Kabat-Koperska J, Kolasa-Wołosiuk A, Wojciuk B, Wojciechowska-Koszko I, Roszkowska P, Krasnodębska-Szponder B, Paczkowska E, Safranow K, Gołembiewska E, Machaliński B, Ciechanowski K

Drug Design, Development and Therapy 2016, 10:2279-2288

Published Date: 14 July 2016

Original Research

Simvastatin attenuates radiation-induced salivary gland dysfunction in mice

Xu L, Yang X, Chen J, Ge X, Qin Q, Zhu H, Zhang C, Sun X

Drug Design, Development and Therapy 2016, 10:2271-2278

Published Date: 13 July 2016

Review

Sitagliptin/metformin fixed-dose combination in type 2 diabetes mellitus: an evidence-based review of its place in therapy

Hayes J, Anderson R, Stephens JW

Drug Design, Development and Therapy 2016, 10:2263-2270

Published Date: 19 July 2016

Review

An appraisal of golimumab in the treatment of severe, active nonradiographic axial spondyloarthritis

Paccou J, Flipo RM

Drug Design, Development and Therapy 2016, 10:2255-2262

Published Date: 11 July 2016

Original Research

Thymoquinone subdues tumor growth and potentiates the chemopreventive effect of 5-fluorouracil on the early stages of colorectal carcinogenesis in rats

Kensara OA, El-Shemi AG, Mohamed AM, Refaat B, Idris S, Ahmad J

Drug Design, Development and Therapy 2016, 10:2239-2253

Published Date: 11 July 2016

Original Research

Puerarin transport across a Calu-3 cell monolayer – an in vitro model of nasal mucosa permeability and the influence of paeoniflorin and menthol

Zhang L, Du SY, Lu Y, Liu C, Tian ZH, Yang C, Wu HC, Wang Z

Drug Design, Development and Therapy 2016, 10:2227-2237

Published Date: 8 July 2016

Original Research

Pharmacogenetic analysis of cinacalcet response in secondary hyperparathyroidism patients

Jeong S, Kim IW, Oh KH, Han N, Joo KW, Kim HJ, Oh JM

Drug Design, Development and Therapy 2016, 10:2211-2225

Published Date: 8 July 2016

Original Research

Acyl lipidation of a peptide: effects on activity and epidermal permeability in vitro

Rocco D, Ross J, Murray PE, Caccetta R

Drug Design, Development and Therapy 2016, 10:2203-2209

Published Date: 8 July 2016

Original Research

Rosmarinic acid ameliorates hyperglycemia and insulin sensitivity in diabetic rats, potentially by modulating the expression of PEPCK and GLUT4

Runtuwene J, Cheng KC, Asakawa A, Amitani H, Amitani M, Morinaga A, Takimoto Y, Kairupan BHR, Inui A

Drug Design, Development and Therapy 2016, 10:2193-2202

Published Date: 7 July 2016

Original Research

Effect of N-methyl deuteration on metabolism and pharmacokinetics of enzalutamide

Jiang J, Pang X, Li L, Dai X, Diao X, Chen X, Zhong D, Wang Y, Chen Y

Drug Design, Development and Therapy 2016, 10:2181-2191

Published Date: 7 July 2016

Original Research

The effects of ferulic acid on the pharmacokinetics of warfarin in rats after biliary drainage

Li H, Wang Y, Fan R, Lv H, Sun H, Xie H, Tang T, Luo J, Xia Z

Drug Design, Development and Therapy 2016, 10:2173-2180

Published Date: 6 July 2016

Review

Cabozantinib in the treatment of advanced renal cell carcinoma: design, development, and potential place in the therapy

Grassi P, Verzoni E, Ratta R, Mennitto A, de Braud F, Procopio G

Drug Design, Development and Therapy 2016, 10:2167-2172

Published Date: 5 July 2016

Original Research

Real-time monitoring of cisplatin cytotoxicity on three-dimensional spheroid tumor cells

Baek NH, Seo OW, Lee J, Hulme J, An SSA

Drug Design, Development and Therapy 2016, 10:2155-2165

Published Date: 4 July 2016

Original Research

Pharmacophore modeling and in silico toxicity assessment of potential anticancer agents from African medicinal plants

Ntie-Kang F, Simoben CV, Karaman B, Ngwa VF, Judson PN, Sippl W, Mbaze LM

Drug Design, Development and Therapy 2016, 10:2137-2154

Published Date: 4 July 2016

Original Research

Comparison of cisplatinum/paclitaxel with cisplatinum/5-fluorouracil as first-line therapy for nonsurgical locally advanced esophageal squamous cell carcinoma patients

Hu GF, Wang ZH, Wang Y, Zhang QQ, Tang N, Guo J, Liu LY, Han X

Drug Design, Development and Therapy 2016, 10:2129-2136

Published Date: 1 July 2016

Review

Spotlight on grazoprevir—elbasvir once-daily combination and its potential in the treatment of hepatitis C

Suraweera D, Weeratunga AN, Saab S

Drug Design, Development and Therapy 2016, 10:2119-2127

Published Date: 29 June 2016

Review

Clinical implications for substandard, nonproprietary medicines in multiple sclerosis: focus on fingolimod

Correale J, Chiquete E, Boyko A, Beran RG, Strauch JB, Milojevic S, Frider N

Drug Design, Development and Therapy 2016, 10:2109-2117

Published Date: 30 June 2016

Original Research

Sitagliptin attenuates cardiomyopathy by modulating the JAK/STAT signaling pathway in experimental diabetic rats

Al-Rasheed NM, Al-Rasheed NM, Hasan IH, Al-Amin MA, Al-Ajmi HN, Mahmoud AM

Drug Design, Development and Therapy 2016, 10:2095-2107

Published Date: 28 June 2016

Review

Golimumab in radiographic and nonradiographic axial spondyloarthritis: a review of clinical trials

Toussirot E, Vauchy C, Binda D, Michel F

Drug Design, Development and Therapy 2016, 10:2087-2094

Published Date: 1 July 2016

Original Research

Dietary arginine silicate inositol complex increased bone healing: histologic and histomorphometric study

Yaman F, Acikan I, Dundar S, Simsek S, Gul M, Ozercan İH, Komorowski J, Sahin K

Drug Design, Development and Therapy 2016, 10:2081-2086

Published Date: 27 June 2016

Review

Secukinumab for rheumatology: development and its potential place in therapy

Koenders MI, van den Berg WB

Drug Design, Development and Therapy 2016, 10:2069-2080

Published Date: 24 June 2016

Original Research

The cytotoxicity study of praziquantel enantiomers

Sun Q, Mao RF, Wang DL, Hu CY, Zheng Y, Sun DQ

Drug Design, Development and Therapy 2016, 10:2061-2068

Published Date: 24 June 2016

Original Research

Design and optimization of self-nanoemulsifying drug delivery systems for improved bioavailability of cyclovirobuxine D

Ke ZC, Hou XF, Jia XB

Drug Design, Development and Therapy 2016, 10:2049-2060

Published Date: 28 June 2016

Letter

Anti-dengue drug: viral polyprotein, a potential target

Mahmood SU, Mushtaq M, Syed MJ

Drug Design, Development and Therapy 2016, 10:2047-2048

Published Date: 24 June 2016

Original Research

Fondaparinux vs warfarin for the treatment of unsuspected pulmonary embolism in cancer patients

Amato B, Compagna R, Rocca A, Bianco T, Milone M, Sivero L, Vigliotti G, Amato M, Danzi M, Aprea G, Gallelli L, de Franciscis S, Serra R

Drug Design, Development and Therapy 2016, 10:2041-2046

Published Date: 23 June 2016

Original Research

Enhanced oral bioavailability of acetylpuerarin by poly(lactide-co-glycolide) nanoparticles optimized using uniform design combined with response surface methodology

Sun D, Xue A, Zhang B, Xue X, Zhang J, Liu W

Drug Design, Development and Therapy 2016, 10:2029-2039

Published Date: 21 June 2016

Original Research

A novel pH–enzyme-dependent mesalamine colon-specific delivery system

Jin L, Ding Y, Zhang Y, Xu X, Cao Q

Drug Design, Development and Therapy 2016, 10:2021-2028

Published Date: 20 June 2016

Review

Position and enforcement practice of the People's Republic of China's pharmaceutical data exclusivity protection

Li N, Yu X, Pecht M

Drug Design, Development and Therapy 2016, 10:2015-2020

Published Date: 22 June 2016

Original Research

The aqueous extract of Chinese medicinal herb Brucea javanica suppresses the growth of human liver cancer and the derived stem-like cells by apoptosis

Chen JH, Kim SH, Fan PW, Liu CY, Hsieh CH, Fang K

Drug Design, Development and Therapy 2016, 10:2003-2013

Published Date: 17 June 2016

Original Research

MART-10, a newly synthesized vitamin D analog, represses metastatic potential of head and neck squamous carcinoma cells

Yang SW, Tsai CY, Pan YC, Yeh CN, Pang JHS, Takano M, Kittaka A, Juang HH, Chen TC, Chiang KC

Drug Design, Development and Therapy 2016, 10:1995-2002

Published Date: 17 June 2016

Original Research

Double-blind, randomized, double-dummy clinical trial comparing the efficacy of ketorolac trometamol and naproxen for acute low back pain

Plapler PG, Scheinberg MA, Ecclissato CC, Bocchi de Oliveira MF, Amazonas RB

Drug Design, Development and Therapy 2016, 10:1987-1993

Published Date: 17 June 2016

Original Research

Prophylactic effects of Clausena excavata Burum. f. leaf extract in ethanol-induced gastric ulcers

Albaayit SFA, Abba Y, Abdullah R, Abdullah N

Drug Design, Development and Therapy 2016, 10:1973-1986

Published Date: 15 June 2016

Original Research

Efficacy and safety of gemcitabine plus erlotinib for locally advanced or metastatic pancreatic cancer: a systematic review and meta-analysis

Wang Y, Hu GF, Zhang QQ, Tang N, Guo J, Liu LY, Han X, Wang X, Wang ZH

Drug Design, Development and Therapy 2016, 10:1961-1972

Published Date: 13 June 2016

Original Research

A novel imidazopyridine derivative, X22, attenuates sepsis-induced lung and liver injury by inhibiting the inflammatory response in vitro and in vivo

Ge X, Feng Z, Xu T, Wu B, Chen H, Xu F, Fu L, Shan X, Dai Y, Zhang Y, Liang G

Drug Design, Development and Therapy 2016, 10:1947-1959

Published Date: 24 June 2016

Original Research

Inhibitory effects of compounds from Phyllanthus amarus on nitric oxide production, lymphocyte proliferation, and cytokine release from phagocytes

Yuandani, Jantan I, Ilangkovan M, Husain K, Chan KM

Drug Design, Development and Therapy 2016, 10:1935-1945

Published Date: 9 June 2016

Original Research

The efficacy of nebulized magnesium sulfate alone and in combination with salbutamol in acute asthma

Sarhan HA, EL-Garhy OH, Ali MA, Youssef NA

Drug Design, Development and Therapy 2016, 10:1927-1933

Published Date: 9 June 2016

Original Research

In vivo gastric residence and gastroprotective effect of floating gastroretentive tablet of DA-9601, an extract of Artemisia asiatica, in beagle dogs

Kim JS, Cha KH, Kang SY, Won D, Jang SW, Son M, Son MH, Choi HJ, Lee YW, Kang MJ

Drug Design, Development and Therapy 2016, 10:1917-1925

Published Date: 9 June 2016

Original Research

Role of cytochrome P450 2D6 genetic polymorphism in carvedilol hydroxylation in vitro

Wang Z, Wang L, Xu RA, Zhan YY, Huang CK, Dai DP, Cai JP, Hu GX

Drug Design, Development and Therapy 2016, 10:1909-1916

Published Date: 8 June 2016

Original Research

Flavokawain derivative FLS induced G2/M arrest and apoptosis on breast cancer MCF-7 cell line

Ali NM, Akhtar MN, Ky H, Lim KL, Abu N, Zareen S, Ho WY, Alan-Ong HK, Tan SW, Alitheen NB, Ismail JB, Yeap SK, Kamarul T

Drug Design, Development and Therapy 2016, 10:1897-1907

Published Date: 10 June 2016

Review

Molecular mechanisms of cisplatin resistance in cervical cancer

Zhu H, Luo H, Zhang W, Shen Z, Hu X, Zhu X

Drug Design, Development and Therapy 2016, 10:1885-1895

Published Date: 7 June 2016

Original Research

Erythropoietin ameliorates hyperglycemia in type 1-like diabetic rats

Niu HS, Chang CH, Niu CS, Cheng JT, Lee KS

Drug Design, Development and Therapy 2016, 10:1877-1884

Published Date: 3 June 2016

Original Research

Stability of tramadol with three 5-HT3 receptor antagonists in polyolefin bags for patient-controlled delivery systems

Chen FC, Zhu J, Li B, Yuan FJ, Wang LH

Drug Design, Development and Therapy 2016, 10:1869-1875

Published Date: 3 June 2016

Review

Resistance to anti-VEGF therapy in neovascular age-related macular degeneration: a comprehensive review

Yang S, Zhao J, Sun X

Drug Design, Development and Therapy 2016, 10:1857-1867

Published Date: 2 June 2016

Original Research

Indigofera oblongifolia mitigates lead-acetate-induced kidney damage and apoptosis in a rat model

Dkhil MA, Al-Khalifa MS, Al-Quraishy S, Zrieq R, Abdel Moneim AE

Drug Design, Development and Therapy 2016, 10:1847-1856

Published Date: 2 June 2016

Original Research

Nelfinavir is effective against human cervical cancer cells in vivo: a potential treatment modality in resource-limited settings

Davis MA, Delaney JR, Patel CB, Storgard R, Stupack DG

Drug Design, Development and Therapy 2016, 10:1837-1846

Published Date: 2 June 2016

Original Research

Anti-inflammatory effects of guggulsterone on murine macrophage by inhibiting LPS-induced inflammatory cytokines in NF-κB signaling pathway

Zhang JH, Shangguan ZS, Chen C, Zhang HJ, Lin Y

Drug Design, Development and Therapy 2016, 10:1829-1835

Published Date: 1 June 2016

Original Research

Isolation and characterization of cyclo-(tryptophanyl-prolyl) and chloramphenicol from Streptomyces sp. SUK 25 with antimethicillin-resistant Staphylococcus aureus activity

Alshaibani MM, Jalil J, Sidik NM, Edrada-Ebel R, Zin NM

Drug Design, Development and Therapy 2016, 10:1817-1827

Published Date: 31 May 2016

Original Research

Synthesis, activity, and docking study of phenylthiazole acids as potential agonists of PPARγ

Ma L, Wang T, Shi M, Ye H

Drug Design, Development and Therapy 2016, 10:1807-1815

Published Date: 30 May 2016

Review

The arsenal of pathogens and antivirulence therapeutic strategies for disarming them

Brannon JR, Hadjifrangiskou M

Drug Design, Development and Therapy 2016, 10:1795-1806

Published Date: 27 May 2016

Original Research

Efficacy of α-blocker in improving ureteral stent-related symptoms: a meta-analysis of both direct and indirect comparison

He F, Man LB, Li GZ, Liu N

Drug Design, Development and Therapy 2016, 10:1783-1793

Published Date: 26 May 2016

Original Research

An open-label clinical trial of agalsidase alfa enzyme replacement therapy in children with Fabry disease who are naïve to enzyme replacement therapy

Goker-Alpan O, Longo N, McDonald M, Shankar SP, Schiffmann R, Chang P, Shen Y, Pano A

Drug Design, Development and Therapy 2016, 10:1771-1781

Published Date: 25 May 2016

Review

Apremilast in the therapy of moderate-to-severe chronic plaque psoriasis

Gisondi P, Girolomoni G

Drug Design, Development and Therapy 2016, 10:1763-1770

Published Date: 25 May 2016

Original Research

Activity of a novel sulfonamide compound 2-nitro-N-(pyridin-2-ylmethyl)benzenesulfonamide against Leishmania donovani

Dikhit MR, Purkait B, Singh R, Sahoo BR, Kumar A, Kar RK, Ansari MY, Saini S, Abhishek K, Sahoo GC, Das S, Das P

Drug Design, Development and Therapy 2016, 10:1753-1761

Published Date: 26 May 2016

Original Research

Sulfasalazine inhibits inflammation and fibrogenesis in pancreas via NF-κB signaling pathway in rats with oxidative stress-induced pancreatic injury

Wang YR, Tian FL, Yan MX, Fan JH, Wang LY, Kuang RG, Li YQ

Drug Design, Development and Therapy 2016, 10:1743-1751

Published Date: 24 May 2016

Review

Critical appraisal of 3-monthly paliperidone depot injections in the treatment of schizophrenia

Carpiniello B, Pinna F

Drug Design, Development and Therapy 2016, 10:1731-1742

Published Date: 24 May 2016

Original Research

Evaluation of wound healing properties of bioactive aqueous fraction from Moringa oleifera Lam on experimentally induced diabetic animal model

Muhammad AA, Arulselvan P, Cheah PS, Abas F, Fakurazi S

Drug Design, Development and Therapy 2016, 10:1715-1730

Published Date: 24 May 2016

Original Research

Computer-aided vaccine designing approach against fish pathogens Edwardsiella tarda and Flavobacterium columnare using bioinformatics softwares

Mahendran R, Jeyabaskar S, Sitharaman G, Michael RD, Paul AV

Drug Design, Development and Therapy 2016, 10:1703-1714

Published Date: 23 May 2016

Original Research

Electroporation-delivered transdermal neostigmine in rats: equivalent action to intravenous administration

Berkó S, Szűcs KF, Balázs B, Csányi E, Varju G, Sztojkov-Ivanov A, Budai-Szűcs M, Bóta J, Gáspár R

Drug Design, Development and Therapy 2016, 10:1695-1701

Published Date: 19 May 2016

Original Research

Reducing the trigger dose of recombinant hCG in high-responder patients attending an assisted reproductive technology program: an observational study

Tiboni GM, Colangelo EC, Ponzano A

Drug Design, Development and Therapy 2016, 10:1691-1694

Published Date: 18 May 2016

Review

Spotlight on idarucizumab and its potential for the reversal of anticoagulant effects of dabigatran

Sié P

Drug Design, Development and Therapy 2016, 10:1683-1689

Published Date: 18 May 2016

Review

Safety, efficacy, and clinical utility of macitentan in the treatment of pulmonary arterial hypertension

Monaco TJ, Davila CD

Drug Design, Development and Therapy 2016, 10:1675-1682

Published Date: 18 May 2016

Original Research

Ursolic acid reduces the metalloprotease/anti-metalloprotease imbalance in cerebral ischemia and reperfusion injury

Wang Y, He Z, Deng S

Drug Design, Development and Therapy 2016, 10:1663-1674

Published Date: 17 May 2016

Original Research

The combination of blueberry juice and probiotics reduces apoptosis of alcoholic fatty liver of mice by affecting SIRT1 pathway

Zhu J, Ren T, Zhou M, Cheng M,

Drug Design, Development and Therapy 2016, 10:1649-1661

Published Date: 12 May 2016

Review

Spotlight on brexpiprazole and its potential in the treatment of schizophrenia and as adjunctive therapy for the treatment of major depression

Bruijnzeel D, Tandon R

Drug Design, Development and Therapy 2016, 10:1641-1647

Published Date: 11 May 2016

Review

Spotlight on valsartan–sacubitril fixed-dose combination for heart failure: the evidence to date

Vilela-Martin JF

Drug Design, Development and Therapy 2016, 10:1627-1639

Published Date: 9 May 2016

Original Research

Safety, tolerability, pharmacokinetics, and pharmacodynamics of novel glucokinase activator HMS5552: results from a first-in-human single ascending dose study

Xu HR, Sheng L, Chen WL, Yuan F, Yang MJ, Li H, Li XN, Choi J, Zhao GY, Hu TX, Li YG, Zhang Y, Chen L

Drug Design, Development and Therapy 2016, 10:1619-1626

Published Date: 9 May 2016

Original Research

Pharmacoinformatic and molecular docking studies reveal potential novel antidepressants against neurodegenerative disorders by targeting HSPB8

Sehgal SA, Mannan S, Ali S

Drug Design, Development and Therapy 2016, 10:1605-1618

Published Date: 6 May 2016

Clinical Trial Report

Effectiveness, durability, and safety of darunavir/ritonavir in HIV-1-infected patients in routine clinical practice in Italy: a postauthorization noninterventional study

Antinori A, Meraviglia P, d’Arminio Monforte A, Castagna A, Mussini C, Bini T, Gianotti N, Rusconi S, Colella E, Airoldi G, Mancusi D, Termini R

Drug Design, Development and Therapy 2016, 10:1589-1603

Published Date: 6 May 2016

Original Research

Spirolactone provides protection from renal fibrosis by inhibiting the endothelial–mesenchymal transition in isoprenaline-induced heart failure in rats

Zhou H, Xi D, Liu J, Zhao J, Chen S, Guo Z

Drug Design, Development and Therapy 2016, 10:1581-1588

Published Date: 5 May 2016

Original Research

Fimasartan for independent reduction of blood pressure variability in mild-to-moderate hypertension

Shin MS, Kang DR, Kim C, Cho EJ, Sung KC, Kang SM, Kim DS, Joo SJ, Lee SH, Hwang KK, Park JB

Drug Design, Development and Therapy 2016, 10:1573-1580

Published Date: 5 May 2016

Original Research

Simultaneous targeting of MyD88 and Nur77 as an effective approach for the treatment of inflammatory diseases

Uzma S, Baig MS

Drug Design, Development and Therapy 2016, 10:1557-1572

Published Date: 4 May 2016

Original Research

Fungistatic activity of all-trans retinoic acid against Aspergillus fumigatus and Candida albicans

Campione E, Gaziano R, Marino D, Orlandi A

Drug Design, Development and Therapy 2016, 10:1551-1555

Published Date: 29 April 2016

Corrigendum

Zolav®: a new antibiotic for the treatment of acne [Corrigendum]

Dinant A, Boulos RA

Drug Design, Development and Therapy 2016, 10:1549-1550

Published Date: 29 April 2016

Corrigendum

Efficacy and safety of different doses of a slow-release corticosteroid implant for macular edema [Corrigendum]

Liu QY, He MM, Shi H, Wang QY, Du YR, Liu JL, Ren CD, Xu D, Yu J

Drug Design, Development and Therapy 2016, 10:1547-1548

Published Date: 27 April 2016

Letter

Efficacy and safety of different doses of a slow release corticosteroid implant for macular edema

Hall J

Drug Design, Development and Therapy 2016, 10:1543-1546

Published Date: 20 April 2016

Original Research

Effects of a novel ACE inhibitor, 3-(3-thienyl)-L-alanyl-ornithyl-proline, on endothelial vasodilation and hepatotoxicity in L-NAME-induced hypertensive rats

Seth MK, Hussain ME, Pasha S, Fahim M

Drug Design, Development and Therapy 2016, 10:1533-1542

Published Date: 20 April 2016

Original Research

The influence of dietary sodium content on the pharmacokinetics and pharmacodynamics of fimasartan

Gu N, Cho JY, Shin KH, Jang IJ, Rhee MY

Drug Design, Development and Therapy 2016, 10:1525-1531

Published Date: 19 April 2016

Original Research

Long-term efficacy and safety of oxycodone–naloxone prolonged release in geriatric patients with moderate-to-severe chronic noncancer pain: a 52-week open-label extension phase study

Guerriero F, Roberto A, Greco MT, Sgarlata C, Rollone M, Corli O

Drug Design, Development and Therapy 2016, 10:1515-1523

Published Date: 19 April 2016

Original Research

Autophagy inhibition enhances RAD001-induced cytotoxicity in human bladder cancer cells

Lin JF, Lin YC, Yang SC, Tsai TF, Chen HE, Chou KY, Hwang TIS

Drug Design, Development and Therapy 2016, 10:1501-1513

Published Date: 18 April 2016

Original Research

Design, synthesis, and biological evaluation of 3-vinyl-quinoxalin-2(1H)-one derivatives as novel antitumor inhibitors of FGFR1

Liu Z, Yu S, Chen D, Shen G, Wang Y, Hou L, Lin D, Zhang JS, Ye F

Drug Design, Development and Therapy 2016, 10:1489-1500

Published Date: 3 May 2016

Original Research

Pirfenidone inhibits fibrosis in foreign body reaction after glaucoma drainage device implantation

Jung KI, Park CK

Drug Design, Development and Therapy 2016, 10:1477-1488

Published Date: 15 April 2016

Case report

Possible association between acetazolamide administration during pregnancy and multiple congenital malformations

Al-Saleem AI, Al-Jobair AM

Drug Design, Development and Therapy 2016, 10:1471-1476

Published Date: 15 April 2016

Original Research

Neuroprotective effect of β-asarone against Alzheimer’s disease: regulation of synaptic plasticity by increased expression of SYP and GluR1

Liu SJ, Yang C, Zhang Y, Su RY, Chen JL, Jiao MM, Chen HF, Zheng N, Luo S, Chen YB, Quan SJ, Wang Q

Drug Design, Development and Therapy 2016, 10:1461-1469

Published Date: 15 April 2016

Original Research

Zoledronate upregulates MMP-9 and -13 in rat vascular smooth muscle cells by inducing oxidative stress

Arun MZ, Reel B, Sala-Newby GB, Bond M, Tsaousi A, Maskell P, Newby AC

Drug Design, Development and Therapy 2016, 10:1453-1460

Published Date: 18 April 2016

Original Research

Xyloketal-derived small molecules show protective effect by decreasing mutant Huntingtin protein aggregates in Caenorhabditis elegans model of Huntington’s disease

Zeng YX, Guo WY, Xu GQ, Wang QM, Feng LY, Long SM, Liang FY, Huang Y, Lu XL, Li SC, Zhou JB, Burgunder JM, Pang JY, Pei Z

Drug Design, Development and Therapy 2016, 10:1443-1451

Published Date: 13 April 2016

Original Research

Baicalein suppresses metastasis of breast cancer cells by inhibiting EMT via downregulation of SATB1 and Wnt/β-catenin pathway

Ma X, Yan W, Dai Z, Gao X, Ma Y, Xu Q, Jiang J, Zhang S

Drug Design, Development and Therapy 2016, 10:1419-1441

Published Date: 18 April 2016

Original Research

Pharmacokinetics of the evogliptin/metformin extended-release (5/1,000 mg) fixed-dose combination formulation compared to the corresponding loose combination, and food effect in healthy subjects

Rhee SJ, Lee S, Yoon SH, Cho JY, Jang IJ, Yu KS

Drug Design, Development and Therapy 2016, 10:1411-1418

Published Date: 13 April 2016

Original Research

Acetogenins from Annona muricata as potential inhibitors of antiapoptotic proteins: a molecular modeling study

Antony P, Vijayan R

Drug Design, Development and Therapy 2016, 10:1399-1410

Published Date: 13 April 2016

Original Research

Andrographolide inhibits growth of human T-cell acute lymphoblastic leukemia Jurkat cells by downregulation of PI3K/AKT and upregulation of p38 MAPK pathways

Yang T, Yao S, Zhang X, Guo Y

Drug Design, Development and Therapy 2016, 10:1389-1397

Published Date: 11 April 2016

Original Research

Functionalized D-form self-assembling peptide hydrogels for bone regeneration

He B, Ou Y, Zhou A, Chen S, Zhao W, Zhao J, Li H, Zhu Y, Zhao Z, Jiang D

Drug Design, Development and Therapy 2016, 10:1379-1388

Published Date: 11 April 2016

Original Research

Per-residue energy decomposition pharmacophore model to enhance virtual screening in drug discovery: a study for identification of reverse transcriptase inhibitors as potential anti-HIV agents

Cele FN, Ramesh M, Soliman ME

Drug Design, Development and Therapy 2016, 10:1365-1377

Published Date: 11 April 2016

Original Research

Multiple-unit tablet of probiotic bacteria for improved storage stability, acid tolerability, and in vivo intestinal protective effect

Park HJ, Lee GH, Jun J, Son M, Kang MJ

Drug Design, Development and Therapy 2016, 10:1355-1364

Published Date: 7 April 2016

Original Research

Clinicopathological significance and a potential drug target of RARβ in non-small-cell lung carcinoma: a meta-analysis and a systematic review

Song X, Shi K, Zhou SJ, Yu DP, Liu Z, Han Y

Drug Design, Development and Therapy 2016, 10:1345-1354

Published Date: 6 April 2016

Original Research

Neuroprotective effects of salidroside through PI3K/Akt pathway activation in Alzheimer’s disease models

Zhang B, Wang Y, Li H, Xiong R, Zhao Z, Chu X, Li Q, Sun S, Chen S

Drug Design, Development and Therapy 2016, 10:1335-1343

Published Date: 6 April 2016

Original Research

Optimized nano-transfersomal films for enhanced sildenafil citrate transdermal delivery: ex vivo and in vivo evaluation

Badr-Eldin SM, Ahmed OAA

Drug Design, Development and Therapy 2016, 10:1323-1333

Published Date: 5 April 2016

Original Research

Identification of new drug candidates against Borrelia burgdorferi using high-throughput screening

Pothineni VR, Wagh D, Babar MM, Inayathullah M, Solow-Cordero DE, Kim KM, Samineni AV, Parekh MB, Tayebi L, Rajadas J

Drug Design, Development and Therapy 2016, 10:1307-1322

Published Date: 1 April 2016

Original Research

In vitro and in vivo efficacy of afatinib as a single agent or in combination with gemcitabine for the treatment of nasopharyngeal carcinoma

Xue C, Tian Y, Zhang J, Zhao YY, Zhan JH, Fang WF, Zhang L

Drug Design, Development and Therapy 2016, 10:1299-1306

Published Date: 31 March 2016

Original Research

RETRACTED ARTICLE: A novel tetrandrine-loaded chitosan microsphere: characterization and in vivo evaluation

Guo KF, Cang J

Drug Design, Development and Therapy 2016, 10:1291-1298

Published Date: 30 March 2016

Original Research

Insulin sensitizer in prediabetes: a clinical study with DLBS3233, a combined bioactive fraction of Cinnamomum burmanii and Lagerstroemia speciosa

Manaf A, Tjandrawinata RR, Malinda D

Drug Design, Development and Therapy 2016, 10:1279-1289

Published Date: 29 March 2016

Original Research

Curcumin protects against myocardial infarction-induced cardiac fibrosis via SIRT1 activation in vivo and in vitro

Xiao J, Sheng X, Zhang X, Guo M, Ji X

Drug Design, Development and Therapy 2016, 10:1267-1277

Published Date: 29 March 2016

Original Research

Comparative efficacy of tamsulosin versus nifedipine for distal ureteral calculi: a meta-analysis

Wang H, Man LB, Huang GL, Li GZ, Wang JW

Drug Design, Development and Therapy 2016, 10:1257-1265

Published Date: 29 March 2016

Original Research

A small interfering RNA targeting vascular endothelial growth factor efficiently inhibits growth of VX2 cells and VX2 tumor model of hepatocellular carcinoma in rabbit by transarterial embolization-mediated siRNA delivery

Zou Y, Guo CG, Yang ZG, Sun JH, Zhang MM, Fu CY

Drug Design, Development and Therapy 2016, 10:1243-1255

Published Date: 24 March 2016

Original Research

Zolav®: a new antibiotic for the treatment of acne

Dinant A, Boulos RA

Drug Design, Development and Therapy 2016, 10:1235-1242

Published Date: 22 March 2016

Letter

The renoprotective effects of sulodexide

Olde Engberink RH, Vogt L

Drug Design, Development and Therapy 2016, 10:1233-1234

Published Date: 22 March 2016

Original Research

Role of glycogen synthase kinase-3β inhibitor AZD1080 in ovarian cancer

Chen S, Sun KX, Feng MX, Sang XB, Liu BL, Zhao Y

Drug Design, Development and Therapy 2016, 10:1225-1232

Published Date: 18 March 2016

Original Research

Regional differences in hepatitis C treatment with peginterferon and ribavirin in Japan: a retrospective cohort study

Ide K, Kawasaki Y, Yamada H, Masaki N

Drug Design, Development and Therapy 2016, 10:1217-1223

Published Date: 22 March 2016

Original Research

Effects of acute and chronic administration of neurosteroid dehydroepiandrosterone sulfate on neuronal excitability in mice

Svob Strac D, Vlainic J, Samardzic J, Erhardt J, Krsnik Z

Drug Design, Development and Therapy 2016, 10:1201-1215

Published Date: 21 March 2016

Original Research

Computational and nonglycosylated systems: a simpler approach for development of nanosized PEGylated proteins

Mirzaei H, Kazemi B, Bandehpour M, Shoari A, Asgary V, Ardestani MS, Madadkar-Sobhani A, Ahangari Cohan R

Drug Design, Development and Therapy 2016, 10:1193-1200

Published Date: 16 March 2016

Corrigendum

Sonodynamic effect of hematoporphyrin monomethyl ether on ligature-induced periodontitis in rats [Corrigendum]

Zhuang DS, Han JL, Bi LJ, Wang YP, Hao YR, Zhou Q, Cao WW

Drug Design, Development and Therapy 2016, 10:1191-1192

Published Date: 17 March 2016

Original Research

Selective CDK7 inhibition with BS-181 suppresses cell proliferation and induces cell cycle arrest and apoptosis in gastric cancer

Wang BY, Liu QY, Cao J, Chen JW, Liu ZS

Drug Design, Development and Therapy 2016, 10:1181-1189

Published Date: 16 March 2016

Original Research

Efficacy of BIBF 1120 or BIBF 1120 plus chemotherapy on nasopharyngeal carcinoma in vitro and in vivo

Xue C, Tian Y, Zhang J, Zhao Y, Zhan J, Fang W, Zhang L

Drug Design, Development and Therapy 2016, 10:1173-1180

Published Date: 15 March 2016

Review

Efficacy of nystatin for the treatment of oral candidiasis: a systematic review and meta-analysis

Lyu X, Zhao C, Yan ZM, Hua H

Drug Design, Development and Therapy 2016, 10:1161-1171

Published Date: 16 March 2016

Letter

Comments on a meta-analysis and systematic review of the clinicopathological significance of CDH1 in gastric cancer

Tu C, Yuan L, Zhou J

Drug Design, Development and Therapy 2016, 10:1159-1160

Published Date: 15 March 2016

Original Research

Toward antituberculosis drugs: in silico screening of synthetic compounds against Mycobacterium tuberculosis L,D-transpeptidase 2

Billones JB, Carrillo MCO, Organo VG, Macalino SJY, Sy JBA, Emnacen IA, Clavio NAB, Concepcion GP

Drug Design, Development and Therapy 2016, 10:1147-1157

Published Date: 11 March 2016

Original Research

Synthesis, antimicrobial, and antiproliferative activities of substituted phenylfuranylnicotinamidines

Youssef MM, Arafa RK, Ismail MA,

Drug Design, Development and Therapy 2016, 10:1133-1146

Published Date: 11 March 2016

Review

Selective use of sorafenib in the treatment of thyroid cancer

Pitoia F, Jerkovich F

Drug Design, Development and Therapy 2016, 10:1119-1131

Published Date: 11 March 2016

Review

Laquinimod in the treatment of multiple sclerosis: a review of the data so far

Thöne J, Linker RA

Drug Design, Development and Therapy 2016, 10:1111-1118

Published Date: 14 March 2016

Original Research

Formulation and clinical evaluation of silymarin pluronic-lecithin organogels for treatment of atopic dermatitis

Mady FM, Essa H, El-Ammawi T, Abdelkader H, Hussein AK

Drug Design, Development and Therapy 2016, 10:1101-1110

Published Date: 10 March 2016

Review

Spotlight on botulinum toxin and its potential in the treatment of stroke-related spasticity

Kaku M, Simpson DM

Drug Design, Development and Therapy 2016, 10:1085-1099

Published Date: 8 March 2016

Original Research

Protective effects of honokiol on ischemia/reperfusion injury of rat ovary: an experimental study

Yaman Tunc S, Agacayak E, Goruk NY, Icen MS, Turgut A, Alabalik U, Togrul C, Ekinci C, Ekinci A, Gul T

Drug Design, Development and Therapy 2016, 10:1077-1083

Published Date: 8 March 2016

Original Research

RGD(F/S/V)-Dex: towards the development of novel, effective, and safe glucocorticoids

Jiang X, Zhao M, Wang Y, Zhu H, Zhao S, Wu J, Song Y, Peng S

Drug Design, Development and Therapy 2016, 10:1059-1076

Published Date: 8 March 2016

Review

Efficacy and safety of modified-release prednisone in patients with rheumatoid arthritis

Krasselt M, Baerwald C

Drug Design, Development and Therapy 2016, 10:1047-1058

Published Date: 8 March 2016

Original Research

Chloroquine enhances the efficacy of cisplatin by suppressing autophagy in human adrenocortical carcinoma treatment

Qin L, Xu TY, Xia LL, Wang XJ, Zhang X, Zhang XH, Zhu ZW, Zhong S, Wang CD, Shen ZJ

Drug Design, Development and Therapy 2016, 10:1035-1045

Published Date: 7 March 2016

Original Research

Stability studies of lincomycin hydrochloride in aqueous solution and intravenous infusion fluids

Czarniak P, Boddy M, Sunderland B, Hughes JD

Drug Design, Development and Therapy 2016, 10:1029-1034

Published Date: 7 March 2016

Original Research

Amsacrine analog-loaded solid lipid nanoparticle to resolve insolubility for injection delivery: characterization and pharmacokinetics

Fang YP, Chuang CH, Wu PC, Huang YB, Tzeng CC, Chen YL, Liu YT, Tsai YH, Tsai MJ

Drug Design, Development and Therapy 2016, 10:1019-1028

Published Date: 4 March 2016

Original Research

Plasmodium-infected erythrocytes (pRBC) induce endothelial cell apoptosis via a heme-mediated signaling pathway

Liu M, Dickinson-Copeland C, Hassana S, Stiles JK

Drug Design, Development and Therapy 2016, 10:1009-1018

Published Date: 3 March 2016

Original Research

A 5-fluorouracil-loaded floating gastroretentive hollow microsphere: development, pharmacokinetic in rabbits, and biodistribution in tumor-bearing mice

Huang Y, Wei YM, Yang HR, Pi C, Liu H, Ye Y, Zhao L

Drug Design, Development and Therapy 2016, 10:997-1008

Published Date: 3 March 2016

Original Research

Da0324, an inhibitor of nuclear factor-κB activation, demonstrates selective antitumor activity on human gastric cancer cells

Jin R, Xia Y, Chen Q, Li W, Chen D, Ye H, Zhao C, Du X, Shi D, Wu J, Liang G

Drug Design, Development and Therapy 2016, 10:979-995

Published Date: 2 March 2016

Original Research

Eucommia bark (Du-Zhong) improves diabetic nephropathy without altering blood glucose in type 1-like diabetic rats

Niu HS, Liu IM, Niu CS, Ku PM, Hsu CT, Cheng JT

Drug Design, Development and Therapy 2016, 10:971-978

Published Date: 2 March 2016

Original Research

Solubility enhancement of simvastatin by arginine: thermodynamics, solute–solvent interactions, and spectral analysis

Meor Mohd Affandi MMR, Tripathy M, Shah SAA, Majeed ABA

Drug Design, Development and Therapy 2016, 10:959-969

Published Date: 2 March 2016

Original Research

Effects of Dang-Gui-Bu-Xue-Tang, an herbal decoction, on iron uptake in iron-deficient anemia

Huang GC, Chen SY, Tsai PW, Ganzon JG, Lee CJ, Shiah HS, Wang CC

Drug Design, Development and Therapy 2016, 10:949-957

Published Date: 2 March 2016

Original Research

Celastrol inhibits prostaglandin E2-induced proliferation and osteogenic differentiation of fibroblasts isolated from ankylosing spondylitis hip tissues in vitro

Zou YC, Yang XW, Yuan SG, Zhang P, Li YK

Drug Design, Development and Therapy 2016, 10:933-948

Published Date: 7 March 2016

Original Research

Effect of picroside II on erythrocyte deformability and lipid peroxidation in rats subjected to hind limb ischemia reperfusion injury

Çomu FM, Kılıç Y, Özer A, Kirişçi M, Dursun AD, Tatar T, Zor MH, Kartal H, Küçük A, Boyunağa H, Arslan M

Drug Design, Development and Therapy 2016, 10:927-931

Published Date: 1 March 2016

Original Research

Naringenin-loaded solid lipid nanoparticles: preparation, controlled delivery, cellular uptake, and pulmonary pharmacokinetics

Ji P, Yu T, Liu Y, Jiang J, Xu J, Zhao Y, Hao Y, Qiu Y, Zhao W, Wu C

Drug Design, Development and Therapy 2016, 10:911-925

Published Date: 1 March 2016

Original Research

Cost-effectiveness comparison of lamivudine plus adefovir combination treatment and nucleos(t)ide analog monotherapies in Chinese chronic hepatitis B patients

Zhang C, Ke WX, Liu L, Gao YH, Yao ZJ, Ye XH, Zhou SD, Yang Y

Drug Design, Development and Therapy 2016, 10:897-910

Published Date: 1 March 2016

Original Research

The aqueous extract of Glycyrrhiza inflata can upregulate unfolded protein response-mediated chaperones to reduce tau misfolding in cell models of Alzheimer’s disease

Chang KH, Chen IC, Lin HY, Chen HC, Lin CH, Lin TH, Weng YT, Chao CY, Wu YR, Lin JY, Lee-Chen GJ, Chen CM

Drug Design, Development and Therapy 2016, 10:885-896

Published Date: 29 February 2016

Review

Spotlight on lenvatinib in the treatment of thyroid cancer: patient selection and perspectives

Costa R, Carneiro BA, Chandra S, Pai SG, Chae YK, Kaplan JB, Garrett HB, Agulnik M, Kopp PA, Giles FJ

Drug Design, Development and Therapy 2016, 10:873-884

Published Date: 29 February 2016

Review

The interplay of post-translational modification and gene therapy

Osamor VC, Chinedu SN, Azuh DE, Iweala EJ, Ogunlana OO

Drug Design, Development and Therapy 2016, 10:861-871

Published Date: 29 February 2016

Original Research

Papaverine inhibits lipopolysaccharide-induced microglial activation by suppressing NF-κB signaling pathway

Dang Y, Mu Y, Wang K, Xu K, Yang J, Zhu Y, Luo B

Drug Design, Development and Therapy 2016, 10:851-859

Published Date: 26 February 2016

Original Research

The mechanism underlying alpinetin-mediated alleviation of pancreatitis-associated lung injury through upregulating aquaporin-1

Liang XS, Zhang B, Chen Q, Zhang J, Lei B, Li B, Wei YC, Zhai R, Liang ZQ, He SQ, Tang B

Drug Design, Development and Therapy 2016, 10:841-850

Published Date: 24 February 2016

Original Research

Maximizing the encapsulation efficiency and the bioavailability of controlled-release cetirizine microspheres using Draper–Lin small composite design

El-Say KM

Drug Design, Development and Therapy 2016, 10:825-839

Published Date: 24 February 2016

Original Research

Comprehensive evaluation of formulation factors for ocular penetration of fluoroquinolones in rabbits using cassette dosing technique

Sharma C, Biswas NR, Ojha S, Velpandian T

Drug Design, Development and Therapy 2016, 10:811-823

Published Date: 22 February 2016

Original Research

Total saponin of Dioscoreae hypoglaucae rhizoma ameliorates streptozotocin-induced diabetic nephropathy

Guo C, Ding G, Huang W, Wang Z, Meng Z, Xiao W

Drug Design, Development and Therapy 2016, 10:799-810

Published Date: 24 February 2016

Original Research

Effects of Xuanbai Chengqi decoction on lung compliance for patients with exogenous pulmonary acute respiratory distress syndrome

Mao ZR, Wang HF

Drug Design, Development and Therapy 2016, 10:793-798

Published Date: 19 February 2016

Original Research

Andrographolide suppresses thymic stromal lymphopoietin in phorbol myristate acetate/calcium ionophore A23187-activated mast cells and 2,4-dinitrofluorobenzene-induced atopic dermatitis-like mice model

Li CX, Li HG, Zhang H, Cheng RH, Li M, Liang JY, Gu Y, Ling B, Yao ZR, Yu H

Drug Design, Development and Therapy 2016, 10:781-791

Published Date: 19 February 2016

Original Research

Calycosin inhibits migration and invasion through modulation of transforming growth factor beta-mediated mesenchymal properties in U87 and U251 cells

Nie XH, Ou-yang J, Xing Y, Li DY, Liu RE, Xu RX

Drug Design, Development and Therapy 2016, 10:767-779

Published Date: 22 February 2016

Review

Potential for bispecific T-cell engagers: role of blinatumomab in acute lymphoblastic leukemia

Le Jeune C, Thomas X

Drug Design, Development and Therapy 2016, 10:757-765

Published Date: 18 February 2016

Original Research

Synergistic roles of p53 and HIF1α in human renal cell carcinoma-cell apoptosis responding to the inhibition of mTOR and MDM2 signaling pathways

Liu QJ, Shen HL, Lin J, Xu XH, Ji ZG, Han X, Shang DH, Yang PQ

Drug Design, Development and Therapy 2016, 10:745-755

Published Date: 18 February 2016

Original Research

A network pharmacology approach to discover active compounds and action mechanisms of San-Cao Granule for treatment of liver fibrosis

Wei S, Niu M, Wang J, Wang J, Su H, Luo S, Zhang X, Guo Y, Liu L, Liu F, Zhao Q, Chen H, Xiao X, Zhao P, Zhao Y

Drug Design, Development and Therapy 2016, 10:733-743

Published Date: 19 February 2016

Original Research

Treatment with a Ginkgo biloba extract, EGb 761, inhibits excitotoxicity in an animal model of spinocerebellar ataxia type 17

Huang DS, Lin HY, Lee-Chen GJ, Hsieh-Li HM, Wu CH, Lin JY

Drug Design, Development and Therapy 2016, 10:723-731

Published Date: 18 February 2016

Original Research

5-(Bis(3-(2-hydroxyethyl)-1H-indol-2-yl)methyl)-2-hydroxybenzoic acid (BHIMHA): showing a strategy of designing drug to block lung metastasis of tumors

Gan T, Wang Y, Zhao M, Wu J, Yang J, Peng S

Drug Design, Development and Therapy 2016, 10:711-721

Published Date: 16 February 2016

Original Research

The clinicopathological significance and ethnic difference of FHIT hypermethylation in non-small-cell lung carcinoma: a meta-analysis and literature review

Wu X, Wu G, Yao X, Hou G, Jiang F

Drug Design, Development and Therapy 2016, 10:699-709

Published Date: 15 February 2016

Corrigendum

Treatment of osteoporosis with eldecalcitol, a new vitamin D analog: a comprehensive review and meta-analysis of randomized clinical trials [Corrigendum]

Xu Z, Fan C, Zhao X, Tao H

Drug Design, Development and Therapy 2016, 10:697-698

Published Date: 16 February 2016

Original Research

Effects of 22 novel CYP2D6 variants found in Chinese population on the metabolism of dapoxetine

Xu RA, Gu EM, Zhou Q, Yuan LJ, Hu XX, Cai JP, Hu GX

Drug Design, Development and Therapy 2016, 10:687-696

Published Date: 15 February 2016

Original Research

Long-term use of amiodarone before heart transplantation significantly reduces early post-transplant atrial fibrillation and is not associated with increased mortality after heart transplantation

Rivinius R, Helmschrott M, Ruhparwar A, Schmack B, Erbel C, Gleissner CA, Akhavanpoor M, Frankenstein L, Darche FF, Schweizer PA, Thomas D, Ehlermann P, Bruckner T, Katus HA, Doesch AO

Drug Design, Development and Therapy 2016, 10:677-686

Published Date: 16 February 2016

Review

Drug-loaded erythrocytes: on the road toward marketing approval

Bourgeaux V, Lanao JM, Bax BE, Godfrin Y

Drug Design, Development and Therapy 2016, 10:665-676

Published Date: 11 February 2016

Original Research

Therapeutic effects of tyroservatide on metastasis of lung cancer and its mechanism affecting integrin–focal adhesion kinase signal transduction

Huang YT, Zhao L, Fu Z, Zhao M, Song XM, Jia J, Wang S, Li JP, Zhu ZF, Lin G, Lu R, Yao Z

Drug Design, Development and Therapy 2016, 10:649-663

Published Date: 3 March 2016

Original Research

Epigallocatechin-3-gallate attenuates apoptosis and autophagy in concanavalin A-induced hepatitis by inhibiting BNIP3

Li S, Xia Y, Chen K, Li J, Liu T, Wang F, Lu J, Zhou Y, Guo C

Drug Design, Development and Therapy 2016, 10:631-647

Published Date: 15 February 2016

Original Research

Protective effect of fucoidan from Fucus vesiculosus on liver fibrosis via the TGF-β1/Smad pathway-mediated inhibition of extracellular matrix and autophagy

Li J, Chen K, Li S, Feng J, Liu T, Wang F, Zhang R, Xu S, Zhou Y, Zhou S, Xia Y, Lu J, Zhou Y, Guo C

Drug Design, Development and Therapy 2016, 10:619-630

Published Date: 12 February 2016

Review

Adjuvant therapies for Parkinson’s disease: critical evaluation of safinamide

Stocchi F, Torti M

Drug Design, Development and Therapy 2016, 10:609-618

Published Date: 5 February 2016

Original Research

Randomized clinical trial: pharmacokinetics and safety of multimatrix mesalamine for treatment of pediatric ulcerative colitis

Cuffari C, Pierce D, Korczowski B, Fyderek K, Van Heusen H, Hossack S, Wan H, Edwards AY, Martin P

Drug Design, Development and Therapy 2016, 10:593-607

Published Date: 4 February 2016

Original Research

Establishment of a novel therapeutic vector targeting the trigeminal ganglion in rats

Xu K, Pan SY, Song JX, ,Liu XN, An N, Zheng X

Drug Design, Development and Therapy 2016, 10:585-592

Published Date: 4 February 2016

Original Research

miR-125b acts as a tumor suppressor in chondrosarcoma cells by the sensitization to doxorubicin through direct targeting the ErbB2-regulated glucose metabolism

Tang XY, Zheng W, Ding M, Guo KJ, Yuan F, Feng H, Deng B, Sun W, Hou Y, Gao L

Drug Design, Development and Therapy 2016, 10:571-583

Published Date: 24 February 2016

Original Research

Curcumin enhances the cytogenotoxic effect of etoposide in leukemia cells through induction of reactive oxygen species

Papież MA, Krzyściak W, Szade K, Bukowska-Straková K, Kozakowska M, Hajduk K, Bystrowska B, Dulak J, Jozkowicz A

Drug Design, Development and Therapy 2016, 10:557-570

Published Date: 4 February 2016

Original Research

Targeting the D1-N-methyl-D-aspartate receptor complex reduces L-dopa-induced dyskinesia in 6-hydroxydopamine-lesioned Parkinson’s rats

Song L, Zhang ZZ, Hu RG, Cheng J, Li L, Fan QY, Wu N, Gan J, Zhou MZ, Liu ZG

Drug Design, Development and Therapy 2016, 10:547-555

Published Date: 3 February 2016

Hypothesis

Antiviral therapy: a perspective

Shahidi Bonjar AH

Drug Design, Development and Therapy 2016, 10:541-546

Published Date: 2 February 2016

Review

Profile of tofacitinib citrate and its potential in the treatment of moderate-to-severe chronic plaque psoriasis

Di Lernia V, Bardazzi F

Drug Design, Development and Therapy 2016, 10:533-539

Published Date: 29 January 2016

Original Research

Preparation and characterization of silymarin synchronized-release microporous osmotic pump tablets

Zeng QP, Liu ZH, Huang AW, Zhang J, Song HT

Drug Design, Development and Therapy 2016, 10:519-531

Published Date: 29 January 2016

Review

Treatment of osteoporosis with eldecalcitol, a new vitamin D analog: a comprehensive review and meta-analysis of randomized clinical trials

Xu Z, Fan C, Zhao X, Tao H

Drug Design, Development and Therapy 2016, 10:509-517

Published Date: 28 January 2016

Review

Preparation, characterization, and potential application of chitosan, chitosan derivatives, and chitosan metal nanoparticles in pharmaceutical drug delivery

Ahmed TA, Aljaeid BM

Drug Design, Development and Therapy 2016, 10:483-507

Published Date: 28 January 2016

Review

Efficacy and safety of iron-chelation therapy with deferoxamine, deferiprone, and deferasirox for the treatment of iron-loaded patients with non-transfusion-dependent thalassemia syndromes

Kontoghiorghe CN, Kontoghiorghes GJ

Drug Design, Development and Therapy 2016, 10:465-481

Published Date: 29 January 2016

Original Research

Determination of the binding mode for anti-inflammatory natural product xanthohumol with myeloid differentiation protein 2

Fu W, Chen L, Wang Z, Zhao C, Chen G, Liu X, Dai Y, Cai Y, Li C, Zhou J, Liang G

Drug Design, Development and Therapy 2016, 10:455-463

Published Date: 27 January 2016

Original Research

Amelioration of concanavalin A-induced autoimmune hepatitis by magnesium isoglycyrrhizinate through inhibition of CD4+CD25-CD69+ subset proliferation

Yang Q, Wang J, Liu R, Wang Z, Li Y, Zhang Y, Hao X, Huang Y, Xie W, Wei H

Drug Design, Development and Therapy 2016, 10:443-453

Published Date: 25 January 2016

Corrigendum

Efficacy of trabectedin in advanced soft tissue sarcoma: beyond lipo- and leiomyosarcoma [Corrigendum]

De Sanctis R, Marrari A, Marchetti S, Mussi C, Balzarini L, Lutman FR, Daolio P, Bastoni S, Bertuzzi AF, Quagliuolo V, Santoro A

Drug Design, Development and Therapy 2016, 10:441-442

Published Date: 28 January 2016

Original Research

In vitro stress effect on degradation and drug release behaviors of basic fibroblast growth factor – poly(lactic-co-glycolic-acid) microsphere

Xiong Y, Yu ZP, Lang Y, Hu JY, Li H, Yan YG, Tu CQ, Yang TF, Song YM, Duan H, Pei FX

Drug Design, Development and Therapy 2016, 10:431-440

Published Date: 25 January 2016

Original Research

Formulation, optimization, and pharmacodynamic evaluation of chitosan/phospholipid/β-cyclodextrin microspheres

Shan L, Tao EX, Meng QH, Hou WX, Liu K, Shang HC, Tang JB, Zhang WF

Drug Design, Development and Therapy 2016, 10:417-429

Published Date: 25 January 2016

Original Research

Depot injectable atorvastatin biodegradable in situ gel: development, optimization, in vitro, and in vivo evaluation

Ahmed TA, Alharby YA, El-Helw AM, Hosny KM, El-Say KM

Drug Design, Development and Therapy 2016, 10:405-415

Published Date: 20 January 2016

Original Research

Saussurea tridactyla Sch. Bip.-derived polysaccharides and flavones reduce oxidative damage in ultraviolet B-irradiated HaCaT cells via a p38MAPK-independent mechanism

Guo Y, Sun J, Ye J, Ma W, Yan HL, Wang G

Drug Design, Development and Therapy 2016, 10:389-403

Published Date: 20 January 2016

Case report

High-dose OxyContin to treat pain associated with bone metastasis in patients with small-cell lung cancer: a case study report

Zhou T, Zhang X, Dong Y, Zhuang FF, Jiang FQ, Yu JM, Zhang B

Drug Design, Development and Therapy 2016, 10:383-387

Published Date: 19 January 2016

Original Research

The improvement effects of edible bird’s nest on proliferation and activation of B lymphocyte and its antagonistic effects on immunosuppression induced by cyclophosphamide

Zhao R, Li G, Kong XJ, Huang XY, Li W, Zeng YY, Lai XP

Drug Design, Development and Therapy 2016, 10:371-381

Published Date: 21 January 2016

Original Research

Effects of probenecid and cimetidine on the pharmacokinetics of nemonoxacin in healthy Chinese volunteers

Zhang YF, Dai XJ, Yang Y, Chen XY, Wang T, Tang YB, Tsai CY, Chang LW, Chang YT, Zhong DF

Drug Design, Development and Therapy 2016, 10:357-370

Published Date: 20 January 2016

Letter

Short-term maraviroc exposure, a clinical approach to decide on maraviroc prescription in HIV-1-infected treatment-naïve patients

Gonzalez-Serna A, Genebat M, Ruiz-Mateos E, Leal M

Drug Design, Development and Therapy 2016, 10:353-356

Published Date: 18 January 2016

Original Research

Dose comparison of conivaptan (Vaprisol®) in patients with euvolemic or hypervolemic hyponatremia – efficacy, safety, and pharmacokinetics

Palmer BF, Rock AD, Woodward EJ

Drug Design, Development and Therapy 2016, 10:339-351

Published Date: 18 January 2016

Original Research

Clinical pharmacology study of cariprazine (MP-214) in patients with schizophrenia (12-week treatment)

Nakamura T, Kubota T, Iwakaji A, Imada M, Kapás M, Morio Y

Drug Design, Development and Therapy 2016, 10:327-338

Published Date: 14 January 2016

Original Research

YiQiFuMai powder injection ameliorates blood–brain barrier dysfunction and brain edema after focal cerebral ischemia–reperfusion injury in mice

Cao GS, Ye XY, Xu YQ, Yin MZ, Chen HL, Kou JP, Yu BY

Drug Design, Development and Therapy 2016, 10:315-325

Published Date: 14 January 2016

Original Research

Evidence of the gastroprotective and anti-Helicobacter pylori activities of β-mangostin isolated from Cratoxylum arborescens (vahl) blume

Sidahmed HMA, Hashim NM, Mohan S, Abdelwahab SI, Taha MME, Dehghan F, Yahayu M, Ee GCL, Loke MF, Vadivelu J

Drug Design, Development and Therapy 2016, 10:297-313

Published Date: 13 January 2016

Original Research

Liposomal flucytosine capped with gold nanoparticle formulations for improved ocular delivery

Salem HF, Ahmed SM, Omar MM

Drug Design, Development and Therapy 2016, 10:277-295

Published Date: 13 January 2016

Original Research

Quetiapine monotherapy in acute treatment of generalized anxiety disorder: a systematic review and meta-analysis of randomized controlled trials

Maneeton N, Maneeton B, Woottiluk P, Likhitsathian S, Suttajit S, Boonyanaruthee V, Srisurapanont M

Drug Design, Development and Therapy 2016, 10:259-276

Published Date: 12 January 2016

Original Research

A clinical prognostic scoring system for resectable gastric cancer to predict survival and benefit from paclitaxel- or oxaliplatin-based adjuvant chemotherapy

Qian J, Qian Y, Wang J, Gu B, Pei D, He S, Zhu F, Røe OD, Xu J, Liu L, Gu Y, Guo R, Yin Y, Shu Y, Chen X

Drug Design, Development and Therapy 2016, 10:241-258

Published Date: 24 February 2016

Review

Pasireotide: a novel treatment for patients with acromegaly

Cuevas-Ramos D, Fleseriu M

Drug Design, Development and Therapy 2016, 10:227-239

Published Date: 11 January 2016

Review

Spotlight on ixazomib: potential in the treatment of multiple myeloma

Muz B, Ghazarian RN, Ou M, Luderer MJ, Kusdono HD, Azab AK

Drug Design, Development and Therapy 2016, 10:217-226

Published Date: 11 January 2016

Original Research

Preparation, characterization, and in vivo evaluation of intranasally administered liposomal formulation of donepezil

Al Asmari AK, Ullah Z, Tariq M, Fatani A

Drug Design, Development and Therapy 2016, 10:205-215

Published Date: 12 January 2016

Original Research

Baicalein attenuates the quorum sensing-controlled virulence factors of Pseudomonas aeruginosa and relieves the inflammatory response in P. aeruginosa-infected macrophages by downregulating the MAPK and NFκB signal-transduction pathways

Luo J, Kong JL, Dong BY, Huang H, Wang K, Wu LH, Hou CC, Liang Y, Li B, Chen YQ

Drug Design, Development and Therapy 2016, 10:183-203

Published Date: 7 January 2016

Original Research

Design and evaluation of novel interferon lambda analogs with enhanced antiviral activity and improved drug attributes

Yu D, Zhao M, Dong L, Zhao L, Zou M, Sun H, Zhang M, Liu H, Zou Z

Drug Design, Development and Therapy 2016, 10:163-182

Published Date: 6 January 2016

Original Research

Isolation and evaluation of biological efficacy of quercetol in human hepatic carcinoma cells

Ali H, Dixit S, Ali D, Alkahtane AA, Alarifi S, Ali BA, Alkahtani S

Drug Design, Development and Therapy 2016, 10:155-162

Published Date: 6 January 2016

Original Research

Discovery of a novel anticancer agent with both anti-topoisomerase I and II activities in hepatocellular carcinoma SK-Hep-1 cells in vitro and in vivo: Cinnamomum verum component 2-methoxycinnamaldehyde

Perng DS, Tsai YH, Cherng J, Wang JS, Chou KS, Shih CW, Cherng JM

Drug Design, Development and Therapy 2016, 10:141-153

Published Date: 5 January 2016

Original Research

Design, synthesis, and antihypertensive activity of curcumin-inspired compounds via ACE inhibition and vasodilation, along with a bioavailability study for possible benefit in cardiovascular diseases

Zhuang XD, Liao LZ, Dong XB, Hu X, Guo Y, Du ZM, Liao XX, Wang LC

Drug Design, Development and Therapy 2016, 10:129-139

Published Date: 5 January 2016

Original Research

Self-emulsifying drug delivery systems as a tool to improve solubility and bioavailability of resveratrol

Balata GF, Essa EA, Shamardl HA, Zaidan SH, Abourehab MAS

Drug Design, Development and Therapy 2016, 10:117-128

Published Date: 5 January 2016

Original Research

Efficacy and safety of topical herbal medicine treatment on recurrent aphthous stomatitis: a systemic review

Li CL, Huang HL, Wang WC, Hua H

Drug Design, Development and Therapy 2016, 10:107-115

Published Date: 31 December 2015

Original Research

The gastroprotective effects of hydroalcoholic extract of Monolluma quadrangula against ethanol-induced gastric mucosal injuries in Sprague Dawley rats

Ibrahim IAA, Abdulla MA, Hajrezaie M, Bader A, Shahzad N, Al-Ghamdi SS, Gushash AS, Hasanpourghadi M

Drug Design, Development and Therapy 2016, 10:93-105

Published Date: 30 December 2015

Original Research

Promoting effect of small molecules in cardiomyogenic and neurogenic differentiation of rat bone marrow-derived mesenchymal stem cells

Khanabdali R, Saadat A, Fazilah M, Bazli KFK, Qazi RM, Khalid RS, Hasan Adli DS, Moghadamtousi SZ, Naeem N, Khan I, Salim A, Shamsuddin SAA, Mohan G

Drug Design, Development and Therapy 2016, 10:81-91

Published Date: 24 December 2015

Original Research

MicroRNA-125a-5p modulates human cervical carcinoma proliferation and migration by targeting ABL2

Qin X, Wan Y, Wang S, Xue M

Drug Design, Development and Therapy 2016, 10:71-79

Published Date: 24 December 2015

Original Research

BCc1, the novel antineoplastic nanocomplex, showed potent anticancer effects in vitro and in vivo

Kalanaky S, Hafizi M, Fakharzadeh S, Vasei M, Langroudi L, Janzamin E, Hashemi SM, Khayamzadeh M, Soleimani M, Akbari ME, Nazaran MH

Drug Design, Development and Therapy 2016, 10:59-70

Published Date: 30 December 2015

Original Research

Effect of milrinone on cardiac functions in patients undergoing coronary artery bypass graft: a meta-analysis of randomized clinical trials

You Z, Huang L, Cheng X, Wu Q, Jiang X, Wu Y

Drug Design, Development and Therapy 2016, 10:53-58

Published Date: 24 December 2015

Review

MEK inhibitors and their potential in the treatment of advanced melanoma: the advantages of combination therapy

Tran KA, Cheng MY, Mitra A, Ogawa H, Shi VY, Olney LP, Kloxin AM, Maverakis E

Drug Design, Development and Therapy 2016, 10:43-52

Published Date: 21 December 2015

Review

Modulation of neurotrophic signaling pathways by polyphenols

Moosavi F, Hosseini R, Saso L, Firuzi O

Drug Design, Development and Therapy 2016, 10:23-42

Published Date: 21 December 2015

Original Research

Comparative pharmacokinetics and pharmacodynamics of a PEGylated recombinant human growth hormone and daily recombinant human growth hormone in growth hormone-deficient children

Hou L, Chen ZH, Liu D, Cheng YG, Luo XP

Drug Design, Development and Therapy 2016, 10:13-21

Published Date: 18 December 2015

Original Research

Plasmid pORF-hTRAIL targeting to glioma using transferrin-modified polyamidoamine dendrimer

Gao S, Li J, Jiang C, Hong B, Hao B

Drug Design, Development and Therapy 2016, 10:1-11

Published Date: 17 December 2015