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Drug Design, Development and Therapy
ISSN: 1177-8881
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Archive: Volume 11, 2017
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- Ten Years of Biosimilars in Europe (4)
Resveratrol as a potential therapeutic drug for respiratory system diseases
Zhu X, Lei X, Dong W
Drug Design, Development and Therapy 2017, 11:3591-3598
Published Date: 15 December 2017
Guideline development for the management of gout: role of combination therapy with a focus on lesinurad [Corrigendum]
Jones G, Panova E, Day R
Drug Design, Development and Therapy 2017, 11:3589-3590
Published Date: 15 December 2017
Spotlight on olaratumab in the treatment of soft-tissue sarcoma: design, development, and place in therapy
Davis EJ, Chugh R
Drug Design, Development and Therapy 2017, 11:3579-3587
Published Date: 13 December 2017
Astragaloside IV protects rat retinal capillary endothelial cells against high glucose-induced oxidative injury
Qiao Y, Fan C, Tang M
Drug Design, Development and Therapy 2017, 11:3567-3577
Published Date: 13 December 2017
Spotlight on solithromycin in the treatment of community-acquired bacterial pneumonia: design, development, and potential place in therapy
Donald BJ, Surani S, Deol HS, Mbadugha UJ, Udeani G
Drug Design, Development and Therapy 2017, 11:3559-3566
Published Date: 13 December 2017
EUREKA study – the evaluation of real-life use of a biophotonic system in chronic wound management: an interim analysis
Romanelli M, Piaggesi A, Scapagnini G, Dini V, Janowska A, Iacopi E, Scarpa C, Fauverghe S, Bassetto F
Drug Design, Development and Therapy 2017, 11:3551-3558
Published Date: 11 December 2017
Comparative pharmacokinetics of a fixed-dose combination vs concomitant administration of telmisartan and S-amlodipine in healthy adult volunteers
Oh M, Park SE, Ghim JL, Choi YK, Shim EJ, Shin JG, Kim EY
Drug Design, Development and Therapy 2017, 11:3543-3550
Published Date: 11 December 2017
Gut microbiota–derived short-chain fatty acids and kidney diseases
Li L, Ma L, Fu P
Drug Design, Development and Therapy 2017, 11:3531-3542
Published Date: 11 December 2017
Redox-responsive and pH-sensitive nanoparticles enhanced stability and anticancer ability of erlotinib to treat lung cancer in vivo
Tan S, Wang G
Drug Design, Development and Therapy 2017, 11:3519-3529
Published Date: 8 December 2017
Regulation profile of the intestinal peptide transporter 1 (PepT1)
Wang CY, Liu S, Xie XN, Tan ZR
Drug Design, Development and Therapy 2017, 11:3511-3517
Published Date: 8 December 2017
Functional assessment of CYP3A4 allelic variants on lidocaine metabolism in vitro
Fang P, Tang P, Xu R, Zheng X, Wen J, Bao S, Cai J, Hu G
Drug Design, Development and Therapy 2017, 11:3503-3510
Published Date: 7 December 2017
Anacetrapib as a potential cardioprotective strategy
Di Bartolo BA, Nicholls SJ
Drug Design, Development and Therapy 2017, 11:3497-3502
Published Date: 7 December 2017
Involvement of poly(ADP-ribose) polymerase-1 in development of spinal cord injury in Chinese individuals: a Chinese clinical study
Meng Q, Yang G, Li R, Nie J, Zhou W, Yu H, Chen B, Jiang L, Shang J
Drug Design, Development and Therapy 2017, 11:3491-3495
Published Date: 6 December 2017
Preparation and evaluation of RGD and TAT co-modified docetaxel-loaded liposome
Zhu R, Tian Y
Drug Design, Development and Therapy 2017, 11:3481-3489
Published Date: 6 December 2017
Variability in the therapeutic management of advanced ovarian cancer patients: a five-country survey of oncologists
Audibert C, Perlaky A, Stuntz M, Glass D
Drug Design, Development and Therapy 2017, 11:3471-3479
Published Date: 6 December 2017
Pharmacokinetic and pharmacodynamic interaction between ezetimibe and rosuvastatin in healthy male subjects
Kim CH, An H, Kim SH, Shin D
Drug Design, Development and Therapy 2017, 11:3461-3469
Published Date: 5 December 2017
Hepatoprotective effect of calculus bovis sativus on nonalcoholic fatty liver disease in mice by inhibiting oxidative stress and apoptosis of hepatocytes
He WX, Xu YJ, Zhang CL, Lu JL, Li J, Xiang D, Yang JY, Chang MJ, Liu D
Drug Design, Development and Therapy 2017, 11:3449-3460
Published Date: 5 December 2017
Bioequivalence study of two formulations of flupirtine maleate capsules in healthy male Chinese volunteers under fasting and fed conditions
Liu YF, Huo H, Zhao ZB, Hu WL, Sun YJ, Tang YB
Drug Design, Development and Therapy 2017, 11:3441-3448
Published Date: 1 December 2017
The role of maintenance therapy in the treatment of elderly non-small-cell lung cancer patients: a meta-analysis of randomized controlled trials
Zhang L, Gao S, He J
Drug Design, Development and Therapy 2017, 11:3435-3440
Published Date: 1 December 2017
High-dose atorvastatin versus moderate dose on early vascular protection after ST-elevation myocardial infarction
Gavazzoni M, Gorga E, Derosa G, Maffioli P, Metra M, Raddino R
Drug Design, Development and Therapy 2017, 11:3425-3434
Published Date: 4 December 2017
Comparison of dexmedetomidine and fentanyl as local anesthetic adjuvants in spinal anesthesia: a systematic review and meta-analysis of randomized controlled trials
Sun S, Wang J, Bao N, Chen Y, Wang J
Drug Design, Development and Therapy 2017, 11:3413-3424
Published Date: 1 December 2017
Cardiovascular, liver, and renal toxicity associated with an intravenous ferric carboxymaltose similar versus the originator compound
Toblli JE, Cao G, Rico L, Angerosa M
Drug Design, Development and Therapy 2017, 11:3401-3412
Published Date: 30 November 2017
Synthesis, characterization, and antimicrobial evaluation of novel 5-benzoyl-N-substituted amino- and 5-benzoyl-N-sulfonylamino-4-alkylsulfanyl-2-pyridones
Elgemeie G, Altalbawy F, Alfaidi M, Azab R, Hassan A
Drug Design, Development and Therapy 2017, 11:3389-3399
Published Date: 28 November 2017
A novel transdermal nanoethosomal gel of betahistine dihydrochloride for weight gain control: in-vitro and in-vivo characterization
El-Menshawe SF, Ali AA, Halawa AA, Srag El-Din AS
Drug Design, Development and Therapy 2017, 11:3377-3388
Published Date: 28 November 2017
The coexpression of multi-immune inhibitory receptors on T lymphocytes in primary non-small-cell lung cancer
Guo WJ, Liu SH, Zhang XL, Chen YT, Qian RL, Zou ZY, Chen X, Luo P
Drug Design, Development and Therapy 2017, 11:3367-3376
Published Date: 28 November 2017
Risperidone mucoadhesive buccal tablets: formulation design, optimization and evaluation
Çelik B
Drug Design, Development and Therapy 2017, 11:3355-3365
Published Date: 27 November 2017
Notoginsenoside R1 attenuates high glucose-induced endothelial damage in rat retinal capillary endothelial cells by modulating the intracellular redox state
Fan CL, Qiao Y, Tang MK
Drug Design, Development and Therapy 2017, 11:3343-3354
Published Date: 23 November 2017
Andrographolide enhanced 5-fluorouracil-induced antitumor effect in colorectal cancer via inhibition of c-MET pathway
Su M, Qin B, Liu F, Chen Y, Zhang R
Drug Design, Development and Therapy 2017, 11:3333-3341
Published Date: 23 November 2017
Fentanyl-induced respiratory depression is attenuated in pregnant patients
Cao X, Liu S, Sun J, Yu M, Fang Y, Ding Z
Drug Design, Development and Therapy 2017, 11:3325-3332
Published Date: 22 November 2017
Severe hypertriglyceridemia and colchicine intoxication following suicide attempt
Lev S, Snyder D, Azran C, Zolotarsky V, Dahan A
Drug Design, Development and Therapy 2017, 11:3321-3324
Published Date: 22 November 2017
Anticancer effect of dentatin and dentatin-hydroxypropyl-β-cyclodextrin complex on human colon cancer (HT-29) cell line
AL-Abboodi AS, Rasedee A, Abdul AB, Taufiq-Yap YH, Alkaby WA, Ghaji MS, Waziri PM, Al-Qubaisi MS
Drug Design, Development and Therapy 2017, 11:3309-3319
Published Date: 23 November 2017
Efficacy and safety of quadruple therapy including tirofiban in the treatment of Chinese NSTE-ACS patients failing to receive timely percutaneous coronary intervention
Li L, Ge Z, Zhang D, Kuang J, Ma X, Jiang S
Drug Design, Development and Therapy 2017, 11:3299-3307
Published Date: 21 November 2017
Pharmacodynamic testing and new validated HPLC method to assess the interchangeability between multi-source orlistat capsules
Zaid AN, Zohud N, E'layan B, Aburadi T, Jaradat N, Ali I, Hussein F, Ghanem M, Qaddomi A, Abu Zaaror Y
Drug Design, Development and Therapy 2017, 11:3291-3298
Published Date: 21 November 2017
In silico-based identification of human α-enolase inhibitors to block cancer cell growth metabolically
Lung J, Chen KL, Hung CH, Chen CC, Hung MS, Lin YC, Wu CY, Lee KD, Shih NY, Tsai YH
Drug Design, Development and Therapy 2017, 11:3281-3290
Published Date: 16 November 2017
Differences of statin activity in 2D and 3D pancreatic cancer cell cultures
Paškevičiūtė M, Petrikaitė V
Drug Design, Development and Therapy 2017, 11:3273-3280
Published Date: 16 November 2017
Role of nebulized glycopyrrolate in the treatment of chronic obstructive pulmonary disease
Santus P, Radovanovic D, Cristiano A, Valenti V, Rizzi M
Drug Design, Development and Therapy 2017, 11:3257-3271
Published Date: 15 November 2017
Adjuvant immunotherapy of dendritic cells and cytokine-induced killer cells is safe and enhances chemotherapy efficacy for multiple myeloma in China: a meta-analysis of clinical trials
Wang Y, Lv BJ, Li K, Zhang AQ, Liu H
Drug Design, Development and Therapy 2017, 11:3245-3256
Published Date: 15 November 2017
Safety and efficacy of the addition of pertuzumab to T-DM1 ± taxane in patients with HER2-positive, locally advanced or metastatic breast cancer: a pooled analysis
Zhang J, Li J, Zhu C, Song Y, Xia F, Ma X
Drug Design, Development and Therapy 2017, 11:3235-3244
Published Date: 15 November 2017
Paeoniflorin attenuates incipient diabetic nephropathy in streptozotocin-induced mice by the suppression of the Toll-like receptor-2 signaling pathway
Shao YX, Xu XX, Wang K, Qi XM, Wu YG
Drug Design, Development and Therapy 2017, 11:3221-3233
Published Date: 9 November 2017
Novel production method of innovative antiangiogenic and antitumor small peptides in Escherichia coli
Setrerrahmane S, Yu J, Hao J, Zheng H, Xu H
Drug Design, Development and Therapy 2017, 11:3207-3220
Published Date: 8 November 2017
Quantum mechanics implementation in drug-design workflows: does it really help? [Corrigendum]
Arodola OA, Soliman MES
Drug Design, Development and Therapy 2017, 11:3205-3206
Published Date: 8 November 2017
Tenofovir alafenamide in the treatment of chronic hepatitis B: design, development, and place in therapy
Ogawa E, Furusyo N, Nguyen MH
Drug Design, Development and Therapy 2017, 11:3197-3204
Published Date: 6 November 2017
Pharmacokinetics and tolerability of MB12066, a beta-lapachone derivative targeting NAD(P)H:quinone oxidoreductase 1: two independent, double-blind, placebo-controlled, combined single and multiple ascending dose first-in-human clinical trials
Kim S, Lee S, Cho JY, Yoon SH, Jang IJ, Yu KS
Drug Design, Development and Therapy 2017, 11:3187-3195
Published Date: 7 November 2017
Impact of baseline blood pressure on the magnitude of blood pressure lowering by nifedipine gastrointestinal therapeutic system: refreshing the Wilder’s principle
Hu HJ, Zhang JD, Wang Y, Tian ZJ, Liu DM, Zhang GM, Gu GQ, Zheng HM, Xie RQ, Cui W
Drug Design, Development and Therapy 2017, 11:3179-3186
Published Date: 6 November 2017
A comparative pharmacokinetic and tolerability analysis of the novel orotic acid salt form of tenofovir disoproxil and the fumaric acid salt form in healthy subjects
Kim YK, Choi MJ, Oh TY, Yu KS, Lee S
Drug Design, Development and Therapy 2017, 11:3171-3177
Published Date: 6 November 2017
Development of novel ultrashort antimicrobial peptide nanoparticles with potent antimicrobial and antibiofilm activities against multidrug-resistant bacteria
Almaaytah A, Mohammed GK, Abualhaijaa A, Al-Balas Q
Drug Design, Development and Therapy 2017, 11:3159-3170
Published Date: 3 November 2017
Spotlight on siponimod and its potential in the treatment of secondary progressive multiple sclerosis: the evidence to date
Gajofatto A
Drug Design, Development and Therapy 2017, 11:3153-3157
Published Date: 2 November 2017
Baracle® vs Baraclude® for 48 weeks in patients with treatment-naïve chronic hepatitis B: a comparison of efficacy and safety
Kim DY, Kim JH, Tak WY, Yeon JE, Lee JH, Yoon JH, Lee YJ, Lee BS, Han BH, Lee HC
Drug Design, Development and Therapy 2017, 11:3145-3152
Published Date: 31 October 2017
Severe eosinophilic asthma: from the pathogenic role of interleukin-5 to the therapeutic action of mepolizumab
Pelaia C, Vatrella A, Busceti MT, Gallelli L, Terracciano R, Savino R, Pelaia G
Drug Design, Development and Therapy 2017, 11:3137-3144
Published Date: 30 October 2017
Comparable pharmacokinetics and pharmacodynamics of two epoetin alfa formulations Eporon® and Eprex® following a single subcutaneous administration in healthy male volunteers
Yoon S, Rhee SJ, Heo SJ, Oh TY, Yoon SH, Cho JY, Lee S, Yu KS
Drug Design, Development and Therapy 2017, 11:3127-3135
Published Date: 27 October 2017
Vitamin D levels in systemic sclerosis patients: a meta-analysis
An L, Sun M, Chen F, Li J
Drug Design, Development and Therapy 2017, 11:3119-3125
Published Date: 27 October 2017
In vivo study of doxorubicin-loaded cell-penetrating peptide-modified pH-sensitive liposomes: biocompatibility, bio-distribution, and pharmacodynamics in BALB/c nude mice bearing human breast tumors
Ding Y, Cui W, Sun D, Wang GL, Hei Y, Meng S, Chen JH, Xie Y, Wang ZQ
Drug Design, Development and Therapy 2017, 11:3105-3117
Published Date: 26 October 2017
High-dose dexamethasone induced LPS-stimulated rat alveolar macrophages apoptosis
Zeng S, Qiao H, Lv XW, Fan D, Liu T, Xie D
Drug Design, Development and Therapy 2017, 11:3097-3104
Published Date: 25 October 2017
Development of β-cyclodextrin-based hydrogel microparticles for solubility enhancement of rosuvastatin: an in vitro and in vivo evaluation
Sarfraz RM, Ahmad M, Mahmood A, Akram MR, Abrar A
Drug Design, Development and Therapy 2017, 11:3083-3096
Published Date: 24 October 2017
Guideline development for the management of gout: role of combination therapy with a focus on lesinurad
Jones G, Panova E, Day R
Drug Design, Development and Therapy 2017, 11:3077-3081
Published Date: 24 October 2017
Enhanced antitumor efficacy of poly(D,L-lactide-co-glycolide)-based methotrexate-loaded implants on sarcoma 180 tumor-bearing mice
Gao L, Xia L, Zhang R, Duan D, Liu X, Xu J, Luo L
Drug Design, Development and Therapy 2017, 11:3065-3075
Published Date: 20 October 2017
10H-3,6-Diazaphenothiazine induces G2/M phase cell cycle arrest and caspase-dependent apoptosis and inhibits cell invasion of A2780 ovarian carcinoma cells through the regulation of NF-κB and (BIRC6-XIAP) complexes
Zhang J, Ming C, Zhang W, Okechukwu PN, Morak-Młodawska B, Pluta K, Jeleń M, Akim AM, Ang KP, Ooi KK
Drug Design, Development and Therapy 2017, 11:3045-3063
Published Date: 24 October 2017
Failure mode and effects analysis drastically reduced potential risks in clinical trial conduct
Lee H, Lee H, Baik J, Kim HJ, Kim R
Drug Design, Development and Therapy 2017, 11:3035-3043
Published Date: 19 October 2017
Edaravone inhibits pressure overload-induced cardiac fibrosis and dysfunction by reducing expression of angiotensin II AT1 receptor
Zhang WW, Bai F, Wang J, Zheng RH, Yang LW, James EA, Zhao ZQ
Drug Design, Development and Therapy 2017, 11:3019-3033
Published Date: 16 October 2017
Risk of severe hematologic toxicities in cancer patients treated with PARP inhibitors: a meta-analysis of randomized controlled trials
Zhou JX, Feng LJ, Zhang X
Drug Design, Development and Therapy 2017, 11:3009-3017
Published Date: 13 October 2017
Amelioration of collagen-induced arthritis using antigen-loaded dendritic cells modified with NF-κB decoy oligodeoxynucleotides
Jiang HM, Hu HG, Zhang YL, Yue P, Ning LC, Zhou Y, Shi P, Yuan R
Drug Design, Development and Therapy 2017, 11:2997-3007
Published Date: 13 October 2017
5H-benzo[h]thiazolo[2,3-b]quinazolines ameliorate NDEA-induced hepatocellular carcinogenesis in rats through IL-6 downregulation along with oxidative and metabolic stress reduction
Keshari AK, Singh AK, Kumar U, Raj V, Rai A, Kumar P, Kumar D, Maity B, Nath S, Prakash A, Saha S
Drug Design, Development and Therapy 2017, 11:2981-2995
Published Date: 13 October 2017
Protective effect of DA-9401 in finasteride-induced apoptosis in rat testis: inositol requiring kinase 1 and c-Jun N-terminal kinase pathway
Soni KK, Shin YS, Choi BR, Karna KK, Kim HK, Lee SW, Kim CY, Park JK
Drug Design, Development and Therapy 2017, 11:2969-2979
Published Date: 11 October 2017
Clinical and pharmacological hallmarks of rifapentine’s use in diabetes patients with active and latent tuberculosis: do we know enough?
Zheng C, Hu X, Zhao L, Hu M, Gao F
Drug Design, Development and Therapy 2017, 11:2957-2968
Published Date: 11 October 2017
Halofuginone ameliorates inflammation in severe acute hepatitis B virus (HBV)-infected SD rats through AMPK activation
Zhan WL, Kang YH, Chen N, Mao CS, Kang Y, Shang J
Drug Design, Development and Therapy 2017, 11:2947-2955
Published Date: 10 October 2017
Short vs prolonged dual antiplatelet treatment upon endovascular stenting of peripheral arteries
Kronlage M, Wassmann M, Vogel B, Müller OJ, Blessing E, Katus H, Erbel C
Drug Design, Development and Therapy 2017, 11:2937-2945
Published Date: 6 October 2017
Functional and morphological effects of diazepam and midazolam on tumor vasculature in the 9L gliosarcoma brain tumor model using dynamic susceptibility contrast MRI: a comparative study
Yan N, Zheng Y, Yang C
Drug Design, Development and Therapy 2017, 11:2931-2936
Published Date: 4 October 2017
Spotlight on perampanel in the management of seizures: design, development and an update on place in therapy
Faulkner MA
Drug Design, Development and Therapy 2017, 11:2921-2930
Published Date: 4 October 2017
Spotlight on ertugliflozin and its potential in the treatment of type 2 diabetes: evidence to date
Cinti F, Moffa S, Impronta F, Cefalo CMA, Sun VA, Sorice GP, Mezza T, Giaccari A
Drug Design, Development and Therapy 2017, 11:2905-2919
Published Date: 3 October 2017
Current perspective on rituximab in rheumatic diseases
Schioppo T, Ingegnoli F
Drug Design, Development and Therapy 2017, 11:2891-2904
Published Date: 3 October 2017
The new era of nanotechnology, an alternative to change cancer treatment
Jurj A, Braicu C, Pop LA, Tomuleasa C, Gherman CD, Berindan-Neagoe I
Drug Design, Development and Therapy 2017, 11:2871-2890
Published Date: 27 September 2017
New tablet formulation of tacrolimus with smaller interindividual variability may become a better treatment option than the conventional capsule formulation in organ transplant patients
Kim YK, Kim A, Park SJ, Lee H
Drug Design, Development and Therapy 2017, 11:2861-2869
Published Date: 28 September 2017
Safety and efficacy profile of pembrolizumab in solid cancer: pooled reanalysis based on randomized controlled trials
Wang MN, Ma XL, Guo LH, Xia F
Drug Design, Development and Therapy 2017, 11:2851-2860
Published Date: 27 September 2017
Downregulation of A20 increases the cytotoxicity of IFN-γ in hepatocellular carcinoma cells
Yin L, Fang Z, Shen N, Qiu Y, Li A, Zhang Y
Drug Design, Development and Therapy 2017, 11:2841-2850
Published Date: 26 September 2017
Eluxadoline in the treatment of diarrhea-predominant irritable bowel syndrome
Özdener AE, Rivkin A
Drug Design, Development and Therapy 2017, 11:2827-2840
Published Date: 26 September 2017
Effect of echinacoside on kidney fibrosis by inhibition of TGF-β1/Smads signaling pathway in the db/db mice model of diabetic nephropathy
Tang FJ, Hao YR, Zhang X, Qin J
Drug Design, Development and Therapy 2017, 11:2813-2826
Published Date: 21 September 2017
Axitinib in the treatment of renal cell carcinoma: design, development, and place in therapy
Bellesoeur A, Carton E, Alexandre J, Goldwasser F, Huillard O
Drug Design, Development and Therapy 2017, 11:2801-2811
Published Date: 21 September 2017
Dexmedetomidine reduces the neuronal apoptosis related to cardiopulmonary bypass by inhibiting activation of the JAK2–STAT3 pathway
Chen Y, Zhang X, Zhang B, He G, Zhou L, Xie Y
Drug Design, Development and Therapy 2017, 11:2787-2799
Published Date: 26 September 2017
Assay development and high-throughput screening for small molecule inhibitors of a Vibrio cholerae stress response pathway
Stanbery L, Matson JS
Drug Design, Development and Therapy 2017, 11:2777-2785
Published Date: 19 September 2017
Anti-proliferative, apoptotic induction, and anti-migration effects of hemi-synthetic 1′S-1′-acetoxychavicol acetate analogs on MDA-MB-231 breast cancer cells
Liew SK, Azmi MN, In LLA, Awang K, Nagoor NH
Drug Design, Development and Therapy 2017, 11:2763-2776
Published Date: 18 September 2017
Biodegradable rifampicin-releasing coating of surgical meshes for the prevention of bacterial infections
Reinbold J, Hierlemann T, Urich L, Uhde AK, Müller I, Weindl T, Vogel U, Schlensak C, Wendel HP, Krajewski S
Drug Design, Development and Therapy 2017, 11:2753-2762
Published Date: 18 September 2017
Design and evaluation of lidocaine- and prilocaine-coloaded nanoparticulate drug delivery systems for topical anesthetic analgesic therapy: a comparison between solid lipid nanoparticles and nanostructured lipid carriers
You P, Yuan R, Chen C
Drug Design, Development and Therapy 2017, 11:2743-2752
Published Date: 18 September 2017
The roles of epigallocatechin-3-gallate in the treatment of neuropathic pain: an update on preclinical in vivo studies and future perspectives
Bimonte S, Cascella M, Schiavone V, Mehrabi-Kermani F, Cuomo A
Drug Design, Development and Therapy 2017, 11:2737-2742
Published Date: 13 September 2017
Variability of the drug response to nonsteroidal anti-inflammatory drugs according to cyclooxygenase-2 genetic polymorphism
Lee SJ, Park MK, Shin DS, Chun MH
Drug Design, Development and Therapy 2017, 11:2727-2736
Published Date: 13 September 2017
Pharmacokinetic and safety evaluation of MB12066, an NQO1 substrate
Lee HW, Seong SJ, Ohk B, Kang WY, Gwon MR, Kim BK, Kim HJ, Yoon YR
Drug Design, Development and Therapy 2017, 11:2719-2725
Published Date: 13 September 2017
Localized neuropathic pain: an expert consensus on local treatments
Pickering G, Martin E, Tiberghien F, Delorme C, Mick G
Drug Design, Development and Therapy 2017, 11:2709-2718
Published Date: 13 September 2017
Investigating isoquinoline derivatives for inhibition of inhibitor of apoptosis proteins for ovarian cancer treatment
Chen C, Wu J, Zhu P, Xu C, Yao L
Drug Design, Development and Therapy 2017, 11:2697-2707
Published Date: 11 September 2017
Metal organic frameworks as a drug delivery system for flurbiprofen
AL Haydar M, Abid HR, Sunderland B, Wang S
Drug Design, Development and Therapy 2017, 11:2685-2695
Published Date: 11 September 2017
Cissus quadrangularis inhibits IL-1β induced inflammatory responses on chondrocytes and alleviates bone deterioration in osteotomized rats via p38 MAPK signaling [Corrigendum]
Kanwar JR, Samarasinghe RM, Kumar K, Arya R, Sanjeev S, Zhou SF, Sasidharan S, Kanwar RK
Drug Design, Development and Therapy 2017, 11:2683-2684
Published Date: 12 September 2017
Extended infusion versus intermittent infusion of imipenem in the treatment of ventilator-associated pneumonia
Ibrahim MM, Tammam TF, Ebaed MED, Sarhan HA, Gad GF, Hussein AK
Drug Design, Development and Therapy 2017, 11:2677-2682
Published Date: 6 September 2017
The influence of goal-directed fluid therapy on the prognosis of elderly patients with hypertension and gastric cancer surgery [Retraction]
Zeng K, Li YZ, Liang M, Gao YG, Cai HD, Lin CZ
Drug Design, Development and Therapy 2017, 11:2675-2676
Published Date: 6 September 2017
Palatability and physical properties of potassium-binding resin RDX7675: comparison with sodium polystyrene sulfonate
Zann V, McDermott J, Jacobs JW, Davidson JP, Lin F, Korner P, Blanks RC, Rosenbaum DP
Drug Design, Development and Therapy 2017, 11:2663-2673
Published Date: 6 September 2017
In vitro inhibitory activities of magnolol against Candida spp.
Zhou PR, Fu JY, Hua H, Liu XS
Drug Design, Development and Therapy 2017, 11:2653-2661
Published Date: 6 September 2017
Radium 223 dichloride for prostate cancer treatment
Deshayes E, Roumiguie M, Thibault C, Beuzeboc P, Cachin F, Hennequin C, Huglo D, Rozet F, Kassab-Chahmi D, Rebillard X, Houédé N
Drug Design, Development and Therapy 2017, 11:2643-2651
Published Date: 6 September 2017
Layer-by-layer nanoparticles co-loading gemcitabine and platinum (IV) prodrugs for synergistic combination therapy of lung cancer
Zhang R, Ru Y, Gao Y, Li J, Mao S
Drug Design, Development and Therapy 2017, 11:2631-2642
Published Date: 5 September 2017
Recent developments in the clinical pharmacology of rolapitant: subanalyses in specific populations
Rapoport BL, Aapro M, Chasen MR, Jordan K, Navari RM, Schnadig I, Schwartzberg L
Drug Design, Development and Therapy 2017, 11:2621-2629
Published Date: 5 September 2017
Protective role of quercetin against manganese-induced injury in the liver, kidney, and lung; and hematological parameters in acute and subchronic rat models
Bahar E, Lee GH, Bhattarai KR, Lee HY, Kim HK, Handigund M, Choi MK, Han SY, Chae HJ, Yoon H
Drug Design, Development and Therapy 2017, 11:2605-2619
Published Date: 5 September 2017
Irinotecan and 5-fluorouracil-co-loaded, hyaluronic acid-modified layer-by-layer nanoparticles for targeted gastric carcinoma therapy
Gao Z, Li Z, Yan J, Wang P
Drug Design, Development and Therapy 2017, 11:2595-2604
Published Date: 5 September 2017
Puerarin transport across rat nasal epithelial cells and the influence of compatibility with paeoniflorin and menthol
Zhang L, Du S, Lu Y, Liu C, Wu H, Tian Z, Wang M, Yang C
Drug Design, Development and Therapy 2017, 11:2581-2593
Published Date: 1 September 2017
Alginate oligosaccharide indirectly affects toll-like receptor signaling via the inhibition of microRNA-29b in aneurysm patients after endovascular aortic repair
Yang Y, Ma Z, Yang G, Wan J, Li G, Du L, Lu P
Drug Design, Development and Therapy 2017, 11:2565-2579
Published Date: 1 September 2017
Quantum mechanics implementation in drug-design workflows: does it really help?
Arodola OA, Soliman MES
Drug Design, Development and Therapy 2017, 11:2551-2564
Published Date: 31 August 2017
Profile of pembrolizumab in the treatment of head and neck squamous cell carcinoma: design development and place in therapy
Haque S, Yellu M, Randhawa J, Hashemi-Sadraei N
Drug Design, Development and Therapy 2017, 11:2537-2549
Published Date: 31 August 2017
New insight into the pathogenesis of nail psoriasis and overview of treatment strategies
Ventura A, Mazzeo M, Gaziano R, Galluzzo M, Bianchi L, Campione E
Drug Design, Development and Therapy 2017, 11:2527-2535
Published Date: 30 August 2017
Secondary prevention of major cerebrovascular events with seven different statins: a multi-treatment meta-analysis
Zhong P, Wu D, Ye X, Wu Y, Li T, Tong S, Liu X
Drug Design, Development and Therapy 2017, 11:2517-2526
Published Date: 30 August 2017
Therapy with pamidronate in children with osteogenesis imperfecta
Marginean O, Tamasanu RC, Mang N, Mozos I, Brad GF
Drug Design, Development and Therapy 2017, 11:2507-2515
Published Date: 28 August 2017
Advances in the delivery of buprenorphine for opioid dependence
Rosenthal RN, Goradia VV
Drug Design, Development and Therapy 2017, 11:2493-2505
Published Date: 28 August 2017
Paeoniflorin suppresses pancreatic cancer cell growth by upregulating HTRA3 expression
Li YJ, Gong LL, Qi RL, Sun Q, Xia XX, He HH, Ren JS, Zhu ON, Zhuo DB
Drug Design, Development and Therapy 2017, 11:2481-2491
Published Date: 23 August 2017
Development of idursulfase therapy for mucopolysaccharidosis type II (Hunter syndrome): the past, the present and the future
Whiteman DAH, Kimura A
Drug Design, Development and Therapy 2017, 11:2467-2480
Published Date: 23 August 2017
Preliminary study of nanonized lamotrigine containing products for nasal powder formulation
Gieszinger P, Csóka I, Pallagi E, Katona G, Jójárt-Laczkovich O, Szabó-Révész P, Ambrus R
Drug Design, Development and Therapy 2017, 11:2453-2466
Published Date: 23 August 2017
Aceclofenac nanocrystals with enhanced in vitro, in vivo performance: formulation optimization, characterization, analgesic and acute toxicity studies
Rahim H, Sadiq A, Khan S, Khan MA, Shah SMH, Hussain Z, Ullah R, Shahat AA, Ibrahim K
Drug Design, Development and Therapy 2017, 11:2443-2452
Published Date: 23 August 2017
Sensitization of gastric cancer cells to alkylating agents by glaucocalyxin B via cell cycle arrest and enhanced cell death
Ur Rahman MS, Zhang L, Wu LY, Xie YQ, Li CC, Cao J
Drug Design, Development and Therapy 2017, 11:2431-2441
Published Date: 22 August 2017
Metformin: a review of its potential indications
Wang YW, He SJ, Feng X, Cheng J, Luo YT, Tian L, Huang Q
Drug Design, Development and Therapy 2017, 11:2421-2429
Published Date: 22 August 2017
A comparison of oral controlled-release morphine and oxycodone with transdermal formulations of buprenorphine and fentanyl in the treatment of severe pain in cancer patients
Nosek K, Leppert W, Nosek H, Wordliczek J, Onichimowski D
Drug Design, Development and Therapy 2017, 11:2409-2419
Published Date: 22 August 2017
Pomalidomide in the treatment of multiple myeloma: design, development and place in therapy
Rios-Tamayo R, Martín-García A, Alarcón-Payer C, Sánchez-Rodríguez D, Guardia AM, García Collado CG, Jiménez Morales A, Jurado Chacón M, Cabeza Barrera J
Drug Design, Development and Therapy 2017, 11:2399-2408
Published Date: 22 August 2017
Alginate oligosaccharide alleviates myocardial reperfusion injury by inhibiting nitrative and oxidative stress and endoplasmic reticulum stress-mediated apoptosis
Guo JJ, Xu FQ, Li YH, Li J, Liu X, Wang XF, Hu LG, An Y
Drug Design, Development and Therapy 2017, 11:2387-2397
Published Date: 18 August 2017
α-melanocyte stimulating hormone modulates the central acyl ghrelin-induced stimulation of feeding, gastrointestinal motility, and colonic secretion
Huang HH, Chen LY, Doong ML, Chang SC, Chen CY
Drug Design, Development and Therapy 2017, 11:2377-2386
Published Date: 16 August 2017
Onychomadesis associated with chemotherapy: case report and mini literature review
Li A, Li Y, Ge L, Li P, Li W
Drug Design, Development and Therapy 2017, 11:2373-2376
Published Date: 14 August 2017
Widening use of dexamethasone implant for the treatment of macular edema
Bonfiglio V, Reibaldi M, Fallico M, Russo A, Pizzo A, Fichera S, Rapisarda C, Macchi I, Avitabile T, Longo A
Drug Design, Development and Therapy 2017, 11:2359-2372
Published Date: 16 August 2017
Microbial challenge test of a novel epoprostenol sodium formulation
Bandilla D, Goverde M, Giudici P, Lambert O
Drug Design, Development and Therapy 2017, 11:2347-2357
Published Date: 10 August 2017
Isatin-benzoazine molecular hybrids as potential antiproliferative agents: synthesis and in vitro pharmacological profiling
Abdel-Aziz HA, Eldehna WM, Keeton AB, Piazza GA, Kadi AA, Attwa MW, Abdelhameed AS, Attia MI
Drug Design, Development and Therapy 2017, 11:2333-2346
Published Date: 9 August 2017
Anamorelin hydrochloride in the treatment of cancer anorexia–cachexia syndrome: design, development, and potential place in therapy
Graf SA, Garcia JM
Drug Design, Development and Therapy 2017, 11:2325-2331
Published Date: 7 August 2017
Modeling the human Nav1.5 sodium channel: structural and mechanistic insights of ion permeation and drug blockade
Ahmed M, Jalily Hasani H, Ganesan A, Houghton M, Barakat K
Drug Design, Development and Therapy 2017, 11:2301-2324
Published Date: 4 August 2017
Ambulatory blood pressure parameters after canrenone addition to existing treatment regimens with maximum tolerated dose of angiotensin-converting enzyme inhibitors/angiotensin II type 1 receptor blockers plus hydrochlorothiazide in uncontrolled hypertensive patients
Guasti L, Gaudio G, Lupi A, D'Avino M, Sala C, Mugellini A, Vulpis V, Felis S, Sarzani R, Vanasia M, Maffioli P, Derosa G
Drug Design, Development and Therapy 2017, 11:2293-2300
Published Date: 4 August 2017
Safety of switching from brand-name to generic levetiracetam in patients with epilepsy
Bosak M, Słowik A, Turaj W
Drug Design, Development and Therapy 2017, 11:2287-2291
Published Date: 3 August 2017
Efficacy and tolerability of two different formulations of atorvastatin in Korean patients with hypercholesterolemia: a multicenter, prospective, randomized clinical trial
Lee JH, Kim SH, Choi DJ, Tahk SJ, Yoon JH, Choi SW, Hong TJ, Kim HS
Drug Design, Development and Therapy 2017, 11:2277-2285
Published Date: 2 August 2017
Intracellular trafficking of new anticancer therapeutics: antibody–drug conjugates
Kalim M, Chen J, Wang S, Lin C, Ullah S, Liang K, Ding Q, Chen S, Zhan JB
Drug Design, Development and Therapy 2017, 11:2265-2276
Published Date: 2 August 2017
Markers of oxidative/nitrosative stress and inflammation in lung tissue of rats exposed to different intravenous iron compounds
Toblli JE, Cao G, Giani JF, Dominici FP, Angerosa M
Drug Design, Development and Therapy 2017, 11:2251-2263
Published Date: 1 August 2017
Combinatorial and sequential delivery of gemcitabine and oseltamivir phosphate from implantable poly(D,L-lactic-co-glycolic acid) cylinders disables human pancreatic cancer cell survival
Allison Logan S, Brissenden AJ, Szewczuk MR, Neufeld RJ
Drug Design, Development and Therapy 2017, 11:2239-2250
Published Date: 31 July 2017
Schiff base derived from thiosemicarbazone and anthracene showed high potential in overcoming multidrug resistance in vitro with low drug resistance index
Bai J, Wang RH, Qiao Y, Wang A, Fang CJ
Drug Design, Development and Therapy 2017, 11:2227-2237
Published Date: 31 July 2017
Comparative analysis of essential oil composition of Iranian and Indian Nigella sativa L. extracted using supercritical fluid extraction and solvent extraction
Ghahramanloo KH, Kamalidehghan B, Akbari Javar H, Teguh Widodo R, Majidzadeh K, Noordin MI
Drug Design, Development and Therapy 2017, 11:2221-2226
Published Date: 28 July 2017
Antibiotic susceptibility, heteroresistance, and updated treatment strategies in Helicobacter pylori infection
Mascellino MT, Porowska B, De Angelis M, Oliva A
Drug Design, Development and Therapy 2017, 11:2209-2220
Published Date: 28 July 2017
Comparison of efficacy and safety of oral agents for the treatment of relapsing–remitting multiple sclerosis
Guarnera C, Bramanti P, Mazzon E
Drug Design, Development and Therapy 2017, 11:2193-2207
Published Date: 28 July 2017
Schisandrin B attenuates CCl4-induced liver fibrosis in rats by regulation of Nrf2-ARE and TGF-β/Smad signaling pathways
Chen QS, Zhang H, Cao Y, Li Y, Sun S, Zhang JP, Zhang GQ
Drug Design, Development and Therapy 2017, 11:2179-2191
Published Date: 26 July 2017
The modulation of enzyme indoleamine 2,3-dioxygenase from dendritic cells for the treatment of type 1 diabetes mellitus
Abram DM, Fernandes LGR, Ramos Filho ACS, Simioni PU
Drug Design, Development and Therapy 2017, 11:2171-2178
Published Date: 24 July 2017
Using dezocine to prevent etomidate-induced myoclonus: a meta-analysis of randomized trials
Zhu Y, Yang Y, Zhou C, Bao Z
Drug Design, Development and Therapy 2017, 11:2163-2170
Published Date: 18 July 2017
Clinical utility of alpha-1 proteinase inhibitor in the management of adult patients with severe alpha-1 antitrypsin deficiency: a review of the current literature
Parr DG, Lara B
Drug Design, Development and Therapy 2017, 11:2149-2162
Published Date: 14 July 2017
Antiglycation, radical scavenging, and semicarbazide-sensitive amine oxidase inhibitory activities of acetohydroxamic acid in vitro
Liu YH, Lu YL, Liu DZ, Hou WC
Drug Design, Development and Therapy 2017, 11:2139-2147
Published Date: 13 July 2017
Efficacy and safety of direct-acting antiviral therapy in previous hard-to-treat patients with recurrent hepatitis C virus infection after liver transplantation: a real-world cohort
Bernuth S, Grimm D, Vollmar J, Darstein F, Mittler J, Heise M, Hoppe-Lotichius M, Galle PR, Lang H, Zimmermann T
Drug Design, Development and Therapy 2017, 11:2131-2138
Published Date: 12 July 2017
Clinical utility of evolocumab in the management of hyperlipidemia: patient selection and follow-up
Dixon DL, Buckley LF, Trankle CR, Kadariya D, Abbate A
Drug Design, Development and Therapy 2017, 11:2121-2129
Published Date: 11 July 2017
Bioequivalence of generic alendronate sodium tablets (70 mg) to Fosamax® tablets (70 mg) in fasting, healthy volunteers: a randomized, open-label, three-way, reference-replicated crossover study
Zhang Y, Chen X, Tang Y, Lu Y, Guo L, Zhong D
Drug Design, Development and Therapy 2017, 11:2109-2119
Published Date: 11 July 2017
A 6-month mixed-effect pharmacokinetic model for post-transplant intravenous anti-hepatitis B immunoglobulin prophylaxis
Han S, Na GH, Kim DG
Drug Design, Development and Therapy 2017, 11:2099-2107
Published Date: 11 July 2017
Evaluation of the stability of linezolid in aqueous solution and commonly used intravenous fluids
Taylor R, Sunderland B, Luna G, Czarniak P
Drug Design, Development and Therapy 2017, 11:2087-2097
Published Date: 10 July 2017
Pharmacokinetics, pharmacodynamics, and tolerability of verinurad, a selective uric acid reabsorption inhibitor, in healthy adult male subjects
Shen Z, Gillen M, Miner JN, Bucci G, Wilson DM, Hall JW
Drug Design, Development and Therapy 2017, 11:2077-2086
Published Date: 7 July 2017
Spotlight on brodalumab in the treatment of moderate-to-severe plaque psoriasis: design, development, and potential place in therapy
Roman M, Chiu MW
Drug Design, Development and Therapy 2017, 11:2065-2075
Published Date: 7 July 2017
Spotlight on ceritinib in the treatment of ALK+ NSCLC: design, development and place in therapy
Santarpia M, Daffinà MG, D'Aveni A, Marabello G, Liguori A, Giovannetti E, Karachaliou N, Gonzalez Cao M, Rosell R, Altavilla G
Drug Design, Development and Therapy 2017, 11:2047-2063
Published Date: 5 July 2017
Development of highly potent melanogenesis inhibitor by in vitro, in vivo and computational studies
Abbas Q, Ashraf Z, Hassan M, Nadeem H, Latif M, Afzal S, Seo S
Drug Design, Development and Therapy 2017, 11:2029-2046
Published Date: 5 July 2017
Synthesis and antimicrobial activity of chiral quaternary N-spiro ammonium bromides with 3',4'-dihydro-1'H-spiro[isoindoline-2,2'-isoquinoline] skeleton
Bielawski K, Leszczyńska K, Kałuża Z, Bielawska A, Michalak O, Daniluk T, Staszewska-Krajewska O, Czajkowska A, Pawłowska N, Gornowicz A
Drug Design, Development and Therapy 2017, 11:2015-2028
Published Date: 5 July 2017
Inhibitors of the PD-1/PD-L1 axis for the treatment of head and neck cancer: current status and future perspectives
Ran X, Yang K
Drug Design, Development and Therapy 2017, 11:2007-2014
Published Date: 3 July 2017
Salidroside pretreatment attenuates apoptosis and autophagy during hepatic ischemia–reperfusion injury by inhibiting the mitogen-activated protein kinase pathway in mice
Feng J, Zhang Q, Mo WH, Wu L, Li S, Li J, Liu T, Xu S, Fan X, Guo C
Drug Design, Development and Therapy 2017, 11:1989-2006
Published Date: 3 July 2017
Targeted therapy in severe asthma today: focus on immunoglobulin E
Pelaia G, Canonica GW, Matucci A, Paolini R, Triggiani M, Paggiaro P
Drug Design, Development and Therapy 2017, 11:1979-1987
Published Date: 29 June 2017
A review of the literature analyzing benefits and concerns of infliximab biosimilar CT-P13 for the treatment of rheumatologic diseases: focus on interchangeability
Becciolini A, Raimondo MG, Crotti C, Agape E, Biggioggero M, Favalli EG
Drug Design, Development and Therapy 2017, 11:1969-1978
Published Date: 28 June 2017
Cell and small animal models for phenotypic drug discovery
Szabo M, Svensson Akusjärvi S, Saxena A, Liu J, Chandrasekar G, Kitambi SS
Drug Design, Development and Therapy 2017, 11:1957-1967
Published Date: 28 June 2017
Determining optimal dosing regimen of oral administration of dicloxacillin using Monte Carlo simulation
Yu W, Ji J, Xiao T, Ying C, Fang J, Shen P, Xiao Y
Drug Design, Development and Therapy 2017, 11:1951-1956
Published Date: 28 June 2017
A novel local anesthetic system: transcriptional transactivator peptide-decorated nanocarriers for skin delivery of ropivacaine
Chen CY, You PJ
Drug Design, Development and Therapy 2017, 11:1941-1949
Published Date: 28 June 2017
Comparison of neurotoxic potency between a novel chinbotulinumtoxinA with onabotulinumtoxinA, incobotulinumtoxinA and lanbotulinumtoxinA in rats
Feng Y, Liu WC, Pan LZ, Jiang C, Zhang CX, Lu YX, Nie ZY, Jin LJ
Drug Design, Development and Therapy 2017, 11:1927-1939
Published Date: 28 June 2017
Effect of picroside II on hind limb ischemia reperfusion injury in rats
Kılıç Y, Özer A, Tatar T, Zor MH, Kirişçi M, Kartal H, Dursun AD, Billur D, Arslan M, Küçük A
Drug Design, Development and Therapy 2017, 11:1917-1925
Published Date: 26 June 2017
Antiglioma effects of cytarabine on leptomeningeal metastasis of high-grade glioma by targeting the PI3K/Akt/mTOR pathway
Zhao KH, Zhang C, Bai Y, Li Y, Kang X, Chen JX, Yao K, Jiang T, Zhong XS, Li WB
Drug Design, Development and Therapy 2017, 11:1905-1915
Published Date: 26 June 2017
Synthesis and cytotoxic activities of novel 4-methoxy-substituted and 5-methyl-substituted (3′S,4′S)-(-)-cis-khellactone derivatives that induce apoptosis via the intrinsic pathway
Chen JR, Liu JJ, Cui DX, Yan CQ, Meng LQ, Sun LQ, Ban SR, Ge R, Liang TG, Li QS
Drug Design, Development and Therapy 2017, 11:1891-1904
Published Date: 23 June 2017
Total flavonoids from Rhizoma Drynariae (Gusuibu) for treating osteoporotic fractures: implication in clinical practice
Zhang YL, Jiang JJ, Shen H, Chai Y, Wei X, Xie YM
Drug Design, Development and Therapy 2017, 11:1881-1890
Published Date: 23 June 2017
Efficacy and safety of retinol palmitate ophthalmic solution in the treatment of dry eye: a Japanese Phase II clinical trial
Toshida H, Funaki T, Ono K, Tabuchi N, Watanabe S, Seki T, Otake H, Kato T, Ebihara N, Murakami A
Drug Design, Development and Therapy 2017, 11:1871-1879
Published Date: 23 June 2017
Molecular docking, QSAR and ADMET studies of withanolide analogs against breast cancer
Yadav DK, Kumar S, Saloni, Singh H, Kim M, Sharma P, Misra S, Khan F
Drug Design, Development and Therapy 2017, 11:1859-1870
Published Date: 22 June 2017
Differential effect of platelet-rich plasma fractions on β1-integrin signaling, collagen biosynthesis, and prolidase activity in human skin fibroblasts
Guszczyn T, Surażyński A, Zaręba I, Rysiak E, Popko J, Pałka J
Drug Design, Development and Therapy 2017, 11:1849-1857
Published Date: 22 June 2017
Enzymatic synthesis and in vitro evaluation of folate-functionalized liposomes
Guo B, Xu D, Liu X, Yi J
Drug Design, Development and Therapy 2017, 11:1839-1847
Published Date: 20 June 2017
Comparison of posttransplant outcomes in patients with no, acute, or chronic amiodarone use before heart transplantation
Rivinius R, Helmschrott M, Ruhparwar A, Darche FF, Thomas D, Bruckner T, Katus HA, Doesch AO
Drug Design, Development and Therapy 2017, 11:1827-1837
Published Date: 19 June 2017
Intranasal agomelatine solid lipid nanoparticles to enhance brain delivery: formulation, optimization and in vivo pharmacokinetics
Fatouh AM, Elshafeey AH, Abdelbary A
Drug Design, Development and Therapy 2017, 11:1815-1825
Published Date: 19 June 2017
Virtual screening for potential inhibitors of Mcl-1 conformations sampled by normal modes, molecular dynamics, and nuclear magnetic resonance
Glantz-Gashai Y, Meirson T, Reuveni E, Samson AO
Drug Design, Development and Therapy 2017, 11:1803-1813
Published Date: 19 June 2017
Morusin shows potent antitumor activity for human hepatocellular carcinoma in vitro and in vivo through apoptosis induction and angiogenesis inhibition
Gao L, Wang L, Sun Z, Li H, Wang Q, Yi C, Wang X
Drug Design, Development and Therapy 2017, 11:1789-1802
Published Date: 16 June 2017
Historical development of vaginal microbicides to prevent sexual transmission of HIV in women: from past failures to future hopes
Notario-Pérez F, Ruiz-Caro R, Veiga-Ochoa MD
Drug Design, Development and Therapy 2017, 11:1767-1787
Published Date: 15 June 2017
Cryptotanshinone induces cell cycle arrest and apoptosis through the JAK2/STAT3 and PI3K/Akt/NFkB pathways in cholangiocarcinoma cells
Ke FY, Wang Z, Song XL, Ma Q, Hu YP, Jiang L, Zhang YJ, Liu YB, Zhang Y, Gong W
Drug Design, Development and Therapy 2017, 11:1753-1766
Published Date: 15 June 2017
Controlled release of optimized electroporation enhances the transdermal efficiency of sinomenine hydrochloride for treating arthritis in vitro and in clinic
Feng S, Zhu L, Huang Z, Wang H, Li H, Zhou H, Lu L, Wang Y, Liu Z, Liu L
Drug Design, Development and Therapy 2017, 11:1737-1752
Published Date: 15 June 2017
Efficacy of antibiotic treatment of implant-associated Staphylococcus aureus infections with moxifloxacin, flucloxacillin, rifampin, and combination therapy: an animal study
Greimel F, Scheuerer C, Gessner A, Simon M, Kalteis T, Grifka J, Benditz A, Springorum HR, Schaumburger J
Drug Design, Development and Therapy 2017, 11:1729-1736
Published Date: 14 June 2017
Lugano 2014 criteria for assessing FDG-PET/CT in lymphoma: an operational approach for clinical trials
Van Heertum RL, Scarimbolo R, Wolodzko JG, Klencke B, Messmann R, Tunc F, Sokol L, Agarwal R, Strafaci JA, O'Neal M
Drug Design, Development and Therapy 2017, 11:1719-1728
Published Date: 13 June 2017
Controlled-release nanoencapsulating microcapsules to combat inflammatory diseases
Baek JS, Yeo EW, Lee YH, Tan NS, Loo SCJ
Drug Design, Development and Therapy 2017, 11:1707-1717
Published Date: 8 June 2017
Development of new promising antimetabolite, DFP-11207 with self-controlled toxicity in rodents
Fukushima M, Iizuka K, Jin C, Zhang C, Hong M, Eshima K
Drug Design, Development and Therapy 2017, 11:1693-1705
Published Date: 7 June 2017
Experimental, molecular docking investigations and bioavailability study on the inclusion complexes of finasteride and cyclodextrins
Mady FM, Farghaly Aly U
Drug Design, Development and Therapy 2017, 11:1681-1692
Published Date: 7 June 2017
Renal function in heart transplant patients after switch to combined mammalian target of rapamycin inhibitor and calcineurin inhibitor therapy
Helmschrott M, Rivinius R, Bruckner T, Katus HA, Doesch AO
Drug Design, Development and Therapy 2017, 11:1673-1680
Published Date: 7 June 2017
Rhein attenuates inflammation through inhibition of NF-κB and NALP3 inflammasome in vivo and in vitro
Ge H, Tang H, Liang Y, Wu J, Yang Q, Zeng L, Ma Z
Drug Design, Development and Therapy 2017, 11:1663-1671
Published Date: 6 June 2017
CT-P13: design, development, and place in therapy
Gabbani T, Deiana S, Annese V
Drug Design, Development and Therapy 2017, 11:1653-1661
Published Date: 6 June 2017
Spotlight on ixekizumab for the treatment of moderate-to-severe plaque psoriasis: design, development, and use in therapy
Giunta A, Ventura A, Chimenti MS, Bianchi L, Esposito M
Drug Design, Development and Therapy 2017, 11:1643-1651
Published Date: 2 June 2017
p-TSA-promoted syntheses of 5H-benzo[h]thiazolo[2,3-b]quinazoline and indeno[1,2-d]thiazolo[3,2-a]pyrimidine analogs: molecular modeling and in vitro antitumor activity against hepatocellular carcinoma
Keshari AK, Singh AK, Raj V, Rai A, Trivedi P, Ghosh B, Kumar U, Rawat A, Kumar D, Saha S
Drug Design, Development and Therapy 2017, 11:1623-1642
Published Date: 29 May 2017
Development of antiproliferative long-circulating liposomes co-encapsulating doxorubicin and curcumin, through the use of a quality-by-design approach
Tefas LR, Sylvester B, Tomuta I, Sesarman A, Licarete E, Banciu M, Porfire A
Drug Design, Development and Therapy 2017, 11:1605-1621
Published Date: 25 May 2017
Profile of sarilumab and its potential in the treatment of rheumatoid arthritis
Raimondo MG, Biggioggero M, Crotti C, Becciolini A, Favalli EG
Drug Design, Development and Therapy 2017, 11:1593-1603
Published Date: 24 May 2017
Effect of a food supplement containing berberine, monacolin K, hydroxytyrosol and coenzyme Q10 on lipid levels: a randomized, double-blind, placebo controlled study
D'Addato S, Scandiani L, Mombelli G, Focanti F, Pelacchi F, Salvatori E, Di Loreto G, Comandini A, Maffioli P, Derosa G
Drug Design, Development and Therapy 2017, 11:1585-1592
Published Date: 23 May 2017
Past and current perspective on new therapeutic targets for Type-II diabetes
Patil PD, Mahajan UB, Patil KR, Chaudhari S, Patil CR, Agrawal YO, Ojha S, Goyal SN
Drug Design, Development and Therapy 2017, 11:1567-1583
Published Date: 22 May 2017
Outcome of stroke patients receiving different doses of recombinant tissue plasminogen activator
Ong CT, Wong YS, Wu CS, Su YH
Drug Design, Development and Therapy 2017, 11:1559-1566
Published Date: 18 May 2017
An in silico high-throughput screen identifies potential selective inhibitors for the non-receptor tyrosine kinase Pyk2
Meirson T, Samson AO, Gil-Henn H
Drug Design, Development and Therapy 2017, 11:1535-1557
Published Date: 18 May 2017
Cisplatin induces protective autophagy through activation of BECN1 in human bladder cancer cells
Lin JF, Lin YC, Tsai TF, Chen HE, Chou KY, Hwang TIS
Drug Design, Development and Therapy 2017, 11:1517-1533
Published Date: 16 May 2017
Ten years of biosimilars in Europe: development and evolution of the regulatory pathways
Schiestl M, Zabransky M, Sörgel F
Drug Design, Development and Therapy 2017, 11:1509-1515
Published Date: 16 May 2017
Ten years of biosimilar recombinant human growth hormone in Europe
Saenger P
Drug Design, Development and Therapy 2017, 11:1505-1507
Published Date: 16 May 2017
Ten years of clinical experience with biosimilar human growth hormone: a review of safety data
Borrás Pérez MV, Kriström B, Romer T, Walczak M, Höbel N, Zabransky M
Drug Design, Development and Therapy 2017, 11:1497-1503
Published Date: 16 May 2017
Ten years' clinical experience with biosimilar human growth hormone: a review of efficacy data
López-Siguero JP, Pfäffle R, Chanson P, Szalecki M, Höbel N, Zabransky M
Drug Design, Development and Therapy 2017, 11:1489-1495
Published Date: 16 May 2017
Effects of metformin extended release compared to immediate release formula on glycemic control and glycemic variability in patients with type 2 diabetes
Derosa G, D'Angelo A, Romano D, Maffioli P
Drug Design, Development and Therapy 2017, 11:1481-1488
Published Date: 16 May 2017
Spotlight on dupilumab in the treatment of atopic dermatitis: design, development, and potential place in therapy
D’Erme AM, Romanelli M, Chiricozzi A
Drug Design, Development and Therapy 2017, 11:1473-1480
Published Date: 15 May 2017
Higher dose of palonosetron versus lower dose of palonosetron plus droperidol to prevent postoperative nausea and vomiting after eye enucleation and orbital hydroxyapatite implant surgery: a randomized, double-blind trial
Hu X, Tan F, Gong L
Drug Design, Development and Therapy 2017, 11:1465-1472
Published Date: 15 May 2017
Fabrication, characterization and in vitro evaluation of silibinin nanoparticles: an attempt to enhance its oral bioavailability
Sahibzada MUK, Sadiq A, Khan S, Faidah HS, Naseemullah, Khurram M, Amin MU, Haseeb A
Drug Design, Development and Therapy 2017, 11:1453-1464
Published Date: 15 May 2017
Design, synthesis, and biological evaluation of novel EF24 and EF31 analogs as potential IκB kinase β inhibitors for the treatment of pancreatic cancer
Xie X, Tu J, You H, Hu B
Drug Design, Development and Therapy 2017, 11:1439-1451
Published Date: 12 May 2017
New developments in managing opioid addiction: impact of a subdermal buprenorphine implant
Itzoe M, Guarnieri M
Drug Design, Development and Therapy 2017, 11:1429-1437
Published Date: 10 May 2017
Preparation, characterization, and in vitro/vivo studies of oleanolic acid-loaded lactoferrin nanoparticles
Xia X, Liu H, Lv H, Zhang J, Zhou JP, Zhao Z
Drug Design, Development and Therapy 2017, 11:1417-1427
Published Date: 9 May 2017
Effect of epigallocatechin-3-gallate, major ingredient of green tea, on the pharmacokinetics of rosuvastatin in healthy volunteers
Kim TE, Ha N, Kim Y, Kim H, Lee JW, Jeon JY, Kim MG
Drug Design, Development and Therapy 2017, 11:1409-1416
Published Date: 9 May 2017
Propranolol therapy for infantile hemangioma: our experience
Zhang L, Wu HW, Yuan W, Zheng J
Drug Design, Development and Therapy 2017, 11:1401-1408
Published Date: 8 May 2017
Involvement of NF-κB and HSP70 signaling pathways in the apoptosis of MDA-MB-231 cells induced by a prenylated xanthone compound, α-mangostin, from Cratoxylum arborescens [Retraction]
Ibrahim MY, Hashim NM, Mohan S, Abdulla MA, Abdelwahab SI, Kamalidehghan B, Ghaderian M, Dehghan F, Ali LZ, Karimian H, Yahayu M, Ee GCL, Farjam AS, Ali HM
Drug Design, Development and Therapy 2017, 11:1399-1400
Published Date: 12 May 2017
Effect of electromagnetic fields and antioxidants on the trace element content of rat teeth
Dogan MS, Yavas MC, Yavuz Y, Erdogan S, Yener İ, Simsek İ, Akkus Z, Eratilla V, Tanik A, Akdag MZ
Drug Design, Development and Therapy 2017, 11:1393-1398
Published Date: 4 May 2017
Atorvastatin, a double weapon in osteoporosis treatment: an experimental and clinical study
El-Nabarawy N, El-Wakd M, Salem M
Drug Design, Development and Therapy 2017, 11:1383-1391
Published Date: 2 May 2017
Developing selective histone deacetylases (HDACs) inhibitors through ebselen and analogs
Wang Y, Wallach J, Duane S, Wang Y, Wu J, Wang J, Adejare A, Ma H
Drug Design, Development and Therapy 2017, 11:1369-1382
Published Date: 2 May 2017
Combined letrozole and clomiphene versus letrozole and clomiphene alone in infertile patients with polycystic ovary syndrome [Erratum]
Ghasemi-Rad M, Hajishafiha M, Dehghan M, Sadegh-Asadi N, Navid Shayegh S, Kiarang N
Drug Design, Development and Therapy 2017, 11:1367-1368
Published Date: 28 April 2017
Methanol leaf extract of Actinodaphne sesquipedalis (Lauraceae) enhances gastric defense against ethanol-induced ulcer in rats
Omar H, Nordin N, Hassandarvish P, Hajrezaie M, Azizan AHS, Fadaeinasab M, Abdul Majid N, Abdulla MA, Mohd Hashim N, Mohd Ali H
Drug Design, Development and Therapy 2017, 11:1353-1365
Published Date: 4 May 2017
Evaluation of the antitumor activity of NOV202, a novel microtubule targeting and vascular disrupting agent
Rickardson L, Kutvonen E, Orasniemi S, Högberg M, Kallio MJ, Rehnmark S
Drug Design, Development and Therapy 2017, 11:1335-1351
Published Date: 28 April 2017
Development and evaluation of a new modular nanotransporter for drug delivery into nuclei of pathological cells expressing folate receptors
Slastnikova TA, Rosenkranz AA, Khramtsov YV, Karyagina TS, Ovechko SA, Sobolev AS
Drug Design, Development and Therapy 2017, 11:1315-1334
Published Date: 26 April 2017
A first-in-human, double-blind, placebo-controlled, randomized, dose escalation study of DWP05195, a novel TRPV1 antagonist, in healthy volunteers
Lee J, Kim BH, Yu KS, Kim HS, Kim JD, Cho JY, Lee S, Gu N
Drug Design, Development and Therapy 2017, 11:1301-1313
Published Date: 24 April 2017
Proton-pump inhibitors use, and risk of acute kidney injury: a meta-analysis of observational studies
Yang Y, George KC, Shang WF, Zeng R, Ge SW, Xu G
Drug Design, Development and Therapy 2017, 11:1291-1299
Published Date: 24 April 2017
Functional characterization of wild-type and 24 CYP2D6 allelic variants on gefitinib metabolism in vitro
Fang P, Zheng X, He JY, Ge HL, Tang PF, Cai JP, Hu GX
Drug Design, Development and Therapy 2017, 11:1283-1290
Published Date: 21 April 2017
Cerebrolysin for functional recovery in patients with acute ischemic stroke: a meta-analysis of randomized controlled trials
Wang ZF, Shi LG, Xu SB, Zhang JM
Drug Design, Development and Therapy 2017, 11:1273-1282
Published Date: 19 April 2017
Anti-platelet effects of anti-glaucomatous eye drops: an in vitro study on human platelets
Moschos MM, Moustafa GA, Papakonstantinou VD, Tsatsos M, Laios K, Antonopoulou S
Drug Design, Development and Therapy 2017, 11:1267-1272
Published Date: 19 April 2017
Pharmacokinetic interactions between glimepiride and rosuvastatin in healthy Korean subjects: does the SLCO1B1 or CYP2C9 genetic polymorphism affect these drug interactions? Observations and introspection of the bioanalysis
Thakkar D, Dash RP
Drug Design, Development and Therapy 2017, 11:1263-1265
Published Date: 20 April 2017
Detection approaches for multidrug resistance genes of leukemia
Du Y, Chen B
Drug Design, Development and Therapy 2017, 11:1255-1261
Published Date: 18 April 2017
Humanin rescues cultured rat cortical neurons from NMDA-induced toxicity through the alleviation of mitochondrial dysfunction
Cui A, Zhang Y, Li J, Song T, Liu X, Wang H, Zhang C, Ma G, Zhang H, Li K
Drug Design, Development and Therapy 2017, 11:1243-1253
Published Date: 18 April 2017
A comparative study on endovascular treatment of (sub)acute critical limb ischemia: mechanical thrombectomy vs thrombolysis
Kronlage M, Printz I, Vogel B, Blessing E, Müller OJ, Katus HA, Erbel C
Drug Design, Development and Therapy 2017, 11:1233-1241
Published Date: 18 April 2017
Profile of romosozumab and its potential in the management of osteoporosis
Lim SY, Bolster MB
Drug Design, Development and Therapy 2017, 11:1221-1231
Published Date: 13 April 2017
United States experience of insulin Degludec alone or in combination for type 1 and type 2 diabetes
Rendell M
Drug Design, Development and Therapy 2017, 11:1209-1220
Published Date: 13 April 2017
Riociguat: a soluble guanylate cyclase stimulator for the treatment of pulmonary hypertension
Lian TY, Jiang X, Jing ZC
Drug Design, Development and Therapy 2017, 11:1195-1207
Published Date: 13 April 2017
Vitamin D deficiency and tuberculosis: what about body mass index?
Hernández-Garduño E
Drug Design, Development and Therapy 2017, 11:1193-1194
Published Date: 11 April 2017
Bioequivalence study of a new sildenafil 100 mg orodispersible film compared to the conventional film-coated 100 mg tablet administered to healthy male volunteers
Radicioni M, Castiglioni C, Giori A, Cupone I, Frangione V, Rovati S
Drug Design, Development and Therapy 2017, 11:1183-1192
Published Date: 11 April 2017
Spotlight on nivolumab in the treatment of renal cell carcinoma: design, development, and place in therapy
Venur VA, Joshi M, Nepple KG, Zakharia Y
Drug Design, Development and Therapy 2017, 11:1175-1182
Published Date: 11 April 2017
Justification of disintegration testing beyond current FDA criteria using in vitro and in silico models
Uebbing L, Klumpp L, Webster GK, Löbenberg R
Drug Design, Development and Therapy 2017, 11:1163-1174
Published Date: 11 April 2017
Decitabine reverses TGF-β1-induced epithelial–mesenchymal transition in non-small-cell lung cancer by regulating miR-200/ZEB axis [Corrigendum]
Zhang N, Liu Y, Wang Y, Zhao M, Tu L, Luo F
Drug Design, Development and Therapy 2017, 11:1161-1162
Published Date: 10 April 2017
Relaxin inhibits cardiac fibrosis and endothelial–mesenchymal transition via the Notch pathway [Corrigendum]
Zhou X, Chen X, Cai JJ, Chen LZ, Gong YS, Wang LX, Gao Z, Zhang HQ, Huang WJ, Zhou H
Drug Design, Development and Therapy 2017, 11:1159-1160
Published Date: 10 April 2017
Inhibition of lymphangiogenesis in vitro and in vivo by the multikinase inhibitor nintedanib
Lin T, Gong L
Drug Design, Development and Therapy 2017, 11:1147-1158
Published Date: 5 April 2017
Association of genetic variations with pharmacokinetics and lipid-lowering response to atorvastatin in healthy Korean subjects
Woo HI, Kim SR, Huh W, Ko JW, Lee SY
Drug Design, Development and Therapy 2017, 11:1135-1146
Published Date: 4 April 2017
Investigation of triamterene as an inhibitor of the TGR5 receptor: identification in cells and animals
Li Y, Cheng KC, Niu C, Lo S, Cheng JT, Niu H
Drug Design, Development and Therapy 2017, 11:1127-1134
Published Date: 5 April 2017
Efficacy of the dual PI3K and mTOR inhibitor NVP-BEZ235 in combination with imatinib mesylate against chronic myelogenous leukemia cell lines
Xin P, Li C, Zheng Y, Peng Q, Xiao H, Huang Y, Zhu X
Drug Design, Development and Therapy 2017, 11:1115-1126
Published Date: 3 April 2017
Effects of intrathecal dexmedetomidine on shivering after spinal anesthesia for cesarean section: a double-blind randomized clinical trial
Nasseri K, Ghadami N, Nouri B
Drug Design, Development and Therapy 2017, 11:1107-1113
Published Date: 3 April 2017
Phenotypic evaluation and in silico ADMET properties of novel arylimidamides in acute mouse models of Trypanosoma cruzi infection
da Silva CF, Batista DDGJ, de Araújo JS, Cunha-Junior EF, Stephens CE, Banerjee M, Farahat AA, Akay S, Fisher MK, Boykin DW, Soeiro MDNC
Drug Design, Development and Therapy 2017, 11:1095-1105
Published Date: 3 April 2017
Formulation, release characteristics, and bioavailability study of gastroretentive floating matrix tablet and floating raft system of Mebeverine HCl
El Nabarawi MA, Teaima MH, Abd El-Monem RA, El Nabarawy NA, Gaber DA
Drug Design, Development and Therapy 2017, 11:1081-1093
Published Date: 3 April 2017
Effect of berberine on the renal tubular epithelial-to-mesenchymal transition by inhibition of the Notch/snail pathway in diabetic nephropathy model KKAy mice
Yang GN, Zhao ZJ, Zhang XX, Wu AM, Huang YW, Miao YH, Yang MJ
Drug Design, Development and Therapy 2017, 11:1065-1079
Published Date: 31 March 2017
Spotlight on romiplostim in the treatment of children with chronic immune thrombocytopenia: design, development, and potential place in therapy
Buchbinder D, Nugent D, Hsieh L
Drug Design, Development and Therapy 2017, 11:1055-1063
Published Date: 30 March 2017
Drug–drug interaction of microdose and regular-dose omeprazole with a CYP2C19 inhibitor and inducer
Park G, Bae SH, Park W, Han S, Park M, Shin S, Shin YG, Yim DS
Drug Design, Development and Therapy 2017, 11:1043-1053
Published Date: 30 March 2017
Mirtazapine for symptom control in refractory gastroparesis
Malamood M, Roberts A, Kataria R, Parkman HP, Schey R
Drug Design, Development and Therapy 2017, 11:1035-1041
Published Date: 30 March 2017
Effects of β-D-mannuronic acid, as a novel non-steroidal anti-inflammatory medication within immunosuppressive properties, on IL17, RORγt, IL4 and GATA3 gene expressions in rheumatoid arthritis patients
Barati A, Jamshidi AR, Ahmadi H, Aghazadeh Z, Mirshafiey A
Drug Design, Development and Therapy 2017, 11:1027-1033
Published Date: 30 March 2017
Rutin protects against neuronal damage in vitro and ameliorates doxorubicin-induced memory deficits in vivo in Wistar rats
Ramalingayya GV, Cheruku SP, Nayak PG, Kishore A, Shenoy R, Rao CM, Krishnadas N
Drug Design, Development and Therapy 2017, 11:1011-1026
Published Date: 29 March 2017
The antiulcer effect of Cibotium barometz leaves in rats with experimentally induced acute gastric ulcer
AL-Wajeeh NS, Hajrezaei M, Al-Henhena N, Kamran S, Bagheri E, Zahedifard M, Saremi K, Noor SM, Ali HM, Abdulla MA
Drug Design, Development and Therapy 2017, 11:995-1009
Published Date: 30 March 2017
An open randomized active-controlled clinical trial with low-dose SKA cytokines versus DMARDs evaluating low disease activity maintenance in patients with rheumatoid arthritis
Martin-Martin LS, Giovannangeli F, Bizzi E, Massafra U, Ballanti E, Cassol M, Migliore A
Drug Design, Development and Therapy 2017, 11:985-994
Published Date: 29 March 2017
Decitabine reverses TGF-β1-induced epithelial–mesenchymal transition in non-small-cell lung cancer by regulating miR-200/ZEB axis
Zhang N, Liu Y, Wang Y, Zhao M, Tu L, Luo F
Drug Design, Development and Therapy 2017, 11:969-983
Published Date: 28 March 2017
Optimized formulation of multivesicular liposomes loaded with oleanolic acid enhanced anticancer effect in vitro
Wang Y, Luo Y, Li C, Zhang X, Pi C, Yu L, Wang S, Zhong Z
Drug Design, Development and Therapy 2017, 11:955-968
Published Date: 27 March 2017
Differential clinical pharmacology of rolapitant in delayed chemotherapy-induced nausea and vomiting (CINV)
Rashad N, Abdel-Rahman O
Drug Design, Development and Therapy 2017, 11:947-954
Published Date: 24 March 2017
Synergistic effects of antimicrobial peptide DP7 combined with antibiotics against multidrug-resistant bacteria
Wu X, Li Z, Li X, Tian Y, Fan Y, Yu C, Zhou B, Liu Y, Xiang R, Yang L
Drug Design, Development and Therapy 2017, 11:939-946
Published Date: 22 March 2017
Sodium-glucose cotransporter 2 inhibitors combined with dipeptidyl peptidase-4 inhibitors in the management of type 2 diabetes: a review of current clinical evidence and rationale
Yassin SA, Aroda VR
Drug Design, Development and Therapy 2017, 11:923-937
Published Date: 21 March 2017
Nanostructured lipid carriers for incorporation of copper(II) complexes to be used against Mycobacterium tuberculosis
Sato MR, Oshiro Junior JA, Machado RTA, de Souza PC, Campos DL, Pavan FR, da Silva PB, Chorilli M
Drug Design, Development and Therapy 2017, 11:909-921
Published Date: 20 March 2017
Synergistic protective effect of N-acetylcysteine and taurine against cisplatin-induced nephrotoxicity in rats
Abdel-Wahab WM, Moussa FI, Saad NA
Drug Design, Development and Therapy 2017, 11:901-908
Published Date: 20 March 2017
Clinical potential of SLAMF7 antibodies – focus on elotuzumab in multiple myeloma
Friend R, Bhutani M, Voorhees PM, Usmani SZ
Drug Design, Development and Therapy 2017, 11:893-900
Published Date: 20 March 2017
Delafloxacin: design, development and potential place in therapy
Candel FJ, Peñuelas M
Drug Design, Development and Therapy 2017, 11:881-891
Published Date: 20 March 2017
Artonin E induces p53-independent G1 cell cycle arrest and apoptosis through ROS-mediated mitochondrial pathway and livin suppression in MCF-7 cells
Etti IC, Rasedee A, Hashim NM, Abdul AB, Kadir A, Yeap SK, Waziri P, Malami I, Lim KL, Etti CJ
Drug Design, Development and Therapy 2017, 11:865-879
Published Date: 20 March 2017
Efficacy of cytokine-induced killer cell infusion as an adjuvant immunotherapy for hepatocellular carcinoma: a systematic review and meta-analysis
Yu R, Yang B, Chi X, Cai L, Liu C, Yang L, Wang X, He P, Lu X
Drug Design, Development and Therapy 2017, 11:851-864
Published Date: 17 March 2017
Cardioprotection with halogenated gases: how does it occur?
Guerrero-Orriach JL, Escalona Belmonte JJ, Ramirez Fernandez A, Ramirez Aliaga M, Rubio Navarro M, Cruz Mañas J
Drug Design, Development and Therapy 2017, 11:837-849
Published Date: 16 March 2017
Design, synthesis, and antimelanogenic effects of (2-substituted phenyl-1,3-dithiolan-4-yl)methanol derivatives
Kim DH, Kim SJ, Ullah S, Yun HY, Chun P, Moon HR
Drug Design, Development and Therapy 2017, 11:827-836
Published Date: 16 March 2017
Fixed-dose combination orally disintegrating tablets to treat cardiovascular disease: formulation, in vitro characterization and physiologically based pharmacokinetic modeling to assess bioavailability
Dennison TJ, Smith JC, Badhan RK, Mohammed AR
Drug Design, Development and Therapy 2017, 11:811-826
Published Date: 16 March 2017
Proteinopathy, oxidative stress and mitochondrial dysfunction: cross talk in Alzheimer's disease and Parkinson's disease
Ganguly G, Chakrabarti S, Chatterjee U, Saso L
Drug Design, Development and Therapy 2017, 11:797-810
Published Date: 16 March 2017
HMGB1 siRNA can reduce damage to retinal cells induced by high glucose in vitro and in vivo
Jiang S, Chen X
Drug Design, Development and Therapy 2017, 11:783-795
Published Date: 15 March 2017
Development of erythropoietin receptor-targeted drug delivery system against breast cancer using tamoxifen-loaded nanostructured lipid carriers
Beh CY, How CW, Foo JB, Foong JN, Selvarajah GT, Rasedee A
Drug Design, Development and Therapy 2017, 11:771-782
Published Date: 14 March 2017
Glycophenotype of breast and prostate cancer stem cells treated with thieno[2,3-b]pyridine anticancer compound
Mastelić A, Čikeš Čulić V, Režić Mužinić N, Vuica-Ross M, Barker D, Leung EY, Reynisson J, Markotić A
Drug Design, Development and Therapy 2017, 11:759-769
Published Date: 14 March 2017
Spotlight on blisibimod and its potential in the treatment of systemic lupus erythematosus: evidence to date
Lenert A, Niewold TB, Lenert P
Drug Design, Development and Therapy 2017, 11:747-757
Published Date: 13 March 2017
Risk assessment and experimental design in the development of a prolonged release drug delivery system with paliperidone
Iurian S, Turdean L, Tomuta I
Drug Design, Development and Therapy 2017, 11:733-746
Published Date: 13 March 2017
An open-label, two-period comparative study on pharmacokinetics and safety of a combined ethinylestradiol/gestodene transdermal contraceptive patch
Zhang C, Li H, Xiong X, Zhai S, Wei Y, Zhang S, Zhang Y, Xu L, Liu L
Drug Design, Development and Therapy 2017, 11:725-731
Published Date: 10 March 2017
Pharmacokinetics and tolerability of DA-8031, a novel selective serotonin reuptake inhibitor for premature ejaculation in healthy male subjects
Shin D, Lee S, Yi S, Yoon SH, Cho JY, Bahng MY, Jang IJ, Yu KS
Drug Design, Development and Therapy 2017, 11:713-723
Published Date: 10 March 2017
Effects of dexamethasone coadministered with oseltamivir on the pharmacokinetics of oseltamivir in healthy volunteers
Jang K, Kim M, Oh J, Lee S, Cho JY, Yu KS, Choi TK, Lee SH, Lim KS
Drug Design, Development and Therapy 2017, 11:705-711
Published Date: 9 March 2017
Transcriptome analysis of endometrial tissues following GnRH agonist treatment in a mouse adenomyosis model
Guo S, Lu X, Gu R, Zhang D, Sun Y, Feng Y
Drug Design, Development and Therapy 2017, 11:695-704
Published Date: 9 March 2017
Development of venetoclax for therapy of lymphoid malignancies
Zhu H, Almasan A
Drug Design, Development and Therapy 2017, 11:685-694
Published Date: 9 March 2017
Does remifentanil attenuate renal ischemia–reperfusion injury better than dexmedetomidine in rat kidney?
Erkılıç E, Kesimci E, Alaybeyoğlu F, Kılınç I, Tural R, Yazgan A, Gümüş T, Sepici Dinçel A, Dumlu EG, Kanbak O
Drug Design, Development and Therapy 2017, 11:677-683
Published Date: 8 March 2017
Protective influence of hyaluronic acid on focal adhesion kinase activity in human skin fibroblasts exposed to ethanol
Donejko M, Rysiak E, Galicka E, Terlikowski R, Głażewska EK, Przylipiak A
Drug Design, Development and Therapy 2017, 11:669-676
Published Date: 6 March 2017
Paclitaxel-loaded star-shaped copolymer nanoparticles for enhanced malignant melanoma chemotherapy against multidrug resistance
Su Y, Hu J, Huang Z, Huang Y, Peng B, Xie N, Liu H
Drug Design, Development and Therapy 2017, 11:659-668
Published Date: 6 March 2017
New developments in the management of partial-onset epilepsy: role of brivaracetam
Coppola G, Iapadre G, Operto FF, Verrotti A
Drug Design, Development and Therapy 2017, 11:643-657
Published Date: 6 March 2017
MC-PPEA as a new and more potent inhibitor of CLP-induced sepsis and pulmonary inflammation than FK866
Huang P, Lee Jr MW, Sadrerafi K, Heruth DP, Zhang LQ, Maulik D, Ye SQ
Drug Design, Development and Therapy 2017, 11:629-641
Published Date: 3 March 2017
β3-Adrenoceptor activation upregulates apolipoprotein A-I expression in HepG2 cells, which might further promote cholesterol efflux from macrophage foam cells
Gao XQ, Li YF, Jiang ZL
Drug Design, Development and Therapy 2017, 11:617-627
Published Date: 3 March 2017
Metal complexes in cancer therapy – an update from drug design perspective
Ndagi U, Mhlongo N, Soliman ME
Drug Design, Development and Therapy 2017, 11:599-616
Published Date: 3 March 2017
Awake craniotomy anesthetic management using dexmedetomidine, propofol, and remifentanil
Prontera A, Baroni S, Marudi A, Valzania F, Feletti A, Benuzzi F, Bertellini E, Pavesi G
Drug Design, Development and Therapy 2017, 11:593-598
Published Date: 3 March 2017
Rifapentine-linezolid-loaded PLGA microspheres for interventional therapy of cavitary pulmonary tuberculosis: preparation and in vitro characterization
Huang J, Chen Z, Li Y, Li L, Zhang G
Drug Design, Development and Therapy 2017, 11:585-592
Published Date: 3 March 2017
Human papillomavirus (HPV): systemic treatment with Gene-Eden-VIR/Novirin safely and effectively clears virus
Polansky H, Itzkovitz E, Javaherian A
Drug Design, Development and Therapy 2017, 11:575-583
Published Date: 3 March 2017
In silico discovery and in vitro activity of inhibitors against Mycobacterium tuberculosis 7,8-diaminopelargonic acid synthase (Mtb BioA)
Billones JB, Carrillo MCO, Organo VG, Sy JBA, Clavio NAB, Macalino SJY, Emnacen IA, Lee AP, Ko PKL, Concepcion GP
Drug Design, Development and Therapy 2017, 11:563-574
Published Date: 2 March 2017
Adenosine A2A receptor agonist prevents cardiac remodeling and dysfunction in spontaneously hypertensive male rats after myocardial infarction
da Silva JS, Gabriel-Costa D, Sudo RT, Wang H, Groban L, Ferraz EB, Nascimento JHM, Fraga CAM, Barreiro EJ, Zapata-Sudo G
Drug Design, Development and Therapy 2017, 11:553-562
Published Date: 6 March 2017
Defective DNA repair mechanisms in prostate cancer: impact of olaparib
De Felice F, Tombolini V, Marampon F, Musella A, Marchetti C
Drug Design, Development and Therapy 2017, 11:547-552
Published Date: 1 March 2017
Eteplirsen in the treatment of Duchenne muscular dystrophy
Lim KRQ, Maruyama R, Yokota T
Drug Design, Development and Therapy 2017, 11:533-545
Published Date: 28 February 2017
Improvement of skin condition in striae distensae: development, characterization and clinical efficacy of a cosmetic product containing Punica granatum seed oil and Croton lechleri resin extract
Bogdan C, Iurian S, Tomuta I, Moldovan M
Drug Design, Development and Therapy 2017, 11:521-531
Published Date: 24 February 2017
Combined application of dexamethasone and hyperbaric oxygen therapy yields better efficacy for patients with delayed encephalopathy after acute carbon monoxide poisoning
Xiang W, Xue H, Wang B, Li C, Zhang J, Jiang C, Liang F, Pang J, Yu L
Drug Design, Development and Therapy 2017, 11:513-519
Published Date: 23 February 2017
Pharmacokinetic interactions between glimepiride and rosuvastatin in healthy Korean subjects: does the SLCO1B1 or CYP2C9 genetic polymorphism affect these drug interactions?
Kim CO, Oh ES, Kim H, Park MS
Drug Design, Development and Therapy 2017, 11:503-512
Published Date: 23 February 2017
Sofosbuvir/velpatasvir regimen promises an effective pan-genotypic hepatitis C virus cure
Mir F, Kahveci AS, Ibdah JA, Tahan V
Drug Design, Development and Therapy 2017, 11:497-502
Published Date: 23 February 2017
Polyphosphoester nanoparticles as biodegradable platform for delivery of multiple drugs and siRNA
Elzeny H, Zhang F, Ali EN, Fathi HA, Zhang S, Li R, El-Mokhtar MA, Hamad MA, Wooley KL, Elsabahy M
Drug Design, Development and Therapy 2017, 11:483-496
Published Date: 22 February 2017
Antiproliferation effect of imatinib mesylate on MCF7, T-47D tumorigenic and MCF 10A nontumorigenic breast cell lines via PDGFR-β, PDGF-BB, c-Kit and SCF genes
Kadivar A, Kamalidehghan B, Akbari Javar H, Karimi B, Sedghi R, Noordin MI
Drug Design, Development and Therapy 2017, 11:469-481
Published Date: 21 February 2017
Profile of mirabegron in the treatment of overactive bladder: place in therapy
Sharaf A, Hashim H
Drug Design, Development and Therapy 2017, 11:463-467
Published Date: 20 February 2017
Insight into resistance mechanisms of AZD4547 and E3810 to FGFR1 gatekeeper mutation via theoretical study
Liang D, Chen Q, Guo Y, Zhang T, Guo W
Drug Design, Development and Therapy 2017, 11:451-461
Published Date: 17 February 2017
Reversal of multidrug resistance in human lung cancer cells by delivery of 3-octadecylcarbamoylacrylic acid–cisplatin-based liposomes
Song J, Ren W, Xu T, Zhang Y, Guo H, Zhu S, Yang L
Drug Design, Development and Therapy 2017, 11:441-449
Published Date: 17 February 2017
Curcumin induces apoptosis and protective autophagy in castration-resistant prostate cancer cells through iron chelation
Yang C, Ma X, Wang Z, Zeng X, Hu Z, Ye Z, Shen G
Drug Design, Development and Therapy 2017, 11:431-439
Published Date: 14 February 2017
Conjugation of metronidazole with dextran: a potential pharmaceutical strategy to control colonic distribution of the anti-amebic drug susceptible to metabolism by colonic microbes
Kim W, Yang Y, Kim D, Jeong S, Yoo J, Yoon JH, Jung Y
Drug Design, Development and Therapy 2017, 11:419-429
Published Date: 14 February 2017
Novel 5-oxo-hexahydroquinoline derivatives: design, synthesis, in vitro P-glycoprotein-mediated multidrug resistance reversal profile and molecular dynamics simulation study
Shahraki O, Edraki N, Khoshneviszadeh M, Zargari F, Ranjbar S, Saso L, Firuzi O, Miri R
Drug Design, Development and Therapy 2017, 11:407-418
Published Date: 14 February 2017
Oral and transdermal drug delivery systems: role of lipid-based lyotropic liquid crystals
Rajabalaya R, Musa MN, Kifli N, David SR
Drug Design, Development and Therapy 2017, 11:393-406
Published Date: 13 February 2017
Antioxidant compounds and activities of the stem, flower, and leaf extracts of the anti-smoking Thai medicinal plant: Vernonia cinerea Less
Ketsuwan N, Leelarungrayub J, Kothan S, Singhatong S
Drug Design, Development and Therapy 2017, 11:383-391
Published Date: 13 February 2017
Pharmacokinetics of conivaptan use in patients with severe hepatic impairment
Marbury T, Fox J, Kaelin B, Pavliv L
Drug Design, Development and Therapy 2017, 11:373-382
Published Date: 13 February 2017
Evaluation of effects of various drugs on platelet functions using phorbol 12-myristate 13-acetate-induced megakaryocytic human erythroid leukemia cells [Corrigendum]
Tada T, Aki K, Oboshi W, Kawazoe K, Yasui T, Hosoi E
Drug Design, Development and Therapy 2017, 11:371-372
Published Date: 8 February 2017
Effect of dexmedetomidine in preventing etomidate-induced myoclonus: a meta-analysis
Du X, Zhou C, Pan L, Li C
Drug Design, Development and Therapy 2017, 11:365-370
Published Date: 8 February 2017
Gancidin W, a potential low-toxicity antimalarial agent isolated from an endophytic Streptomyces SUK10
Zin NM, Baba MS, Zainal-Abidin AH, Latip J, Mazlan NW, Edrada-Ebel R
Drug Design, Development and Therapy 2017, 11:351-363
Published Date: 8 February 2017
Kelussia odoratissima Mozaff. activates intrinsic pathway of apoptosis in breast cancer cells associated with S phase cell cycle arrest via involvement of p21/p27 in vitro and in vivo
Karimian H, Arya A, Fadaeinasab M, Razavi M, Hajrezaei M, Karim Khan A, Mohd Ali H, Abdulla MA, Noordin MI
Drug Design, Development and Therapy 2017, 11:337-350
Published Date: 1 February 2017
Drug delivery in overcoming the blood–brain barrier: role of nasal mucosal grafting
Marianecci C, Rinaldi F, Hanieh PN, Di Marzio L, Paolino D, Carafa M
Drug Design, Development and Therapy 2017, 11:325-335
Published Date: 27 January 2017
Phloretin exerts hypoglycemic effect in streptozotocin-induced diabetic rats and improves insulin resistance in vitro
Shen X, Zhou N, Mi L, Hu Z, Wang L, Liu X, Zhang S
Drug Design, Development and Therapy 2017, 11:313-324
Published Date: 7 February 2017
Impact of metoprolol treatment on mental status of chronic heart failure patients with neuropsychiatric disorders
Liu X, Lou X, Cheng X, Meng Y
Drug Design, Development and Therapy 2017, 11:305-312
Published Date: 25 January 2017
Obinutuzumab in chronic lymphocytic leukemia: design, development and place in therapy
Al-Sawaf O, Fischer K, Engelke A, Pflug N, Hallek M, Goede V
Drug Design, Development and Therapy 2017, 11:295-304
Published Date: 25 January 2017
Drugs in development for toxoplasmosis: advances, challenges, and current status
Alday PH, Doggett JS
Drug Design, Development and Therapy 2017, 11:273-293
Published Date: 25 January 2017
Theophylline action on primary human bronchial epithelial cells under proinflammatory stimuli and steroidal drugs: a therapeutic rationale approach
Gallelli L, Falcone D, Cannataro R, Perri M, Serra R, Pelaia G, Maselli R, Savino R, Spaziano G, D’Agostino B
Drug Design, Development and Therapy 2017, 11:265-272
Published Date: 23 January 2017
Plitidepsin: design, development, and potential place in therapy
Alonso-Álvarez S, Pardal E, Sánchez-Nieto D, Navarro M, Caballero MD, Mateos MV, Martín A
Drug Design, Development and Therapy 2017, 11:253-264
Published Date: 19 January 2017
Effect of roll compaction on granule size distribution of microcrystalline cellulose–mannitol mixtures: computational intelligence modeling and parametric analysis
Kazemi P, Khalid MH, Pérez Gago A, Kleinebudde P, Jachowicz R, Szlęk J, Mendyk A
Drug Design, Development and Therapy 2017, 11:241-251
Published Date: 18 January 2017
N-(3-hydroxymethyl-β-carboline-1-yl-ethyl-2-yl)-L-Phe: development toward a nanoscaled antitumor drug capable of treating complicated thrombosis and inflammation
Wu JH, Zhao M, Wang YJ, Wang YN, Zhu HM, Zhao SR, Gui L, Zhang XY, Peng SQ
Drug Design, Development and Therapy 2017, 11:225-239
Published Date: 17 January 2017
Spotlight on mavrilimumab for the treatment of rheumatoid arthritis: evidence to date
Crotti C, Raimondo MG, Becciolini A, Biggioggero M, Favalli EG
Drug Design, Development and Therapy 2017, 11:211-223
Published Date: 13 January 2017
Comparison of the long-term efficacy and safety of generic Tacrobell with original tacrolimus (Prograf) in kidney transplant recipients
Son SY, Jang HR, Lee JE, Yoo H, Kim K, Park JB, Kim SJ, Oh HY, Huh W
Drug Design, Development and Therapy 2017, 11:203-210
Published Date: 12 January 2017
Computational intelligence models to predict porosity of tablets using minimum features
Khalid MH, Kazemi P, Perez-Gandarillas L, Michrafy A, Szlęk J, Jachowicz R, Mendyk A
Drug Design, Development and Therapy 2017, 11:193-202
Published Date: 12 January 2017
Facilitated saliva secretion and reduced oral inflammation by a novel artificial saliva system in the treatment of salivary hypofunction
Kang M, Park H, Jun JH, Son M, Kang MJ
Drug Design, Development and Therapy 2017, 11:185-191
Published Date: 11 January 2017
Immunotherapy for the treatment of colorectal tumors: focus on approved and in-clinical-trial monoclonal antibodies
Françoso A, Simioni PU
Drug Design, Development and Therapy 2017, 11:177-184
Published Date: 11 January 2017
Golimumab in radiographic and nonradiographic axial spondyloarthritis: a review of clinical trials [Corrigendum]
Toussirot E, Vauchy C, Binda D, Michel F
Drug Design, Development and Therapy 2017, 11:175-176
Published Date: 11 January 2017
Resveratrol inhibits transforming growth factor-β2-induced epithelial-to-mesenchymal transition in human retinal pigment epithelial cells by suppressing the Smad pathway
Chen CL, Chen YH, Tai MC, Liang CM, Lu DW, Chen JT
Drug Design, Development and Therapy 2017, 11:163-173
Published Date: 11 January 2017
Evaluation of a 2-aminoimidazole variant as adjuvant treatment for dermal bacterial infections
Draughn GL, Allen CL, Routh PA, Stone MR, Kirker KR, Boegli L, Schuchman RM, Linder KE, Baynes RE, James G, Melander C, Pollard A, Cavanagh J
Drug Design, Development and Therapy 2017, 11:153-162
Published Date: 11 January 2017
Spotlight on opicapone as an adjunct to levodopa in Parkinson’s disease: design, development and potential place in therapy
Annus Á, Vécsei L
Drug Design, Development and Therapy 2017, 11:143-151
Published Date: 9 January 2017
Pharmacokinetic and pharmacodynamic evaluation according to absorption differences in three formulations of ibuprofen
Shin D, Lee SJ, Ha Y, Choi YS, Kim JW, Park SR, Park MK
Drug Design, Development and Therapy 2017, 11:135-141
Published Date: 4 January 2017
A triazole derivative elicits autophagic clearance of polyglutamine aggregation in neuronal cells [Corrigendum]
Hsieh CH, Lee LC, Leong WY, Yang TC, Yao CF, Fang K
Drug Design, Development and Therapy 2017, 11:133-134
Published Date: 28 December 2016
Effects of multiple-dose ponesimod, a selective S1P1 receptor modulator, on lymphocyte subsets in healthy humans
Jurcevic S, Juif PE, Hamid C, Greenlaw R, D'Ambrosio D, Dingemanse J
Drug Design, Development and Therapy 2017, 11:123-131
Published Date: 28 December 2016
Anticancer and anti-inflammatory activities of girinimbine isolated from Murraya koenigii
Iman V, Mohan S, Abdelwahab SI, Karimian H, Nordin N, Fadaeinasab M, Noordin MI, Noor SM
Drug Design, Development and Therapy 2017, 11:103-121
Published Date: 28 December 2016
Vitamin D deficiency and the risk of tuberculosis: a meta-analysis
Huang SJ, Wang XH, Liu ZD, Cao WL, Han Y, Ma AG, Xu SF
Drug Design, Development and Therapy 2017, 11:91-102
Published Date: 28 December 2016
Analysis of pramipexole dose–response relationships in Parkinson's disease
Wang Y, Sun SG, Zhu SQ, Liu CF, Liu YM, Di Q, Shang HF, Ren Y, Xiang W, Chen SD
Drug Design, Development and Therapy 2017, 11:83-89
Published Date: 23 December 2016
Critical role of tedizolid in the treatment of acute bacterial skin and skin structure infections
Ferrández O, Urbina O, Grau S
Drug Design, Development and Therapy 2017, 11:65-82
Published Date: 22 December 2016
Riluzole 5 mg/mL oral suspension: for optimized drug delivery in amyotrophic lateral sclerosis
Dyer AM, Smith A
Drug Design, Development and Therapy 2017, 11:59-64
Published Date: 22 December 2016
Development of a chitosan based double layer-coated tablet as a platform for colon-specific drug delivery
Kim MS, Yeom DW, Kim SR, Yoon HY, Kim CH, Son HY, Kim JH, Lee S, Choi YW
Drug Design, Development and Therapy 2017, 11:45-57
Published Date: 21 December 2016
Spotlight on the 9-valent HPV vaccine
Lopalco PL
Drug Design, Development and Therapy 2017, 11:35-44
Published Date: 20 December 2016
Nitroglycerin enhances the propagation of cortical spreading depression: comparative studies with sumatriptan and novel kynurenic acid analogues
Knapp L, Szita B, Kocsis K, Vécsei L, Toldi J
Drug Design, Development and Therapy 2017, 11:27-34
Published Date: 20 December 2016
Development of docetaxel nanocrystals surface modified with transferrin for tumor targeting
Choi JS, Park JS
Drug Design, Development and Therapy 2017, 11:17-26
Published Date: 16 December 2016
Gastroretentive behavior of orally administered radiolabeled tamarind seed formulations in rabbits validated by gamma scintigraphy
Razavi M, Karimian H, Yeong CH, Fadaeinasab M, Khaing SL, Chung LY, Mohamad Haron DE, Noordin MI
Drug Design, Development and Therapy 2017, 11:1-15
Published Date: 19 December 2016