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Drug Design, Development and Therapy


Archive: Volume 11, 2017

In silico-based identification of human α-enolase inhibitors to block cancer cell growth metabolically

Lung J, Chen KL, Hung CH, Chen CC, Hung MS, Lin YC, Wu CY, Lee KD, Shih NY, Tsai YH

Drug Design, Development and Therapy 2017, 11:3281-3290

Published Date: 16 November 2017

Differences of statin activity in 2D and 3D pancreatic cancer cell cultures

Paškevičiūtė M, Petrikaitė V

Drug Design, Development and Therapy 2017, 11:3273-3280

Published Date: 16 November 2017

Role of nebulized glycopyrrolate in the treatment of chronic obstructive pulmonary disease

Santus P, Radovanovic D, Cristiano A, Valenti V, Rizzi M

Drug Design, Development and Therapy 2017, 11:3257-3271

Published Date: 15 November 2017

Novel production method of innovative antiangiogenic and antitumor small peptides in Escherichia coli

Setrerrahmane S, Yu J, Hao J, Zheng H, Xu H

Drug Design, Development and Therapy 2017, 11:3207-3220

Published Date: 8 November 2017

Impact of baseline blood pressure on the magnitude of blood pressure lowering by nifedipine gastrointestinal therapeutic system: refreshing the Wilder’s principle

Hu HJ, Zhang JD, Wang Y, Tian ZJ, Liu DM, Zhang GM, Gu GQ, Zheng HM, Xie RQ, Cui W

Drug Design, Development and Therapy 2017, 11:3179-3186

Published Date: 6 November 2017

Baracle® vs Baraclude® for 48 weeks in patients with treatment-naïve chronic hepatitis B: a comparison of efficacy and safety

Kim DY, Kim JH, Tak WY, Yeon JE, Lee JH, Yoon JH, Lee YJ, Lee BS, Han BH, Lee HC

Drug Design, Development and Therapy 2017, 11:3145-3152

Published Date: 31 October 2017

Severe eosinophilic asthma: from the pathogenic role of interleukin-5 to the therapeutic action of mepolizumab

Pelaia C, Vatrella A, Busceti MT, Gallelli L, Terracciano R, Savino R, Pelaia G

Drug Design, Development and Therapy 2017, 11:3137-3144

Published Date: 30 October 2017

Vitamin D levels in systemic sclerosis patients: a meta-analysis

An L, Sun M, Chen F, Li J

Drug Design, Development and Therapy 2017, 11:3119-3125

Published Date: 27 October 2017

High-dose dexamethasone induced LPS-stimulated rat alveolar macrophages apoptosis

Zeng S, Qiao H, Lv XW, Fan D, Liu T, Xie D

Drug Design, Development and Therapy 2017, 11:3097-3104

Published Date: 25 October 2017

Enhanced antitumor efficacy of poly(D,L-lactide-co-glycolide)-based methotrexate-loaded implants on sarcoma 180 tumor-bearing mice

Gao L, Xia L, Zhang R, Duan D, Liu X, Xu J, Luo L

Drug Design, Development and Therapy 2017, 11:3065-3075

Published Date: 20 October 2017

10H-3,6-Diazaphenothiazine induces G2/M phase cell cycle arrest and caspase-dependent apoptosis and inhibits cell invasion of A2780 ovarian carcinoma cells through the regulation of NF-κB and (BIRC6-XIAP) complexes

Zhang J, Ming C, Zhang W, Okechukwu PN, Morak-Młodawska B, Pluta K, Jeleń M, Akim AM, Ang KP, Ooi KK

Drug Design, Development and Therapy 2017, 11:3045-3063

Published Date: 24 October 2017

Failure mode and effects analysis drastically reduced potential risks in clinical trial conduct

Lee H, Lee H, Baik J, Kim HJ, Kim R

Drug Design, Development and Therapy 2017, 11:3035-3043

Published Date: 19 October 2017

Edaravone inhibits pressure overload-induced cardiac fibrosis and dysfunction by reducing expression of angiotensin II AT1 receptor

Zhang WW, Bai F, Wang J, Zheng RH, Yang LW, James EA, Zhao ZQ

Drug Design, Development and Therapy 2017, 11:3019-3033

Published Date: 16 October 2017

Amelioration of collagen-induced arthritis using antigen-loaded dendritic cells modified with NF-κB decoy oligodeoxynucleotides

Jiang HM, Hu HG, Zhang YL, Yue P, Ning LC, Zhou Y, Shi P, Yuan R

Drug Design, Development and Therapy 2017, 11:2997-3007

Published Date: 13 October 2017

5H-benzo[h]thiazolo[2,3-b]quinazolines ameliorate NDEA-induced hepatocellular carcinogenesis in rats through IL-6 downregulation along with oxidative and metabolic stress reduction

Keshari AK, Singh AK, Kumar U, Raj V, Rai A, Kumar P, Kumar D, Maity B, Nath S, Prakash A, Saha S

Drug Design, Development and Therapy 2017, 11:2981-2995

Published Date: 13 October 2017

Protective effect of DA-9401 in finasteride-induced apoptosis in rat testis: inositol requiring kinase 1 and c-Jun N-terminal kinase pathway

Soni KK, Shin YS, Choi BR, Karna KK, Kim HK, Lee SW, Kim CY, Park JK

Drug Design, Development and Therapy 2017, 11:2969-2979

Published Date: 11 October 2017

Halofuginone ameliorates inflammation in severe acute hepatitis B virus (HBV)-infected SD rats through AMPK activation

Zhan WL, Kang YH, Chen N, Mao CS, Kang Y, Shang J

Drug Design, Development and Therapy 2017, 11:2947-2955

Published Date: 10 October 2017

Short vs prolonged dual antiplatelet treatment upon endovascular stenting of peripheral arteries

Kronlage M, Wassmann M, Vogel B, Müller OJ, Blessing E, Katus H, Erbel C

Drug Design, Development and Therapy 2017, 11:2937-2945

Published Date: 6 October 2017

Spotlight on ertugliflozin and its potential in the treatment of type 2 diabetes: evidence to date

Cinti F, Moffa S, Impronta F, Cefalo CMA, Sun VA, Sorice GP, Mezza T, Giaccari A

Drug Design, Development and Therapy 2017, 11:2905-2919

Published Date: 3 October 2017

Current perspective on rituximab in rheumatic diseases

Schioppo T, Ingegnoli F

Drug Design, Development and Therapy 2017, 11:2891-2904

Published Date: 3 October 2017

The new era of nanotechnology, an alternative to change cancer treatment

Jurj A, Braicu C, Pop LA, Tomuleasa C, Gherman CD, Berindan-Neagoe I

Drug Design, Development and Therapy 2017, 11:2871-2890

Published Date: 27 September 2017

Downregulation of A20 increases the cytotoxicity of IFN-γ in hepatocellular carcinoma cells

Yin L, Fang Z, Shen N, Qiu Y, Li A, Zhang Y

Drug Design, Development and Therapy 2017, 11:2841-2850

Published Date: 26 September 2017

Eluxadoline in the treatment of diarrhea-predominant irritable bowel syndrome

Özdener AE, Rivkin A

Drug Design, Development and Therapy 2017, 11:2827-2840

Published Date: 26 September 2017

Axitinib in the treatment of renal cell carcinoma: design, development, and place in therapy

Bellesoeur A, Carton E, Alexandre J, Goldwasser F, Huillard O

Drug Design, Development and Therapy 2017, 11:2801-2811

Published Date: 21 September 2017

Dexmedetomidine reduces the neuronal apoptosis related to cardiopulmonary bypass by inhibiting activation of the JAK2–STAT3 pathway

Chen Y, Zhang X, Zhang B, He G, Zhou L, Xie Y

Drug Design, Development and Therapy 2017, 11:2787-2799

Published Date: 26 September 2017

Biodegradable rifampicin-releasing coating of surgical meshes for the prevention of bacterial infections

Reinbold J, Hierlemann T, Urich L, Uhde AK, Müller I, Weindl T, Vogel U, Schlensak C, Wendel HP, Krajewski S

Drug Design, Development and Therapy 2017, 11:2753-2762

Published Date: 18 September 2017

The roles of epigallocatechin-3-gallate in the treatment of neuropathic pain: an update on preclinical in vivo studies and future perspectives

Bimonte S, Cascella M, Schiavone V, Mehrabi-Kermani F, Cuomo A

Drug Design, Development and Therapy 2017, 11:2737-2742

Published Date: 13 September 2017

Pharmacokinetic and safety evaluation of MB12066, an NQO1 substrate

Lee HW, Seong SJ, Ohk B, Kang WY, Gwon MR, Kim BK, Kim HJ, Yoon YR

Drug Design, Development and Therapy 2017, 11:2719-2725

Published Date: 13 September 2017

Localized neuropathic pain: an expert consensus on local treatments

Pickering G, Martin E, Tiberghien F, Delorme C, Mick G

Drug Design, Development and Therapy 2017, 11:2709-2718

Published Date: 13 September 2017

Metal organic frameworks as a drug delivery system for flurbiprofen

AL Haydar M, Abid HR, Sunderland B, Wang S

Drug Design, Development and Therapy 2017, 11:2685-2695

Published Date: 11 September 2017

Cissus quadrangularis inhibits IL-1β induced inflammatory responses on chondrocytes and alleviates bone deterioration in osteotomized rats via p38 MAPK signaling [Corrigendum]

Kanwar JR, Samarasinghe RM, Kumar K, Arya R, Sanjeev S, Zhou SF, Sasidharan S, Kanwar RK

Drug Design, Development and Therapy 2017, 11:2683-2684

Published Date: 12 September 2017

Extended infusion versus intermittent infusion of imipenem in the treatment of ventilator-associated pneumonia

Ibrahim MM, Tammam TF, Ebaed MED, Sarhan HA, Gad GF, Hussein AK

Drug Design, Development and Therapy 2017, 11:2677-2682

Published Date: 6 September 2017

Palatability and physical properties of potassium-binding resin RDX7675: comparison with sodium polystyrene sulfonate

Zann V, McDermott J, Jacobs JW, Davidson JP, Lin F, Korner P, Blanks RC, Rosenbaum DP

Drug Design, Development and Therapy 2017, 11:2663-2673

Published Date: 6 September 2017

In vitro inhibitory activities of magnolol against Candida spp.

Zhou PR, Fu JY, Hua H, Liu XS

Drug Design, Development and Therapy 2017, 11:2653-2661

Published Date: 6 September 2017

Radium 223 dichloride for prostate cancer treatment

Deshayes E, Roumiguie M, Thibault C, Beuzeboc P, Cachin F, Hennequin C, Huglo D, Rozet F, Kassab-Chahmi D, Rebillard X, Houédé N

Drug Design, Development and Therapy 2017, 11:2643-2651

Published Date: 6 September 2017

Recent developments in the clinical pharmacology of rolapitant: subanalyses in specific populations

Rapoport BL, Aapro M, Chasen MR, Jordan K, Navari RM, Schnadig I, Schwartzberg L

Drug Design, Development and Therapy 2017, 11:2621-2629

Published Date: 5 September 2017

Protective role of quercetin against manganese-induced injury in the liver, kidney, and lung; and hematological parameters in acute and subchronic rat models

Bahar E, Lee GH, Bhattarai KR, Lee HY, Kim HK, Handigund M, Choi MK, Han SY, Chae HJ, Yoon H

Drug Design, Development and Therapy 2017, 11:2605-2619

Published Date: 5 September 2017

Puerarin transport across rat nasal epithelial cells and the influence of compatibility with paeoniflorin and menthol

Zhang L, Du S, Lu Y, Liu C, Wu H, Tian Z, Wang M, Yang C

Drug Design, Development and Therapy 2017, 11:2581-2593

Published Date: 1 September 2017

Quantum mechanics implementation in drug-design workflows: does it really help?

Arodola OA, Soliman MES

Drug Design, Development and Therapy 2017, 11:2551-2564

Published Date: 31 August 2017

New insight into the pathogenesis of nail psoriasis and overview of treatment strategies

Ventura A, Mazzeo M, Gaziano R, Galluzzo M, Bianchi L, Campione E

Drug Design, Development and Therapy 2017, 11:2527-2535

Published Date: 30 August 2017

Secondary prevention of major cerebrovascular events with seven different statins: a multi-treatment meta-analysis

Zhong P, Wu D, Ye X, Wu Y, Li T, Tong S, Liu X

Drug Design, Development and Therapy 2017, 11:2517-2526

Published Date: 30 August 2017

Therapy with pamidronate in children with osteogenesis imperfecta

Marginean O, Tamasanu RC, Mang N, Mozos I, Brad GF

Drug Design, Development and Therapy 2017, 11:2507-2515

Published Date: 28 August 2017

Advances in the delivery of buprenorphine for opioid dependence

Rosenthal RN, Goradia VV

Drug Design, Development and Therapy 2017, 11:2493-2505

Published Date: 28 August 2017

Paeoniflorin suppresses pancreatic cancer cell growth by upregulating HTRA3 expression

Li YJ, Gong LL, Qi RL, Sun Q, Xia XX, He HH, Ren JS, Zhu ON, Zhuo DB

Drug Design, Development and Therapy 2017, 11:2481-2491

Published Date: 23 August 2017

Preliminary study of nanonized lamotrigine containing products for nasal powder formulation

Gieszinger P, Csóka I, Pallagi E, Katona G, Jójárt-Laczkovich O, Szabó-Révész P, Ambrus R

Drug Design, Development and Therapy 2017, 11:2453-2466

Published Date: 23 August 2017

Aceclofenac nanocrystals with enhanced in vitro, in vivo performance: formulation optimization, characterization, analgesic and acute toxicity studies

Rahim H, Sadiq A, Khan S, Khan MA, Shah SMH, Hussain Z, Ullah R, Shahat AA, Ibrahim K

Drug Design, Development and Therapy 2017, 11:2443-2452

Published Date: 23 August 2017

Sensitization of gastric cancer cells to alkylating agents by glaucocalyxin B via cell cycle arrest and enhanced cell death

Ur Rahman MS, Zhang L, Wu LY, Xie YQ, Li CC, Cao J

Drug Design, Development and Therapy 2017, 11:2431-2441

Published Date: 22 August 2017

Metformin: a review of its potential indications

Wang YW, He SJ, Feng X, Cheng J, Luo YT, Tian L, Huang Q

Drug Design, Development and Therapy 2017, 11:2421-2429

Published Date: 22 August 2017

Pomalidomide in the treatment of multiple myeloma: design, development and place in therapy

Rios-Tamayo R, Martín-García A, Alarcón-Payer C, Sánchez-Rodríguez D, Guardia AM, García Collado CG, Jiménez Morales A, Jurado Chacón M, Cabeza Barrera J

Drug Design, Development and Therapy 2017, 11:2399-2408

Published Date: 22 August 2017

Onychomadesis associated with chemotherapy: case report and mini literature review

Li A, Li Y, Ge L, Li P, Li W

Drug Design, Development and Therapy 2017, 11:2373-2376

Published Date: 14 August 2017

Widening use of dexamethasone implant for the treatment of macular edema

Bonfiglio V, Reibaldi M, Fallico M, Russo A, Pizzo A, Fichera S, Rapisarda C, Macchi I, Avitabile T, Longo A

Drug Design, Development and Therapy 2017, 11:2359-2372

Published Date: 16 August 2017

Microbial challenge test of a novel epoprostenol sodium formulation

Bandilla D, Goverde M, Giudici P, Lambert O

Drug Design, Development and Therapy 2017, 11:2347-2357

Published Date: 10 August 2017

Isatin-benzoazine molecular hybrids as potential antiproliferative agents: synthesis and in vitro pharmacological profiling

Abdel-Aziz HA, Eldehna WM, Keeton AB, Piazza GA, Kadi AA, Attwa MW, Abdelhameed AS, Attia MI

Drug Design, Development and Therapy 2017, 11:2333-2346

Published Date: 9 August 2017

Modeling the human Nav1.5 sodium channel: structural and mechanistic insights of ion permeation and drug blockade

Ahmed M, Jalily Hasani H, Ganesan A, Houghton M, Barakat K

Drug Design, Development and Therapy 2017, 11:2301-2324

Published Date: 4 August 2017

Safety of switching from brand-name to generic levetiracetam in patients with epilepsy

Bosak M, Słowik A, Turaj W

Drug Design, Development and Therapy 2017, 11:2287-2291

Published Date: 3 August 2017

Intracellular trafficking of new anticancer therapeutics: antibody–drug conjugates

Kalim M, Chen J, Wang S, Lin C, Ullah S, Liang K, Ding Q, Chen S, Zhan JB

Drug Design, Development and Therapy 2017, 11:2265-2276

Published Date: 2 August 2017

Markers of oxidative/nitrosative stress and inflammation in lung tissue of rats exposed to different intravenous iron compounds

Toblli JE, Cao G, Giani JF, Dominici FP, Angerosa M

Drug Design, Development and Therapy 2017, 11:2251-2263

Published Date: 1 August 2017

Comparative analysis of essential oil composition of Iranian and Indian Nigella sativa L. extracted using supercritical fluid extraction and solvent extraction

Ghahramanloo KH, Kamalidehghan B, Akbari Javar H, Teguh Widodo R, Majidzadeh K, Noordin MI

Drug Design, Development and Therapy 2017, 11:2221-2226

Published Date: 28 July 2017

Antibiotic susceptibility, heteroresistance, and updated treatment strategies in Helicobacter pylori infection

Mascellino MT, Porowska B, De Angelis M, Oliva A

Drug Design, Development and Therapy 2017, 11:2209-2220

Published Date: 28 July 2017

Schisandrin B attenuates CCl4-induced liver fibrosis in rats by regulation of Nrf2-ARE and TGF-β/Smad signaling pathways

Chen QS, Zhang H, Cao Y, Li Y, Sun S, Zhang JP, Zhang GQ

Drug Design, Development and Therapy 2017, 11:2179-2191

Published Date: 26 July 2017

The modulation of enzyme indoleamine 2,3-dioxygenase from dendritic cells for the treatment of type 1 diabetes mellitus

Abram DM, Fernandes LGR, Ramos Filho ACS, Simioni PU

Drug Design, Development and Therapy 2017, 11:2171-2178

Published Date: 24 July 2017

Using dezocine to prevent etomidate-induced myoclonus: a meta-analysis of randomized trials

Zhu Y, Yang Y, Zhou C, Bao Z

Drug Design, Development and Therapy 2017, 11:2163-2170

Published Date: 18 July 2017

Efficacy and safety of direct-acting antiviral therapy in previous hard-to-treat patients with recurrent hepatitis C virus infection after liver transplantation: a real-world cohort

Bernuth S, Grimm D, Vollmar J, Darstein F, Mittler J, Heise M, Hoppe-Lotichius M, Galle PR, Lang H, Zimmermann T

Drug Design, Development and Therapy 2017, 11:2131-2138

Published Date: 12 July 2017

Clinical utility of evolocumab in the management of hyperlipidemia: patient selection and follow-up

Dixon DL, Buckley LF, Trankle CR, Kadariya D, Abbate A

Drug Design, Development and Therapy 2017, 11:2121-2129

Published Date: 11 July 2017

Evaluation of the stability of linezolid in aqueous solution and commonly used intravenous fluids

Taylor R, Sunderland B, Luna G, Czarniak P

Drug Design, Development and Therapy 2017, 11:2087-2097

Published Date: 10 July 2017

Spotlight on ceritinib in the treatment of ALK+ NSCLC: design, development and place in therapy

Santarpia M, Daffinà MG, D'Aveni A, Marabello G, Liguori A, Giovannetti E, Karachaliou N, Gonzalez Cao M, Rosell R, Altavilla G

Drug Design, Development and Therapy 2017, 11:2047-2063

Published Date: 5 July 2017

Development of highly potent melanogenesis inhibitor by in vitro, in vivo and computational studies

Abbas Q, Ashraf Z, Hassan M, Nadeem H, Latif M, Afzal S, Seo S

Drug Design, Development and Therapy 2017, 11:2029-2046

Published Date: 5 July 2017

Synthesis and antimicrobial activity of chiral quaternary N-spiro ammonium bromides with 3',4'-dihydro-1'H-spiro[isoindoline-2,2'-isoquinoline] skeleton

Bielawski K, Leszczyńska K, Kałuża Z, Bielawska A, Michalak O, Daniluk T, Staszewska-Krajewska O, Czajkowska A, Pawłowska N, Gornowicz A

Drug Design, Development and Therapy 2017, 11:2015-2028

Published Date: 5 July 2017

Targeted therapy in severe asthma today: focus on immunoglobulin E

Pelaia G, Canonica GW, Matucci A, Paolini R, Triggiani M, Paggiaro P

Drug Design, Development and Therapy 2017, 11:1979-1987

Published Date: 29 June 2017

Cell and small animal models for phenotypic drug discovery

Szabo M, Svensson Akusjärvi S, Saxena A, Liu J, Chandrasekar G, Kitambi SS

Drug Design, Development and Therapy 2017, 11:1957-1967

Published Date: 28 June 2017

Determining optimal dosing regimen of oral administration of dicloxacillin using Monte Carlo simulation

Yu W, Ji J, Xiao T, Ying C, Fang J, Shen P, Xiao Y

Drug Design, Development and Therapy 2017, 11:1951-1956

Published Date: 28 June 2017

Comparison of neurotoxic potency between a novel chinbotulinumtoxinA with onabotulinumtoxinA, incobotulinumtoxinA and lanbotulinumtoxinA in rats

Feng Y, Liu WC, Pan LZ, Jiang C, Zhang CX, Lu YX, Nie ZY, Jin LJ

Drug Design, Development and Therapy 2017, 11:1927-1939

Published Date: 28 June 2017

Effect of picroside II on hind limb ischemia reperfusion injury in rats

Kılıç Y, Özer A, Tatar T, Zor MH, Kirişçi M, Kartal H, Dursun AD, Billur D, Arslan M, Küçük A

Drug Design, Development and Therapy 2017, 11:1917-1925

Published Date: 26 June 2017

Antiglioma effects of cytarabine on leptomeningeal metastasis of high-grade glioma by targeting the PI3K/Akt/mTOR pathway

Zhao KH, Zhang C, Bai Y, Li Y, Kang X, Chen JX, Yao K, Jiang T, Zhong XS, Li WB

Drug Design, Development and Therapy 2017, 11:1905-1915

Published Date: 26 June 2017

Efficacy and safety of retinol palmitate ophthalmic solution in the treatment of dry eye: a Japanese Phase II clinical trial

Toshida H, Funaki T, Ono K, Tabuchi N, Watanabe S, Seki T, Otake H, Kato T, Ebihara N, Murakami A

Drug Design, Development and Therapy 2017, 11:1871-1879

Published Date: 23 June 2017

Molecular docking, QSAR and ADMET studies of withanolide analogs against breast cancer

Yadav DK, Kumar S, Saloni, Singh H, Kim M, Sharma P, Misra S, Khan F

Drug Design, Development and Therapy 2017, 11:1859-1870

Published Date: 22 June 2017

Differential effect of platelet-rich plasma fractions on β1-integrin signaling, collagen biosynthesis, and prolidase activity in human skin fibroblasts

Guszczyn T, Surażyński A, Zaręba I, Rysiak E, Popko J, Pałka J

Drug Design, Development and Therapy 2017, 11:1849-1857

Published Date: 22 June 2017

Enzymatic synthesis and in vitro evaluation of folate-functionalized liposomes

Guo B, Xu D, Liu X, Yi J

Drug Design, Development and Therapy 2017, 11:1839-1847

Published Date: 20 June 2017

Comparison of posttransplant outcomes in patients with no, acute, or chronic amiodarone use before heart transplantation

Rivinius R, Helmschrott M, Ruhparwar A, Darche FF, Thomas D, Bruckner T, Katus HA, Doesch AO

Drug Design, Development and Therapy 2017, 11:1827-1837

Published Date: 19 June 2017

Cryptotanshinone induces cell cycle arrest and apoptosis through the JAK2/STAT3 and PI3K/Akt/NFkB pathways in cholangiocarcinoma cells

Ke FY, Wang Z, Song XL, Ma Q, Hu YP, Jiang L, Zhang YJ, Liu YB, Zhang Y, Gong W

Drug Design, Development and Therapy 2017, 11:1753-1766

Published Date: 15 June 2017

Controlled release of optimized electroporation enhances the transdermal efficiency of sinomenine hydrochloride for treating arthritis in vitro and in clinic

Feng S, Zhu L, Huang Z, Wang H, Li H, Zhou H, Lu L, Wang Y, Liu Z, Liu L

Drug Design, Development and Therapy 2017, 11:1737-1752

Published Date: 15 June 2017

Efficacy of antibiotic treatment of implant-associated Staphylococcus aureus infections with moxifloxacin, flucloxacillin, rifampin, and combination therapy: an animal study

Greimel F, Scheuerer C, Gessner A, Simon M, Kalteis T, Grifka J, Benditz A, Springorum HR, Schaumburger J

Drug Design, Development and Therapy 2017, 11:1729-1736

Published Date: 14 June 2017

Lugano 2014 criteria for assessing FDG-PET/CT in lymphoma: an operational approach for clinical trials

Van Heertum RL, Scarimbolo R, Wolodzko JG, Klencke B, Messmann R, Tunc F, Sokol L, Agarwal R, Strafaci JA, O'Neal M

Drug Design, Development and Therapy 2017, 11:1719-1728

Published Date: 13 June 2017

Controlled-release nanoencapsulating microcapsules to combat inflammatory diseases

Baek JS, Yeo EW, Lee YH, Tan NS, Loo SCJ

Drug Design, Development and Therapy 2017, 11:1707-1717

Published Date: 8 June 2017

Development of new promising antimetabolite, DFP-11207 with self-controlled toxicity in rodents

Fukushima M, Iizuka K, Jin C, Zhang C, Hong M, Eshima K

Drug Design, Development and Therapy 2017, 11:1693-1705

Published Date: 7 June 2017

Renal function in heart transplant patients after switch to combined mammalian target of rapamycin inhibitor and calcineurin inhibitor therapy

Helmschrott M, Rivinius R, Bruckner T, Katus HA, Doesch AO

Drug Design, Development and Therapy 2017, 11:1673-1680

Published Date: 7 June 2017

Rhein attenuates inflammation through inhibition of NF-κB and NALP3 inflammasome in vivo and in vitro

Ge H, Tang H, Liang Y, Wu J, Yang Q, Zeng L, Ma Z

Drug Design, Development and Therapy 2017, 11:1663-1671

Published Date: 6 June 2017

CT-P13: design, development, and place in therapy

Gabbani T, Deiana S, Annese V

Drug Design, Development and Therapy 2017, 11:1653-1661

Published Date: 6 June 2017

Spotlight on ixekizumab for the treatment of moderate-to-severe plaque psoriasis: design, development, and use in therapy

Giunta A, Ventura A, Chimenti MS, Bianchi L, Esposito M

Drug Design, Development and Therapy 2017, 11:1643-1651

Published Date: 2 June 2017

Development of antiproliferative long-circulating liposomes co-encapsulating doxorubicin and curcumin, through the use of a quality-by-design approach

Tefas LR, Sylvester B, Tomuta I, Sesarman A, Licarete E, Banciu M, Porfire A

Drug Design, Development and Therapy 2017, 11:1605-1621

Published Date: 25 May 2017

Profile of sarilumab and its potential in the treatment of rheumatoid arthritis

Raimondo MG, Biggioggero M, Crotti C, Becciolini A, Favalli EG

Drug Design, Development and Therapy 2017, 11:1593-1603

Published Date: 24 May 2017

Effect of a food supplement containing berberine, monacolin K, hydroxytyrosol and coenzyme Q10 on lipid levels: a randomized, double-blind, placebo controlled study

D'Addato S, Scandiani L, Mombelli G, Focanti F, Pelacchi F, Salvatori E, Di Loreto G, Comandini A, Maffioli P, Derosa G

Drug Design, Development and Therapy 2017, 11:1585-1592

Published Date: 23 May 2017

Past and current perspective on new therapeutic targets for Type-II diabetes

Patil PD, Mahajan UB, Patil KR, Chaudhari S, Patil CR, Agrawal YO, Ojha S, Goyal SN

Drug Design, Development and Therapy 2017, 11:1567-1583

Published Date: 22 May 2017

Outcome of stroke patients receiving different doses of recombinant tissue plasminogen activator

Ong CT, Wong YS, Wu CS, Su YH

Drug Design, Development and Therapy 2017, 11:1559-1566

Published Date: 18 May 2017

Cisplatin induces protective autophagy through activation of BECN1 in human bladder cancer cells

Lin JF, Lin YC, Tsai TF, Chen HE, Chou KY, Hwang TIS

Drug Design, Development and Therapy 2017, 11:1517-1533

Published Date: 16 May 2017

Ten years of biosimilars in Europe: development and evolution of the regulatory pathways

Schiestl M, Zabransky M, Sörgel F

Drug Design, Development and Therapy 2017, 11:1509-1515

Published Date: 16 May 2017

Ten years of clinical experience with biosimilar human growth hormone: a review of safety data

Borrás Pérez MV, Kriström B, Romer T, Walczak M, Höbel N, Zabransky M

Drug Design, Development and Therapy 2017, 11:1497-1503

Published Date: 16 May 2017

Ten years' clinical experience with biosimilar human growth hormone: a review of efficacy data

López-Siguero JP, Pfäffle R, Chanson P, Szalecki M, Höbel N, Zabransky M

Drug Design, Development and Therapy 2017, 11:1489-1495

Published Date: 16 May 2017

Fabrication, characterization and in vitro evaluation of silibinin nanoparticles: an attempt to enhance its oral bioavailability

Sahibzada MUK, Sadiq A, Khan S, Faidah HS, Naseemullah, Khurram M, Amin MU, Haseeb A

Drug Design, Development and Therapy 2017, 11:1453-1464

Published Date: 15 May 2017

Preparation, characterization, and in vitro/vivo studies of oleanolic acid-loaded lactoferrin nanoparticles

Xia X, Liu H, Lv H, Zhang J, Zhou JP, Zhao Z

Drug Design, Development and Therapy 2017, 11:1417-1427

Published Date: 9 May 2017

Effect of epigallocatechin-3-gallate, major ingredient of green tea, on the pharmacokinetics of rosuvastatin in healthy volunteers

Kim TE, Ha N, Kim Y, Kim H, Lee JW, Jeon JY, Kim MG

Drug Design, Development and Therapy 2017, 11:1409-1416

Published Date: 9 May 2017

Propranolol therapy for infantile hemangioma: our experience

Zhang L, Wu HW, Yuan W, Zheng J

Drug Design, Development and Therapy 2017, 11:1401-1408

Published Date: 8 May 2017

Involvement of NF-κB and HSP70 signaling pathways in the apoptosis of MDA-MB-231 cells induced by a prenylated xanthone compound, α-mangostin, from Cratoxylum arborescens [Retraction]

Ibrahim MY, Hashim NM, Mohan S, Abdulla MA, Abdelwahab SI, Kamalidehghan B, Ghaderian M, Dehghan F, Ali LZ, Karimian H, Yahayu M, Ee GCL, Farjam AS, Ali HM

Drug Design, Development and Therapy 2017, 11:1399-1400

Published Date: 12 May 2017

Effect of electromagnetic fields and antioxidants on the trace element content of rat teeth

Dogan MS, Yavas MC, Yavuz Y, Erdogan S, Yener İ, Simsek İ, Akkus Z, Eratilla V, Tanik A, Akdag MZ

Drug Design, Development and Therapy 2017, 11:1393-1398

Published Date: 4 May 2017

Atorvastatin, a double weapon in osteoporosis treatment: an experimental and clinical study

El-Nabarawy N, El-Wakd M, Salem M

Drug Design, Development and Therapy 2017, 11:1383-1391

Published Date: 2 May 2017

Developing selective histone deacetylases (HDACs) inhibitors through ebselen and analogs

Wang Y, Wallach J, Duane S, Wang Y, Wu J, Wang J, Adejare A, Ma H

Drug Design, Development and Therapy 2017, 11:1369-1382

Published Date: 2 May 2017

Combined letrozole and clomiphene versus letrozole and clomiphene alone in infertile patients with polycystic ovary syndrome [Erratum]

Ghasemi-Rad M, Hajishafiha M, Dehghan M, Sadegh-Asadi N, Navid Shayegh S, Kiarang N

Drug Design, Development and Therapy 2017, 11:1367-1368

Published Date: 28 April 2017

Methanol leaf extract of Actinodaphne sesquipedalis (Lauraceae) enhances gastric defense against ethanol-induced ulcer in rats

Omar H, Nordin N, Hassandarvish P, Hajrezaie M, Azizan AHS, Fadaeinasab M, Abdul Majid N, Abdulla MA, Mohd Hashim N, Mohd Ali H

Drug Design, Development and Therapy 2017, 11:1353-1365

Published Date: 4 May 2017

Evaluation of the antitumor activity of NOV202, a novel microtubule targeting and vascular disrupting agent

Rickardson L, Kutvonen E, Orasniemi S, Högberg M, Kallio MJ, Rehnmark S

Drug Design, Development and Therapy 2017, 11:1335-1351

Published Date: 28 April 2017

Development and evaluation of a new modular nanotransporter for drug delivery into nuclei of pathological cells expressing folate receptors

Slastnikova TA, Rosenkranz AA, Khramtsov YV, Karyagina TS, Ovechko SA, Sobolev AS

Drug Design, Development and Therapy 2017, 11:1315-1334

Published Date: 26 April 2017

A first-in-human, double-blind, placebo-controlled, randomized, dose escalation study of DWP05195, a novel TRPV1 antagonist, in healthy volunteers

Lee J, Kim BH, Yu KS, Kim HS, Kim JD, Cho JY, Lee S, Gu N

Drug Design, Development and Therapy 2017, 11:1301-1313

Published Date: 24 April 2017

Proton-pump inhibitors use, and risk of acute kidney injury: a meta-analysis of observational studies

Yang Y, George KC, Shang WF, Zeng R, Ge SW, Xu G

Drug Design, Development and Therapy 2017, 11:1291-1299

Published Date: 24 April 2017

Functional characterization of wild-type and 24 CYP2D6 allelic variants on gefitinib metabolism in vitro

Fang P, Zheng X, He JY, Ge HL, Tang PF, Cai JP, Hu GX

Drug Design, Development and Therapy 2017, 11:1283-1290

Published Date: 21 April 2017

Anti-platelet effects of anti-glaucomatous eye drops: an in vitro study on human platelets

Moschos MM, Moustafa GA, Papakonstantinou VD, Tsatsos M, Laios K, Antonopoulou S

Drug Design, Development and Therapy 2017, 11:1267-1272

Published Date: 19 April 2017

Humanin rescues cultured rat cortical neurons from NMDA-induced toxicity through the alleviation of mitochondrial dysfunction

Cui A, Zhang Y, Li J, Song T, Liu X, Wang H, Zhang C, Ma G, Zhang H, Li K

Drug Design, Development and Therapy 2017, 11:1243-1253

Published Date: 18 April 2017

A comparative study on endovascular treatment of (sub)acute critical limb ischemia: mechanical thrombectomy vs thrombolysis

Kronlage M, Printz I, Vogel B, Blessing E, Müller OJ, Katus HA, Erbel C

Drug Design, Development and Therapy 2017, 11:1233-1241

Published Date: 18 April 2017

Vitamin D deficiency and tuberculosis: what about body mass index?

Hernández-Garduño E

Drug Design, Development and Therapy 2017, 11:1193-1194

Published Date: 11 April 2017

Bioequivalence study of a new sildenafil 100 mg orodispersible film compared to the conventional film-coated 100 mg tablet administered to healthy male volunteers

Radicioni M, Castiglioni C, Giori A, Cupone I, Frangione V, Rovati S

Drug Design, Development and Therapy 2017, 11:1183-1192

Published Date: 11 April 2017

Justification of disintegration testing beyond current FDA criteria using in vitro and in silico models

Uebbing L, Klumpp L, Webster GK, Löbenberg R

Drug Design, Development and Therapy 2017, 11:1163-1174

Published Date: 11 April 2017

Relaxin inhibits cardiac fibrosis and endothelial–mesenchymal transition via the Notch pathway [Corrigendum]

Zhou X, Chen X, Cai JJ, Chen LZ, Gong YS, Wang LX, Gao Z, Zhang HQ, Huang WJ, Zhou H

Drug Design, Development and Therapy 2017, 11:1159-1160

Published Date: 10 April 2017

Investigation of triamterene as an inhibitor of the TGR5 receptor: identification in cells and animals

Li Y, Cheng KC, Niu C, Lo S, Cheng JT, Niu H

Drug Design, Development and Therapy 2017, 11:1127-1134

Published Date: 5 April 2017

Phenotypic evaluation and in silico ADMET properties of novel arylimidamides in acute mouse models of Trypanosoma cruzi infection

da Silva CF, Batista DDGJ, de Araújo JS, Cunha-Junior EF, Stephens CE, Banerjee M, Farahat AA, Akay S, Fisher MK, Boykin DW, Soeiro MDNC

Drug Design, Development and Therapy 2017, 11:1095-1105

Published Date: 3 April 2017

Formulation, release characteristics, and bioavailability study of gastroretentive floating matrix tablet and floating raft system of Mebeverine HCl

El Nabarawi MA, Teaima MH, Abd El-Monem RA, El Nabarawy NA, Gaber DA

Drug Design, Development and Therapy 2017, 11:1081-1093

Published Date: 3 April 2017

Drug–drug interaction of microdose and regular-dose omeprazole with a CYP2C19 inhibitor and inducer

Park G, Bae SH, Park W, Han S, Park M, Shin S, Shin YG, Yim DS

Drug Design, Development and Therapy 2017, 11:1043-1053

Published Date: 30 March 2017

Mirtazapine for symptom control in refractory gastroparesis

Malamood M, Roberts A, Kataria R, Parkman HP, Schey R

Drug Design, Development and Therapy 2017, 11:1035-1041

Published Date: 30 March 2017

Rutin protects against neuronal damage in vitro and ameliorates doxorubicin-induced memory deficits in vivo in Wistar rats

Ramalingayya GV, Cheruku SP, Nayak PG, Kishore A, Shenoy R, Rao CM, Krishnadas N

Drug Design, Development and Therapy 2017, 11:1011-1026

Published Date: 29 March 2017

The antiulcer effect of Cibotium barometz leaves in rats with experimentally induced acute gastric ulcer

AL-Wajeeh NS, Hajrezaei M, Al-Henhena N, Kamran S, Bagheri E, Zahedifard M, Saremi K, Noor SM, Ali HM, Abdulla MA

Drug Design, Development and Therapy 2017, 11:995-1009

Published Date: 30 March 2017

An open randomized active-controlled clinical trial with low-dose SKA cytokines versus DMARDs evaluating low disease activity maintenance in patients with rheumatoid arthritis

Martin-Martin LS, Giovannangeli F, Bizzi E, Massafra U, Ballanti E, Cassol M, Migliore A

Drug Design, Development and Therapy 2017, 11:985-994

Published Date: 29 March 2017

Optimized formulation of multivesicular liposomes loaded with oleanolic acid enhanced anticancer effect in vitro

Wang Y, Luo Y, Li C, Zhang X, Pi C, Yu L, Wang S, Zhong Z

Drug Design, Development and Therapy 2017, 11:955-968

Published Date: 27 March 2017

Synergistic effects of antimicrobial peptide DP7 combined with antibiotics against multidrug-resistant bacteria

Wu X, Li Z, Li X, Tian Y, Fan Y, Yu C, Zhou B, Liu Y, Xiang R, Yang L

Drug Design, Development and Therapy 2017, 11:939-946

Published Date: 22 March 2017

Nanostructured lipid carriers for incorporation of copper(II) complexes to be used against Mycobacterium tuberculosis

Sato MR, Oshiro Junior JA, Machado RTA, de Souza PC, Campos DL, Pavan FR, da Silva PB, Chorilli M

Drug Design, Development and Therapy 2017, 11:909-921

Published Date: 20 March 2017

Clinical potential of SLAMF7 antibodies – focus on elotuzumab in multiple myeloma

Friend R, Bhutani M, Voorhees PM, Usmani SZ

Drug Design, Development and Therapy 2017, 11:893-900

Published Date: 20 March 2017

Delafloxacin: design, development and potential place in therapy

Candel FJ, Peñuelas M

Drug Design, Development and Therapy 2017, 11:881-891

Published Date: 20 March 2017

Artonin E induces p53-independent G1 cell cycle arrest and apoptosis through ROS-mediated mitochondrial pathway and livin suppression in MCF-7 cells

Etti IC, Rasedee A, Hashim NM, Abdul AB, Kadir A, Yeap SK, Waziri P, Malami I, Lim KL, Etti CJ

Drug Design, Development and Therapy 2017, 11:865-879

Published Date: 20 March 2017

Efficacy of cytokine-induced killer cell infusion as an adjuvant immunotherapy for hepatocellular carcinoma: a systematic review and meta-analysis

Yu R, Yang B, Chi X, Cai L, Liu C, Yang L, Wang X, He P, Lu X

Drug Design, Development and Therapy 2017, 11:851-864

Published Date: 17 March 2017

Cardioprotection with halogenated gases: how does it occur?

Guerrero-Orriach JL, Escalona Belmonte JJ, Ramirez Fernandez A, Ramirez Aliaga M, Rubio Navarro M, Cruz Mañas J

Drug Design, Development and Therapy 2017, 11:837-849

Published Date: 16 March 2017

Design, synthesis, and antimelanogenic effects of (2-substituted phenyl-1,3-dithiolan-4-yl)methanol derivatives

Kim DH, Kim SJ, Ullah S, Yun HY, Chun P, Moon HR

Drug Design, Development and Therapy 2017, 11:827-836

Published Date: 16 March 2017

Development of erythropoietin receptor-targeted drug delivery system against breast cancer using tamoxifen-loaded nanostructured lipid carriers

Beh CY, How CW, Foo JB, Foong JN, Selvarajah GT, Rasedee A

Drug Design, Development and Therapy 2017, 11:771-782

Published Date: 14 March 2017

Glycophenotype of breast and prostate cancer stem cells treated with thieno[2,3-b]pyridine anticancer compound

Mastelić A, Čikeš Čulić V, Režić Mužinić N, Vuica-Ross M, Barker D, Leung EY, Reynisson J, Markotić A

Drug Design, Development and Therapy 2017, 11:759-769

Published Date: 14 March 2017

An open-label, two-period comparative study on pharmacokinetics and safety of a combined ethinylestradiol/gestodene transdermal contraceptive patch

Zhang C, Li H, Xiong X, Zhai S, Wei Y, Zhang S, Zhang Y, Xu L, Liu L

Drug Design, Development and Therapy 2017, 11:725-731

Published Date: 10 March 2017

Pharmacokinetics and tolerability of DA-8031, a novel selective serotonin reuptake inhibitor for premature ejaculation in healthy male subjects

Shin D, Lee S, Yi S, Yoon SH, Cho JY, Bahng MY, Jang IJ, Yu KS

Drug Design, Development and Therapy 2017, 11:713-723

Published Date: 10 March 2017

Effects of dexamethasone coadministered with oseltamivir on the pharmacokinetics of oseltamivir in healthy volunteers

Jang K, Kim M, Oh J, Lee S, Cho JY, Yu KS, Choi TK, Lee SH, Lim KS

Drug Design, Development and Therapy 2017, 11:705-711

Published Date: 9 March 2017

Transcriptome analysis of endometrial tissues following GnRH agonist treatment in a mouse adenomyosis model

Guo S, Lu X, Gu R, Zhang D, Sun Y, Feng Y

Drug Design, Development and Therapy 2017, 11:695-704

Published Date: 9 March 2017

Development of venetoclax for therapy of lymphoid malignancies

Zhu H, Almasan A

Drug Design, Development and Therapy 2017, 11:685-694

Published Date: 9 March 2017

Does remifentanil attenuate renal ischemia–reperfusion injury better than dexmedetomidine in rat kidney?

Erkılıç E, Kesimci E, Alaybeyoğlu F, Kılınç I, Tural R, Yazgan A, Gümüş T, Sepici Dinçel A, Dumlu EG, Kanbak O

Drug Design, Development and Therapy 2017, 11:677-683

Published Date: 8 March 2017

Protective influence of hyaluronic acid on focal adhesion kinase activity in human skin fibroblasts exposed to ethanol

Donejko M, Rysiak E, Galicka E, Terlikowski R, Głażewska EK, Przylipiak A

Drug Design, Development and Therapy 2017, 11:669-676

Published Date: 6 March 2017

Paclitaxel-loaded star-shaped copolymer nanoparticles for enhanced malignant melanoma chemotherapy against multidrug resistance

Su Y, Hu J, Huang Z, Huang Y, Peng B, Xie N, Liu H

Drug Design, Development and Therapy 2017, 11:659-668

Published Date: 6 March 2017

New developments in the management of partial-onset epilepsy: role of brivaracetam

Coppola G, Iapadre G, Operto FF, Verrotti A

Drug Design, Development and Therapy 2017, 11:643-657

Published Date: 6 March 2017

MC-PPEA as a new and more potent inhibitor of CLP-induced sepsis and pulmonary inflammation than FK866

Huang P, Lee Jr MW, Sadrerafi K, Heruth DP, Zhang LQ, Maulik D, Ye SQ

Drug Design, Development and Therapy 2017, 11:629-641

Published Date: 3 March 2017

Metal complexes in cancer therapy – an update from drug design perspective

Ndagi U, Mhlongo N, Soliman ME

Drug Design, Development and Therapy 2017, 11:599-616

Published Date: 3 March 2017

Awake craniotomy anesthetic management using dexmedetomidine, propofol, and remifentanil

Prontera A, Baroni S, Marudi A, Valzania F, Feletti A, Benuzzi F, Bertellini E, Pavesi G

Drug Design, Development and Therapy 2017, 11:593-598

Published Date: 3 March 2017

Human papillomavirus (HPV): systemic treatment with Gene-Eden-VIR/Novirin safely and effectively clears virus

Polansky H, Itzkovitz E, Javaherian A

Drug Design, Development and Therapy 2017, 11:575-583

Published Date: 3 March 2017

In silico discovery and in vitro activity of inhibitors against Mycobacterium tuberculosis 7,8-diaminopelargonic acid synthase (Mtb BioA)

Billones JB, Carrillo MCO, Organo VG, Sy JBA, Clavio NAB, Macalino SJY, Emnacen IA, Lee AP, Ko PKL, Concepcion GP

Drug Design, Development and Therapy 2017, 11:563-574

Published Date: 2 March 2017

Adenosine A2A  receptor agonist prevents cardiac remodeling and dysfunction in spontaneously hypertensive male rats after myocardial infarction

da Silva JS, Gabriel-Costa D, Sudo RT, Wang H, Groban L, Ferraz EB, Nascimento JHM, Fraga CAM, Barreiro EJ, Zapata-Sudo G

Drug Design, Development and Therapy 2017, 11:553-562

Published Date: 6 March 2017

Defective DNA repair mechanisms in prostate cancer: impact of olaparib

De Felice F, Tombolini V, Marampon F, Musella A, Marchetti C

Drug Design, Development and Therapy 2017, 11:547-552

Published Date: 1 March 2017

Eteplirsen in the treatment of Duchenne muscular dystrophy

Lim KRQ, Maruyama R, Yokota T

Drug Design, Development and Therapy 2017, 11:533-545

Published Date: 28 February 2017

Sofosbuvir/velpatasvir regimen promises an effective pan-genotypic hepatitis C virus cure

Mir F, Kahveci AS, Ibdah JA, Tahan V

Drug Design, Development and Therapy 2017, 11:497-502

Published Date: 23 February 2017

Polyphosphoester nanoparticles as biodegradable platform for delivery of multiple drugs and siRNA

Elzeny H, Zhang F, Ali EN, Fathi HA, Zhang S, Li R, El-Mokhtar MA, Hamad MA, Wooley KL, Elsabahy M

Drug Design, Development and Therapy 2017, 11:483-496

Published Date: 22 February 2017

Antiproliferation effect of imatinib mesylate on MCF7, T-47D tumorigenic and MCF 10A nontumorigenic breast cell lines via PDGFR-β, PDGF-BB, c-Kit and SCF genes

Kadivar A, Kamalidehghan B, Akbari Javar H, Karimi B, Sedghi R, Noordin MI

Drug Design, Development and Therapy 2017, 11:469-481

Published Date: 21 February 2017

Insight into resistance mechanisms of AZD4547 and E3810 to FGFR1 gatekeeper mutation via theoretical study

Liang D, Chen Q, Guo Y, Zhang T, Guo W

Drug Design, Development and Therapy 2017, 11:451-461

Published Date: 17 February 2017

Reversal of multidrug resistance in human lung cancer cells by delivery of 3-octadecylcarbamoylacrylic acid–cisplatin-based liposomes

Song J, Ren W, Xu T, Zhang Y, Guo H, Zhu S, Yang L

Drug Design, Development and Therapy 2017, 11:441-449

Published Date: 17 February 2017

Curcumin induces apoptosis and protective autophagy in castration-resistant prostate cancer cells through iron chelation

Yang C, Ma X, Wang Z, Zeng X, Hu Z, Ye Z, Shen G

Drug Design, Development and Therapy 2017, 11:431-439

Published Date: 14 February 2017

Novel 5-oxo-hexahydroquinoline derivatives: design, synthesis, in vitro P-glycoprotein-mediated multidrug resistance reversal profile and molecular dynamics simulation study

Shahraki O, Edraki N, Khoshneviszadeh M, Zargari F, Ranjbar S, Saso L, Firuzi O, Miri R

Drug Design, Development and Therapy 2017, 11:407-418

Published Date: 14 February 2017

Oral and transdermal drug delivery systems: role of lipid-based lyotropic liquid crystals

Rajabalaya R, Musa MN, Kifli N, David SR

Drug Design, Development and Therapy 2017, 11:393-406

Published Date: 13 February 2017

Antioxidant compounds and activities of the stem, flower, and leaf extracts of the anti-smoking Thai medicinal plant: Vernonia cinerea Less

Ketsuwan N, Leelarungrayub J, Kothan S, Singhatong S

Drug Design, Development and Therapy 2017, 11:383-391

Published Date: 13 February 2017

Pharmacokinetics of conivaptan use in patients with severe hepatic impairment

Marbury T, Fox J, Kaelin B, Pavliv L

Drug Design, Development and Therapy 2017, 11:373-382

Published Date: 13 February 2017

Gancidin W, a potential low-toxicity antimalarial agent isolated from an endophytic Streptomyces SUK10

Zin NM, Baba MS, Zainal-Abidin AH, Latip J, Mazlan NW, Edrada-Ebel R

Drug Design, Development and Therapy 2017, 11:351-363

Published Date: 8 February 2017

Kelussia odoratissima Mozaff. activates intrinsic pathway of apoptosis in breast cancer cells associated with S phase cell cycle arrest via involvement of p21/p27 in vitro and in vivo

Karimian H, Arya A, Fadaeinasab M, Razavi M, Hajrezaei M, Karim Khan A, Mohd Ali H, Abdulla MA, Noordin MI

Drug Design, Development and Therapy 2017, 11:337-350

Published Date: 1 February 2017

Drug delivery in overcoming the blood–brain barrier: role of nasal mucosal grafting

Marianecci C, Rinaldi F, Hanieh PN, Di Marzio L, Paolino D, Carafa M

Drug Design, Development and Therapy 2017, 11:325-335

Published Date: 27 January 2017

Phloretin exerts hypoglycemic effect in streptozotocin-induced diabetic rats and improves insulin resistance in vitro

Shen X, Zhou N, Mi L, Hu Z, Wang L, Liu X, Zhang S

Drug Design, Development and Therapy 2017, 11:313-324

Published Date: 7 February 2017

Obinutuzumab in chronic lymphocytic leukemia: design, development and place in therapy

Al-Sawaf O, Fischer K, Engelke A, Pflug N, Hallek M, Goede V

Drug Design, Development and Therapy 2017, 11:295-304

Published Date: 25 January 2017

Theophylline action on primary human bronchial epithelial cells under proinflammatory stimuli and steroidal drugs: a therapeutic rationale approach

Gallelli L, Falcone D, Cannataro R, Perri M, Serra R, Pelaia G, Maselli R, Savino R, Spaziano G, D’Agostino B

Drug Design, Development and Therapy 2017, 11:265-272

Published Date: 23 January 2017

Plitidepsin: design, development, and potential place in therapy

Alonso-Álvarez S, Pardal E, Sánchez-Nieto D, Navarro M, Caballero MD, Mateos MV, Martín A

Drug Design, Development and Therapy 2017, 11:253-264

Published Date: 19 January 2017

Effect of roll compaction on granule size distribution of microcrystalline cellulose–mannitol mixtures: computational intelligence modeling and parametric analysis

Kazemi P, Khalid MH, Pérez Gago A, Kleinebudde P, Jachowicz R, Szlęk J, Mendyk A

Drug Design, Development and Therapy 2017, 11:241-251

Published Date: 18 January 2017

N-(3-hydroxymethyl-β-carboline-1-yl-ethyl-2-yl)-L-Phe: development toward a nanoscaled antitumor drug capable of treating complicated thrombosis and inflammation

Wu JH, Zhao M, Wang YJ, Wang YN, Zhu HM, Zhao SR, Gui L, Zhang XY, Peng SQ

Drug Design, Development and Therapy 2017, 11:225-239

Published Date: 17 January 2017

Spotlight on mavrilimumab for the treatment of rheumatoid arthritis: evidence to date

Crotti C, Raimondo MG, Becciolini A, Biggioggero M, Favalli EG

Drug Design, Development and Therapy 2017, 11:211-223

Published Date: 13 January 2017

Comparison of the long-term efficacy and safety of generic Tacrobell with original tacrolimus (Prograf) in kidney transplant recipients

Son SY, Jang HR, Lee JE, Yoo H, Kim K, Park JB, Kim SJ, Oh HY, Huh W

Drug Design, Development and Therapy 2017, 11:203-210

Published Date: 12 January 2017

Computational intelligence models to predict porosity of tablets using minimum features

Khalid MH, Kazemi P, Perez-Gandarillas L, Michrafy A, Szlęk J, Jachowicz R, Mendyk A

Drug Design, Development and Therapy 2017, 11:193-202

Published Date: 12 January 2017

Evaluation of a 2-aminoimidazole variant as adjuvant treatment for dermal bacterial infections

Draughn GL, Allen CL, Routh PA, Stone MR, Kirker KR, Boegli L, Schuchman RM, Linder KE, Baynes RE, James G, Melander C, Pollard A, Cavanagh J

Drug Design, Development and Therapy 2017, 11:153-162

Published Date: 11 January 2017

Pharmacokinetic and pharmacodynamic evaluation according to absorption differences in three formulations of ibuprofen

Shin D, Lee SJ, Ha Y, Choi YS, Kim JW, Park SR, Park MK

Drug Design, Development and Therapy 2017, 11:135-141

Published Date: 4 January 2017

A triazole derivative elicits autophagic clearance of polyglutamine aggregation in neuronal cells [Corrigendum]

Hsieh CH, Lee LC, Leong WY, Yang TC, Yao CF, Fang K

Drug Design, Development and Therapy 2017, 11:133-134

Published Date: 28 December 2016

Effects of multiple-dose ponesimod, a selective S1P1 receptor modulator, on lymphocyte subsets in healthy humans

Jurcevic S, Juif PE, Hamid C, Greenlaw R, D'Ambrosio D, Dingemanse J

Drug Design, Development and Therapy 2017, 11:123-131

Published Date: 28 December 2016

Anticancer and anti-inflammatory activities of girinimbine isolated from Murraya koenigii

Iman V, Mohan S, Abdelwahab SI, Karimian H, Nordin N, Fadaeinasab M, Noordin MI, Noor SM

Drug Design, Development and Therapy 2017, 11:103-121

Published Date: 28 December 2016

Vitamin D deficiency and the risk of tuberculosis: a meta-analysis

Huang SJ, Wang XH, Liu ZD, Cao WL, Han Y, Ma AG, Xu SF

Drug Design, Development and Therapy 2017, 11:91-102

Published Date: 28 December 2016

Analysis of pramipexole dose–response relationships in Parkinson's disease

Wang Y, Sun SG, Zhu SQ, Liu CF, Liu YM, Di Q, Shang HF, Ren Y, Xiang W, Chen SD

Drug Design, Development and Therapy 2017, 11:83-89

Published Date: 23 December 2016

Development of a chitosan based double layer-coated tablet as a platform for colon-specific drug delivery

Kim MS, Yeom DW, Kim SR, Yoon HY, Kim CH, Son HY, Kim JH, Lee S, Choi YW

Drug Design, Development and Therapy 2017, 11:45-57

Published Date: 21 December 2016

Spotlight on the 9-valent HPV vaccine

Lopalco PL

Drug Design, Development and Therapy 2017, 11:35-44

Published Date: 20 December 2016

Gastroretentive behavior of orally administered radiolabeled tamarind seed formulations in rabbits validated by gamma scintigraphy

Razavi M, Karimian H, Yeong CH, Fadaeinasab M, Khaing SL, Chung LY, Mohamad Haron DE, Noordin MI

Drug Design, Development and Therapy 2017, 11:1-15

Published Date: 19 December 2016