Back to Journals » Drug Design, Development and Therapy » Volume 12 » default

Drug Design, Development and Therapy


Archive: Volume 12, 2018

Current research for a vaccine against Lassa hemorrhagic fever virus

Warner BM, Safronetz D, Stein DR

Drug Design, Development and Therapy 2018, 12:2519-2527

Published Date: 14 August 2018

Baicalin provides neuroprotection in traumatic brain injury mice model through Akt/Nrf2 pathway

Fang J, Wang H, Zhou J, Dai W, Zhu Y, Zhou Y, Wang X, Zhou M

Drug Design, Development and Therapy 2018, 12:2497-2508

Published Date: 10 August 2018

Milnacipran poorly modulates pain in patients suffering from fibromyalgia: a randomized double-blind controlled study

Pickering G, Macian N, Delage N, Picard P, Cardot JM, Sickout-Arondo S, Giron F, Dualé C, Pereira B, Marcaillou F

Drug Design, Development and Therapy 2018, 12:2485-2496

Published Date: 10 August 2018

Preclinical safety evaluation of hepatic arterial infusion of oncolytic poxvirus

Cho E, Ryu EJ, Jiang F, Jeon UB, Cho M, Kim CH, Kim M, Kim ND, Hwang TH

Drug Design, Development and Therapy 2018, 12:2467-2474

Published Date: 8 August 2018

Systematic review and meta-analysis of the benefit of celecoxib in treating advanced non-small-cell lung cancer

Yi L, Zhang W, Zhang H, Shen J, Zou J, Luo P, Zhang J

Drug Design, Development and Therapy 2018, 12:2455-2466

Published Date: 7 August 2018

Antihyperlipidemic studies of newly synthesized phenolic derivatives: in silico and in vivo approaches

Aqeel MT, ur-Rahman N, Khan A, Ashraf Z, Latif M, Rafique H, Rasheed U

Drug Design, Development and Therapy 2018, 12:2443-2453

Published Date: 9 August 2018

Monitoring antiangiogenesis of bevacizumab in zebrafish

Zhang J, Gao BL, Zhang WC, Qian ZJ, Xiang Y

Drug Design, Development and Therapy 2018, 12:2423-2430

Published Date: 6 August 2018

Sinomenine inhibits the growth of melanoma by enhancement of autophagy via PI3K/AKT/mTOR inhibition

Sun Z, Zheng L, Liu X, Xing W, Liu X

Drug Design, Development and Therapy 2018, 12:2413-2421

Published Date: 6 August 2018

Zafirlukast in combination with pseudohypericin attenuates spinal cord injury and motor function in experimental mice

Chen XG, Hua F, Wang SG, Xu YY, Yue HT, Sun J

Drug Design, Development and Therapy 2018, 12:2389-2402

Published Date: 1 August 2018

Comparison of biosimilar filgrastim with a reference product: pharmacokinetics, pharmacodynamics, and safety profiles in healthy volunteers

Choi C, Yoo BW, Kim CO, Hong T, Jin BH, Seo KS, Jang JY, Park MS

Drug Design, Development and Therapy 2018, 12:2381-2387

Published Date: 1 August 2018

Pharmacological mechanism of roflumilast in the treatment of asthma–COPD overlap

Zhang X, Chen Y, Fan L, Ye J, Fan J, Xu X, You D, Liu S, Chen X, Luo P

Drug Design, Development and Therapy 2018, 12:2371-2379

Published Date: 1 August 2018

Doxorubicin-conjugated dexamethasone induced MCF-7 apoptosis without entering the nucleus and able to overcome MDR-1-induced resistance

Chaikomon K, Chattong S, Chaiya T, Tiwawech D, Sritana-Anant Y, Sereemaspun A, Manotham K

Drug Design, Development and Therapy 2018, 12:2361-2369

Published Date: 1 August 2018

Discovery of nonnucleoside inhibitors of polymerase from infectious pancreatic necrosis virus (IPNV)

Bello-Pérez M, Falco A, Galiano V, Coll J, Perez L, Encinar JA

Drug Design, Development and Therapy 2018, 12:2337-2359

Published Date: 30 July 2018

Role of janus kinase inhibitors in the treatment of alopecia areata

Triyangkulsri K, Suchonwanit P

Drug Design, Development and Therapy 2018, 12:2323-2335

Published Date: 27 July 2018

Care pathways and treatment patterns for patients with heart failure in China: results from a cross-sectional survey

Jackson JDS, Cotton SE, Bruce Wirta S, Proenca CC, Zhang M, Lahoz R, Balas B, Calado FJ

Drug Design, Development and Therapy 2018, 12:2311-2321

Published Date: 26 July 2018

Pharmacokinetic interaction between fimasartan and atorvastatin in healthy male volunteers

Choi Y, Lee S, Jang IJ, Yu KS

Drug Design, Development and Therapy 2018, 12:2301-2309

Published Date: 24 July 2018

Effects of the traditional Chinese medicine baicalein on the viability of random pattern skin flaps in rats

Lin R, Lin J, Li S, Ding J, Wu H, Xiang G, Li S, Huang Y, Lin D, Gao W, Kong J, Xu H, Zhou K

Drug Design, Development and Therapy 2018, 12:2267-2276

Published Date: 23 July 2018

The effects of bisphosphonates on osteoporotic patients after lumbar fusion: a meta-analysis

Liu WB, Zhao WT, Shen P, Zhang FJ

Drug Design, Development and Therapy 2018, 12:2233-2240

Published Date: 17 July 2018

Radiosensitivity enhancement by combined treatment of nimotuzumab and celecoxib on nasopharyngeal carcinoma cells

Huang JF, Yuan XP, Pang QF, Zhang HW, Yu JH, Yang B, Zhou LY, Zhang FZ, Liu FJ

Drug Design, Development and Therapy 2018, 12:2223-2231

Published Date: 16 July 2018

Emodin mitigates podocytes apoptosis induced by endoplasmic reticulum stress through the inhibition of the PERK pathway in diabetic nephropathy

Tian N, Gao Y, Wang X, Wu X, Zou D, Zhu Z, Han ZJ, Wang T, Shi Y

Drug Design, Development and Therapy 2018, 12:2195-2211

Published Date: 13 July 2018

Antifungal activity of Cardiospermum halicacabum L. (Sapindaceae) against Trichophyton rubrum occurs through molecular interaction with fungal Hsp90

Gaziano R, Campione E, Iacovelli F, Marino D, Pica F, Di Francesco P, Aquaro S, Menichini F, Falconi M, Bianchi L

Drug Design, Development and Therapy 2018, 12:2185-2193

Published Date: 12 July 2018

A case report of toxic epidermal necrolysis associated with AZD-9291

Wang J, Cheng XY, Lu Y, Zhou BR

Drug Design, Development and Therapy 2018, 12:2163-2167

Published Date: 11 July 2018

Effect of green tea catechins on the pharmacokinetics of digoxin in humans

Kim TE, Shin KH, Park JE, Kim MG, Yun YM, Choi DH, Kwon KJ, Lee J

Drug Design, Development and Therapy 2018, 12:2139-2147

Published Date: 10 July 2018

Development of a tin oxide carrier with mesoporous structure for improving the dissolution rate and oral relative bioavailability of fenofibrate

Bai A, Wu C, Liu X, Lv H, Xu X, Cao Y, Shang W, Hu L, Liu Y

Drug Design, Development and Therapy 2018, 12:2129-2138

Published Date: 10 July 2018

Self-nanomicellizing solid dispersion of edaravone: part II: in vivo assessment of efficacy against behavior deficits and safety in Alzheimer’s disease model

Parikh A, Kathawala K, Li JT, Chen C, Shan Z, Cao X, Wang YJ, Garg S, Zhou XF

Drug Design, Development and Therapy 2018, 12:2111-2128

Published Date: 9 July 2018

Design and development of ICCA as a dual inhibitor of GPIIb/IIIa and P-selectin receptors

Chen H, Lu A, Zhang X, Gui L, Wang YN, Wu J, Feng H, Peng S, Zhao M

Drug Design, Development and Therapy 2018, 12:2097-2110

Published Date: 9 July 2018

Safety and efficacy of durvalumab (MEDI4736) in various solid tumors

Yang H, Shen K, Zhu C, Li Q, Zhao Y, Ma X

Drug Design, Development and Therapy 2018, 12:2085-2096

Published Date: 6 July 2018

Self-nanomicellizing solid dispersion of edaravone: part I – oral bioavailability improvement

Parikh A, Kathawala K, Tan CC, Garg S, Zhou XF

Drug Design, Development and Therapy 2018, 12:2051-2069

Published Date: 5 July 2018

Antiangiogenic cytokines as potential new therapeutic targets for resveratrol in diabetic retinopathy

Popescu M, Bogdan C, Pintea A, Rugină D, Ionescu C

Drug Design, Development and Therapy 2018, 12:1985-1996

Published Date: 3 July 2018

Pharmacokinetics of placental protein 13 after intravenous and subcutaneous administration in rabbits

Drobnjak T, Meiri H, Mandalà M, Huppertz B, Gizurarson S

Drug Design, Development and Therapy 2018, 12:1977-1983

Published Date: 3 July 2018

Gemcitabine hydrochloride microspheres used for intravesical treatment of superficial bladder cancer: a comprehensive in vitro/ex vivo/in vivo evaluation

Karavana SY, Ay Şenyiğit Z, Çalışkan Ç, Sevin G, İlem Özdemir D, Erzurumlu Y, Şen S, Baloğlu E

Drug Design, Development and Therapy 2018, 12:1959-1975

Published Date: 2 July 2018

Daptomycin: a comparison of two intravenous formulations

Frankenfeld C, Mittal S, Melendez Y, Mendez-Vigo L, Lamp KC, Keller KN, Bertolami SR

Drug Design, Development and Therapy 2018, 12:1953-1958

Published Date: 29 June 2018

Mechanism of Yanghe Pingchuan granules treatment for airway remodeling in asthma

Pan LY, Han YQ, Wang YZ, Chen QQ, Wu Y, Sun Y

Drug Design, Development and Therapy 2018, 12:1941-1951

Published Date: 27 June 2018

Electroporation-enhanced transdermal diclofenac sodium delivery into the knee joint in a rat model of acute arthritis

Hartmann P, Butt E, Fehér Á, Szilágyi ÁL, Jász KD, Balázs B, Bakonyi M, Berkó S, Erős G, Boros M, Horváth G, Varga E, Csányi E

Drug Design, Development and Therapy 2018, 12:1917-1930

Published Date: 27 June 2018

The mechanism of botulinum A on Raynaud syndrome

Zhou Y, Liu Y, Hao Y, Feng Y, Pan L, Liu W, Li B, Xiao L, Jin L, Nie Z

Drug Design, Development and Therapy 2018, 12:1905-1915

Published Date: 26 June 2018

Modes of cell death induced by tetrahydroisoquinoline-based analogs in MDA-MB-231 breast and A549 lung cancer cell lines

Nel M, Joubert AM, Dohle W, Potter BVL, Theron AE

Drug Design, Development and Therapy 2018, 12:1881-1904

Published Date: 25 June 2018

Additive effect of oral LDD175 to tamsulosin and finasteride in a benign prostate hyperplasia rat model

Choi BR, Kim HK, Soni KK, Karna KK, Lee SW, So I, Park JK

Drug Design, Development and Therapy 2018, 12:1855-1863

Published Date: 22 June 2018

Salidroside ameliorates autophagy and activation of hepatic stellate cells in mice via NF-κB and TGF-β1/Smad3 pathways

Feng J, Chen K, Xia Y, Wu L, Li J, Li S, Wang W, Lu X, Liu T, Guo C

Drug Design, Development and Therapy 2018, 12:1837-1853

Published Date: 22 June 2018

Sevoflurane anaesthesia during pregnancy in mice induces hearing impairment in the offspring

Shen X, Xiao Y, Li W, Chen K, Yu H

Drug Design, Development and Therapy 2018, 12:1827-1836

Published Date: 22 June 2018

Use of levosimendan in the treatment of cerebral vascular vasospasm: a case study

Onichimowski D, Nosek K, Goraj R, Jalali R, Wińska A, Pawlos A, Tuyakov B

Drug Design, Development and Therapy 2018, 12:1777-1783

Published Date: 20 June 2018

Clinical efficacy of nab-paclitaxel in patients with metastatic pancreatic cancer

De Luca R, Blasi L, Alù M, Gristina V, Cicero G

Drug Design, Development and Therapy 2018, 12:1769-1775

Published Date: 19 June 2018

Linezolid: a review of its properties, function, and use in critical care

Hashemian SMR, Farhadi T, Ganjparvar M

Drug Design, Development and Therapy 2018, 12:1759-1767

Published Date: 18 June 2018

Lights and shadows of NSAIDs in bone healing: the role of prostaglandins in bone metabolism

Lisowska B, Kosson D, Domaracka K

Drug Design, Development and Therapy 2018, 12:1753-1758

Published Date: 18 June 2018

Annatto-derived tocotrienol stimulates osteogenic activity in preosteoblastic MC3T3-E1 cells: a temporal sequential study

Wan Hasan WN, Abd Ghafar N, Chin KY, Ima-Nirwana S

Drug Design, Development and Therapy 2018, 12:1715-1726

Published Date: 13 June 2018

Effect of food on the pharmacokinetic characteristics of a single oral dose of LCB01-0371, a novel oxazolidinone antibiotic

Sunwoo J, Kim YK, Choi Y, Yu KS, Nam H, Cho YL, Yoon S, Chung JY

Drug Design, Development and Therapy 2018, 12:1707-1714

Published Date: 11 June 2018

Chloroquine and hydroxychloroquine are associated with reduced cardiovascular risk: a systematic review and meta-analysis

Liu D, Li X, Zhang Y, Kwong JSW, Li L, Zhang Y, Xu C, Li Q, Sun X, Tian H, Li S

Drug Design, Development and Therapy 2018, 12:1685-1695

Published Date: 11 June 2018

Burden of heart failure on caregivers in China: results from a cross-sectional survey

Jackson JDS, Cotton SE, Bruce Wirta S, Proenca CC, Zhang M, Lahoz R, Calado FJ

Drug Design, Development and Therapy 2018, 12:1669-1678

Published Date: 8 June 2018

Burden of heart failure on patients from China: results from a cross-sectional survey

Jackson JDS, Cotton SE, Bruce Wirta S, Proenca CC, Zhang M, Lahoz R, Calado FJ

Drug Design, Development and Therapy 2018, 12:1659-1668

Published Date: 8 June 2018

AMPK/AS160 mediates tiliroside derivatives-stimulated GLUT4 translocation in muscle cells

Zhang C, Jiang Y, Liu J, Jin M, Qin N, Chen Y, Niu W, Duan H

Drug Design, Development and Therapy 2018, 12:1581-1587

Published Date: 1 June 2018

Optimization of a combined wet milling process in order to produce poly(vinyl alcohol) stabilized nanosuspension

Bartos C, Jójárt-Laczkovich O, Katona G, Budai-Szűcs M, Ambrus R, Bocsik A, Gróf I, Deli MA, Szabó-Révész P

Drug Design, Development and Therapy 2018, 12:1567-1580

Published Date: 31 May 2018

2-Amino-1,3,4-thiadiazole as a potential scaffold for promising antimicrobial agents

Serban G, Stanasel O, Serban E, Bota S

Drug Design, Development and Therapy 2018, 12:1545-1566

Published Date: 31 May 2018

Formulation and in vitro characterization of rifampicin-loaded porous poly (ε-caprolactone) microspheres for sustained skeletal delivery

Mei Q, Luo P, Zuo Y, Li J, Zou Q, Li Y, Jiang D, Wang Y

Drug Design, Development and Therapy 2018, 12:1533-1544

Published Date: 31 May 2018

Incidence and risk of cardiac toxicities in patients with relapsed and refractory multiple myeloma treated with carfilzomib

Zhao F, Yang B, Wang J, Zhang R, Liu J, Yin F, Xu W, He C

Drug Design, Development and Therapy 2018, 12:1525-1531

Published Date: 30 May 2018

Spotlight on olaparib in the treatment of BRCA-mutated ovarian cancer: design, development and place in therapy

Lorusso D, Tripodi E, Maltese G, Lepori S, Sabatucci I, Bogani G, Raspagliesi F

Drug Design, Development and Therapy 2018, 12:1501-1509

Published Date: 29 May 2018

Pharmacological activities, mechanisms of action, and safety of salidroside in the central nervous system

Zhong ZF, Han J, Zhang JZ, Xiao Q, Hu J, Chen LD

Drug Design, Development and Therapy 2018, 12:1479-1489

Published Date: 24 May 2018

Synthesis and evaluation of ortho-[18F]fluorocelecoxib for COX-2 cholangiocarcinoma imaging

Chang CW, Yeh CN, Chung YH, Chen YR, Tien SW, Chen TW, Farn SS, Huang YC, Yu CS

Drug Design, Development and Therapy 2018, 12:1467-1478

Published Date: 24 May 2018

nab-Paclitaxel/carboplatin in elderly patients with advanced squamous non-small cell lung cancer: a retrospective analysis of a Phase III trial

Gridelli C, Chen T, Ko A, O'Brien ME, Ong TJ, Socinski MA, Postmus PE

Drug Design, Development and Therapy 2018, 12:1445-1451

Published Date: 24 May 2018

In silico and in vivo characterization of cabralealactone, solasodin and salvadorin in a rat model: potential anti-inflammatory agents

Malik A, Arooj M, Butt TT, Zahid S, Zahid F, Jafar TH, Waquar S, Gan SH, Ahmad S, Mirza MU

Drug Design, Development and Therapy 2018, 12:1431-1443

Published Date: 24 May 2018

The anti-cataract molecular mechanism study in selenium cataract rats for baicalin ophthalmic nanoparticles

Li N, Han Z, Li L, Zhang B, Liu Z, Li J

Drug Design, Development and Therapy 2018, 12:1399-1411

Published Date: 23 May 2018

Effects of hemocoagulase agkistrodon on the coagulation factors and its procoagulant activities

Li H, Huang Y, Wu X, Wu T, Cao Y, Wang Q, Qiu Y, Fu W, Zhang Q, Pang J

Drug Design, Development and Therapy 2018, 12:1385-1398

Published Date: 23 May 2018

Antihyperglycemic and anti-inflammatory effects of fermented food paste in high-fat diet and streptozotocin-challenged mice

Zulkawi N, Ng KH, Zamberi NR, Yeap SK, Satharasinghe DA, Tan SW, Ho WY, Abd Rashid NY, Md Lazim MI, Jamaluddin A, Alitheen NB, Long K

Drug Design, Development and Therapy 2018, 12:1373-1383

Published Date: 23 May 2018

REST, not REST4, is a risk factor associated with radiotherapy plus chemotherapy efficacy in glioma

Li C, Zou H, Wang ZF, Tang X, Fan X, Zhang K, Liu J, Li Z

Drug Design, Development and Therapy 2018, 12:1363-1371

Published Date: 22 May 2018

Immature platelets and antiplatelet therapy response to aspirin in Kawasaki disease

Pi L, Che D, Long HF, Fang ZZ, Li JW, Lin SY, Liu YF, Li M, Bao LJ, Li W, Zhang Y, Deng QL, Liu TC, Zhang L, Gu XQ

Drug Design, Development and Therapy 2018, 12:1353-1362

Published Date: 23 May 2018

Assessment of the effects of levosimendan and thymoquinone on lung injury after myocardial ischemia reperfusion in rats

Sezen SC, Kucuk A, Özer A, Kılıç Y, Mardin B, Alkan M, Erkent FD, Arslan M, Ünal Y, Oktar GL, Tosun M

Drug Design, Development and Therapy 2018, 12:1347-1352

Published Date: 22 May 2018

Design and preparation of derivatives of oleanolic and glycyrrhetinic acids with cytotoxic properties

Wang R, Li Y, Huai XD, Zheng QX, Wang W, Li HJ, Huai QY

Drug Design, Development and Therapy 2018, 12:1321-1336

Published Date: 21 May 2018

Glycyrrhizic acid ameliorates myocardial ischemic injury by the regulation of inflammation and oxidative state

Xu CL, Liang CH, Sun WX, Chen JD, Chen XH

Drug Design, Development and Therapy 2018, 12:1311-1319

Published Date: 18 May 2018

Vicenin-2 inhibits Wnt/β-catenin signaling and induces apoptosis in HT-29 human colon cancer cell line

Yang D, Zhang X, Zhang W, Rengarajan T

Drug Design, Development and Therapy 2018, 12:1303-1310

Published Date: 18 May 2018

Rapeseed protein-derived antioxidant peptide RAP alleviates renal fibrosis through MAPK/NF-κB signaling pathways in diabetic nephropathy

Zhang M, Yan Z, Bu L, An C, Wang D, Liu X, Zhang J, Yang W, Deng BC, Xie J, Zhang B

Drug Design, Development and Therapy 2018, 12:1255-1268

Published Date: 15 May 2018

Computer-aided design of amino acid-based therapeutics: a review

Farhadi T, Hashemian SM

Drug Design, Development and Therapy 2018, 12:1239-1254

Published Date: 14 May 2018

Semen Brassicae ameliorates hepatic fibrosis by regulating transforming growth factor-β1/Smad, nuclear factor-κB, and AKT signaling pathways in rats

Cao S, Zheng B, Chen T, Chang X, Yin B, Huang ZH, Shuai P, Han L

Drug Design, Development and Therapy 2018, 12:1205-1213

Published Date: 11 May 2018

Schisandrin B ameliorated chondrocytes inflammation and osteoarthritis via suppression of NF-κB and MAPK signal pathways

Ran J, Ma C, Xu K, Xu L, He Y, Moqbel SAA, Hu P, Jiang L, Chen W, Bao J, Xiong Y, Wu L

Drug Design, Development and Therapy 2018, 12:1195-1204

Published Date: 9 May 2018

Insight into resistance mechanism of anaplastic lymphoma kinase to alectinib and JH-VIII-157-02 caused by G1202R solvent front mutation

Wang H, Wang Y, Guo W, Du B, Huang X, Wu R, Yang B, Lin X, Wu Y

Drug Design, Development and Therapy 2018, 12:1183-1193

Published Date: 9 May 2018

The cytochrome P450 isoenzyme and some new opportunities for the prediction of negative drug interaction in vivo

Sychev DA, Ashraf GM, Svistunov AA, Maksimov ML, Tarasov VV, Chubarev VN, Otdelenov VA, Denisenko NP, Barreto GE, Aliev G

Drug Design, Development and Therapy 2018, 12:1147-1156

Published Date: 8 May 2018

Identification of Mycobacterium tuberculosis BioA inhibitors by using structure-based virtual screening

Singh S, Khare G, Bahal RK, Ghosh PC, Tyagi AK

Drug Design, Development and Therapy 2018, 12:1065-1079

Published Date: 1 May 2018

Inactivation of nuclear factor κB by MIP-based drug combinations augments cell death of breast cancer cells

Subramaniam M, Liew SK, In LLA, Awang K, Ahmed N, Nagoor NH

Drug Design, Development and Therapy 2018, 12:1053-1063

Published Date: 1 May 2018

Pharmacokinetic characteristics of telaprevir in healthy Korean male subjects and comparisons with Japanese

Choi Y, Yoon S, Matsumoto K, Ohta Y, Lee S, Yu KS, Jang IJ

Drug Design, Development and Therapy 2018, 12:1045-1051

Published Date: 30 April 2018

Spotlight on isavuconazole in the treatment of invasive aspergillosis and mucormycosis: design, development, and place in therapy

Jenks JD, Salzer HJ, Prattes J, Krause R, Buchheidt D, Hoenigl M

Drug Design, Development and Therapy 2018, 12:1033-1044

Published Date: 30 April 2018

Symmetric dimeric adamantanes for exploring the structure of two viroporins: influenza virus M2 and hepatitis C virus p7

Mandour YM, Breitinger U, Ma C, Wang J, Boeckler FM, Breitinger HG, Zlotos DP

Drug Design, Development and Therapy 2018, 12:1019-1031

Published Date: 30 April 2018

Astragalus polysaccharides protect cardiac stem and progenitor cells by the inhibition of oxidative stress-mediated apoptosis in diabetic hearts

Chen W, Ju J, Yang Y, Wang H, Chen W, Zhao X, Ye H, Zhang Y

Drug Design, Development and Therapy 2018, 12:943-954

Published Date: 20 April 2018

Comparison of tadalafil pharmacokinetics after administration of a new orodispersible film versus a film-coated tablet

Park SI, Heo SH, Kim G, Chang S, Song KH, Kim MG, Jin EH, Kim J, Lee S, Hong JH

Drug Design, Development and Therapy 2018, 12:935-942

Published Date: 20 April 2018

Chitosan–alginate BSA-gel-capsules for local chemotherapy against drug-resistant breast cancer

Shen H, Li F, Wang D, Yang Z, Yao C, Ye Y, Wang X

Drug Design, Development and Therapy 2018, 12:921-934

Published Date: 19 April 2018

Design, synthesis, and structure–activity relationships of 2-benzylidene-1-indanone derivatives as anti-inflammatory agents for treatment of acute lung injury

Xiao S, Zhang W, Chen H, Fang B, Qiu Y, Chen X, Chen L, Shu S, Zhang Y, Zhao Y, Liu Z, Liang G

Drug Design, Development and Therapy 2018, 12:887-899

Published Date: 19 April 2018

Population pharmacokinetics and dosing optimization of cefathiamidine in children with hematologic infection

Zhi LJ, Wang L, Chen XK, Zhai XY, Wen L, Dong L, Jacqz-Aigrain E, Shi ZR, Zhao W

Drug Design, Development and Therapy 2018, 12:855-862

Published Date: 17 April 2018

Reevaluation of the post-marketing safety of Shuxuening injection based on real-world and evidence-based evaluations

Wang C, Shi QP, Ding F, Jiang XD, Tang W, Yu ML, Zhu JH

Drug Design, Development and Therapy 2018, 12:757-767

Published Date: 5 April 2018

Chrysin suppresses proliferation, migration, and invasion in glioblastoma cell lines via mediating the ERK/Nrf2 signaling pathway

Wang J, Wang HD, Sun KJ, Wang XL, Pan H, Zhu JH, Ji XJ, Li X

Drug Design, Development and Therapy 2018, 12:721-733

Published Date: 3 April 2018

Preparation and in vitro/in vivo evaluation of PLGA microspheres containing norquetiapine for long-acting injection

Park CW, Lee HJ, Oh DW, Kang JH, Han CS, Kim DW

Drug Design, Development and Therapy 2018, 12:711-719

Published Date: 5 April 2018

Organic mononitrites of 1,2-propanediol act as an effective NO-releasing vasodilator in pulmonary hypertension and exhibit no cross-tolerance with nitroglycerin in anesthetized pigs

Nilsson KF, Goździk W, Frostell C, Zieliński S, Zielińska M, Ratajczak K, Skrzypczak P, Rodziewicz S, Albert J, Gustafsson LE

Drug Design, Development and Therapy 2018, 12:685-694

Published Date: 29 March 2018

The role of propranolol as a radiosensitizer in gastric cancer treatment

Liao XH, Chaudhary P, Qiu G, Che XM, Fan L

Drug Design, Development and Therapy 2018, 12:639-645

Published Date: 28 March 2018

Benralizumab in the treatment of severe asthma: design, development and potential place in therapy

Pelaia C, Vatrella A, Bruni A, Terracciano R, Pelaia G

Drug Design, Development and Therapy 2018, 12:619-628

Published Date: 21 March 2018

Rucaparib: a novel PARP inhibitor for BRCA advanced ovarian cancer

Colombo I, Lheureux S, Oza AM

Drug Design, Development and Therapy 2018, 12:605-617

Published Date: 21 March 2018

Tendinopathy: injury, repair, and current exploration

Lipman K, Wang CC, Ting K, Soo C, Zheng Z

Drug Design, Development and Therapy 2018, 12:591-603

Published Date: 20 March 2018

The hydroxypropyl–β-cyclodextrin complexation of toltrazuril for enhancing bioavailability

Zhang L, Liu MX, Lu CC, Ren DD, Fan GQ, Liu C, Liu MJ, Shu G, Peng GN, Yuan ZX, Zhong ZJ, Zhang W, Fu HL

Drug Design, Development and Therapy 2018, 12:583-589

Published Date: 19 March 2018

Bioequivalence of a biosimilar enoxaparin sodium to Clexane® after single 100 mg subcutaneous dose: results of a randomized, double-blind, crossover study in healthy volunteers

Martínez González J, Monreal M, Ayani Almagia I, Llaudó Garín J, Ochoa Díaz de Monasterioguren L, Gutierro Adúriz I

Drug Design, Development and Therapy 2018, 12:575-582

Published Date: 19 March 2018

Pharmacokinetic and bioequivalence study of a telmisartan/S-amlodipine fixed-dose combination (CKD-828) formulation and coadministered telmisartan and S-amlodipine in healthy subjects

Kang WY, Seong SJ, Ohk B, Gwon M, Kim BK, La S, Kim HJ, Cho S, Yoon Y, Yang DH, Lee HW

Drug Design, Development and Therapy 2018, 12:545-553

Published Date: 14 March 2018

Involvement of NF-κB and HSP70 signaling pathways in the apoptosis of MDA-MB-231 cells induced by a prenylated xanthone compound, α-mangostin, from Cratoxylum arborescens [Corrigendum] [Retraction]

Ibrahim MY, Mohd Hashim N, Mohan S, Mohd Ali H, Abdelwahab S, Kamalidehghan B, Ghaderian M, Dehghan F, Salim LZ, Karimian H, Yahayu M, Ee Cheng Lian G, Abdulla M, Farjam AS

Drug Design, Development and Therapy 2018, 12:533-534

Published Date: 13 March 2018

Can dexmedetomidine reduce atrial fibrillation after cardiac surgery? A systematic review and meta-analysis

Zhu ZP, Zhou HM, Ni YJ, Wu C, Zhang CJ, Ling XY

Drug Design, Development and Therapy 2018, 12:521-531

Published Date: 12 March 2018

Inhibitory effect of celecoxib on agomelatine metabolism in vitro and in vivo

He JY, Fang P, Zheng X, Wang CC, Liu TH, Zhang BW, Wen J, Xu RA

Drug Design, Development and Therapy 2018, 12:513-519

Published Date: 9 March 2018

Development of small bisquaternary cholinesterase inhibitors as drugs for pre-treatment of nerve agent poisonings

Kuca K, Karasova JZ, Soukup O, Kassa J, Novotna E, Sepsova V, Horova A, Pejchal J, Hrabinova M, Vodakova E, Jun D, Nepovimova E, Valis M, Musilek K

Drug Design, Development and Therapy 2018, 12:505-512

Published Date: 9 March 2018

Synovial tissue quantitative proteomics analysis reveals paeoniflorin decreases LIFR and ASPN proteins in experimental rheumatoid arthritis

Yang S, Xing ZH, Liu T, Zhou J, Liang QH, Tang T, Cui HJ, Peng WJ, Xiong XG, Wang Y

Drug Design, Development and Therapy 2018, 12:463-473

Published Date: 6 March 2018

Intra-articular platelet-rich plasma versus hyaluronic acid in the treatment of knee osteoarthritis: a meta-analysis

Zhang HF, Wang CG, Li H, Huang YT, Li ZJ

Drug Design, Development and Therapy 2018, 12:445-453

Published Date: 5 March 2018

Efficacy of atorvastatin on the prevention of contrast-induced acute kidney injury: a meta-analysis

Liu L, Liu Y, Wu M, Sun Y, Ma F

Drug Design, Development and Therapy 2018, 12:437-444

Published Date: 2 March 2018

Risk factors for calcineurin inhibitor nephrotoxicity after renal transplantation: a systematic review and meta-analysis

Xia T, Zhu S, Wen Y, Gao S, Li M, Tao X, Zhang F, Chen W

Drug Design, Development and Therapy 2018, 12:417-428

Published Date: 28 February 2018

Magnesium: does it reduce ischemia/reperfusion injury in an adnexal torsion rat model?

Celik Kavak E, Gulcu Bulmus F, Bulmus O, Kavak SB, Kocaman N

Drug Design, Development and Therapy 2018, 12:409-415

Published Date: 28 February 2018

Fasudil inhibits proliferation and migration of Hep-2 laryngeal carcinoma cells

Zhang X, Wu N

Drug Design, Development and Therapy 2018, 12:373-381

Published Date: 23 February 2018

Therapeutic potential of bimatoprost for the treatment of eyebrow hypotrichosis

Chanasumon N, Sriphojanart T, Suchonwanit P

Drug Design, Development and Therapy 2018, 12:365-372

Published Date: 22 February 2018

Formulation design and development of matrix diffusion controlled transdermal drug delivery of glimepiride

Akram MR, Ahmad M, Abrar A, Sarfraz RM, Mahmood A

Drug Design, Development and Therapy 2018, 12:349-364

Published Date: 21 February 2018

Short-term efficacy of intravitreal conbercept in treatment-naive patients with polypoidal choroidal vasculopathy

Peng Y, Zhang X, Li M, Liu B, Mi L, Zuo C, Wen F

Drug Design, Development and Therapy 2018, 12:339-345

Published Date: 19 February 2018

Pharmacokinetics and tolerability of eletriptan hydrobromide in healthy Korean subjects

Kim YK, Shin KH, Alderman J, Yu KS, Jang IJ, Lee S

Drug Design, Development and Therapy 2018, 12:331-337

Published Date: 19 February 2018

Berberine nanoparticles with enhanced in vitro bioavailability: characterization and antimicrobial activity

Sahibzada MUK, Sadiq A, Faidah HS, Khurram M, Amin MU, Haseeb A, Kakar M

Drug Design, Development and Therapy 2018, 12:303-312

Published Date: 14 February 2018

Comparison of the long-term efficacy and safety of generic tacrolimus, Tacrobell, with Prograf in liver transplant recipients

Choi HJ, Kim DG, Kwak BJ, Han JH, Hong TH, You YK

Drug Design, Development and Therapy 2018, 12:295-301

Published Date: 13 February 2018

Asthma and poly(ADP-ribose) polymerase inhibition: a new therapeutic approach

Zaffini R, Gotte G, Menegazzi M

Drug Design, Development and Therapy 2018, 12:281-293

Published Date: 12 February 2018

Reference ranges for antiepileptic drugs revisited: a practical approach to establish national guidelines

Reimers A, Berg JA, Burns ML, Brodtkorb E, Johannessen SI, Johannessen Landmark C

Drug Design, Development and Therapy 2018, 12:271-280

Published Date: 8 February 2018

Experimental and molecular modeling approach to optimize suitable polymers for fabrication of stable fluticasone nanoparticles with enhanced dissolution and antimicrobial activity

Ahmed S, Govender T, Khan I, ur Rehman N, Ali W, Shah SMH, Khan S, Hussain Z, Ullah R, Alsaid MS

Drug Design, Development and Therapy 2018, 12:255-269

Published Date: 5 February 2018

Dysregulation of Neuregulin-1/ErbB signaling in the hippocampus of rats after administration of doxorubicin

Liao D, Guo Y, Xiang D, Dang R, Xu P, Cai H, Cao L, Jiang P

Drug Design, Development and Therapy 2018, 12:231-239

Published Date: 30 January 2018

Durvalumab: an investigational anti-PD-L1 monoclonal antibody for the treatment of urothelial carcinoma

Faiena I, Cummings AL, Crosetti AM, Pantuck AJ, Chamie K, Drakaki A

Drug Design, Development and Therapy 2018, 12:209-215

Published Date: 23 January 2018

Bispecific antibodies: design, therapy, perspectives

Sedykh SE, Prinz VV, Buneva VN, Nevinsky GA

Drug Design, Development and Therapy 2018, 12:195-208

Published Date: 22 January 2018

Anticonvulsant and reproductive toxicological studies of the imidazole-based histamine H3R antagonist 2-18 in mice

Bastaki SM, Abdulrazzaq YM, Shafiullah M, Więcek M, Kieć-Kononowicz K, Sadek B

Drug Design, Development and Therapy 2018, 12:179-194

Published Date: 19 January 2018

Involvement of microRNA-146a in diabetic peripheral neuropathy through the regulation of inflammation

Feng Y, Chen L, Luo Q, Wu M, Chen Y, Shi X

Drug Design, Development and Therapy 2018, 12:171-177

Published Date: 17 January 2018

Efficacy and side effects of intravenous theophylline in acute asthma: a systematic review and meta-analysis

Mahemuti G, Zhang H, Li J, Tieliwaerdi N, Ren L

Drug Design, Development and Therapy 2018, 12:99-120

Published Date: 10 January 2018

Peptides derived from Plasmodium falciparum leucine-rich repeat 1 bind to serine/threonine phosphatase type 1 and inhibit parasite growth in vitro

Pierrot C, Zhang X, Zanghi G, Fréville A, Rebollo A, Khalife J

Drug Design, Development and Therapy 2018, 12:85-88

Published Date: 9 January 2018

Quantitative assessment of the effects of chitosan intervention on blood pressure control

Huang H, Zou Y, Chi H

Drug Design, Development and Therapy 2018, 12:67-75

Published Date: 28 December 2017

The oral bioavailability, excretion and cytochrome P450 inhibition properties of epiberberine: an in vivo and in vitro evaluation

Chen N, Yang X, Guo C, Bi X, Chen J, Chen H, Li H, Lin H, Zhang Y

Drug Design, Development and Therapy 2018, 12:57-65

Published Date: 28 December 2017

Portulaca oleracea L. alleviates liver injury in streptozotocin-induced diabetic mice

Zheng G, Mo F, Ling C, Peng H, Gu W, Li M, Chen Z

Drug Design, Development and Therapy 2018, 12:47-55

Published Date: 28 December 2017

Clinical features of hypophosphatemic osteomalacia induced by long-term low-dose adefovir dipivoxil

Zhu S, Yang YH, Gao RW, Li R, Zou YZ, Feng L, Zhang B

Drug Design, Development and Therapy 2018, 12:41-45

Published Date: 27 December 2017

Leishmaniasis in humans: drug or vaccine therapy?

Ghorbani M, Farhoudi R

Drug Design, Development and Therapy 2018, 12:25-40

Published Date: 22 December 2017

Intra-articular collagenase injection increases range of motion in a rat knee flexion contracture model

Wong K, Trudel G, Laneuville O

Drug Design, Development and Therapy 2018, 12:15-24

Published Date: 21 December 2017

HX575: established biosimilarity in the treatment of renal anemia and 10 years of clinical experience

Dellanna F, Goldsmith D, Krendyukov A, Seidl A, Höbel N, Combe C

Drug Design, Development and Therapy 2018, 12:9-14

Published Date: 18 December 2017