisplatin-induced MLTC-1 cell apoptosis and autophagy via regulating endoplasmic reticulum stress pathway
Yang F, Wei Y, Liao B, Wei G, Qin H, Pang X, Wang J
Drug Design, Development and Therapy 2018, 12:3211-3219
Published Date: 26 September 2018
Synergistic combination therapy of lung cancer using paclitaxel- and triptolide-coloaded lipid–polymer hybrid nanoparticles
Liu J, Cheng H, Han L, Qiang Z, Zhang X, Gao W, Zhao K, Song Y
Drug Design, Development and Therapy 2018, 12:3199-3209
Published Date: 25 September 2018
Design and development of Nrf2 modulators for cancer chemoprevention and therapy: a review
Sova M, Saso L
Drug Design, Development and Therapy 2018, 12:3181-3197
Published Date: 25 September 2018
Colorectal cancer combination therapy using drug and gene co-delivered, targeted poly(ethylene glycol)-ε-poly(caprolactone) nanocarriers
Wang Z, Wei Y, Fang G, Hong D, An L, Jiao T, Shi Y, Zang A
Drug Design, Development and Therapy 2018, 12:3171-3180
Published Date: 24 September 2018
Intravenous tranexamic acid use in revision total joint arthroplasty: a meta-analysis
Kuo FC, Lin PY, Wang JW, Lin PC, Lee MS, Chen AF
Drug Design, Development and Therapy 2018, 12:3163-3170
Published Date: 24 September 2018
Profile of asfotase alfa in the treatment of hypophosphatasia: design, development, and place in therapy
Bowden SA, Foster BL
Drug Design, Development and Therapy 2018, 12:3147-3161
Published Date: 24 September 2018
Current development of biodegradable polymeric materials for biomedical applications
Song R, Murphy M, Li C, Ting K, Soo C, Zheng Z
Drug Design, Development and Therapy 2018, 12:3117-3145
Published Date: 24 September 2018
Murrangatin suppresses angiogenesis induced by tumor cell–derived media and inhibits AKT activation in zebrafish and endothelial cells
Long W, Wang M, Luo X, Huang G, Chen J
Drug Design, Development and Therapy 2018, 12:3107-3115
Published Date: 24 September 2018
A targeted therapy for melanoma by graphene oxide composite with microRNA carrier
Liu C, Xie H, Yu JG, Chen X, Tang S, Sun L, Chen X, Peng D, Zhang X, Zhou J
Drug Design, Development and Therapy 2018, 12:3095-3106
Published Date: 21 September 2018
Comparison of the efficacy and survival analysis of neoadjuvant chemotherapy for Her-2-positive breast cancer
Li S, Wei W, Jiang Y, Li Q, Huang Q, Yang H, Liu J
Drug Design, Development and Therapy 2018, 12:3085-3093
Published Date: 21 September 2018
Glucosamine-paracetamol spray-dried solid dispersions with maximized intrinsic dissolution rate, bioavailability and decreased levels of in vivo toxic metabolites
Ali AMA, Khames A, Alrobaian MM, Hamaidi M, Abourehab MAS
Drug Design, Development and Therapy 2018, 12:3071-3084
Published Date: 21 September 2018
Effects of hydroxyethyl starch 130/0.4 on the kidney tissue of rats with ureteral obstruction
Güneş I, Süngü N, Kılıçarslan A, Şıvgın V, Alkan M, Küçük A, Boyunağa H, Ünal Y, Arslan M
Drug Design, Development and Therapy 2018, 12:3061-3070
Published Date: 20 September 2018
Chemotherapeutic drug targeting to lungs by way of microspheres after intravenous administration
Sangi S, SreeHarsha N, Bawadekji A, Al Ali M
Drug Design, Development and Therapy 2018, 12:3051-3060
Published Date: 18 September 2018
Fatal adverse events with molecular targeted agents in the treatment of advanced hepatocellular carcinoma: a meta-analysis of randomized controlled trials
Li X, Wan J, Wu Z, Tu J, Hu Y, Wu S, Lou L
Drug Design, Development and Therapy 2018, 12:3043-3049
Published Date: 18 September 2018
Sintered dicalcium pyrophosphate treatment attenuates estrogen deficiency-associated disc degeneration in ovariectomized rats
Chen CH, Chen WC, Lin CY, Chen CH, Tsuang YH, Kuo YJ
Drug Design, Development and Therapy 2018, 12:3033-3041
Published Date: 18 September 2018
Zoledronate inhibits fibroblasts’ proliferation and activation via targeting TGF-β signaling pathway
Zhao Z, Shen W, Zhu H, Lin L, Jiang G, Zhu Y, Song H, Wu L
Drug Design, Development and Therapy 2018, 12:3021-3031
Published Date: 17 September 2018
Risk of selected gastrointestinal toxicities associated with poly (ADP-ribose) polymerase (PARP) inhibitors in the treatment of ovarian cancer: a meta-analysis of published trials
Liu Y, Meng J, Wang G
Drug Design, Development and Therapy 2018, 12:3013-3019
Published Date: 17 September 2018
The role of hypoxia-inducible factor stabilizers in the treatment of anemia in patients with chronic kidney disease
Zhong H, Zhou T, Li H, Zhong Z
Drug Design, Development and Therapy 2018, 12:3003-3011
Published Date: 18 September 2018
Novel anti-inflammatory film as a delivery system for the external medication with bioactive phytochemical “Apocynin”
Anter HM, Abu Hashim II, Awadin W, Meshali MM
Drug Design, Development and Therapy 2018, 12:2981-3001
Published Date: 13 September 2018
Astragaloside IV represses high glucose-induced mesangial cells activation by enhancing autophagy via SIRT1 deacetylation of NF-κB P65 subunit
Wang X, Gao Y, Tian N, Zhu Z, Wang T, Xu J, Wu B, Zhang N
Drug Design, Development and Therapy 2018, 12:2971-2980
Published Date: 12 September 2018
The long-term effect of tacrolimus on alkali burn-induced corneal neovascularization and inflammation surpasses that of anti-vascular endothelial growth factor
Chen L, Zhong J, Li S, Li W, Wang B, Deng Y, Yuan J
Drug Design, Development and Therapy 2018, 12:2959-2969
Published Date: 12 September 2018
Saikosaponin A modulates remodeling of Kv4.2-mediated A-type voltage-gated potassium currents in rat chronic temporal lobe epilepsy
Hong Y, Deng N, Jin H, Xuan Z, Qian YX, Wu ZY, Xie W
Drug Design, Development and Therapy 2018, 12:2945-2958
Published Date: 11 September 2018
GlycoPEGylated recombinant factor IX for hemophilia B in context
Santagostino E, Mancuso ME
Drug Design, Development and Therapy 2018, 12:2933-2943
Published Date: 11 September 2018
Papaverine hydrochloride containing nanostructured lyotropic liquid crystal formulation as a potential drug delivery system for the treatment of erectile dysfunction
Berkó S, Zsikó S, Deák G, Gácsi A, Kovács A, Budai-Szűcs M, Pajor L, Bajory Z, Csányi E
Drug Design, Development and Therapy 2018, 12:2923-2931
Published Date: 12 September 2018
In vitro and in vivo evaluation of cephalosporins for the treatment of Lyme disease
Pothineni VR, Parekh MB, Babar MM, Ambati A, Maguire P, Inayathullah M, Kim K, Tayebi L, Potula HS, Rajadas J
Drug Design, Development and Therapy 2018, 12:2915-2921
Published Date: 11 September 2018
Chemopreventive activity of sulforaphane
Jiang X, Liu Y, Ma L, Ji R, Qu Y, Xin Y, Lv G
Drug Design, Development and Therapy 2018, 12:2905-2913
Published Date: 11 September 2018
Geraniol suppresses proinflammatory mediators in phorbol 12-myristate 13-acetate with A23187-induced HMC-1 cells
Huang Y, Yang XL, Ni YH, Xu ZM
Drug Design, Development and Therapy 2018, 12:2897-2903
Published Date: 11 September 2018
Inhibitor of IGF1 receptor alleviates the inflammation process in the diabetic kidney mouse model without activating SOCS2
Li J, Dong R, Yu J, Yi S, Da J, Yu F, Zha Y
Drug Design, Development and Therapy 2018, 12:2887-2896
Published Date: 11 September 2018
Eremomycin pyrrolidide: a novel semisynthetic glycopeptide with improved chemotherapeutic properties
Olsufyeva EN, Shchekotikhin AE, Bychkova EN, Pereverzeva ER, Treshalin ID, Mirchink EP, Isakova EB, Chernobrovkin MG, Kozlov RS, Dekhnich AV, Preobrazhenskaya MN
Drug Design, Development and Therapy 2018, 12:2875-2885
Published Date: 10 September 2018
Profile of atezolizumab in the treatment of metastatic non-small-cell lung cancer: patient selection and perspectives
Facchinetti F, Bordi P, Leonetti A, Buti S, Tiseo M
Drug Design, Development and Therapy 2018, 12:2857-2873
Published Date: 10 September 2018
Anti-HER2 functionalized graphene oxide as survivin-siRNA delivery carrier inhibits breast carcinoma growth in vitro and in vivo
Wang X, Sun Q, Cui C, Li J, Wang Y
Drug Design, Development and Therapy 2018, 12:2841-2855
Published Date: 7 September 2018
Alpha lipoic acid combined with epalrestat: a therapeutic option for patients with diabetic peripheral neuropathy
Wang XT, Lin HX, Xu S, Jin YL, Zhang R
Drug Design, Development and Therapy 2018, 12:2827-2840
Published Date: 7 September 2018
Preliminary study on conjugation of formononetin with multiwalled carbon nanotubes for inducing apoptosis via ROS production in HeLa cells
Guo B, Liao C, Liu X, Yi J
Drug Design, Development and Therapy 2018, 12:2815-2826
Published Date: 7 September 2018
Macrocyclic lactones inhibit nasopharyngeal carcinoma cells proliferation through PAK1 inhibition and reduce in vivo tumor growth
Gallardo F, Mariamé B, Gence R, Tilkin-Mariamé AF
Drug Design, Development and Therapy 2018, 12:2805-2814
Published Date: 7 September 2018
The effect of food and liquid pH on the integrity of enteric-coated beads from cysteamine bitartrate delayed-release capsules
Pavloff N, Hauser TA, Williams C, Isbell SL, Cadieux B, Johnson M
Drug Design, Development and Therapy 2018, 12:2795-2804
Published Date: 6 September 2018
Astragaloside IV/lncRNA-TUG1/TRAF5 signaling pathway participates in podocyte apoptosis of diabetic nephropathy rats
Lei X, Zhang L, Li Z, Ren J
Drug Design, Development and Therapy 2018, 12:2785-2793
Published Date: 6 September 2018
Efficacy and safety of a fixed-dose combination of nimesulide/pantoprazole compared to naproxen/esomeprazole for pain relief in patients with osteoarticular diseases and dyspeptic symptoms
Scheinberg M, Pott Júnior H, Macêdo EA, Bocchi de Oliveira MF, Ecclissato C, Amazonas RB
Drug Design, Development and Therapy 2018, 12:2775-2783
Published Date: 6 September 2018
Are laboratory parameter (biomarker) values similar to the healthy volunteer reference range in all patient populations?
Brott DA, Goodman MJ, Hermann RP, Merz M, Calvo R, Poorkhalkali N, Kiazand A
Drug Design, Development and Therapy 2018, 12:2757-2773
Published Date: 6 September 2018
Safety and efficacy of elbasvir/grazoprevir for the treatment of chronic hepatitis C: current evidence
Morikawa K, Nakamura A, Shimazaki T, Sakamoto N
Drug Design, Development and Therapy 2018, 12:2749-2756
Published Date: 5 September 2018
Dingchuan tang essential oil inhibits the production of inflammatory mediators via suppressing the IRAK/NF-κB, IRAK/AP-1, and TBK1/IRF3 pathways in lipopolysaccharide-stimulated RAW264.7 cells
Zhang Y, Guo H, Cheng BCY, Su T, Fu XQ, Li T, Zhu PL, Tse KW, Pan SY, Yu ZL
Drug Design, Development and Therapy 2018, 12:2731-2748
Published Date: 4 September 2018
17β-estradiol ameliorates oxidative stress and blue light-emitting diode-induced retinal degeneration by decreasing apoptosis and enhancing autophagy
Wei Q, Liang X, Peng Y, Yu D, Zhang R, Jin H, Fan J, Cai W, Ren C, Yu J
Drug Design, Development and Therapy 2018, 12:2715-2730
Published Date: 4 September 2018
Fasudil inhibits actin polymerization and collagen synthesis and induces apoptosis in human urethral scar fibroblasts via the Rho/ROCK pathway
Li XD, Wu YP, Chen SH, Liang YC, Lin TT, Lin T, Wei Y, Xue XY, Zheng QS, Xu N
Drug Design, Development and Therapy 2018, 12:2707-2713
Published Date: 3 September 2018
The total alkaloids from Coptis chinensis Franch improve cognitive deficits in type 2 diabetic rats
Li JC, Shen XF, Shao JA, Tao MM, Gu J, Li J, Huang N
Drug Design, Development and Therapy 2018, 12:2695-2706
Published Date: 31 August 2018
Asenapine pharmacokinetics and tolerability in a pediatric population
Dogterom P, Riesenberg R, de Greef R, Dennie J, Johnson M, Pilla Reddy V, Miltenburg AMM, Findling RL, Jakate A, Carrothers TJ, Troyer MD
Drug Design, Development and Therapy 2018, 12:2677-2693
Published Date: 30 August 2018
Profile of pitolisant in the management of narcolepsy: design, development, and place in therapy
Romigi A, Vitrani G, Lo Giudice T, Centonze D, Franco V
Drug Design, Development and Therapy 2018, 12:2665-2675
Published Date: 30 August 2018
Inhibiting eEF-2 kinase-mediated autophagy enhanced the cytocidal effect of AKT inhibitor on human nasopharyngeal carcinoma
Zhao YY, Tian Y, Liu L, Zhan JH, Hou X, Chen X, Zhou T, Huang Y, Zhang L
Drug Design, Development and Therapy 2018, 12:2655-2663
Published Date: 29 August 2018
A novel multifunctional anti-CEA-IL15 molecule displays potent antitumor activities
Liu Y, Wang Y, Xing J, Li Y, Liu J, Wang Z
Drug Design, Development and Therapy 2018, 12:2645-2654
Published Date: 29 August 2018
Efficient drug delivery of β-estradiol encapsulated in Zn-metal–organic framework nanostructures by microwave-assisted coprecipitation method
Ranjbar M, Pardakhty A, Amanatfard A, Asadipour A
Drug Design, Development and Therapy 2018, 12:2635-2643
Published Date: 28 August 2018
Spectroscopic and molecular modeling studies of binding interaction between bovine serum albumin and roflumilast
Wani TA, Bakheit AH, Ansari MN, Al-Majed ARA, Al-Qahtani BM, Zargar S
Drug Design, Development and Therapy 2018, 12:2627-2634
Published Date: 28 August 2018
Fabrication and characterization of dexibuprofen nanocrystals using microchannel fluidic rector
Khan J, Bashir S, Khan MA, Mohammad MA, Isreb M
Drug Design, Development and Therapy 2018, 12:2617-2626
Published Date: 29 August 2018
A randomized, double-blind clinical trial of canrenone vs hydrochlorothiazide in addition to angiotensin II receptor blockers in hypertensive type 2 diabetic patients
Derosa G, Gaudio G, Pasini G, D'Angelo A, Maffioli P
Drug Design, Development and Therapy 2018, 12:2611-2616
Published Date: 24 August 2018
Preparation and characterization of pH-sensitive nanoparticles of budesonide for the treatment of ulcerative colitis
Zhou H, Qian H
Drug Design, Development and Therapy 2018, 12:2601-2609
Published Date: 22 August 2018
Efficacy and safety of nicorandil on perioperative myocardial injury in patients undergoing elective percutaneous coronary intervention: results of the PENMIPCI trial
Ye Z, Lu H, Su Q, Long M, Li L
Drug Design, Development and Therapy 2018, 12:2591-2599
Published Date: 22 August 2018
Copanlisib for treatment of B-cell malignancies: the development of a PI3K inhibitor with considerable differences to idelalisib
Krause G, Hassenrück F, Hallek M
Drug Design, Development and Therapy 2018, 12:2577-2590
Published Date: 21 August 2018
Genetically engineered drug rhCNB induces apoptosis and cell cycle arrest in both gastric cancer cells and hepatoma cells
Guo Y, Huang Y, Tian S, Xie X, Xing G, Fu J
Drug Design, Development and Therapy 2018, 12:2567-2575
Published Date: 20 August 2018
MEK inhibitors for the treatment of NRAS mutant melanoma
Sarkisian S, Davar D
Drug Design, Development and Therapy 2018, 12:2553-2565
Published Date: 20 August 2018
Profile of intravenous glyburide for the prevention of cerebral edema following large hemispheric infarction: evidence to date
King ZA, Sheth KN, Kimberly WT, Simard JM
Drug Design, Development and Therapy 2018, 12:2539-2552
Published Date: 15 August 2018
Development of prednisolone-containing eye drop formulations by cyclodextrin complexation and antimicrobial, mucoadhesive biopolymer
Bíró T, Horvát G, Budai-Szűcs M, Csányi E, Urbán E, Facskó A, Szabó-Révész P, Csóka I, Aigner Z
Drug Design, Development and Therapy 2018, 12:2529-2537
Published Date: 15 August 2018
Current research for a vaccine against Lassa hemorrhagic fever virus
Warner BM, Safronetz D, Stein DR
Drug Design, Development and Therapy 2018, 12:2519-2527
Published Date: 14 August 2018
Enhanced oral bioavailability of EGCG using pH-sensitive polymeric nanoparticles: characterization and in vivo investigation on nephrotic syndrome rats
Zhang G, Zhang J
Drug Design, Development and Therapy 2018, 12:2509-2518
Published Date: 14 August 2018
Baicalin provides neuroprotection in traumatic brain injury mice model through Akt/Nrf2 pathway
Fang J, Wang H, Zhou J, Dai W, Zhu Y, Zhou Y, Wang X, Zhou M
Drug Design, Development and Therapy 2018, 12:2497-2508
Published Date: 10 August 2018
Milnacipran poorly modulates pain in patients suffering from fibromyalgia: a randomized double-blind controlled study
Pickering G, Macian N, Delage N, Picard P, Cardot JM, Sickout-Arondo S, Giron F, Dualé C, Pereira B, Marcaillou F
Drug Design, Development and Therapy 2018, 12:2485-2496
Published Date: 10 August 2018
No pharmacokinetic interactions between candesartan and amlodipine following multiple oral administrations in healthy subjects
Kim JR, Kim S, Huh W, Ko JW
Drug Design, Development and Therapy 2018, 12:2475-2483
Published Date: 10 August 2018
Preclinical safety evaluation of hepatic arterial infusion of oncolytic poxvirus
Cho E, Ryu EJ, Jiang F, Jeon UB, Cho M, Kim CH, Kim M, Kim ND, Hwang TH
Drug Design, Development and Therapy 2018, 12:2467-2474
Published Date: 8 August 2018
Systematic review and meta-analysis of the benefit of celecoxib in treating advanced non-small-cell lung cancer
Yi L, Zhang W, Zhang H, Shen J, Zou J, Luo P, Zhang J
Drug Design, Development and Therapy 2018, 12:2455-2466
Published Date: 7 August 2018
Antihyperlipidemic studies of newly synthesized phenolic derivatives: in silico and in vivo approaches
Aqeel MT, ur-Rahman N, Khan A, Ashraf Z, Latif M, Rafique H, Rasheed U
Drug Design, Development and Therapy 2018, 12:2443-2453
Published Date: 9 August 2018
Astragaloside IV improves renal function and fibrosis via inhibition of miR-21-induced podocyte dedifferentiation and mesangial cell activation in diabetic mice
Wang X, Gao Y, Tian N, Zou D, Shi Y, Zhang N
Drug Design, Development and Therapy 2018, 12:2431-2442
Published Date: 6 August 2018
Monitoring antiangiogenesis of bevacizumab in zebrafish
Zhang J, Gao BL, Zhang WC, Qian ZJ, Xiang Y
Drug Design, Development and Therapy 2018, 12:2423-2430
Published Date: 6 August 2018
Sinomenine inhibits the growth of melanoma by enhancement of autophagy via PI3K/AKT/mTOR inhibition
Sun Z, Zheng L, Liu X, Xing W, Liu X
Drug Design, Development and Therapy 2018, 12:2413-2421
Published Date: 6 August 2018
Therapeutic effect of protease-activated receptor 2 agonist SLIGRL-NH2 on loperamide-induced Sprague-Dawley rat constipation model and the related mechanism
Zhang Y, Ge T, Xiang P, Mao H, Tang S, Li A, Lin L, Wei Y
Drug Design, Development and Therapy 2018, 12:2403-2411
Published Date: 1 August 2018
Zafirlukast in combination with pseudohypericin attenuates spinal cord injury and motor function in experimental mice
Chen XG, Hua F, Wang SG, Xu YY, Yue HT, Sun J
Drug Design, Development and Therapy 2018, 12:2389-2402
Published Date: 1 August 2018
Comparison of biosimilar filgrastim with a reference product: pharmacokinetics, pharmacodynamics, and safety profiles in healthy volunteers
Choi C, Yoo BW, Kim CO, Hong T, Jin BH, Seo KS, Jang JY, Park MS
Drug Design, Development and Therapy 2018, 12:2381-2387
Published Date: 1 August 2018
Pharmacological mechanism of roflumilast in the treatment of asthma–COPD overlap
Zhang X, Chen Y, Fan L, Ye J, Fan J, Xu X, You D, Liu S, Chen X, Luo P
Drug Design, Development and Therapy 2018, 12:2371-2379
Published Date: 1 August 2018
Doxorubicin-conjugated dexamethasone induced MCF-7 apoptosis without entering the nucleus and able to overcome MDR-1-induced resistance
Chaikomon K, Chattong S, Chaiya T, Tiwawech D, Sritana-Anant Y, Sereemaspun A, Manotham K
Drug Design, Development and Therapy 2018, 12:2361-2369
Published Date: 1 August 2018
Discovery of nonnucleoside inhibitors of polymerase from infectious pancreatic necrosis virus (IPNV)
Bello-Pérez M, Falco A, Galiano V, Coll J, Perez L, Encinar JA
Drug Design, Development and Therapy 2018, 12:2337-2359
Published Date: 30 July 2018
Role of janus kinase inhibitors in the treatment of alopecia areata
Triyangkulsri K, Suchonwanit P
Drug Design, Development and Therapy 2018, 12:2323-2335
Published Date: 27 July 2018
Care pathways and treatment patterns for patients with heart failure in China: results from a cross-sectional survey
Jackson JDS, Cotton SE, Bruce Wirta S, Proenca CC, Zhang M, Lahoz R, Balas B, Calado FJ
Drug Design, Development and Therapy 2018, 12:2311-2321
Published Date: 26 July 2018
Pharmacokinetic interaction between fimasartan and atorvastatin in healthy male volunteers
Choi Y, Lee S, Jang IJ, Yu KS
Drug Design, Development and Therapy 2018, 12:2301-2309
Published Date: 24 July 2018
Inotuzumab ozogamicin: a CD22 mAb–drug conjugate for adult relapsed or refractory B-cell precursor acute lymphoblastic leukemia
Yurkiewicz IR, Muffly L, Liedtke M
Drug Design, Development and Therapy 2018, 12:2293-2300
Published Date: 24 July 2018
HA/HSA co-modified erlotinib–albumin nanoparticles for lung cancer treatment
Shen Y, Li W
Drug Design, Development and Therapy 2018, 12:2285-2292
Published Date: 23 July 2018
Corticosteroids as adjunctive therapy with antibiotics in the treatment of children with septic arthritis: a meta-analysis
Qin YF, Li ZJ, Li H
Drug Design, Development and Therapy 2018, 12:2277-2284
Published Date: 23 July 2018
Effects of the traditional Chinese medicine baicalein on the viability of random pattern skin flaps in rats
Lin R, Lin J, Li S, Ding J, Wu H, Xiang G, Li S, Huang Y, Lin D, Gao W, Kong J, Xu H, Zhou K
Drug Design, Development and Therapy 2018, 12:2267-2276
Published Date: 23 July 2018
Finasteride nano-transferosomal gel formula for management of androgenetic alopecia: ex vivo investigational approach
Ahmed OAA, Rizg WY
Drug Design, Development and Therapy 2018, 12:2259-2265
Published Date: 23 July 2018
Pharmacodynamic considerations of collateral sensitivity in design of antibiotic treatment regimen
Udekwu KI, Weiss H
Drug Design, Development and Therapy 2018, 12:2249-2257
Published Date: 23 July 2018
Development of novel rosuvastatin nanostructured lipid carriers for oral delivery in an animal model
Li J, Yang M, Xu W
Drug Design, Development and Therapy 2018, 12:2241-2248
Published Date: 20 July 2018
The effects of bisphosphonates on osteoporotic patients after lumbar fusion: a meta-analysis
Liu WB, Zhao WT, Shen P, Zhang FJ
Drug Design, Development and Therapy 2018, 12:2233-2240
Published Date: 17 July 2018
Radiosensitivity enhancement by combined treatment of nimotuzumab and celecoxib on nasopharyngeal carcinoma cells
Huang JF, Yuan XP, Pang QF, Zhang HW, Yu JH, Yang B, Zhou LY, Zhang FZ, Liu FJ
Drug Design, Development and Therapy 2018, 12:2223-2231
Published Date: 16 July 2018
Farnesoid X receptor agonist INT-767 attenuates liver steatosis and inflammation in rat model of nonalcoholic steatohepatitis
Hu YB, Liu XY, Zhan W
Drug Design, Development and Therapy 2018, 12:2213-2221
Published Date: 16 July 2018
Emodin mitigates podocytes apoptosis induced by endoplasmic reticulum stress through the inhibition of the PERK pathway in diabetic nephropathy
Tian N, Gao Y, Wang X, Wu X, Zou D, Zhu Z, Han ZJ, Wang T, Shi Y
Drug Design, Development and Therapy 2018, 12:2195-2211
Published Date: 13 July 2018
Antifungal activity of Cardiospermum halicacabum L. (Sapindaceae) against Trichophyton rubrum occurs through molecular interaction with fungal Hsp90
Gaziano R, Campione E, Iacovelli F, Marino D, Pica F, Di Francesco P, Aquaro S, Menichini F, Falconi M, Bianchi L
Drug Design, Development and Therapy 2018, 12:2185-2193
Published Date: 12 July 2018
Efficacy and safety of apatinib combined with chemotherapy for the treatment of advanced gastric cancer in the Chinese population: a systematic review and meta-analysis
Cheng HG, Sun AX, Guo QB, Zhang YC
Drug Design, Development and Therapy 2018, 12:2173-2183
Published Date: 11 July 2018
Does celecoxib inhibit agomelatine metabolism via CYP2C9 or CYP1A2?
Yasar U
Drug Design, Development and Therapy 2018, 12:2169-2172
Published Date: 11 July 2018
A case report of toxic epidermal necrolysis associated with AZD-9291
Wang J, Cheng XY, Lu Y, Zhou BR
Drug Design, Development and Therapy 2018, 12:2163-2167
Published Date: 11 July 2018
Targeted and synergistic therapy for hepatocellular carcinoma: monosaccharide modified lipid nanoparticles for the co-delivery of doxorubicin and sorafenib
Duan W, Liu Y
Drug Design, Development and Therapy 2018, 12:2149-2161
Published Date: 11 July 2018
Effect of green tea catechins on the pharmacokinetics of digoxin in humans
Kim TE, Shin KH, Park JE, Kim MG, Yun YM, Choi DH, Kwon KJ, Lee J
Drug Design, Development and Therapy 2018, 12:2139-2147
Published Date: 10 July 2018
Development of a tin oxide carrier with mesoporous structure for improving the dissolution rate and oral relative bioavailability of fenofibrate
Bai A, Wu C, Liu X, Lv H, Xu X, Cao Y, Shang W, Hu L, Liu Y
Drug Design, Development and Therapy 2018, 12:2129-2138
Published Date: 10 July 2018
Self-nanomicellizing solid dispersion of edaravone: part II: in vivo assessment of efficacy against behavior deficits and safety in Alzheimer’s disease model
Parikh A, Kathawala K, Li JT, Chen C, Shan Z, Cao X, Wang YJ, Garg S, Zhou XF
Drug Design, Development and Therapy 2018, 12:2111-2128
Published Date: 9 July 2018
Design and development of ICCA as a dual inhibitor of GPIIb/IIIa and P-selectin receptors
Chen H, Lu A, Zhang X, Gui L, Wang YN, Wu J, Feng H, Peng S, Zhao M
Drug Design, Development and Therapy 2018, 12:2097-2110
Published Date: 9 July 2018
Safety and efficacy of durvalumab (MEDI4736) in various solid tumors
Yang H, Shen K, Zhu C, Li Q, Zhao Y, Ma X
Drug Design, Development and Therapy 2018, 12:2085-2096
Published Date: 6 July 2018
Different doses of tenecteplase vs alteplase in thrombolysis therapy of acute ischemic stroke: evidence from randomized controlled trials
Xu N, Chen Z, Zhao C, Xue T, Wu X, Sun X, Wang Z
Drug Design, Development and Therapy 2018, 12:2071-2084
Published Date: 6 July 2018
Self-nanomicellizing solid dispersion of edaravone: part I – oral bioavailability improvement
Parikh A, Kathawala K, Tan CC, Garg S, Zhou XF
Drug Design, Development and Therapy 2018, 12:2051-2069
Published Date: 5 July 2018
Effect of preoperative loading dose ticagrelor and clopidogrel on no-reflow phenomenon during intervention in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention: a systematic review and meta-analysis
Dai W, Ye Z, Li L, Su Q
Drug Design, Development and Therapy 2018, 12:2039-2049
Published Date: 4 July 2018
Comparisons of therapeutic efficacy and safety of ipilimumab plus GM-CSF versus ipilimumab alone in patients with cancer: a meta-analysis of outcomes
Chen P, Chen FC, Zhou BH
Drug Design, Development and Therapy 2018, 12:2025-2038
Published Date: 4 July 2018
Comparison of nocturnal symptoms in advanced Parkinson’s disease patients with sleep disturbances: pramipexole sustained release versus immediate release formulations
Xiang W, Sun YQ, Teoh HC
Drug Design, Development and Therapy 2018, 12:2017-2024
Published Date: 4 July 2018
Efficacy and safety of adalimumab in the treatment of non-infectious uveitis: a meta-analysis and systematic review
Ming S, Xie K, He H, Li Y, Lei B
Drug Design, Development and Therapy 2018, 12:2005-2016
Published Date: 4 July 2018
The possibility of healing alveolar bone defects with simvastatin thermosensitive gel: in vitro/in vivo evaluation
Ruan H, Yu Y, Guo X, Jiang Q, Luo Y
Drug Design, Development and Therapy 2018, 12:1997-2003
Published Date: 4 July 2018
Antiangiogenic cytokines as potential new therapeutic targets for resveratrol in diabetic retinopathy
Popescu M, Bogdan C, Pintea A, Rugină D, Ionescu C
Drug Design, Development and Therapy 2018, 12:1985-1996
Published Date: 3 July 2018
Pharmacokinetics of placental protein 13 after intravenous and subcutaneous administration in rabbits
Drobnjak T, Meiri H, Mandalà M, Huppertz B, Gizurarson S
Drug Design, Development and Therapy 2018, 12:1977-1983
Published Date: 3 July 2018
Gemcitabine hydrochloride microspheres used for intravesical treatment of superficial bladder cancer: a comprehensive in vitro/ex vivo/in vivo evaluation
Karavana SY, Ay Şenyiğit Z, Çalışkan Ç, Sevin G, İlem Özdemir D, Erzurumlu Y, Şen S, Baloğlu E
Drug Design, Development and Therapy 2018, 12:1959-1975
Published Date: 2 July 2018
Daptomycin: a comparison of two intravenous formulations
Frankenfeld C, Mittal S, Melendez Y, Mendez-Vigo L, Lamp KC, Keller KN, Bertolami SR
Drug Design, Development and Therapy 2018, 12:1953-1958
Published Date: 29 June 2018
Mechanism of Yanghe Pingchuan granules treatment for airway remodeling in asthma
Pan LY, Han YQ, Wang YZ, Chen QQ, Wu Y, Sun Y
Drug Design, Development and Therapy 2018, 12:1941-1951
Published Date: 27 June 2018
Computer-aided drug design and inhibitive effect of a novel nitrogenous heterocyclic compound and its mechanism on glioma U251 cells and breast cancer MCF-7 cells
Qian L, Zhu Y
Drug Design, Development and Therapy 2018, 12:1931-1939
Published Date: 27 June 2018
Electroporation-enhanced transdermal diclofenac sodium delivery into the knee joint in a rat model of acute arthritis
Hartmann P, Butt E, Fehér Á, Szilágyi ÁL, Jász KD, Balázs B, Bakonyi M, Berkó S, Erős G, Boros M, Horváth G, Varga E, Csányi E
Drug Design, Development and Therapy 2018, 12:1917-1930
Published Date: 27 June 2018
The mechanism of botulinum A on Raynaud syndrome
Zhou Y, Liu Y, Hao Y, Feng Y, Pan L, Liu W, Li B, Xiao L, Jin L, Nie Z
Drug Design, Development and Therapy 2018, 12:1905-1915
Published Date: 26 June 2018
Modes of cell death induced by tetrahydroisoquinoline-based analogs in MDA-MB-231 breast and A549 lung cancer cell lines
Nel M, Joubert AM, Dohle W, Potter BVL, Theron AE
Drug Design, Development and Therapy 2018, 12:1881-1904
Published Date: 25 June 2018
Senkyunolide A protects neural cells against corticosterone-induced apoptosis by modulating protein phosphatase 2A and α-synuclein signaling
Gong S, Zhang J, Guo Z, Fu W
Drug Design, Development and Therapy 2018, 12:1865-1879
Published Date: 25 June 2018
Additive effect of oral LDD175 to tamsulosin and finasteride in a benign prostate hyperplasia rat model
Choi BR, Kim HK, Soni KK, Karna KK, Lee SW, So I, Park JK
Drug Design, Development and Therapy 2018, 12:1855-1863
Published Date: 22 June 2018
Salidroside ameliorates autophagy and activation of hepatic stellate cells in mice via NF-κB and TGF-β1/Smad3 pathways
Feng J, Chen K, Xia Y, Wu L, Li J, Li S, Wang W, Lu X, Liu T, Guo C
Drug Design, Development and Therapy 2018, 12:1837-1853
Published Date: 22 June 2018
Sevoflurane anaesthesia during pregnancy in mice induces hearing impairment in the offspring
Shen X, Xiao Y, Li W, Chen K, Yu H
Drug Design, Development and Therapy 2018, 12:1827-1836
Published Date: 22 June 2018
Short- versus long-term dual antiplatelet therapy after second-generation drug-eluting stent implantation: a systematic review and meta-analysis of randomized controlled trials
Li H, Guo W, Dai W, Li L
Drug Design, Development and Therapy 2018, 12:1815-1825
Published Date: 22 June 2018
Positives and negatives of nonsteroidal anti-inflammatory drugs in bone healing: the effects of these drugs on bone repair
Lisowska B, Kosson D, Domaracka K
Drug Design, Development and Therapy 2018, 12:1809-1814
Published Date: 21 June 2018
Pharmacokinetics, pharmacodynamics, and tolerability of verinurad, a selective uric acid reabsorption inhibitor, in healthy Japanese and non-Asian male subjects
Hall J, Gillen M, Liu S, Miner JN, Valdez S, Shen Z, Lee C
Drug Design, Development and Therapy 2018, 12:1799-1807
Published Date: 20 June 2018
Design, synthesis, docking, and antimicrobial evaluation of some novel pyrazolo[1,5-a]pyrimidines and their corresponding cycloalkane ring-fused derivatives as purine analogs
Abdallah AEM, Elgemeie GH
Drug Design, Development and Therapy 2018, 12:1785-1798
Published Date: 20 June 2018
Use of levosimendan in the treatment of cerebral vascular vasospasm: a case study
Onichimowski D, Nosek K, Goraj R, Jalali R, Wińska A, Pawlos A, Tuyakov B
Drug Design, Development and Therapy 2018, 12:1777-1783
Published Date: 20 June 2018
Clinical efficacy of nab-paclitaxel in patients with metastatic pancreatic cancer
De Luca R, Blasi L, Alù M, Gristina V, Cicero G
Drug Design, Development and Therapy 2018, 12:1769-1775
Published Date: 19 June 2018
Linezolid: a review of its properties, function, and use in critical care
Hashemian SMR, Farhadi T, Ganjparvar M
Drug Design, Development and Therapy 2018, 12:1759-1767
Published Date: 18 June 2018
Lights and shadows of NSAIDs in bone healing: the role of prostaglandins in bone metabolism
Lisowska B, Kosson D, Domaracka K
Drug Design, Development and Therapy 2018, 12:1753-1758
Published Date: 18 June 2018
Icariside II ameliorates endothelial dysfunction by regulating the MAPK pathway via miR-126/SPRED1 in diabetic human cavernous endothelial cells
Lei H, Li H, Tian L, Li M, Xin Z, Zhang X, Guan R
Drug Design, Development and Therapy 2018, 12:1743-1751
Published Date: 13 June 2018
Cyclooxygenase inhibitors potentiate receptor tyrosine kinase therapies in bladder cancer cells in vitro
Bourn J, Cekanova M
Drug Design, Development and Therapy 2018, 12:1727-1742
Published Date: 13 June 2018
Annatto-derived tocotrienol stimulates osteogenic activity in preosteoblastic MC3T3-E1 cells: a temporal sequential study
Wan Hasan WN, Abd Ghafar N, Chin KY, Ima-Nirwana S
Drug Design, Development and Therapy 2018, 12:1715-1726
Published Date: 13 June 2018
Effect of food on the pharmacokinetic characteristics of a single oral dose of LCB01-0371, a novel oxazolidinone antibiotic
Sunwoo J, Kim YK, Choi Y, Yu KS, Nam H, Cho YL, Yoon S, Chung JY
Drug Design, Development and Therapy 2018, 12:1707-1714
Published Date: 11 June 2018
Atrial natriuretic peptide modified oleate adenosine prodrug lipid nanocarriers for the treatment of myocardial infarction: in vitro and in vivo evaluation
Yu J, Li W, Yu D
Drug Design, Development and Therapy 2018, 12:1697-1706
Published Date: 11 June 2018
Chloroquine and hydroxychloroquine are associated with reduced cardiovascular risk: a systematic review and meta-analysis
Liu D, Li X, Zhang Y, Kwong JSW, Li L, Zhang Y, Xu C, Li Q, Sun X, Tian H, Li S
Drug Design, Development and Therapy 2018, 12:1685-1695
Published Date: 11 June 2018
Pharmacokinetics and pharmacodynamics of linezolid in plasma/cerebrospinal fluid in patients with cerebral hemorrhage after lateral ventricular drainage by Monte Carlo simulation
Wu X, Tang Y, Zhang X, Wu C, Kong L
Drug Design, Development and Therapy 2018, 12:1679-1684
Published Date: 11 June 2018
Burden of heart failure on caregivers in China: results from a cross-sectional survey
Jackson JDS, Cotton SE, Bruce Wirta S, Proenca CC, Zhang M, Lahoz R, Calado FJ
Drug Design, Development and Therapy 2018, 12:1669-1678
Published Date: 8 June 2018
Burden of heart failure on patients from China: results from a cross-sectional survey
Jackson JDS, Cotton SE, Bruce Wirta S, Proenca CC, Zhang M, Lahoz R, Calado FJ
Drug Design, Development and Therapy 2018, 12:1659-1668
Published Date: 8 June 2018
Risk of hematologic toxicities with programmed cell death-1 inhibitors in cancer patients: a meta-analysis of current studies
Sui JD, Wang Y, Wan Y, Wu YZ
Drug Design, Development and Therapy 2018, 12:1645-1657
Published Date: 8 June 2018
The role of IL-1 inhibition in systemic juvenile idiopathic arthritis: current status and future perspectives
Toplak N, Blazina Š, Avčin T
Drug Design, Development and Therapy 2018, 12:1633-1643
Published Date: 8 June 2018
GnRH agonist improves pregnancy outcome in mice with induced adenomyosis by restoring endometrial receptivity
Guo S, Li Z, Yan L, Sun Y, Feng Y
Drug Design, Development and Therapy 2018, 12:1621-1631
Published Date: 7 June 2018
Theaflavin alleviates inflammatory response and brain injury induced by cerebral hemorrhage via inhibiting the nuclear transcription factor kappa β-related pathway in rats
Fu G, Wang H, Cai Y, Zhao H, Fu W
Drug Design, Development and Therapy 2018, 12:1609-1619
Published Date: 12 June 2018
Development and validation of an oxygen dissociation assay, a screening platform for discovering, and characterizing hemoglobin–oxygen affinity modifiers
Patel MP, Siu V, Silva-Garcia A, Xu Q, Li Z, Oksenberg D
Drug Design, Development and Therapy 2018, 12:1599-1607
Published Date: 1 June 2018
Role of etelcalcetide in the management of secondary hyperparathyroidism in hemodialysis patients: a review on current data and place in therapy
Friedl C, Zitt E
Drug Design, Development and Therapy 2018, 12:1589-1598
Published Date: 1 June 2018
AMPK/AS160 mediates tiliroside derivatives-stimulated GLUT4 translocation in muscle cells
Zhang C, Jiang Y, Liu J, Jin M, Qin N, Chen Y, Niu W, Duan H
Drug Design, Development and Therapy 2018, 12:1581-1587
Published Date: 1 June 2018
Optimization of a combined wet milling process in order to produce poly(vinyl alcohol) stabilized nanosuspension
Bartos C, Jójárt-Laczkovich O, Katona G, Budai-Szűcs M, Ambrus R, Bocsik A, Gróf I, Deli MA, Szabó-Révész P
Drug Design, Development and Therapy 2018, 12:1567-1580
Published Date: 31 May 2018
2-Amino-1,3,4-thiadiazole as a potential scaffold for promising antimicrobial agents
Serban G, Stanasel O, Serban E, Bota S
Drug Design, Development and Therapy 2018, 12:1545-1566
Published Date: 31 May 2018
Formulation and in vitro characterization of rifampicin-loaded porous poly (ε-caprolactone) microspheres for sustained skeletal delivery
Mei Q, Luo P, Zuo Y, Li J, Zou Q, Li Y, Jiang D, Wang Y
Drug Design, Development and Therapy 2018, 12:1533-1544
Published Date: 31 May 2018
Incidence and risk of cardiac toxicities in patients with relapsed and refractory multiple myeloma treated with carfilzomib
Zhao F, Yang B, Wang J, Zhang R, Liu J, Yin F, Xu W, He C
Drug Design, Development and Therapy 2018, 12:1525-1531
Published Date: 30 May 2018
5-(Thiophen-2-yl)-1,3,4-thiadiazole derivatives: synthesis, molecular docking and in vitro cytotoxicity evaluation as potential anticancer agents
Gomha SM, Edrees MM, Muhammad ZA, El-Reedy AA
Drug Design, Development and Therapy 2018, 12:1511-1523
Published Date: 30 May 2018
Spotlight on olaparib in the treatment of BRCA-mutated ovarian cancer: design, development and place in therapy
Lorusso D, Tripodi E, Maltese G, Lepori S, Sabatucci I, Bogani G, Raspagliesi F
Drug Design, Development and Therapy 2018, 12:1501-1509
Published Date: 29 May 2018
Examination of the effect of ovarian radiation injury induced by hysterosalpingography on ovarian proliferating cell nuclear antigen and the radioprotective effect of amifostine: an experimental study
Can B, Atilgan R, Pala S, Kuloğlu T, Kiray S, Ilhan N
Drug Design, Development and Therapy 2018, 12:1491-1500
Published Date: 25 May 2018
Pharmacological activities, mechanisms of action, and safety of salidroside in the central nervous system
Zhong ZF, Han J, Zhang JZ, Xiao Q, Hu J, Chen LD
Drug Design, Development and Therapy 2018, 12:1479-1489
Published Date: 24 May 2018
Synthesis and evaluation of ortho-[18F]fluorocelecoxib for COX-2 cholangiocarcinoma imaging
Chang CW, Yeh CN, Chung YH, Chen YR, Tien SW, Chen TW, Farn SS, Huang YC, Yu CS
Drug Design, Development and Therapy 2018, 12:1467-1478
Published Date: 24 May 2018
Sustained curcumin release from PLGA microspheres improves bone formation under diabetic conditions by inhibiting the reactive oxygen species production
Li Y, Zhang ZZ
Drug Design, Development and Therapy 2018, 12:1453-1466
Published Date: 24 May 2018
nab-Paclitaxel/carboplatin in elderly patients with advanced squamous non-small cell lung cancer: a retrospective analysis of a Phase III trial
Gridelli C, Chen T, Ko A, O'Brien ME, Ong TJ, Socinski MA, Postmus PE
Drug Design, Development and Therapy 2018, 12:1445-1451
Published Date: 24 May 2018
In silico and in vivo characterization of cabralealactone, solasodin and salvadorin in a rat model: potential anti-inflammatory agents
Malik A, Arooj M, Butt TT, Zahid S, Zahid F, Jafar TH, Waquar S, Gan SH, Ahmad S, Mirza MU
Drug Design, Development and Therapy 2018, 12:1431-1443
Published Date: 24 May 2018
The role of concomitant methotrexate dosage and maintenance over time in the therapy of rheumatoid arthritis patients treated with adalimumab or etanercept: retrospective analysis of a local registry
Favalli EG, Becciolini A, Biggioggero M, Bertoldi I, Crotti C, Raimondo MG, Marchesoni A
Drug Design, Development and Therapy 2018, 12:1421-1429
Published Date: 24 May 2018
Evaluation of the effects of food on levodropropizine controlled-release tablet and its pharmacokinetic profile in comparison to that of immediate-release tablet
Lee S, Nam KY, Oh J, Lee S, Cho SM, Choi YW, Cho JY, Lee BJ, Hong JH
Drug Design, Development and Therapy 2018, 12:1413-1420
Published Date: 23 May 2018
The anti-cataract molecular mechanism study in selenium cataract rats for baicalin ophthalmic nanoparticles
Li N, Han Z, Li L, Zhang B, Liu Z, Li J
Drug Design, Development and Therapy 2018, 12:1399-1411
Published Date: 23 May 2018
Effects of hemocoagulase agkistrodon on the coagulation factors and its procoagulant activities
Li H, Huang Y, Wu X, Wu T, Cao Y, Wang Q, Qiu Y, Fu W, Zhang Q, Pang J
Drug Design, Development and Therapy 2018, 12:1385-1398
Published Date: 23 May 2018
Antihyperglycemic and anti-inflammatory effects of fermented food paste in high-fat diet and streptozotocin-challenged mice
Zulkawi N, Ng KH, Zamberi NR, Yeap SK, Satharasinghe DA, Tan SW, Ho WY, Abd Rashid NY, Md Lazim MI, Jamaluddin A, Alitheen NB, Long K
Drug Design, Development and Therapy 2018, 12:1373-1383
Published Date: 23 May 2018
REST, not REST4, is a risk factor associated with radiotherapy plus chemotherapy efficacy in glioma
Li C, Zou H, Wang ZF, Tang X, Fan X, Zhang K, Liu J, Li Z
Drug Design, Development and Therapy 2018, 12:1363-1371
Published Date: 22 May 2018
Immature platelets and antiplatelet therapy response to aspirin in Kawasaki disease
Pi L, Che D, Long HF, Fang ZZ, Li JW, Lin SY, Liu YF, Li M, Bao LJ, Li W, Zhang Y, Deng QL, Liu TC, Zhang L, Gu XQ
Drug Design, Development and Therapy 2018, 12:1353-1362
Published Date: 23 May 2018
Assessment of the effects of levosimendan and thymoquinone on lung injury after myocardial ischemia reperfusion in rats
Sezen SC, Kucuk A, Özer A, Kılıç Y, Mardin B, Alkan M, Erkent FD, Arslan M, Ünal Y, Oktar GL, Tosun M
Drug Design, Development and Therapy 2018, 12:1347-1352
Published Date: 22 May 2018
Expression and significance of the Hedgehog signal transduction pathway in oxygen-induced retinal neovascularization in mice
Liu ML, Chen XL, Liu HN, Di Y
Drug Design, Development and Therapy 2018, 12:1337-1346
Published Date: 21 May 2018
Design and preparation of derivatives of oleanolic and glycyrrhetinic acids with cytotoxic properties
Wang R, Li Y, Huai XD, Zheng QX, Wang W, Li HJ, Huai QY
Drug Design, Development and Therapy 2018, 12:1321-1336
Published Date: 21 May 2018
Glycyrrhizic acid ameliorates myocardial ischemic injury by the regulation of inflammation and oxidative state
Xu CL, Liang CH, Sun WX, Chen JD, Chen XH
Drug Design, Development and Therapy 2018, 12:1311-1319
Published Date: 18 May 2018
Vicenin-2 inhibits Wnt/β-catenin signaling and induces apoptosis in HT-29 human colon cancer cell line
Yang D, Zhang X, Zhang W, Rengarajan T
Drug Design, Development and Therapy 2018, 12:1303-1310
Published Date: 18 May 2018
Ozone oxidative postconditioning inhibits oxidative stress and apoptosis in renal ischemia and reperfusion injury through inhibition of MAPK signaling pathway
Wang L, Chen ZY, Liu Y, Du Y, Liu XH
Drug Design, Development and Therapy 2018, 12:1293-1301
Published Date: 21 May 2018
Tanshinol ameliorates CCl4-induced liver fibrosis in rats through the regulation of Nrf2/HO-1 and NF-κB/IκBα signaling pathway
Wang R, Wang J, Song F, Li S, Yuan Y
Drug Design, Development and Therapy 2018, 12:1281-1292
Published Date: 17 May 2018
Efficacy of intra-meibomian gland injection of the anti-VEGF agent bevacizumab for the treatment of meibomian gland dysfunction with lid-margin vascularity
Jiang X, Wang Y, Lv H, Liu Y, Zhang M, Li X
Drug Design, Development and Therapy 2018, 12:1269-1279
Published Date: 16 May 2018
Rapeseed protein-derived antioxidant peptide RAP alleviates renal fibrosis through MAPK/NF-κB signaling pathways in diabetic nephropathy
Zhang M, Yan Z, Bu L, An C, Wang D, Liu X, Zhang J, Yang W, Deng BC, Xie J, Zhang B
Drug Design, Development and Therapy 2018, 12:1255-1268
Published Date: 15 May 2018
Computer-aided design of amino acid-based therapeutics: a review
Farhadi T, Hashemian SM
Drug Design, Development and Therapy 2018, 12:1239-1254
Published Date: 14 May 2018
Treatment of tardive dyskinesia with VMAT-2 inhibitors: a systematic review and meta-analysis of randomized controlled trials
Solmi M, Pigato G, Kane JM, Correll CU
Drug Design, Development and Therapy 2018, 12:1215-1238
Published Date: 14 May 2018
Semen Brassicae ameliorates hepatic fibrosis by regulating transforming growth factor-β1/Smad, nuclear factor-κB, and AKT signaling pathways in rats
Cao S, Zheng B, Chen T, Chang X, Yin B, Huang ZH, Shuai P, Han L
Drug Design, Development and Therapy 2018, 12:1205-1213
Published Date: 11 May 2018
Schisandrin B ameliorated chondrocytes inflammation and osteoarthritis via suppression of NF-κB and MAPK signal pathways
Ran J, Ma C, Xu K, Xu L, He Y, Moqbel SAA, Hu P, Jiang L, Chen W, Bao J, Xiong Y, Wu L
Drug Design, Development and Therapy 2018, 12:1195-1204
Published Date: 9 May 2018
Insight into resistance mechanism of anaplastic lymphoma kinase to alectinib and JH-VIII-157-02 caused by G1202R solvent front mutation
Wang H, Wang Y, Guo W, Du B, Huang X, Wu R, Yang B, Lin X, Wu Y
Drug Design, Development and Therapy 2018, 12:1183-1193
Published Date: 9 May 2018
Update on new biologics for intractable eosinophilic asthma: impact of reslizumab
Sahota J, Robinson DS
Drug Design, Development and Therapy 2018, 12:1173-1181
Published Date: 8 May 2018
Traditional Chinese herbal formula relieves snoring by modulating activities of upper airway related nerves in aged rats
Chung KT, Hsu CH, Lin CL, Wang SE, Wu CH
Drug Design, Development and Therapy 2018, 12:1165-1171
Published Date: 8 May 2018
Pharmacokinetic comparison of a fixed-dose combination versus concomitant administration of fimasartan, amlodipine, and rosuvastatin using partial replicated design in healthy adult subjects
Oh M, Ghim JL, Park SE, Kim EY, Shin JG
Drug Design, Development and Therapy 2018, 12:1157-1164
Published Date: 8 May 2018
The cytochrome P450 isoenzyme and some new opportunities for the prediction of negative drug interaction in vivo
Sychev DA, Ashraf GM, Svistunov AA, Maksimov ML, Tarasov VV, Chubarev VN, Otdelenov VA, Denisenko NP, Barreto GE, Aliev G
Drug Design, Development and Therapy 2018, 12:1147-1156
Published Date: 8 May 2018
Identification of novel drug targets in bovine respiratory disease: an essential step in applying biotechnologic techniques to develop more effective therapeutic treatments
Sakharkar MK, Rajamanickam K, Chandra R, Khan HA, Alhomida AS, Yang J
Drug Design, Development and Therapy 2018, 12:1135-1146
Published Date: 7 May 2018
Inhibition of human prostate cancer (PC-3) cells and targeting of PC-3-derived prostate cancer stem cells with koenimbin, a natural dietary compound from Murraya koenigii (L) Spreng
Kamalidehghan B, Ghafouri-Fard S, Motevaseli E, Ahmadipour F
Drug Design, Development and Therapy 2018, 12:1119-1133
Published Date: 4 May 2018
Deposition and transport of linezolid mediated by a synthetic surfactant Synsurf® within a pressurized metered dose inhaler: a Calu-3 model
van Rensburg L, van Zyl JM, Smith J
Drug Design, Development and Therapy 2018, 12:1107-1118
Published Date: 4 May 2018
Efficacy and safety of the CRTh2 antagonist AZD1981 as add-on therapy to inhaled corticosteroids and long-acting β2-agonists in patients with atopic asthma
Bateman ED, O'Brien C, Rugman P, Luke S, Ivanov S, Uddin M
Drug Design, Development and Therapy 2018, 12:1093-1106
Published Date: 4 May 2018
Comparison of the effects of deferasirox, deferoxamine, and combination of deferasirox and deferoxamine on an aplastic anemia mouse model complicated with iron overload
Wu D, Wen X, Liu W, Hu H, Ye B, Zhou Y
Drug Design, Development and Therapy 2018, 12:1081-1091
Published Date: 3 May 2018
Identification of Mycobacterium tuberculosis BioA inhibitors by using structure-based virtual screening
Singh S, Khare G, Bahal RK, Ghosh PC, Tyagi AK
Drug Design, Development and Therapy 2018, 12:1065-1079
Published Date: 1 May 2018
Inactivation of nuclear factor κB by MIP-based drug combinations augments cell death of breast cancer cells
Subramaniam M, Liew SK, In LLA, Awang K, Ahmed N, Nagoor NH
Drug Design, Development and Therapy 2018, 12:1053-1063
Published Date: 1 May 2018
Pharmacokinetic characteristics of telaprevir in healthy Korean male subjects and comparisons with Japanese
Choi Y, Yoon S, Matsumoto K, Ohta Y, Lee S, Yu KS, Jang IJ
Drug Design, Development and Therapy 2018, 12:1045-1051
Published Date: 30 April 2018
Spotlight on isavuconazole in the treatment of invasive aspergillosis and mucormycosis: design, development, and place in therapy
Jenks JD, Salzer HJ, Prattes J, Krause R, Buchheidt D, Hoenigl M
Drug Design, Development and Therapy 2018, 12:1033-1044
Published Date: 30 April 2018
Symmetric dimeric adamantanes for exploring the structure of two viroporins: influenza virus M2 and hepatitis C virus p7
Mandour YM, Breitinger U, Ma C, Wang J, Boeckler FM, Breitinger HG, Zlotos DP
Drug Design, Development and Therapy 2018, 12:1019-1031
Published Date: 30 April 2018
Advances in the drug therapies of acute myeloid leukemia (except acute promyelocytic leukemia)
Lin M, Chen B
Drug Design, Development and Therapy 2018, 12:1009-1017
Published Date: 30 April 2018
4-Amino-2-trifluoromethyl-phenyl retinate inhibits proliferation, invasion, and migration of breast cancer cells by independently regulating CRABP2 and FABP5
Ju J, Wang N, Wang J, Wu F, Ge J, Chen F
Drug Design, Development and Therapy 2018, 12:997-1008
Published Date: 27 April 2018
Clickable prodrugs bearing potent and hydrolytically cleavable nicotinamide phosphoribosyltransferase inhibitors
Sadrerafi K, Mason EO, Lee Jr MW
Drug Design, Development and Therapy 2018, 12:987-995
Published Date: 24 April 2018
The combination of anti-KIR monoclonal antibodies with anti-PD-1/PD-L1 monoclonal antibodies could be a critical breakthrough in overcoming tumor immune escape in NSCLC
He YY, Liu ST, Mattei J, Bunn Jr PA, Zhou CC, Chan D
Drug Design, Development and Therapy 2018, 12:981-986
Published Date: 24 April 2018
A network pharmacology approach to determine the synergetic mechanisms of herb couple for treating rheumatic arthritis
Xu XX, Bi JP, Ping L, Li P, Li F
Drug Design, Development and Therapy 2018, 12:967-979
Published Date: 24 April 2018
Islet protection and amelioration of type 2 diabetes mellitus by treatment with quercetin from the flowers of Edgeworthia gardneri
Zhuang MJ, Qiu HH, Li P, Hu LH, Wang YY, Rao L
Drug Design, Development and Therapy 2018, 12:955-966
Published Date: 23 April 2018
Astragalus polysaccharides protect cardiac stem and progenitor cells by the inhibition of oxidative stress-mediated apoptosis in diabetic hearts
Chen W, Ju J, Yang Y, Wang H, Chen W, Zhao X, Ye H, Zhang Y
Drug Design, Development and Therapy 2018, 12:943-954
Published Date: 20 April 2018
Comparison of tadalafil pharmacokinetics after administration of a new orodispersible film versus a film-coated tablet
Park SI, Heo SH, Kim G, Chang S, Song KH, Kim MG, Jin EH, Kim J, Lee S, Hong JH
Drug Design, Development and Therapy 2018, 12:935-942
Published Date: 20 April 2018
Chitosan–alginate BSA-gel-capsules for local chemotherapy against drug-resistant breast cancer
Shen H, Li F, Wang D, Yang Z, Yao C, Ye Y, Wang X
Drug Design, Development and Therapy 2018, 12:921-934
Published Date: 19 April 2018
Attenuation of everolimus-induced cytotoxicity by a protective autophagic pathway involving ERK activation in renal cell carcinoma cells
Zeng YZ, Tian XF, Wang Q, He WY, Fan J, Gou X
Drug Design, Development and Therapy 2018, 12:911-920
Published Date: 19 April 2018
Theoretical overview of clinical and pharmacological aspects of the use of etelcalcetide in diabetic patients undergoing hemodialysis
Ye J, Deng G, Gao F
Drug Design, Development and Therapy 2018, 12:901-909
Published Date: 19 April 2018
Design, synthesis, and structure–activity relationships of 2-benzylidene-1-indanone derivatives as anti-inflammatory agents for treatment of acute lung injury
Xiao S, Zhang W, Chen H, Fang B, Qiu Y, Chen X, Chen L, Shu S, Zhang Y, Zhao Y, Liu Z, Liang G
Drug Design, Development and Therapy 2018, 12:887-899
Published Date: 19 April 2018
Inhibition of ghrelin o-acyltransferase attenuated lipotoxicity by inducing autophagy via AMPK–mTOR pathway
Zhang S, Mao Y, Fan X
Drug Design, Development and Therapy 2018, 12:873-885
Published Date: 18 April 2018
Lymphoma-targeted treatment using a folic acid-decorated vincristine-loaded drug delivery system
Qiu L, Dong C, Kan X
Drug Design, Development and Therapy 2018, 12:863-872
Published Date: 17 April 2018
Population pharmacokinetics and dosing optimization of cefathiamidine in children with hematologic infection
Zhi LJ, Wang L, Chen XK, Zhai XY, Wen L, Dong L, Jacqz-Aigrain E, Shi ZR, Zhao W
Drug Design, Development and Therapy 2018, 12:855-862
Published Date: 17 April 2018
Ketamine ameliorates oxidative stress-induced apoptosis in experimental traumatic brain injury via the Nrf2 pathway
Liang J, Wu S, Xie W, He H
Drug Design, Development and Therapy 2018, 12:845-853
Published Date: 16 April 2018
Randomized trial of betahistine mesilate tablets as augmentation for oxcarbazepine and carbamazepine in treating vestibular paroxysmia
Xue H, Xiang W, Yu Y, Liu G, Chong Y, Zhou J
Drug Design, Development and Therapy 2018, 12:837-843
Published Date: 12 April 2018
Paeoniflorin improves cardiac function and decreases adverse postinfarction left ventricular remodeling in a rat model of acute myocardial infarction
Chen H, Dong Y, He X, Li J, Wang J
Drug Design, Development and Therapy 2018, 12:823-836
Published Date: 12 April 2018
Pharmacokinetic interactions and tolerability of rosuvastatin and ezetimibe: an open-label, randomized, multiple-dose, crossover study in healthy male volunteers
Kim H, Choi HY, Kim YH, Bae KS, Jung J, Son H, Lim HS
Drug Design, Development and Therapy 2018, 12:815-821
Published Date: 11 April 2018
Transethosomal gels as carriers for the transdermal delivery of colchicine: statistical optimization, characterization, and ex vivo evaluation
Abdulbaqi IM, Darwis Y, Abou Assi R, Abdul Karim Khan N
Drug Design, Development and Therapy 2018, 12:795-813
Published Date: 9 April 2018
Evaluation of drug interactions between fimasartan and rosuvastatin after single and multiple doses in healthy Caucasians
Lee J, Rhee SJ, Lee S, Yu KS
Drug Design, Development and Therapy 2018, 12:787-794
Published Date: 6 April 2018
Aldoxorubicin: a tumor-targeted doxorubicin conjugate for relapsed or refractory soft tissue sarcomas
Gong J, Yan J, Forscher C, Hendifar A
Drug Design, Development and Therapy 2018, 12:777-786
Published Date: 6 April 2018
Upregulation of vascular endothelial growth factor receptor-1 contributes to sevoflurane preconditioning–mediated cardioprotection
Qian B, Yang Y, Yao Y, Liao Y, Lin Y
Drug Design, Development and Therapy 2018, 12:769-776
Published Date: 6 April 2018
Reevaluation of the post-marketing safety of Shuxuening injection based on real-world and evidence-based evaluations
Wang C, Shi QP, Ding F, Jiang XD, Tang W, Yu ML, Zhu JH
Drug Design, Development and Therapy 2018, 12:757-767
Published Date: 5 April 2018
Cell-penetrating peptide conjugates of gambogic acid enhance the antitumor effect on human bladder cancer EJ cells through ROS-mediated apoptosis
Lyu L, Huang LQ, Huang T, Xiang W, Yuan JD, Zhang CH
Drug Design, Development and Therapy 2018, 12:743-756
Published Date: 5 April 2018
The efficacy and safety of Ginkgo biloba extract as an adjuvant in type 2 diabetes mellitus patients ineffectively managed with metformin: a double-blind, randomized, placebo-controlled trial
Aziz TA, Hussain SA, Mahwi TO, Ahmed ZA, Rahman HS, Rasedee A
Drug Design, Development and Therapy 2018, 12:735-742
Published Date: 5 April 2018
Chrysin suppresses proliferation, migration, and invasion in glioblastoma cell lines via mediating the ERK/Nrf2 signaling pathway
Wang J, Wang HD, Sun KJ, Wang XL, Pan H, Zhu JH, Ji XJ, Li X
Drug Design, Development and Therapy 2018, 12:721-733
Published Date: 3 April 2018
Preparation and in vitro/in vivo evaluation of PLGA microspheres containing norquetiapine for long-acting injection
Park CW, Lee HJ, Oh DW, Kang JH, Han CS, Kim DW
Drug Design, Development and Therapy 2018, 12:711-719
Published Date: 5 April 2018
The effectiveness of long-term course of Sterimar Mn nasal spray for treatment of the recurrence rates of acute allergic rhinitis in patients with chronic allergic rhinitis
Grasso M, de Vincentiis M, Agolli G, Cilurzo F, Grasso R
Drug Design, Development and Therapy 2018, 12:705-709
Published Date: 3 April 2018
Hot-water extract of the branches of Hovenia dulcis Thunb. (Rhamnaceae) ameliorates low-fiber diet-induced constipation in rats
Choi CY, Cho SS, Yoon IS
Drug Design, Development and Therapy 2018, 12:695-703
Published Date: 3 April 2018
Organic mononitrites of 1,2-propanediol act as an effective NO-releasing vasodilator in pulmonary hypertension and exhibit no cross-tolerance with nitroglycerin in anesthetized pigs
Nilsson KF, Goździk W, Frostell C, Zieliński S, Zielińska M, Ratajczak K, Skrzypczak P, Rodziewicz S, Albert J, Gustafsson LE
Drug Design, Development and Therapy 2018, 12:685-694
Published Date: 29 March 2018
Anticancer activity of the intraperitoneal-delivered DFP-10825, the cationic liposome-conjugated RNAi molecule targeting thymidylate synthase, on peritoneal disseminated ovarian cancer xenograft model
Iizuka K, Jin C, Eshima K, Hong MH, Eshima K, Fukushima M
Drug Design, Development and Therapy 2018, 12:673-683
Published Date: 29 March 2018
The apoptotic effects of Brucea javanica fruit extract against HT29 cells associated with p53 upregulation and inhibition of NF-κB translocation
Bagheri E, Hajiaghaalipour F, Nyamathulla S, Salehen N
Drug Design, Development and Therapy 2018, 12:657-671
Published Date: 29 March 2018
Peptides derived from Plasmodium falciparum leucine-rich repeat 1 bind to serine/threonine phosphatase type 1 and inhibit parasite growth in vitro [Corrigendum]
Pierrot C, Zhang X, Zanghi G, Fréville A, Rebollo A, Khalife J
Drug Design, Development and Therapy 2018, 12:655-656
Published Date: 29 March 2018
Comparison of oral dexmedetomidine and midazolam for premedication and emergence delirium in children after dental procedures under general anesthesia: a retrospective study
Keles S, Kocaturk O
Drug Design, Development and Therapy 2018, 12:647-653
Published Date: 28 March 2018
The role of propranolol as a radiosensitizer in gastric cancer treatment
Liao XH, Chaudhary P, Qiu G, Che XM, Fan L
Drug Design, Development and Therapy 2018, 12:639-645
Published Date: 28 March 2018
Sevoflurane post-conditioning attenuates traumatic brain injury-induced neuronal apoptosis by promoting autophagy via the PI3K/AKT signaling pathway
He H, Liu W, Zhou Y, Liu Y, Weng P, Li Y, Fu H
Drug Design, Development and Therapy 2018, 12:629-638
Published Date: 23 March 2018
Benralizumab in the treatment of severe asthma: design, development and potential place in therapy
Pelaia C, Vatrella A, Bruni A, Terracciano R, Pelaia G
Drug Design, Development and Therapy 2018, 12:619-628
Published Date: 21 March 2018
Rucaparib: a novel PARP inhibitor for BRCA advanced ovarian cancer
Colombo I, Lheureux S, Oza AM
Drug Design, Development and Therapy 2018, 12:605-617
Published Date: 21 March 2018
Tendinopathy: injury, repair, and current exploration
Lipman K, Wang CC, Ting K, Soo C, Zheng Z
Drug Design, Development and Therapy 2018, 12:591-603
Published Date: 20 March 2018
The hydroxypropyl–β-cyclodextrin complexation of toltrazuril for enhancing bioavailability
Zhang L, Liu MX, Lu CC, Ren DD, Fan GQ, Liu C, Liu MJ, Shu G, Peng GN, Yuan ZX, Zhong ZJ, Zhang W, Fu HL
Drug Design, Development and Therapy 2018, 12:583-589
Published Date: 19 March 2018
Bioequivalence of a biosimilar enoxaparin sodium to Clexane® after single 100 mg subcutaneous dose: results of a randomized, double-blind, crossover study in healthy volunteers
Martínez González J, Monreal M, Ayani Almagia I, Llaudó Garín J, Ochoa Díaz de Monasterioguren L, Gutierro Adúriz I
Drug Design, Development and Therapy 2018, 12:575-582
Published Date: 19 March 2018
Vitexin protects dopaminergic neurons in MPTP-induced Parkinson’s disease through PI3K/Akt signaling pathway
Hu M, Li F, Wang W
Drug Design, Development and Therapy 2018, 12:565-573
Published Date: 16 March 2018
Effect of tocotrienol from Bixa orellana (annatto) on bone microstructure, calcium content, and biomechanical strength in a model of male osteoporosis induced by buserelin
Mohamad NV, Ima-Nirwana S, Chin KY
Drug Design, Development and Therapy 2018, 12:555-564
Published Date: 16 March 2018
Pharmacokinetic and bioequivalence study of a telmisartan/S-amlodipine fixed-dose combination (CKD-828) formulation and coadministered telmisartan and S-amlodipine in healthy subjects
Kang WY, Seong SJ, Ohk B, Gwon M, Kim BK, La S, Kim HJ, Cho S, Yoon Y, Yang DH, Lee HW
Drug Design, Development and Therapy 2018, 12:545-553
Published Date: 14 March 2018
Enhanced gastric therapeutic effects of Brucea javanica oil and its gastroretentive drug delivery system compared to commercial products in pharmacokinetics study
Zhang Y, Zhang L, Zhang Q, Zhang X, Zhang T, Wang B
Drug Design, Development and Therapy 2018, 12:535-544
Published Date: 13 March 2018
Involvement of NF-κB and HSP70 signaling pathways in the apoptosis of MDA-MB-231 cells induced by a prenylated xanthone compound, α-mangostin, from Cratoxylum arborescens [Corrigendum] [Retraction]
Ibrahim MY, Mohd Hashim N, Mohan S, Mohd Ali H, Abdelwahab S, Kamalidehghan B, Ghaderian M, Dehghan F, Salim LZ, Karimian H, Yahayu M, Ee Cheng Lian G, Abdulla M, Farjam AS
Drug Design, Development and Therapy 2018, 12:533-534
Published Date: 13 March 2018
Can dexmedetomidine reduce atrial fibrillation after cardiac surgery? A systematic review and meta-analysis
Zhu ZP, Zhou HM, Ni YJ, Wu C, Zhang CJ, Ling XY
Drug Design, Development and Therapy 2018, 12:521-531
Published Date: 12 March 2018
Inhibitory effect of celecoxib on agomelatine metabolism in vitro and in vivo
He JY, Fang P, Zheng X, Wang CC, Liu TH, Zhang BW, Wen J, Xu RA
Drug Design, Development and Therapy 2018, 12:513-519
Published Date: 9 March 2018
Development of small bisquaternary cholinesterase inhibitors as drugs for pre-treatment of nerve agent poisonings
Kuca K, Karasova JZ, Soukup O, Kassa J, Novotna E, Sepsova V, Horova A, Pejchal J, Hrabinova M, Vodakova E, Jun D, Nepovimova E, Valis M, Musilek K
Drug Design, Development and Therapy 2018, 12:505-512
Published Date: 9 March 2018
Preclinical pharmacokinetics, interspecies scaling, and pharmacokinetics of a Phase I clinical trial of TTAC-0001, a fully human monoclonal antibody against vascular endothelial growth factor 2
Lee WS, Shim SR, Lee SY, Yoo JS, Cho SK
Drug Design, Development and Therapy 2018, 12:495-504
Published Date: 8 March 2018
Development of controlled release silicone adhesive–based mupirocin patch demonstrates antibacterial activity on live rat skin against Staphylococcus aureus
David SR, Malek N, Mahadi AH, Chakravarthi S, Rajabalaya R
Drug Design, Development and Therapy 2018, 12:481-494
Published Date: 8 March 2018
Combination therapy versus gemcitabine monotherapy in the treatment of elderly pancreatic cancer: a meta-analysis of randomized controlled trials
Jin JM, Teng CB, Li T
Drug Design, Development and Therapy 2018, 12:475-480
Published Date: 7 March 2018
Synovial tissue quantitative proteomics analysis reveals paeoniflorin decreases LIFR and ASPN proteins in experimental rheumatoid arthritis
Yang S, Xing ZH, Liu T, Zhou J, Liang QH, Tang T, Cui HJ, Peng WJ, Xiong XG, Wang Y
Drug Design, Development and Therapy 2018, 12:463-473
Published Date: 6 March 2018
Combined application of tenuigenin and β-asarone improved the efficacy of memantine in treating moderate-to-severe Alzheimer’s disease
Chang W, Teng J
Drug Design, Development and Therapy 2018, 12:455-462
Published Date: 5 March 2018
Intra-articular platelet-rich plasma versus hyaluronic acid in the treatment of knee osteoarthritis: a meta-analysis
Zhang HF, Wang CG, Li H, Huang YT, Li ZJ
Drug Design, Development and Therapy 2018, 12:445-453
Published Date: 5 March 2018
Efficacy of atorvastatin on the prevention of contrast-induced acute kidney injury: a meta-analysis
Liu L, Liu Y, Wu M, Sun Y, Ma F
Drug Design, Development and Therapy 2018, 12:437-444
Published Date: 2 March 2018
Bioequivalence of HTX-019 (aprepitant IV) and fosaprepitant in healthy subjects: a Phase I, open-label, randomized, two-way crossover evaluation
Ottoboni T, Keller MR, Cravets M, Clendeninn N, Quart B
Drug Design, Development and Therapy 2018, 12:429-435
Published Date: 1 March 2018
Risk factors for calcineurin inhibitor nephrotoxicity after renal transplantation: a systematic review and meta-analysis
Xia T, Zhu S, Wen Y, Gao S, Li M, Tao X, Zhang F, Chen W
Drug Design, Development and Therapy 2018, 12:417-428
Published Date: 28 February 2018
Magnesium: does it reduce ischemia/reperfusion injury in an adnexal torsion rat model?
Celik Kavak E, Gulcu Bulmus F, Bulmus O, Kavak SB, Kocaman N
Drug Design, Development and Therapy 2018, 12:409-415
Published Date: 28 February 2018
Integration of microRNA–mRNA profiles and pathway analysis of plant isoquinoline alkaloid berberine in SGC-7901 gastric cancers cells
Yang YH, Zhang N, Li KD, Chen J, Qiu L, Zhang JF
Drug Design, Development and Therapy 2018, 12:393-408
Published Date: 28 February 2018
The role of maintenance therapy in the treatment of elderly non-small-cell lung cancer patients: a meta-analysis of randomized controlled trials [Corrigendum]
Zhang L, Gao S, He J
Drug Design, Development and Therapy 2018, 12:391-392
Published Date: 27 February 2018
RETRACTED ARTICLE: A novel ocular delivery of brinzolamide based on gellan gum: in vitro and in vivo evaluation
Sun J, Zhou Z
Drug Design, Development and Therapy 2018, 12:383-389
Published Date: 23 February 2018
Fasudil inhibits proliferation and migration of Hep-2 laryngeal carcinoma cells
Zhang X, Wu N
Drug Design, Development and Therapy 2018, 12:373-381
Published Date: 23 February 2018
Therapeutic potential of bimatoprost for the treatment of eyebrow hypotrichosis
Chanasumon N, Sriphojanart T, Suchonwanit P
Drug Design, Development and Therapy 2018, 12:365-372
Published Date: 22 February 2018
Formulation design and development of matrix diffusion controlled transdermal drug delivery of glimepiride
Akram MR, Ahmad M, Abrar A, Sarfraz RM, Mahmood A
Drug Design, Development and Therapy 2018, 12:349-364
Published Date: 21 February 2018
Risk of severe hematologic toxicities in cancer patients treated with PARP inhibitors: results of monotherapy and combination therapy trials
Alecu I, Milenkova T, Turner SR
Drug Design, Development and Therapy 2018, 12:347-348
Published Date: 21 February 2018
Short-term efficacy of intravitreal conbercept in treatment-naive patients with polypoidal choroidal vasculopathy
Peng Y, Zhang X, Li M, Liu B, Mi L, Zuo C, Wen F
Drug Design, Development and Therapy 2018, 12:339-345
Published Date: 19 February 2018
Pharmacokinetics and tolerability of eletriptan hydrobromide in healthy Korean subjects
Kim YK, Shin KH, Alderman J, Yu KS, Jang IJ, Lee S
Drug Design, Development and Therapy 2018, 12:331-337
Published Date: 19 February 2018
Abemaciclib: a CDK4/6 inhibitor for the treatment of HR+/HER2– advanced breast cancer
Corona SP, Generali D
Drug Design, Development and Therapy 2018, 12:321-330
Published Date: 16 February 2018
Review of deutetrabenazine: a novel treatment for chorea associated with Huntington's disease
Dean M, Sung VW
Drug Design, Development and Therapy 2018, 12:313-319
Published Date: 15 February 2018
Berberine nanoparticles with enhanced in vitro bioavailability: characterization and antimicrobial activity
Sahibzada MUK, Sadiq A, Faidah HS, Khurram M, Amin MU, Haseeb A, Kakar M
Drug Design, Development and Therapy 2018, 12:303-312
Published Date: 14 February 2018
Comparison of the long-term efficacy and safety of generic tacrolimus, Tacrobell, with Prograf in liver transplant recipients
Choi HJ, Kim DG, Kwak BJ, Han JH, Hong TH, You YK
Drug Design, Development and Therapy 2018, 12:295-301
Published Date: 13 February 2018
Asthma and poly(ADP-ribose) polymerase inhibition: a new therapeutic approach
Zaffini R, Gotte G, Menegazzi M
Drug Design, Development and Therapy 2018, 12:281-293
Published Date: 12 February 2018
Reference ranges for antiepileptic drugs revisited: a practical approach to establish national guidelines
Reimers A, Berg JA, Burns ML, Brodtkorb E, Johannessen SI, Johannessen Landmark C
Drug Design, Development and Therapy 2018, 12:271-280
Published Date: 8 February 2018
Experimental and molecular modeling approach to optimize suitable polymers for fabrication of stable fluticasone nanoparticles with enhanced dissolution and antimicrobial activity
Ahmed S, Govender T, Khan I, ur Rehman N, Ali W, Shah SMH, Khan S, Hussain Z, Ullah R, Alsaid MS
Drug Design, Development and Therapy 2018, 12:255-269
Published Date: 5 February 2018
Clinical potential of mechlorethamine gel for the topical treatment of mycosis fungoides-type cutaneous T-cell lymphoma: a review on current efficacy and safety data
Liner K, Brown C, McGirt LY
Drug Design, Development and Therapy 2018, 12:241-254
Published Date: 31 January 2018
Dysregulation of Neuregulin-1/ErbB signaling in the hippocampus of rats after administration of doxorubicin
Liao D, Guo Y, Xiang D, Dang R, Xu P, Cai H, Cao L, Jiang P
Drug Design, Development and Therapy 2018, 12:231-239
Published Date: 30 January 2018
The influence of prebiotic or probiotic supplementation on antibody titers after influenza vaccination: a systematic review and meta-analysis of randomized controlled trials
Yeh TL, Shih PC, Liu SJ, Lin CH, Liu JM, Lei WT, Lin CY
Drug Design, Development and Therapy 2018, 12:217-230
Published Date: 25 January 2018
Durvalumab: an investigational anti-PD-L1 monoclonal antibody for the treatment of urothelial carcinoma
Faiena I, Cummings AL, Crosetti AM, Pantuck AJ, Chamie K, Drakaki A
Drug Design, Development and Therapy 2018, 12:209-215
Published Date: 23 January 2018
Bispecific antibodies: design, therapy, perspectives
Sedykh SE, Prinz VV, Buneva VN, Nevinsky GA
Drug Design, Development and Therapy 2018, 12:195-208
Published Date: 22 January 2018
Anticonvulsant and reproductive toxicological studies of the imidazole-based histamine H3R antagonist 2-18 in mice
Bastaki SM, Abdulrazzaq YM, Shafiullah M, Więcek M, Kieć-Kononowicz K, Sadek B
Drug Design, Development and Therapy 2018, 12:179-194
Published Date: 19 January 2018
Involvement of microRNA-146a in diabetic peripheral neuropathy through the regulation of inflammation
Feng Y, Chen L, Luo Q, Wu M, Chen Y, Shi X
Drug Design, Development and Therapy 2018, 12:171-177
Published Date: 17 January 2018
Diminishing the side effect of mitomycin C by using pH-sensitive liposomes: in vitro characterization and in vivo pharmacokinetics
Fang YP, Hu PY, Huang YB
Drug Design, Development and Therapy 2018, 12:159-169
Published Date: 15 January 2018
Biological activity, quantitative structure–activity relationship analysis, and molecular docking of xanthone derivatives as anticancer drugs
Miladiyah I, Jumina J, Haryana SM, Mustofa M
Drug Design, Development and Therapy 2018, 12:149-158
Published Date: 15 January 2018
Ipriflavone promotes proliferation and osteogenic differentiation of periodontal ligament cells by activating GPR30/PI3K/AKT signaling pathway
Han Y, Wang X, Ma D, Wu X, Yang P, Zhang J
Drug Design, Development and Therapy 2018, 12:137-148
Published Date: 11 January 2018
Natural products, an important resource for discovery of multitarget drugs and functional food for regulation of hepatic glucose metabolism
Li J, Yu H, Wang S, Wang W, Chen Q, Ma Y, Zhang Y, Wang T
Drug Design, Development and Therapy 2018, 12:121-135
Published Date: 10 January 2018
Efficacy and side effects of intravenous theophylline in acute asthma: a systematic review and meta-analysis
Mahemuti G, Zhang H, Li J, Tieliwaerdi N, Ren L
Drug Design, Development and Therapy 2018, 12:99-120
Published Date: 10 January 2018
Renal-protective effect of thalidomide in streptozotocin-induced diabetic rats through anti-inflammatory pathway
Zhang H, Yang Y, Wang Y, Wang B, Li R
Drug Design, Development and Therapy 2018, 12:89-98
Published Date: 9 January 2018
Peptides derived from Plasmodium falciparum leucine-rich repeat 1 bind to serine/threonine phosphatase type 1 and inhibit parasite growth in vitro
Pierrot C, Zhang X, Zanghi G, Fréville A, Rebollo A, Khalife J
Drug Design, Development and Therapy 2018, 12:85-88
Published Date: 9 January 2018
Sinomenine reduces neuronal cell apoptosis in mice after traumatic brain injury via its effect on mitochondrial pathway
Fu C, Wang Q, Zhai X, Gao J
Drug Design, Development and Therapy 2018, 12:77-84
Published Date: 5 January 2018
Quantitative assessment of the effects of chitosan intervention on blood pressure control
Huang H, Zou Y, Chi H
Drug Design, Development and Therapy 2018, 12:67-75
Published Date: 28 December 2017
The oral bioavailability, excretion and cytochrome P450 inhibition properties of epiberberine: an in vivo and in vitro evaluation
Chen N, Yang X, Guo C, Bi X, Chen J, Chen H, Li H, Lin H, Zhang Y
Drug Design, Development and Therapy 2018, 12:57-65
Published Date: 28 December 2017
Portulaca oleracea L. alleviates liver injury in streptozotocin-induced diabetic mice
Zheng G, Mo F, Ling C, Peng H, Gu W, Li M, Chen Z
Drug Design, Development and Therapy 2018, 12:47-55
Published Date: 28 December 2017
Clinical features of hypophosphatemic osteomalacia induced by long-term low-dose adefovir dipivoxil
Zhu S, Yang YH, Gao RW, Li R, Zou YZ, Feng L, Zhang B
Drug Design, Development and Therapy 2018, 12:41-45
Published Date: 27 December 2017
Leishmaniasis in humans: drug or vaccine therapy?
Ghorbani M, Farhoudi R
Drug Design, Development and Therapy 2018, 12:25-40
Published Date: 22 December 2017
Intra-articular collagenase injection increases range of motion in a rat knee flexion contracture model
Wong K, Trudel G, Laneuville O
Drug Design, Development and Therapy 2018, 12:15-24
Published Date: 21 December 2017
HX575: established biosimilarity in the treatment of renal anemia and 10 years of clinical experience
Dellanna F, Goldsmith D, Krendyukov A, Seidl A, Höbel N, Combe C
Drug Design, Development and Therapy 2018, 12:9-14
Published Date: 18 December 2017
RETRACTED ARTICLE: Development of a nanoliposomal formulation of erlotinib for lung cancer and in vitro/in vivo antitumoral evaluation
Zhou X, Tao H, Shi KH
Drug Design, Development and Therapy 2018, 12:1-8
Published Date: 18 December 2017