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Drug Design, Development and Therapy


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Failure mode and effects analysis drastically reduced potential risks in clinical trial conduct

Lee H, Lee H, Baik J, Kim HJ, Kim R

Drug Design, Development and Therapy 2017, 11:3035-3043

Published Date: 19 October 2017

Edaravone inhibits pressure overload-induced cardiac fibrosis and dysfunction by reducing expression of angiotensin II AT1 receptor

Zhang WW, Bai F, Wang J, Zheng RH, Yang LW, James EA, Zhao ZQ

Drug Design, Development and Therapy 2017, 11:3019-3033

Published Date: 16 October 2017

Amelioration of collagen-induced arthritis using antigen-loaded dendritic cells modified with NF-κB decoy oligodeoxynucleotides

Jiang HM, Hu HG, Zhang YL, Yue P, Ning LC, Zhou Y, Shi P, Yuan R

Drug Design, Development and Therapy 2017, 11:2997-3007

Published Date: 13 October 2017

5H-benzo[h]thiazolo[2,3-b]quinazolines ameliorate NDEA-induced hepatocellular carcinogenesis in rats through IL-6 downregulation along with oxidative and metabolic stress reduction

Keshari AK, Singh AK, Kumar U, Raj V, Rai A, Kumar P, Kumar D, Maity B, Nath S, Prakash A, Saha S

Drug Design, Development and Therapy 2017, 11:2981-2995

Published Date: 13 October 2017

Protective effect of DA-9401 in finasteride-induced apoptosis in rat testis: inositol requiring kinase 1 and c-Jun N-terminal kinase pathway

Soni KK, Shin YS, Choi BR, Karna KK, Kim HK, Lee SW, Kim CY, Park JK

Drug Design, Development and Therapy 2017, 11:2969-2979

Published Date: 11 October 2017

Halofuginone ameliorates inflammation in severe acute hepatitis B virus (HBV)-infected SD rats through AMPK activation

Zhan WL, Kang YH, Chen N, Mao CS, Kang Y, Shang J

Drug Design, Development and Therapy 2017, 11:2947-2955

Published Date: 10 October 2017

Short vs prolonged dual antiplatelet treatment upon endovascular stenting of peripheral arteries

Kronlage M, Wassmann M, Vogel B, Müller OJ, Blessing E, Katus H, Erbel C

Drug Design, Development and Therapy 2017, 11:2937-2945

Published Date: 6 October 2017

Spotlight on ertugliflozin and its potential in the treatment of type 2 diabetes: evidence to date

Cinti F, Moffa S, Impronta F, Cefalo CMA, Sun VA, Sorice GP, Mezza T, Giaccari A

Drug Design, Development and Therapy 2017, 11:2905-2919

Published Date: 3 October 2017

Current perspective on rituximab in rheumatic diseases

Schioppo T, Ingegnoli F

Drug Design, Development and Therapy 2017, 11:2891-2904

Published Date: 3 October 2017

The new era of nanotechnology, an alternative to change cancer treatment

Jurj A, Braicu C, Pop LA, Tomuleasa C, Gherman CD, Berindan-Neagoe I

Drug Design, Development and Therapy 2017, 11:2871-2890

Published Date: 27 September 2017

Downregulation of A20 increases the cytotoxicity of IFN-γ in hepatocellular carcinoma cells

Yin L, Fang Z, Shen N, Qiu Y, Li A, Zhang Y

Drug Design, Development and Therapy 2017, 11:2841-2850

Published Date: 26 September 2017

Eluxadoline in the treatment of diarrhea-predominant irritable bowel syndrome

Özdener AE, Rivkin A

Drug Design, Development and Therapy 2017, 11:2827-2840

Published Date: 26 September 2017

Axitinib in the treatment of renal cell carcinoma: design, development, and place in therapy

Bellesoeur A, Carton E, Alexandre J, Goldwasser F, Huillard O

Drug Design, Development and Therapy 2017, 11:2801-2811

Published Date: 21 September 2017

Dexmedetomidine reduces the neuronal apoptosis related to cardiopulmonary bypass by inhibiting activation of the JAK2–STAT3 pathway

Chen Y, Zhang X, Zhang B, He G, Zhou L, Xie Y

Drug Design, Development and Therapy 2017, 11:2787-2799

Published Date: 26 September 2017

Biodegradable rifampicin-releasing coating of surgical meshes for the prevention of bacterial infections

Reinbold J, Hierlemann T, Urich L, Uhde AK, Müller I, Weindl T, Vogel U, Schlensak C, Wendel HP, Krajewski S

Drug Design, Development and Therapy 2017, 11:2753-2762

Published Date: 18 September 2017

The roles of epigallocatechin-3-gallate in the treatment of neuropathic pain: an update on preclinical in vivo studies and future perspectives

Bimonte S, Cascella M, Schiavone V, Mehrabi-Kermani F, Cuomo A

Drug Design, Development and Therapy 2017, 11:2737-2742

Published Date: 13 September 2017

Pharmacokinetic and safety evaluation of MB12066, an NQO1 substrate

Lee HW, Seong SJ, Ohk B, Kang WY, Gwon MR, Kim BK, Kim HJ, Yoon YR

Drug Design, Development and Therapy 2017, 11:2719-2725

Published Date: 13 September 2017

Localized neuropathic pain: an expert consensus on local treatments

Pickering G, Martin E, Tiberghien F, Delorme C, Mick G

Drug Design, Development and Therapy 2017, 11:2709-2718

Published Date: 13 September 2017

Metal organic frameworks as a drug delivery system for flurbiprofen

AL Haydar M, Abid HR, Sunderland B, Wang S

Drug Design, Development and Therapy 2017, 11:2685-2695

Published Date: 11 September 2017

Cissus quadrangularis inhibits IL-1β induced inflammatory responses on chondrocytes and alleviates bone deterioration in osteotomized rats via p38 MAPK signaling [Corrigendum]

Kanwar JR, Samarasinghe RM, Kumar K, Arya R, Sanjeev S, Zhou SF, Sasidharan S, Kanwar RK

Drug Design, Development and Therapy 2017, 11:2683-2684

Published Date: 12 September 2017

Extended infusion versus intermittent infusion of imipenem in the treatment of ventilator-associated pneumonia

Ibrahim MM, Tammam TF, Ebaed MED, Sarhan HA, Gad GF, Hussein AK

Drug Design, Development and Therapy 2017, 11:2677-2682

Published Date: 6 September 2017

Palatability and physical properties of potassium-binding resin RDX7675: comparison with sodium polystyrene sulfonate

Zann V, McDermott J, Jacobs JW, Davidson JP, Lin F, Korner P, Blanks RC, Rosenbaum DP

Drug Design, Development and Therapy 2017, 11:2663-2673

Published Date: 6 September 2017

In vitro inhibitory activities of magnolol against Candida spp.

Zhou PR, Fu JY, Hua H, Liu XS

Drug Design, Development and Therapy 2017, 11:2653-2661

Published Date: 6 September 2017

Radium 223 dichloride for prostate cancer treatment

Deshayes E, Roumiguie M, Thibault C, Beuzeboc P, Cachin F, Hennequin C, Huglo D, Rozet F, Kassab-Chahmi D, Rebillard X, Houédé N

Drug Design, Development and Therapy 2017, 11:2643-2651

Published Date: 6 September 2017

Recent developments in the clinical pharmacology of rolapitant: subanalyses in specific populations

Rapoport BL, Aapro M, Chasen MR, Jordan K, Navari RM, Schnadig I, Schwartzberg L

Drug Design, Development and Therapy 2017, 11:2621-2629

Published Date: 5 September 2017

Protective role of quercetin against manganese-induced injury in the liver, kidney, and lung; and hematological parameters in acute and subchronic rat models

Bahar E, Lee GH, Bhattarai KR, Lee HY, Kim HK, Handigund M, Choi MK, Han SY, Chae HJ, Yoon H

Drug Design, Development and Therapy 2017, 11:2605-2619

Published Date: 5 September 2017

Puerarin transport across rat nasal epithelial cells and the influence of compatibility with paeoniflorin and menthol

Zhang L, Du S, Lu Y, Liu C, Wu H, Tian Z, Wang M, Yang C

Drug Design, Development and Therapy 2017, 11:2581-2593

Published Date: 1 September 2017

Quantum mechanics implementation in drug-design workflows: does it really help?

Arodola OA, Soliman MES

Drug Design, Development and Therapy 2017, 11:2551-2564

Published Date: 31 August 2017

New insight into the pathogenesis of nail psoriasis and overview of treatment strategies

Ventura A, Mazzeo M, Gaziano R, Galluzzo M, Bianchi L, Campione E

Drug Design, Development and Therapy 2017, 11:2527-2535

Published Date: 30 August 2017

Secondary prevention of major cerebrovascular events with seven different statins: a multi-treatment meta-analysis

Zhong P, Wu D, Ye X, Wu Y, Li T, Tong S, Liu X

Drug Design, Development and Therapy 2017, 11:2517-2526

Published Date: 30 August 2017

Therapy with pamidronate in children with osteogenesis imperfecta

Marginean O, Tamasanu RC, Mang N, Mozos I, Brad GF

Drug Design, Development and Therapy 2017, 11:2507-2515

Published Date: 28 August 2017

Advances in the delivery of buprenorphine for opioid dependence

Rosenthal RN, Goradia VV

Drug Design, Development and Therapy 2017, 11:2493-2505

Published Date: 28 August 2017

Paeoniflorin suppresses pancreatic cancer cell growth by upregulating HTRA3 expression

Li YJ, Gong LL, Qi RL, Sun Q, Xia XX, He HH, Ren JS, Zhu ON, Zhuo DB

Drug Design, Development and Therapy 2017, 11:2481-2491

Published Date: 23 August 2017

Preliminary study of nanonized lamotrigine containing products for nasal powder formulation

Gieszinger P, Csóka I, Pallagi E, Katona G, Jójárt-Laczkovich O, Szabó-Révész P, Ambrus R

Drug Design, Development and Therapy 2017, 11:2453-2466

Published Date: 23 August 2017

Aceclofenac nanocrystals with enhanced in vitro, in vivo performance: formulation optimization, characterization, analgesic and acute toxicity studies

Rahim H, Sadiq A, Khan S, Khan MA, Shah SMH, Hussain Z, Ullah R, Shahat AA, Ibrahim K

Drug Design, Development and Therapy 2017, 11:2443-2452

Published Date: 23 August 2017

Sensitization of gastric cancer cells to alkylating agents by glaucocalyxin B via cell cycle arrest and enhanced cell death

Ur Rahman MS, Zhang L, Wu LY, Xie YQ, Li CC, Cao J

Drug Design, Development and Therapy 2017, 11:2431-2441

Published Date: 22 August 2017

Metformin: a review of its potential indications

Wang YW, He SJ, Feng X, Cheng J, Luo YT, Tian L, Huang Q

Drug Design, Development and Therapy 2017, 11:2421-2429

Published Date: 22 August 2017

Pomalidomide in the treatment of multiple myeloma: design, development and place in therapy

Rios-Tamayo R, Martín-García A, Alarcón-Payer C, Sánchez-Rodríguez D, Guardia AM, García Collado CG, Jiménez Morales A, Jurado Chacón M, Cabeza Barrera J

Drug Design, Development and Therapy 2017, 11:2399-2408

Published Date: 22 August 2017

Onychomadesis associated with chemotherapy: case report and mini literature review

Li A, Li Y, Ge L, Li P, Li W

Drug Design, Development and Therapy 2017, 11:2373-2376

Published Date: 14 August 2017

Widening use of dexamethasone implant for the treatment of macular edema

Bonfiglio V, Reibaldi M, Fallico M, Russo A, Pizzo A, Fichera S, Rapisarda C, Macchi I, Avitabile T, Longo A

Drug Design, Development and Therapy 2017, 11:2359-2372

Published Date: 16 August 2017

Microbial challenge test of a novel epoprostenol sodium formulation

Bandilla D, Goverde M, Giudici P, Lambert O

Drug Design, Development and Therapy 2017, 11:2347-2357

Published Date: 10 August 2017

Isatin-benzoazine molecular hybrids as potential antiproliferative agents: synthesis and in vitro pharmacological profiling

Abdel-Aziz HA, Eldehna WM, Keeton AB, Piazza GA, Kadi AA, Attwa MW, Abdelhameed AS, Attia MI

Drug Design, Development and Therapy 2017, 11:2333-2346

Published Date: 9 August 2017

Modeling the human Nav1.5 sodium channel: structural and mechanistic insights of ion permeation and drug blockade

Ahmed M, Jalily Hasani H, Ganesan A, Houghton M, Barakat K

Drug Design, Development and Therapy 2017, 11:2301-2324

Published Date: 4 August 2017

Safety of switching from brand-name to generic levetiracetam in patients with epilepsy

Bosak M, Słowik A, Turaj W

Drug Design, Development and Therapy 2017, 11:2287-2291

Published Date: 3 August 2017

Intracellular trafficking of new anticancer therapeutics: antibody–drug conjugates

Kalim M, Chen J, Wang S, Lin C, Ullah S, Liang K, Ding Q, Chen S, Zhan JB

Drug Design, Development and Therapy 2017, 11:2265-2276

Published Date: 2 August 2017

Markers of oxidative/nitrosative stress and inflammation in lung tissue of rats exposed to different intravenous iron compounds

Toblli JE, Cao G, Giani JF, Dominici FP, Angerosa M

Drug Design, Development and Therapy 2017, 11:2251-2263

Published Date: 1 August 2017

Comparative analysis of essential oil composition of Iranian and Indian Nigella sativa L. extracted using supercritical fluid extraction and solvent extraction

Ghahramanloo KH, Kamalidehghan B, Akbari Javar H, Teguh Widodo R, Majidzadeh K, Noordin MI

Drug Design, Development and Therapy 2017, 11:2221-2226

Published Date: 28 July 2017

Antibiotic susceptibility, heteroresistance, and updated treatment strategies in Helicobacter pylori infection

Mascellino MT, Porowska B, De Angelis M, Oliva A

Drug Design, Development and Therapy 2017, 11:2209-2220

Published Date: 28 July 2017

Schisandrin B attenuates CCl4-induced liver fibrosis in rats by regulation of Nrf2-ARE and TGF-β/Smad signaling pathways

Chen QS, Zhang H, Cao Y, Li Y, Sun S, Zhang JP, Zhang GQ

Drug Design, Development and Therapy 2017, 11:2179-2191

Published Date: 26 July 2017

The modulation of enzyme indoleamine 2,3-dioxygenase from dendritic cells for the treatment of type 1 diabetes mellitus

Abram DM, Fernandes LGR, Ramos Filho ACS, Simioni PU

Drug Design, Development and Therapy 2017, 11:2171-2178

Published Date: 24 July 2017

Using dezocine to prevent etomidate-induced myoclonus: a meta-analysis of randomized trials

Zhu Y, Yang Y, Zhou C, Bao Z

Drug Design, Development and Therapy 2017, 11:2163-2170

Published Date: 18 July 2017

Efficacy and safety of direct-acting antiviral therapy in previous hard-to-treat patients with recurrent hepatitis C virus infection after liver transplantation: a real-world cohort

Bernuth S, Grimm D, Vollmar J, Darstein F, Mittler J, Heise M, Hoppe-Lotichius M, Galle PR, Lang H, Zimmermann T

Drug Design, Development and Therapy 2017, 11:2131-2138

Published Date: 12 July 2017

Clinical utility of evolocumab in the management of hyperlipidemia: patient selection and follow-up

Dixon DL, Buckley LF, Trankle CR, Kadariya D, Abbate A

Drug Design, Development and Therapy 2017, 11:2121-2129

Published Date: 11 July 2017

Evaluation of the stability of linezolid in aqueous solution and commonly used intravenous fluids

Taylor R, Sunderland B, Luna G, Czarniak P

Drug Design, Development and Therapy 2017, 11:2087-2097

Published Date: 10 July 2017

Spotlight on ceritinib in the treatment of ALK+ NSCLC: design, development and place in therapy

Santarpia M, Daffinà MG, D'Aveni A, Marabello G, Liguori A, Giovannetti E, Karachaliou N, Gonzalez Cao M, Rosell R, Altavilla G

Drug Design, Development and Therapy 2017, 11:2047-2063

Published Date: 5 July 2017

Development of highly potent melanogenesis inhibitor by in vitro, in vivo and computational studies

Abbas Q, Ashraf Z, Hassan M, Nadeem H, Latif M, Afzal S, Seo S

Drug Design, Development and Therapy 2017, 11:2029-2046

Published Date: 5 July 2017

Synthesis and antimicrobial activity of chiral quaternary N-spiro ammonium bromides with 3',4'-dihydro-1'H-spiro[isoindoline-2,2'-isoquinoline] skeleton

Bielawski K, Leszczyńska K, Kałuża Z, Bielawska A, Michalak O, Daniluk T, Staszewska-Krajewska O, Czajkowska A, Pawłowska N, Gornowicz A

Drug Design, Development and Therapy 2017, 11:2015-2028

Published Date: 5 July 2017

Targeted therapy in severe asthma today: focus on immunoglobulin E

Pelaia G, Canonica GW, Matucci A, Paolini R, Triggiani M, Paggiaro P

Drug Design, Development and Therapy 2017, 11:1979-1987

Published Date: 29 June 2017

Cell and small animal models for phenotypic drug discovery

Szabo M, Svensson Akusjärvi S, Saxena A, Liu J, Chandrasekar G, Kitambi SS

Drug Design, Development and Therapy 2017, 11:1957-1967

Published Date: 28 June 2017

Determining optimal dosing regimen of oral administration of dicloxacillin using Monte Carlo simulation

Yu W, Ji J, Xiao T, Ying C, Fang J, Shen P, Xiao Y

Drug Design, Development and Therapy 2017, 11:1951-1956

Published Date: 28 June 2017

Comparison of neurotoxic potency between a novel chinbotulinumtoxinA with onabotulinumtoxinA, incobotulinumtoxinA and lanbotulinumtoxinA in rats

Feng Y, Liu WC, Pan LZ, Jiang C, Zhang CX, Lu YX, Nie ZY, Jin LJ

Drug Design, Development and Therapy 2017, 11:1927-1939

Published Date: 28 June 2017

Effect of picroside II on hind limb ischemia reperfusion injury in rats

Kılıç Y, Özer A, Tatar T, Zor MH, Kirişçi M, Kartal H, Dursun AD, Billur D, Arslan M, Küçük A

Drug Design, Development and Therapy 2017, 11:1917-1925

Published Date: 26 June 2017

Antiglioma effects of cytarabine on leptomeningeal metastasis of high-grade glioma by targeting the PI3K/Akt/mTOR pathway

Zhao KH, Zhang C, Bai Y, Li Y, Kang X, Chen JX, Yao K, Jiang T, Zhong XS, Li WB

Drug Design, Development and Therapy 2017, 11:1905-1915

Published Date: 26 June 2017

Efficacy and safety of retinol palmitate ophthalmic solution in the treatment of dry eye: a Japanese Phase II clinical trial

Toshida H, Funaki T, Ono K, Tabuchi N, Watanabe S, Seki T, Otake H, Kato T, Ebihara N, Murakami A

Drug Design, Development and Therapy 2017, 11:1871-1879

Published Date: 23 June 2017

Molecular docking, QSAR and ADMET studies of withanolide analogs against breast cancer

Yadav DK, Kumar S, Saloni, Singh H, Kim M, Sharma P, Misra S, Khan F

Drug Design, Development and Therapy 2017, 11:1859-1870

Published Date: 22 June 2017

Differential effect of platelet-rich plasma fractions on β1-integrin signaling, collagen biosynthesis, and prolidase activity in human skin fibroblasts

Guszczyn T, Surażyński A, Zaręba I, Rysiak E, Popko J, Pałka J

Drug Design, Development and Therapy 2017, 11:1849-1857

Published Date: 22 June 2017

Enzymatic synthesis and in vitro evaluation of folate-functionalized liposomes

Guo B, Xu D, Liu X, Yi J

Drug Design, Development and Therapy 2017, 11:1839-1847

Published Date: 20 June 2017

Comparison of posttransplant outcomes in patients with no, acute, or chronic amiodarone use before heart transplantation

Rivinius R, Helmschrott M, Ruhparwar A, Darche FF, Thomas D, Bruckner T, Katus HA, Doesch AO

Drug Design, Development and Therapy 2017, 11:1827-1837

Published Date: 19 June 2017

Cryptotanshinone induces cell cycle arrest and apoptosis through the JAK2/STAT3 and PI3K/Akt/NFkB pathways in cholangiocarcinoma cells

Ke FY, Wang Z, Song XL, Ma Q, Hu YP, Jiang L, Zhang YJ, Liu YB, Zhang Y, Gong W

Drug Design, Development and Therapy 2017, 11:1753-1766

Published Date: 15 June 2017

Controlled release of optimized electroporation enhances the transdermal efficiency of sinomenine hydrochloride for treating arthritis in vitro and in clinic

Feng S, Zhu L, Huang Z, Wang H, Li H, Zhou H, Lu L, Wang Y, Liu Z, Liu L

Drug Design, Development and Therapy 2017, 11:1737-1752

Published Date: 15 June 2017

Efficacy of antibiotic treatment of implant-associated Staphylococcus aureus infections with moxifloxacin, flucloxacillin, rifampin, and combination therapy: an animal study

Greimel F, Scheuerer C, Gessner A, Simon M, Kalteis T, Grifka J, Benditz A, Springorum HR, Schaumburger J

Drug Design, Development and Therapy 2017, 11:1729-1736

Published Date: 14 June 2017

Lugano 2014 criteria for assessing FDG-PET/CT in lymphoma: an operational approach for clinical trials

Van Heertum RL, Scarimbolo R, Wolodzko JG, Klencke B, Messmann R, Tunc F, Sokol L, Agarwal R, Strafaci JA, O'Neal M

Drug Design, Development and Therapy 2017, 11:1719-1728

Published Date: 13 June 2017

Controlled-release nanoencapsulating microcapsules to combat inflammatory diseases

Baek JS, Yeo EW, Lee YH, Tan NS, Loo SCJ

Drug Design, Development and Therapy 2017, 11:1707-1717

Published Date: 8 June 2017

Development of new promising antimetabolite, DFP-11207 with self-controlled toxicity in rodents

Fukushima M, Iizuka K, Jin C, Zhang C, Hong M, Eshima K

Drug Design, Development and Therapy 2017, 11:1693-1705

Published Date: 7 June 2017

Renal function in heart transplant patients after switch to combined mammalian target of rapamycin inhibitor and calcineurin inhibitor therapy

Helmschrott M, Rivinius R, Bruckner T, Katus HA, Doesch AO

Drug Design, Development and Therapy 2017, 11:1673-1680

Published Date: 7 June 2017

Rhein attenuates inflammation through inhibition of NF-κB and NALP3 inflammasome in vivo and in vitro

Ge H, Tang H, Liang Y, Wu J, Yang Q, Zeng L, Ma Z

Drug Design, Development and Therapy 2017, 11:1663-1671

Published Date: 6 June 2017

CT-P13: design, development, and place in therapy

Gabbani T, Deiana S, Annese V

Drug Design, Development and Therapy 2017, 11:1653-1661

Published Date: 6 June 2017

Spotlight on ixekizumab for the treatment of moderate-to-severe plaque psoriasis: design, development, and use in therapy

Giunta A, Ventura A, Chimenti MS, Bianchi L, Esposito M

Drug Design, Development and Therapy 2017, 11:1643-1651

Published Date: 2 June 2017

Development of antiproliferative long-circulating liposomes co-encapsulating doxorubicin and curcumin, through the use of a quality-by-design approach

Tefas LR, Sylvester B, Tomuta I, Sesarman A, Licarete E, Banciu M, Porfire A

Drug Design, Development and Therapy 2017, 11:1605-1621

Published Date: 25 May 2017

Profile of sarilumab and its potential in the treatment of rheumatoid arthritis

Raimondo MG, Biggioggero M, Crotti C, Becciolini A, Favalli EG

Drug Design, Development and Therapy 2017, 11:1593-1603

Published Date: 24 May 2017

Effect of a food supplement containing berberine, monacolin K, hydroxytyrosol and coenzyme Q10 on lipid levels: a randomized, double-blind, placebo controlled study

D'Addato S, Scandiani L, Mombelli G, Focanti F, Pelacchi F, Salvatori E, Di Loreto G, Comandini A, Maffioli P, Derosa G

Drug Design, Development and Therapy 2017, 11:1585-1592

Published Date: 23 May 2017

Past and current perspective on new therapeutic targets for Type-II diabetes

Patil PD, Mahajan UB, Patil KR, Chaudhari S, Patil CR, Agrawal YO, Ojha S, Goyal SN

Drug Design, Development and Therapy 2017, 11:1567-1583

Published Date: 22 May 2017

Outcome of stroke patients receiving different doses of recombinant tissue plasminogen activator

Ong CT, Wong YS, Wu CS, Su YH

Drug Design, Development and Therapy 2017, 11:1559-1566

Published Date: 18 May 2017

Cisplatin induces protective autophagy through activation of BECN1 in human bladder cancer cells

Lin JF, Lin YC, Tsai TF, Chen HE, Chou KY, Hwang TIS

Drug Design, Development and Therapy 2017, 11:1517-1533

Published Date: 16 May 2017

Ten years of biosimilars in Europe: development and evolution of the regulatory pathways

Schiestl M, Zabransky M, Sörgel F

Drug Design, Development and Therapy 2017, 11:1509-1515

Published Date: 16 May 2017

Ten years of clinical experience with biosimilar human growth hormone: a review of safety data

Borrás Pérez MV, Kriström B, Romer T, Walczak M, Höbel N, Zabransky M

Drug Design, Development and Therapy 2017, 11:1497-1503

Published Date: 16 May 2017

Ten years' clinical experience with biosimilar human growth hormone: a review of efficacy data

López-Siguero JP, Pfäffle R, Chanson P, Szalecki M, Höbel N, Zabransky M

Drug Design, Development and Therapy 2017, 11:1489-1495

Published Date: 16 May 2017

Fabrication, characterization and in vitro evaluation of silibinin nanoparticles: an attempt to enhance its oral bioavailability

Sahibzada MUK, Sadiq A, Khan S, Faidah HS, Naseemullah, Khurram M, Amin MU, Haseeb A

Drug Design, Development and Therapy 2017, 11:1453-1464

Published Date: 15 May 2017

Preparation, characterization, and in vitro/vivo studies of oleanolic acid-loaded lactoferrin nanoparticles

Xia X, Liu H, Lv H, Zhang J, Zhou JP, Zhao Z

Drug Design, Development and Therapy 2017, 11:1417-1427

Published Date: 9 May 2017

Effect of epigallocatechin-3-gallate, major ingredient of green tea, on the pharmacokinetics of rosuvastatin in healthy volunteers

Kim TE, Ha N, Kim Y, Kim H, Lee JW, Jeon JY, Kim MG

Drug Design, Development and Therapy 2017, 11:1409-1416

Published Date: 9 May 2017

Propranolol therapy for infantile hemangioma: our experience

Zhang L, Wu HW, Yuan W, Zheng J

Drug Design, Development and Therapy 2017, 11:1401-1408

Published Date: 8 May 2017

Involvement of NF-κB and HSP70 signaling pathways in the apoptosis of MDA-MB-231 cells induced by a prenylated xanthone compound, α-mangostin, from Cratoxylum arborescens [Retraction]

Ibrahim MY, Hashim NM, Mohan S, Abdulla MA, Abdelwahab SI, Kamalidehghan B, Ghaderian M, Dehghan F, Ali LZ, Karimian H, Yahayu M, Ee GCL, Farjam AS, Ali HM

Drug Design, Development and Therapy 2017, 11:1399-1400

Published Date: 12 May 2017

Effect of electromagnetic fields and antioxidants on the trace element content of rat teeth

Dogan MS, Yavas MC, Yavuz Y, Erdogan S, Yener İ, Simsek İ, Akkus Z, Eratilla V, Tanik A, Akdag MZ

Drug Design, Development and Therapy 2017, 11:1393-1398

Published Date: 4 May 2017

Atorvastatin, a double weapon in osteoporosis treatment: an experimental and clinical study

El-Nabarawy N, El-Wakd M, Salem M

Drug Design, Development and Therapy 2017, 11:1383-1391

Published Date: 2 May 2017

Developing selective histone deacetylases (HDACs) inhibitors through ebselen and analogs

Wang Y, Wallach J, Duane S, Wang Y, Wu J, Wang J, Adejare A, Ma H

Drug Design, Development and Therapy 2017, 11:1369-1382

Published Date: 2 May 2017

Combined letrozole and clomiphene versus letrozole and clomiphene alone in infertile patients with polycystic ovary syndrome [Erratum]

Ghasemi-Rad M, Hajishafiha M, Dehghan M, Sadegh-Asadi N, Navid Shayegh S, Kiarang N

Drug Design, Development and Therapy 2017, 11:1367-1368

Published Date: 28 April 2017

Methanol leaf extract of Actinodaphne sesquipedalis (Lauraceae) enhances gastric defense against ethanol-induced ulcer in rats

Omar H, Nordin N, Hassandarvish P, Hajrezaie M, Azizan AHS, Fadaeinasab M, Abdul Majid N, Abdulla MA, Mohd Hashim N, Mohd Ali H

Drug Design, Development and Therapy 2017, 11:1353-1365

Published Date: 4 May 2017

Evaluation of the antitumor activity of NOV202, a novel microtubule targeting and vascular disrupting agent

Rickardson L, Kutvonen E, Orasniemi S, Högberg M, Kallio MJ, Rehnmark S

Drug Design, Development and Therapy 2017, 11:1335-1351

Published Date: 28 April 2017

Development and evaluation of a new modular nanotransporter for drug delivery into nuclei of pathological cells expressing folate receptors

Slastnikova TA, Rosenkranz AA, Khramtsov YV, Karyagina TS, Ovechko SA, Sobolev AS

Drug Design, Development and Therapy 2017, 11:1315-1334

Published Date: 26 April 2017

A first-in-human, double-blind, placebo-controlled, randomized, dose escalation study of DWP05195, a novel TRPV1 antagonist, in healthy volunteers

Lee J, Kim BH, Yu KS, Kim HS, Kim JD, Cho JY, Lee S, Gu N

Drug Design, Development and Therapy 2017, 11:1301-1313

Published Date: 24 April 2017

Proton-pump inhibitors use, and risk of acute kidney injury: a meta-analysis of observational studies

Yang Y, George KC, Shang WF, Zeng R, Ge SW, Xu G

Drug Design, Development and Therapy 2017, 11:1291-1299

Published Date: 24 April 2017

Functional characterization of wild-type and 24 CYP2D6 allelic variants on gefitinib metabolism in vitro

Fang P, Zheng X, He JY, Ge HL, Tang PF, Cai JP, Hu GX

Drug Design, Development and Therapy 2017, 11:1283-1290

Published Date: 21 April 2017

Anti-platelet effects of anti-glaucomatous eye drops: an in vitro study on human platelets

Moschos MM, Moustafa GA, Papakonstantinou VD, Tsatsos M, Laios K, Antonopoulou S

Drug Design, Development and Therapy 2017, 11:1267-1272

Published Date: 19 April 2017

Humanin rescues cultured rat cortical neurons from NMDA-induced toxicity through the alleviation of mitochondrial dysfunction

Cui A, Zhang Y, Li J, Song T, Liu X, Wang H, Zhang C, Ma G, Zhang H, Li K

Drug Design, Development and Therapy 2017, 11:1243-1253

Published Date: 18 April 2017

A comparative study on endovascular treatment of (sub)acute critical limb ischemia: mechanical thrombectomy vs thrombolysis

Kronlage M, Printz I, Vogel B, Blessing E, Müller OJ, Katus HA, Erbel C

Drug Design, Development and Therapy 2017, 11:1233-1241

Published Date: 18 April 2017

Vitamin D deficiency and tuberculosis: what about body mass index?

Hernández-Garduño E

Drug Design, Development and Therapy 2017, 11:1193-1194

Published Date: 11 April 2017

Bioequivalence study of a new sildenafil 100 mg orodispersible film compared to the conventional film-coated 100 mg tablet administered to healthy male volunteers

Radicioni M, Castiglioni C, Giori A, Cupone I, Frangione V, Rovati S

Drug Design, Development and Therapy 2017, 11:1183-1192

Published Date: 11 April 2017

Justification of disintegration testing beyond current FDA criteria using in vitro and in silico models

Uebbing L, Klumpp L, Webster GK, Löbenberg R

Drug Design, Development and Therapy 2017, 11:1163-1174

Published Date: 11 April 2017

Relaxin inhibits cardiac fibrosis and endothelial–mesenchymal transition via the Notch pathway [Corrigendum]

Zhou X, Chen X, Cai JJ, Chen LZ, Gong YS, Wang LX, Gao Z, Zhang HQ, Huang WJ, Zhou H

Drug Design, Development and Therapy 2017, 11:1159-1160

Published Date: 10 April 2017

Investigation of triamterene as an inhibitor of the TGR5 receptor: identification in cells and animals

Li Y, Cheng KC, Niu C, Lo S, Cheng JT, Niu H

Drug Design, Development and Therapy 2017, 11:1127-1134

Published Date: 5 April 2017

Phenotypic evaluation and in silico ADMET properties of novel arylimidamides in acute mouse models of Trypanosoma cruzi infection

da Silva CF, Batista DDGJ, de Araújo JS, Cunha-Junior EF, Stephens CE, Banerjee M, Farahat AA, Akay S, Fisher MK, Boykin DW, Soeiro MDNC

Drug Design, Development and Therapy 2017, 11:1095-1105

Published Date: 3 April 2017

Formulation, release characteristics, and bioavailability study of gastroretentive floating matrix tablet and floating raft system of Mebeverine HCl

El Nabarawi MA, Teaima MH, Abd El-Monem RA, El Nabarawy NA, Gaber DA

Drug Design, Development and Therapy 2017, 11:1081-1093

Published Date: 3 April 2017

Drug–drug interaction of microdose and regular-dose omeprazole with a CYP2C19 inhibitor and inducer

Park G, Bae SH, Park W, Han S, Park M, Shin S, Shin YG, Yim DS

Drug Design, Development and Therapy 2017, 11:1043-1053

Published Date: 30 March 2017

Mirtazapine for symptom control in refractory gastroparesis

Malamood M, Roberts A, Kataria R, Parkman HP, Schey R

Drug Design, Development and Therapy 2017, 11:1035-1041

Published Date: 30 March 2017

Rutin protects against neuronal damage in vitro and ameliorates doxorubicin-induced memory deficits in vivo in Wistar rats

Ramalingayya GV, Cheruku SP, Nayak PG, Kishore A, Shenoy R, Rao CM, Krishnadas N

Drug Design, Development and Therapy 2017, 11:1011-1026

Published Date: 29 March 2017

The antiulcer effect of Cibotium barometz leaves in rats with experimentally induced acute gastric ulcer

AL-Wajeeh NS, Hajrezaei M, Al-Henhena N, Kamran S, Bagheri E, Zahedifard M, Saremi K, Noor SM, Ali HM, Abdulla MA

Drug Design, Development and Therapy 2017, 11:995-1009

Published Date: 30 March 2017

An open randomized active-controlled clinical trial with low-dose SKA cytokines versus DMARDs evaluating low disease activity maintenance in patients with rheumatoid arthritis

Martin-Martin LS, Giovannangeli F, Bizzi E, Massafra U, Ballanti E, Cassol M, Migliore A

Drug Design, Development and Therapy 2017, 11:985-994

Published Date: 29 March 2017

Optimized formulation of multivesicular liposomes loaded with oleanolic acid enhanced anticancer effect in vitro

Wang Y, Luo Y, Li C, Zhang X, Pi C, Yu L, Wang S, Zhong Z

Drug Design, Development and Therapy 2017, 11:955-968

Published Date: 27 March 2017

Synergistic effects of antimicrobial peptide DP7 combined with antibiotics against multidrug-resistant bacteria

Wu X, Li Z, Li X, Tian Y, Fan Y, Yu C, Zhou B, Liu Y, Xiang R, Yang L

Drug Design, Development and Therapy 2017, 11:939-946

Published Date: 22 March 2017

Nanostructured lipid carriers for incorporation of copper(II) complexes to be used against Mycobacterium tuberculosis

Sato MR, Oshiro Junior JA, Machado RTA, de Souza PC, Campos DL, Pavan FR, da Silva PB, Chorilli M

Drug Design, Development and Therapy 2017, 11:909-921

Published Date: 20 March 2017

Clinical potential of SLAMF7 antibodies – focus on elotuzumab in multiple myeloma

Friend R, Bhutani M, Voorhees PM, Usmani SZ

Drug Design, Development and Therapy 2017, 11:893-900

Published Date: 20 March 2017

Delafloxacin: design, development and potential place in therapy

Candel FJ, Peñuelas M

Drug Design, Development and Therapy 2017, 11:881-891

Published Date: 20 March 2017

Artonin E induces p53-independent G1 cell cycle arrest and apoptosis through ROS-mediated mitochondrial pathway and livin suppression in MCF-7 cells

Etti IC, Rasedee A, Hashim NM, Abdul AB, Kadir A, Yeap SK, Waziri P, Malami I, Lim KL, Etti CJ

Drug Design, Development and Therapy 2017, 11:865-879

Published Date: 20 March 2017

Efficacy of cytokine-induced killer cell infusion as an adjuvant immunotherapy for hepatocellular carcinoma: a systematic review and meta-analysis

Yu R, Yang B, Chi X, Cai L, Liu C, Yang L, Wang X, He P, Lu X

Drug Design, Development and Therapy 2017, 11:851-864

Published Date: 17 March 2017

Cardioprotection with halogenated gases: how does it occur?

Guerrero-Orriach JL, Escalona Belmonte JJ, Ramirez Fernandez A, Ramirez Aliaga M, Rubio Navarro M, Cruz Mañas J

Drug Design, Development and Therapy 2017, 11:837-849

Published Date: 16 March 2017

Design, synthesis, and antimelanogenic effects of (2-substituted phenyl-1,3-dithiolan-4-yl)methanol derivatives

Kim DH, Kim SJ, Ullah S, Yun HY, Chun P, Moon HR

Drug Design, Development and Therapy 2017, 11:827-836

Published Date: 16 March 2017

Development of erythropoietin receptor-targeted drug delivery system against breast cancer using tamoxifen-loaded nanostructured lipid carriers

Beh CY, How CW, Foo JB, Foong JN, Selvarajah GT, Rasedee A

Drug Design, Development and Therapy 2017, 11:771-782

Published Date: 14 March 2017

Glycophenotype of breast and prostate cancer stem cells treated with thieno[2,3-b]pyridine anticancer compound

Mastelić A, Čikeš Čulić V, Režić Mužinić N, Vuica-Ross M, Barker D, Leung EY, Reynisson J, Markotić A

Drug Design, Development and Therapy 2017, 11:759-769

Published Date: 14 March 2017

An open-label, two-period comparative study on pharmacokinetics and safety of a combined ethinylestradiol/gestodene transdermal contraceptive patch

Zhang C, Li H, Xiong X, Zhai S, Wei Y, Zhang S, Zhang Y, Xu L, Liu L

Drug Design, Development and Therapy 2017, 11:725-731

Published Date: 10 March 2017

Pharmacokinetics and tolerability of DA-8031, a novel selective serotonin reuptake inhibitor for premature ejaculation in healthy male subjects

Shin D, Lee S, Yi S, Yoon SH, Cho JY, Bahng MY, Jang IJ, Yu KS

Drug Design, Development and Therapy 2017, 11:713-723

Published Date: 10 March 2017

Effects of dexamethasone coadministered with oseltamivir on the pharmacokinetics of oseltamivir in healthy volunteers

Jang K, Kim M, Oh J, Lee S, Cho JY, Yu KS, Choi TK, Lee SH, Lim KS

Drug Design, Development and Therapy 2017, 11:705-711

Published Date: 9 March 2017

Transcriptome analysis of endometrial tissues following GnRH agonist treatment in a mouse adenomyosis model

Guo S, Lu X, Gu R, Zhang D, Sun Y, Feng Y

Drug Design, Development and Therapy 2017, 11:695-704

Published Date: 9 March 2017

Development of venetoclax for therapy of lymphoid malignancies

Zhu H, Almasan A

Drug Design, Development and Therapy 2017, 11:685-694

Published Date: 9 March 2017

Does remifentanil attenuate renal ischemia–reperfusion injury better than dexmedetomidine in rat kidney?

Erkılıç E, Kesimci E, Alaybeyoğlu F, Kılınç I, Tural R, Yazgan A, Gümüş T, Sepici Dinçel A, Dumlu EG, Kanbak O

Drug Design, Development and Therapy 2017, 11:677-683

Published Date: 8 March 2017

Protective influence of hyaluronic acid on focal adhesion kinase activity in human skin fibroblasts exposed to ethanol

Donejko M, Rysiak E, Galicka E, Terlikowski R, Głażewska EK, Przylipiak A

Drug Design, Development and Therapy 2017, 11:669-676

Published Date: 6 March 2017

Paclitaxel-loaded star-shaped copolymer nanoparticles for enhanced malignant melanoma chemotherapy against multidrug resistance

Su Y, Hu J, Huang Z, Huang Y, Peng B, Xie N, Liu H

Drug Design, Development and Therapy 2017, 11:659-668

Published Date: 6 March 2017

New developments in the management of partial-onset epilepsy: role of brivaracetam

Coppola G, Iapadre G, Operto FF, Verrotti A

Drug Design, Development and Therapy 2017, 11:643-657

Published Date: 6 March 2017

MC-PPEA as a new and more potent inhibitor of CLP-induced sepsis and pulmonary inflammation than FK866

Huang P, Lee Jr MW, Sadrerafi K, Heruth DP, Zhang LQ, Maulik D, Ye SQ

Drug Design, Development and Therapy 2017, 11:629-641

Published Date: 3 March 2017

Metal complexes in cancer therapy – an update from drug design perspective

Ndagi U, Mhlongo N, Soliman ME

Drug Design, Development and Therapy 2017, 11:599-616

Published Date: 3 March 2017

Awake craniotomy anesthetic management using dexmedetomidine, propofol, and remifentanil

Prontera A, Baroni S, Marudi A, Valzania F, Feletti A, Benuzzi F, Bertellini E, Pavesi G

Drug Design, Development and Therapy 2017, 11:593-598

Published Date: 3 March 2017

Human papillomavirus (HPV): systemic treatment with Gene-Eden-VIR/Novirin safely and effectively clears virus

Polansky H, Itzkovitz E, Javaherian A

Drug Design, Development and Therapy 2017, 11:575-583

Published Date: 3 March 2017

In silico discovery and in vitro activity of inhibitors against Mycobacterium tuberculosis 7,8-diaminopelargonic acid synthase (Mtb BioA)

Billones JB, Carrillo MCO, Organo VG, Sy JBA, Clavio NAB, Macalino SJY, Emnacen IA, Lee AP, Ko PKL, Concepcion GP

Drug Design, Development and Therapy 2017, 11:563-574

Published Date: 2 March 2017

Adenosine A2A  receptor agonist prevents cardiac remodeling and dysfunction in spontaneously hypertensive male rats after myocardial infarction

da Silva JS, Gabriel-Costa D, Sudo RT, Wang H, Groban L, Ferraz EB, Nascimento JHM, Fraga CAM, Barreiro EJ, Zapata-Sudo G

Drug Design, Development and Therapy 2017, 11:553-562

Published Date: 6 March 2017

Defective DNA repair mechanisms in prostate cancer: impact of olaparib

De Felice F, Tombolini V, Marampon F, Musella A, Marchetti C

Drug Design, Development and Therapy 2017, 11:547-552

Published Date: 1 March 2017

Eteplirsen in the treatment of Duchenne muscular dystrophy

Lim KRQ, Maruyama R, Yokota T

Drug Design, Development and Therapy 2017, 11:533-545

Published Date: 28 February 2017

Sofosbuvir/velpatasvir regimen promises an effective pan-genotypic hepatitis C virus cure

Mir F, Kahveci AS, Ibdah JA, Tahan V

Drug Design, Development and Therapy 2017, 11:497-502

Published Date: 23 February 2017

Polyphosphoester nanoparticles as biodegradable platform for delivery of multiple drugs and siRNA

Elzeny H, Zhang F, Ali EN, Fathi HA, Zhang S, Li R, El-Mokhtar MA, Hamad MA, Wooley KL, Elsabahy M

Drug Design, Development and Therapy 2017, 11:483-496

Published Date: 22 February 2017

Antiproliferation effect of imatinib mesylate on MCF7, T-47D tumorigenic and MCF 10A nontumorigenic breast cell lines via PDGFR-β, PDGF-BB, c-Kit and SCF genes

Kadivar A, Kamalidehghan B, Akbari Javar H, Karimi B, Sedghi R, Noordin MI

Drug Design, Development and Therapy 2017, 11:469-481

Published Date: 21 February 2017

Insight into resistance mechanisms of AZD4547 and E3810 to FGFR1 gatekeeper mutation via theoretical study

Liang D, Chen Q, Guo Y, Zhang T, Guo W

Drug Design, Development and Therapy 2017, 11:451-461

Published Date: 17 February 2017

Reversal of multidrug resistance in human lung cancer cells by delivery of 3-octadecylcarbamoylacrylic acid–cisplatin-based liposomes

Song J, Ren W, Xu T, Zhang Y, Guo H, Zhu S, Yang L

Drug Design, Development and Therapy 2017, 11:441-449

Published Date: 17 February 2017

Curcumin induces apoptosis and protective autophagy in castration-resistant prostate cancer cells through iron chelation

Yang C, Ma X, Wang Z, Zeng X, Hu Z, Ye Z, Shen G

Drug Design, Development and Therapy 2017, 11:431-439

Published Date: 14 February 2017

Novel 5-oxo-hexahydroquinoline derivatives: design, synthesis, in vitro P-glycoprotein-mediated multidrug resistance reversal profile and molecular dynamics simulation study

Shahraki O, Edraki N, Khoshneviszadeh M, Zargari F, Ranjbar S, Saso L, Firuzi O, Miri R

Drug Design, Development and Therapy 2017, 11:407-418

Published Date: 14 February 2017

Oral and transdermal drug delivery systems: role of lipid-based lyotropic liquid crystals

Rajabalaya R, Musa MN, Kifli N, David SR

Drug Design, Development and Therapy 2017, 11:393-406

Published Date: 13 February 2017

Antioxidant compounds and activities of the stem, flower, and leaf extracts of the anti-smoking Thai medicinal plant: Vernonia cinerea Less

Ketsuwan N, Leelarungrayub J, Kothan S, Singhatong S

Drug Design, Development and Therapy 2017, 11:383-391

Published Date: 13 February 2017

Pharmacokinetics of conivaptan use in patients with severe hepatic impairment

Marbury T, Fox J, Kaelin B, Pavliv L

Drug Design, Development and Therapy 2017, 11:373-382

Published Date: 13 February 2017

Gancidin W, a potential low-toxicity antimalarial agent isolated from an endophytic Streptomyces SUK10

Zin NM, Baba MS, Zainal-Abidin AH, Latip J, Mazlan NW, Edrada-Ebel R

Drug Design, Development and Therapy 2017, 11:351-363

Published Date: 8 February 2017

Kelussia odoratissima Mozaff. activates intrinsic pathway of apoptosis in breast cancer cells associated with S phase cell cycle arrest via involvement of p21/p27 in vitro and in vivo

Karimian H, Arya A, Fadaeinasab M, Razavi M, Hajrezaei M, Karim Khan A, Mohd Ali H, Abdulla MA, Noordin MI

Drug Design, Development and Therapy 2017, 11:337-350

Published Date: 1 February 2017

Drug delivery in overcoming the blood–brain barrier: role of nasal mucosal grafting

Marianecci C, Rinaldi F, Hanieh PN, Di Marzio L, Paolino D, Carafa M

Drug Design, Development and Therapy 2017, 11:325-335

Published Date: 27 January 2017

Phloretin exerts hypoglycemic effect in streptozotocin-induced diabetic rats and improves insulin resistance in vitro

Shen X, Zhou N, Mi L, Hu Z, Wang L, Liu X, Zhang S

Drug Design, Development and Therapy 2017, 11:313-324

Published Date: 7 February 2017

Obinutuzumab in chronic lymphocytic leukemia: design, development and place in therapy

Al-Sawaf O, Fischer K, Engelke A, Pflug N, Hallek M, Goede V

Drug Design, Development and Therapy 2017, 11:295-304

Published Date: 25 January 2017

Theophylline action on primary human bronchial epithelial cells under proinflammatory stimuli and steroidal drugs: a therapeutic rationale approach

Gallelli L, Falcone D, Cannataro R, Perri M, Serra R, Pelaia G, Maselli R, Savino R, Spaziano G, D’Agostino B

Drug Design, Development and Therapy 2017, 11:265-272

Published Date: 23 January 2017

Plitidepsin: design, development, and potential place in therapy

Alonso-Álvarez S, Pardal E, Sánchez-Nieto D, Navarro M, Caballero MD, Mateos MV, Martín A

Drug Design, Development and Therapy 2017, 11:253-264

Published Date: 19 January 2017

Effect of roll compaction on granule size distribution of microcrystalline cellulose–mannitol mixtures: computational intelligence modeling and parametric analysis

Kazemi P, Khalid MH, Pérez Gago A, Kleinebudde P, Jachowicz R, Szlęk J, Mendyk A

Drug Design, Development and Therapy 2017, 11:241-251

Published Date: 18 January 2017

N-(3-hydroxymethyl-β-carboline-1-yl-ethyl-2-yl)-L-Phe: development toward a nanoscaled antitumor drug capable of treating complicated thrombosis and inflammation

Wu JH, Zhao M, Wang YJ, Wang YN, Zhu HM, Zhao SR, Gui L, Zhang XY, Peng SQ

Drug Design, Development and Therapy 2017, 11:225-239

Published Date: 17 January 2017

Spotlight on mavrilimumab for the treatment of rheumatoid arthritis: evidence to date

Crotti C, Raimondo MG, Becciolini A, Biggioggero M, Favalli EG

Drug Design, Development and Therapy 2017, 11:211-223

Published Date: 13 January 2017

Comparison of the long-term efficacy and safety of generic Tacrobell with original tacrolimus (Prograf) in kidney transplant recipients

Son SY, Jang HR, Lee JE, Yoo H, Kim K, Park JB, Kim SJ, Oh HY, Huh W

Drug Design, Development and Therapy 2017, 11:203-210

Published Date: 12 January 2017

Computational intelligence models to predict porosity of tablets using minimum features

Khalid MH, Kazemi P, Perez-Gandarillas L, Michrafy A, Szlęk J, Jachowicz R, Mendyk A

Drug Design, Development and Therapy 2017, 11:193-202

Published Date: 12 January 2017

Evaluation of a 2-aminoimidazole variant as adjuvant treatment for dermal bacterial infections

Draughn GL, Allen CL, Routh PA, Stone MR, Kirker KR, Boegli L, Schuchman RM, Linder KE, Baynes RE, James G, Melander C, Pollard A, Cavanagh J

Drug Design, Development and Therapy 2017, 11:153-162

Published Date: 11 January 2017

Pharmacokinetic and pharmacodynamic evaluation according to absorption differences in three formulations of ibuprofen

Shin D, Lee SJ, Ha Y, Choi YS, Kim JW, Park SR, Park MK

Drug Design, Development and Therapy 2017, 11:135-141

Published Date: 4 January 2017

A triazole derivative elicits autophagic clearance of polyglutamine aggregation in neuronal cells [Corrigendum]

Hsieh CH, Lee LC, Leong WY, Yang TC, Yao CF, Fang K

Drug Design, Development and Therapy 2017, 11:133-134

Published Date: 28 December 2016

Effects of multiple-dose ponesimod, a selective S1P1 receptor modulator, on lymphocyte subsets in healthy humans

Jurcevic S, Juif PE, Hamid C, Greenlaw R, D'Ambrosio D, Dingemanse J

Drug Design, Development and Therapy 2017, 11:123-131

Published Date: 28 December 2016

Anticancer and anti-inflammatory activities of girinimbine isolated from Murraya koenigii

Iman V, Mohan S, Abdelwahab SI, Karimian H, Nordin N, Fadaeinasab M, Noordin MI, Noor SM

Drug Design, Development and Therapy 2017, 11:103-121

Published Date: 28 December 2016

Vitamin D deficiency and the risk of tuberculosis: a meta-analysis

Huang SJ, Wang XH, Liu ZD, Cao WL, Han Y, Ma AG, Xu SF

Drug Design, Development and Therapy 2017, 11:91-102

Published Date: 28 December 2016

Analysis of pramipexole dose–response relationships in Parkinson's disease

Wang Y, Sun SG, Zhu SQ, Liu CF, Liu YM, Di Q, Shang HF, Ren Y, Xiang W, Chen SD

Drug Design, Development and Therapy 2017, 11:83-89

Published Date: 23 December 2016

Development of a chitosan based double layer-coated tablet as a platform for colon-specific drug delivery

Kim MS, Yeom DW, Kim SR, Yoon HY, Kim CH, Son HY, Kim JH, Lee S, Choi YW

Drug Design, Development and Therapy 2017, 11:45-57

Published Date: 21 December 2016

Spotlight on the 9-valent HPV vaccine

Lopalco PL

Drug Design, Development and Therapy 2017, 11:35-44

Published Date: 20 December 2016

Gastroretentive behavior of orally administered radiolabeled tamarind seed formulations in rabbits validated by gamma scintigraphy

Razavi M, Karimian H, Yeong CH, Fadaeinasab M, Khaing SL, Chung LY, Mohamad Haron DE, Noordin MI

Drug Design, Development and Therapy 2017, 11:1-15

Published Date: 19 December 2016

Folic acid-conjugated amphiphilic alternating copolymer as a new active tumor targeting drug delivery platform

Li X, Szewczuk MR, Malardier-Jugroot C

Drug Design, Development and Therapy 2016, 10:4101-4110

Published Date: 15 December 2016

Structure-based virtual screening and characterization of a novel IL-6 antagonistic compound from synthetic compound database

Wang J, Qiao C, Xiao H, Lin Z, Li Y, Zhang J, Shen B, Fu T, Feng J

Drug Design, Development and Therapy 2016, 10:4091-4100

Published Date: 15 December 2016

Protective effects of vitamin C and vitamin E against hysterosalpingography-induced epithelial degeneration and proliferation in rat endometrium

Pala Ş, Atilgan R, Kuloğlu T, Kara M, Başpınar M, Can B, Artaş G

Drug Design, Development and Therapy 2016, 10:4079-4089

Published Date: 15 December 2016

Design and in vitro/in vivo evaluation of sustained-release floating tablets of itopride hydrochloride

Ahmed SM, Ahmed Ali A, Ali AMA, Hassan OA

Drug Design, Development and Therapy 2016, 10:4061-4071

Published Date: 14 December 2016

Comparison of oral absorption models for pregabalin: usefulness of transit compartment model

Hong T, Han S, Lee J, Jeon S, Yim DS

Drug Design, Development and Therapy 2016, 10:3995-4003

Published Date: 7 December 2016

Impact of prostaglandin glaucoma drops on platelet-activating factor action: an in vitro study

Moschos MM, Nitoda E, Chatziralli IP, Panos GD, Demopoulos CA

Drug Design, Development and Therapy 2016, 10:3977-3981

Published Date: 7 December 2016

Paracetamol sharpens reflection and spatial memory: a double-blind randomized controlled study in healthy volunteers

Pickering G, Macian N, Dubray C, Pereira B

Drug Design, Development and Therapy 2016, 10:3969-3976

Published Date: 5 December 2016

Dose-dependent effects of cisplatin on the severity of testicular injury in Sprague Dawley rats: reactive oxygen species and endoplasmic reticulum stress

Soni KK, Kim HK, Choi BR, Karna KK, You JH, Cha JS, Shin YS, Lee SW, Kim CY, Park JK

Drug Design, Development and Therapy 2016, 10:3959-3968

Published Date: 12 December 2016

Increased therapeutic efficacy of a newly synthesized tyrosinase inhibitor by solid lipid nanoparticles in the topical treatment of hyperpigmentation

Al-Amin M, Cao J, Naeem M, Banna H, Kim M, Jung Y, Chung HY, Moon HR, Yoo J

Drug Design, Development and Therapy 2016, 10:3947-3957

Published Date: 2 December 2016

Loading cisplatin onto 6-mercaptopurine covalently modified MSNS: a nanomedicine strategy to improve the outcome of cisplatin therapy

Lv X, Zhao M, Wang Y, Hu X, Wu J, Jiang X, Li S, Cui C, Peng S

Drug Design, Development and Therapy 2016, 10:3933-3946

Published Date: 1 December 2016

Effect of peritoneal dialysis fluid containing osmo-metabolic agents on human endothelial cells

Bonomini M, Di Silvestre S, Di Tomo P, Di Pietro N, Mandatori D, Di Liberato L, Sirolli V, Chiarelli F, Indiveri C, Pandolfi A, Arduini A

Drug Design, Development and Therapy 2016, 10:3925-3932

Published Date: 28 November 2016

Statistical modeling methods to analyze the impacts of multiunit process variability on critical quality attributes of Chinese herbal medicine tablets

Sun F, Xu B, Zhang Y, Dai SY, Yang C, Cui XL, Shi XY, Qiao YJ

Drug Design, Development and Therapy 2016, 10:3909-3924

Published Date: 28 November 2016

Non-imidazole-based histamine H3 receptor antagonists with anticonvulsant activity in different seizure models in male adult rats

Sadek B, Saad A, Latacz G, Kuder K, Olejarz A, Karcz T, Stark H, Kieć-Kononowicz K

Drug Design, Development and Therapy 2016, 10:3879-3898

Published Date: 25 November 2016

Design, synthesis and evaluation of VEGF-siRNA/CRS as a novel vector for gene delivery

Zhao W, Zhang YF, Jiang XY, Cui CY

Drug Design, Development and Therapy 2016, 10:3851-3865

Published Date: 24 November 2016

Smart nanocrystals of artemether: fabrication, characterization, and comparative in vitro and in vivo antimalarial evaluation

Shah SMH, Ullah F, Khan S, Shah SMM, Matas MD, Hussain Z, Minhas MU, AbdEl-Salam NM, Assi KH, Isreb M

Drug Design, Development and Therapy 2016, 10:3837-3850

Published Date: 24 November 2016

Feasibility of sequential adjuvant chemotherapy with a 3-month oxaliplatin-based regimen followed by 3 months of capecitabine in patients with stage III and high-risk stage II colorectal cancer: JSWOG-C2 study

Tsuruta A, Yamashita K, Tanioka H, Tsuji A, Inukai M, Yamakawa T, Yamatsuji T, Yoshimitsu M, Toyota K, Yamano T, Nagasaka T, Okajima M

Drug Design, Development and Therapy 2016, 10:3827-3835

Published Date: 23 November 2016

Fabrication of anti-vitiligo ointment containing Psoralea corylifolia: in vitro and in vivo characterization

Hussain I, Hussain N, Manan A, Rashid A, Khan B, Bukhsh S

Drug Design, Development and Therapy 2016, 10:3805-3816

Published Date: 22 November 2016

CARD9 as a potential target in cardiovascular disease

Peterson MR, Haller SE, Ren J, Nair S, He G

Drug Design, Development and Therapy 2016, 10:3799-3804

Published Date: 22 November 2016

Comparison of bile salt/phosphatidylcholine mixed micelles in solubilization to sterols and stability

Guo Q, Cai J, Li PY, Xu DL, Ni XM, Wen H, Liu D, Lin SZ, Hu HY

Drug Design, Development and Therapy 2016, 10:3789-3798

Published Date: 17 November 2016

Increased localized delivery of piroxicam by cationic nanoparticles after intra-articular injection

Kim SR, Ho MJ, Kim SH, Cho HR, Kim HS, Choi YS, Choi YW, Kang MJ

Drug Design, Development and Therapy 2016, 10:3779-3787

Published Date: 16 November 2016

Dietary arginine silicate inositol complex inhibits periodontal tissue loss in rats with ligature-induced periodontitis

Dundar S, Eltas A, Hakki SS, Malkoc S, Uslu MO, Tuzcu M, Komorowski J, Ozercan IH, Akdemir F, Sahin K

Drug Design, Development and Therapy 2016, 10:3771-3778

Published Date: 15 November 2016

Pharmacokinetics, pharmacodynamics and safety of CKD-519, a CETP inhibitor, in healthy subjects

Kim CO, Oh ES, Choi CG, Kim YJ, Lee S, Kim S, Park MS

Drug Design, Development and Therapy 2016, 10:3763-3770

Published Date: 15 November 2016

Oncolytic adenovirus expressing interleukin-18 improves antitumor activity of dacarbazine for malignant melanoma

Yang C, Cao H, Liu N, Xu K, Ding M, Mao LJ

Drug Design, Development and Therapy 2016, 10:3755-3761

Published Date: 15 November 2016

Lentivirus-mediated knockdown of NLK inhibits small-cell lung cancer growth and metastasis

Lv MT, Li YM, Tian X, Dai SD, Sun J, Jin GJ, Jiang SY

Drug Design, Development and Therapy 2016, 10:3737-3746

Published Date: 15 November 2016

Systematic review and meta-analysis of randomized controlled trials on Wenxin keli

Wang XY, Wang Y, Feng XY, Lu Y, Zhang Y, Wang WW, Zhu WT

Drug Design, Development and Therapy 2016, 10:3725-3736

Published Date: 14 November 2016

Low-dose modified-release prednisone in axial spondyloarthritis: 3-month efficacy and tolerability

Bandinelli F, Scazzariello F, Pimenta da Fonseca E, Barreto Santiago M, Marcassa C, Nacci F, Matucci Cerinic M

Drug Design, Development and Therapy 2016, 10:3717-3724

Published Date: 14 November 2016

Effects of resveratrol on P-glycoprotein and cytochrome P450 3A in vitro and on pharmacokinetics of oral saquinavir in rats

Li JP, Liu Y, Zhang JR, Yu XT, Wang XL, Zhao LB

Drug Design, Development and Therapy 2016, 10:3699-3706

Published Date: 15 November 2016

Study of the antibacterial and antifungal activities of synthetic benzyl bromides, ketones, and corresponding chalcone derivatives

Shakhatreh MA, Al-Smadi ML, Khabour OF, Shuaibu FA, Hussein EI, Alzoubi KH

Drug Design, Development and Therapy 2016, 10:3653-3660

Published Date: 8 November 2016

Anticonvulsant effects of isomeric nonimidazole histamine H3 receptor antagonists

Sadek B, Saad A, Schwed JS, Weizel L, Walter M, Stark H

Drug Design, Development and Therapy 2016, 10:3633-3651

Published Date: 7 November 2016

Mechanism and pharmacological rescue of berberine-induced hERG channel deficiency [Corrigendum]

Yan M, Zhang KP, Shi YH, Feng LF, Lv L, Li BX

Drug Design, Development and Therapy 2016, 10:3573-3574

Published Date: 1 November 2016

Evaluating the cytotoxic effects of the water extracts of four anticancer herbs against human malignant melanoma cells

Ling BB, Michel D, Sakharkar MK, Yang J

Drug Design, Development and Therapy 2016, 10:3563-3572

Published Date: 1 November 2016

Effects of renal function on pharmacokinetics and pharmacodynamics of lesinurad in adult volunteers

Gillen M, Valdez S, Zhou D, Kerr B, Lee CA, Shen Z

Drug Design, Development and Therapy 2016, 10:3555-3562

Published Date: 1 November 2016

Mimetics of brain-derived neurotrophic factor loops 1 and 4 are active in a model of ischemic stroke in rats

Gudasheva TA, Povarnina P, Logvinov IO, Antipova TA, Seredenin SB

Drug Design, Development and Therapy 2016, 10:3545-3553

Published Date: 2 November 2016

Synthesis, anti-inflammatory, analgesic, COX1/2-inhibitory activity, and molecular docking studies of hybrid pyrazole analogues

Alam MJ, Alam O, Khan SA, Naim MJ, Islamuddin M, Deora GS

Drug Design, Development and Therapy 2016, 10:3529-3543

Published Date: 31 October 2016

Supratherapeutic dose evaluation and effect of lesinurad on cardiac repolarization: a thorough QT/QTc study

Shen Z, Gillen M, Tieu K, Nguyen M, Harmon E, Wilson DM, Kerr B, Lee CA

Drug Design, Development and Therapy 2016, 10:3509-3517

Published Date: 27 October 2016

Cardioprotective activity of placental growth factor combined with oral supplementation of L-arginine in a rat model of acute myocardial infarction

Luo L, Chen B, Huang Y, Liang Z, Li S, Yin Y, Chen J, Wu W

Drug Design, Development and Therapy 2016, 10:3483-3492

Published Date: 28 October 2016

Clinical utility of lanreotide Autogel® in gastroenteropancreatic neuroendocrine tumors

Paragliola RM, Prete A, Papi G, Torino F, Corsello A, Pontecorvi A, Corsello SM

Drug Design, Development and Therapy 2016, 10:3459-3470

Published Date: 25 October 2016

α-Aminoadipic acid protects against retinal disruption through attenuating Müller cell gliosis in a rat model of acute ocular hypertension

Wang X, Su J, Ding J, Han S, Ma W, Luo H, Hughes G, Meng Z, Yin Y, Wang Y, Li J

Drug Design, Development and Therapy 2016, 10:3449-3457

Published Date: 20 October 2016

Diminazene aceturate: an antibacterial agent for Shiga-toxin-producing Escherichia coli O157:H7

Wu SY, Park GY, Kim SH, Hulme J, An SSA

Drug Design, Development and Therapy 2016, 10:3363-3378

Published Date: 14 October 2016

Development of a microparticle-based dry powder inhalation formulation of ciprofloxacin hydrochloride applying the quality by design approach

Karimi K, Pallagi E, Szabó-Révész P, Csóka I, Ambrus R

Drug Design, Development and Therapy 2016, 10:3331-3343

Published Date: 12 October 2016

The expression of HoxB5 and SPC in neonatal rat lung at exposure to fluoxetine

Taghizadeh R, Taghipour Z, Karimi A, Shamsizadeh A, Taghavi MM, Shariati M, Shabanizadeh A, Jafari Naveh HR, Bidaki R, Aminzadeh F

Drug Design, Development and Therapy 2016, 10:3323-3329

Published Date: 2 November 2016

Moringin activates Wnt canonical pathway by inhibiting GSK3β in a mouse model of experimental autoimmune encephalomyelitis

Giacoppo S, Soundara Rajan T, De Nicola GR, Iori R, Bramanti P, Mazzon E

Drug Design, Development and Therapy 2016, 10:3291-3304

Published Date: 4 October 2016

Stability of apomorphine in solutions containing selected antioxidant agents

Ang ZY, Boddy M, Liu Y, Sunderland B

Drug Design, Development and Therapy 2016, 10:3253-3265

Published Date: 3 October 2016

Homology modeling, molecular dynamics, and virtual screening of NorA efflux pump inhibitors of Staphylococcus aureus

Bhaskar BV, Babu TMC, Reddy NV, Rajendra W

Drug Design, Development and Therapy 2016, 10:3237-3252

Published Date: 3 October 2016

Druggability analysis and classification of protein tyrosine phosphatase active sites

Ghattas MA, Raslan N, Sadeq A, Al Sorkhy M, Atatreh N

Drug Design, Development and Therapy 2016, 10:3197-3209

Published Date: 30 September 2016

Looking for inhibitors of the dengue virus NS5 RNA-dependent RNA-polymerase using a molecular docking approach

Galiano V, Garcia-Valtanen P, Micol V, Encinar JA

Drug Design, Development and Therapy 2016, 10:3163-3181

Published Date: 11 October 2016

Incidence and risk of hepatic toxicities with PD-1 inhibitors in cancer patients: a meta-analysis

Zhang X, Ran Y, Wang K, Zhu Y, Li J

Drug Design, Development and Therapy 2016, 10:3153-3161

Published Date: 28 September 2016

Resolvins and aliamides: lipid autacoids in ophthalmology – what promise do they hold?

Hesselink JMK, Chiosi F, Costagliola C

Drug Design, Development and Therapy 2016, 10:3133-3141

Published Date: 27 September 2016

Pharmacokinetics, absorption, and excretion of radiolabeled revexepride: a Phase I clinical trial using a microtracer and accelerator mass spectrometry-based approach

Flach S, Croft M, Ding J, Budhram R, Pankratz T, Pennick M, Scarfe G, Troy S, Getsy J

Drug Design, Development and Therapy 2016, 10:3125-3132

Published Date: 27 September 2016

Structural insights into the polypharmacological activity of quercetin on serine/threonine kinases

Baby B, Antony P, Al Halabi W, Al Homedi Z, Vijayan R

Drug Design, Development and Therapy 2016, 10:3109-3123

Published Date: 27 September 2016

Spotlight on sirukumab for the treatment of rheumatoid arthritis: the evidence to date

Lazzerini PE, Capecchi PL, Guidelli GM, Selvi E, Acampa M, Laghi-Pasini F

Drug Design, Development and Therapy 2016, 10:3083-3098

Published Date: 26 September 2016

Formononetin, an active compound of Astragalus membranaceus (Fisch) Bunge, inhibits hypoxia-induced retinal neovascularization via the HIF-1α/VEGF signaling pathway

Wu J, Ke X, Ma N, Wang W, Fu W, Zhang H, Zhao M, Gao X, Hao X, Zhang Z

Drug Design, Development and Therapy 2016, 10:3071-3081

Published Date: 23 September 2016

Efficacy of an acquainted drug in the treatment of inflammatory low back pain: sulfasalazine under investigation

Moghimi J, Rezaei AA, Ghorbani R, Razavi MR, Pahlevan D

Drug Design, Development and Therapy 2016, 10:3065-3069

Published Date: 23 September 2016

TopBP1 contributes to the chemoresistance in non-small cell lung cancer through upregulation of p53

Lv Y, Huo Y, Yu X, Liu R, Zhang S, Zheng X, Zhang X

Drug Design, Development and Therapy 2016, 10:3053-3064

Published Date: 23 September 2016

Controlled release of TGF-beta 1 from RADA self-assembling peptide hydrogel scaffolds

Zhou A, Chen S, He B, Zhao W, Chen X, Jiang D

Drug Design, Development and Therapy 2016, 10:3043-3051

Published Date: 22 September 2016

Effect of low dose of intrathecal pethidine on the incidence and intensity of shivering during cesarean section under spinal anesthesia: a randomized, placebo-controlled, double-blind clinical trial

Shami S, Nasseri K, Shirmohammadi M, Sarshivi F, Ghadami N, Ghaderi E, Pouladi M, Barzanji A

Drug Design, Development and Therapy 2016, 10:3005-3012

Published Date: 20 September 2016

Profile of adalimumab and its potential in the treatment of uveitis

Balevic SJ, Rabinovich CE

Drug Design, Development and Therapy 2016, 10:2997-3003

Published Date: 19 September 2016

Radiolabeled tirofiban – a potential radiopharmaceutical for detection of deep venous thrombosis

Darkovska-Serafimovska M, Janevik-Ivanovska E, Djorgoski I, Arsova-Sarafinovska Z, Zdravkovska M, Balkanov T, Ugresic N

Drug Design, Development and Therapy 2016, 10:2989-2996

Published Date: 21 September 2016

Combined computational and experimental studies of molecular interactions of albuterol sulfate with bovine serum albumin for pulmonary drug nanoparticles

Lin SH, Cui W, Wang GL, Meng S, Liu YC, Jin HW, Zhang LR, Xie Y

Drug Design, Development and Therapy 2016, 10:2973-2987

Published Date: 15 September 2016

Application of physiologically based pharmacokinetic modeling in predicting drug–drug interactions for sarpogrelate hydrochloride in humans

Min JS, Kim D, Park JB, Heo H, Bae SH, Seo JH, Oh E, Bae SK

Drug Design, Development and Therapy 2016, 10:2959-2972

Published Date: 14 September 2016

A triazole derivative elicits autophagic clearance of polyglutamine aggregation in neuronal cells

Hsieh CH, Lee LC, Leong WY, Yang TC, Yao CF, Fang K

Drug Design, Development and Therapy 2016, 10:2947-2957

Published Date: 14 September 2016

Effects of low-carbohydrate diet therapy in overweight subject with autoimmune thyroiditis: possible synergism with ChREBP

Esposito T, Lobaccaro JM, Esposito MG, Monda V, Messina A, Paolisso G, Varriale B, Monda M, Messina G

Drug Design, Development and Therapy 2016, 10:2939-2946

Published Date: 14 September 2016

Protein kinase C–mediated sodium glucose transporter 1 activation in precondition-induced cardioprotection

Kanwal A, Kasetti S, Putcha UK, Asthana S, Banerjee SK

Drug Design, Development and Therapy 2016, 10:2929-2938

Published Date: 14 September 2016

Effects of an immunosuppressive treatment on the rat prostate

Grabowska M, Kędzierska K, Michałek K, Słuczanowska-Głąbowska S, Grabowski M, Piasecka M, Kram A, Rotter I, Rył A, Laszczyńska M

Drug Design, Development and Therapy 2016, 10:2899-2915

Published Date: 12 September 2016

Understanding cytoskeleton regulators in glioblastoma multiforme for therapy design

Masoumi S, Harisankar A, Gracias A, Bachinger F, Fufa T, Chandrasekar G, Gaunitz F, Walfridsson J, Kitambi SS

Drug Design, Development and Therapy 2016, 10:2881-2897

Published Date: 12 September 2016

Synthesis, solubility, plasma stability, and pharmacological evaluation of novel sulfonylhydrazones designed as anti-diabetic agents

Zapata-Sudo G, da Costa Nunes IK, Araujo JSC, da Silva JS, Trachez MM, da Silva TF, da Costa FP, Sudo RT, Barreiro EJ, Lima LM

Drug Design, Development and Therapy 2016, 10:2869-2879

Published Date: 9 September 2016

In situ delivery of thermosensitive gel-mediated 5-fluorouracil microemulsion for the treatment of colorectal cancer

Wang LL, Huang S, Guo HH, Han YX, Zheng WS, Jiang JD

Drug Design, Development and Therapy 2016, 10:2855-2867

Published Date: 8 September 2016

Downregulation of DOCK1 sensitizes bladder cancer cells to cisplatin through preventing epithelial–mesenchymal transition

Chen D, Chen W, Jiang H, Yang H, Wang Y, Chen J

Drug Design, Development and Therapy 2016, 10:2845-2853

Published Date: 8 September 2016

Eltrombopag for the treatment of aplastic anemia: current perspectives

Lum SH, Grainger JD

Drug Design, Development and Therapy 2016, 10:2833-2843

Published Date: 13 September 2016

Development and in vitro characterization of poly(lactide-co-glycolide) microspheres loaded with an antibacterial natural drug for the treatment of long-term bacterial infections

Reinbold J, Hierlemann T, Hinkel H, Müller I, Maier ME, Weindl T, Schlensak C, Wendel HP, Krajewski S,

Drug Design, Development and Therapy 2016, 10:2823-2832

Published Date: 7 September 2016

Intranasal administration of elastin-like polypeptide for therapeutic delivery to the central nervous system

McGowan JWD, Shao Q, Vig PJS, Bidwell III GL

Drug Design, Development and Therapy 2016, 10:2803-2813

Published Date: 6 September 2016

The use of misoprostol for cervical priming prior to hysteroscopy: a systematic review and analysis

Hua Y, Zhang W, Hu X, Yang A, Zhu X

Drug Design, Development and Therapy 2016, 10:2789-2801

Published Date: 6 September 2016

Two Phase II randomized trials on the CRTh2 antagonist AZD1981 in adults with asthma

Kuna P, Bjermer L, Tornling G

Drug Design, Development and Therapy 2016, 10:2759-2770

Published Date: 31 August 2016

Anti-inflammatory drugs for Duchenne muscular dystrophy: focus on skeletal muscle-releasing factors

Miyatake S, Shimizu-Motohashi Y, Takeda S, Aoki Y

Drug Design, Development and Therapy 2016, 10:2745-2758

Published Date: 30 August 2016

Chloroquine improves left ventricle diastolic function in streptozotocin-induced diabetic mice

Yuan X, Xiao YC, Zhang GP, Hou N, Wu XQ, Chen WL, Luo JD, Zhang GS

Drug Design, Development and Therapy 2016, 10:2729-2737

Published Date: 30 August 2016

Clinical study in genital herpes: natural Gene-Eden-VIR/Novirin versus acyclovir, valacyclovir, and famciclovir

Polansky H, Javaherian A, Itzkovitz E

Drug Design, Development and Therapy 2016, 10:2713-2722

Published Date: 29 August 2016

Nanomedical strategy to prolong survival period, heighten cure rate, and lower systemic toxicity of S180 mice treated with MTX/MIT

Song N, Zhao M, Wang Y, Hu X, Wu J, Jiang X, Li S, Cui C, Peng S

Drug Design, Development and Therapy 2016, 10:2701-2711

Published Date: 30 August 2016

Ticagrelor promotes atherosclerotic plaque stability in a mouse model of advanced atherosclerosis

Preusch MR, Rusnak J, Staudacher K, Mogler C, Uhlmann L, Sievers P, Bea F, Katus HA, Blessing E, Staudacher I

Drug Design, Development and Therapy 2016, 10:2691-2699

Published Date: 26 August 2016

Design, synthesis, and characterization of (1-(4-aryl)-1H-1,2,3-triazol-4-yl)methyl, substituted phenyl-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylates against Mycobacterium tuberculosis

Venugopala KN, Dharma Rao GB, Bhandary S, Pillay M, Chopra D, Aldhubiab BE, Attimarad M, Alwassil OI, Harsha S, Mlisana K

Drug Design, Development and Therapy 2016, 10:2681-2690

Published Date: 25 August 2016

Development of betulinic acid as an agonist of TGR5 receptor using a new in vitro assay

Lo SH, Cheng KC, Li YX, Chang CH, Cheng JT, Lee KS

Drug Design, Development and Therapy 2016, 10:2669-2676

Published Date: 22 August 2016

Effects of alprostadil and iloprost on renal, lung, and skeletal muscle injury following hindlimb ischemia–reperfusion injury in rats

Erer D, Özer A, Demirtaş H, Gönül İI, Kara H, Arpacı H, Çomu FM, Oktar GL, Arslan M, Küçük A

Drug Design, Development and Therapy 2016, 10:2651-2658

Published Date: 19 August 2016

Pharmacokinetic profile of defibrotide in patients with renal impairment

Tocchetti P, Tudone E, Marier JF, Marbury TC, Zomorodi K, Eller M

Drug Design, Development and Therapy 2016, 10:2631-2641

Published Date: 16 August 2016

Novel glyoxalase-I inhibitors possessing a “zinc-binding feature” as potential anticancer agents

Al-Balas QA, Hassan MA, Al-Shar’i NA, Mhaidat NM, Almaaytah AM, Al-Mahasneh FM, Isawi IH

Drug Design, Development and Therapy 2016, 10:2623-2629

Published Date: 17 August 2016

Construction of p66Shc gene interfering lentivirus vectors and its affections on alveolar epithelial cells apoptosis induced by hyperoxia

Zhang C, Dong WB, Zhao S, Li QP, Kang L, Lei XP, Guo L, Zhai XS

Drug Design, Development and Therapy 2016, 10:2611-2622

Published Date: 16 August 2016

Design and characteristics of cytotoxic fibroblast growth factor 1 conjugate for fibroblast growth factor receptor-targeted cancer therapy

Szlachcic A, Zakrzewska M, Lobocki M, Jakimowicz P, Otlewski J

Drug Design, Development and Therapy 2016, 10:2547-2560

Published Date: 9 August 2016

Effects of salvianolate on bone metabolism in glucocorticoid-treated lupus-prone B6.MRL-Faslpr/J mice

Liu Y, Cui Y, Zhang X, Gao X, Su Y, Xu B, Wu T, Chen W, Cui L

Drug Design, Development and Therapy 2016, 10:2535-2546

Published Date: 9 August 2016

Pharmacokinetic and pharmacodynamic interactions between metformin and a novel dipeptidyl peptidase-4 inhibitor, evogliptin, in healthy subjects

Rhee SJ, Choi Y, Lee S, Oh J, Kim SJ, Yoon SH, Cho JY, Yu KS

Drug Design, Development and Therapy 2016, 10:2525-2534

Published Date: 10 August 2016

NAD(P)H:quinone oxidoreductase 1 inducer activity of some novel anilinoquinazoline derivatives

Ghorab MM, Alsaid MS, Higgins M, Dinkova-Kostova AT, Shahat AA, Elghazawy NH, Arafa RK

Drug Design, Development and Therapy 2016, 10:2515-2524

Published Date: 8 August 2016

Endoplasmic reticulum stress-induced autophagy determines the susceptibility of melanoma cells to dabrafenib

Ji C, Zhang ZP, Chen LH, Zhou KL, Li DJ, Wang P, Huang SY, Gong T, Cheng B

Drug Design, Development and Therapy 2016, 10:2491-2498

Published Date: 4 August 2016

Metformin increases pressure pain threshold in lean women with polycystic ovary syndrome

Kiałka M, Milewicz T, Sztefko K, Rogatko I, Majewska R

Drug Design, Development and Therapy 2016, 10:2483-2490

Published Date: 3 August 2016

Effects of lornoxicam and intravenous ibuprofen on erythrocyte deformability and hepatic and renal blood flow in rats

Arpacı H, Çomu FM, Küçük A, Kösem B, Kartal S, Şıvgın V, Turgut HC, Aydın ME, Koç DS, Arslan M

Drug Design, Development and Therapy 2016, 10:2477-2481

Published Date: 3 August 2016

Design of a nanostructured lipid carrier intended to improve the treatment of tuberculosis

Pinheiro M, Ribeiro R, Vieira A, Andrade F, Reis S

Drug Design, Development and Therapy 2016, 10:2467-2475

Published Date: 2 August 2016

Receptor tyrosine kinase (c-Kit) inhibitors: a potential therapeutic target in cancer cells

Abbaspour Babaei M, Kamalidehghan B, Saleem M, Huri HZ, Ahmadipour F

Drug Design, Development and Therapy 2016, 10:2443-2459

Published Date: 1 August 2016

The role of CD147 expression in prostate cancer: a systematic review and meta-analysis

Ye Y, Li SL, Wang Y, Yao Y, Wang J, Ma YY, Hao XK

Drug Design, Development and Therapy 2016, 10:2435-2442

Published Date: 1 August 2016

Flurbiprofen–antioxidant mutual prodrugs as safer nonsteroidal anti-inflammatory drugs: synthesis, pharmacological investigation, and computational molecular modeling

Ashraf Z, Alamgeer, Kanwal M, Hassan M, Abdullah S, Waheed M, Ahsan H, Kim SJ

Drug Design, Development and Therapy 2016, 10:2401-2419

Published Date: 27 July 2016

A review of omalizumab for the management of severe asthma

Lin CH, Cheng SL

Drug Design, Development and Therapy 2016, 10:2369-2378

Published Date: 26 July 2016

Distinct role of the Fas rs1800682 and FasL rs763110 polymorphisms in determining the risk of breast cancer among Han Chinese women

Wang M, Wang Z, Wang XJ, Jin TB, Dai ZM, Kang HF, Guan HT, Ma XB, Liu XH, Dai ZJ

Drug Design, Development and Therapy 2016, 10:2359-2367

Published Date: 25 July 2016

Paclitaxel plus valproic acid versus paclitaxel alone as second- or third-line therapy for advanced gastric cancer: a randomized Phase II trial

Fushida S, Kinoshita J, Kaji M, Oyama K, Hirono Y, Tsukada T, Fujimura T, Ohta T

Drug Design, Development and Therapy 2016, 10:2353-2358

Published Date: 25 July 2016

Novel A20-gene-eluting stent inhibits carotid artery restenosis in a porcine model

Zhou ZH, Peng J, Meng ZY, Chen L, Huang JL, Huang HQ, Li L, Zeng W, Wei Y, Zhu CH, Chen KN

Drug Design, Development and Therapy 2016, 10:2341-2351

Published Date: 8 August 2016

Voiding dysfunction in patients with nasal congestion treated with pseudoephedrine: a prospective study

Shao IH, Wu CC, Tseng HJ, Lee TJ, Lin YH, Tam YY

Drug Design, Development and Therapy 2016, 10:2333-2339

Published Date: 19 July 2016

Prediction of selective estrogen receptor beta agonist using open data and machine learning approach

Niu AQ, Xie LJ, Wang H, Zhu B, Wang SQ

Drug Design, Development and Therapy 2016, 10:2323-2331

Published Date: 18 July 2016

SPOCK1 promotes tumor growth and metastasis in human prostate cancer

Chen Q, Yao YT, Xu H, Chen YB, Gu M, Cai ZK, Wang Z

Drug Design, Development and Therapy 2016, 10:2311-2321

Published Date: 18 July 2016

Rational design and synthesis of novel diphenyl ether derivatives as antitubercular agents

Kar SS, Bhat G V, Rao PP, Shenoy VP, Bairy I, Shenoy GG

Drug Design, Development and Therapy 2016, 10:2299-2310

Published Date: 18 July 2016

Galeterone for the treatment of advanced prostate cancer: the evidence to date

Bastos DA, Antonarakis ES

Drug Design, Development and Therapy 2016, 10:2289-2297

Published Date: 15 July 2016

The influence of intrauterine exposure to immunosuppressive treatment on changes in the immune system in juvenile Wistar rats

Kabat-Koperska J, Kolasa-Wołosiuk A, Wojciuk B, Wojciechowska-Koszko I, Roszkowska P, Krasnodębska-Szponder B, Paczkowska E, Safranow K, Gołembiewska E, Machaliński B, Ciechanowski K

Drug Design, Development and Therapy 2016, 10:2279-2288

Published Date: 14 July 2016

Simvastatin attenuates radiation-induced salivary gland dysfunction in mice

Xu L, Yang X, Chen J, Ge X, Qin Q, Zhu H, Zhang C, Sun X

Drug Design, Development and Therapy 2016, 10:2271-2278

Published Date: 13 July 2016

Thymoquinone subdues tumor growth and potentiates the chemopreventive effect of 5-fluorouracil on the early stages of colorectal carcinogenesis in rats

Kensara OA, El-Shemi AG, Mohamed AM, Refaat B, Idris S, Ahmad J

Drug Design, Development and Therapy 2016, 10:2239-2253

Published Date: 11 July 2016

Pharmacogenetic analysis of cinacalcet response in secondary hyperparathyroidism patients

Jeong S, Kim IW, Oh KH, Han N, Joo KW, Kim HJ, Oh JM

Drug Design, Development and Therapy 2016, 10:2211-2225

Published Date: 8 July 2016

Acyl lipidation of a peptide: effects on activity and epidermal permeability in vitro

Rocco D, Ross J, Murray PE, Caccetta R

Drug Design, Development and Therapy 2016, 10:2203-2209

Published Date: 8 July 2016

Rosmarinic acid ameliorates hyperglycemia and insulin sensitivity in diabetic rats, potentially by modulating the expression of PEPCK and GLUT4

Runtuwene J, Cheng KC, Asakawa A, Amitani H, Amitani M, Morinaga A, Takimoto Y, Kairupan BHR, Inui A

Drug Design, Development and Therapy 2016, 10:2193-2202

Published Date: 7 July 2016

Effect of N-methyl deuteration on metabolism and pharmacokinetics of enzalutamide

Jiang J, Pang X, Li L, Dai X, Diao X, Chen X, Zhong D, Wang Y, Chen Y

Drug Design, Development and Therapy 2016, 10:2181-2191

Published Date: 7 July 2016

The effects of ferulic acid on the pharmacokinetics of warfarin in rats after biliary drainage

Li H, Wang Y, Fan R, Lv H, Sun H, Xie H, Tang T, Luo J, Xia Z

Drug Design, Development and Therapy 2016, 10:2173-2180

Published Date: 6 July 2016

Cabozantinib in the treatment of advanced renal cell carcinoma: design, development, and potential place in the therapy

Grassi P, Verzoni E, Ratta R, Mennitto A, de Braud F, Procopio G

Drug Design, Development and Therapy 2016, 10:2167-2172

Published Date: 5 July 2016

Real-time monitoring of cisplatin cytotoxicity on three-dimensional spheroid tumor cells

Baek NH, Seo OW, Lee J, Hulme J, An SSA

Drug Design, Development and Therapy 2016, 10:2155-2165

Published Date: 4 July 2016

Pharmacophore modeling and in silico toxicity assessment of potential anticancer agents from African medicinal plants

Ntie-Kang F, Simoben CV, Karaman B, Ngwa VF, Judson PN, Sippl W, Mbaze LM

Drug Design, Development and Therapy 2016, 10:2137-2154

Published Date: 4 July 2016

Clinical implications for substandard, nonproprietary medicines in multiple sclerosis: focus on fingolimod

Correale J, Chiquete E, Boyko A, Beran RG, Strauch JB, Milojevic S, Frider N

Drug Design, Development and Therapy 2016, 10:2109-2117

Published Date: 30 June 2016

Sitagliptin attenuates cardiomyopathy by modulating the JAK/STAT signaling pathway in experimental diabetic rats

Al-Rasheed NM, Al-Rasheed NM, Hasan IH, Al-Amin MA, Al-Ajmi HN, Mahmoud AM

Drug Design, Development and Therapy 2016, 10:2095-2107

Published Date: 28 June 2016

Golimumab in radiographic and nonradiographic axial spondyloarthritis: a review of clinical trials

Toussirot E, Vauchy C, Binda D, Michel F

Drug Design, Development and Therapy 2016, 10:2087-2094

Published Date: 1 July 2016

Dietary arginine silicate inositol complex increased bone healing: histologic and histomorphometric study

Yaman F, Acikan I, Dundar S, Simsek S, Gul M, Ozercan İH, Komorowski J, Sahin K

Drug Design, Development and Therapy 2016, 10:2081-2086

Published Date: 27 June 2016

Secukinumab for rheumatology: development and its potential place in therapy

Koenders MI, van den Berg WB

Drug Design, Development and Therapy 2016, 10:2069-2080

Published Date: 24 June 2016

The cytotoxicity study of praziquantel enantiomers

Sun Q, Mao RF, Wang DL, Hu CY, Zheng Y, Sun DQ

Drug Design, Development and Therapy 2016, 10:2061-2068

Published Date: 24 June 2016

Anti-dengue drug: viral polyprotein, a potential target

Mahmood SU, Mushtaq M, Syed MJ

Drug Design, Development and Therapy 2016, 10:2047-2048

Published Date: 24 June 2016

Fondaparinux vs warfarin for the treatment of unsuspected pulmonary embolism in cancer patients

Amato B, Compagna R, Rocca A, Bianco T, Milone M, Sivero L, Vigliotti G, Amato M, Danzi M, Aprea G, Gallelli L, de Franciscis S, Serra R

Drug Design, Development and Therapy 2016, 10:2041-2046

Published Date: 23 June 2016

A novel pH–enzyme-dependent mesalamine colon-specific delivery system

Jin L, Ding Y, Zhang Y, Xu X, Cao Q

Drug Design, Development and Therapy 2016, 10:2021-2028

Published Date: 20 June 2016

MART-10, a newly synthesized vitamin D analog, represses metastatic potential of head and neck squamous carcinoma cells

Yang SW, Tsai CY, Pan YC, Yeh CN, Pang JHS, Takano M, Kittaka A, Juang HH, Chen TC, Chiang KC

Drug Design, Development and Therapy 2016, 10:1995-2002

Published Date: 17 June 2016

Double-blind, randomized, double-dummy clinical trial comparing the efficacy of ketorolac trometamol and naproxen for acute low back pain

Plapler PG, Scheinberg MA, Ecclissato CC, Bocchi de Oliveira MF, Amazonas RB

Drug Design, Development and Therapy 2016, 10:1987-1993

Published Date: 17 June 2016

Prophylactic effects of Clausena excavata Burum. f. leaf extract in ethanol-induced gastric ulcers

Albaayit SFA, Abba Y, Abdullah R, Abdullah N

Drug Design, Development and Therapy 2016, 10:1973-1986

Published Date: 15 June 2016

Efficacy and safety of gemcitabine plus erlotinib for locally advanced or metastatic pancreatic cancer: a systematic review and meta-analysis

Wang Y, Hu GF, Zhang QQ, Tang N, Guo J, Liu LY, Han X, Wang X, Wang ZH

Drug Design, Development and Therapy 2016, 10:1961-1972

Published Date: 13 June 2016

A novel imidazopyridine derivative, X22, attenuates sepsis-induced lung and liver injury by inhibiting the inflammatory response in vitro and in vivo

Ge X, Feng Z, Xu T, Wu B, Chen H, Xu F, Fu L, Shan X, Dai Y, Zhang Y, Liang G

Drug Design, Development and Therapy 2016, 10:1947-1959

Published Date: 24 June 2016

The efficacy of nebulized magnesium sulfate alone and in combination with salbutamol in acute asthma

Sarhan HA, EL-Garhy OH, Ali MA, Youssef NA

Drug Design, Development and Therapy 2016, 10:1927-1933

Published Date: 9 June 2016

In vivo gastric residence and gastroprotective effect of floating gastroretentive tablet of DA-9601, an extract of Artemisia asiatica, in beagle dogs

Kim JS, Cha KH, Kang SY, Won D, Jang SW, Son M, Son MH, Choi HJ, Lee YW, Kang MJ

Drug Design, Development and Therapy 2016, 10:1917-1925

Published Date: 9 June 2016

Role of cytochrome P450 2D6 genetic polymorphism in carvedilol hydroxylation in vitro

Wang Z, Wang L, Xu RA, Zhan YY, Huang CK, Dai DP, Cai JP, Hu GX

Drug Design, Development and Therapy 2016, 10:1909-1916

Published Date: 8 June 2016

Flavokawain derivative FLS induced G2/M arrest and apoptosis on breast cancer MCF-7 cell line

Ali NM, Akhtar MN, Ky H, Lim KL, Abu N, Zareen S, Ho WY, Alan-Ong HK, Tan SW, Alitheen NB, Ismail JB, Yeap SK, Kamarul T

Drug Design, Development and Therapy 2016, 10:1897-1907

Published Date: 10 June 2016

Molecular mechanisms of cisplatin resistance in cervical cancer

Zhu H, Luo H, Zhang W, Shen Z, Hu X, Zhu X

Drug Design, Development and Therapy 2016, 10:1885-1895

Published Date: 7 June 2016

Erythropoietin ameliorates hyperglycemia in type 1-like diabetic rats

Niu HS, Chang CH, Niu CS, Cheng JT, Lee KS

Drug Design, Development and Therapy 2016, 10:1877-1884

Published Date: 3 June 2016

Indigofera oblongifolia mitigates lead-acetate-induced kidney damage and apoptosis in a rat model

Dkhil MA, Al-Khalifa MS, Al-Quraishy S, Zrieq R, Abdel Moneim AE

Drug Design, Development and Therapy 2016, 10:1847-1856

Published Date: 2 June 2016

Nelfinavir is effective against human cervical cancer cells in vivo: a potential treatment modality in resource-limited settings

Davis MA, Delaney JR, Patel CB, Storgard R, Stupack DG

Drug Design, Development and Therapy 2016, 10:1837-1846

Published Date: 2 June 2016

Synthesis, activity, and docking study of phenylthiazole acids as potential agonists of PPARγ

Ma L, Wang T, Shi M, Ye H

Drug Design, Development and Therapy 2016, 10:1807-1815

Published Date: 30 May 2016

The arsenal of pathogens and antivirulence therapeutic strategies for disarming them

Brannon JR, Hadjifrangiskou M

Drug Design, Development and Therapy 2016, 10:1795-1806

Published Date: 27 May 2016

An open-label clinical trial of agalsidase alfa enzyme replacement therapy in children with Fabry disease who are naïve to enzyme replacement therapy

Goker-Alpan O, Longo N, McDonald M, Shankar SP, Schiffmann R, Chang P, Shen Y, Pano A

Drug Design, Development and Therapy 2016, 10:1771-1781

Published Date: 25 May 2016

Apremilast in the therapy of moderate-to-severe chronic plaque psoriasis

Gisondi P, Girolomoni G

Drug Design, Development and Therapy 2016, 10:1763-1770

Published Date: 25 May 2016

Activity of a novel sulfonamide compound 2-nitro-N-(pyridin-2-ylmethyl)benzenesulfonamide against Leishmania donovani

Dikhit MR, Purkait B, Singh R, Sahoo BR, Kumar A, Kar RK, Ansari MY, Saini S, Abhishek K, Sahoo GC, Das S, Das P

Drug Design, Development and Therapy 2016, 10:1753-1761

Published Date: 26 May 2016

Computer-aided vaccine designing approach against fish pathogens Edwardsiella tarda and Flavobacterium columnare using bioinformatics softwares

Mahendran R, Jeyabaskar S, Sitharaman G, Michael RD, Paul AV

Drug Design, Development and Therapy 2016, 10:1703-1714

Published Date: 23 May 2016

Electroporation-delivered transdermal neostigmine in rats: equivalent action to intravenous administration

Berkó S, Szűcs KF, Balázs B, Csányi E, Varju G, Sztojkov-Ivanov A, Budai-Szűcs M, Bóta J, Gáspár R

Drug Design, Development and Therapy 2016, 10:1695-1701

Published Date: 19 May 2016

Safety, tolerability, pharmacokinetics, and pharmacodynamics of novel glucokinase activator HMS5552: results from a first-in-human single ascending dose study

Xu HR, Sheng L, Chen WL, Yuan F, Yang MJ, Li H, Li XN, Choi J, Zhao GY, Hu TX, Li YG, Zhang Y, Chen L

Drug Design, Development and Therapy 2016, 10:1619-1626

Published Date: 9 May 2016

Effectiveness, durability, and safety of darunavir/ritonavir in HIV-1-infected patients in routine clinical practice in Italy: a postauthorization noninterventional study

Antinori A, Meraviglia P, d’Arminio Monforte A, Castagna A, Mussini C, Bini T, Gianotti N, Rusconi S, Colella E, Airoldi G, Mancusi D, Termini R

Drug Design, Development and Therapy 2016, 10:1589-1603

Published Date: 6 May 2016

Fimasartan for independent reduction of blood pressure variability in mild-to-moderate hypertension

Shin MS, Kang DR, Kim C, Cho EJ, Sung KC, Kang SM, Kim DS, Joo SJ, Lee SH, Hwang KK, Park JB

Drug Design, Development and Therapy 2016, 10:1573-1580

Published Date: 5 May 2016

Fungistatic activity of all-trans retinoic acid against Aspergillus fumigatus and Candida albicans

Campione E, Gaziano R, Marino D, Orlandi A

Drug Design, Development and Therapy 2016, 10:1551-1555

Published Date: 29 April 2016

Zolav®: a new antibiotic for the treatment of acne [Corrigendum]

Dinant A, Boulos RA

Drug Design, Development and Therapy 2016, 10:1549-1550

Published Date: 29 April 2016

Efficacy and safety of different doses of a slow-release corticosteroid implant for macular edema [Corrigendum]

Liu QY, He MM, Shi H, Wang QY, Du YR, Liu JL, Ren CD, Xu D, Yu J

Drug Design, Development and Therapy 2016, 10:1547-1548

Published Date: 27 April 2016

The influence of dietary sodium content on the pharmacokinetics and pharmacodynamics of fimasartan

Gu N, Cho JY, Shin KH, Jang IJ, Rhee MY

Drug Design, Development and Therapy 2016, 10:1525-1531

Published Date: 19 April 2016

Autophagy inhibition enhances RAD001-induced cytotoxicity in human bladder cancer cells

Lin JF, Lin YC, Yang SC, Tsai TF, Chen HE, Chou KY, Hwang TIS

Drug Design, Development and Therapy 2016, 10:1501-1513

Published Date: 18 April 2016

Design, synthesis, and biological evaluation of 3-vinyl-quinoxalin-2(1H)-one derivatives as novel antitumor inhibitors of FGFR1

Liu Z, Yu S, Chen D, Shen G, Wang Y, Hou L, Lin D, Zhang JS, Ye F

Drug Design, Development and Therapy 2016, 10:1489-1500

Published Date: 3 May 2016

Neuroprotective effect of β-asarone against Alzheimer’s disease: regulation of synaptic plasticity by increased expression of SYP and GluR1

Liu SJ, Yang C, Zhang Y, Su RY, Chen JL, Jiao MM, Chen HF, Zheng N, Luo S, Chen YB, Quan SJ, Wang Q

Drug Design, Development and Therapy 2016, 10:1461-1469

Published Date: 15 April 2016

Zoledronate upregulates MMP-9 and -13 in rat vascular smooth muscle cells by inducing oxidative stress

Arun MZ, Reel B, Sala-Newby GB, Bond M, Tsaousi A, Maskell P, Newby AC

Drug Design, Development and Therapy 2016, 10:1453-1460

Published Date: 18 April 2016

Xyloketal-derived small molecules show protective effect by decreasing mutant Huntingtin protein aggregates in Caenorhabditis elegans model of Huntington’s disease

Zeng YX, Guo WY, Xu GQ, Wang QM, Feng LY, Long SM, Liang FY, Huang Y, Lu XL, Li SC, Zhou JB, Burgunder JM, Pang JY, Pei Z

Drug Design, Development and Therapy 2016, 10:1443-1451

Published Date: 13 April 2016

Baicalein suppresses metastasis of breast cancer cells by inhibiting EMT via downregulation of SATB1 and Wnt/β-catenin pathway

Ma X, Yan W, Dai Z, Gao X, Ma Y, Xu Q, Jiang J, Zhang S

Drug Design, Development and Therapy 2016, 10:1419-1441

Published Date: 18 April 2016

Functionalized D-form self-assembling peptide hydrogels for bone regeneration

He B, Ou Y, Zhou A, Chen S, Zhao W, Zhao J, Li H, Zhu Y, Zhao Z, Jiang D

Drug Design, Development and Therapy 2016, 10:1379-1388

Published Date: 11 April 2016

Neuroprotective effects of salidroside through PI3K/Akt pathway activation in Alzheimer’s disease models

Zhang B, Wang Y, Li H, Xiong R, Zhao Z, Chu X, Li Q, Sun S, Chen S

Drug Design, Development and Therapy 2016, 10:1335-1343

Published Date: 6 April 2016

Identification of new drug candidates against Borrelia burgdorferi using high-throughput screening

Pothineni VR, Wagh D, Babar MM, Inayathullah M, Solow-Cordero DE, Kim KM, Samineni AV, Parekh MB, Tayebi L, Rajadas J

Drug Design, Development and Therapy 2016, 10:1307-1322

Published Date: 1 April 2016

In vitro and in vivo efficacy of afatinib as a single agent or in combination with gemcitabine for the treatment of nasopharyngeal carcinoma

Xue C, Tian Y, Zhang J, Zhao YY, Zhan JH, Fang WF, Zhang L

Drug Design, Development and Therapy 2016, 10:1299-1306

Published Date: 31 March 2016

Curcumin protects against myocardial infarction-induced cardiac fibrosis via SIRT1 activation in vivo and in vitro

Xiao J, Sheng X, Zhang X, Guo M, Ji X

Drug Design, Development and Therapy 2016, 10:1267-1277

Published Date: 29 March 2016

Comparative efficacy of tamsulosin versus nifedipine for distal ureteral calculi: a meta-analysis

Wang H, Man LB, Huang GL, Li GZ, Wang JW

Drug Design, Development and Therapy 2016, 10:1257-1265

Published Date: 29 March 2016

Zolav®: a new antibiotic for the treatment of acne

Dinant A, Boulos RA

Drug Design, Development and Therapy 2016, 10:1235-1242

Published Date: 22 March 2016

The renoprotective effects of sulodexide

Olde Engberink RH, Vogt L

Drug Design, Development and Therapy 2016, 10:1233-1234

Published Date: 22 March 2016

Role of glycogen synthase kinase-3β inhibitor AZD1080 in ovarian cancer

Chen S, Sun KX, Feng MX, Sang XB, Liu BL, Zhao Y

Drug Design, Development and Therapy 2016, 10:1225-1232

Published Date: 18 March 2016

Effects of acute and chronic administration of neurosteroid dehydroepiandrosterone sulfate on neuronal excitability in mice

Svob Strac D, Vlainic J, Samardzic J, Erhardt J, Krsnik Z

Drug Design, Development and Therapy 2016, 10:1201-1215

Published Date: 21 March 2016

Computational and nonglycosylated systems: a simpler approach for development of nanosized PEGylated proteins

Mirzaei H, Kazemi B, Bandehpour M, Shoari A, Asgary V, Ardestani MS, Madadkar-Sobhani A, Ahangari Cohan R

Drug Design, Development and Therapy 2016, 10:1193-1200

Published Date: 16 March 2016

Sonodynamic effect of hematoporphyrin monomethyl ether on ligature-induced periodontitis in rats [Corrigendum]

Zhuang DS, Han JL, Bi LJ, Wang YP, Hao YR, Zhou Q, Cao WW

Drug Design, Development and Therapy 2016, 10:1191-1192

Published Date: 17 March 2016

Efficacy of BIBF 1120 or BIBF 1120 plus chemotherapy on nasopharyngeal carcinoma in vitro and in vivo

Xue C, Tian Y, Zhang J, Zhao Y, Zhan J, Fang W, Zhang L

Drug Design, Development and Therapy 2016, 10:1173-1180

Published Date: 15 March 2016

Toward antituberculosis drugs: in silico screening of synthetic compounds against Mycobacterium tuberculosis L,D-transpeptidase 2

Billones JB, Carrillo MCO, Organo VG, Macalino SJY, Sy JBA, Emnacen IA, Clavio NAB, Concepcion GP

Drug Design, Development and Therapy 2016, 10:1147-1157

Published Date: 11 March 2016

Synthesis, antimicrobial, and antiproliferative activities of substituted phenylfuranylnicotinamidines

Youssef MM, Arafa RK, Ismail MA,

Drug Design, Development and Therapy 2016, 10:1133-1146

Published Date: 11 March 2016

Selective use of sorafenib in the treatment of thyroid cancer

Pitoia F, Jerkovich F

Drug Design, Development and Therapy 2016, 10:1119-1131

Published Date: 11 March 2016

Formulation and clinical evaluation of silymarin pluronic-lecithin organogels for treatment of atopic dermatitis

Mady FM, Essa H, El-Ammawi T, Abdelkader H, Hussein AK

Drug Design, Development and Therapy 2016, 10:1101-1110

Published Date: 10 March 2016

Protective effects of honokiol on ischemia/reperfusion injury of rat ovary: an experimental study

Yaman Tunc S, Agacayak E, Goruk NY, Icen MS, Turgut A, Alabalik U, Togrul C, Ekinci C, Ekinci A, Gul T

Drug Design, Development and Therapy 2016, 10:1077-1083

Published Date: 8 March 2016

RGD(F/S/V)-Dex: towards the development of novel, effective, and safe glucocorticoids

Jiang X, Zhao M, Wang Y, Zhu H, Zhao S, Wu J, Song Y, Peng S

Drug Design, Development and Therapy 2016, 10:1059-1076

Published Date: 8 March 2016

Chloroquine enhances the efficacy of cisplatin by suppressing autophagy in human adrenocortical carcinoma treatment

Qin L, Xu TY, Xia LL, Wang XJ, Zhang X, Zhang XH, Zhu ZW, Zhong S, Wang CD, Shen ZJ

Drug Design, Development and Therapy 2016, 10:1035-1045

Published Date: 7 March 2016

Stability studies of lincomycin hydrochloride in aqueous solution and intravenous infusion fluids

Czarniak P, Boddy M, Sunderland B, Hughes JD

Drug Design, Development and Therapy 2016, 10:1029-1034

Published Date: 7 March 2016

Amsacrine analog-loaded solid lipid nanoparticle to resolve insolubility for injection delivery: characterization and pharmacokinetics

Fang YP, Chuang CH, Wu PC, Huang YB, Tzeng CC, Chen YL, Liu YT, Tsai YH, Tsai MJ

Drug Design, Development and Therapy 2016, 10:1019-1028

Published Date: 4 March 2016

Plasmodium-infected erythrocytes (pRBC) induce endothelial cell apoptosis via a heme-mediated signaling pathway

Liu M, Dickinson-Copeland C, Hassana S, Stiles JK

Drug Design, Development and Therapy 2016, 10:1009-1018

Published Date: 3 March 2016

Da0324, an inhibitor of nuclear factor-κB activation, demonstrates selective antitumor activity on human gastric cancer cells

Jin R, Xia Y, Chen Q, Li W, Chen D, Ye H, Zhao C, Du X, Shi D, Wu J, Liang G

Drug Design, Development and Therapy 2016, 10:979-995

Published Date: 2 March 2016

Eucommia bark (Du-Zhong) improves diabetic nephropathy without altering blood glucose in type 1-like diabetic rats

Niu HS, Liu IM, Niu CS, Ku PM, Hsu CT, Cheng JT

Drug Design, Development and Therapy 2016, 10:971-978

Published Date: 2 March 2016

Solubility enhancement of simvastatin by arginine: thermodynamics, solute–solvent interactions, and spectral analysis

Meor Mohd Affandi MMR, Tripathy M, Shah SAA, Majeed ABA

Drug Design, Development and Therapy 2016, 10:959-969

Published Date: 2 March 2016

Effects of Dang-Gui-Bu-Xue-Tang, an herbal decoction, on iron uptake in iron-deficient anemia

Huang GC, Chen SY, Tsai PW, Ganzon JG, Lee CJ, Shiah HS, Wang CC

Drug Design, Development and Therapy 2016, 10:949-957

Published Date: 2 March 2016

Effect of picroside II on erythrocyte deformability and lipid peroxidation in rats subjected to hind limb ischemia reperfusion injury

Çomu FM, Kılıç Y, Özer A, Kirişçi M, Dursun AD, Tatar T, Zor MH, Kartal H, Küçük A, Boyunağa H, Arslan M

Drug Design, Development and Therapy 2016, 10:927-931

Published Date: 1 March 2016

Naringenin-loaded solid lipid nanoparticles: preparation, controlled delivery, cellular uptake, and pulmonary pharmacokinetics

Ji P, Yu T, Liu Y, Jiang J, Xu J, Zhao Y, Hao Y, Qiu Y, Zhao W, Wu C

Drug Design, Development and Therapy 2016, 10:911-925

Published Date: 1 March 2016

The aqueous extract of Glycyrrhiza inflata can upregulate unfolded protein response-mediated chaperones to reduce tau misfolding in cell models of Alzheimer’s disease

Chang KH, Chen IC, Lin HY, Chen HC, Lin CH, Lin TH, Weng YT, Chao CY, Wu YR, Lin JY, Lee-Chen GJ, Chen CM

Drug Design, Development and Therapy 2016, 10:885-896

Published Date: 29 February 2016

Spotlight on lenvatinib in the treatment of thyroid cancer: patient selection and perspectives

Costa R, Carneiro BA, Chandra S, Pai SG, Chae YK, Kaplan JB, Garrett HB, Agulnik M, Kopp PA, Giles FJ

Drug Design, Development and Therapy 2016, 10:873-884

Published Date: 29 February 2016

The interplay of post-translational modification and gene therapy

Osamor VC, Chinedu SN, Azuh DE, Iweala EJ, Ogunlana OO

Drug Design, Development and Therapy 2016, 10:861-871

Published Date: 29 February 2016

Papaverine inhibits lipopolysaccharide-induced microglial activation by suppressing NF-κB signaling pathway

Dang Y, Mu Y, Wang K, Xu K, Yang J, Zhu Y, Luo B

Drug Design, Development and Therapy 2016, 10:851-859

Published Date: 26 February 2016

The mechanism underlying alpinetin-mediated alleviation of pancreatitis-associated lung injury through upregulating aquaporin-1

Liang XS, Zhang B, Chen Q, Zhang J, Lei B, Li B, Wei YC, Zhai R, Liang ZQ, He SQ, Tang B

Drug Design, Development and Therapy 2016, 10:841-850

Published Date: 24 February 2016

Total saponin of Dioscoreae hypoglaucae rhizoma ameliorates streptozotocin-induced diabetic nephropathy

Guo C, Ding G, Huang W, Wang Z, Meng Z, Xiao W

Drug Design, Development and Therapy 2016, 10:799-810

Published Date: 24 February 2016

Synergistic roles of p53 and HIF1α in human renal cell carcinoma-cell apoptosis responding to the inhibition of mTOR and MDM2 signaling pathways

Liu QJ, Shen HL, Lin J, Xu XH, Ji ZG, Han X, Shang DH, Yang PQ

Drug Design, Development and Therapy 2016, 10:745-755

Published Date: 18 February 2016

A network pharmacology approach to discover active compounds and action mechanisms of San-Cao Granule for treatment of liver fibrosis

Wei S, Niu M, Wang J, Wang J, Su H, Luo S, Zhang X, Guo Y, Liu L, Liu F, Zhao Q, Chen H, Xiao X, Zhao P, Zhao Y

Drug Design, Development and Therapy 2016, 10:733-743

Published Date: 19 February 2016

Treatment with a Ginkgo biloba extract, EGb 761, inhibits excitotoxicity in an animal model of spinocerebellar ataxia type 17

Huang DS, Lin HY, Lee-Chen GJ, Hsieh-Li HM, Wu CH, Lin JY

Drug Design, Development and Therapy 2016, 10:723-731

Published Date: 18 February 2016

Effects of 22 novel CYP2D6 variants found in Chinese population on the metabolism of dapoxetine

Xu RA, Gu EM, Zhou Q, Yuan LJ, Hu XX, Cai JP, Hu GX

Drug Design, Development and Therapy 2016, 10:687-696

Published Date: 15 February 2016

Long-term use of amiodarone before heart transplantation significantly reduces early post-transplant atrial fibrillation and is not associated with increased mortality after heart transplantation

Rivinius R, Helmschrott M, Ruhparwar A, Schmack B, Erbel C, Gleissner CA, Akhavanpoor M, Frankenstein L, Darche FF, Schweizer PA, Thomas D, Ehlermann P, Bruckner T, Katus HA, Doesch AO

Drug Design, Development and Therapy 2016, 10:677-686

Published Date: 16 February 2016

Drug-loaded erythrocytes: on the road toward marketing approval

Bourgeaux V, Lanao JM, Bax BE, Godfrin Y

Drug Design, Development and Therapy 2016, 10:665-676

Published Date: 11 February 2016

Therapeutic effects of tyroservatide on metastasis of lung cancer and its mechanism affecting integrin–focal adhesion kinase signal transduction

Huang YT, Zhao L, Fu Z, Zhao M, Song XM, Jia J, Wang S, Li JP, Zhu ZF, Lin G, Lu R, Yao Z

Drug Design, Development and Therapy 2016, 10:649-663

Published Date: 3 March 2016

Epigallocatechin-3-gallate attenuates apoptosis and autophagy in concanavalin A-induced hepatitis by inhibiting BNIP3

Li S, Xia Y, Chen K, Li J, Liu T, Wang F, Lu J, Zhou Y, Guo C

Drug Design, Development and Therapy 2016, 10:631-647

Published Date: 15 February 2016

Protective effect of fucoidan from Fucus vesiculosus on liver fibrosis via the TGF-β1/Smad pathway-mediated inhibition of extracellular matrix and autophagy

Li J, Chen K, Li S, Feng J, Liu T, Wang F, Zhang R, Xu S, Zhou Y, Zhou S, Xia Y, Lu J, Zhou Y, Guo C

Drug Design, Development and Therapy 2016, 10:619-630

Published Date: 12 February 2016

Randomized clinical trial: pharmacokinetics and safety of multimatrix mesalamine for treatment of pediatric ulcerative colitis

Cuffari C, Pierce D, Korczowski B, Fyderek K, Van Heusen H, Hossack S, Wan H, Edwards AY, Martin P

Drug Design, Development and Therapy 2016, 10:593-607

Published Date: 4 February 2016

Establishment of a novel therapeutic vector targeting the trigeminal ganglion in rats

Xu K, Pan SY, Song JX, ,Liu XN, An N, Zheng X

Drug Design, Development and Therapy 2016, 10:585-592

Published Date: 4 February 2016

miR-125b acts as a tumor suppressor in chondrosarcoma cells by the sensitization to doxorubicin through direct targeting the ErbB2-regulated glucose metabolism

Tang XY, Zheng W, Ding M, Guo KJ, Yuan F, Feng H, Deng B, Sun W, Hou Y, Gao L

Drug Design, Development and Therapy 2016, 10:571-583

Published Date: 24 February 2016

Curcumin enhances the cytogenotoxic effect of etoposide in leukemia cells through induction of reactive oxygen species

Papież MA, Krzyściak W, Szade K, Bukowska-Straková K, Kozakowska M, Hajduk K, Bystrowska B, Dulak J, Jozkowicz A

Drug Design, Development and Therapy 2016, 10:557-570

Published Date: 4 February 2016

Targeting the D1-N-methyl-D-aspartate receptor complex reduces L-dopa-induced dyskinesia in 6-hydroxydopamine-lesioned Parkinson’s rats

Song L, Zhang ZZ, Hu RG, Cheng J, Li L, Fan QY, Wu N, Gan J, Zhou MZ, Liu ZG

Drug Design, Development and Therapy 2016, 10:547-555

Published Date: 3 February 2016

Antiviral therapy: a perspective

Shahidi Bonjar AH

Drug Design, Development and Therapy 2016, 10:541-546

Published Date: 2 February 2016

Preparation and characterization of silymarin synchronized-release microporous osmotic pump tablets

Zeng QP, Liu ZH, Huang AW, Zhang J, Song HT

Drug Design, Development and Therapy 2016, 10:519-531

Published Date: 29 January 2016

Determination of the binding mode for anti-inflammatory natural product xanthohumol with myeloid differentiation protein 2

Fu W, Chen L, Wang Z, Zhao C, Chen G, Liu X, Dai Y, Cai Y, Li C, Zhou J, Liang G

Drug Design, Development and Therapy 2016, 10:455-463

Published Date: 27 January 2016

Amelioration of concanavalin A-induced autoimmune hepatitis by magnesium isoglycyrrhizinate through inhibition of CD4+CD25-CD69+ subset proliferation

Yang Q, Wang J, Liu R, Wang Z, Li Y, Zhang Y, Hao X, Huang Y, Xie W, Wei H

Drug Design, Development and Therapy 2016, 10:443-453

Published Date: 25 January 2016

Efficacy of trabectedin in advanced soft tissue sarcoma: beyond lipo- and leiomyosarcoma [Corrigendum]

De Sanctis R, Marrari A, Marchetti S, Mussi C, Balzarini L, Lutman FR, Daolio P, Bastoni S, Bertuzzi AF, Quagliuolo V, Santoro A

Drug Design, Development and Therapy 2016, 10:441-442

Published Date: 28 January 2016

In vitro stress effect on degradation and drug release behaviors of basic fibroblast growth factor – poly(lactic-co-glycolic-acid) microsphere

Xiong Y, Yu ZP, Lang Y, Hu JY, Li H, Yan YG, Tu CQ, Yang TF, Song YM, Duan H, Pei FX

Drug Design, Development and Therapy 2016, 10:431-440

Published Date: 25 January 2016

Formulation, optimization, and pharmacodynamic evaluation of chitosan/phospholipid/β-cyclodextrin microspheres

Shan L, Tao EX, Meng QH, Hou WX, Liu K, Shang HC, Tang JB, Zhang WF

Drug Design, Development and Therapy 2016, 10:417-429

Published Date: 25 January 2016

Depot injectable atorvastatin biodegradable in situ gel: development, optimization, in vitro, and in vivo evaluation

Ahmed TA, Alharby YA, El-Helw AM, Hosny KM, El-Say KM

Drug Design, Development and Therapy 2016, 10:405-415

Published Date: 20 January 2016

High-dose OxyContin to treat pain associated with bone metastasis in patients with small-cell lung cancer: a case study report

Zhou T, Zhang X, Dong Y, Zhuang FF, Jiang FQ, Yu JM, Zhang B

Drug Design, Development and Therapy 2016, 10:383-387

Published Date: 19 January 2016

Effects of probenecid and cimetidine on the pharmacokinetics of nemonoxacin in healthy Chinese volunteers

Zhang YF, Dai XJ, Yang Y, Chen XY, Wang T, Tang YB, Tsai CY, Chang LW, Chang YT, Zhong DF

Drug Design, Development and Therapy 2016, 10:357-370

Published Date: 20 January 2016

Clinical pharmacology study of cariprazine (MP-214) in patients with schizophrenia (12-week treatment)

Nakamura T, Kubota T, Iwakaji A, Imada M, Kapás M, Morio Y

Drug Design, Development and Therapy 2016, 10:327-338

Published Date: 14 January 2016

Evidence of the gastroprotective and anti-Helicobacter pylori activities of β-mangostin isolated from Cratoxylum arborescens (vahl) blume

Sidahmed HMA, Hashim NM, Mohan S, Abdelwahab SI, Taha MME, Dehghan F, Yahayu M, Ee GCL, Loke MF, Vadivelu J

Drug Design, Development and Therapy 2016, 10:297-313

Published Date: 13 January 2016

Liposomal flucytosine capped with gold nanoparticle formulations for improved ocular delivery

Salem HF, Ahmed SM, Omar MM

Drug Design, Development and Therapy 2016, 10:277-295

Published Date: 13 January 2016

Quetiapine monotherapy in acute treatment of generalized anxiety disorder: a systematic review and meta-analysis of randomized controlled trials

Maneeton N, Maneeton B, Woottiluk P, Likhitsathian S, Suttajit S, Boonyanaruthee V, Srisurapanont M

Drug Design, Development and Therapy 2016, 10:259-276

Published Date: 12 January 2016

A clinical prognostic scoring system for resectable gastric cancer to predict survival and benefit from paclitaxel- or oxaliplatin-based adjuvant chemotherapy

Qian J, Qian Y, Wang J, Gu B, Pei D, He S, Zhu F, Røe OD, Xu J, Liu L, Gu Y, Guo R, Yin Y, Shu Y, Chen X

Drug Design, Development and Therapy 2016, 10:241-258

Published Date: 24 February 2016

Pasireotide: a novel treatment for patients with acromegaly

Cuevas-Ramos D, Fleseriu M

Drug Design, Development and Therapy 2016, 10:227-239

Published Date: 11 January 2016

Spotlight on ixazomib: potential in the treatment of multiple myeloma

Muz B, Ghazarian RN, Ou M, Luderer MJ, Kusdono HD, Azab AK

Drug Design, Development and Therapy 2016, 10:217-226

Published Date: 11 January 2016

Preparation, characterization, and in vivo evaluation of intranasally administered liposomal formulation of donepezil

Al Asmari AK, Ullah Z, Tariq M, Fatani A

Drug Design, Development and Therapy 2016, 10:205-215

Published Date: 12 January 2016

Design and evaluation of novel interferon lambda analogs with enhanced antiviral activity and improved drug attributes

Yu D, Zhao M, Dong L, Zhao L, Zou M, Sun H, Zhang M, Liu H, Zou Z

Drug Design, Development and Therapy 2016, 10:163-182

Published Date: 6 January 2016

Isolation and evaluation of biological efficacy of quercetol in human hepatic carcinoma cells

Ali H, Dixit S, Ali D, Alkahtane AA, Alarifi S, Ali BA, Alkahtani S

Drug Design, Development and Therapy 2016, 10:155-162

Published Date: 6 January 2016

Self-emulsifying drug delivery systems as a tool to improve solubility and bioavailability of resveratrol

Balata GF, Essa EA, Shamardl HA, Zaidan SH, Abourehab MAS

Drug Design, Development and Therapy 2016, 10:117-128

Published Date: 5 January 2016

The gastroprotective effects of hydroalcoholic extract of Monolluma quadrangula against ethanol-induced gastric mucosal injuries in Sprague Dawley rats

Ibrahim IAA, Abdulla MA, Hajrezaie M, Bader A, Shahzad N, Al-Ghamdi SS, Gushash AS, Hasanpourghadi M

Drug Design, Development and Therapy 2016, 10:93-105

Published Date: 30 December 2015

Promoting effect of small molecules in cardiomyogenic and neurogenic differentiation of rat bone marrow-derived mesenchymal stem cells

Khanabdali R, Saadat A, Fazilah M, Bazli KFK, Qazi RM, Khalid RS, Hasan Adli DS, Moghadamtousi SZ, Naeem N, Khan I, Salim A, Shamsuddin SAA, Mohan G

Drug Design, Development and Therapy 2016, 10:81-91

Published Date: 24 December 2015

MicroRNA-125a-5p modulates human cervical carcinoma proliferation and migration by targeting ABL2

Qin X, Wan Y, Wang S, Xue M

Drug Design, Development and Therapy 2016, 10:71-79

Published Date: 24 December 2015

BCc1, the novel antineoplastic nanocomplex, showed potent anticancer effects in vitro and in vivo

Kalanaky S, Hafizi M, Fakharzadeh S, Vasei M, Langroudi L, Janzamin E, Hashemi SM, Khayamzadeh M, Soleimani M, Akbari ME, Nazaran MH

Drug Design, Development and Therapy 2016, 10:59-70

Published Date: 30 December 2015

MEK inhibitors and their potential in the treatment of advanced melanoma: the advantages of combination therapy

Tran KA, Cheng MY, Mitra A, Ogawa H, Shi VY, Olney LP, Kloxin AM, Maverakis E

Drug Design, Development and Therapy 2016, 10:43-52

Published Date: 21 December 2015

Modulation of neurotrophic signaling pathways by polyphenols

Moosavi F, Hosseini R, Saso L, Firuzi O

Drug Design, Development and Therapy 2016, 10:23-42

Published Date: 21 December 2015

Plasmid pORF-hTRAIL targeting to glioma using transferrin-modified polyamidoamine dendrimer

Gao S, Li J, Jiang C, Hong B, Hao B

Drug Design, Development and Therapy 2016, 10:1-11

Published Date: 17 December 2015

Brivaracetam: review of its pharmacology and potential use as adjunctive therapy in patients with partial onset seizures [Corrigendum]

Mumoli L, Palleria C, Gasparini S, Citraro R, Labate A, Ferlazzo E, Gambardella A, De Sarro G, Russo E

Drug Design, Development and Therapy 2015, 9:6509-6510

Published Date: 18 December 2015

Association of systolic blood pressure drop with intravenous administration of itraconazole in children with hemato-oncologic disease

Lee HJ, Lee B, Park JD, Jeong HJ, Choi YH, Ju HY, Hong CR, Lee JW, Kim H, Suh DI, Park KD, Kang HJ, Shin HY, Ahn HS

Drug Design, Development and Therapy 2015, 9:6489-6495

Published Date: 17 December 2015

Effect of caffeic acid phenethyl ester on bone formation in the expanded inter-premaxillary suture

Kazancioglu HO, Aksakalli S, Ezirganli S, Birlik M, Esrefoglu M, Acar AH

Drug Design, Development and Therapy 2015, 9:6483-6488

Published Date: 21 December 2015

Effects of vitamin C treatment on collar-induced intimal thickening

Arun MZ, Üstünes L, Sevin G, Özer E

Drug Design, Development and Therapy 2015, 9:6461-6473

Published Date: 15 December 2015

Enhanced antitumoral activity of doxorubicin against lung cancer cells using biodegradable poly(butylcyanoacrylate) nanoparticles

Melguizo C, Cabeza L, Prados J, Ortiz R, Caba O, Rama AR, Delgado ÁV, Arias JL

Drug Design, Development and Therapy 2015, 9:6433-6444

Published Date: 14 December 2015

Autophagy facilitates lung adenocarcinoma resistance to cisplatin treatment by activation of AMPK/mTOR signaling pathway

Wu T, Wang MC, Jing L, Liu ZY, Guo H, Liu Y, Bai YY, Cheng YZ, Nan KJ, Liang X

Drug Design, Development and Therapy 2015, 9:6421-6431

Published Date: 14 December 2015

Idiopathic pulmonary fibrosis: current treatment options and critical appraisal of nintedanib

Bonella F, Stowasser S, Wollin L

Drug Design, Development and Therapy 2015, 9:6407-6419

Published Date: 14 December 2015

Phase II trial of docetaxel combined with nedaplatin for patients with recurrent and metastatic nasopharyngeal carcinoma

Peng PJ, Lv BJ, Tang C, Liao H, Lin Z, Liu YM, Wang ZH, Wang SY, Cheng ZB

Drug Design, Development and Therapy 2015, 9:6401-6405

Published Date: 10 December 2015

Identification of covalent active site inhibitors of dengue virus protease

Koh-Stenta X, Joy J, Wang SF, Kwek PZ, Wee JLK, Wan KF, Gayen S, Chen AS, Kang C, Lee MA, Poulsen A, Vasudevan SG, Hill J, Nacro K

Drug Design, Development and Therapy 2015, 9:6389-6399

Published Date: 10 December 2015

Effect of oral N-acetylcysteine on COPD patients with microsatellite polymorphism in the heme oxygenase-1 gene promoter

Zhang JQ, Zhang JQ, Fang LZ, Liu L, Fu WP, Dai LM

Drug Design, Development and Therapy 2015, 9:6379-6387

Published Date: 7 December 2015

Effects of intravitreal injection of netrin-1 in retinal neovascularization of streptozotocin-induced diabetic rats

Yu Y, Zou J, Han Y, Quyang L, He H, Hu P, Shao Y, Tu P

Drug Design, Development and Therapy 2015, 9:6363-6377

Published Date: 7 December 2015

Tanshinone IIA ameliorates dextran sulfate sodium-induced inflammatory bowel disease via the pregnane X receptor

Zhang X, Wang Y, Ma Z, Liang Q, Tang X, Hu D, Tan H, Xiao C, Gao Y

Drug Design, Development and Therapy 2015, 9:6343-6362

Published Date: 7 December 2015

Hypoglycemic effect and mechanism of honokiol on type 2 diabetic mice

Sun J, Fu X, Liu Y, Wang Y, Huo B, Guo Y, Gao X, Li W, Hu X

Drug Design, Development and Therapy 2015, 9:6327-6342

Published Date: 4 December 2015

Green tea extract as a treatment for patients with wild-type transthyretin amyloidosis: an observational study

aus dem Siepen F, Bauer R, Aurich M, Buss SJ, Steen H, Altland K, Katus HA, Kristen AV

Drug Design, Development and Therapy 2015, 9:6319-6325

Published Date: 4 December 2015

Ginkgo biloba extract mitigates liver fibrosis and apoptosis by regulating p38 MAPK, NF-κB/IκBα, and Bcl-2/Bax signaling

Wang YY, Wang R, Wang YJ, Peng RQ, Wu Y, Yuan YF

Drug Design, Development and Therapy 2015, 9:6303-6317

Published Date: 3 December 2015

Synthetic biology for pharmaceutical drug discovery

Trosset JY, Carbonell P

Drug Design, Development and Therapy 2015, 9:6285-6302

Published Date: 3 December 2015

Sulodexide therapy for the treatment of diabetic nephropathy, a meta-analysis and literature review

Li R, Xing J, Mu XJ, Wang H, Zhang L, Zhao Y, Zhang Y

Drug Design, Development and Therapy 2015, 9:6275-6283

Published Date: 3 December 2015

Enzymatic vitreolysis with recombinant tissue plasminogen activator for vitreomacular traction

Raczyńska D, Lipowski P, Zorena K, Skorek A, Glasner P

Drug Design, Development and Therapy 2015, 9:6259-6268

Published Date: 27 November 2015

Timosaponin B-II ameliorates diabetic nephropathy via TXNI P, mTOR, and NF-κB signaling pathways in alloxan-induced mice

Yuan YL, Guo CR, Cui LL, Ruan SX, Zhang CF, Ji D, Yang ZL, Li F

Drug Design, Development and Therapy 2015, 9:6247-6258

Published Date: 27 November 2015

Hyaluronic acid abrogates ethanol-dependent inhibition of collagen biosynthesis in cultured human fibroblasts

Donejko M, Przylipiak A, Rysiak E, Miltyk W, Galicka E, Przylipiak J, Zaręba I, Surazynski A

Drug Design, Development and Therapy 2015, 9:6225-6233

Published Date: 24 November 2015

Different effects of statins on induction of diabetes mellitus: an experimental study

Zhao W, Zhao SP

Drug Design, Development and Therapy 2015, 9:6211-6223

Published Date: 24 November 2015

Radiotherapy potentiation with weekly cisplatin compared to standard every 3 weeks cisplatin chemotherapy for locoregionally advanced head and neck squamous cell carcinoma 

Fayette J, Molin Y, Lavergne E, Montbarbon X, Racadot S, Poupart M, Ramade A, Zrounba P, Ceruse P, Pommier P

Drug Design, Development and Therapy 2015, 9:6203-6210

Published Date: 26 November 2015

Synthesis, structural characterization, and anticancer activity of a monobenzyltin compound against MCF-7 breast cancer cells

Fani S, Kamalidehghan B, Lo KM, Hashim NM, Chow KM, Ahmadipour F

Drug Design, Development and Therapy 2015, 9:6191-6201

Published Date: 23 November 2015

Spotlight on tavaborole for the treatment of onychomycosis

Jinna S, Finch J

Drug Design, Development and Therapy 2015, 9:6185-6190

Published Date: 20 November 2015

Prospective study on nanoparticle albumin-bound paclitaxel in advanced breast cancer: clinical results and biological observations in taxane-pretreated patients

Fabi A, Giannarelli D, Malaguti P, Ferretti G, Vari S, Papaldo P, Nisticò C, Caterino M, De Vita R, Mottolese M, Iacorossi L, Cognetti F

Drug Design, Development and Therapy 2015, 9:6177-6183

Published Date: 20 November 2015

Influence of glucosamine on the bioactivity of insulin delivered subcutaneously and in an oral nanodelivery system

Al-Kurdi ZI, Chowdhry BZ, Leharne SA, Qinna NA, Al Omari MMH, Badwan AA

Drug Design, Development and Therapy 2015, 9:6167-6176

Published Date: 19 November 2015

Efficacy and safety of a conversion from the original tacrolimus and mycophenolate mofetil to the generics Tacpan® and Mowel® after liver transplantation

Vollmar J, Bellmann MC, Darstein F, Hoppe-Lotichius M, Mittler J, Heise M, Rüttger B, Weyer V, Zimmermann A, Lang H, Galle PR, Zimmermann T

Drug Design, Development and Therapy 2015, 9:6139-6149

Published Date: 17 November 2015

DNAzyme-based probe for circulating microRNA detection in peripheral blood

Shao G, Ji S, Wu A, Liu C, Wang M, Zhang P, Jiao Q, Kang Y

Drug Design, Development and Therapy 2015, 9:6109-6117

Published Date: 16 November 2015

Protective effects of triptolide on retinal ganglion cells in a rat model of chronic glaucoma

Yang F, Wang DM, Wu LL, Li Y

Drug Design, Development and Therapy 2015, 9:6095-6107

Published Date: 16 November 2015

Apatinib for molecular targeted therapy in tumor

Zhang H

Drug Design, Development and Therapy 2015, 9:6075-6081

Published Date: 13 November 2015

A single-arm Phase II validation study of preventing oxaliplatin-induced hypersensitivity reactions by dexamethasone: the AVOID trial

Yoshida Y, Hirata K, Matsuoka H, Iwamoto S, Kotaka M, Fujita H, Aisu N, Hoshino S, Kosaka T, Maeda K, Kiyomi F, Yamashita Y

Drug Design, Development and Therapy 2015, 9:6067-6073

Published Date: 12 November 2015

Attenuation of myocardial fibrosis with curcumin is mediated by modulating expression of angiotensin II AT1/AT2 receptors and ACE2 in rats

Pang XF, Zhang LH, Bai F, Wang NP, Garner RE, McKallip RJ, Zhao ZQ

Drug Design, Development and Therapy 2015, 9:6043-6054

Published Date: 11 November 2015

Profile of suvorexant in the management of insomnia

Sutton EL

Drug Design, Development and Therapy 2015, 9:6035-6042

Published Date: 11 November 2015

6-Gingerol alleviates exaggerated vasoconstriction in diabetic rat aorta through direct vasodilation and nitric oxide generation

Ghareib SA, El-Bassossy HM, Elberry AA, Azhar A, Watson ML, Banjar ZM

Drug Design, Development and Therapy 2015, 9:6019-6026

Published Date: 9 November 2015

Glucose abnormalities in Asian patients with chronic hepatitis C

Bo Q, Orsenigo R, Wang J, Griffel L, Brass C

Drug Design, Development and Therapy 2015, 9:6009-6017

Published Date: 9 November 2015

Progesterone regulates the proliferation of breast cancer cells – in vitro evidence

Azeez JM, Sithul H, Hariharan I, Sreekumar S, Prabhakar J, Sreeja S, Pillai MR

Drug Design, Development and Therapy 2015, 9:5987-5999

Published Date: 9 November 2015

Phytocompounds and modulatory effects of Anacardium microcarpum (cajui) on antibiotic drugs used in clinical infections

Barbosa-Filho VM, Waczuk EP, Leite NF, Menezes IRA, da Costa JGM, Lacerda SR, Adedara IA, Coutinho HDM, Posser T, Kamdem JP

Drug Design, Development and Therapy 2015, 9:5965-5972

Published Date: 6 November 2015

Lentinus squarrosulus (Mont.) mycelium enhanced antioxidant status in rat model

Mhd Omar NA, Abdullah S, Abdullah N, Kuppusamy UR, Abdulla MA, Sabaratnam V

Drug Design, Development and Therapy 2015, 9:5957-5964

Published Date: 6 November 2015

Tumor-induced VEGF-C overexpression in retroperitoneal lymph nodes in VX2 carcinoma-bearing rabbits

Huang YW, Zhou Y, Lan CY, Wang Y, Feng YL, Luo RZ, Liu JH

Drug Design, Development and Therapy 2015, 9:5949-5956

Published Date: 5 November 2015

Systematic review and meta-analysis: bezafibrate in patients with primary biliary cirrhosis [Erratum]

Yin Q, Li J, Xia Y, Zhang R, Wang J, Lu W, Zhou Y, Zheng Y, Abudumijiti H, Chen R, Chen K, Li S, Liu T, Wang F, Lu J, Zhou Y, Guo C

Drug Design, Development and Therapy 2015, 9:5947-5948

Published Date: 9 November 2015

Efficacy and safety of ifosfamide-based chemotherapy for osteosarcoma: a meta-analysis

Fan XL, Cai GP, Zhu LL, Ding GM

Drug Design, Development and Therapy 2015, 9:5925-5932

Published Date: 4 November 2015

PACE4 regulates apoptosis in human prostate cancer cells via endoplasmic reticulum stress and mitochondrial signaling pathways

Yao Z, Sun B, Hong Q, Yan J, Mu D, Li J, Sheng H, Guo H

Drug Design, Development and Therapy 2015, 9:5911-5923

Published Date: 5 November 2015

Critical appraisal of Timothy grass pollen extract GRAZAX® in the management of allergic rhinitis

Scaparrotta A, Attanasi M, Petrosino MI, Di Filippo P, Di Pillo S, Chiarelli F

Drug Design, Development and Therapy 2015, 9:5897-5909

Published Date: 3 November 2015

In silico approach for the discovery of new PPARγ modulators among plant-derived polyphenols

Encinar JA, Fernández-Ballester G, Galiano-Ibarra V, Micol V

Drug Design, Development and Therapy 2015, 9:5877-5895

Published Date: 4 November 2015

Efficacy and tolerability of oral oxycodone and oxycodone/naloxone combination in opioid-naïve cancer patients: a propensity analysis

Lazzari M, Greco MT, Marcassa C, Finocchi S, Caldarulo C, Corli O

Drug Design, Development and Therapy 2015, 9:5863-5872

Published Date: 2 November 2015

Arsenic sulfide combined with JQ1, chemotherapy agents, or celecoxib inhibit gastric and colon cancer cell growth

Zhang L, Tong Y, Zhang X, Pan M, Chen S

Drug Design, Development and Therapy 2015, 9:5851-5862

Published Date: 30 October 2015

The relevance of piroxicam for the prevention and treatment of nonmelanoma skin cancer and its precursors

Campione E, Paternò EJ, Candi E, Falconi M, Costanza G, Diluvio L, Terrinoni A, Bianchi L, Orlandi A

Drug Design, Development and Therapy 2015, 9:5843-5850

Published Date: 29 October 2015

Prevalence of the rs7903146C>T polymorphism in TCF7L2 gene for prediction of type 2 diabetes risk among Iranians of different ethnicities

Allahdini M, Kamalidehghan B, Akbari L, Azadfar P, Rahmani A, Ahmadipour F, Meng GY, Masserrat A, Houshmand M

Drug Design, Development and Therapy 2015, 9:5835-5841

Published Date: 28 October 2015

Development of oral dispersible tablets containing prednisolone nanoparticles for the management of pediatric asthma

Chen YD, Liang ZY, Cen YY, Zhang H, Han MG, Tian YQ, Zhang J, Li SJ, Yang DS

Drug Design, Development and Therapy 2015, 9:5815-5825

Published Date: 20 November 2015

Curcuma purpurascens BI. rhizome accelerates rat excisional wound healing: involvement of Hsp70/Bax proteins, antioxidant defense, and angiogenesis activity

Rouhollahi E, Moghadamtousi SZ, Hajiaghaalipour F, Zahedifard M, Tayeby F, Awang K, Abdulla MA, Mohamed Z

Drug Design, Development and Therapy 2015, 9:5805-5813

Published Date: 27 October 2015

Empagliflozin in the treatment of type 2 diabetes: evidence to date

Shubrook JH, Baradar Bokaie B, Adkins SE

Drug Design, Development and Therapy 2015, 9:5793-5803

Published Date: 30 October 2015

Efficacy of trabectedin in advanced soft tissue sarcoma: beyond lipo- and leiomyosarcoma

De Sanctis R, Marrari A, Marchetti S, Mussi C, Balzarini L, Lutman FR, Daolio P, Bastoni S, Bertuzzi AF, Quagliuolo V, Santoro A

Drug Design, Development and Therapy 2015, 9:5785-5791

Published Date: 27 October 2015

Reductive metabolism of oxymatrine is catalyzed by microsomal CYP3A4

Liu W, Shi J, Zhu L, Dong L, Luo F, Zhao M, Wang Y, Hu M, Lu L, Liu Z

Drug Design, Development and Therapy 2015, 9:5771-5783

Published Date: 30 October 2015

Rationale and clinical utility of the darunavir–cobicistat combination in the treatment of HIV/AIDS

Putcharoen O, Do T, Avihingsanon A, Ruxrungtham K

Drug Design, Development and Therapy 2015, 9:5763-5769

Published Date: 23 October 2015

Efficacy of thrombomodulin for acute exacerbation of idiopathic pulmonary fibrosis and nonspecific interstitial pneumonia: a nonrandomized prospective study

Abe M, Tsushima K, Matsumura T, Ishiwata T, Ichimura Y, Ikari J, Terada J, Tada Y, Sakao S, Tanabe N, Tatsumi K

Drug Design, Development and Therapy 2015, 9:5755-5762

Published Date: 23 October 2015

Mechanism and pharmacological rescue of berberine-induced hERG channel deficiency

Yan M, Zhang KP, Shi YH, Feng LF, Lv L, Li BX

Drug Design, Development and Therapy 2015, 9:5737-5747

Published Date: 22 October 2015

4-Hydroxyisoleucine ameliorates an insulin resistant-like state in 3T3-L1 adipocytes by regulating TACE/TIMP3 expression

Gao F, Du W, Zafar MI, Shafqat RA, Jian L, Cai Q, Lu FR

Drug Design, Development and Therapy 2015, 9:5727-5736

Published Date: 20 October 2015

Brivaracetam: review of its pharmacology and potential use as adjunctive therapy in patients with partial onset seizures

Mumoli L, Palleria C, Gasparini S, Citraro R, Labate A, Ferlazzo E, Gambardella A, De Sarro G, Russo E

Drug Design, Development and Therapy 2015, 9:5719-5725

Published Date: 19 October 2015

Evaluation of the cardiovascular effects of varenicline in rats

Selçuk EB, Sungu M, Parlakpinar H, Ermiş N, Taslıdere E, Vardı N, Yalçınsoy M, Sagır M, Polat A, Karatas M, Kayhan-Tetik B

Drug Design, Development and Therapy 2015, 9:5705-5717

Published Date: 22 October 2015

Safety and pharmacokinetics of dicloxacillin in healthy Chinese volunteers following single and multiple oral doses

Wu GL, Zheng YL, Zhou HL, Hu XJ, Liu J, Zhai Y, Zhu MX, Wu LH, Shentu JZ

Drug Design, Development and Therapy 2015, 9:5687-5695

Published Date: 16 October 2015

Bifunctional fused polypeptide inhibits the growth and metastasis of breast cancer

Liang AL, Qian HL, Zhang TT, Zhou N, Wang HJ, Men XT, Qi W, Zhang PP, Fu M, Liang X, Lin C, Liu YJ

Drug Design, Development and Therapy 2015, 9:5671-5686

Published Date: 16 October 2015

The role of taxanes in triple-negative breast cancer: literature review [Corrigendum]

Mustacchi G, De Laurentiis M

Drug Design, Development and Therapy 2015, 9:5669-5670

Published Date: 19 October 2015

Adenoviral delivery of truncated MMP-8 fused with the hepatocyte growth factor mutant 1K1 ameliorates liver cirrhosis and promotes hepatocyte proliferation

Liu JH, Li JB, Fu WW, Tang JC, Feng X, Chen J, Liang YL, Jin RA, Xie AY, Cai XJ

Drug Design, Development and Therapy 2015, 9:5655-5667

Published Date: 16 October 2015

Development of PPAR-agonist GW0742 as antidiabetic drug: study in animals

Niu HS, Ku PM, Niu CS, Cheng JT, Lee KS

Drug Design, Development and Therapy 2015, 9:5625-5632

Published Date: 14 October 2015

Paeoniflorin inhibits human glioma cells via STAT3 degradation by the ubiquitin–proteasome pathway

Nie XH, Ou-yang J, Xing Y, Li DY, Dong XY, Liu RE, Xu RX

Drug Design, Development and Therapy 2015, 9:5611-5622

Published Date: 13 October 2015

Urinary kallidinogenase for the treatment of cerebral arterial stenosis

Zhao L, Zhao Y, Wan Q, Zhang H

Drug Design, Development and Therapy 2015, 9:5595-5600

Published Date: 13 October 2015

Acquired latent tuberculosis infection in psoriasis patients treated with etanercept in the People’s Republic of China

Li CR, Mao QX, Chen M, Jia WX, Yao X, Feng SY, Jia H, Gong JQ, Yang XY

Drug Design, Development and Therapy 2015, 9:5591-5594

Published Date: 12 October 2015

Arsenic sulfide inhibits cell migration and invasion of gastric cancer in vitro and in vivo

Zhang L, Kim S, Ding W, Tong Y, Zhang X, Pan M, Chen S

Drug Design, Development and Therapy 2015, 9:5579-5590

Published Date: 9 October 2015

Novel dehydroepiandrosterone troche supplementation improves the serum androgen profile of women undergoing in vitro fertilization

Keane KN, Hinchliffe PM, Namdar N, Conceicao JL, Newsholme P, Yovich JL

Drug Design, Development and Therapy 2015, 9:5569-5578

Published Date: 9 October 2015

Design, synthesis, and antitumor evaluation of histone deacetylase inhibitors with L-phenylglycine scaffold

Zhang Y, Li X, Hou J, Huang Y, Xu W

Drug Design, Development and Therapy 2015, 9:5553-5567

Published Date: 8 October 2015

Plumbagin suppresses epithelial to mesenchymal transition and stemness via inhibiting Nrf2-mediated signaling pathway in human tongue squamous cell carcinoma cells

Pan ST, Qin Y, Zhou ZW, He ZX, Zhang X, Yang T, Yang YX, Wang D, Zhou SF, Qiu JX

Drug Design, Development and Therapy 2015, 9:5511-5551

Published Date: 5 October 2015

Neuroprotective potential of ferulic acid in the rotenone model of Parkinson’s disease

Ojha S, Javed H, Azimullah S, Abul Khair SB, Haque ME

Drug Design, Development and Therapy 2015, 9:5499-5510

Published Date: 7 October 2015

3-Coumaranone derivatives as inhibitors of monoamine oxidase

Van Dyk AS, Petzer JP, Petzer A, Legoabe LJ

Drug Design, Development and Therapy 2015, 9:5479-5489

Published Date: 3 October 2015

A novel small-molecule inhibitor of HIV-1 entry

Heredia A, Latinovic OS, Barbault F, de Leeuw EPH

Drug Design, Development and Therapy 2015, 9:5469-5478

Published Date: 1 October 2015

Maraviroc: a review of its use in HIV infection and beyond

Woollard SM, Kanmogne GD

Drug Design, Development and Therapy 2015, 9:5447-5468

Published Date: 1 October 2015

A proposal for an individualized pharmacogenetic-guided isoniazid dosage regimen for patients with tuberculosis

Jung JA, Kim TE, Lee H, Jeong BH, Park HY, Jeon K, Kwon OJ, Ko JW, Choi R, Woo HI, Koh WJ, Lee SY

Drug Design, Development and Therapy 2015, 9:5433-5438

Published Date: 30 September 2015

Systematic review and meta-analysis: bezafibrate in patients with primary biliary cirrhosis

Yin Q, Li J, Xia Y, Zhang R, Wang J, Lu W, Zhou Y, Zheng Y, Abudumijiti H, Chen R, Chen K, Li S, Liu T, Wang F, Lu J, Zhou Y, Guo C

Drug Design, Development and Therapy 2015, 9:5407-5419

Published Date: 30 September 2015

Ghrelin reduces liver impairment in a model of concanavalin A-induced acute hepatitis in mice

Mao YQ, Wang JB, Yu FJ, Cheng J, Li HQ, Guo CY, Fan XM

Drug Design, Development and Therapy 2015, 9:5385-5396

Published Date: 28 September 2015

Collagenase IV plays an important role in regulating hair cycle by inducing VEGF, IGF-1, and TGF-β expression

Hou C, Miao Y, Wang J, Wang X, Chen CY, Hu ZQ

Drug Design, Development and Therapy 2015, 9:5373-5383

Published Date: 25 September 2015

Efficacy and safety of a vaginal medicinal product containing three strains of probiotic bacteria: a multicenter, randomized, double-blind, and placebo-controlled trial

Tomusiak A, Strus M, Heczko PB, Adamski P, Stefański G, Mikołajczyk-Cichońska A, Suda-Szczurek M

Drug Design, Development and Therapy 2015, 9:5345-5354

Published Date: 25 September 2015

Effect of curcumin on aging retinal pigment epithelial cells

Zhu W, Wu Y, Meng YF, Wang JY, Xu M, Tao JJ, Lu J

Drug Design, Development and Therapy 2015, 9:5337-5344

Published Date: 25 September 2015

Investigation of the bioequivalence of montelukast chewable tablets after a single oral administration using a validated LC-MS/MS method

Zaid AN, Abualhasan MN, Watson DG, Mousa A, Ghazal N, Bustami R

Drug Design, Development and Therapy 2015, 9:5315-5321

Published Date: 23 September 2015

Chamaejasmin B exerts anti-MDR effect in vitro and in vivo via initiating mitochondria-dependant intrinsic apoptosis pathway

Wang YJ, Li Q, Xiao HB, Li YJ, Yang Q, Kan XX, Chen Y, Liu XN, Weng XG, Chen X, Cai WY, Guo Y, Huang HF, Zhu XX

Drug Design, Development and Therapy 2015, 9:5301-5313

Published Date: 22 September 2015

The rapid effects of budesonide plus formoterol in patients with obstructive airway diseases

Bayiz H, Ozkaya S, Dirican A, Ece F

Drug Design, Development and Therapy 2015, 9:5287-5290

Published Date: 21 September 2015

Exposure–outcome analysis in depressed patients treated with paroxetine using population pharmacokinetics

Kim JR, Woo HI, Chun MR, Lim SW, Kim HD, Na HS, Chung MW, Myung W, Lee SY, Kim DK

Drug Design, Development and Therapy 2015, 9:5247-5254

Published Date: 16 September 2015

Companion diagnostics and molecular imaging-enhanced approaches for oncology clinical trials

Van Heertum RL, Scarimbolo R, Ford R, Berdougo E, O’Neal M

Drug Design, Development and Therapy 2015, 9:5215-5223

Published Date: 11 September 2015

Eliglustat tartrate for the treatment of adults with type 1 Gaucher disease [Corrigendum]

Bennett LL, Turcotte K

Drug Design, Development and Therapy 2015, 9:5213-5214

Published Date: 11 September 2015

Dabigatran etexilate retards the initiation and progression of atherosclerotic lesions and inhibits the expression of oncostatin M in apolipoprotein E-deficient mice

Preusch MR, Ieronimakis N, Wijelath ES, Cabbage S, Ricks J, Bea F, Reyes M, van Ryn J, Rosenfeld ME

Drug Design, Development and Therapy 2015, 9:5203-5211

Published Date: 10 September 2015

Pentoxifylline and electromagnetic field improved bone fracture healing in rats

Atalay Y, Gunes N, Guner MD, Akpolat V, Celik MS, Guner R

Drug Design, Development and Therapy 2015, 9:5195-5201

Published Date: 9 September 2015

Exposure–response model for sibutramine and placebo: suggestion for application to long-term weight-control drug development

Han S, Jeon S, Hong T, Lee J, Bae SH, Park WS, Park G, Youn S, Jang DY, Kim KS, Yim DS

Drug Design, Development and Therapy 2015, 9:5185-5194

Published Date: 9 September 2015

Regulation of bone formation by baicalein via the mTORC1 pathway

Li SF, Tang JJ, Chen J, Zhang P, Wang T, Chen TY, Yan B, Huang B, Wang L, Huang MJ, Zhang ZM, Jin DD

Drug Design, Development and Therapy 2015, 9:5169-5183

Published Date: 9 September 2015

The IL-17A G-197A and IL-17F 7488T/C polymorphisms are associated with increased risk of cancer in Asians: a meta-analysis

Wang H, Zhang Y, Liu Z, Zhang Y, Zhao H, Du S

Drug Design, Development and Therapy 2015, 9:5159-5168

Published Date: 24 September 2015

Icariside II ameliorates diabetic nephropathy in streptozotocin-induced diabetic rats

Tian W, Lei H, Guan R, Xu Y, Li H, Wang L, Yang B, Gao Z, Xin Z

Drug Design, Development and Therapy 2015, 9:5147-5157

Published Date: 7 September 2015

Novel synthesizing method of pH-dependent doxorubicin-loaded anti-CD22-labelled drug delivery nanosystem

Sun M, Wang J, Lu Q, Xia G, Zhang Y, Song L, Fang Y

Drug Design, Development and Therapy 2015, 9:5123-5133

Published Date: 7 September 2015

Anthocyanins inhibit high-glucose-induced cholesterol accumulation and inflammation by activating LXRα pathway in HK-2 cells

Du C, Shi Y, Ren Y, Wu H, Yao F, Wei J, Wu M, Hou Y, Duan H

Drug Design, Development and Therapy 2015, 9:5099-5113

Published Date: 4 September 2015

Phase III study of pasireotide long-acting release in patients with metastatic neuroendocrine tumors and carcinoid symptoms refractory to available somatostatin analogues

Wolin EM, Jarzab B, Eriksson B, Walter T, Toumpanakis C, Morse MA, Tomassetti P, Weber MM, Fogelman DR, Ramage J, Poon D, Gadbaw B, Li J, Pasieka JL, Mahamat A, Swahn F, Newell-Price J, Mansoor W, Öberg K

Drug Design, Development and Therapy 2015, 9:5075-5086

Published Date: 3 September 2015

Paeonia lactiflora Pall. protects against ANIT-induced cholestasis by activating Nrf2 via PI3K/Akt signaling pathway

Ma X, Zhao Y, Zhu Y, Chen Z, Wang J, Li R, Chen C, Wei S, Li J, Liu B, Wang R, Li Y, Wang L, Xiao X

Drug Design, Development and Therapy 2015, 9:5061-5074

Published Date: 2 September 2015

Inhibition of HIV-1 by curcumin A, a novel curcumin analog

Kumari N, Kulkarni AA, Lin X, McLean C, Ammosova T, Ivanov A, Hipolito M, Nekhai S, Nwulia E

Drug Design, Development and Therapy 2015, 9:5051-5060

Published Date: 3 September 2015

Pharmacokinetic and nephroprotective benefits of using Schisandra chinensis extracts in a cyclosporine A-based immune-suppressive regime

Lai Q, Wei JB, Mahmoodurrahman M, Zhang CX, Quan SJ, Li TM, Yu Y

Drug Design, Development and Therapy 2015, 9:4997-5018

Published Date: 28 August 2015

CXCR4 in breast cancer: oncogenic role and therapeutic targeting

Xu C, Zhao H, Chen H, Yao Q

Drug Design, Development and Therapy 2015, 9:4953-4964

Published Date: 28 August 2015

Insight into the mechanism of polyphenols on the activity of HMGR by molecular docking

Islam B, Sharma C, Adem A, Aburawi EH, Ojha S

Drug Design, Development and Therapy 2015, 9:4943-4951

Published Date: 28 August 2015

The effect of curcumin and its nanoformulation on adjuvant-induced arthritis in rats

Zheng ZL, Sun YH, Liu ZL, Zhang MQ, Li CQ, Cai H

Drug Design, Development and Therapy 2015, 9:4931-4942

Published Date: 27 August 2015

Immunosuppressive effects of the standardized extract of Phyllanthus amarus on cellular immune responses in Wistar-Kyoto rats

Ilangkovan M, Jantan I, Mesaik MA, Bukhari SNA

Drug Design, Development and Therapy 2015, 9:4917-4930

Published Date: 26 August 2015

Profile of omalizumab in the treatment of chronic spontaneous urticaria

Labrador-Horrillo M, Ferrer M

Drug Design, Development and Therapy 2015, 9:4909-4915

Published Date: 25 August 2015

Met tyrosine kinase inhibitor, PF-2341066, suppresses growth and invasion of nasopharyngeal carcinoma

Zhao Y, Zhang J, Tian Y, Xue C, Hu Z, Zhang L

Drug Design, Development and Therapy 2015, 9:4897-4907

Published Date: 26 August 2015

Hydrogen sulfide-releasing naproxen suppresses colon cancer cell growth and inhibits NF-κB signaling

Kodela R, Nath N, Chattopadhyay M, Nesbitt DE, Velázquez-Martínez CA, Kashfi K

Drug Design, Development and Therapy 2015, 9:4873-4882

Published Date: 24 August 2015

Blood pyrrole-protein adducts as a diagnostic and prognostic index in pyrrolizidine alkaloid-hepatic sinusoidal obstruction syndrome

Gao H, Ruan JQ, Chen J, Li N, Ke CQ, Ye Y, Lin G, Wang JY

Drug Design, Development and Therapy 2015, 9:4861-4868

Published Date: 25 August 2015

Nonalcoholic steatohepatitis: emerging targeted therapies to optimize treatment options

Milic S, Mikolasevic I, Krznaric-Zrnic I, Stanic M, Poropat G, Stimac D, Vlahovic-Palcevski V, Orlic L

Drug Design, Development and Therapy 2015, 9:4835-4845

Published Date: 20 August 2015

How we make cell therapy in Italy

Montemurro T, Viganò M, Budelli S, Montelatici E, Lavazza C, Marino L, Parazzi V, Lazzari L, Giordano R

Drug Design, Development and Therapy 2015, 9:4825-4834

Published Date: 20 August 2015

Role of short-acting nitroglycerin in the management of ischemic heart disease

Boden WE, Padala SK, Cabral KP, Buschmann IR, Sidhu MS

Drug Design, Development and Therapy 2015, 9:4793-4805

Published Date: 19 August 2015

High glucose inhibits ClC-2 chloride channels and attenuates cell migration of rat keratinocytes

Pan F, Guo R, Cheng W, Chai L, Wang W, Cao C, Li S

Drug Design, Development and Therapy 2015, 9:4779-4791

Published Date: 28 August 2015

Effects of chalcone derivatives on players of the immune system

Lee JS, Bukhari SNA, Fauzi NM

Drug Design, Development and Therapy 2015, 9:4761-4778

Published Date: 19 August 2015

Death receptor and mitochondria-mediated hepatocyte apoptosis underlies liver dysfunction in rats exposed to organic pollutants from drinking water

Yang GH, Zhou ZW, Cen YL, Gui XL, Zeng QB, Ao YX, Li Q, Wang SR, Li J, Zhang AH

Drug Design, Development and Therapy 2015, 9:4719-4733

Published Date: 18 August 2015

Development of telmisartan in the therapy of spinal cord injury: pre-clinical study in rats

Lin CM, Tsai JT, Chang CK, Cheng JT, Lin JW

Drug Design, Development and Therapy 2015, 9:4709-4717

Published Date: 14 August 2015

Paget’s disease of bone: an osteoimmunological disorder?

Numan MS, Amiable N, Brown JP, Michou L

Drug Design, Development and Therapy 2015, 9:4695-4707

Published Date: 14 August 2015

Enhancement of absorption and bioavailability of echinacoside by verapamil or clove oil

Shen JY, Yang XL, Yang ZL, Kou JP, Li F

Drug Design, Development and Therapy 2015, 9:4685-4693

Published Date: 14 August 2015

Treatment with metformin and a dipeptidyl peptidase-4 inhibitor elevates apelin levels in patients with type 2 diabetes mellitus

Fan YJ, Zhang Y, Li XS, Zheng H, Song YP, Zhang N, Shen CF, Fan XF, Ren FD, Shen JY, Ren GG, Yang JL

Drug Design, Development and Therapy 2015, 9:4679-4683

Published Date: 14 August 2015

Lefty-1 alleviates TGF-β1-induced fibroblast–myofibroblast transdifferentiation in NRK-49F cells

Zhang LJ, Zhang J, Xu CG, Zhou XJ, Wang W, Zheng RP, Hu W, Wu P

Drug Design, Development and Therapy 2015, 9:4669-4678

Published Date: 14 August 2015

Myofibrotic malformation vessels: unique angiodysplasia toward the progression of hemorrhoidal disease

Li SL, Jing FY, Ma LL, Guo LL, Na F, An SL, Ye Y, Yang JM, Bao M, Kang D, Sun XL, Deng YJ

Drug Design, Development and Therapy 2015, 9:4649-4656

Published Date: 13 August 2015

Eliglustat tartrate for the treatment of adults with type 1 Gaucher disease

Bennett LL, Turcotte K

Drug Design, Development and Therapy 2015, 9:4639-4647

Published Date: 18 August 2015

PTEN insufficiency modulates ER+ breast cancer cell cycle progression and increases cell growth in vitro and in vivo

Chiang KC, Chen HY, Hsu SY, Pang JHS, Wang SY, Hsu JT, Yeh TS, Chen LW, Kuo SF, Sun CC, Lee JM, Yeh CN, Juang HH

Drug Design, Development and Therapy 2015, 9:4631-4638

Published Date: 13 August 2015

RGD-modified liposomes enhance efficiency of aclacinomycin A delivery: evaluation of their effect in lung cancer

Feng C, Li X, Dong C, Zhang X, Zhang X, Gao Y

Drug Design, Development and Therapy 2015, 9:4613-4620

Published Date: 11 August 2015

Relaxin inhibits cardiac fibrosis and endothelial–mesenchymal transition via the Notch pathway

Zhou X, Chen X, Cai JJ, Chen LZ, Gong YS, Wang LX, Gao Z, Zhang HQ, Huang WJ, Zhou H

Drug Design, Development and Therapy 2015, 9:4599-4611

Published Date: 11 August 2015

Ceftobiprole for the treatment of pneumonia: a European perspective

Liapikou A, Cillóniz C, Torres A

Drug Design, Development and Therapy 2015, 9:4565-4572

Published Date: 18 August 2015

Effects of amoxicillin/clavulanic acid on the pharmacokinetics of valproic acid

Lee SY, Huh W, Jung JA, Yoo HM, Ko JW, Kim JR

Drug Design, Development and Therapy 2015, 9:4559-4563

Published Date: 10 August 2015

Navigating the chemical space of dipeptidyl peptidase-4 inhibitors

Shoombuatong W, Prachayasittikul V, Anuwongcharoen N, Songtawee N, Monnor T, Prachayasittikul S, Prachayasittikul V, Nantasenamat C

Drug Design, Development and Therapy 2015, 9:4515-4549

Published Date: 10 August 2015

Clinical development of galunisertib (LY2157299 monohydrate), a small molecule inhibitor of transforming growth factor-beta signaling pathway

Herbertz S, Sawyer JS, Stauber AJ, Gueorguieva I, Driscoll KE, Estrem ST, Cleverly AL, Desaiah D, Guba SC, Benhadji KA, Slapak CA, Lahn MM

Drug Design, Development and Therapy 2015, 9:4479-4499

Published Date: 10 August 2015

Novel targeting of PEGylated liposomes for codelivery of TGF-β1 siRNA and four antitubercular drugs to human macrophages for the treatment of mycobacterial infection: a quantitative proteomic study

Niu NK, Yin JJ, Yang YX, Wang ZL, Zhou ZW, He ZX, Chen XW, Zhang XJ, Duan W, Yang TX, Zhou SF

Drug Design, Development and Therapy 2015, 9:4441-4470

Published Date: 7 August 2015

Transarterial chemoembolization versus hepatic resection in hepatocellular carcinoma treatment: a meta-analysis

Tian X, Dai Y, Wang D, Zhang L, Sui C, Meng F, Jiang S, Liu Y, Jiang Y

Drug Design, Development and Therapy 2015, 9:4431-4440

Published Date: 10 August 2015

High-throughput sequencing of 16S rDNA amplicons characterizes bacterial composition in cerebrospinal fluid samples from patients with purulent meningitis

Liu A, Wang C, Liang Z, Zhou ZW, Wang L, Ma Q, Wang G, Zhou SF, Wang Z

Drug Design, Development and Therapy 2015, 9:4417-4429

Published Date: 7 August 2015

Tongguan capsule ameliorates coronary artery stenosis in a 40-year-old woman

Ma H, Wang L, Huang DZ, Liu GQ, Zhang MZ

Drug Design, Development and Therapy 2015, 9:4413-4416

Published Date: 10 August 2015

High-throughput virtual screening with e-pharmacophore and molecular simulations study in the designing of pancreatic lipase inhibitors

Veeramachaneni GK, Raj KK, Chalasani LM, Bondili JS, Talluri VR

Drug Design, Development and Therapy 2015, 9:4397-4412

Published Date: 6 August 2015

The role of aflibercept in the management of diabetic macular edema

Chang AA, Hong T, Ewe SY, Bahrami B, Broadhead GK

Drug Design, Development and Therapy 2015, 9:4389-4396

Published Date: 6 August 2015

Gamma scintigraphic evaluation of floating gastroretentive tablets of metformin HCl using a combination of three natural polymers in rabbits

Razavi M, Karimian H, Yeong CH, Chung LY, Nyamathulla S, Noordin MI

Drug Design, Development and Therapy 2015, 9:4373-4386

Published Date: 6 August 2015

The role of taxanes in triple-negative breast cancer: literature review

Mustacchi G, De Laurentiis M

Drug Design, Development and Therapy 2015, 9:4303-4318

Published Date: 5 August 2015

Hidden costs of antiretroviral treatment: the public health efficiency of drug packaging

Andreu-Crespo À, Llibre JM, Cardona-Peitx G, Sala-Piñol F, Clotet B, Bonafont-Pujol X

Drug Design, Development and Therapy 2015, 9:4287-4290

Published Date: 5 August 2015

Development of megestrol acetate solid dispersion nanoparticles for enhanced oral delivery by using a supercritical antisolvent process

Ha ES, Kim JS, Baek I, Yoo JW, Jung Y, Moon HR, Kim MS

Drug Design, Development and Therapy 2015, 9:4269-4277

Published Date: 4 August 2015

Design, synthesis, and anti-melanogenic effects of (E)-2-benzoyl-3-(substituted phenyl)acrylonitriles

Yun HY, Kim DH, Son S, Ullah S, Kim SJ, Kim YJ, Yoo JW, Jung YJ, Chun P, Moon HR

Drug Design, Development and Therapy 2015, 9:4259-4268

Published Date: 4 August 2015

Colon-targeted delivery of piceatannol enhances anti-colitic effects of the natural product: potential molecular mechanisms for therapeutic enhancement

Yum S, Jeong S, Lee S, Nam J, Kim W, Yoo JW, Kim MS, Lee BL, Jung Y

Drug Design, Development and Therapy 2015, 9:4247-4258

Published Date: 4 August 2015

Advances in cancer pain from bone metastasis

Zhu XC, Zhang JL, Ge CT, Yu YY, Wang P, Yuan TF, Fu CY

Drug Design, Development and Therapy 2015, 9:4239-4245

Published Date: 18 August 2015

Evaluation of glycine-bearing celecoxib derivatives as a colon-specific mutual prodrug acting on nuclear factor-κB, an anti-inflammatory target

Lee S, Lee Y, Kim W, Nam J, Jeong S, Yoo JW, Kim MS, Moon HR, Jung Y

Drug Design, Development and Therapy 2015, 9:4227-4237

Published Date: 7 August 2015

Characterization of cubosomes as a targeted and sustained transdermal delivery system for capsaicin

Peng X, Zhou Y, Han K, Qin L, Dian L, Li G, Pan X, Wu C

Drug Design, Development and Therapy 2015, 9:4209-4218

Published Date: 3 August 2015

Nutrigenomic effects of edible bird’s nest on insulin signaling in ovariectomized rats

Hou ZP, Imam MU, Ismail M, Ooi DJ, Ideris A, Mahmud R

Drug Design, Development and Therapy 2015, 9:4115-4125

Published Date: 14 August 2015

Celecoxib coupled to dextran via a glutamic acid linker yields a polymeric prodrug suitable for colonic delivery

Lee Y, Kim J, Kim W, Nam J, Jeong S, Lee S, Yoo JW, Kim MS, Jung Y

Drug Design, Development and Therapy 2015, 9:4105-4113

Published Date: 30 July 2015

20(S)-ginsenoside Rg3 promotes senescence and apoptosis in gallbladder cancer cells via the p53 pathway

Zhang F, Li M, Wu X, Hu Y, Cao Y, Wang X, Xiang S, Li H, Jiang L, Tan Z, Lu W, Weng H, Shu Y, Gong W, Wang X, Zhang Y, Shi W, Dong P, Gu J, Liu Y

Drug Design, Development and Therapy 2015, 9:3969-3987

Published Date: 10 August 2015

Improved oral absorption of cilostazol via sulfonate salt formation with mesylate and besylate

Seo JH, Park JB, Choi WK, Park S, Sung YJ, Oh E, Bae SK

Drug Design, Development and Therapy 2015, 9:3961-3968

Published Date: 30 July 2015

Edible bird’s nest attenuates procoagulation effects of high-fat diet in rats

Yida Z, Imam MU, Ismail M, Ismail N, Hou ZP

Drug Design, Development and Therapy 2015, 9:3951-3959

Published Date: 29 July 2015

Combined treatment with olmesartan medoxomil and amlodipine besylate attenuates atherosclerotic lesion progression in a model of advanced atherosclerosis

Sievers P, Uhlmann L, Korkmaz-Icöz S, Fastner C, Bea F, Blessing E, Katus HA, Preusch MR

Drug Design, Development and Therapy 2015, 9:3935-3942

Published Date: 29 July 2015

Gallic acid attenuates dextran sulfate sodium-induced experimental colitis in BALB/c mice

Pandurangan AK, Mohebali N, Norhaizan ME, Looi CY

Drug Design, Development and Therapy 2015, 9:3923-3934

Published Date: 30 July 2015

The chemopreventive potential of Curcuma purpurascens rhizome in reducing azoxymethane-induced aberrant crypt foci in rats

Rouhollahi E, Moghadamtousi SZ, Al-Henhena N, Kunasegaran T, Hasanpourghadi M, Looi CY, Abd Malek SN, Awang K, Abdulla MA, Mohamed Z

Drug Design, Development and Therapy 2015, 9:3911-3922

Published Date: 27 July 2015

Zinc supplementation induces apoptosis and enhances antitumor efficacy of docetaxel in non-small-cell lung cancer

Kocdor H, Ates H, Aydin S, Cehreli R, Soyarat F, Kemanli P, Harmanci D, Cengiz H, Kocdor MA

Drug Design, Development and Therapy 2015, 9:3899-3909

Published Date: 27 July 2015

Aterofisiol® in carotid plaque evolution

Amato B, Compagna R, Amato M, Gallelli L, de Franciscis S, Serra R

Drug Design, Development and Therapy 2015, 9:3877-3884

Published Date: 23 July 2015

Dendrimer-coupled sonophoresis-mediated transdermal drug-delivery system for diclofenac

Huang B, Dong WJ, Yang GY, Wang W, Ji CH, Zhou FN

Drug Design, Development and Therapy 2015, 9:3867-3876

Published Date: 23 July 2015

The brain signature of paracetamol in healthy volunteers: a double-blind randomized trial

Pickering G, Kastler A, Macian N, Pereira B, Valabrègue R, Lehericy S, Boyer L, Dubray C, Jean B

Drug Design, Development and Therapy 2015, 9:3853-3862

Published Date: 23 July 2015

Navigating into the binding pockets of the HER family protein kinases: discovery of novel EGFR inhibitor as antitumor agent

Liu W, Ning JF, Meng QW, Hu J, Zhao YB, Liu C, Cai L

Drug Design, Development and Therapy 2015, 9:3837-3851

Published Date: 23 July 2015

Effect of lactoferrin protein on red blood cells and macrophages: mechanism of parasite–host interaction

Anand N, Kanwar RK, Dubey ML, Vahishta RK, Sehgal R, Verma AK, Kanwar JR

Drug Design, Development and Therapy 2015, 9:3821-3835

Published Date: 27 July 2015

A new recombinant factor VIII: from genetics to clinical use

Kannicht C, Kohla G, Tiemeyer M, Walter O, Sandberg H

Drug Design, Development and Therapy 2015, 9:3817-3819

Published Date: 23 July 2015

Colon-targeted delivery of budesonide using dual pH- and time-dependent polymeric nanoparticles for colitis therapy

Naeem M, Choi MJ, Cao J, Lee Y, Ikram M, Yoon S, Lee J, Moon HR, Kim MS, Jung YJ, Yoo JW

Drug Design, Development and Therapy 2015, 9:3789-3799

Published Date: 21 July 2015

Design, development, drug-likeness, and molecular docking studies of novel piperidin-4-imine derivatives as antitubercular agents

Revathi R, Venkatesha Perumal R, Pai KSR, Arunkumar G, Sriram D, Kini SG

Drug Design, Development and Therapy 2015, 9:3779-3787

Published Date: 21 July 2015

Escherichia coli Nissle 1917 bacterial ghosts retain crucial surface properties and express chlamydial antigen: an imaging study of a delivery system for the ocular surface

Montanaro J, Inic-Kanada A, Ladurner A, Stein E, Belij S, Bintner N, Schlacher S, Schuerer N, Mayr UB, Lubitz W, Leisch N, Barisani-Asenbauer T

Drug Design, Development and Therapy 2015, 9:3741-3754

Published Date: 21 July 2015

Clinicopathological significance of matrix metalloproteinase-7 protein expression in esophageal cancer: a meta-analysis

Miao S, Zhou SY, Han CS, Zhang LN, Sun HB, Yang B

Drug Design, Development and Therapy 2015, 9:3729-3740

Published Date: 20 July 2015

Targeting brain cells with glutathione-modulated nanoliposomes: in vitro and in vivo study

Salem HF, Ahmed SM, Hassaballah AE, Omar MM

Drug Design, Development and Therapy 2015, 9:3705-3727

Published Date: 20 July 2015

Mechanisms underlying probucol-induced hERG-channel deficiency

Shi YQ, Yan CC, Zhang X, Yan M, Liu LR, Geng HZ, Lv L, Li BX

Drug Design, Development and Therapy 2015, 9:3695-3704

Published Date: 20 July 2015

Synthesis, antimicrobial and in vitro antitumor activities of a series of 1,2,3-thiadiazole and 1,2,3-selenadiazole derivatives

Mhaidat NM, Al-Smadi M, Al-Momani F, Alzoubi KH, Mansi I, Al-Balas Q

Drug Design, Development and Therapy 2015, 9:3645-3652

Published Date: 16 July 2015

2-acetylphenol analogs as potent reversible monoamine oxidase inhibitors

Legoabe LJ, Petzer A, Petzer JP

Drug Design, Development and Therapy 2015, 9:3635-3644

Published Date: 15 July 2015

Downregulation of miR203 induces overexpression of PIK3CA and predicts poor prognosis of gastric cancer patients

Liang M, Shi B, Liu J, He L, Yi G, Zhou L, Yu G, Zhou X

Drug Design, Development and Therapy 2015, 9:3607-3616

Published Date: 16 July 2015

Apparent Km of mitochondria for oxygen computed from Vmax measured in permeabilized muscle fibers is lower in water enriched in oxygen by electrolysis than injection

Zoll J, Bouitbir J, Sirvent P, Klein A, Charton A, Jimenez L, Péronnet FR, Geny B, Richard R

Drug Design, Development and Therapy 2015, 9:3589-3597

Published Date: 13 July 2015

Wound healing: a new perspective on glucosylated tetrahydrocurcumin

Bhaskar Rao A, Prasad E, Deepthi SS, Haritha V, Ramakrishna S, Madhusudan K, Surekha MV, Venkata Rao YSR

Drug Design, Development and Therapy 2015, 9:3579-3588

Published Date: 13 July 2015

Effect of Clausena excavata Burm. f. (Rutaceae) leaf extract on wound healing and antioxidant activity in rats

Albaayit SFA, Abba Y, Rasedee A, Abdullah N

Drug Design, Development and Therapy 2015, 9:3507-3518

Published Date: 13 July 2015

Phenolic indeno[1,2-b]indoles as ABCG2-selective potent and non-toxic inhibitors stimulating basal ATPase activity

Gozzi GJ, Bouaziz Z, Winter E, Daflon-Yunes N, Honorat M, Guragossian N, Marminon C, Valdameri G, Bollacke A, Guillon J, Pinaud N, Marchivie M, Cadena SM, Jose J, Le Borgne M, Di Pietro A

Drug Design, Development and Therapy 2015, 9:3481-3495

Published Date: 3 July 2015

Adaptive evolution and elucidating the potential inhibitor against schizophrenia to target DAOA (G72) isoforms

Sehgal SA, Mannan S, Kanwal S, Naveed I, Mir A

Drug Design, Development and Therapy 2015, 9:3471-3480

Published Date: 3 July 2015

Selective use of vandetanib in the treatment of thyroid cancer

Fallahi P, Di Bari F, Ferrari SM, Spisni R, Materazzi G, Miccoli P, Benvenga S, Antonelli A

Drug Design, Development and Therapy 2015, 9:3459-3470

Published Date: 3 July 2015

Animal models of ischemic stroke and their application in clinical research

Fluri F, Schuhmann MK, Kleinschnitz C

Drug Design, Development and Therapy 2015, 9:3445-3454

Published Date: 2 July 2015

Evaluation of the efficacy and safety of three dosing regimens of agalsidase alfa enzyme replacement therapy in adults with Fabry disease

Goláň L, Goker-Alpan O, Holida M, Kantola I, Klopotowski M, Kuusisto J, Linhart A, Musial J, Nicholls K, Gonzalez-Rodriguez D, Sharma R, Vujkovac B, Chang P, Wijatyk A

Drug Design, Development and Therapy 2015, 9:3435-3444

Published Date: 8 July 2015

Pharmacokinetics, pharmacodynamics, and safety of lesinurad, a selective uric acid reabsorption inhibitor, in healthy adult males

Shen Z, Rowlings C, Kerr B, Hingorani V, Manhard K, Quart B, Yeh LT, Storgard C

Drug Design, Development and Therapy 2015, 9:3423-3434

Published Date: 2 July 2015

Effect of vitamin C on inflammation and metabolic markers in hypertensive and/or diabetic obese adults: a randomized controlled trial

Ellulu MS, Rahmat A, Patimah I, Khaza’ai H, Abed Y

Drug Design, Development and Therapy 2015, 9:3405-3412

Published Date: 1 July 2015

Discovery of 3-n-butyl-2,3-dihydro-1H-isoindol-1-one as a potential anti-ischemic stroke agent

Lan Z, Xu X, Xu W, Li J, Liang Z, Zhang X, Lei M, Zhao C

Drug Design, Development and Therapy 2015, 9:3377-3391

Published Date: 30 June 2015

Dose-dependent effects of atorvastatin on myocardial infarction

Barbarash O, Gruzdeva O, Uchasova E, Belik E, Dyleva Y, Karetnikova V

Drug Design, Development and Therapy 2015, 9:3361-3368

Published Date: 29 June 2015

The role of Gliadel wafers in the treatment of newly diagnosed GBM: a meta-analysis

Xing WK, Shao C, Qi ZY, Yang C, Wang Z

Drug Design, Development and Therapy 2015, 9:3341-3348

Published Date: 29 June 2015

Enzalutamide for the treatment of metastatic castration-resistant prostate cancer

Rodriguez-Vida A, Galazi M, Rudman S, Chowdhury S, Sternberg CN

Drug Design, Development and Therapy 2015, 9:3325-3339

Published Date: 29 June 2015

Effect of renal impairment on the pharmacokinetics of levomilnacipran following a single oral dose of levomilnacipran extended-release capsule in humans

Chen L, Greenberg WM, Brand-Schieber E, Wangsa J, Periclou A, Ghahramani P

Drug Design, Development and Therapy 2015, 9:3293-3300

Published Date: 25 June 2015

Animal models of polymicrobial pneumonia

Hraiech S, Papazian L, Rolain JM, Bregeon F

Drug Design, Development and Therapy 2015, 9:3279-3292

Published Date: 26 June 2015

Development of biosimilars in an era of oncologic drug shortages

Li E, Subramanian J, Anderson S, Thomas D, McKinley J, Jacobs IA

Drug Design, Development and Therapy 2015, 9:3247-3255

Published Date: 24 June 2015

Sphingosine kinase 1 as an anticancer therapeutic target

Gao Y, Gao F, Chen K, Tian ML, Zhao DL

Drug Design, Development and Therapy 2015, 9:3239-3245

Published Date: 23 June 2015

Simvastatin prevents isoproterenol-induced cardiac hypertrophy through modulation of the JAK/STAT pathway

Al-Rasheed NM, Al-Oteibi MM, Al-Manee RZ, Al-Shareef SA, Al-Rasheed NM, Hasan IH, Mohamad RA, Mahmoud AM

Drug Design, Development and Therapy 2015, 9:3217-3229

Published Date: 23 June 2015

Disposition and metabolism of [14C]-levomilnacipran, a serotonin and norepinephrine reuptake inhibitor, in humans, monkeys, and rats

Brunner V, Maynadier B, Chen L, Roques L, Hude I, Séguier S, Barthe L, Hermann P

Drug Design, Development and Therapy 2015, 9:3199-3215

Published Date: 23 June 2015

Characterization of renal biomarkers for use in clinical trials: effect of preanalytical processing and qualification using samples from subjects with diabetes

Brott DA, Furlong ST, Adler SH, Hainer JW, Arani RB, Pinches M, Rossing P, Chaturvedi N

Drug Design, Development and Therapy 2015, 9:3191-3198

Published Date: 22 June 2015

The impact of lipocalin-type-prostaglandin-D-synthase as a predictor of kidney disease in patients with type 2 diabetes

Bacci MR, Cavallari MR, de Rozier-Alves RM, Alves BCA, Fonseca FLA

Drug Design, Development and Therapy 2015, 9:3179-3182

Published Date: 22 June 2015

Histone demethylase LSD1-mediated repression of GATA-2 is critical for erythroid differentiation

Guo Y, Fu X, Jin Y, Sun J, Liu Y, Huo B, Li X, Hu X

Drug Design, Development and Therapy 2015, 9:3153-3162

Published Date: 19 June 2015

Gamma scintigraphic study of the hydrodynamically balanced matrix tablets of Metformin HCl in rabbits

Razavi M, Karimian H, Yeong CH, Sarji SA, Chung LY, Nyamathulla S, Noordin MI

Drug Design, Development and Therapy 2015, 9:3125-3139

Published Date: 19 June 2015

Insulin administration: present strategies and future directions for a noninvasive (possibly more physiological) delivery

Matteucci E, Giampietro O, Covolan V, Giustarini D, Fanti P, Rossi R

Drug Design, Development and Therapy 2015, 9:3109-3118

Published Date: 17 June 2015

Phase II study of reintroduction of oxaliplatin for advanced colorectal cancer in patients previously treated with oxaliplatin and irinotecan: RE-OPEN study

Suenaga M, Mizunuma N, Matsusaka S, Shinozaki E, Ozaka M, Ogura M, Yamaguchi T

Drug Design, Development and Therapy 2015, 9:3099-3108

Published Date: 16 June 2015

Inhibition of cyclooxygenase-2 prevents intra-abdominal adhesions by decreasing activity of peritoneal fibroblasts

Wei G, Chen X, Wang G, Jia P, Xu Q, Ping G, Wang K, Li X

Drug Design, Development and Therapy 2015, 9:3083-3098

Published Date: 15 June 2015

Profile of evolocumab and its potential in the treatment of hyperlipidemia

Cicero AF, Colletti A, Borghi C

Drug Design, Development and Therapy 2015, 9:3073-3082

Published Date: 15 June 2015

Antibiotic-modifying activity of riachin, a non-cyanogenic cyanoglycoside extracted from Bauhinia pentandra

Farias PAM, Figueredo FG, Lucas AMB, Moura RB, Coutinho HDM, Silva TMS, Martin ALAR, Fonteles MMF

Drug Design, Development and Therapy 2015, 9:3067-3072

Published Date: 15 June 2015

Cardioprotection against ischemia/reperfusion injury by QiShenYiQi Pill® via ameliorate of multiple mitochondrial dysfunctions

Chen JR, Wei J, Wang LY, Zhu Y, Li L, Olunga MA, Gao XM, Fan GW

Drug Design, Development and Therapy 2015, 9:3051-3066

Published Date: 15 June 2015

Efficiency and safety of subconjunctival injection of anti-VEGF agent – bevacizumab – in treating dry eye

Jiang X, Lv H, Qiu W, Liu Z, Li X, Wang W

Drug Design, Development and Therapy 2015, 9:3043-3050

Published Date: 12 June 2015

Effect of database profile variation on drug safety assessment: an analysis of spontaneous adverse event reports of Japanese cases

Nomura K, Takahashi K, Hinomura Y, Kawaguchi G, Matsushita Y, Marui H, Anzai T, Hashiguchi M, Mochizuki M

Drug Design, Development and Therapy 2015, 9:3031-3041

Published Date: 12 June 2015

Oleanolic acid induces mitochondrial-dependent apoptosis and G0/G1 phase arrest in gallbladder cancer cells

Li HF, Wang XA, Xiang SS, Hu YP, Jiang L, Shu YJ, Li ML, Wu XS, Zhang F, Ye YY, Weng H, Bao RF, Cao Y, Lu W, Dong Q, Liu YB

Drug Design, Development and Therapy 2015, 9:3017-3030

Published Date: 12 June 2015

Osteopontin promotes dendritic cell maturation and function in response to HBV antigens

Cui GY, Chen JN, He JQ, Lu C, Wei YF, Wang L, Xu XJ, Li LJ, Uede T, Diao HY

Drug Design, Development and Therapy 2015, 9:3003-3016

Published Date: 12 June 2015

Involvement of NF-κB and HSP70 signaling pathways in the apoptosis of MDA-MB-231 cells induced by a prenylated xanthone compound, α-mangostin, from Cratoxylum arborescens [Corrigendum]

Ibrahim MY, Hashim NM, Mohan S, Abdulla MA, Abdelwahab SI, Kamalidehghan B, Ghaderian M, Dehghan F, Ali LZ, Karimian H, Yahayu M, Ee GCL, Farjam AS, Ali HM

Drug Design, Development and Therapy 2015, 9:3001-3002

Published Date: 12 June 2015

Assessment of hydroxychloroquine maculopathy after cessation of treatment: an optical coherence tomography and multifocal electroretinography study

Moschos MM, Nitoda E, Chatziralli IP, Gatzioufas Z, Koutsandrea C, Kitsos G

Drug Design, Development and Therapy 2015, 9:2993-2999

Published Date: 11 June 2015

Protective effect of galangin in Concanavalin A- induced hepatitis in mice

Luo Q, Zhu L, Ding J, Zhuang X, Xu L, Chen F

Drug Design, Development and Therapy 2015, 9:2983-2992

Published Date: 10 June 2015

Oxidant/antioxidant status, paraoxonase activity, and lipid profile in plasma of ovariectomized rats under the influence of estrogen, estrogen combined with progesterone, and genistein

Agacayak E, Basaranoglu S, Tunc SY, Icen MS, Findik FM, Kaplan I, Evliyaoglu O, Gul T

Drug Design, Development and Therapy 2015, 9:2975-2982

Published Date: 10 June 2015

Immunostimulatory effects of the standardized extract of Tinospora crispa on innate immune responses in Wistar Kyoto rats

Ahmad W, Jantan I, Kumolosasi E, Abbas Bukhari SN

Drug Design, Development and Therapy 2015, 9:2961-2973

Published Date: 10 June 2015

Cissus quadrangularis inhibits IL-1β induced inflammatory responses on chondrocytes and alleviates bone deterioration in osteotomized rats via p38 MAPK signaling

Kanwar JR, Samarasinghe RM, Kumar K, Arya R, Sharma S, Zhou SF, Sasidharan S, Kanwar RK

Drug Design, Development and Therapy 2015, 9:2927-2940

Published Date: 5 June 2015

Small-molecule BH3 mimetic and pan-Bcl-2 inhibitor AT-101 enhances the antitumor efficacy of cisplatin through inhibition of APE1 repair and redox activity in non-small-cell lung cancer

Ren T, Shan J, Li M, Qing Y, Qian C, Wang G, Li Q, Lu G, Li C, Peng Y, Luo H, Zhang S, Yang Y, Cheng Y, Wang D, Zhou SF

Drug Design, Development and Therapy 2015, 9:2887-2910

Published Date: 8 June 2015

Spotlight on pembrolizumab in the treatment of advanced melanoma

Rajakulendran T, Adam DN

Drug Design, Development and Therapy 2015, 9:2883-2886

Published Date: 4 June 2015

Protective effect of Huang Gan formula in 5/6 nephrectomized rats by depressing the Wnt/β-catenin signaling pathway

Mo LQ, Xiao XY, Song SL, Miao H, Liu ST, Guo D, Li X, Bu C, Hou LB, Yang XX

Drug Design, Development and Therapy 2015, 9:2867-2881

Published Date: 3 June 2015

Efficacy of fimasartan/hydrochlorothiazide combination in hypertensive patients inadequately controlled by fimasartan monotherapy

Rhee MY, Baek SH, Kim W, Park CG, Park SW, Oh BH, Kim SH, Kim JJ, Shin JH, Yoo BS, Rim SJ, Ha JW, Doh JH, Ahn Y, Chae JK, Park JB, Kim SK, Kim CH

Drug Design, Development and Therapy 2015, 9:2847-2854

Published Date: 2 June 2015

Cost-effectiveness analysis of lamivudine, telbivudine, and entecavir in treatment of chronic hepatitis B with adefovir dipivoxil resistance

Wang G, Liu Y, Qiu P, Zhou SF, Xu L, Wen P, Wen J, Xiao X

Drug Design, Development and Therapy 2015, 9:2839-2846

Published Date: 2 June 2015

Applications of calixarenes in cancer chemotherapy: facts and perspectives

Yousaf A, Abd Hamid S, Bunnori NM, Ishola AA

Drug Design, Development and Therapy 2015, 9:2831-2838

Published Date: 2 June 2015

Neuroprotective and antioxidant effects of ghrelin in an experimental glaucoma model

Can N, Catak O, Turgut B, Demir T, Ilhan N, Kuloglu T, Ozercan IH

Drug Design, Development and Therapy 2015, 9:2819-2829

Published Date: 2 June 2015

Itraconazole solid dispersion prepared by a supercritical fluid technique: preparation, in vitro characterization, and bioavailability in beagle dogs

Yin X, Daintree LS, Ding S, Ledger DM, Wang B, Zhao W, Qi J, Wu W

Drug Design, Development and Therapy 2015, 9:2801-2810

Published Date: 28 May 2015

Isolation and evaluation of anticancer efficacy of stigmasterol in a mouse model of DMBA-induced skin carcinoma

Ali H, Dixit S, Ali D, Alqahtani SM, Alkahtani S, Alarifi S

Drug Design, Development and Therapy 2015, 9:2793-2800

Published Date: 28 May 2015

Role of sodium tungstate as a potential antiplatelet agent

Fernández-Ruiz R, Pino M, Hurtado B, García de Frutos P, Caballo C, Escolar G, Gomis R, Diaz-Ricart M

Drug Design, Development and Therapy 2015, 9:2777-2786

Published Date: 26 May 2015

Combination therapy of fenofibrate and ursodeoxycholic acid in patients with primary biliary cirrhosis who respond incompletely to UDCA monotherapy: a meta-analysis

Zhang Y, Li S, He L, Wang F, Chen K, Li J, Liu T, Zheng Y, Wang J, Lu W, Zhou Y, Yin Q, Xia Y, Zhou Y, Lu J, Guo C

Drug Design, Development and Therapy 2015, 9:2757-2766

Published Date: 25 May 2015

Antitumor effects of traditional Chinese medicine targeting the cellular apoptotic pathway

Xu HL, Zhao X, Liu XH, Xu PX, Zhang KM, Lin XK

Drug Design, Development and Therapy 2015, 9:2735-2744

Published Date: 21 May 2015

Effects of strontium ranelate on bone formation in the mid-palatal suture after rapid maxillary expansion

Zhao SY, Wang XX, Li N, Chen Y, Su YR, Zhang J

Drug Design, Development and Therapy 2015, 9:2725-2734

Published Date: 21 May 2015

Synthesis and characterization of tumor-targeted copolymer nanocarrier modified by transferrin

Liu R, Wang Y, Li X, Bao W, Xia G, Chen W, Cheng J, Xu Y, Guo L, Chen B

Drug Design, Development and Therapy 2015, 9:2705-2719

Published Date: 22 May 2015

Anti-Warburg effect of rosmarinic acid via miR-155 in gastric cancer cells

Han S, Yang SH, Cai Z, Pan DY, Li Z, Huang ZH, Zhang PS, Zhu HJ, Lei LJ, Wang WW

Drug Design, Development and Therapy 2015, 9:2695-2703

Published Date: 19 May 2015

Impact of JAK2(V617F) mutation status on treatment response to anagrelide in essential thrombocythemia: an observational, hypothesis-generating study

Cascavilla N, De Stefano V, Pane F, Pancrazzi A, Iurlo A, Gobbi M, Palandri F, Specchia G, Liberati AM, D’Adda M, Gaidano G, Fjerza R, Achenbach H, Smith J, Wilde P, Vannucchi AM

Drug Design, Development and Therapy 2015, 9:2687-2694

Published Date: 18 May 2015

The usefulness of ozone treatment in spinal pain

Bocci V, Borrelli E, Zanardi I, Travagli V

Drug Design, Development and Therapy 2015, 9:2677-2685

Published Date: 15 May 2015

A thorough QT study to assess the effects of tbo-filgrastim on cardiac repolarization in healthy subjects

Adar L, Avisar N, Lammerich A, Kleiman RB, Spiegelstein O

Drug Design, Development and Therapy 2015, 9:2653-2662

Published Date: 15 May 2015

Construction of interference vector targeting Ep-CAM gene and its effects on colorectal cancer cell proliferation

Qi Y, Zhou F, Zhang L, Liu L, Xu H, Guo H

Drug Design, Development and Therapy 2015, 9:2647-2652

Published Date: 14 May 2015

A study on the hemocompatibility of dendronized chitosan derivatives in red blood cells

Zhou YF, Li JM, Lu F, Deng JJ, Zhang JH, Fang PJ, Peng XS, Zhou SF

Drug Design, Development and Therapy 2015, 9:2635-2645

Published Date: 14 May 2015

Prevalence of the CYP2D6*10 (C100T), *4 (G1846A), and *14 (G1758A) alleles among Iranians of different ethnicities

Bagheri A, Kamalidehghan B, Haghshenas M, Azadfar P, Akbari L, Sangtarash MH, Vejdandoust F, Ahmadipour F, Meng GY, Houshmand M

Drug Design, Development and Therapy 2015, 9:2627-2634

Published Date: 13 May 2015

A pharmacokinetic comparison of two voriconazole formulations and the effect of CYP2C19 polymorphism on their pharmacokinetic profiles

Chung H, Lee H, Han H, An H, Lim KS, Lee YJ, Cho JY, Yoon SH, Jang IJ, Yu KS

Drug Design, Development and Therapy 2015, 9:2609-2616

Published Date: 13 May 2015

Skin regeneration in deep second-degree scald injuries either by infusion pumping or topical application of recombinant human erythropoietin gel

Giri P, Ebert S, Braumann UD, Kremer M, Giri S, Machens HG, Bader A

Drug Design, Development and Therapy 2015, 9:2565-2579

Published Date: 11 May 2015

Aging-related rotenone-induced neurochemical and behavioral deficits: role of SIRT2 and redox imbalance, and neuroprotection by AK-7

Wang X, Guan Q, Wang M, Yang L, Bai J, Yan Z, Zhang Y, Liu Z

Drug Design, Development and Therapy 2015, 9:2553-2563

Published Date: 7 May 2015

The mazEF toxin–antitoxin system as an attractive target in clinical isolates of Enterococcus faecium and Enterococcus faecalis

Soheili S, Ghafourian S, Sekawi Z, Neela VK, Sadeghifard N, Taherikalani M, Khosravi A, Ramli R, Hamat RA

Drug Design, Development and Therapy 2015, 9:2553-2561

Published Date: 8 May 2015

Sonodynamic effect of hematoporphyrin monomethyl ether on ligature-induced periodontitis in rats

Zhuang DS, Han JL, Bi LJ, Wang YP, Hao YR, Zhou Q, Cao WW

Drug Design, Development and Therapy 2015, 9:2545-2551

Published Date: 6 May 2015

A prospective treatment for sepsis

Shahidi Bonjar MR, Shahidi Bonjar L

Drug Design, Development and Therapy 2015, 9:2537-2543

Published Date: 6 May 2015

Efficacy and safety of different doses of a slow-release corticosteroid implant for macular edema: meta-analysis of randomized controlled trials

Liu QY, He MM, Shi H, Wang QY, Du YR, Liu JL, Ren CD, Xu D, Yu J

Drug Design, Development and Therapy 2015, 9:2527-2535

Published Date: 5 May 2015

Preparation and characterization of genipin-cross-linked silk fibroin/chitosan sustained-release microspheres

Zeng SG, Ye MW, Qiu JQ, Fang W, Rong MD, Guo ZH, Gao WF

Drug Design, Development and Therapy 2015, 9:2501-2514

Published Date: 4 May 2015

Body protective compound-157 enhances alkali-burn wound healing in vivo and promotes proliferation, migration, and angiogenesis in vitro

Huang T, Zhang K, Sun L, Xue X, Zhang C, Shu Z, Mu N, Gu J, Zhang W, Wang Y, Zhang Y, Zhang W

Drug Design, Development and Therapy 2015, 9:2485-2499

Published Date: 30 April 2015

Enhanced anti-inflammatory potential of cinnamate-zinc layered hydroxide in lipopolysaccharide-stimulated RAW 264.7 macrophages

Adewoyin M, Mohsin SMN, Arulselvan P, Hussein MZ, Fakurazi S

Drug Design, Development and Therapy 2015, 9:2475-2484

Published Date: 30 April 2015

Preparation and clinical evaluation of nano-transferosomes for treatment of erectile dysfunction

Ali MFM, Salem HF, Abdelmohsen HF, Attia SK

Drug Design, Development and Therapy 2015, 9:2431-2447

Published Date: 29 April 2015

Pharmacokinetics of mitragynine in man

Trakulsrichai S, Sathirakul K, Auparakkitanon S, Krongvorakul J, Sueajai J, Noumjad N, Sukasem C, Wananukul W

Drug Design, Development and Therapy 2015, 9:2421-2429

Published Date: 29 April 2015

Ultrasound contrast agent loaded with nitric oxide as a theranostic microdevice

Grishenkov D, Gonon A, Weitzberg E, Lundberg JO, Harmark J, Cerroni B, Paradossi G, Janerot-Sjoberg B

Drug Design, Development and Therapy 2015, 9:2409-2419

Published Date: 29 April 2015

Wnt blockers inhibit the proliferation of lung cancer stem cells

Zhang X, Lou Y, Zheng X, Wang H, Sun J, Dong Q, Han B

Drug Design, Development and Therapy 2015, 9:2399-2407

Published Date: 28 April 2015

Development of acquired factor V inhibitor after treatment with ceftazidime: a case report and review of the literature

Cui QY, Shen HS, Wu TQ, Chen HF, Yu ZQ, Wang ZY

Drug Design, Development and Therapy 2015, 9:2395-2398

Published Date: 24 April 2015

Structure–activity exploration of a small-molecule Lipid II inhibitor

Fletcher S, Yu W, Huang J, Kwasny SM, Chauhan J, Opperman TJ, MacKerell Jr AD, de Leeuw EPH

Drug Design, Development and Therapy 2015, 9:2383-2394

Published Date: 24 April 2015

Comparative fasting bioavailability of two clopidogrel formulations in healthy Mediterranean volunteers: an in vitro–in vivo correlation

Zaid AN, Al Ramahi R, Bustami R, Mousa A, Khasawneh S

Drug Design, Development and Therapy 2015, 9:2359-2365

Published Date: 24 April 2015

Critical appraisal of bevacizumab in the treatment of ovarian cancer

Yoshida H, Yabuno A, Fujiwara K

Drug Design, Development and Therapy 2015, 9:2351-2358

Published Date: 28 April 2015

Modifying tetramethyl–nitrophenyl–imidazoline with amino acids: design, synthesis, and 3D-QSAR for improving inflammatory pain therapy

Jiang X, Wang Y, Zhu H, Wang Y, Zhao M, Zhao S, Wu J, Li S, Peng S

Drug Design, Development and Therapy 2015, 9:2329-2342

Published Date: 22 April 2015

A novel glycyrrhetinic acid-modified oxaliplatin liposome for liver-targeting and in vitro/vivo evaluation

Chen J, Jiang H, Wu Y, Li Y, Gao Y

Drug Design, Development and Therapy 2015, 9:2265-2275

Published Date: 20 April 2015

HDACiDB: a database for histone deacetylase inhibitors

Murugan K, Sangeetha S, Ranjitha S, Vimala A, Al-Sohaibani S, Rameshkumar G

Drug Design, Development and Therapy 2015, 9:2257-2264

Published Date: 20 April 2015

Anticancer activity of streptochlorin, a novel antineoplastic agent, in cholangiocarcinoma

Kwak TW, Shin HJ, Jeong YI, Han ME, Oh SO, Kim HJ, Kim DH, Kang DH

Drug Design, Development and Therapy 2015, 9:2201-2214

Published Date: 16 April 2015

Nanoparticle albumin-bound paclitaxel (nab-paclitaxel) as second-line chemotherapy in HER2-negative, taxane-pretreated metastatic breast cancer patients: prospective evaluation of activity, safety, and quality of life

Palumbo R, Sottotetti F, Trifirò G, Piazza E, Ferzi A, Gambaro A, Spinapolice EG, Pozzi E, Tagliaferri B, Teragni C, Bernardo A

Drug Design, Development and Therapy 2015, 9:2189-2199

Published Date: 15 April 2015

Evaluation of combined famotidine with quercetin for the treatment of peptic ulcer: in vivo animal study

Abourehab MA, Khaled KA, Sarhan HA, Ahmed OA

Drug Design, Development and Therapy 2015, 9:2159-2169

Published Date: 13 April 2015

The clinicopathological significance of CDH1 in gastric cancer: a meta-analysis and systematic review

Zeng W, Zhu J, Shan L, Han Z, Aerxiding P, Quhai A, Zeng F, Wang Z, Li H

Drug Design, Development and Therapy 2015, 9:2149-2157

Published Date: 13 April 2015

Paclitaxel attenuates renal interstitial fibroblast activation and interstitial fibrosis by inhibiting STAT3 signaling

Zhang L, Xu X, Yang R, Chen J, Wang S, Yang JQ, Xiang X, He Z, Zhao Y, Dong Z, Zhang D

Drug Design, Development and Therapy 2015, 9:2139-2148

Published Date: 15 April 2015

D-cycloserine augmentation in behavioral therapy for obsessive-compulsive disorder: a meta-analysis

Xia J, Du Y, Han J, Liu G, Wang X

Drug Design, Development and Therapy 2015, 9:2101-2117

Published Date: 21 April 2015

Management of severe sepsis: advances, challenges, and current status

Martin-Loeches I, Levy MM, Artigas A

Drug Design, Development and Therapy 2015, 9:2079-2088

Published Date: 9 April 2015

Impact of potential inappropriate NSAIDs use in chronic pain

Ussai S, Miceli L, Pisa FE, Bednarova R, Giordano A, Della Rocca G, Petelin R

Drug Design, Development and Therapy 2015, 9:2073-2077

Published Date: 9 April 2015

Efficacy and safety of cross-linked hyaluronic acid single injection on osteoarthritis of the knee: a post-marketing phase IV study

Bashaireh K, Naser Z, Hawadya KA, Sorour S, Al-Khateeb RN

Drug Design, Development and Therapy 2015, 9:2063-2072

Published Date: 8 April 2015

Quinoline-based clioquinol and nitroxoline exhibit anticancer activity inducing FoxM1 inhibition in cholangiocarcinoma cells

Chan-on W, Huyen NTB, Songtawee N, Suwanjang W, Prachayasittikul S, Prachayasittikul V

Drug Design, Development and Therapy 2015, 9:2033-2047

Published Date: 8 April 2015

Targeting the hypoxia pathway to treat pancreatic cancer

Erickson LA, Highsmith Jr WE, Fei P, Zhang J

Drug Design, Development and Therapy 2015, 9:2029-2031

Published Date: 8 April 2015

Schisandrin B inhibits cell growth and induces cellular apoptosis and autophagy in mouse hepatocytes and macrophages: implications for its hepatotoxicity

Zhang Y, Zhou ZW, Jin H, Hu C, He ZX, Yu ZL, Ko KM, Yang T, Zhang X, Pan SY, Zhou SF

Drug Design, Development and Therapy 2015, 9:2001-2027

Published Date: 9 April 2015

The effects of amlodipine and platelet rich plasma on bone healing in rats

Atalay Y, Bozkurt MF, Gonul Y, Cakmak O, Agacayak KS, Köse I, Hazman O, Keles H, Turamanlar O, Eroglu M

Drug Design, Development and Therapy 2015, 9:1973-1981

Published Date: 7 April 2015

Gelatin nanoparticle-mediated intranasal delivery of substance P protects against 6-hydroxydopamine-induced apoptosis: an in vitro and in vivo study

Lu CT, Jin RR, Jiang YN, Lin Q, Yu WZ, Mao KL, Tian FR, Zhao YP, zhao YZ

Drug Design, Development and Therapy 2015, 9:1955-1962

Published Date: 7 April 2015

Impact of enzyme replacement therapy and hematopoietic stem cell transplantation in patients with Morquio A syndrome

Tomatsu S, Sawamoto K, Alméciga-Díaz CJ, Shimada T, Bober MB, Chinen Y, Yabe H, Montaño AM, Giugliani R, Kubaski F, Yasuda E, Rodríguez-López A, Espejo-Mojica AJ, Sánchez OF, Mason RW, Barrera LA, Mackenzie WG, Orii T

Drug Design, Development and Therapy 2015, 9:1937-1953

Published Date: 1 April 2015

Comparative efficacy, acceptability, and tolerability of lisdexamfetamine in child and adolescent ADHD: a meta-analysis of randomized, controlled trials

Maneeton B, Maneeton N, Likhitsathian S, Suttajit S, Narkpongphun A, Srisurapanont M, Woottiluk P

Drug Design, Development and Therapy 2015, 9:1927-1936

Published Date: 1 April 2015

Clinical and pharmacological properties of incobotulinumtoxinA and its use in neurological disorders

Jost WH, Benecke R, Hauschke D, Jankovic J, Kaňovský P, Roggenkämper P, Simpson DM, Comella CL

Drug Design, Development and Therapy 2015, 9:1913-1926

Published Date: 1 April 2015

Liraglutide and obesity: a review of the data so far

Ladenheim EE

Drug Design, Development and Therapy 2015, 9:1867-1875

Published Date: 30 March 2015

Pharmacoinformatics approach for investigation of alternative potential hepatitis C virus nonstructural protein 5B inhibitors

Mirza MU, Ghori NUH, Ikram N, Adil AR, Manzoor S

Drug Design, Development and Therapy 2015, 9:1825-1841

Published Date: 27 March 2015

Paracellular permeation-enhancing effect of AT1002 C-terminal amidation in nasal delivery

Song KH, Kim SB, Shim CK, Chung SJ, Kim DD, Rhee SK, Choi GJ, Kim CH, Kim K

Drug Design, Development and Therapy 2015, 9:1815-1823

Published Date: 27 March 2015

Novel nanoliposomal delivery system for polydatin: preparation, characterization, and in vivo evaluation

Wang X, Guan Q, Chen W, Hu X, Li L

Drug Design, Development and Therapy 2015, 9:1805-1813

Published Date: 30 March 2015

Clinical significance of DAPK promoter hypermethylation in lung cancer: a meta-analysis

Li Y, Zhu M, Zhang X, Cheng D, Ma X

Drug Design, Development and Therapy 2015, 9:1785-1796

Published Date: 24 March 2015

Lost expression of ADAMTS5 protein associates with progression and poor prognosis of hepatocellular carcinoma

Li C, Xiong Y, Yang X, Wang L, Zhang S, Dai N, Li M, Ren T, Yang Y, Zhou SF, Gan L, Wang D

Drug Design, Development and Therapy 2015, 9:1773-1783

Published Date: 24 March 2015

Design and prediction of new anticoagulants as a selective Factor IXa inhibitor via three-dimensional quantitative structure-property relationships of amidinobenzothiophene derivatives

Gao JS, Tong XP, Chang YQ, He YX, Mei YD, Tan PH, Guo JL, Liao GC, Xiao GK, Chen WM, Zhou SF, Sun PH

Drug Design, Development and Therapy 2015, 9:1743-1759

Published Date: 23 March 2015

Single and multiple dose pharmacokinetics and tolerability of HX-1171, a novel antioxidant, in healthy volunteers

Kim YH, Choi HY, Lee SH, Lim HS, Miki T, Kang JK, Han KG, Bae KS

Drug Design, Development and Therapy 2015, 9:1735-1742

Published Date: 23 March 2015

Glu-Trp-ONa or its acylated analogue (R-Glu-Trp-ONa) administration enhances the wound healing in the model of chronic skin wounds in rabbits

Shevtsov MA, Smagina LV, Kudriavtceva TA, Petlenko SV, Voronkina IV

Drug Design, Development and Therapy 2015, 9:1717-1727

Published Date: 20 March 2015

Human colon carcinogenesis is associated with increased interleukin-17-driven inflammatory responses

Xie Z, Qu Y, Leng Y, Sun W, Ma S, Wei J, Hu J, Zhang X

Drug Design, Development and Therapy 2015, 9:1679-1689

Published Date: 18 March 2015

Synthesis and biological evaluation of a novel class of curcumin analogs as anti-inflammatory agents for prevention and treatment of sepsis in mouse model

Zhao C, Zhang Y, Zou P, Wang J, He W, Shi D, Li H, Liang G, Yang S

Drug Design, Development and Therapy 2015, 9:1663-1678

Published Date: 18 March 2015

A phase I/II study of biweekly capecitabine and irinotecan plus bevacizumab as second-line chemotherapy in patients with metastatic colorectal cancer

Suenaga M, Mizunuma N, Matsusaka S, Shinozaki E, Ozaka M, Ogura M, Chin K, Yamaguchi T

Drug Design, Development and Therapy 2015, 9:1653-1662

Published Date: 16 March 2015

Plumbagin induces G2/M arrest, apoptosis, and autophagy via p38 MAPK- and PI3K/Akt/mTOR-mediated pathways in human tongue squamous cell carcinoma cells

Pan ST, Qin Y, Zhou ZW, He ZX, Zhang X, Yang T, Yang YX, Wang D, Qiu JX, Zhou SF

Drug Design, Development and Therapy 2015, 9:1601-1626

Published Date: 16 March 2015

The application of click chemistry in the synthesis of agents with anticancer activity

Ma N, Wang Y, Zhao BX, Ye WC, Jiang S

Drug Design, Development and Therapy 2015, 9:1585-1599

Published Date: 12 March 2015

Induction of apoptosis and autophagy via sirtuin1- and PI3K/Akt/mTOR-mediated pathways by plumbagin in human prostate cancer cells

Zhou ZW, Li XX, He ZX, Pan ST, Yang Y, Zhang X, Chow K, Yang T, Qiu JX, Zhou Q, Tan J, Wang D, Zhou SF

Drug Design, Development and Therapy 2015, 9:1511-1554

Published Date: 12 March 2015

Effect of a topical copper indomethacin gel on inflammatory parameters in a rat model of osteoarthritis

Yassin NZ, El-Shenawy SM, Abdel-Rahman RF, Yakoot M, Hassan M, Helmy S

Drug Design, Development and Therapy 2015, 9:1491-1498

Published Date: 12 March 2015

Positive effects on hematological and biochemical imbalances in patients with metastatic breast cancer stage IV, of BP-C1, a new anticancer substance

Lindkær-Jensen S, Larsen S, Habib-Lindkær-Jensen N, Fagertun HE

Drug Design, Development and Therapy 2015, 9:1481-1490

Published Date: 13 March 2015

Neuroprotective therapies for glaucoma

Song W, Huang P, Zhang C

Drug Design, Development and Therapy 2015, 9:1469-1479

Published Date: 11 March 2015

Design, synthesis, and antifungal activities of novel triazole derivatives containing the benzyl group

Xu K, Huang L, Xu Z, Wang Y, Bai G, Wu Q, Wang X, Yu S, Jiang Y

Drug Design, Development and Therapy 2015, 9:1459-1467

Published Date: 11 March 2015

Cryo-ablation improves anti-tumor immunity through recovering tumor educated dendritic cells in tumor-draining lymph nodes

He XZ, Wang QF, Han S, Wang HQ, Ye YY, Zhu ZY, Zhang SZ

Drug Design, Development and Therapy 2015, 9:1449-1458

Published Date: 10 March 2015

Improved corneal bioavailability of ofloxacin: biodegradable microsphere-loaded ion-activated in situ gel delivery system

Sayed EG, Hussein AK, Khaled KA, Ahmed OAA

Drug Design, Development and Therapy 2015, 9:1427-1435

Published Date: 10 March 2015

Single dose pharmacokinetics of the novel transdermal donepezil patch in healthy volunteers

Kim YH, Choi HY, Lim HS, Lee SH, Jeon HS, Hong D, Kim SS, Choi YK, Bae KS

Drug Design, Development and Therapy 2015, 9:1419-1426

Published Date: 10 March 2015

In vivo antitumor and antimetastatic effects of flavokawain B in 4T1 breast cancer cell-challenged mice

Abu N, Mohamad NE, Yeap SK, Lim KL, Akhtar MN, Zulfadli AJ, Beh BK, Abdullah MP, Omar AR, Alitheen NB

Drug Design, Development and Therapy 2015, 9:1401-1417

Published Date: 6 March 2015

Development and optimization of carvedilol orodispersible tablets: enhancement of pharmacokinetic parameters in rabbits

Aljimaee YH, El-Helw AM, Ahmed OA, El-Say KM

Drug Design, Development and Therapy 2015, 9:1379-1392

Published Date: 5 March 2015

Evaluation of cationic polyamidoamine dendrimers’ dermal toxicity in the rat skin model

Winnicka K, Wroblewska M, Sosnowska K, Car H, Kasacka I

Drug Design, Development and Therapy 2015, 9:1367-1377

Published Date: 5 March 2015

Development and in vitro characterization of drug delivery system of rifapentine for osteoarticular tuberculosis

Wu J, Zuo Y, Hu YJ, Wang J, Li JD, Qiao B, Jiang DM

Drug Design, Development and Therapy 2015, 9:1359-1366

Published Date: 5 March 2015

Clinicopathological significance of CXCR4 in non-small cell lung cancer

Zhou X, He L, Hou G, Jiang B, Wang Y, Zhao L

Drug Design, Development and Therapy 2015, 9:1349-1358

Published Date: 5 March 2015

The effect of ethanol sclerotherapy of 5 minutes duration on cyst diameter and rat ovarian tissue in simple ovarian cysts

Şimşek M, Kuloğlu T, Pala Ş, Boztosun A, Can B, Atilgan R

Drug Design, Development and Therapy 2015, 9:1341-1347

Published Date: 5 March 2015

Profile of atacicept and its potential in the treatment of systemic lupus erythematosus

Cogollo E, Silva MA, Isenberg D

Drug Design, Development and Therapy 2015, 9:1331-1339

Published Date: 5 March 2015

Antitumor activity of SA12, a novel peptide, on SKBr-3 breast cancer cells via the mitochondrial apoptosis pathway

Yang L, Cui Y, Shen J, Lin F, Wang X, Long M, Wei J, Zhang H

Drug Design, Development and Therapy 2015, 9:1319-1330

Published Date: 2 March 2015

In vitro and in vivo anti-angiogenic activity of girinimbine isolated from Murraya koenigii

Iman V, Karimian H, Mohan S, Hobani YH, Noordin MI, Mustafa MR, Noor SM

Drug Design, Development and Therapy 2015, 9:1281-1292

Published Date: 3 March 2015

Antitumoral materials with regenerative function obtained using a layer-by-layer technique

Ficai D, Sonmez M, Albu MG, Mihaiescu DE, Ficai A, Bleotu C

Drug Design, Development and Therapy 2015, 9:1269-1279

Published Date: 2 March 2015

Noncoding RNAs as potential biomarkers to predict the outcome in pancreatic cancer

Jin K, Luo G, Xiao Z, Liu Z, Liu C, Ji S, Xu J, Liu L, Long J, Ni Q, Yu X

Drug Design, Development and Therapy 2015, 9:1247-1255

Published Date: 26 February 2015

Pharmacokinetic-pharmacodynamic analysis to evaluate the effect of moxifloxacin on QT interval prolongation in healthy Korean male subjects

Hong T, Han S, Lee J, Jeon S, Park GJ, Park WS, Lim KS, Chung JY, Yu KS, Yim DS

Drug Design, Development and Therapy 2015, 9:1233-1245

Published Date: 26 February 2015

Advantageous effects of immunosuppression with tacrolimus in comparison with cyclosporine A regarding renal function in patients after heart transplantation

Helmschrott M, Rivinius R, Ruhparwar A, Schmack B, Erbel C, Gleissner CA, Akhavanpoor M, Frankenstein L, Ehlermann P, Bruckner T, Katus HA, Doesch AO

Drug Design, Development and Therapy 2015, 9:1217-1224

Published Date: 24 February 2015

Pharmacokinetic interaction between udenafil and dapoxetine: a randomized, open-labeled crossover study in healthy male volunteers

Kim YH, Choi HY, Lee SH, Jeon HS, Lim HS, Bahng MY, Bae KS

Drug Design, Development and Therapy 2015, 9:1209-1216

Published Date: 23 February 2015

Koenimbin, a natural dietary compound of Murraya koenigii (L) Spreng: inhibition of MCF7 breast cancer cells and targeting of derived MCF7 breast cancer stem cells (CD44+/CD24-/low): an in vitro study

Ahmadipour F, Noordin MI, Mohan S, Arya A, Paydar M, Looi CY, Keong YS, Siyamak EN, Fani S, Firoozi M, Yong CL, Sukari MA, Kamalidehghan B

Drug Design, Development and Therapy 2015, 9:1193-1208

Published Date: 24 February 2015

The pan-inhibitor of Aurora kinases danusertib induces apoptosis and autophagy and suppresses epithelial-to-mesenchymal transition in human breast cancer cells

Li JP, Yang YX, Liu QL, Zhou ZW, Pan ST, He ZX, Zhang X, Yang T, Pan SY, Duan W, He SM, Chen XW, Qiu JX, Zhou SF

Drug Design, Development and Therapy 2015, 9:1027-1062

Published Date: 17 February 2015

Bardoxolone methyl induces apoptosis and autophagy and inhibits epithelial-to-mesenchymal transition and stemness in esophageal squamous cancer cells

Wang YY, Yang YX, Zhao R, Pan ST, Zhe H, He ZX, Duan W, Zhang X, Yang TX, Qiu JX, Zhou SF

Drug Design, Development and Therapy 2015, 9:993-1026

Published Date: 17 February 2015

Synthesis of an anthraquinone derivative (DHAQC) and its effect on induction of G2/M arrest and apoptosis in breast cancer MCF-7 cell line

Yeap SK, Akhtar MN, Lim KL, Abu N, Ho WY, Zareen S, Roohani K, Ky H, Tan SW, Lajis N, Alitheen NB

Drug Design, Development and Therapy 2015, 9:983-992

Published Date: 17 February 2015

1-1-12 one-step wash-in scheme for desflurane low flow anesthesia: performance without nitrous oxide

Sathitkarnmanee T, Tribuddharat S, Nonlhaopol D, Thananun M, Somdee W

Drug Design, Development and Therapy 2015, 9:977-981

Published Date: 17 February 2015

Human mesenchymal stem cells as delivery of osteoprotegerin gene: homing and therapeutic effect for osteosarcoma

Qiao B, Shui W, Cai L, Guo SQ, Jiang DM

Drug Design, Development and Therapy 2015, 9:969-976

Published Date: 17 February 2015

Design, synthesis, and computational studies on dihydropyrimidine scaffolds as potential lipoxygenase inhibitors and cancer chemopreventive agents

Venugopala KN, Govender R, Khedr MA, Venugopala R, Aldhubiab BE, Harsha S, Odhav B

Drug Design, Development and Therapy 2015, 9:911-921

Published Date: 17 February 2015

Upregulation of PD-L1 and APE1 is associated with tumorigenesis and poor prognosis of gastric cancer

Qing Y, Li Q, Ren T, Xia W, Peng Y, Liu GL, Luo H, Yang YX, Dai XY, Zhou SF, Wang D

Drug Design, Development and Therapy 2015, 9:901-909

Published Date: 16 February 2015

Treatment with a herbal formula B401 enhances neuroprotection and angiogenesis in the R6/2 mouse model of Huntington’s disease

Wang SE, Lin CL, Hsu CH, Sheu SJ, Chien CT, Wu CH

Drug Design, Development and Therapy 2015, 9:887-900

Published Date: 16 February 2015

Tazarotene as alternative topical treatment for onychomycosis

Campione E, Paternò EJ, Costanza G, Diluvio L, Carboni I, Marino D, Favalli C, Chimenti S, Bianchi L, Orlandi A

Drug Design, Development and Therapy 2015, 9:879-886

Published Date: 16 February 2015

Anesthetic drug midazolam inhibits cardiac human ether-à-go-go-related gene channels: mode of action

Vonderlin N, Fischer F, Zitron E, Seyler C, Scherer D, Thomas D, Katus HA, Scholz EP,

Drug Design, Development and Therapy 2015, 9:867-877

Published Date: 16 February 2015

Recent advances in combinatorial biosynthesis for drug discovery

Sun H, Liu Z, Zhao H, Ang EL

Drug Design, Development and Therapy 2015, 9:823-833

Published Date: 12 February 2015

Development of a test for recording both visual and auditory reaction times, potentially useful for future studies in patients on opioids therapy

Miceli L, Bednarova R, Rizzardo A, Samogin V, Della Rocca G

Drug Design, Development and Therapy 2015, 9:817-822

Published Date: 12 February 2015

Borreliacidal activity of Borrelia metal transporter A (BmtA) binding small molecules by manganese transport inhibition

Wagh D, Pothineni VR, Inayathullah M, Liu S, Kim KM, Rajadas J

Drug Design, Development and Therapy 2015, 9:805-816

Published Date: 10 February 2015

Clinical utility of eslicarbazepine: current evidence

Zaccara G, Giovannelli F, Cincotta M, Carelli A, Verrotti A

Drug Design, Development and Therapy 2015, 9:781-789

Published Date: 10 February 2015

Effect and mechanism of fluoxetine on electrophysiology in vivo in a rat model of postmyocardial infarction depression

Liang J, Yuan X, Shi S, Wang F, Chen Y, Qu C, Chen J, Hu D, Yang B

Drug Design, Development and Therapy 2015, 9:763-772

Published Date: 10 February 2015

Clinical pharmacokinetics of AZD3199, an inhaled ultra-long-acting β2-adrenoreceptor agonist (uLABA)

Bjermer L, Kuna P, Jorup C, Bengtsson T, Rosenborg J

Drug Design, Development and Therapy 2015, 9:753-762

Published Date: 5 February 2015

A pharmacokinetic and pharmacodynamic drug interaction between rosuvastatin and valsartan in healthy subjects

Jung JA, Lee SY, Kim JR, Ko JW, Jang SB, Nam SY, Huh W

Drug Design, Development and Therapy 2015, 9:745-752

Published Date: 2 March 2015

Urine metabolomics in rats after administration of ketamine

Wen C, Zhang M, Ma J, Hu L, Wang X, Lin G

Drug Design, Development and Therapy 2015, 9:717-722

Published Date: 3 February 2015

Steroid for epidural injection in spinal stenosis: a systematic review and meta-analysis

Liu K, Liu PC, Liu R, Wu X, Cai M

Drug Design, Development and Therapy 2015, 9:707-716

Published Date: 30 January 2015

Design and in vivo evaluation of oxycodone once-a-day controlled-release tablets

Kim JY, Lee SH, Park CW, Rhee YS, Kim DW, Park J, Lee M, Seo JW, Park ES

Drug Design, Development and Therapy 2015, 9:695-706

Published Date: 30 January 2015

Profile of delamanid for the treatment of multidrug-resistant tuberculosis

Szumowski JD, Lynch JB

Drug Design, Development and Therapy 2015, 9:677-682

Published Date: 29 January 2015

Apparent histological changes of adipocytes after treatment with CL 316,243, a ß-3-adrenergic receptor agonist

Ghorbani M, Teimourian S, Farzad R, Asl NN

Drug Design, Development and Therapy 2015, 9:669-676

Published Date: 11 February 2015

Antiaging therapy: a prospective hypothesis

Shahidi Bonjar MR, Shahidi Bonjar L

Drug Design, Development and Therapy 2015, 9:663-667

Published Date: 28 January 2015

Organic anion transporter 3- and organic anion transporting polypeptides 1B1- and 1B3-mediated transport of catalposide

Jeong HU, Kwon M, Lee Y, Yoo JS, Shin DH, Song IS, Lee HS

Drug Design, Development and Therapy 2015, 9:643-653

Published Date: 22 January 2015

Alisertib induces cell cycle arrest and autophagy and suppresses epithelial-to-mesenchymal transition involving PI3K/Akt/mTOR and sirtuin 1-mediated signaling pathways in human pancreatic cancer cells

Wang F, Li H, Yan XG, Zhou ZW, Yi ZG, He ZX, Pan ST, Yang YX, Wang ZZ, Zhang X, Yang T, Qiu JX, Zhou SF

Drug Design, Development and Therapy 2015, 9:575-601

Published Date: 17 January 2015

Combination therapy of ursodeoxycholic acid and budesonide for PBC–AIH overlap syndrome: a meta-analysis

Zhang H, Yang J, Zhu R, Zheng Y, Zhou Y, Dai W, Wang F, Chen K, Li J, Wang C, Li S, Liu T, Abudumijiti H, Zhou Z, Wang J, Lu W, Wang J, Xia Y, Zhou Y, Lu J, Guo C

Drug Design, Development and Therapy 2015, 9:567-574

Published Date: 17 January 2015

Plumbagin induces cell cycle arrest and autophagy and suppresses epithelial to mesenchymal transition involving PI3K/Akt/mTOR-mediated pathway in human pancreatic cancer cells

Wang F, Wang Q, Zhou ZW, Yu SN, Pan ST, He ZX, Zhang X, Wang D, Yang YX, Yang T, Sun T, Li M, Qiu JX, Zhou SF

Drug Design, Development and Therapy 2015, 9:537-560

Published Date: 17 January 2015

Rare sugar D-psicose prevents progression and development of diabetes in T2DM model Otsuka Long-Evans Tokushima Fatty rats

Hossain A, Yamaguchi F, Hirose K, Matsunaga T, Sui L, Hirata Y, Noguchi C, Katagi A, Kamitori K, Dong Y, Tsukamoto I, Tokuda M

Drug Design, Development and Therapy 2015, 9:525-535

Published Date: 17 January 2015

HMG-CoA reductase inhibitory activity and phytocomponent investigation of Basella alba leaf extract as a treatment for hypercholesterolemia

Baskaran G, Salvamani S, Ahmad SA, Shaharuddin NA, Pattiram PD, Shukor MY

Drug Design, Development and Therapy 2015, 9:509-517

Published Date: 14 January 2015

Inhibition of mitotic Aurora kinase A by alisertib induces apoptosis and autophagy of human gastric cancer AGS and NCI-N78 cells

Yuan CX, Zhou ZW, Yang YX, He ZX, Zhang X, Wang D, Yang T, Wang NJ, Zhao RJ, Zhou SF

Drug Design, Development and Therapy 2015, 9:487-508

Published Date: 14 January 2015

Alisertib, an Aurora kinase A inhibitor, induces apoptosis and autophagy but inhibits epithelial to mesenchymal transition in human epithelial ovarian cancer cells

Ding YH, Zhou ZW, Ha CF, Zhang XY, Pan ST, He ZX, Edelman JL, Wang D, Yang ZX, Zhang XJ, Duan W, Yang TX, Qiu JX, Zhou SF

Drug Design, Development and Therapy 2015, 9:425-464

Published Date: 9 January 2015

Solid lipid nanoparticles loaded with iron to overcome barriers for treatment of iron deficiency anemia

Hosny KM, Banjar ZM, Hariri AH, Hassan AH

Drug Design, Development and Therapy 2015, 9:313-320

Published Date: 8 January 2015

Sample sizes in dosage investigational clinical trials: a systematic evaluation

Huang JH, Su QM, Yang J, Lv YH, He YC, Chen JC, Xu L, Wang K, Zheng QS

Drug Design, Development and Therapy 2015, 9:305-312

Published Date: 7 January 2015

Vipegitide: a folded peptidomimetic partial antagonist of α2β1 integrin with antiplatelet aggregation activity

Momic T, Katzhendler J, Shai E, Noy E, Senderowitz H, Eble JA, Marcinkiewicz C, Varon D, Lazarovici P

Drug Design, Development and Therapy 2015, 9:291-304

Published Date: 5 January 2015

Nanoparticle formulation by Büchi B-90 Nano Spray Dryer for oral mucoadhesion

Harsha SN, Aldhubiab BE, Nair AB, Alhaider IA, Attimarad M, Venugopala KN, Srinivasan S, Gangadhar N, Asif AH

Drug Design, Development and Therapy 2015, 9:273-282

Published Date: 23 January 2015

Synthesis and characterization of a novel chemically designed (Globo)3–DTPA–KLH antigen

Hajmohammadi M, Siadat SD, Ghorbani M, Shafiee Ardestani M, Teimourian S, Asgari V, Ahangari Cohan R, Hajmohammadi M, Hajmohammadi A, Behzadi R, Rajabnezhad S, Namvar Asl N

Drug Design, Development and Therapy 2015, 9:217-239

Published Date: 22 December 2014

Clinicopathological significance and potential drug target of T-cadherin in NSCLC

Wang Z, Wang B, Guo H, Shi G, Hong X

Drug Design, Development and Therapy 2015, 9:207-216

Published Date: 19 December 2014

A thorough QT study in the context of an uptitration regimen with selexipag, a selective oral prostacyclin receptor agonist

Hoch M, Darpo B, Remenova T, Stoltz R, Zhou M, Kaufmann P, Bruderer S, Dingemanse J

Drug Design, Development and Therapy 2015, 9:175-185

Published Date: 17 December 2014

Clinical effect of a positive surgical margin after hepatectomy on survival of patients with intrahepatic cholangiocarcinoma

Yeh CN, Hsieh FJ, Chiang KC, Chen JS, Yeh TS, Jan YY, Chen MF

Drug Design, Development and Therapy 2015, 9:163-174

Published Date: 17 December 2014

Analysis of malignancies in patients after heart transplantation with subsequent immunosuppressive therapy

Rivinius R, Helmschrott M, Ruhparwar A, Schmack B, Klein B, Erbel C, Gleissner CA, Akhavanpoor M, Frankenstein L, Darche FF, Thomas D, Ehlermann P, Bruckner T, Katus HA, Doesch AO

Drug Design, Development and Therapy 2015, 9:93-102

Published Date: 17 December 2014

An evidence-based update on the pharmacological activities and possible molecular targets of Lycium barbarum polysaccharides

Cheng J, Zhou ZW, Sheng HP, He LJ, Fan XW, He ZX, Sun T, Zhang X, Zhao RJ, Gu L, Cao CH, Zhou SF

Drug Design, Development and Therapy 2015, 9:33-78

Published Date: 17 December 2014

Microemulsion of babassu oil as a natural product to improve human immune system function

Pessoa RS, França EL, Ribeiro EB, Lanes PK, Chaud NG, Moraes LC, Honorio-França AC

Drug Design, Development and Therapy 2015, 9:21-31

Published Date: 16 December 2014

Xyloketal B, a marine compound, acts on a network of molecular proteins and regulates the activity and expression of rat cytochrome P450 3a: a bioinformatic and animal study

Su JH, Chang C, Xiang Q, Zhou ZW, Luo R, Yang L, He ZX, Yang HT, Li J, Bei Y, Xu JM, Zhang MJ, Zhang QH, Su ZJ, Huang YD, Pang JY, Zhou SF

Drug Design, Development and Therapy 2014, 8:2555-2602

Published Date: 12 December 2014

Curative treatment can be an option for patients with metastatic squamous cell cancer of the head and neck

Guenne C, Fayette J, Cosmidis A, Fuchsmann C, Tartas S, Favrel V, Céruse P

Drug Design, Development and Therapy 2014, 8:2549-2553

Published Date: 12 December 2014

Stevens–Johnson Syndrome and toxic epidermalnecrolysis: a multi-aspect comparative 7-year study from the People’s Republic of China

Sun J, Liu J, Gong QL, Ding GZ, Ma LW, Zhang LC, Lu Y

Drug Design, Development and Therapy 2014, 8:2539-2547

Published Date: 12 December 2014

Treatment of port wine stains with pulsed dye laser: a retrospective study of 848 cases in Shandong Province, People’s Republic of China

Shi W, Wang J, Lin Y, Geng J, Wang H, Gong Y, Liu H, Zhang F

Drug Design, Development and Therapy 2014, 8:2531-2538

Published Date: 12 December 2014

Sequential treatment with AT-101 enhances cisplatin chemosensitivity in human non-small cell lung cancer cells through inhibition of apurinic/apyrimidinic endonuclease 1-activated IL-6/STAT3 signaling pathway

Ren T, Shan J, Qing Y, Qian C, Li Q, Lu G, Li M, Li C, Peng Y, Luo H, Zhang S, Zhang W, Wang D, Zhou SF

Drug Design, Development and Therapy 2014, 8:2517-2529

Published Date: 12 December 2014

A new recombinant factor VIII: from genetics to clinical use

Santagostino E

Drug Design, Development and Therapy 2014, 8:2507-2515

Published Date: 12 December 2014

Dapagliflozin for the treatment of type 2 diabetes: a review of the literature

Saeed MA, Narendran P

Drug Design, Development and Therapy 2014, 8:2493-2505

Published Date: 10 December 2014

Scientometrics of anesthetic drugs and their techniques of administration, 1984–2013

Vlassakov KV, Kissin I

Drug Design, Development and Therapy 2014, 8:2463-2473

Published Date: 9 December 2014

Mesenchymal stem cell-based NK4 gene therapy in nude mice bearing gastric cancer xenografts

Zhu Y, Cheng M, Yang Z, Zeng CY, Chen J, Xie Y, Luo SW, Zhang KH, Zhou SF, Lu NH

Drug Design, Development and Therapy 2014, 8:2449-2462

Published Date: 9 December 2014

Matrix-induced autologous chondrocyte implantation for the treatment of chondral defects of the knees in Chinese patients

Zhang ZW, Zhong X, Ji HR, Tang ZB, Bai JP, Yao MM, Hou JL, Zheng MH, Wood D, Sun JZ, Zhou SF, Liu AB

Drug Design, Development and Therapy 2014, 8:2439-2448

Published Date: 5 December 2014

Clinicopathological significance and potential drug target of RUNX3 in breast cancer

Yu YY, Chen C, Kong FF, Zhang W

Drug Design, Development and Therapy 2014, 8:2423-2430

Published Date: 5 December 2014

Cisplatin-induced hyponatremia in malignancy: comparison between brand-name and generic formulation

Ochi N, Yamane H, Hotta K, Fujii H, Isozaki H, Honda Y, Yamagishi T, Kubo T, Tanimoto M, Kiura K, Takigawa N

Drug Design, Development and Therapy 2014, 8:2401-2408

Published Date: 3 December 2014

Drug development strategies for the treatment of obesity: how to ensure efficacy, safety, and sustainable weight loss

Barja-Fernandez S, Leis R, Casanueva FF, Seoane LM

Drug Design, Development and Therapy 2014, 8:2391-2400

Published Date: 1 December 2014

Discovery of potential drugs for human-infecting H7N9 virus containing R294K mutation

He JY, Li C, Wu G

Drug Design, Development and Therapy 2014, 8:2377-2390

Published Date: 1 December 2014

Scleral melt following Retisert intravitreal fluocinolone implant

Georgalas I, Koutsandrea C, Papaconstantinou D, Mpouritis D, Petrou P

Drug Design, Development and Therapy 2014, 8:2373-2375

Published Date: 28 November 2014

CCL19 and CCL21 modulate the inflammatory milieu in atherosclerotic lesions

Akhavanpoor M, Gleissner CA, Gorbatsch S, Doesch AO, Akhavanpoor H, Wangler S, Jahn F, Lasitschka F, Katus HA, Erbel C

Drug Design, Development and Therapy 2014, 8:2359-2371

Published Date: 27 November 2014

Interleukin 1 inhibition with anakinra in adult-onset Still disease: a meta-analysis of its efficacy and safety

Hong D, Yang Z, Han SY, Liang X, Ma K, Zhang X

Drug Design, Development and Therapy 2014, 8:2345-2357

Published Date: 25 November 2014

Characterization and in vitro studies of the anticancer effect of oxidized carbon nanotubes functionalized with betulinic acid

Tan JM, Karthivashan G, Arulselvan P, Fakurazi S, Hussein MZ

Drug Design, Development and Therapy 2014, 8:2333-2343

Published Date: 20 November 2014

Pilot Phase II study of mazindol in children with attention deficit/hyperactivity disorder

Konofal E, Zhao W, Laouénan C, Lecendreux M, Kaguelidou F, Benadjaoud L, Mentré F, Jacqz-Aigrain E

Drug Design, Development and Therapy 2014, 8:2321-2332

Published Date: 11 December 2014

Choosing preclinical study models of diabetic retinopathy: key problems for consideration

Mi XS, Yuan TF, Ding Y, Zhong JX, So KF

Drug Design, Development and Therapy 2014, 8:2311-2319

Published Date: 18 November 2014

Leptin signaling molecular actions and drug target in hepatocellular carcinoma

Jiang N, Sun R, Sun Q

Drug Design, Development and Therapy 2014, 8:2295-2302

Published Date: 14 November 2014

Inhibition of cardiac Kv1.5 potassium current by the anesthetic midazolam: mode of action

Vonderlin N, Fischer F, Zitron E, Seyler C, Scherer D, Thomas D, Katus HA, Scholz EP

Drug Design, Development and Therapy 2014, 8:2263-2271

Published Date: 7 November 2014

Identification of novel multitargeted PPARα/γ/δ pan agonists by core hopping of rosiglitazone

Wang XJ, Zhang J, Wang SQ, Xu WR, Cheng XC, Wang RL

Drug Design, Development and Therapy 2014, 8:2255-2262

Published Date: 7 November 2014

Women taking the “blue pill” (sildenafil citrate): such a big deal?

Lo Monte G, Graziano A, Piva I, Marci R

Drug Design, Development and Therapy 2014, 8:2251-2254

Published Date: 7 November 2014

Early non-steady-state population pharmacokinetics of oral cyclosporine in renal transplant recipients

Baek H, Han S, Yim DS, Kim SJ, Lee SY, Jang HR, Lee JE, Kim DJ, Kim YG, Oh HY, Huh W

Drug Design, Development and Therapy 2014, 8:2241-2249

Published Date: 7 November 2014