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Drug Design, Development and Therapy


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A targeted therapy for melanoma by graphene oxide composite with microRNA carrier

Liu C, Xie H, Yu JG, Chen X, Tang S, Sun L, Chen X, Peng D, Zhang X, Zhou J

Drug Design, Development and Therapy 2018, 12:3095-3106

Published Date: 21 September 2018

Comparison of the efficacy and survival analysis of neoadjuvant chemotherapy for Her-2-positive breast cancer

Li S, Wei W, Jiang Y, Li Q, Huang Q, Yang H, Liu J

Drug Design, Development and Therapy 2018, 12:3085-3093

Published Date: 21 September 2018

Effects of hydroxyethyl starch 130/0.4 on the kidney tissue of rats with ureteral obstruction

Güneş I, Süngü N, Kılıçarslan A, Şıvgın V, Alkan M, Küçük A, Boyunağa H, Ünal Y, Arslan M

Drug Design, Development and Therapy 2018, 12:3061-3070

Published Date: 20 September 2018

Chemotherapeutic drug targeting to lungs by way of microspheres after intravenous administration

Sangi S, SreeHarsha N, Bawadekji A, Al Ali M

Drug Design, Development and Therapy 2018, 12:3051-3060

Published Date: 18 September 2018

Sintered dicalcium pyrophosphate treatment attenuates estrogen deficiency-associated disc degeneration in ovariectomized rats

Chen CH, Chen WC, Lin CY, Chen CH, Tsuang YH, Kuo YJ

Drug Design, Development and Therapy 2018, 12:3033-3041

Published Date: 18 September 2018

Zoledronate inhibits fibroblasts’ proliferation and activation via targeting TGF-β signaling pathway

Zhao Z, Shen W, Zhu H, Lin L, Jiang G, Zhu Y, Song H, Wu L

Drug Design, Development and Therapy 2018, 12:3021-3031

Published Date: 17 September 2018

Novel anti-inflammatory film as a delivery system for the external medication with bioactive phytochemical “Apocynin”

Anter HM, Abu Hashim II, Awadin W, Meshali MM

Drug Design, Development and Therapy 2018, 12:2981-3001

Published Date: 13 September 2018

Astragaloside IV represses high glucose-induced mesangial cells activation by enhancing autophagy via SIRT1 deacetylation of NF-κB P65 subunit

Wang X, Gao Y, Tian N, Zhu Z, Wang T, Xu J, Wu B, Zhang N

Drug Design, Development and Therapy 2018, 12:2971-2980

Published Date: 12 September 2018

Saikosaponin A modulates remodeling of Kv4.2-mediated A-type voltage-gated potassium currents in rat chronic temporal lobe epilepsy

Hong Y, Deng N, Jin H, Xuan Z, Qian YX, Wu ZY, Xie W

Drug Design, Development and Therapy 2018, 12:2945-2958

Published Date: 11 September 2018

GlycoPEGylated recombinant factor IX for hemophilia B in context

Santagostino E, Mancuso ME

Drug Design, Development and Therapy 2018, 12:2933-2943

Published Date: 11 September 2018

Papaverine hydrochloride containing nanostructured lyotropic liquid crystal formulation as a potential drug delivery system for the treatment of erectile dysfunction

Berkó S, Zsikó S, Deák G, Gácsi A, Kovács A, Budai-Szűcs M, Pajor L, Bajory Z, Csányi E

Drug Design, Development and Therapy 2018, 12:2923-2931

Published Date: 12 September 2018

In vitro and in vivo evaluation of cephalosporins for the treatment of Lyme disease

Pothineni VR, Parekh MB, Babar MM, Ambati A, Maguire P, Inayathullah M, Kim K, Tayebi L, Potula HS, Rajadas J

Drug Design, Development and Therapy 2018, 12:2915-2921

Published Date: 11 September 2018

Chemopreventive activity of sulforaphane

Jiang X, Liu Y, Ma L, Ji R, Qu Y, Xin Y, Lv G

Drug Design, Development and Therapy 2018, 12:2905-2913

Published Date: 11 September 2018

Inhibitor of IGF1 receptor alleviates the inflammation process in the diabetic kidney mouse model without activating SOCS2

Li J, Dong R, Yu J, Yi S, Da J, Yu F, Zha Y

Drug Design, Development and Therapy 2018, 12:2887-2896

Published Date: 11 September 2018

Eremomycin pyrrolidide: a novel semisynthetic glycopeptide with improved chemotherapeutic properties

Olsufyeva EN, Shchekotikhin AE, Bychkova EN, Pereverzeva ER, Treshalin ID, Mirchink EP, Isakova EB, Chernobrovkin MG, Kozlov RS, Dekhnich AV, Preobrazhenskaya MN

Drug Design, Development and Therapy 2018, 12:2875-2885

Published Date: 10 September 2018

Profile of atezolizumab in the treatment of metastatic non-small-cell lung cancer: patient selection and perspectives

Facchinetti F, Bordi P, Leonetti A, Buti S, Tiseo M

Drug Design, Development and Therapy 2018, 12:2857-2873

Published Date: 10 September 2018

Macrocyclic lactones inhibit nasopharyngeal carcinoma cells proliferation through PAK1 inhibition and reduce in vivo tumor growth

Gallardo F, Mariamé B, Gence R, Tilkin-Mariamé AF

Drug Design, Development and Therapy 2018, 12:2805-2814

Published Date: 7 September 2018

The effect of food and liquid pH on the integrity of enteric-coated beads from cysteamine bitartrate delayed-release capsules

Pavloff N, Hauser TA, Williams C, Isbell SL, Cadieux B, Johnson M

Drug Design, Development and Therapy 2018, 12:2795-2804

Published Date: 6 September 2018

Efficacy and safety of a fixed-dose combination of nimesulide/pantoprazole compared to naproxen/esomeprazole for pain relief in patients with osteoarticular diseases and dyspeptic symptoms

Scheinberg M, Pott Júnior H, Macêdo EA, Bocchi de Oliveira MF, Ecclissato C, Amazonas RB

Drug Design, Development and Therapy 2018, 12:2775-2783

Published Date: 6 September 2018

Are laboratory parameter (biomarker) values similar to the healthy volunteer reference range in all patient populations?

Brott DA, Goodman MJ, Hermann RP, Merz M, Calvo R, Poorkhalkali N, Kiazand A

Drug Design, Development and Therapy 2018, 12:2757-2773

Published Date: 6 September 2018

Safety and efficacy of elbasvir/grazoprevir for the treatment of chronic hepatitis C: current evidence

Morikawa K, Nakamura A, Shimazaki T, Sakamoto N

Drug Design, Development and Therapy 2018, 12:2749-2756

Published Date: 5 September 2018

17β-estradiol ameliorates oxidative stress and blue light-emitting diode-induced retinal degeneration by decreasing apoptosis and enhancing autophagy

Wei Q, Liang X, Peng Y, Yu D, Zhang R, Jin H, Fan J, Cai W, Ren C, Yu J

Drug Design, Development and Therapy 2018, 12:2715-2730

Published Date: 4 September 2018

Fasudil inhibits actin polymerization and collagen synthesis and induces apoptosis in human urethral scar fibroblasts via the Rho/ROCK pathway

Li XD, Wu YP, Chen SH, Liang YC, Lin TT, Lin T, Wei Y, Xue XY, Zheng QS, Xu N

Drug Design, Development and Therapy 2018, 12:2707-2713

Published Date: 3 September 2018

The total alkaloids from Coptis chinensis Franch improve cognitive deficits in type 2 diabetic rats

Li JC, Shen XF, Shao JA, Tao MM, Gu J, Li J, Huang N

Drug Design, Development and Therapy 2018, 12:2695-2706

Published Date: 31 August 2018

Asenapine pharmacokinetics and tolerability in a pediatric population

Dogterom P, Riesenberg R, de Greef R, Dennie J, Johnson M, Pilla Reddy V, Miltenburg AMM, Findling RL, Jakate A, Carrothers TJ, Troyer MD

Drug Design, Development and Therapy 2018, 12:2677-2693

Published Date: 30 August 2018

Profile of pitolisant in the management of narcolepsy: design, development, and place in therapy

Romigi A, Vitrani G, Lo Giudice T, Centonze D, Franco V

Drug Design, Development and Therapy 2018, 12:2665-2675

Published Date: 30 August 2018

Inhibiting eEF-2 kinase-mediated autophagy enhanced the cytocidal effect of AKT inhibitor on human nasopharyngeal carcinoma

Zhao YY, Tian Y, Liu L, Zhan JH, Hou X, Chen X, Zhou T, Huang Y, Zhang L

Drug Design, Development and Therapy 2018, 12:2655-2663

Published Date: 29 August 2018

A novel multifunctional anti-CEA-IL15 molecule displays potent antitumor activities

Liu Y, Wang Y, Xing J, Li Y, Liu J, Wang Z

Drug Design, Development and Therapy 2018, 12:2645-2654

Published Date: 29 August 2018

Spectroscopic and molecular modeling studies of binding interaction between bovine serum albumin and roflumilast

Wani TA, Bakheit AH, Ansari MN, Al-Majed ARA, Al-Qahtani BM, Zargar S

Drug Design, Development and Therapy 2018, 12:2627-2634

Published Date: 28 August 2018

Fabrication and characterization of dexibuprofen nanocrystals using microchannel fluidic rector

Khan J, Bashir S, Khan MA, Mohammad MA, Isreb M

Drug Design, Development and Therapy 2018, 12:2617-2626

Published Date: 29 August 2018

Genetically engineered drug rhCNB induces apoptosis and cell cycle arrest in both gastric cancer cells and hepatoma cells

Guo Y, Huang Y, Tian S, Xie X, Xing G, Fu J

Drug Design, Development and Therapy 2018, 12:2567-2575

Published Date: 20 August 2018

MEK inhibitors for the treatment of NRAS mutant melanoma

Sarkisian S, Davar D

Drug Design, Development and Therapy 2018, 12:2553-2565

Published Date: 20 August 2018

Development of prednisolone-containing eye drop formulations by cyclodextrin complexation and antimicrobial, mucoadhesive biopolymer

Bíró T, Horvát G, Budai-Szűcs M, Csányi E, Urbán E, Facskó A, Szabó-Révész P, Csóka I, Aigner Z

Drug Design, Development and Therapy 2018, 12:2529-2537

Published Date: 15 August 2018

Current research for a vaccine against Lassa hemorrhagic fever virus

Warner BM, Safronetz D, Stein DR

Drug Design, Development and Therapy 2018, 12:2519-2527

Published Date: 14 August 2018

Baicalin provides neuroprotection in traumatic brain injury mice model through Akt/Nrf2 pathway

Fang J, Wang H, Zhou J, Dai W, Zhu Y, Zhou Y, Wang X, Zhou M

Drug Design, Development and Therapy 2018, 12:2497-2508

Published Date: 10 August 2018

Milnacipran poorly modulates pain in patients suffering from fibromyalgia: a randomized double-blind controlled study

Pickering G, Macian N, Delage N, Picard P, Cardot JM, Sickout-Arondo S, Giron F, Dualé C, Pereira B, Marcaillou F

Drug Design, Development and Therapy 2018, 12:2485-2496

Published Date: 10 August 2018

Preclinical safety evaluation of hepatic arterial infusion of oncolytic poxvirus

Cho E, Ryu EJ, Jiang F, Jeon UB, Cho M, Kim CH, Kim M, Kim ND, Hwang TH

Drug Design, Development and Therapy 2018, 12:2467-2474

Published Date: 8 August 2018

Systematic review and meta-analysis of the benefit of celecoxib in treating advanced non-small-cell lung cancer

Yi L, Zhang W, Zhang H, Shen J, Zou J, Luo P, Zhang J

Drug Design, Development and Therapy 2018, 12:2455-2466

Published Date: 7 August 2018

Antihyperlipidemic studies of newly synthesized phenolic derivatives: in silico and in vivo approaches

Aqeel MT, ur-Rahman N, Khan A, Ashraf Z, Latif M, Rafique H, Rasheed U

Drug Design, Development and Therapy 2018, 12:2443-2453

Published Date: 9 August 2018

Monitoring antiangiogenesis of bevacizumab in zebrafish

Zhang J, Gao BL, Zhang WC, Qian ZJ, Xiang Y

Drug Design, Development and Therapy 2018, 12:2423-2430

Published Date: 6 August 2018

Sinomenine inhibits the growth of melanoma by enhancement of autophagy via PI3K/AKT/mTOR inhibition

Sun Z, Zheng L, Liu X, Xing W, Liu X

Drug Design, Development and Therapy 2018, 12:2413-2421

Published Date: 6 August 2018

Zafirlukast in combination with pseudohypericin attenuates spinal cord injury and motor function in experimental mice

Chen XG, Hua F, Wang SG, Xu YY, Yue HT, Sun J

Drug Design, Development and Therapy 2018, 12:2389-2402

Published Date: 1 August 2018

Comparison of biosimilar filgrastim with a reference product: pharmacokinetics, pharmacodynamics, and safety profiles in healthy volunteers

Choi C, Yoo BW, Kim CO, Hong T, Jin BH, Seo KS, Jang JY, Park MS

Drug Design, Development and Therapy 2018, 12:2381-2387

Published Date: 1 August 2018

Pharmacological mechanism of roflumilast in the treatment of asthma–COPD overlap

Zhang X, Chen Y, Fan L, Ye J, Fan J, Xu X, You D, Liu S, Chen X, Luo P

Drug Design, Development and Therapy 2018, 12:2371-2379

Published Date: 1 August 2018

Doxorubicin-conjugated dexamethasone induced MCF-7 apoptosis without entering the nucleus and able to overcome MDR-1-induced resistance

Chaikomon K, Chattong S, Chaiya T, Tiwawech D, Sritana-Anant Y, Sereemaspun A, Manotham K

Drug Design, Development and Therapy 2018, 12:2361-2369

Published Date: 1 August 2018

Discovery of nonnucleoside inhibitors of polymerase from infectious pancreatic necrosis virus (IPNV)

Bello-Pérez M, Falco A, Galiano V, Coll J, Perez L, Encinar JA

Drug Design, Development and Therapy 2018, 12:2337-2359

Published Date: 30 July 2018

Role of janus kinase inhibitors in the treatment of alopecia areata

Triyangkulsri K, Suchonwanit P

Drug Design, Development and Therapy 2018, 12:2323-2335

Published Date: 27 July 2018

Care pathways and treatment patterns for patients with heart failure in China: results from a cross-sectional survey

Jackson JDS, Cotton SE, Bruce Wirta S, Proenca CC, Zhang M, Lahoz R, Balas B, Calado FJ

Drug Design, Development and Therapy 2018, 12:2311-2321

Published Date: 26 July 2018

Pharmacokinetic interaction between fimasartan and atorvastatin in healthy male volunteers

Choi Y, Lee S, Jang IJ, Yu KS

Drug Design, Development and Therapy 2018, 12:2301-2309

Published Date: 24 July 2018

Effects of the traditional Chinese medicine baicalein on the viability of random pattern skin flaps in rats

Lin R, Lin J, Li S, Ding J, Wu H, Xiang G, Li S, Huang Y, Lin D, Gao W, Kong J, Xu H, Zhou K

Drug Design, Development and Therapy 2018, 12:2267-2276

Published Date: 23 July 2018

The effects of bisphosphonates on osteoporotic patients after lumbar fusion: a meta-analysis

Liu WB, Zhao WT, Shen P, Zhang FJ

Drug Design, Development and Therapy 2018, 12:2233-2240

Published Date: 17 July 2018

Radiosensitivity enhancement by combined treatment of nimotuzumab and celecoxib on nasopharyngeal carcinoma cells

Huang JF, Yuan XP, Pang QF, Zhang HW, Yu JH, Yang B, Zhou LY, Zhang FZ, Liu FJ

Drug Design, Development and Therapy 2018, 12:2223-2231

Published Date: 16 July 2018

Emodin mitigates podocytes apoptosis induced by endoplasmic reticulum stress through the inhibition of the PERK pathway in diabetic nephropathy

Tian N, Gao Y, Wang X, Wu X, Zou D, Zhu Z, Han ZJ, Wang T, Shi Y

Drug Design, Development and Therapy 2018, 12:2195-2211

Published Date: 13 July 2018

Antifungal activity of Cardiospermum halicacabum L. (Sapindaceae) against Trichophyton rubrum occurs through molecular interaction with fungal Hsp90

Gaziano R, Campione E, Iacovelli F, Marino D, Pica F, Di Francesco P, Aquaro S, Menichini F, Falconi M, Bianchi L

Drug Design, Development and Therapy 2018, 12:2185-2193

Published Date: 12 July 2018

A case report of toxic epidermal necrolysis associated with AZD-9291

Wang J, Cheng XY, Lu Y, Zhou BR

Drug Design, Development and Therapy 2018, 12:2163-2167

Published Date: 11 July 2018

Effect of green tea catechins on the pharmacokinetics of digoxin in humans

Kim TE, Shin KH, Park JE, Kim MG, Yun YM, Choi DH, Kwon KJ, Lee J

Drug Design, Development and Therapy 2018, 12:2139-2147

Published Date: 10 July 2018

Development of a tin oxide carrier with mesoporous structure for improving the dissolution rate and oral relative bioavailability of fenofibrate

Bai A, Wu C, Liu X, Lv H, Xu X, Cao Y, Shang W, Hu L, Liu Y

Drug Design, Development and Therapy 2018, 12:2129-2138

Published Date: 10 July 2018

Self-nanomicellizing solid dispersion of edaravone: part II: in vivo assessment of efficacy against behavior deficits and safety in Alzheimer’s disease model

Parikh A, Kathawala K, Li JT, Chen C, Shan Z, Cao X, Wang YJ, Garg S, Zhou XF

Drug Design, Development and Therapy 2018, 12:2111-2128

Published Date: 9 July 2018

Design and development of ICCA as a dual inhibitor of GPIIb/IIIa and P-selectin receptors

Chen H, Lu A, Zhang X, Gui L, Wang YN, Wu J, Feng H, Peng S, Zhao M

Drug Design, Development and Therapy 2018, 12:2097-2110

Published Date: 9 July 2018

Safety and efficacy of durvalumab (MEDI4736) in various solid tumors

Yang H, Shen K, Zhu C, Li Q, Zhao Y, Ma X

Drug Design, Development and Therapy 2018, 12:2085-2096

Published Date: 6 July 2018

Self-nanomicellizing solid dispersion of edaravone: part I – oral bioavailability improvement

Parikh A, Kathawala K, Tan CC, Garg S, Zhou XF

Drug Design, Development and Therapy 2018, 12:2051-2069

Published Date: 5 July 2018

Antiangiogenic cytokines as potential new therapeutic targets for resveratrol in diabetic retinopathy

Popescu M, Bogdan C, Pintea A, Rugină D, Ionescu C

Drug Design, Development and Therapy 2018, 12:1985-1996

Published Date: 3 July 2018

Pharmacokinetics of placental protein 13 after intravenous and subcutaneous administration in rabbits

Drobnjak T, Meiri H, Mandalà M, Huppertz B, Gizurarson S

Drug Design, Development and Therapy 2018, 12:1977-1983

Published Date: 3 July 2018

Gemcitabine hydrochloride microspheres used for intravesical treatment of superficial bladder cancer: a comprehensive in vitro/ex vivo/in vivo evaluation

Karavana SY, Ay Şenyiğit Z, Çalışkan Ç, Sevin G, İlem Özdemir D, Erzurumlu Y, Şen S, Baloğlu E

Drug Design, Development and Therapy 2018, 12:1959-1975

Published Date: 2 July 2018

Daptomycin: a comparison of two intravenous formulations

Frankenfeld C, Mittal S, Melendez Y, Mendez-Vigo L, Lamp KC, Keller KN, Bertolami SR

Drug Design, Development and Therapy 2018, 12:1953-1958

Published Date: 29 June 2018

Mechanism of Yanghe Pingchuan granules treatment for airway remodeling in asthma

Pan LY, Han YQ, Wang YZ, Chen QQ, Wu Y, Sun Y

Drug Design, Development and Therapy 2018, 12:1941-1951

Published Date: 27 June 2018

Electroporation-enhanced transdermal diclofenac sodium delivery into the knee joint in a rat model of acute arthritis

Hartmann P, Butt E, Fehér Á, Szilágyi ÁL, Jász KD, Balázs B, Bakonyi M, Berkó S, Erős G, Boros M, Horváth G, Varga E, Csányi E

Drug Design, Development and Therapy 2018, 12:1917-1930

Published Date: 27 June 2018

The mechanism of botulinum A on Raynaud syndrome

Zhou Y, Liu Y, Hao Y, Feng Y, Pan L, Liu W, Li B, Xiao L, Jin L, Nie Z

Drug Design, Development and Therapy 2018, 12:1905-1915

Published Date: 26 June 2018

Modes of cell death induced by tetrahydroisoquinoline-based analogs in MDA-MB-231 breast and A549 lung cancer cell lines

Nel M, Joubert AM, Dohle W, Potter BVL, Theron AE

Drug Design, Development and Therapy 2018, 12:1881-1904

Published Date: 25 June 2018

Additive effect of oral LDD175 to tamsulosin and finasteride in a benign prostate hyperplasia rat model

Choi BR, Kim HK, Soni KK, Karna KK, Lee SW, So I, Park JK

Drug Design, Development and Therapy 2018, 12:1855-1863

Published Date: 22 June 2018

Salidroside ameliorates autophagy and activation of hepatic stellate cells in mice via NF-κB and TGF-β1/Smad3 pathways

Feng J, Chen K, Xia Y, Wu L, Li J, Li S, Wang W, Lu X, Liu T, Guo C

Drug Design, Development and Therapy 2018, 12:1837-1853

Published Date: 22 June 2018

Sevoflurane anaesthesia during pregnancy in mice induces hearing impairment in the offspring

Shen X, Xiao Y, Li W, Chen K, Yu H

Drug Design, Development and Therapy 2018, 12:1827-1836

Published Date: 22 June 2018

Use of levosimendan in the treatment of cerebral vascular vasospasm: a case study

Onichimowski D, Nosek K, Goraj R, Jalali R, Wińska A, Pawlos A, Tuyakov B

Drug Design, Development and Therapy 2018, 12:1777-1783

Published Date: 20 June 2018

Clinical efficacy of nab-paclitaxel in patients with metastatic pancreatic cancer

De Luca R, Blasi L, Alù M, Gristina V, Cicero G

Drug Design, Development and Therapy 2018, 12:1769-1775

Published Date: 19 June 2018

Linezolid: a review of its properties, function, and use in critical care

Hashemian SMR, Farhadi T, Ganjparvar M

Drug Design, Development and Therapy 2018, 12:1759-1767

Published Date: 18 June 2018

Lights and shadows of NSAIDs in bone healing: the role of prostaglandins in bone metabolism

Lisowska B, Kosson D, Domaracka K

Drug Design, Development and Therapy 2018, 12:1753-1758

Published Date: 18 June 2018

Annatto-derived tocotrienol stimulates osteogenic activity in preosteoblastic MC3T3-E1 cells: a temporal sequential study

Wan Hasan WN, Abd Ghafar N, Chin KY, Ima-Nirwana S

Drug Design, Development and Therapy 2018, 12:1715-1726

Published Date: 13 June 2018

Effect of food on the pharmacokinetic characteristics of a single oral dose of LCB01-0371, a novel oxazolidinone antibiotic

Sunwoo J, Kim YK, Choi Y, Yu KS, Nam H, Cho YL, Yoon S, Chung JY

Drug Design, Development and Therapy 2018, 12:1707-1714

Published Date: 11 June 2018

Chloroquine and hydroxychloroquine are associated with reduced cardiovascular risk: a systematic review and meta-analysis

Liu D, Li X, Zhang Y, Kwong JSW, Li L, Zhang Y, Xu C, Li Q, Sun X, Tian H, Li S

Drug Design, Development and Therapy 2018, 12:1685-1695

Published Date: 11 June 2018

Burden of heart failure on caregivers in China: results from a cross-sectional survey

Jackson JDS, Cotton SE, Bruce Wirta S, Proenca CC, Zhang M, Lahoz R, Calado FJ

Drug Design, Development and Therapy 2018, 12:1669-1678

Published Date: 8 June 2018

Burden of heart failure on patients from China: results from a cross-sectional survey

Jackson JDS, Cotton SE, Bruce Wirta S, Proenca CC, Zhang M, Lahoz R, Calado FJ

Drug Design, Development and Therapy 2018, 12:1659-1668

Published Date: 8 June 2018

AMPK/AS160 mediates tiliroside derivatives-stimulated GLUT4 translocation in muscle cells

Zhang C, Jiang Y, Liu J, Jin M, Qin N, Chen Y, Niu W, Duan H

Drug Design, Development and Therapy 2018, 12:1581-1587

Published Date: 1 June 2018

Optimization of a combined wet milling process in order to produce poly(vinyl alcohol) stabilized nanosuspension

Bartos C, Jójárt-Laczkovich O, Katona G, Budai-Szűcs M, Ambrus R, Bocsik A, Gróf I, Deli MA, Szabó-Révész P

Drug Design, Development and Therapy 2018, 12:1567-1580

Published Date: 31 May 2018

2-Amino-1,3,4-thiadiazole as a potential scaffold for promising antimicrobial agents

Serban G, Stanasel O, Serban E, Bota S

Drug Design, Development and Therapy 2018, 12:1545-1566

Published Date: 31 May 2018

Formulation and in vitro characterization of rifampicin-loaded porous poly (ε-caprolactone) microspheres for sustained skeletal delivery

Mei Q, Luo P, Zuo Y, Li J, Zou Q, Li Y, Jiang D, Wang Y

Drug Design, Development and Therapy 2018, 12:1533-1544

Published Date: 31 May 2018

Incidence and risk of cardiac toxicities in patients with relapsed and refractory multiple myeloma treated with carfilzomib

Zhao F, Yang B, Wang J, Zhang R, Liu J, Yin F, Xu W, He C

Drug Design, Development and Therapy 2018, 12:1525-1531

Published Date: 30 May 2018

Spotlight on olaparib in the treatment of BRCA-mutated ovarian cancer: design, development and place in therapy

Lorusso D, Tripodi E, Maltese G, Lepori S, Sabatucci I, Bogani G, Raspagliesi F

Drug Design, Development and Therapy 2018, 12:1501-1509

Published Date: 29 May 2018

Pharmacological activities, mechanisms of action, and safety of salidroside in the central nervous system

Zhong ZF, Han J, Zhang JZ, Xiao Q, Hu J, Chen LD

Drug Design, Development and Therapy 2018, 12:1479-1489

Published Date: 24 May 2018

Synthesis and evaluation of ortho-[18F]fluorocelecoxib for COX-2 cholangiocarcinoma imaging

Chang CW, Yeh CN, Chung YH, Chen YR, Tien SW, Chen TW, Farn SS, Huang YC, Yu CS

Drug Design, Development and Therapy 2018, 12:1467-1478

Published Date: 24 May 2018

nab-Paclitaxel/carboplatin in elderly patients with advanced squamous non-small cell lung cancer: a retrospective analysis of a Phase III trial

Gridelli C, Chen T, Ko A, O'Brien ME, Ong TJ, Socinski MA, Postmus PE

Drug Design, Development and Therapy 2018, 12:1445-1451

Published Date: 24 May 2018

In silico and in vivo characterization of cabralealactone, solasodin and salvadorin in a rat model: potential anti-inflammatory agents

Malik A, Arooj M, Butt TT, Zahid S, Zahid F, Jafar TH, Waquar S, Gan SH, Ahmad S, Mirza MU

Drug Design, Development and Therapy 2018, 12:1431-1443

Published Date: 24 May 2018

The anti-cataract molecular mechanism study in selenium cataract rats for baicalin ophthalmic nanoparticles

Li N, Han Z, Li L, Zhang B, Liu Z, Li J

Drug Design, Development and Therapy 2018, 12:1399-1411

Published Date: 23 May 2018

Effects of hemocoagulase agkistrodon on the coagulation factors and its procoagulant activities

Li H, Huang Y, Wu X, Wu T, Cao Y, Wang Q, Qiu Y, Fu W, Zhang Q, Pang J

Drug Design, Development and Therapy 2018, 12:1385-1398

Published Date: 23 May 2018

Antihyperglycemic and anti-inflammatory effects of fermented food paste in high-fat diet and streptozotocin-challenged mice

Zulkawi N, Ng KH, Zamberi NR, Yeap SK, Satharasinghe DA, Tan SW, Ho WY, Abd Rashid NY, Md Lazim MI, Jamaluddin A, Alitheen NB, Long K

Drug Design, Development and Therapy 2018, 12:1373-1383

Published Date: 23 May 2018

REST, not REST4, is a risk factor associated with radiotherapy plus chemotherapy efficacy in glioma

Li C, Zou H, Wang ZF, Tang X, Fan X, Zhang K, Liu J, Li Z

Drug Design, Development and Therapy 2018, 12:1363-1371

Published Date: 22 May 2018

Immature platelets and antiplatelet therapy response to aspirin in Kawasaki disease

Pi L, Che D, Long HF, Fang ZZ, Li JW, Lin SY, Liu YF, Li M, Bao LJ, Li W, Zhang Y, Deng QL, Liu TC, Zhang L, Gu XQ

Drug Design, Development and Therapy 2018, 12:1353-1362

Published Date: 23 May 2018

Assessment of the effects of levosimendan and thymoquinone on lung injury after myocardial ischemia reperfusion in rats

Sezen SC, Kucuk A, Özer A, Kılıç Y, Mardin B, Alkan M, Erkent FD, Arslan M, Ünal Y, Oktar GL, Tosun M

Drug Design, Development and Therapy 2018, 12:1347-1352

Published Date: 22 May 2018

Design and preparation of derivatives of oleanolic and glycyrrhetinic acids with cytotoxic properties

Wang R, Li Y, Huai XD, Zheng QX, Wang W, Li HJ, Huai QY

Drug Design, Development and Therapy 2018, 12:1321-1336

Published Date: 21 May 2018

Glycyrrhizic acid ameliorates myocardial ischemic injury by the regulation of inflammation and oxidative state

Xu CL, Liang CH, Sun WX, Chen JD, Chen XH

Drug Design, Development and Therapy 2018, 12:1311-1319

Published Date: 18 May 2018

Vicenin-2 inhibits Wnt/β-catenin signaling and induces apoptosis in HT-29 human colon cancer cell line

Yang D, Zhang X, Zhang W, Rengarajan T

Drug Design, Development and Therapy 2018, 12:1303-1310

Published Date: 18 May 2018

Rapeseed protein-derived antioxidant peptide RAP alleviates renal fibrosis through MAPK/NF-κB signaling pathways in diabetic nephropathy

Zhang M, Yan Z, Bu L, An C, Wang D, Liu X, Zhang J, Yang W, Deng BC, Xie J, Zhang B

Drug Design, Development and Therapy 2018, 12:1255-1268

Published Date: 15 May 2018

Computer-aided design of amino acid-based therapeutics: a review

Farhadi T, Hashemian SM

Drug Design, Development and Therapy 2018, 12:1239-1254

Published Date: 14 May 2018

Semen Brassicae ameliorates hepatic fibrosis by regulating transforming growth factor-β1/Smad, nuclear factor-κB, and AKT signaling pathways in rats

Cao S, Zheng B, Chen T, Chang X, Yin B, Huang ZH, Shuai P, Han L

Drug Design, Development and Therapy 2018, 12:1205-1213

Published Date: 11 May 2018

Schisandrin B ameliorated chondrocytes inflammation and osteoarthritis via suppression of NF-κB and MAPK signal pathways

Ran J, Ma C, Xu K, Xu L, He Y, Moqbel SAA, Hu P, Jiang L, Chen W, Bao J, Xiong Y, Wu L

Drug Design, Development and Therapy 2018, 12:1195-1204

Published Date: 9 May 2018

Insight into resistance mechanism of anaplastic lymphoma kinase to alectinib and JH-VIII-157-02 caused by G1202R solvent front mutation

Wang H, Wang Y, Guo W, Du B, Huang X, Wu R, Yang B, Lin X, Wu Y

Drug Design, Development and Therapy 2018, 12:1183-1193

Published Date: 9 May 2018

The cytochrome P450 isoenzyme and some new opportunities for the prediction of negative drug interaction in vivo

Sychev DA, Ashraf GM, Svistunov AA, Maksimov ML, Tarasov VV, Chubarev VN, Otdelenov VA, Denisenko NP, Barreto GE, Aliev G

Drug Design, Development and Therapy 2018, 12:1147-1156

Published Date: 8 May 2018

Identification of Mycobacterium tuberculosis BioA inhibitors by using structure-based virtual screening

Singh S, Khare G, Bahal RK, Ghosh PC, Tyagi AK

Drug Design, Development and Therapy 2018, 12:1065-1079

Published Date: 1 May 2018

Inactivation of nuclear factor κB by MIP-based drug combinations augments cell death of breast cancer cells

Subramaniam M, Liew SK, In LLA, Awang K, Ahmed N, Nagoor NH

Drug Design, Development and Therapy 2018, 12:1053-1063

Published Date: 1 May 2018

Pharmacokinetic characteristics of telaprevir in healthy Korean male subjects and comparisons with Japanese

Choi Y, Yoon S, Matsumoto K, Ohta Y, Lee S, Yu KS, Jang IJ

Drug Design, Development and Therapy 2018, 12:1045-1051

Published Date: 30 April 2018

Spotlight on isavuconazole in the treatment of invasive aspergillosis and mucormycosis: design, development, and place in therapy

Jenks JD, Salzer HJ, Prattes J, Krause R, Buchheidt D, Hoenigl M

Drug Design, Development and Therapy 2018, 12:1033-1044

Published Date: 30 April 2018

Symmetric dimeric adamantanes for exploring the structure of two viroporins: influenza virus M2 and hepatitis C virus p7

Mandour YM, Breitinger U, Ma C, Wang J, Boeckler FM, Breitinger HG, Zlotos DP

Drug Design, Development and Therapy 2018, 12:1019-1031

Published Date: 30 April 2018

Astragalus polysaccharides protect cardiac stem and progenitor cells by the inhibition of oxidative stress-mediated apoptosis in diabetic hearts

Chen W, Ju J, Yang Y, Wang H, Chen W, Zhao X, Ye H, Zhang Y

Drug Design, Development and Therapy 2018, 12:943-954

Published Date: 20 April 2018

Comparison of tadalafil pharmacokinetics after administration of a new orodispersible film versus a film-coated tablet

Park SI, Heo SH, Kim G, Chang S, Song KH, Kim MG, Jin EH, Kim J, Lee S, Hong JH

Drug Design, Development and Therapy 2018, 12:935-942

Published Date: 20 April 2018

Chitosan–alginate BSA-gel-capsules for local chemotherapy against drug-resistant breast cancer

Shen H, Li F, Wang D, Yang Z, Yao C, Ye Y, Wang X

Drug Design, Development and Therapy 2018, 12:921-934

Published Date: 19 April 2018

Design, synthesis, and structure–activity relationships of 2-benzylidene-1-indanone derivatives as anti-inflammatory agents for treatment of acute lung injury

Xiao S, Zhang W, Chen H, Fang B, Qiu Y, Chen X, Chen L, Shu S, Zhang Y, Zhao Y, Liu Z, Liang G

Drug Design, Development and Therapy 2018, 12:887-899

Published Date: 19 April 2018

Population pharmacokinetics and dosing optimization of cefathiamidine in children with hematologic infection

Zhi LJ, Wang L, Chen XK, Zhai XY, Wen L, Dong L, Jacqz-Aigrain E, Shi ZR, Zhao W

Drug Design, Development and Therapy 2018, 12:855-862

Published Date: 17 April 2018

Reevaluation of the post-marketing safety of Shuxuening injection based on real-world and evidence-based evaluations

Wang C, Shi QP, Ding F, Jiang XD, Tang W, Yu ML, Zhu JH

Drug Design, Development and Therapy 2018, 12:757-767

Published Date: 5 April 2018

Chrysin suppresses proliferation, migration, and invasion in glioblastoma cell lines via mediating the ERK/Nrf2 signaling pathway

Wang J, Wang HD, Sun KJ, Wang XL, Pan H, Zhu JH, Ji XJ, Li X

Drug Design, Development and Therapy 2018, 12:721-733

Published Date: 3 April 2018

Preparation and in vitro/in vivo evaluation of PLGA microspheres containing norquetiapine for long-acting injection

Park CW, Lee HJ, Oh DW, Kang JH, Han CS, Kim DW

Drug Design, Development and Therapy 2018, 12:711-719

Published Date: 5 April 2018

Organic mononitrites of 1,2-propanediol act as an effective NO-releasing vasodilator in pulmonary hypertension and exhibit no cross-tolerance with nitroglycerin in anesthetized pigs

Nilsson KF, Goździk W, Frostell C, Zieliński S, Zielińska M, Ratajczak K, Skrzypczak P, Rodziewicz S, Albert J, Gustafsson LE

Drug Design, Development and Therapy 2018, 12:685-694

Published Date: 29 March 2018

The role of propranolol as a radiosensitizer in gastric cancer treatment

Liao XH, Chaudhary P, Qiu G, Che XM, Fan L

Drug Design, Development and Therapy 2018, 12:639-645

Published Date: 28 March 2018

Benralizumab in the treatment of severe asthma: design, development and potential place in therapy

Pelaia C, Vatrella A, Bruni A, Terracciano R, Pelaia G

Drug Design, Development and Therapy 2018, 12:619-628

Published Date: 21 March 2018

Rucaparib: a novel PARP inhibitor for BRCA advanced ovarian cancer

Colombo I, Lheureux S, Oza AM

Drug Design, Development and Therapy 2018, 12:605-617

Published Date: 21 March 2018

Tendinopathy: injury, repair, and current exploration

Lipman K, Wang CC, Ting K, Soo C, Zheng Z

Drug Design, Development and Therapy 2018, 12:591-603

Published Date: 20 March 2018

The hydroxypropyl–β-cyclodextrin complexation of toltrazuril for enhancing bioavailability

Zhang L, Liu MX, Lu CC, Ren DD, Fan GQ, Liu C, Liu MJ, Shu G, Peng GN, Yuan ZX, Zhong ZJ, Zhang W, Fu HL

Drug Design, Development and Therapy 2018, 12:583-589

Published Date: 19 March 2018

Bioequivalence of a biosimilar enoxaparin sodium to Clexane® after single 100 mg subcutaneous dose: results of a randomized, double-blind, crossover study in healthy volunteers

Martínez González J, Monreal M, Ayani Almagia I, Llaudó Garín J, Ochoa Díaz de Monasterioguren L, Gutierro Adúriz I

Drug Design, Development and Therapy 2018, 12:575-582

Published Date: 19 March 2018

Pharmacokinetic and bioequivalence study of a telmisartan/S-amlodipine fixed-dose combination (CKD-828) formulation and coadministered telmisartan and S-amlodipine in healthy subjects

Kang WY, Seong SJ, Ohk B, Gwon M, Kim BK, La S, Kim HJ, Cho S, Yoon Y, Yang DH, Lee HW

Drug Design, Development and Therapy 2018, 12:545-553

Published Date: 14 March 2018

Involvement of NF-κB and HSP70 signaling pathways in the apoptosis of MDA-MB-231 cells induced by a prenylated xanthone compound, α-mangostin, from Cratoxylum arborescens [Corrigendum] [Retraction]

Ibrahim MY, Mohd Hashim N, Mohan S, Mohd Ali H, Abdelwahab S, Kamalidehghan B, Ghaderian M, Dehghan F, Salim LZ, Karimian H, Yahayu M, Ee Cheng Lian G, Abdulla M, Farjam AS

Drug Design, Development and Therapy 2018, 12:533-534

Published Date: 13 March 2018

Can dexmedetomidine reduce atrial fibrillation after cardiac surgery? A systematic review and meta-analysis

Zhu ZP, Zhou HM, Ni YJ, Wu C, Zhang CJ, Ling XY

Drug Design, Development and Therapy 2018, 12:521-531

Published Date: 12 March 2018

Inhibitory effect of celecoxib on agomelatine metabolism in vitro and in vivo

He JY, Fang P, Zheng X, Wang CC, Liu TH, Zhang BW, Wen J, Xu RA

Drug Design, Development and Therapy 2018, 12:513-519

Published Date: 9 March 2018

Development of small bisquaternary cholinesterase inhibitors as drugs for pre-treatment of nerve agent poisonings

Kuca K, Karasova JZ, Soukup O, Kassa J, Novotna E, Sepsova V, Horova A, Pejchal J, Hrabinova M, Vodakova E, Jun D, Nepovimova E, Valis M, Musilek K

Drug Design, Development and Therapy 2018, 12:505-512

Published Date: 9 March 2018

Synovial tissue quantitative proteomics analysis reveals paeoniflorin decreases LIFR and ASPN proteins in experimental rheumatoid arthritis

Yang S, Xing ZH, Liu T, Zhou J, Liang QH, Tang T, Cui HJ, Peng WJ, Xiong XG, Wang Y

Drug Design, Development and Therapy 2018, 12:463-473

Published Date: 6 March 2018

Intra-articular platelet-rich plasma versus hyaluronic acid in the treatment of knee osteoarthritis: a meta-analysis

Zhang HF, Wang CG, Li H, Huang YT, Li ZJ

Drug Design, Development and Therapy 2018, 12:445-453

Published Date: 5 March 2018

Efficacy of atorvastatin on the prevention of contrast-induced acute kidney injury: a meta-analysis

Liu L, Liu Y, Wu M, Sun Y, Ma F

Drug Design, Development and Therapy 2018, 12:437-444

Published Date: 2 March 2018

Risk factors for calcineurin inhibitor nephrotoxicity after renal transplantation: a systematic review and meta-analysis

Xia T, Zhu S, Wen Y, Gao S, Li M, Tao X, Zhang F, Chen W

Drug Design, Development and Therapy 2018, 12:417-428

Published Date: 28 February 2018

Magnesium: does it reduce ischemia/reperfusion injury in an adnexal torsion rat model?

Celik Kavak E, Gulcu Bulmus F, Bulmus O, Kavak SB, Kocaman N

Drug Design, Development and Therapy 2018, 12:409-415

Published Date: 28 February 2018

Fasudil inhibits proliferation and migration of Hep-2 laryngeal carcinoma cells

Zhang X, Wu N

Drug Design, Development and Therapy 2018, 12:373-381

Published Date: 23 February 2018

Therapeutic potential of bimatoprost for the treatment of eyebrow hypotrichosis

Chanasumon N, Sriphojanart T, Suchonwanit P

Drug Design, Development and Therapy 2018, 12:365-372

Published Date: 22 February 2018

Formulation design and development of matrix diffusion controlled transdermal drug delivery of glimepiride

Akram MR, Ahmad M, Abrar A, Sarfraz RM, Mahmood A

Drug Design, Development and Therapy 2018, 12:349-364

Published Date: 21 February 2018

Short-term efficacy of intravitreal conbercept in treatment-naive patients with polypoidal choroidal vasculopathy

Peng Y, Zhang X, Li M, Liu B, Mi L, Zuo C, Wen F

Drug Design, Development and Therapy 2018, 12:339-345

Published Date: 19 February 2018

Pharmacokinetics and tolerability of eletriptan hydrobromide in healthy Korean subjects

Kim YK, Shin KH, Alderman J, Yu KS, Jang IJ, Lee S

Drug Design, Development and Therapy 2018, 12:331-337

Published Date: 19 February 2018

Berberine nanoparticles with enhanced in vitro bioavailability: characterization and antimicrobial activity

Sahibzada MUK, Sadiq A, Faidah HS, Khurram M, Amin MU, Haseeb A, Kakar M

Drug Design, Development and Therapy 2018, 12:303-312

Published Date: 14 February 2018

Comparison of the long-term efficacy and safety of generic tacrolimus, Tacrobell, with Prograf in liver transplant recipients

Choi HJ, Kim DG, Kwak BJ, Han JH, Hong TH, You YK

Drug Design, Development and Therapy 2018, 12:295-301

Published Date: 13 February 2018

Asthma and poly(ADP-ribose) polymerase inhibition: a new therapeutic approach

Zaffini R, Gotte G, Menegazzi M

Drug Design, Development and Therapy 2018, 12:281-293

Published Date: 12 February 2018

Reference ranges for antiepileptic drugs revisited: a practical approach to establish national guidelines

Reimers A, Berg JA, Burns ML, Brodtkorb E, Johannessen SI, Johannessen Landmark C

Drug Design, Development and Therapy 2018, 12:271-280

Published Date: 8 February 2018

Experimental and molecular modeling approach to optimize suitable polymers for fabrication of stable fluticasone nanoparticles with enhanced dissolution and antimicrobial activity

Ahmed S, Govender T, Khan I, ur Rehman N, Ali W, Shah SMH, Khan S, Hussain Z, Ullah R, Alsaid MS

Drug Design, Development and Therapy 2018, 12:255-269

Published Date: 5 February 2018

Dysregulation of Neuregulin-1/ErbB signaling in the hippocampus of rats after administration of doxorubicin

Liao D, Guo Y, Xiang D, Dang R, Xu P, Cai H, Cao L, Jiang P

Drug Design, Development and Therapy 2018, 12:231-239

Published Date: 30 January 2018

Durvalumab: an investigational anti-PD-L1 monoclonal antibody for the treatment of urothelial carcinoma

Faiena I, Cummings AL, Crosetti AM, Pantuck AJ, Chamie K, Drakaki A

Drug Design, Development and Therapy 2018, 12:209-215

Published Date: 23 January 2018

Bispecific antibodies: design, therapy, perspectives

Sedykh SE, Prinz VV, Buneva VN, Nevinsky GA

Drug Design, Development and Therapy 2018, 12:195-208

Published Date: 22 January 2018

Anticonvulsant and reproductive toxicological studies of the imidazole-based histamine H3R antagonist 2-18 in mice

Bastaki SM, Abdulrazzaq YM, Shafiullah M, Więcek M, Kieć-Kononowicz K, Sadek B

Drug Design, Development and Therapy 2018, 12:179-194

Published Date: 19 January 2018

Involvement of microRNA-146a in diabetic peripheral neuropathy through the regulation of inflammation

Feng Y, Chen L, Luo Q, Wu M, Chen Y, Shi X

Drug Design, Development and Therapy 2018, 12:171-177

Published Date: 17 January 2018

Efficacy and side effects of intravenous theophylline in acute asthma: a systematic review and meta-analysis

Mahemuti G, Zhang H, Li J, Tieliwaerdi N, Ren L

Drug Design, Development and Therapy 2018, 12:99-120

Published Date: 10 January 2018

Peptides derived from Plasmodium falciparum leucine-rich repeat 1 bind to serine/threonine phosphatase type 1 and inhibit parasite growth in vitro

Pierrot C, Zhang X, Zanghi G, Fréville A, Rebollo A, Khalife J

Drug Design, Development and Therapy 2018, 12:85-88

Published Date: 9 January 2018

Quantitative assessment of the effects of chitosan intervention on blood pressure control

Huang H, Zou Y, Chi H

Drug Design, Development and Therapy 2018, 12:67-75

Published Date: 28 December 2017

The oral bioavailability, excretion and cytochrome P450 inhibition properties of epiberberine: an in vivo and in vitro evaluation

Chen N, Yang X, Guo C, Bi X, Chen J, Chen H, Li H, Lin H, Zhang Y

Drug Design, Development and Therapy 2018, 12:57-65

Published Date: 28 December 2017

Portulaca oleracea L. alleviates liver injury in streptozotocin-induced diabetic mice

Zheng G, Mo F, Ling C, Peng H, Gu W, Li M, Chen Z

Drug Design, Development and Therapy 2018, 12:47-55

Published Date: 28 December 2017

Clinical features of hypophosphatemic osteomalacia induced by long-term low-dose adefovir dipivoxil

Zhu S, Yang YH, Gao RW, Li R, Zou YZ, Feng L, Zhang B

Drug Design, Development and Therapy 2018, 12:41-45

Published Date: 27 December 2017

Leishmaniasis in humans: drug or vaccine therapy?

Ghorbani M, Farhoudi R

Drug Design, Development and Therapy 2018, 12:25-40

Published Date: 22 December 2017

Intra-articular collagenase injection increases range of motion in a rat knee flexion contracture model

Wong K, Trudel G, Laneuville O

Drug Design, Development and Therapy 2018, 12:15-24

Published Date: 21 December 2017

HX575: established biosimilarity in the treatment of renal anemia and 10 years of clinical experience

Dellanna F, Goldsmith D, Krendyukov A, Seidl A, Höbel N, Combe C

Drug Design, Development and Therapy 2018, 12:9-14

Published Date: 18 December 2017

Resveratrol as a potential therapeutic drug for respiratory system diseases

Zhu X, Lei X, Dong W

Drug Design, Development and Therapy 2017, 11:3591-3598

Published Date: 15 December 2017

EUREKA study – the evaluation of real-life use of a biophotonic system in chronic wound management: an interim analysis

Romanelli M, Piaggesi A, Scapagnini G, Dini V, Janowska A, Iacopi E, Scarpa C, Fauverghe S, Bassetto F

Drug Design, Development and Therapy 2017, 11:3551-3558

Published Date: 11 December 2017

Comparative pharmacokinetics of a fixed-dose combination vs concomitant administration of telmisartan and S-amlodipine in healthy adult volunteers

Oh M, Park SE, Ghim JL, Choi YK, Shim EJ, Shin JG, Kim EY

Drug Design, Development and Therapy 2017, 11:3543-3550

Published Date: 11 December 2017

Gut microbiota–derived short-chain fatty acids and kidney diseases

Li L, Ma L, Fu P

Drug Design, Development and Therapy 2017, 11:3531-3542

Published Date: 11 December 2017

Regulation profile of the intestinal peptide transporter 1 (PepT1)

Wang CY, Liu S, Xie XN, Tan ZR

Drug Design, Development and Therapy 2017, 11:3511-3517

Published Date: 8 December 2017

Functional assessment of CYP3A4 allelic variants on lidocaine metabolism in vitro

Fang P, Tang P, Xu R, Zheng X, Wen J, Bao S, Cai J, Hu G

Drug Design, Development and Therapy 2017, 11:3503-3510

Published Date: 7 December 2017

Anacetrapib as a potential cardioprotective strategy

Di Bartolo BA, Nicholls SJ

Drug Design, Development and Therapy 2017, 11:3497-3502

Published Date: 7 December 2017

Involvement of poly(ADP-ribose) polymerase-1 in development of spinal cord injury in Chinese individuals: a Chinese clinical study

Meng Q, Yang G, Li R, Nie J, Zhou W, Yu H, Chen B, Jiang L, Shang J

Drug Design, Development and Therapy 2017, 11:3491-3495

Published Date: 6 December 2017

Preparation and evaluation of RGD and TAT co-modified docetaxel-loaded liposome

Zhu R, Tian Y

Drug Design, Development and Therapy 2017, 11:3481-3489

Published Date: 6 December 2017

Variability in the therapeutic management of advanced ovarian cancer patients: a five-country survey of oncologists

Audibert C, Perlaky A, Stuntz M, Glass D

Drug Design, Development and Therapy 2017, 11:3471-3479

Published Date: 6 December 2017

Hepatoprotective effect of calculus bovis sativus on nonalcoholic fatty liver disease in mice by inhibiting oxidative stress and apoptosis of hepatocytes

He WX, Xu YJ, Zhang CL, Lu JL, Li J, Xiang D, Yang JY, Chang MJ, Liu D

Drug Design, Development and Therapy 2017, 11:3449-3460

Published Date: 5 December 2017

High-dose atorvastatin versus moderate dose on early vascular protection after ST-elevation myocardial infarction

Gavazzoni M, Gorga E, Derosa G, Maffioli P, Metra M, Raddino R

Drug Design, Development and Therapy 2017, 11:3425-3434

Published Date: 4 December 2017

A novel transdermal nanoethosomal gel of betahistine dihydrochloride for weight gain control: in-vitro and in-vivo characterization

El-Menshawe SF, Ali AA, Halawa AA, Srag El-Din AS

Drug Design, Development and Therapy 2017, 11:3377-3388

Published Date: 28 November 2017

The coexpression of multi-immune inhibitory receptors on T lymphocytes in primary non-small-cell lung cancer

Guo WJ, Liu SH, Zhang XL, Chen YT, Qian RL, Zou ZY, Chen X, Luo P

Drug Design, Development and Therapy 2017, 11:3367-3376

Published Date: 28 November 2017

Andrographolide enhanced 5-fluorouracil-induced antitumor effect in colorectal cancer via inhibition of c-MET pathway

Su M, Qin B, Liu F, Chen Y, Zhang R

Drug Design, Development and Therapy 2017, 11:3333-3341

Published Date: 23 November 2017

Fentanyl-induced respiratory depression is attenuated in pregnant patients

Cao X, Liu S, Sun J, Yu M, Fang Y, Ding Z

Drug Design, Development and Therapy 2017, 11:3325-3332

Published Date: 22 November 2017

Severe hypertriglyceridemia and colchicine intoxication following suicide attempt

Lev S, Snyder D, Azran C, Zolotarsky V, Dahan A

Drug Design, Development and Therapy 2017, 11:3321-3324

Published Date: 22 November 2017

Anticancer effect of dentatin and dentatin-hydroxypropyl-β-cyclodextrin complex on human colon cancer (HT-29) cell line

AL-Abboodi AS, Rasedee A, Abdul AB, Taufiq-Yap YH, Alkaby WA, Ghaji MS, Waziri PM, Al-Qubaisi MS

Drug Design, Development and Therapy 2017, 11:3309-3319

Published Date: 23 November 2017

Pharmacodynamic testing and new validated HPLC method to assess the interchangeability between multi-source orlistat capsules

Zaid AN, Zohud N, E'layan B, Aburadi T, Jaradat N, Ali I, Hussein F, Ghanem M, Qaddomi A, Abu Zaaror Y

Drug Design, Development and Therapy 2017, 11:3291-3298

Published Date: 21 November 2017

In silico-based identification of human α-enolase inhibitors to block cancer cell growth metabolically

Lung J, Chen KL, Hung CH, Chen CC, Hung MS, Lin YC, Wu CY, Lee KD, Shih NY, Tsai YH

Drug Design, Development and Therapy 2017, 11:3281-3290

Published Date: 16 November 2017

Differences of statin activity in 2D and 3D pancreatic cancer cell cultures

Paškevičiūtė M, Petrikaitė V

Drug Design, Development and Therapy 2017, 11:3273-3280

Published Date: 16 November 2017

Role of nebulized glycopyrrolate in the treatment of chronic obstructive pulmonary disease

Santus P, Radovanovic D, Cristiano A, Valenti V, Rizzi M

Drug Design, Development and Therapy 2017, 11:3257-3271

Published Date: 15 November 2017

Novel production method of innovative antiangiogenic and antitumor small peptides in Escherichia coli

Setrerrahmane S, Yu J, Hao J, Zheng H, Xu H

Drug Design, Development and Therapy 2017, 11:3207-3220

Published Date: 8 November 2017

Impact of baseline blood pressure on the magnitude of blood pressure lowering by nifedipine gastrointestinal therapeutic system: refreshing the Wilder’s principle

Hu HJ, Zhang JD, Wang Y, Tian ZJ, Liu DM, Zhang GM, Gu GQ, Zheng HM, Xie RQ, Cui W

Drug Design, Development and Therapy 2017, 11:3179-3186

Published Date: 6 November 2017

Baracle® vs Baraclude® for 48 weeks in patients with treatment-naïve chronic hepatitis B: a comparison of efficacy and safety

Kim DY, Kim JH, Tak WY, Yeon JE, Lee JH, Yoon JH, Lee YJ, Lee BS, Han BH, Lee HC

Drug Design, Development and Therapy 2017, 11:3145-3152

Published Date: 31 October 2017

Severe eosinophilic asthma: from the pathogenic role of interleukin-5 to the therapeutic action of mepolizumab

Pelaia C, Vatrella A, Busceti MT, Gallelli L, Terracciano R, Savino R, Pelaia G

Drug Design, Development and Therapy 2017, 11:3137-3144

Published Date: 30 October 2017

Vitamin D levels in systemic sclerosis patients: a meta-analysis

An L, Sun M, Chen F, Li J

Drug Design, Development and Therapy 2017, 11:3119-3125

Published Date: 27 October 2017

High-dose dexamethasone induced LPS-stimulated rat alveolar macrophages apoptosis

Zeng S, Qiao H, Lv XW, Fan D, Liu T, Xie D

Drug Design, Development and Therapy 2017, 11:3097-3104

Published Date: 25 October 2017

Enhanced antitumor efficacy of poly(D,L-lactide-co-glycolide)-based methotrexate-loaded implants on sarcoma 180 tumor-bearing mice

Gao L, Xia L, Zhang R, Duan D, Liu X, Xu J, Luo L

Drug Design, Development and Therapy 2017, 11:3065-3075

Published Date: 20 October 2017

10H-3,6-Diazaphenothiazine induces G2/M phase cell cycle arrest and caspase-dependent apoptosis and inhibits cell invasion of A2780 ovarian carcinoma cells through the regulation of NF-κB and (BIRC6-XIAP) complexes

Zhang J, Ming C, Zhang W, Okechukwu PN, Morak-Młodawska B, Pluta K, Jeleń M, Akim AM, Ang KP, Ooi KK

Drug Design, Development and Therapy 2017, 11:3045-3063

Published Date: 24 October 2017

Failure mode and effects analysis drastically reduced potential risks in clinical trial conduct

Lee H, Lee H, Baik J, Kim HJ, Kim R

Drug Design, Development and Therapy 2017, 11:3035-3043

Published Date: 19 October 2017

Edaravone inhibits pressure overload-induced cardiac fibrosis and dysfunction by reducing expression of angiotensin II AT1 receptor

Zhang WW, Bai F, Wang J, Zheng RH, Yang LW, James EA, Zhao ZQ

Drug Design, Development and Therapy 2017, 11:3019-3033

Published Date: 16 October 2017

Amelioration of collagen-induced arthritis using antigen-loaded dendritic cells modified with NF-κB decoy oligodeoxynucleotides

Jiang HM, Hu HG, Zhang YL, Yue P, Ning LC, Zhou Y, Shi P, Yuan R

Drug Design, Development and Therapy 2017, 11:2997-3007

Published Date: 13 October 2017

5H-benzo[h]thiazolo[2,3-b]quinazolines ameliorate NDEA-induced hepatocellular carcinogenesis in rats through IL-6 downregulation along with oxidative and metabolic stress reduction

Keshari AK, Singh AK, Kumar U, Raj V, Rai A, Kumar P, Kumar D, Maity B, Nath S, Prakash A, Saha S

Drug Design, Development and Therapy 2017, 11:2981-2995

Published Date: 13 October 2017

Protective effect of DA-9401 in finasteride-induced apoptosis in rat testis: inositol requiring kinase 1 and c-Jun N-terminal kinase pathway

Soni KK, Shin YS, Choi BR, Karna KK, Kim HK, Lee SW, Kim CY, Park JK

Drug Design, Development and Therapy 2017, 11:2969-2979

Published Date: 11 October 2017

Halofuginone ameliorates inflammation in severe acute hepatitis B virus (HBV)-infected SD rats through AMPK activation

Zhan WL, Kang YH, Chen N, Mao CS, Kang Y, Shang J

Drug Design, Development and Therapy 2017, 11:2947-2955

Published Date: 10 October 2017

Short vs prolonged dual antiplatelet treatment upon endovascular stenting of peripheral arteries

Kronlage M, Wassmann M, Vogel B, Müller OJ, Blessing E, Katus H, Erbel C

Drug Design, Development and Therapy 2017, 11:2937-2945

Published Date: 6 October 2017

Spotlight on ertugliflozin and its potential in the treatment of type 2 diabetes: evidence to date

Cinti F, Moffa S, Impronta F, Cefalo CMA, Sun VA, Sorice GP, Mezza T, Giaccari A

Drug Design, Development and Therapy 2017, 11:2905-2919

Published Date: 3 October 2017

Current perspective on rituximab in rheumatic diseases

Schioppo T, Ingegnoli F

Drug Design, Development and Therapy 2017, 11:2891-2904

Published Date: 3 October 2017

The new era of nanotechnology, an alternative to change cancer treatment

Jurj A, Braicu C, Pop LA, Tomuleasa C, Gherman CD, Berindan-Neagoe I

Drug Design, Development and Therapy 2017, 11:2871-2890

Published Date: 27 September 2017

Downregulation of A20 increases the cytotoxicity of IFN-γ in hepatocellular carcinoma cells

Yin L, Fang Z, Shen N, Qiu Y, Li A, Zhang Y

Drug Design, Development and Therapy 2017, 11:2841-2850

Published Date: 26 September 2017

Eluxadoline in the treatment of diarrhea-predominant irritable bowel syndrome

Özdener AE, Rivkin A

Drug Design, Development and Therapy 2017, 11:2827-2840

Published Date: 26 September 2017

Axitinib in the treatment of renal cell carcinoma: design, development, and place in therapy

Bellesoeur A, Carton E, Alexandre J, Goldwasser F, Huillard O

Drug Design, Development and Therapy 2017, 11:2801-2811

Published Date: 21 September 2017

Dexmedetomidine reduces the neuronal apoptosis related to cardiopulmonary bypass by inhibiting activation of the JAK2–STAT3 pathway

Chen Y, Zhang X, Zhang B, He G, Zhou L, Xie Y

Drug Design, Development and Therapy 2017, 11:2787-2799

Published Date: 26 September 2017

Biodegradable rifampicin-releasing coating of surgical meshes for the prevention of bacterial infections

Reinbold J, Hierlemann T, Urich L, Uhde AK, Müller I, Weindl T, Vogel U, Schlensak C, Wendel HP, Krajewski S

Drug Design, Development and Therapy 2017, 11:2753-2762

Published Date: 18 September 2017

The roles of epigallocatechin-3-gallate in the treatment of neuropathic pain: an update on preclinical in vivo studies and future perspectives

Bimonte S, Cascella M, Schiavone V, Mehrabi-Kermani F, Cuomo A

Drug Design, Development and Therapy 2017, 11:2737-2742

Published Date: 13 September 2017

Pharmacokinetic and safety evaluation of MB12066, an NQO1 substrate

Lee HW, Seong SJ, Ohk B, Kang WY, Gwon MR, Kim BK, Kim HJ, Yoon YR

Drug Design, Development and Therapy 2017, 11:2719-2725

Published Date: 13 September 2017

Localized neuropathic pain: an expert consensus on local treatments

Pickering G, Martin E, Tiberghien F, Delorme C, Mick G

Drug Design, Development and Therapy 2017, 11:2709-2718

Published Date: 13 September 2017

Metal organic frameworks as a drug delivery system for flurbiprofen

AL Haydar M, Abid HR, Sunderland B, Wang S

Drug Design, Development and Therapy 2017, 11:2685-2695

Published Date: 11 September 2017

Cissus quadrangularis inhibits IL-1β induced inflammatory responses on chondrocytes and alleviates bone deterioration in osteotomized rats via p38 MAPK signaling [Corrigendum]

Kanwar JR, Samarasinghe RM, Kumar K, Arya R, Sanjeev S, Zhou SF, Sasidharan S, Kanwar RK

Drug Design, Development and Therapy 2017, 11:2683-2684

Published Date: 12 September 2017

Extended infusion versus intermittent infusion of imipenem in the treatment of ventilator-associated pneumonia

Ibrahim MM, Tammam TF, Ebaed MED, Sarhan HA, Gad GF, Hussein AK

Drug Design, Development and Therapy 2017, 11:2677-2682

Published Date: 6 September 2017

Palatability and physical properties of potassium-binding resin RDX7675: comparison with sodium polystyrene sulfonate

Zann V, McDermott J, Jacobs JW, Davidson JP, Lin F, Korner P, Blanks RC, Rosenbaum DP

Drug Design, Development and Therapy 2017, 11:2663-2673

Published Date: 6 September 2017

In vitro inhibitory activities of magnolol against Candida spp.

Zhou PR, Fu JY, Hua H, Liu XS

Drug Design, Development and Therapy 2017, 11:2653-2661

Published Date: 6 September 2017

Radium 223 dichloride for prostate cancer treatment

Deshayes E, Roumiguie M, Thibault C, Beuzeboc P, Cachin F, Hennequin C, Huglo D, Rozet F, Kassab-Chahmi D, Rebillard X, Houédé N

Drug Design, Development and Therapy 2017, 11:2643-2651

Published Date: 6 September 2017

Recent developments in the clinical pharmacology of rolapitant: subanalyses in specific populations

Rapoport BL, Aapro M, Chasen MR, Jordan K, Navari RM, Schnadig I, Schwartzberg L

Drug Design, Development and Therapy 2017, 11:2621-2629

Published Date: 5 September 2017

Protective role of quercetin against manganese-induced injury in the liver, kidney, and lung; and hematological parameters in acute and subchronic rat models

Bahar E, Lee GH, Bhattarai KR, Lee HY, Kim HK, Handigund M, Choi MK, Han SY, Chae HJ, Yoon H

Drug Design, Development and Therapy 2017, 11:2605-2619

Published Date: 5 September 2017

Puerarin transport across rat nasal epithelial cells and the influence of compatibility with paeoniflorin and menthol

Zhang L, Du S, Lu Y, Liu C, Wu H, Tian Z, Wang M, Yang C

Drug Design, Development and Therapy 2017, 11:2581-2593

Published Date: 1 September 2017

Quantum mechanics implementation in drug-design workflows: does it really help?

Arodola OA, Soliman MES

Drug Design, Development and Therapy 2017, 11:2551-2564

Published Date: 31 August 2017

New insight into the pathogenesis of nail psoriasis and overview of treatment strategies

Ventura A, Mazzeo M, Gaziano R, Galluzzo M, Bianchi L, Campione E

Drug Design, Development and Therapy 2017, 11:2527-2535

Published Date: 30 August 2017

Secondary prevention of major cerebrovascular events with seven different statins: a multi-treatment meta-analysis

Zhong P, Wu D, Ye X, Wu Y, Li T, Tong S, Liu X

Drug Design, Development and Therapy 2017, 11:2517-2526

Published Date: 30 August 2017

Therapy with pamidronate in children with osteogenesis imperfecta

Marginean O, Tamasanu RC, Mang N, Mozos I, Brad GF

Drug Design, Development and Therapy 2017, 11:2507-2515

Published Date: 28 August 2017

Advances in the delivery of buprenorphine for opioid dependence

Rosenthal RN, Goradia VV

Drug Design, Development and Therapy 2017, 11:2493-2505

Published Date: 28 August 2017

Paeoniflorin suppresses pancreatic cancer cell growth by upregulating HTRA3 expression

Li YJ, Gong LL, Qi RL, Sun Q, Xia XX, He HH, Ren JS, Zhu ON, Zhuo DB

Drug Design, Development and Therapy 2017, 11:2481-2491

Published Date: 23 August 2017

Preliminary study of nanonized lamotrigine containing products for nasal powder formulation

Gieszinger P, Csóka I, Pallagi E, Katona G, Jójárt-Laczkovich O, Szabó-Révész P, Ambrus R

Drug Design, Development and Therapy 2017, 11:2453-2466

Published Date: 23 August 2017

Aceclofenac nanocrystals with enhanced in vitro, in vivo performance: formulation optimization, characterization, analgesic and acute toxicity studies

Rahim H, Sadiq A, Khan S, Khan MA, Shah SMH, Hussain Z, Ullah R, Shahat AA, Ibrahim K

Drug Design, Development and Therapy 2017, 11:2443-2452

Published Date: 23 August 2017

Sensitization of gastric cancer cells to alkylating agents by glaucocalyxin B via cell cycle arrest and enhanced cell death

Ur Rahman MS, Zhang L, Wu LY, Xie YQ, Li CC, Cao J

Drug Design, Development and Therapy 2017, 11:2431-2441

Published Date: 22 August 2017

Metformin: a review of its potential indications

Wang YW, He SJ, Feng X, Cheng J, Luo YT, Tian L, Huang Q

Drug Design, Development and Therapy 2017, 11:2421-2429

Published Date: 22 August 2017

Pomalidomide in the treatment of multiple myeloma: design, development and place in therapy

Rios-Tamayo R, Martín-García A, Alarcón-Payer C, Sánchez-Rodríguez D, Guardia AM, García Collado CG, Jiménez Morales A, Jurado Chacón M, Cabeza Barrera J

Drug Design, Development and Therapy 2017, 11:2399-2408

Published Date: 22 August 2017

Onychomadesis associated with chemotherapy: case report and mini literature review

Li A, Li Y, Ge L, Li P, Li W

Drug Design, Development and Therapy 2017, 11:2373-2376

Published Date: 14 August 2017

Widening use of dexamethasone implant for the treatment of macular edema

Bonfiglio V, Reibaldi M, Fallico M, Russo A, Pizzo A, Fichera S, Rapisarda C, Macchi I, Avitabile T, Longo A

Drug Design, Development and Therapy 2017, 11:2359-2372

Published Date: 16 August 2017

Microbial challenge test of a novel epoprostenol sodium formulation

Bandilla D, Goverde M, Giudici P, Lambert O

Drug Design, Development and Therapy 2017, 11:2347-2357

Published Date: 10 August 2017

Isatin-benzoazine molecular hybrids as potential antiproliferative agents: synthesis and in vitro pharmacological profiling

Abdel-Aziz HA, Eldehna WM, Keeton AB, Piazza GA, Kadi AA, Attwa MW, Abdelhameed AS, Attia MI

Drug Design, Development and Therapy 2017, 11:2333-2346

Published Date: 9 August 2017

Modeling the human Nav1.5 sodium channel: structural and mechanistic insights of ion permeation and drug blockade

Ahmed M, Jalily Hasani H, Ganesan A, Houghton M, Barakat K

Drug Design, Development and Therapy 2017, 11:2301-2324

Published Date: 4 August 2017

Safety of switching from brand-name to generic levetiracetam in patients with epilepsy

Bosak M, Słowik A, Turaj W

Drug Design, Development and Therapy 2017, 11:2287-2291

Published Date: 3 August 2017

Intracellular trafficking of new anticancer therapeutics: antibody–drug conjugates

Kalim M, Chen J, Wang S, Lin C, Ullah S, Liang K, Ding Q, Chen S, Zhan JB

Drug Design, Development and Therapy 2017, 11:2265-2276

Published Date: 2 August 2017

Markers of oxidative/nitrosative stress and inflammation in lung tissue of rats exposed to different intravenous iron compounds

Toblli JE, Cao G, Giani JF, Dominici FP, Angerosa M

Drug Design, Development and Therapy 2017, 11:2251-2263

Published Date: 1 August 2017

Comparative analysis of essential oil composition of Iranian and Indian Nigella sativa L. extracted using supercritical fluid extraction and solvent extraction

Ghahramanloo KH, Kamalidehghan B, Akbari Javar H, Teguh Widodo R, Majidzadeh K, Noordin MI

Drug Design, Development and Therapy 2017, 11:2221-2226

Published Date: 28 July 2017

Antibiotic susceptibility, heteroresistance, and updated treatment strategies in Helicobacter pylori infection

Mascellino MT, Porowska B, De Angelis M, Oliva A

Drug Design, Development and Therapy 2017, 11:2209-2220

Published Date: 28 July 2017

Schisandrin B attenuates CCl4-induced liver fibrosis in rats by regulation of Nrf2-ARE and TGF-β/Smad signaling pathways

Chen QS, Zhang H, Cao Y, Li Y, Sun S, Zhang JP, Zhang GQ

Drug Design, Development and Therapy 2017, 11:2179-2191

Published Date: 26 July 2017

The modulation of enzyme indoleamine 2,3-dioxygenase from dendritic cells for the treatment of type 1 diabetes mellitus

Abram DM, Fernandes LGR, Ramos Filho ACS, Simioni PU

Drug Design, Development and Therapy 2017, 11:2171-2178

Published Date: 24 July 2017

Using dezocine to prevent etomidate-induced myoclonus: a meta-analysis of randomized trials

Zhu Y, Yang Y, Zhou C, Bao Z

Drug Design, Development and Therapy 2017, 11:2163-2170

Published Date: 18 July 2017

Efficacy and safety of direct-acting antiviral therapy in previous hard-to-treat patients with recurrent hepatitis C virus infection after liver transplantation: a real-world cohort

Bernuth S, Grimm D, Vollmar J, Darstein F, Mittler J, Heise M, Hoppe-Lotichius M, Galle PR, Lang H, Zimmermann T

Drug Design, Development and Therapy 2017, 11:2131-2138

Published Date: 12 July 2017

Clinical utility of evolocumab in the management of hyperlipidemia: patient selection and follow-up

Dixon DL, Buckley LF, Trankle CR, Kadariya D, Abbate A

Drug Design, Development and Therapy 2017, 11:2121-2129

Published Date: 11 July 2017

Evaluation of the stability of linezolid in aqueous solution and commonly used intravenous fluids

Taylor R, Sunderland B, Luna G, Czarniak P

Drug Design, Development and Therapy 2017, 11:2087-2097

Published Date: 10 July 2017

Spotlight on ceritinib in the treatment of ALK+ NSCLC: design, development and place in therapy

Santarpia M, Daffinà MG, D'Aveni A, Marabello G, Liguori A, Giovannetti E, Karachaliou N, Gonzalez Cao M, Rosell R, Altavilla G

Drug Design, Development and Therapy 2017, 11:2047-2063

Published Date: 5 July 2017

Development of highly potent melanogenesis inhibitor by in vitro, in vivo and computational studies

Abbas Q, Ashraf Z, Hassan M, Nadeem H, Latif M, Afzal S, Seo S

Drug Design, Development and Therapy 2017, 11:2029-2046

Published Date: 5 July 2017

Synthesis and antimicrobial activity of chiral quaternary N-spiro ammonium bromides with 3',4'-dihydro-1'H-spiro[isoindoline-2,2'-isoquinoline] skeleton

Bielawski K, Leszczyńska K, Kałuża Z, Bielawska A, Michalak O, Daniluk T, Staszewska-Krajewska O, Czajkowska A, Pawłowska N, Gornowicz A

Drug Design, Development and Therapy 2017, 11:2015-2028

Published Date: 5 July 2017

Targeted therapy in severe asthma today: focus on immunoglobulin E

Pelaia G, Canonica GW, Matucci A, Paolini R, Triggiani M, Paggiaro P

Drug Design, Development and Therapy 2017, 11:1979-1987

Published Date: 29 June 2017

Cell and small animal models for phenotypic drug discovery

Szabo M, Svensson Akusjärvi S, Saxena A, Liu J, Chandrasekar G, Kitambi SS

Drug Design, Development and Therapy 2017, 11:1957-1967

Published Date: 28 June 2017

Determining optimal dosing regimen of oral administration of dicloxacillin using Monte Carlo simulation

Yu W, Ji J, Xiao T, Ying C, Fang J, Shen P, Xiao Y

Drug Design, Development and Therapy 2017, 11:1951-1956

Published Date: 28 June 2017

Comparison of neurotoxic potency between a novel chinbotulinumtoxinA with onabotulinumtoxinA, incobotulinumtoxinA and lanbotulinumtoxinA in rats

Feng Y, Liu WC, Pan LZ, Jiang C, Zhang CX, Lu YX, Nie ZY, Jin LJ

Drug Design, Development and Therapy 2017, 11:1927-1939

Published Date: 28 June 2017

Effect of picroside II on hind limb ischemia reperfusion injury in rats

Kılıç Y, Özer A, Tatar T, Zor MH, Kirişçi M, Kartal H, Dursun AD, Billur D, Arslan M, Küçük A

Drug Design, Development and Therapy 2017, 11:1917-1925

Published Date: 26 June 2017

Antiglioma effects of cytarabine on leptomeningeal metastasis of high-grade glioma by targeting the PI3K/Akt/mTOR pathway

Zhao KH, Zhang C, Bai Y, Li Y, Kang X, Chen JX, Yao K, Jiang T, Zhong XS, Li WB

Drug Design, Development and Therapy 2017, 11:1905-1915

Published Date: 26 June 2017

Efficacy and safety of retinol palmitate ophthalmic solution in the treatment of dry eye: a Japanese Phase II clinical trial

Toshida H, Funaki T, Ono K, Tabuchi N, Watanabe S, Seki T, Otake H, Kato T, Ebihara N, Murakami A

Drug Design, Development and Therapy 2017, 11:1871-1879

Published Date: 23 June 2017

Molecular docking, QSAR and ADMET studies of withanolide analogs against breast cancer

Yadav DK, Kumar S, Saloni, Singh H, Kim M, Sharma P, Misra S, Khan F

Drug Design, Development and Therapy 2017, 11:1859-1870

Published Date: 22 June 2017

Differential effect of platelet-rich plasma fractions on β1-integrin signaling, collagen biosynthesis, and prolidase activity in human skin fibroblasts

Guszczyn T, Surażyński A, Zaręba I, Rysiak E, Popko J, Pałka J

Drug Design, Development and Therapy 2017, 11:1849-1857

Published Date: 22 June 2017

Enzymatic synthesis and in vitro evaluation of folate-functionalized liposomes

Guo B, Xu D, Liu X, Yi J

Drug Design, Development and Therapy 2017, 11:1839-1847

Published Date: 20 June 2017

Comparison of posttransplant outcomes in patients with no, acute, or chronic amiodarone use before heart transplantation

Rivinius R, Helmschrott M, Ruhparwar A, Darche FF, Thomas D, Bruckner T, Katus HA, Doesch AO

Drug Design, Development and Therapy 2017, 11:1827-1837

Published Date: 19 June 2017

Cryptotanshinone induces cell cycle arrest and apoptosis through the JAK2/STAT3 and PI3K/Akt/NFkB pathways in cholangiocarcinoma cells

Ke FY, Wang Z, Song XL, Ma Q, Hu YP, Jiang L, Zhang YJ, Liu YB, Zhang Y, Gong W

Drug Design, Development and Therapy 2017, 11:1753-1766

Published Date: 15 June 2017

Controlled release of optimized electroporation enhances the transdermal efficiency of sinomenine hydrochloride for treating arthritis in vitro and in clinic

Feng S, Zhu L, Huang Z, Wang H, Li H, Zhou H, Lu L, Wang Y, Liu Z, Liu L

Drug Design, Development and Therapy 2017, 11:1737-1752

Published Date: 15 June 2017

Efficacy of antibiotic treatment of implant-associated Staphylococcus aureus infections with moxifloxacin, flucloxacillin, rifampin, and combination therapy: an animal study

Greimel F, Scheuerer C, Gessner A, Simon M, Kalteis T, Grifka J, Benditz A, Springorum HR, Schaumburger J

Drug Design, Development and Therapy 2017, 11:1729-1736

Published Date: 14 June 2017

Lugano 2014 criteria for assessing FDG-PET/CT in lymphoma: an operational approach for clinical trials

Van Heertum RL, Scarimbolo R, Wolodzko JG, Klencke B, Messmann R, Tunc F, Sokol L, Agarwal R, Strafaci JA, O'Neal M

Drug Design, Development and Therapy 2017, 11:1719-1728

Published Date: 13 June 2017

Controlled-release nanoencapsulating microcapsules to combat inflammatory diseases

Baek JS, Yeo EW, Lee YH, Tan NS, Loo SCJ

Drug Design, Development and Therapy 2017, 11:1707-1717

Published Date: 8 June 2017

Development of new promising antimetabolite, DFP-11207 with self-controlled toxicity in rodents

Fukushima M, Iizuka K, Jin C, Zhang C, Hong M, Eshima K

Drug Design, Development and Therapy 2017, 11:1693-1705

Published Date: 7 June 2017

Renal function in heart transplant patients after switch to combined mammalian target of rapamycin inhibitor and calcineurin inhibitor therapy

Helmschrott M, Rivinius R, Bruckner T, Katus HA, Doesch AO

Drug Design, Development and Therapy 2017, 11:1673-1680

Published Date: 7 June 2017

Rhein attenuates inflammation through inhibition of NF-κB and NALP3 inflammasome in vivo and in vitro

Ge H, Tang H, Liang Y, Wu J, Yang Q, Zeng L, Ma Z

Drug Design, Development and Therapy 2017, 11:1663-1671

Published Date: 6 June 2017

CT-P13: design, development, and place in therapy

Gabbani T, Deiana S, Annese V

Drug Design, Development and Therapy 2017, 11:1653-1661

Published Date: 6 June 2017

Spotlight on ixekizumab for the treatment of moderate-to-severe plaque psoriasis: design, development, and use in therapy

Giunta A, Ventura A, Chimenti MS, Bianchi L, Esposito M

Drug Design, Development and Therapy 2017, 11:1643-1651

Published Date: 2 June 2017

Development of antiproliferative long-circulating liposomes co-encapsulating doxorubicin and curcumin, through the use of a quality-by-design approach

Tefas LR, Sylvester B, Tomuta I, Sesarman A, Licarete E, Banciu M, Porfire A

Drug Design, Development and Therapy 2017, 11:1605-1621

Published Date: 25 May 2017

Profile of sarilumab and its potential in the treatment of rheumatoid arthritis

Raimondo MG, Biggioggero M, Crotti C, Becciolini A, Favalli EG

Drug Design, Development and Therapy 2017, 11:1593-1603

Published Date: 24 May 2017

Effect of a food supplement containing berberine, monacolin K, hydroxytyrosol and coenzyme Q10 on lipid levels: a randomized, double-blind, placebo controlled study

D'Addato S, Scandiani L, Mombelli G, Focanti F, Pelacchi F, Salvatori E, Di Loreto G, Comandini A, Maffioli P, Derosa G

Drug Design, Development and Therapy 2017, 11:1585-1592

Published Date: 23 May 2017

Past and current perspective on new therapeutic targets for Type-II diabetes

Patil PD, Mahajan UB, Patil KR, Chaudhari S, Patil CR, Agrawal YO, Ojha S, Goyal SN

Drug Design, Development and Therapy 2017, 11:1567-1583

Published Date: 22 May 2017

Outcome of stroke patients receiving different doses of recombinant tissue plasminogen activator

Ong CT, Wong YS, Wu CS, Su YH

Drug Design, Development and Therapy 2017, 11:1559-1566

Published Date: 18 May 2017

Cisplatin induces protective autophagy through activation of BECN1 in human bladder cancer cells

Lin JF, Lin YC, Tsai TF, Chen HE, Chou KY, Hwang TIS

Drug Design, Development and Therapy 2017, 11:1517-1533

Published Date: 16 May 2017

Ten years of biosimilars in Europe: development and evolution of the regulatory pathways

Schiestl M, Zabransky M, Sörgel F

Drug Design, Development and Therapy 2017, 11:1509-1515

Published Date: 16 May 2017

Ten years of clinical experience with biosimilar human growth hormone: a review of safety data

Borrás Pérez MV, Kriström B, Romer T, Walczak M, Höbel N, Zabransky M

Drug Design, Development and Therapy 2017, 11:1497-1503

Published Date: 16 May 2017

Ten years' clinical experience with biosimilar human growth hormone: a review of efficacy data

López-Siguero JP, Pfäffle R, Chanson P, Szalecki M, Höbel N, Zabransky M

Drug Design, Development and Therapy 2017, 11:1489-1495

Published Date: 16 May 2017

Fabrication, characterization and in vitro evaluation of silibinin nanoparticles: an attempt to enhance its oral bioavailability

Sahibzada MUK, Sadiq A, Khan S, Faidah HS, Naseemullah, Khurram M, Amin MU, Haseeb A

Drug Design, Development and Therapy 2017, 11:1453-1464

Published Date: 15 May 2017

Preparation, characterization, and in vitro/vivo studies of oleanolic acid-loaded lactoferrin nanoparticles

Xia X, Liu H, Lv H, Zhang J, Zhou JP, Zhao Z

Drug Design, Development and Therapy 2017, 11:1417-1427

Published Date: 9 May 2017

Effect of epigallocatechin-3-gallate, major ingredient of green tea, on the pharmacokinetics of rosuvastatin in healthy volunteers

Kim TE, Ha N, Kim Y, Kim H, Lee JW, Jeon JY, Kim MG

Drug Design, Development and Therapy 2017, 11:1409-1416

Published Date: 9 May 2017

Propranolol therapy for infantile hemangioma: our experience

Zhang L, Wu HW, Yuan W, Zheng J

Drug Design, Development and Therapy 2017, 11:1401-1408

Published Date: 8 May 2017

Involvement of NF-κB and HSP70 signaling pathways in the apoptosis of MDA-MB-231 cells induced by a prenylated xanthone compound, α-mangostin, from Cratoxylum arborescens [Retraction]

Ibrahim MY, Hashim NM, Mohan S, Abdulla MA, Abdelwahab SI, Kamalidehghan B, Ghaderian M, Dehghan F, Ali LZ, Karimian H, Yahayu M, Ee GCL, Farjam AS, Ali HM

Drug Design, Development and Therapy 2017, 11:1399-1400

Published Date: 12 May 2017

Effect of electromagnetic fields and antioxidants on the trace element content of rat teeth

Dogan MS, Yavas MC, Yavuz Y, Erdogan S, Yener İ, Simsek İ, Akkus Z, Eratilla V, Tanik A, Akdag MZ

Drug Design, Development and Therapy 2017, 11:1393-1398

Published Date: 4 May 2017

Atorvastatin, a double weapon in osteoporosis treatment: an experimental and clinical study

El-Nabarawy N, El-Wakd M, Salem M

Drug Design, Development and Therapy 2017, 11:1383-1391

Published Date: 2 May 2017

Developing selective histone deacetylases (HDACs) inhibitors through ebselen and analogs

Wang Y, Wallach J, Duane S, Wang Y, Wu J, Wang J, Adejare A, Ma H

Drug Design, Development and Therapy 2017, 11:1369-1382

Published Date: 2 May 2017

Combined letrozole and clomiphene versus letrozole and clomiphene alone in infertile patients with polycystic ovary syndrome [Erratum]

Ghasemi-Rad M, Hajishafiha M, Dehghan M, Sadegh-Asadi N, Navid Shayegh S, Kiarang N

Drug Design, Development and Therapy 2017, 11:1367-1368

Published Date: 28 April 2017

Methanol leaf extract of Actinodaphne sesquipedalis (Lauraceae) enhances gastric defense against ethanol-induced ulcer in rats

Omar H, Nordin N, Hassandarvish P, Hajrezaie M, Azizan AHS, Fadaeinasab M, Abdul Majid N, Abdulla MA, Mohd Hashim N, Mohd Ali H

Drug Design, Development and Therapy 2017, 11:1353-1365

Published Date: 4 May 2017

Evaluation of the antitumor activity of NOV202, a novel microtubule targeting and vascular disrupting agent

Rickardson L, Kutvonen E, Orasniemi S, Högberg M, Kallio MJ, Rehnmark S

Drug Design, Development and Therapy 2017, 11:1335-1351

Published Date: 28 April 2017

Development and evaluation of a new modular nanotransporter for drug delivery into nuclei of pathological cells expressing folate receptors

Slastnikova TA, Rosenkranz AA, Khramtsov YV, Karyagina TS, Ovechko SA, Sobolev AS

Drug Design, Development and Therapy 2017, 11:1315-1334

Published Date: 26 April 2017

A first-in-human, double-blind, placebo-controlled, randomized, dose escalation study of DWP05195, a novel TRPV1 antagonist, in healthy volunteers

Lee J, Kim BH, Yu KS, Kim HS, Kim JD, Cho JY, Lee S, Gu N

Drug Design, Development and Therapy 2017, 11:1301-1313

Published Date: 24 April 2017

Proton-pump inhibitors use, and risk of acute kidney injury: a meta-analysis of observational studies

Yang Y, George KC, Shang WF, Zeng R, Ge SW, Xu G

Drug Design, Development and Therapy 2017, 11:1291-1299

Published Date: 24 April 2017

Functional characterization of wild-type and 24 CYP2D6 allelic variants on gefitinib metabolism in vitro

Fang P, Zheng X, He JY, Ge HL, Tang PF, Cai JP, Hu GX

Drug Design, Development and Therapy 2017, 11:1283-1290

Published Date: 21 April 2017

Anti-platelet effects of anti-glaucomatous eye drops: an in vitro study on human platelets

Moschos MM, Moustafa GA, Papakonstantinou VD, Tsatsos M, Laios K, Antonopoulou S

Drug Design, Development and Therapy 2017, 11:1267-1272

Published Date: 19 April 2017

Humanin rescues cultured rat cortical neurons from NMDA-induced toxicity through the alleviation of mitochondrial dysfunction

Cui A, Zhang Y, Li J, Song T, Liu X, Wang H, Zhang C, Ma G, Zhang H, Li K

Drug Design, Development and Therapy 2017, 11:1243-1253

Published Date: 18 April 2017

A comparative study on endovascular treatment of (sub)acute critical limb ischemia: mechanical thrombectomy vs thrombolysis

Kronlage M, Printz I, Vogel B, Blessing E, Müller OJ, Katus HA, Erbel C

Drug Design, Development and Therapy 2017, 11:1233-1241

Published Date: 18 April 2017

Vitamin D deficiency and tuberculosis: what about body mass index?

Hernández-Garduño E

Drug Design, Development and Therapy 2017, 11:1193-1194

Published Date: 11 April 2017

Bioequivalence study of a new sildenafil 100 mg orodispersible film compared to the conventional film-coated 100 mg tablet administered to healthy male volunteers

Radicioni M, Castiglioni C, Giori A, Cupone I, Frangione V, Rovati S

Drug Design, Development and Therapy 2017, 11:1183-1192

Published Date: 11 April 2017

Justification of disintegration testing beyond current FDA criteria using in vitro and in silico models

Uebbing L, Klumpp L, Webster GK, Löbenberg R

Drug Design, Development and Therapy 2017, 11:1163-1174

Published Date: 11 April 2017

Relaxin inhibits cardiac fibrosis and endothelial–mesenchymal transition via the Notch pathway [Corrigendum]

Zhou X, Chen X, Cai JJ, Chen LZ, Gong YS, Wang LX, Gao Z, Zhang HQ, Huang WJ, Zhou H

Drug Design, Development and Therapy 2017, 11:1159-1160

Published Date: 10 April 2017

Investigation of triamterene as an inhibitor of the TGR5 receptor: identification in cells and animals

Li Y, Cheng KC, Niu C, Lo S, Cheng JT, Niu H

Drug Design, Development and Therapy 2017, 11:1127-1134

Published Date: 5 April 2017

Phenotypic evaluation and in silico ADMET properties of novel arylimidamides in acute mouse models of Trypanosoma cruzi infection

da Silva CF, Batista DDGJ, de Araújo JS, Cunha-Junior EF, Stephens CE, Banerjee M, Farahat AA, Akay S, Fisher MK, Boykin DW, Soeiro MDNC

Drug Design, Development and Therapy 2017, 11:1095-1105

Published Date: 3 April 2017

Formulation, release characteristics, and bioavailability study of gastroretentive floating matrix tablet and floating raft system of Mebeverine HCl

El Nabarawi MA, Teaima MH, Abd El-Monem RA, El Nabarawy NA, Gaber DA

Drug Design, Development and Therapy 2017, 11:1081-1093

Published Date: 3 April 2017

Drug–drug interaction of microdose and regular-dose omeprazole with a CYP2C19 inhibitor and inducer

Park G, Bae SH, Park W, Han S, Park M, Shin S, Shin YG, Yim DS

Drug Design, Development and Therapy 2017, 11:1043-1053

Published Date: 30 March 2017

Mirtazapine for symptom control in refractory gastroparesis

Malamood M, Roberts A, Kataria R, Parkman HP, Schey R

Drug Design, Development and Therapy 2017, 11:1035-1041

Published Date: 30 March 2017

Rutin protects against neuronal damage in vitro and ameliorates doxorubicin-induced memory deficits in vivo in Wistar rats

Ramalingayya GV, Cheruku SP, Nayak PG, Kishore A, Shenoy R, Rao CM, Krishnadas N

Drug Design, Development and Therapy 2017, 11:1011-1026

Published Date: 29 March 2017

The antiulcer effect of Cibotium barometz leaves in rats with experimentally induced acute gastric ulcer

AL-Wajeeh NS, Hajrezaei M, Al-Henhena N, Kamran S, Bagheri E, Zahedifard M, Saremi K, Noor SM, Ali HM, Abdulla MA

Drug Design, Development and Therapy 2017, 11:995-1009

Published Date: 30 March 2017

An open randomized active-controlled clinical trial with low-dose SKA cytokines versus DMARDs evaluating low disease activity maintenance in patients with rheumatoid arthritis

Martin-Martin LS, Giovannangeli F, Bizzi E, Massafra U, Ballanti E, Cassol M, Migliore A

Drug Design, Development and Therapy 2017, 11:985-994

Published Date: 29 March 2017

Optimized formulation of multivesicular liposomes loaded with oleanolic acid enhanced anticancer effect in vitro

Wang Y, Luo Y, Li C, Zhang X, Pi C, Yu L, Wang S, Zhong Z

Drug Design, Development and Therapy 2017, 11:955-968

Published Date: 27 March 2017

Synergistic effects of antimicrobial peptide DP7 combined with antibiotics against multidrug-resistant bacteria

Wu X, Li Z, Li X, Tian Y, Fan Y, Yu C, Zhou B, Liu Y, Xiang R, Yang L

Drug Design, Development and Therapy 2017, 11:939-946

Published Date: 22 March 2017

Nanostructured lipid carriers for incorporation of copper(II) complexes to be used against Mycobacterium tuberculosis

Sato MR, Oshiro Junior JA, Machado RTA, de Souza PC, Campos DL, Pavan FR, da Silva PB, Chorilli M

Drug Design, Development and Therapy 2017, 11:909-921

Published Date: 20 March 2017

Clinical potential of SLAMF7 antibodies – focus on elotuzumab in multiple myeloma

Friend R, Bhutani M, Voorhees PM, Usmani SZ

Drug Design, Development and Therapy 2017, 11:893-900

Published Date: 20 March 2017

Delafloxacin: design, development and potential place in therapy

Candel FJ, Peñuelas M

Drug Design, Development and Therapy 2017, 11:881-891

Published Date: 20 March 2017

Artonin E induces p53-independent G1 cell cycle arrest and apoptosis through ROS-mediated mitochondrial pathway and livin suppression in MCF-7 cells

Etti IC, Rasedee A, Hashim NM, Abdul AB, Kadir A, Yeap SK, Waziri P, Malami I, Lim KL, Etti CJ

Drug Design, Development and Therapy 2017, 11:865-879

Published Date: 20 March 2017

Efficacy of cytokine-induced killer cell infusion as an adjuvant immunotherapy for hepatocellular carcinoma: a systematic review and meta-analysis

Yu R, Yang B, Chi X, Cai L, Liu C, Yang L, Wang X, He P, Lu X

Drug Design, Development and Therapy 2017, 11:851-864

Published Date: 17 March 2017

Cardioprotection with halogenated gases: how does it occur?

Guerrero-Orriach JL, Escalona Belmonte JJ, Ramirez Fernandez A, Ramirez Aliaga M, Rubio Navarro M, Cruz Mañas J

Drug Design, Development and Therapy 2017, 11:837-849

Published Date: 16 March 2017

Design, synthesis, and antimelanogenic effects of (2-substituted phenyl-1,3-dithiolan-4-yl)methanol derivatives

Kim DH, Kim SJ, Ullah S, Yun HY, Chun P, Moon HR

Drug Design, Development and Therapy 2017, 11:827-836

Published Date: 16 March 2017

Development of erythropoietin receptor-targeted drug delivery system against breast cancer using tamoxifen-loaded nanostructured lipid carriers

Beh CY, How CW, Foo JB, Foong JN, Selvarajah GT, Rasedee A

Drug Design, Development and Therapy 2017, 11:771-782

Published Date: 14 March 2017

Glycophenotype of breast and prostate cancer stem cells treated with thieno[2,3-b]pyridine anticancer compound

Mastelić A, Čikeš Čulić V, Režić Mužinić N, Vuica-Ross M, Barker D, Leung EY, Reynisson J, Markotić A

Drug Design, Development and Therapy 2017, 11:759-769

Published Date: 14 March 2017

An open-label, two-period comparative study on pharmacokinetics and safety of a combined ethinylestradiol/gestodene transdermal contraceptive patch

Zhang C, Li H, Xiong X, Zhai S, Wei Y, Zhang S, Zhang Y, Xu L, Liu L

Drug Design, Development and Therapy 2017, 11:725-731

Published Date: 10 March 2017

Pharmacokinetics and tolerability of DA-8031, a novel selective serotonin reuptake inhibitor for premature ejaculation in healthy male subjects

Shin D, Lee S, Yi S, Yoon SH, Cho JY, Bahng MY, Jang IJ, Yu KS

Drug Design, Development and Therapy 2017, 11:713-723

Published Date: 10 March 2017

Effects of dexamethasone coadministered with oseltamivir on the pharmacokinetics of oseltamivir in healthy volunteers

Jang K, Kim M, Oh J, Lee S, Cho JY, Yu KS, Choi TK, Lee SH, Lim KS

Drug Design, Development and Therapy 2017, 11:705-711

Published Date: 9 March 2017

Transcriptome analysis of endometrial tissues following GnRH agonist treatment in a mouse adenomyosis model

Guo S, Lu X, Gu R, Zhang D, Sun Y, Feng Y

Drug Design, Development and Therapy 2017, 11:695-704

Published Date: 9 March 2017

Development of venetoclax for therapy of lymphoid malignancies

Zhu H, Almasan A

Drug Design, Development and Therapy 2017, 11:685-694

Published Date: 9 March 2017

Does remifentanil attenuate renal ischemia–reperfusion injury better than dexmedetomidine in rat kidney?

Erkılıç E, Kesimci E, Alaybeyoğlu F, Kılınç I, Tural R, Yazgan A, Gümüş T, Sepici Dinçel A, Dumlu EG, Kanbak O

Drug Design, Development and Therapy 2017, 11:677-683

Published Date: 8 March 2017

Protective influence of hyaluronic acid on focal adhesion kinase activity in human skin fibroblasts exposed to ethanol

Donejko M, Rysiak E, Galicka E, Terlikowski R, Głażewska EK, Przylipiak A

Drug Design, Development and Therapy 2017, 11:669-676

Published Date: 6 March 2017

Paclitaxel-loaded star-shaped copolymer nanoparticles for enhanced malignant melanoma chemotherapy against multidrug resistance

Su Y, Hu J, Huang Z, Huang Y, Peng B, Xie N, Liu H

Drug Design, Development and Therapy 2017, 11:659-668

Published Date: 6 March 2017

New developments in the management of partial-onset epilepsy: role of brivaracetam

Coppola G, Iapadre G, Operto FF, Verrotti A

Drug Design, Development and Therapy 2017, 11:643-657

Published Date: 6 March 2017

MC-PPEA as a new and more potent inhibitor of CLP-induced sepsis and pulmonary inflammation than FK866

Huang P, Lee Jr MW, Sadrerafi K, Heruth DP, Zhang LQ, Maulik D, Ye SQ

Drug Design, Development and Therapy 2017, 11:629-641

Published Date: 3 March 2017

Metal complexes in cancer therapy – an update from drug design perspective

Ndagi U, Mhlongo N, Soliman ME

Drug Design, Development and Therapy 2017, 11:599-616

Published Date: 3 March 2017

Awake craniotomy anesthetic management using dexmedetomidine, propofol, and remifentanil

Prontera A, Baroni S, Marudi A, Valzania F, Feletti A, Benuzzi F, Bertellini E, Pavesi G

Drug Design, Development and Therapy 2017, 11:593-598

Published Date: 3 March 2017

Human papillomavirus (HPV): systemic treatment with Gene-Eden-VIR/Novirin safely and effectively clears virus

Polansky H, Itzkovitz E, Javaherian A

Drug Design, Development and Therapy 2017, 11:575-583

Published Date: 3 March 2017

In silico discovery and in vitro activity of inhibitors against Mycobacterium tuberculosis 7,8-diaminopelargonic acid synthase (Mtb BioA)

Billones JB, Carrillo MCO, Organo VG, Sy JBA, Clavio NAB, Macalino SJY, Emnacen IA, Lee AP, Ko PKL, Concepcion GP

Drug Design, Development and Therapy 2017, 11:563-574

Published Date: 2 March 2017

Adenosine A2A  receptor agonist prevents cardiac remodeling and dysfunction in spontaneously hypertensive male rats after myocardial infarction

da Silva JS, Gabriel-Costa D, Sudo RT, Wang H, Groban L, Ferraz EB, Nascimento JHM, Fraga CAM, Barreiro EJ, Zapata-Sudo G

Drug Design, Development and Therapy 2017, 11:553-562

Published Date: 6 March 2017

Defective DNA repair mechanisms in prostate cancer: impact of olaparib

De Felice F, Tombolini V, Marampon F, Musella A, Marchetti C

Drug Design, Development and Therapy 2017, 11:547-552

Published Date: 1 March 2017

Eteplirsen in the treatment of Duchenne muscular dystrophy

Lim KRQ, Maruyama R, Yokota T

Drug Design, Development and Therapy 2017, 11:533-545

Published Date: 28 February 2017

Sofosbuvir/velpatasvir regimen promises an effective pan-genotypic hepatitis C virus cure

Mir F, Kahveci AS, Ibdah JA, Tahan V

Drug Design, Development and Therapy 2017, 11:497-502

Published Date: 23 February 2017

Polyphosphoester nanoparticles as biodegradable platform for delivery of multiple drugs and siRNA

Elzeny H, Zhang F, Ali EN, Fathi HA, Zhang S, Li R, El-Mokhtar MA, Hamad MA, Wooley KL, Elsabahy M

Drug Design, Development and Therapy 2017, 11:483-496

Published Date: 22 February 2017

Antiproliferation effect of imatinib mesylate on MCF7, T-47D tumorigenic and MCF 10A nontumorigenic breast cell lines via PDGFR-β, PDGF-BB, c-Kit and SCF genes

Kadivar A, Kamalidehghan B, Akbari Javar H, Karimi B, Sedghi R, Noordin MI

Drug Design, Development and Therapy 2017, 11:469-481

Published Date: 21 February 2017

Insight into resistance mechanisms of AZD4547 and E3810 to FGFR1 gatekeeper mutation via theoretical study

Liang D, Chen Q, Guo Y, Zhang T, Guo W

Drug Design, Development and Therapy 2017, 11:451-461

Published Date: 17 February 2017

Reversal of multidrug resistance in human lung cancer cells by delivery of 3-octadecylcarbamoylacrylic acid–cisplatin-based liposomes

Song J, Ren W, Xu T, Zhang Y, Guo H, Zhu S, Yang L

Drug Design, Development and Therapy 2017, 11:441-449

Published Date: 17 February 2017

Curcumin induces apoptosis and protective autophagy in castration-resistant prostate cancer cells through iron chelation

Yang C, Ma X, Wang Z, Zeng X, Hu Z, Ye Z, Shen G

Drug Design, Development and Therapy 2017, 11:431-439

Published Date: 14 February 2017

Novel 5-oxo-hexahydroquinoline derivatives: design, synthesis, in vitro P-glycoprotein-mediated multidrug resistance reversal profile and molecular dynamics simulation study

Shahraki O, Edraki N, Khoshneviszadeh M, Zargari F, Ranjbar S, Saso L, Firuzi O, Miri R

Drug Design, Development and Therapy 2017, 11:407-418

Published Date: 14 February 2017

Oral and transdermal drug delivery systems: role of lipid-based lyotropic liquid crystals

Rajabalaya R, Musa MN, Kifli N, David SR

Drug Design, Development and Therapy 2017, 11:393-406

Published Date: 13 February 2017

Antioxidant compounds and activities of the stem, flower, and leaf extracts of the anti-smoking Thai medicinal plant: Vernonia cinerea Less

Ketsuwan N, Leelarungrayub J, Kothan S, Singhatong S

Drug Design, Development and Therapy 2017, 11:383-391

Published Date: 13 February 2017

Pharmacokinetics of conivaptan use in patients with severe hepatic impairment

Marbury T, Fox J, Kaelin B, Pavliv L

Drug Design, Development and Therapy 2017, 11:373-382

Published Date: 13 February 2017

Gancidin W, a potential low-toxicity antimalarial agent isolated from an endophytic Streptomyces SUK10

Zin NM, Baba MS, Zainal-Abidin AH, Latip J, Mazlan NW, Edrada-Ebel R

Drug Design, Development and Therapy 2017, 11:351-363

Published Date: 8 February 2017

Kelussia odoratissima Mozaff. activates intrinsic pathway of apoptosis in breast cancer cells associated with S phase cell cycle arrest via involvement of p21/p27 in vitro and in vivo

Karimian H, Arya A, Fadaeinasab M, Razavi M, Hajrezaei M, Karim Khan A, Mohd Ali H, Abdulla MA, Noordin MI

Drug Design, Development and Therapy 2017, 11:337-350

Published Date: 1 February 2017

Drug delivery in overcoming the blood–brain barrier: role of nasal mucosal grafting

Marianecci C, Rinaldi F, Hanieh PN, Di Marzio L, Paolino D, Carafa M

Drug Design, Development and Therapy 2017, 11:325-335

Published Date: 27 January 2017

Phloretin exerts hypoglycemic effect in streptozotocin-induced diabetic rats and improves insulin resistance in vitro

Shen X, Zhou N, Mi L, Hu Z, Wang L, Liu X, Zhang S

Drug Design, Development and Therapy 2017, 11:313-324

Published Date: 7 February 2017

Obinutuzumab in chronic lymphocytic leukemia: design, development and place in therapy

Al-Sawaf O, Fischer K, Engelke A, Pflug N, Hallek M, Goede V

Drug Design, Development and Therapy 2017, 11:295-304

Published Date: 25 January 2017

Theophylline action on primary human bronchial epithelial cells under proinflammatory stimuli and steroidal drugs: a therapeutic rationale approach

Gallelli L, Falcone D, Cannataro R, Perri M, Serra R, Pelaia G, Maselli R, Savino R, Spaziano G, D’Agostino B

Drug Design, Development and Therapy 2017, 11:265-272

Published Date: 23 January 2017

Plitidepsin: design, development, and potential place in therapy

Alonso-Álvarez S, Pardal E, Sánchez-Nieto D, Navarro M, Caballero MD, Mateos MV, Martín A

Drug Design, Development and Therapy 2017, 11:253-264

Published Date: 19 January 2017

Effect of roll compaction on granule size distribution of microcrystalline cellulose–mannitol mixtures: computational intelligence modeling and parametric analysis

Kazemi P, Khalid MH, Pérez Gago A, Kleinebudde P, Jachowicz R, Szlęk J, Mendyk A

Drug Design, Development and Therapy 2017, 11:241-251

Published Date: 18 January 2017

N-(3-hydroxymethyl-β-carboline-1-yl-ethyl-2-yl)-L-Phe: development toward a nanoscaled antitumor drug capable of treating complicated thrombosis and inflammation

Wu JH, Zhao M, Wang YJ, Wang YN, Zhu HM, Zhao SR, Gui L, Zhang XY, Peng SQ

Drug Design, Development and Therapy 2017, 11:225-239

Published Date: 17 January 2017

Spotlight on mavrilimumab for the treatment of rheumatoid arthritis: evidence to date

Crotti C, Raimondo MG, Becciolini A, Biggioggero M, Favalli EG

Drug Design, Development and Therapy 2017, 11:211-223

Published Date: 13 January 2017

Comparison of the long-term efficacy and safety of generic Tacrobell with original tacrolimus (Prograf) in kidney transplant recipients

Son SY, Jang HR, Lee JE, Yoo H, Kim K, Park JB, Kim SJ, Oh HY, Huh W

Drug Design, Development and Therapy 2017, 11:203-210

Published Date: 12 January 2017

Computational intelligence models to predict porosity of tablets using minimum features

Khalid MH, Kazemi P, Perez-Gandarillas L, Michrafy A, Szlęk J, Jachowicz R, Mendyk A

Drug Design, Development and Therapy 2017, 11:193-202

Published Date: 12 January 2017

Evaluation of a 2-aminoimidazole variant as adjuvant treatment for dermal bacterial infections

Draughn GL, Allen CL, Routh PA, Stone MR, Kirker KR, Boegli L, Schuchman RM, Linder KE, Baynes RE, James G, Melander C, Pollard A, Cavanagh J

Drug Design, Development and Therapy 2017, 11:153-162

Published Date: 11 January 2017

Pharmacokinetic and pharmacodynamic evaluation according to absorption differences in three formulations of ibuprofen

Shin D, Lee SJ, Ha Y, Choi YS, Kim JW, Park SR, Park MK

Drug Design, Development and Therapy 2017, 11:135-141

Published Date: 4 January 2017

A triazole derivative elicits autophagic clearance of polyglutamine aggregation in neuronal cells [Corrigendum]

Hsieh CH, Lee LC, Leong WY, Yang TC, Yao CF, Fang K

Drug Design, Development and Therapy 2017, 11:133-134

Published Date: 28 December 2016

Effects of multiple-dose ponesimod, a selective S1P1 receptor modulator, on lymphocyte subsets in healthy humans

Jurcevic S, Juif PE, Hamid C, Greenlaw R, D'Ambrosio D, Dingemanse J

Drug Design, Development and Therapy 2017, 11:123-131

Published Date: 28 December 2016

Anticancer and anti-inflammatory activities of girinimbine isolated from Murraya koenigii

Iman V, Mohan S, Abdelwahab SI, Karimian H, Nordin N, Fadaeinasab M, Noordin MI, Noor SM

Drug Design, Development and Therapy 2017, 11:103-121

Published Date: 28 December 2016

Vitamin D deficiency and the risk of tuberculosis: a meta-analysis

Huang SJ, Wang XH, Liu ZD, Cao WL, Han Y, Ma AG, Xu SF

Drug Design, Development and Therapy 2017, 11:91-102

Published Date: 28 December 2016

Analysis of pramipexole dose–response relationships in Parkinson's disease

Wang Y, Sun SG, Zhu SQ, Liu CF, Liu YM, Di Q, Shang HF, Ren Y, Xiang W, Chen SD

Drug Design, Development and Therapy 2017, 11:83-89

Published Date: 23 December 2016

Development of a chitosan based double layer-coated tablet as a platform for colon-specific drug delivery

Kim MS, Yeom DW, Kim SR, Yoon HY, Kim CH, Son HY, Kim JH, Lee S, Choi YW

Drug Design, Development and Therapy 2017, 11:45-57

Published Date: 21 December 2016

Spotlight on the 9-valent HPV vaccine

Lopalco PL

Drug Design, Development and Therapy 2017, 11:35-44

Published Date: 20 December 2016

Gastroretentive behavior of orally administered radiolabeled tamarind seed formulations in rabbits validated by gamma scintigraphy

Razavi M, Karimian H, Yeong CH, Fadaeinasab M, Khaing SL, Chung LY, Mohamad Haron DE, Noordin MI

Drug Design, Development and Therapy 2017, 11:1-15

Published Date: 19 December 2016

Folic acid-conjugated amphiphilic alternating copolymer as a new active tumor targeting drug delivery platform

Li X, Szewczuk MR, Malardier-Jugroot C

Drug Design, Development and Therapy 2016, 10:4101-4110

Published Date: 15 December 2016

Structure-based virtual screening and characterization of a novel IL-6 antagonistic compound from synthetic compound database

Wang J, Qiao C, Xiao H, Lin Z, Li Y, Zhang J, Shen B, Fu T, Feng J

Drug Design, Development and Therapy 2016, 10:4091-4100

Published Date: 15 December 2016

Protective effects of vitamin C and vitamin E against hysterosalpingography-induced epithelial degeneration and proliferation in rat endometrium

Pala Ş, Atilgan R, Kuloğlu T, Kara M, Başpınar M, Can B, Artaş G

Drug Design, Development and Therapy 2016, 10:4079-4089

Published Date: 15 December 2016

Design and in vitro/in vivo evaluation of sustained-release floating tablets of itopride hydrochloride

Ahmed SM, Ahmed Ali A, Ali AMA, Hassan OA

Drug Design, Development and Therapy 2016, 10:4061-4071

Published Date: 14 December 2016

Comparison of oral absorption models for pregabalin: usefulness of transit compartment model

Hong T, Han S, Lee J, Jeon S, Yim DS

Drug Design, Development and Therapy 2016, 10:3995-4003

Published Date: 7 December 2016

Impact of prostaglandin glaucoma drops on platelet-activating factor action: an in vitro study

Moschos MM, Nitoda E, Chatziralli IP, Panos GD, Demopoulos CA

Drug Design, Development and Therapy 2016, 10:3977-3981

Published Date: 7 December 2016

Paracetamol sharpens reflection and spatial memory: a double-blind randomized controlled study in healthy volunteers

Pickering G, Macian N, Dubray C, Pereira B

Drug Design, Development and Therapy 2016, 10:3969-3976

Published Date: 5 December 2016

Dose-dependent effects of cisplatin on the severity of testicular injury in Sprague Dawley rats: reactive oxygen species and endoplasmic reticulum stress

Soni KK, Kim HK, Choi BR, Karna KK, You JH, Cha JS, Shin YS, Lee SW, Kim CY, Park JK

Drug Design, Development and Therapy 2016, 10:3959-3968

Published Date: 12 December 2016

Increased therapeutic efficacy of a newly synthesized tyrosinase inhibitor by solid lipid nanoparticles in the topical treatment of hyperpigmentation

Al-Amin M, Cao J, Naeem M, Banna H, Kim M, Jung Y, Chung HY, Moon HR, Yoo J

Drug Design, Development and Therapy 2016, 10:3947-3957

Published Date: 2 December 2016

Loading cisplatin onto 6-mercaptopurine covalently modified MSNS: a nanomedicine strategy to improve the outcome of cisplatin therapy

Lv X, Zhao M, Wang Y, Hu X, Wu J, Jiang X, Li S, Cui C, Peng S

Drug Design, Development and Therapy 2016, 10:3933-3946

Published Date: 1 December 2016

Effect of peritoneal dialysis fluid containing osmo-metabolic agents on human endothelial cells

Bonomini M, Di Silvestre S, Di Tomo P, Di Pietro N, Mandatori D, Di Liberato L, Sirolli V, Chiarelli F, Indiveri C, Pandolfi A, Arduini A

Drug Design, Development and Therapy 2016, 10:3925-3932

Published Date: 28 November 2016

Statistical modeling methods to analyze the impacts of multiunit process variability on critical quality attributes of Chinese herbal medicine tablets

Sun F, Xu B, Zhang Y, Dai SY, Yang C, Cui XL, Shi XY, Qiao YJ

Drug Design, Development and Therapy 2016, 10:3909-3924

Published Date: 28 November 2016

Non-imidazole-based histamine H3 receptor antagonists with anticonvulsant activity in different seizure models in male adult rats

Sadek B, Saad A, Latacz G, Kuder K, Olejarz A, Karcz T, Stark H, Kieć-Kononowicz K

Drug Design, Development and Therapy 2016, 10:3879-3898

Published Date: 25 November 2016

Design, synthesis and evaluation of VEGF-siRNA/CRS as a novel vector for gene delivery

Zhao W, Zhang YF, Jiang XY, Cui CY

Drug Design, Development and Therapy 2016, 10:3851-3865

Published Date: 24 November 2016

Smart nanocrystals of artemether: fabrication, characterization, and comparative in vitro and in vivo antimalarial evaluation

Shah SMH, Ullah F, Khan S, Shah SMM, Matas MD, Hussain Z, Minhas MU, AbdEl-Salam NM, Assi KH, Isreb M

Drug Design, Development and Therapy 2016, 10:3837-3850

Published Date: 24 November 2016

Feasibility of sequential adjuvant chemotherapy with a 3-month oxaliplatin-based regimen followed by 3 months of capecitabine in patients with stage III and high-risk stage II colorectal cancer: JSWOG-C2 study

Tsuruta A, Yamashita K, Tanioka H, Tsuji A, Inukai M, Yamakawa T, Yamatsuji T, Yoshimitsu M, Toyota K, Yamano T, Nagasaka T, Okajima M

Drug Design, Development and Therapy 2016, 10:3827-3835

Published Date: 23 November 2016

Fabrication of anti-vitiligo ointment containing Psoralea corylifolia: in vitro and in vivo characterization

Hussain I, Hussain N, Manan A, Rashid A, Khan B, Bukhsh S

Drug Design, Development and Therapy 2016, 10:3805-3816

Published Date: 22 November 2016

CARD9 as a potential target in cardiovascular disease

Peterson MR, Haller SE, Ren J, Nair S, He G

Drug Design, Development and Therapy 2016, 10:3799-3804

Published Date: 22 November 2016

Comparison of bile salt/phosphatidylcholine mixed micelles in solubilization to sterols and stability

Guo Q, Cai J, Li PY, Xu DL, Ni XM, Wen H, Liu D, Lin SZ, Hu HY

Drug Design, Development and Therapy 2016, 10:3789-3798

Published Date: 17 November 2016

Increased localized delivery of piroxicam by cationic nanoparticles after intra-articular injection

Kim SR, Ho MJ, Kim SH, Cho HR, Kim HS, Choi YS, Choi YW, Kang MJ

Drug Design, Development and Therapy 2016, 10:3779-3787

Published Date: 16 November 2016

Dietary arginine silicate inositol complex inhibits periodontal tissue loss in rats with ligature-induced periodontitis

Dundar S, Eltas A, Hakki SS, Malkoc S, Uslu MO, Tuzcu M, Komorowski J, Ozercan IH, Akdemir F, Sahin K

Drug Design, Development and Therapy 2016, 10:3771-3778

Published Date: 15 November 2016

Pharmacokinetics, pharmacodynamics and safety of CKD-519, a CETP inhibitor, in healthy subjects

Kim CO, Oh ES, Choi CG, Kim YJ, Lee S, Kim S, Park MS

Drug Design, Development and Therapy 2016, 10:3763-3770

Published Date: 15 November 2016

Oncolytic adenovirus expressing interleukin-18 improves antitumor activity of dacarbazine for malignant melanoma

Yang C, Cao H, Liu N, Xu K, Ding M, Mao LJ

Drug Design, Development and Therapy 2016, 10:3755-3761

Published Date: 15 November 2016

Lentivirus-mediated knockdown of NLK inhibits small-cell lung cancer growth and metastasis

Lv MT, Li YM, Tian X, Dai SD, Sun J, Jin GJ, Jiang SY

Drug Design, Development and Therapy 2016, 10:3737-3746

Published Date: 15 November 2016

Systematic review and meta-analysis of randomized controlled trials on Wenxin keli

Wang XY, Wang Y, Feng XY, Lu Y, Zhang Y, Wang WW, Zhu WT

Drug Design, Development and Therapy 2016, 10:3725-3736

Published Date: 14 November 2016

Low-dose modified-release prednisone in axial spondyloarthritis: 3-month efficacy and tolerability

Bandinelli F, Scazzariello F, Pimenta da Fonseca E, Barreto Santiago M, Marcassa C, Nacci F, Matucci Cerinic M

Drug Design, Development and Therapy 2016, 10:3717-3724

Published Date: 14 November 2016

Effects of resveratrol on P-glycoprotein and cytochrome P450 3A in vitro and on pharmacokinetics of oral saquinavir in rats

Li JP, Liu Y, Zhang JR, Yu XT, Wang XL, Zhao LB

Drug Design, Development and Therapy 2016, 10:3699-3706

Published Date: 15 November 2016

Study of the antibacterial and antifungal activities of synthetic benzyl bromides, ketones, and corresponding chalcone derivatives

Shakhatreh MA, Al-Smadi ML, Khabour OF, Shuaibu FA, Hussein EI, Alzoubi KH

Drug Design, Development and Therapy 2016, 10:3653-3660

Published Date: 8 November 2016

Anticonvulsant effects of isomeric nonimidazole histamine H3 receptor antagonists

Sadek B, Saad A, Schwed JS, Weizel L, Walter M, Stark H

Drug Design, Development and Therapy 2016, 10:3633-3651

Published Date: 7 November 2016

Mechanism and pharmacological rescue of berberine-induced hERG channel deficiency [Corrigendum]

Yan M, Zhang KP, Shi YH, Feng LF, Lv L, Li BX

Drug Design, Development and Therapy 2016, 10:3573-3574

Published Date: 1 November 2016

Evaluating the cytotoxic effects of the water extracts of four anticancer herbs against human malignant melanoma cells

Ling BB, Michel D, Sakharkar MK, Yang J

Drug Design, Development and Therapy 2016, 10:3563-3572

Published Date: 1 November 2016

Effects of renal function on pharmacokinetics and pharmacodynamics of lesinurad in adult volunteers

Gillen M, Valdez S, Zhou D, Kerr B, Lee CA, Shen Z

Drug Design, Development and Therapy 2016, 10:3555-3562

Published Date: 1 November 2016

Mimetics of brain-derived neurotrophic factor loops 1 and 4 are active in a model of ischemic stroke in rats

Gudasheva TA, Povarnina P, Logvinov IO, Antipova TA, Seredenin SB

Drug Design, Development and Therapy 2016, 10:3545-3553

Published Date: 2 November 2016

Synthesis, anti-inflammatory, analgesic, COX1/2-inhibitory activity, and molecular docking studies of hybrid pyrazole analogues

Alam MJ, Alam O, Khan SA, Naim MJ, Islamuddin M, Deora GS

Drug Design, Development and Therapy 2016, 10:3529-3543

Published Date: 31 October 2016

Supratherapeutic dose evaluation and effect of lesinurad on cardiac repolarization: a thorough QT/QTc study

Shen Z, Gillen M, Tieu K, Nguyen M, Harmon E, Wilson DM, Kerr B, Lee CA

Drug Design, Development and Therapy 2016, 10:3509-3517

Published Date: 27 October 2016

Cardioprotective activity of placental growth factor combined with oral supplementation of L-arginine in a rat model of acute myocardial infarction

Luo L, Chen B, Huang Y, Liang Z, Li S, Yin Y, Chen J, Wu W

Drug Design, Development and Therapy 2016, 10:3483-3492

Published Date: 28 October 2016

Clinical utility of lanreotide Autogel® in gastroenteropancreatic neuroendocrine tumors

Paragliola RM, Prete A, Papi G, Torino F, Corsello A, Pontecorvi A, Corsello SM

Drug Design, Development and Therapy 2016, 10:3459-3470

Published Date: 25 October 2016

α-Aminoadipic acid protects against retinal disruption through attenuating Müller cell gliosis in a rat model of acute ocular hypertension

Wang X, Su J, Ding J, Han S, Ma W, Luo H, Hughes G, Meng Z, Yin Y, Wang Y, Li J

Drug Design, Development and Therapy 2016, 10:3449-3457

Published Date: 20 October 2016

Diminazene aceturate: an antibacterial agent for Shiga-toxin-producing Escherichia coli O157:H7

Wu SY, Park GY, Kim SH, Hulme J, An SSA

Drug Design, Development and Therapy 2016, 10:3363-3378

Published Date: 14 October 2016

Development of a microparticle-based dry powder inhalation formulation of ciprofloxacin hydrochloride applying the quality by design approach

Karimi K, Pallagi E, Szabó-Révész P, Csóka I, Ambrus R

Drug Design, Development and Therapy 2016, 10:3331-3343

Published Date: 12 October 2016

The expression of HoxB5 and SPC in neonatal rat lung at exposure to fluoxetine

Taghizadeh R, Taghipour Z, Karimi A, Shamsizadeh A, Taghavi MM, Shariati M, Shabanizadeh A, Jafari Naveh HR, Bidaki R, Aminzadeh F

Drug Design, Development and Therapy 2016, 10:3323-3329

Published Date: 2 November 2016

Moringin activates Wnt canonical pathway by inhibiting GSK3β in a mouse model of experimental autoimmune encephalomyelitis

Giacoppo S, Soundara Rajan T, De Nicola GR, Iori R, Bramanti P, Mazzon E

Drug Design, Development and Therapy 2016, 10:3291-3304

Published Date: 4 October 2016

Stability of apomorphine in solutions containing selected antioxidant agents

Ang ZY, Boddy M, Liu Y, Sunderland B

Drug Design, Development and Therapy 2016, 10:3253-3265

Published Date: 3 October 2016

Homology modeling, molecular dynamics, and virtual screening of NorA efflux pump inhibitors of Staphylococcus aureus

Bhaskar BV, Babu TMC, Reddy NV, Rajendra W

Drug Design, Development and Therapy 2016, 10:3237-3252

Published Date: 3 October 2016

Druggability analysis and classification of protein tyrosine phosphatase active sites

Ghattas MA, Raslan N, Sadeq A, Al Sorkhy M, Atatreh N

Drug Design, Development and Therapy 2016, 10:3197-3209

Published Date: 30 September 2016

Looking for inhibitors of the dengue virus NS5 RNA-dependent RNA-polymerase using a molecular docking approach

Galiano V, Garcia-Valtanen P, Micol V, Encinar JA

Drug Design, Development and Therapy 2016, 10:3163-3181

Published Date: 11 October 2016

Incidence and risk of hepatic toxicities with PD-1 inhibitors in cancer patients: a meta-analysis

Zhang X, Ran Y, Wang K, Zhu Y, Li J

Drug Design, Development and Therapy 2016, 10:3153-3161

Published Date: 28 September 2016

Resolvins and aliamides: lipid autacoids in ophthalmology – what promise do they hold?

Hesselink JMK, Chiosi F, Costagliola C

Drug Design, Development and Therapy 2016, 10:3133-3141

Published Date: 27 September 2016

Pharmacokinetics, absorption, and excretion of radiolabeled revexepride: a Phase I clinical trial using a microtracer and accelerator mass spectrometry-based approach

Flach S, Croft M, Ding J, Budhram R, Pankratz T, Pennick M, Scarfe G, Troy S, Getsy J

Drug Design, Development and Therapy 2016, 10:3125-3132

Published Date: 27 September 2016

Structural insights into the polypharmacological activity of quercetin on serine/threonine kinases

Baby B, Antony P, Al Halabi W, Al Homedi Z, Vijayan R

Drug Design, Development and Therapy 2016, 10:3109-3123

Published Date: 27 September 2016

Spotlight on sirukumab for the treatment of rheumatoid arthritis: the evidence to date

Lazzerini PE, Capecchi PL, Guidelli GM, Selvi E, Acampa M, Laghi-Pasini F

Drug Design, Development and Therapy 2016, 10:3083-3098

Published Date: 26 September 2016

Formononetin, an active compound of Astragalus membranaceus (Fisch) Bunge, inhibits hypoxia-induced retinal neovascularization via the HIF-1α/VEGF signaling pathway

Wu J, Ke X, Ma N, Wang W, Fu W, Zhang H, Zhao M, Gao X, Hao X, Zhang Z

Drug Design, Development and Therapy 2016, 10:3071-3081

Published Date: 23 September 2016

Efficacy of an acquainted drug in the treatment of inflammatory low back pain: sulfasalazine under investigation

Moghimi J, Rezaei AA, Ghorbani R, Razavi MR, Pahlevan D

Drug Design, Development and Therapy 2016, 10:3065-3069

Published Date: 23 September 2016

TopBP1 contributes to the chemoresistance in non-small cell lung cancer through upregulation of p53

Lv Y, Huo Y, Yu X, Liu R, Zhang S, Zheng X, Zhang X

Drug Design, Development and Therapy 2016, 10:3053-3064

Published Date: 23 September 2016

Controlled release of TGF-beta 1 from RADA self-assembling peptide hydrogel scaffolds

Zhou A, Chen S, He B, Zhao W, Chen X, Jiang D

Drug Design, Development and Therapy 2016, 10:3043-3051

Published Date: 22 September 2016

Effect of low dose of intrathecal pethidine on the incidence and intensity of shivering during cesarean section under spinal anesthesia: a randomized, placebo-controlled, double-blind clinical trial

Shami S, Nasseri K, Shirmohammadi M, Sarshivi F, Ghadami N, Ghaderi E, Pouladi M, Barzanji A

Drug Design, Development and Therapy 2016, 10:3005-3012

Published Date: 20 September 2016

Profile of adalimumab and its potential in the treatment of uveitis

Balevic SJ, Rabinovich CE

Drug Design, Development and Therapy 2016, 10:2997-3003

Published Date: 19 September 2016

Radiolabeled tirofiban – a potential radiopharmaceutical for detection of deep venous thrombosis

Darkovska-Serafimovska M, Janevik-Ivanovska E, Djorgoski I, Arsova-Sarafinovska Z, Zdravkovska M, Balkanov T, Ugresic N

Drug Design, Development and Therapy 2016, 10:2989-2996

Published Date: 21 September 2016

Combined computational and experimental studies of molecular interactions of albuterol sulfate with bovine serum albumin for pulmonary drug nanoparticles

Lin SH, Cui W, Wang GL, Meng S, Liu YC, Jin HW, Zhang LR, Xie Y

Drug Design, Development and Therapy 2016, 10:2973-2987

Published Date: 15 September 2016

Application of physiologically based pharmacokinetic modeling in predicting drug–drug interactions for sarpogrelate hydrochloride in humans

Min JS, Kim D, Park JB, Heo H, Bae SH, Seo JH, Oh E, Bae SK

Drug Design, Development and Therapy 2016, 10:2959-2972

Published Date: 14 September 2016

A triazole derivative elicits autophagic clearance of polyglutamine aggregation in neuronal cells

Hsieh CH, Lee LC, Leong WY, Yang TC, Yao CF, Fang K

Drug Design, Development and Therapy 2016, 10:2947-2957

Published Date: 14 September 2016

Effects of low-carbohydrate diet therapy in overweight subject with autoimmune thyroiditis: possible synergism with ChREBP

Esposito T, Lobaccaro JM, Esposito MG, Monda V, Messina A, Paolisso G, Varriale B, Monda M, Messina G

Drug Design, Development and Therapy 2016, 10:2939-2946

Published Date: 14 September 2016

Protein kinase C–mediated sodium glucose transporter 1 activation in precondition-induced cardioprotection

Kanwal A, Kasetti S, Putcha UK, Asthana S, Banerjee SK

Drug Design, Development and Therapy 2016, 10:2929-2938

Published Date: 14 September 2016

Effects of an immunosuppressive treatment on the rat prostate

Grabowska M, Kędzierska K, Michałek K, Słuczanowska-Głąbowska S, Grabowski M, Piasecka M, Kram A, Rotter I, Rył A, Laszczyńska M

Drug Design, Development and Therapy 2016, 10:2899-2915

Published Date: 12 September 2016

Understanding cytoskeleton regulators in glioblastoma multiforme for therapy design

Masoumi S, Harisankar A, Gracias A, Bachinger F, Fufa T, Chandrasekar G, Gaunitz F, Walfridsson J, Kitambi SS

Drug Design, Development and Therapy 2016, 10:2881-2897

Published Date: 12 September 2016

Synthesis, solubility, plasma stability, and pharmacological evaluation of novel sulfonylhydrazones designed as anti-diabetic agents

Zapata-Sudo G, da Costa Nunes IK, Araujo JSC, da Silva JS, Trachez MM, da Silva TF, da Costa FP, Sudo RT, Barreiro EJ, Lima LM

Drug Design, Development and Therapy 2016, 10:2869-2879

Published Date: 9 September 2016

In situ delivery of thermosensitive gel-mediated 5-fluorouracil microemulsion for the treatment of colorectal cancer

Wang LL, Huang S, Guo HH, Han YX, Zheng WS, Jiang JD

Drug Design, Development and Therapy 2016, 10:2855-2867

Published Date: 8 September 2016

Downregulation of DOCK1 sensitizes bladder cancer cells to cisplatin through preventing epithelial–mesenchymal transition

Chen D, Chen W, Jiang H, Yang H, Wang Y, Chen J

Drug Design, Development and Therapy 2016, 10:2845-2853

Published Date: 8 September 2016

Eltrombopag for the treatment of aplastic anemia: current perspectives

Lum SH, Grainger JD

Drug Design, Development and Therapy 2016, 10:2833-2843

Published Date: 13 September 2016

Development and in vitro characterization of poly(lactide-co-glycolide) microspheres loaded with an antibacterial natural drug for the treatment of long-term bacterial infections

Reinbold J, Hierlemann T, Hinkel H, Müller I, Maier ME, Weindl T, Schlensak C, Wendel HP, Krajewski S,

Drug Design, Development and Therapy 2016, 10:2823-2832

Published Date: 7 September 2016

Intranasal administration of elastin-like polypeptide for therapeutic delivery to the central nervous system

McGowan JWD, Shao Q, Vig PJS, Bidwell III GL

Drug Design, Development and Therapy 2016, 10:2803-2813

Published Date: 6 September 2016

The use of misoprostol for cervical priming prior to hysteroscopy: a systematic review and analysis

Hua Y, Zhang W, Hu X, Yang A, Zhu X

Drug Design, Development and Therapy 2016, 10:2789-2801

Published Date: 6 September 2016

Two Phase II randomized trials on the CRTh2 antagonist AZD1981 in adults with asthma

Kuna P, Bjermer L, Tornling G

Drug Design, Development and Therapy 2016, 10:2759-2770

Published Date: 31 August 2016

Anti-inflammatory drugs for Duchenne muscular dystrophy: focus on skeletal muscle-releasing factors

Miyatake S, Shimizu-Motohashi Y, Takeda S, Aoki Y

Drug Design, Development and Therapy 2016, 10:2745-2758

Published Date: 30 August 2016

Chloroquine improves left ventricle diastolic function in streptozotocin-induced diabetic mice

Yuan X, Xiao YC, Zhang GP, Hou N, Wu XQ, Chen WL, Luo JD, Zhang GS

Drug Design, Development and Therapy 2016, 10:2729-2737

Published Date: 30 August 2016

Clinical study in genital herpes: natural Gene-Eden-VIR/Novirin versus acyclovir, valacyclovir, and famciclovir

Polansky H, Javaherian A, Itzkovitz E

Drug Design, Development and Therapy 2016, 10:2713-2722

Published Date: 29 August 2016

Nanomedical strategy to prolong survival period, heighten cure rate, and lower systemic toxicity of S180 mice treated with MTX/MIT

Song N, Zhao M, Wang Y, Hu X, Wu J, Jiang X, Li S, Cui C, Peng S

Drug Design, Development and Therapy 2016, 10:2701-2711

Published Date: 30 August 2016

Ticagrelor promotes atherosclerotic plaque stability in a mouse model of advanced atherosclerosis

Preusch MR, Rusnak J, Staudacher K, Mogler C, Uhlmann L, Sievers P, Bea F, Katus HA, Blessing E, Staudacher I

Drug Design, Development and Therapy 2016, 10:2691-2699

Published Date: 26 August 2016

Design, synthesis, and characterization of (1-(4-aryl)-1H-1,2,3-triazol-4-yl)methyl, substituted phenyl-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylates against Mycobacterium tuberculosis

Venugopala KN, Dharma Rao GB, Bhandary S, Pillay M, Chopra D, Aldhubiab BE, Attimarad M, Alwassil OI, Harsha S, Mlisana K

Drug Design, Development and Therapy 2016, 10:2681-2690

Published Date: 25 August 2016

Development of betulinic acid as an agonist of TGR5 receptor using a new in vitro assay

Lo SH, Cheng KC, Li YX, Chang CH, Cheng JT, Lee KS

Drug Design, Development and Therapy 2016, 10:2669-2676

Published Date: 22 August 2016

Effects of alprostadil and iloprost on renal, lung, and skeletal muscle injury following hindlimb ischemia–reperfusion injury in rats

Erer D, Özer A, Demirtaş H, Gönül İI, Kara H, Arpacı H, Çomu FM, Oktar GL, Arslan M, Küçük A

Drug Design, Development and Therapy 2016, 10:2651-2658

Published Date: 19 August 2016

Pharmacokinetic profile of defibrotide in patients with renal impairment

Tocchetti P, Tudone E, Marier JF, Marbury TC, Zomorodi K, Eller M

Drug Design, Development and Therapy 2016, 10:2631-2641

Published Date: 16 August 2016

Novel glyoxalase-I inhibitors possessing a “zinc-binding feature” as potential anticancer agents

Al-Balas QA, Hassan MA, Al-Shar’i NA, Mhaidat NM, Almaaytah AM, Al-Mahasneh FM, Isawi IH

Drug Design, Development and Therapy 2016, 10:2623-2629

Published Date: 17 August 2016

Construction of p66Shc gene interfering lentivirus vectors and its affections on alveolar epithelial cells apoptosis induced by hyperoxia

Zhang C, Dong WB, Zhao S, Li QP, Kang L, Lei XP, Guo L, Zhai XS

Drug Design, Development and Therapy 2016, 10:2611-2622

Published Date: 16 August 2016

Design and characteristics of cytotoxic fibroblast growth factor 1 conjugate for fibroblast growth factor receptor-targeted cancer therapy

Szlachcic A, Zakrzewska M, Lobocki M, Jakimowicz P, Otlewski J

Drug Design, Development and Therapy 2016, 10:2547-2560

Published Date: 9 August 2016

Effects of salvianolate on bone metabolism in glucocorticoid-treated lupus-prone B6.MRL-Faslpr/J mice

Liu Y, Cui Y, Zhang X, Gao X, Su Y, Xu B, Wu T, Chen W, Cui L

Drug Design, Development and Therapy 2016, 10:2535-2546

Published Date: 9 August 2016

Pharmacokinetic and pharmacodynamic interactions between metformin and a novel dipeptidyl peptidase-4 inhibitor, evogliptin, in healthy subjects

Rhee SJ, Choi Y, Lee S, Oh J, Kim SJ, Yoon SH, Cho JY, Yu KS

Drug Design, Development and Therapy 2016, 10:2525-2534

Published Date: 10 August 2016

NAD(P)H:quinone oxidoreductase 1 inducer activity of some novel anilinoquinazoline derivatives

Ghorab MM, Alsaid MS, Higgins M, Dinkova-Kostova AT, Shahat AA, Elghazawy NH, Arafa RK

Drug Design, Development and Therapy 2016, 10:2515-2524

Published Date: 8 August 2016

Endoplasmic reticulum stress-induced autophagy determines the susceptibility of melanoma cells to dabrafenib

Ji C, Zhang ZP, Chen LH, Zhou KL, Li DJ, Wang P, Huang SY, Gong T, Cheng B

Drug Design, Development and Therapy 2016, 10:2491-2498

Published Date: 4 August 2016

Metformin increases pressure pain threshold in lean women with polycystic ovary syndrome

Kiałka M, Milewicz T, Sztefko K, Rogatko I, Majewska R

Drug Design, Development and Therapy 2016, 10:2483-2490

Published Date: 3 August 2016

Effects of lornoxicam and intravenous ibuprofen on erythrocyte deformability and hepatic and renal blood flow in rats

Arpacı H, Çomu FM, Küçük A, Kösem B, Kartal S, Şıvgın V, Turgut HC, Aydın ME, Koç DS, Arslan M

Drug Design, Development and Therapy 2016, 10:2477-2481

Published Date: 3 August 2016

Design of a nanostructured lipid carrier intended to improve the treatment of tuberculosis

Pinheiro M, Ribeiro R, Vieira A, Andrade F, Reis S

Drug Design, Development and Therapy 2016, 10:2467-2475

Published Date: 2 August 2016

Receptor tyrosine kinase (c-Kit) inhibitors: a potential therapeutic target in cancer cells

Abbaspour Babaei M, Kamalidehghan B, Saleem M, Huri HZ, Ahmadipour F

Drug Design, Development and Therapy 2016, 10:2443-2459

Published Date: 1 August 2016

The role of CD147 expression in prostate cancer: a systematic review and meta-analysis

Ye Y, Li SL, Wang Y, Yao Y, Wang J, Ma YY, Hao XK

Drug Design, Development and Therapy 2016, 10:2435-2442

Published Date: 1 August 2016

Flurbiprofen–antioxidant mutual prodrugs as safer nonsteroidal anti-inflammatory drugs: synthesis, pharmacological investigation, and computational molecular modeling

Ashraf Z, Alamgeer, Kanwal M, Hassan M, Abdullah S, Waheed M, Ahsan H, Kim SJ

Drug Design, Development and Therapy 2016, 10:2401-2419

Published Date: 27 July 2016

A review of omalizumab for the management of severe asthma

Lin CH, Cheng SL

Drug Design, Development and Therapy 2016, 10:2369-2378

Published Date: 26 July 2016

Distinct role of the Fas rs1800682 and FasL rs763110 polymorphisms in determining the risk of breast cancer among Han Chinese women

Wang M, Wang Z, Wang XJ, Jin TB, Dai ZM, Kang HF, Guan HT, Ma XB, Liu XH, Dai ZJ

Drug Design, Development and Therapy 2016, 10:2359-2367

Published Date: 25 July 2016

Paclitaxel plus valproic acid versus paclitaxel alone as second- or third-line therapy for advanced gastric cancer: a randomized Phase II trial

Fushida S, Kinoshita J, Kaji M, Oyama K, Hirono Y, Tsukada T, Fujimura T, Ohta T

Drug Design, Development and Therapy 2016, 10:2353-2358

Published Date: 25 July 2016

Novel A20-gene-eluting stent inhibits carotid artery restenosis in a porcine model

Zhou ZH, Peng J, Meng ZY, Chen L, Huang JL, Huang HQ, Li L, Zeng W, Wei Y, Zhu CH, Chen KN

Drug Design, Development and Therapy 2016, 10:2341-2351

Published Date: 8 August 2016

Voiding dysfunction in patients with nasal congestion treated with pseudoephedrine: a prospective study

Shao IH, Wu CC, Tseng HJ, Lee TJ, Lin YH, Tam YY

Drug Design, Development and Therapy 2016, 10:2333-2339

Published Date: 19 July 2016

Prediction of selective estrogen receptor beta agonist using open data and machine learning approach

Niu AQ, Xie LJ, Wang H, Zhu B, Wang SQ

Drug Design, Development and Therapy 2016, 10:2323-2331

Published Date: 18 July 2016

SPOCK1 promotes tumor growth and metastasis in human prostate cancer

Chen Q, Yao YT, Xu H, Chen YB, Gu M, Cai ZK, Wang Z

Drug Design, Development and Therapy 2016, 10:2311-2321

Published Date: 18 July 2016

Rational design and synthesis of novel diphenyl ether derivatives as antitubercular agents

Kar SS, Bhat G V, Rao PP, Shenoy VP, Bairy I, Shenoy GG

Drug Design, Development and Therapy 2016, 10:2299-2310

Published Date: 18 July 2016

Galeterone for the treatment of advanced prostate cancer: the evidence to date

Bastos DA, Antonarakis ES

Drug Design, Development and Therapy 2016, 10:2289-2297

Published Date: 15 July 2016

The influence of intrauterine exposure to immunosuppressive treatment on changes in the immune system in juvenile Wistar rats

Kabat-Koperska J, Kolasa-Wołosiuk A, Wojciuk B, Wojciechowska-Koszko I, Roszkowska P, Krasnodębska-Szponder B, Paczkowska E, Safranow K, Gołembiewska E, Machaliński B, Ciechanowski K

Drug Design, Development and Therapy 2016, 10:2279-2288

Published Date: 14 July 2016

Simvastatin attenuates radiation-induced salivary gland dysfunction in mice

Xu L, Yang X, Chen J, Ge X, Qin Q, Zhu H, Zhang C, Sun X

Drug Design, Development and Therapy 2016, 10:2271-2278

Published Date: 13 July 2016

Thymoquinone subdues tumor growth and potentiates the chemopreventive effect of 5-fluorouracil on the early stages of colorectal carcinogenesis in rats

Kensara OA, El-Shemi AG, Mohamed AM, Refaat B, Idris S, Ahmad J

Drug Design, Development and Therapy 2016, 10:2239-2253

Published Date: 11 July 2016

Pharmacogenetic analysis of cinacalcet response in secondary hyperparathyroidism patients

Jeong S, Kim IW, Oh KH, Han N, Joo KW, Kim HJ, Oh JM

Drug Design, Development and Therapy 2016, 10:2211-2225

Published Date: 8 July 2016

Acyl lipidation of a peptide: effects on activity and epidermal permeability in vitro

Rocco D, Ross J, Murray PE, Caccetta R

Drug Design, Development and Therapy 2016, 10:2203-2209

Published Date: 8 July 2016

Rosmarinic acid ameliorates hyperglycemia and insulin sensitivity in diabetic rats, potentially by modulating the expression of PEPCK and GLUT4

Runtuwene J, Cheng KC, Asakawa A, Amitani H, Amitani M, Morinaga A, Takimoto Y, Kairupan BHR, Inui A

Drug Design, Development and Therapy 2016, 10:2193-2202

Published Date: 7 July 2016

Effect of N-methyl deuteration on metabolism and pharmacokinetics of enzalutamide

Jiang J, Pang X, Li L, Dai X, Diao X, Chen X, Zhong D, Wang Y, Chen Y

Drug Design, Development and Therapy 2016, 10:2181-2191

Published Date: 7 July 2016

The effects of ferulic acid on the pharmacokinetics of warfarin in rats after biliary drainage

Li H, Wang Y, Fan R, Lv H, Sun H, Xie H, Tang T, Luo J, Xia Z

Drug Design, Development and Therapy 2016, 10:2173-2180

Published Date: 6 July 2016

Cabozantinib in the treatment of advanced renal cell carcinoma: design, development, and potential place in the therapy

Grassi P, Verzoni E, Ratta R, Mennitto A, de Braud F, Procopio G

Drug Design, Development and Therapy 2016, 10:2167-2172

Published Date: 5 July 2016

Real-time monitoring of cisplatin cytotoxicity on three-dimensional spheroid tumor cells

Baek NH, Seo OW, Lee J, Hulme J, An SSA

Drug Design, Development and Therapy 2016, 10:2155-2165

Published Date: 4 July 2016

Pharmacophore modeling and in silico toxicity assessment of potential anticancer agents from African medicinal plants

Ntie-Kang F, Simoben CV, Karaman B, Ngwa VF, Judson PN, Sippl W, Mbaze LM

Drug Design, Development and Therapy 2016, 10:2137-2154

Published Date: 4 July 2016

Clinical implications for substandard, nonproprietary medicines in multiple sclerosis: focus on fingolimod

Correale J, Chiquete E, Boyko A, Beran RG, Strauch JB, Milojevic S, Frider N

Drug Design, Development and Therapy 2016, 10:2109-2117

Published Date: 30 June 2016

Sitagliptin attenuates cardiomyopathy by modulating the JAK/STAT signaling pathway in experimental diabetic rats

Al-Rasheed NM, Al-Rasheed NM, Hasan IH, Al-Amin MA, Al-Ajmi HN, Mahmoud AM

Drug Design, Development and Therapy 2016, 10:2095-2107

Published Date: 28 June 2016

Golimumab in radiographic and nonradiographic axial spondyloarthritis: a review of clinical trials

Toussirot E, Vauchy C, Binda D, Michel F

Drug Design, Development and Therapy 2016, 10:2087-2094

Published Date: 1 July 2016

Dietary arginine silicate inositol complex increased bone healing: histologic and histomorphometric study

Yaman F, Acikan I, Dundar S, Simsek S, Gul M, Ozercan İH, Komorowski J, Sahin K

Drug Design, Development and Therapy 2016, 10:2081-2086

Published Date: 27 June 2016

Secukinumab for rheumatology: development and its potential place in therapy

Koenders MI, van den Berg WB

Drug Design, Development and Therapy 2016, 10:2069-2080

Published Date: 24 June 2016

The cytotoxicity study of praziquantel enantiomers

Sun Q, Mao RF, Wang DL, Hu CY, Zheng Y, Sun DQ

Drug Design, Development and Therapy 2016, 10:2061-2068

Published Date: 24 June 2016

Anti-dengue drug: viral polyprotein, a potential target

Mahmood SU, Mushtaq M, Syed MJ

Drug Design, Development and Therapy 2016, 10:2047-2048

Published Date: 24 June 2016

Fondaparinux vs warfarin for the treatment of unsuspected pulmonary embolism in cancer patients

Amato B, Compagna R, Rocca A, Bianco T, Milone M, Sivero L, Vigliotti G, Amato M, Danzi M, Aprea G, Gallelli L, de Franciscis S, Serra R

Drug Design, Development and Therapy 2016, 10:2041-2046

Published Date: 23 June 2016

A novel pH–enzyme-dependent mesalamine colon-specific delivery system

Jin L, Ding Y, Zhang Y, Xu X, Cao Q

Drug Design, Development and Therapy 2016, 10:2021-2028

Published Date: 20 June 2016

MART-10, a newly synthesized vitamin D analog, represses metastatic potential of head and neck squamous carcinoma cells

Yang SW, Tsai CY, Pan YC, Yeh CN, Pang JHS, Takano M, Kittaka A, Juang HH, Chen TC, Chiang KC

Drug Design, Development and Therapy 2016, 10:1995-2002

Published Date: 17 June 2016

Double-blind, randomized, double-dummy clinical trial comparing the efficacy of ketorolac trometamol and naproxen for acute low back pain

Plapler PG, Scheinberg MA, Ecclissato CC, Bocchi de Oliveira MF, Amazonas RB

Drug Design, Development and Therapy 2016, 10:1987-1993

Published Date: 17 June 2016

Prophylactic effects of Clausena excavata Burum. f. leaf extract in ethanol-induced gastric ulcers

Albaayit SFA, Abba Y, Abdullah R, Abdullah N

Drug Design, Development and Therapy 2016, 10:1973-1986

Published Date: 15 June 2016

Efficacy and safety of gemcitabine plus erlotinib for locally advanced or metastatic pancreatic cancer: a systematic review and meta-analysis

Wang Y, Hu GF, Zhang QQ, Tang N, Guo J, Liu LY, Han X, Wang X, Wang ZH

Drug Design, Development and Therapy 2016, 10:1961-1972

Published Date: 13 June 2016

A novel imidazopyridine derivative, X22, attenuates sepsis-induced lung and liver injury by inhibiting the inflammatory response in vitro and in vivo

Ge X, Feng Z, Xu T, Wu B, Chen H, Xu F, Fu L, Shan X, Dai Y, Zhang Y, Liang G

Drug Design, Development and Therapy 2016, 10:1947-1959

Published Date: 24 June 2016

The efficacy of nebulized magnesium sulfate alone and in combination with salbutamol in acute asthma

Sarhan HA, EL-Garhy OH, Ali MA, Youssef NA

Drug Design, Development and Therapy 2016, 10:1927-1933

Published Date: 9 June 2016

In vivo gastric residence and gastroprotective effect of floating gastroretentive tablet of DA-9601, an extract of Artemisia asiatica, in beagle dogs

Kim JS, Cha KH, Kang SY, Won D, Jang SW, Son M, Son MH, Choi HJ, Lee YW, Kang MJ

Drug Design, Development and Therapy 2016, 10:1917-1925

Published Date: 9 June 2016

Role of cytochrome P450 2D6 genetic polymorphism in carvedilol hydroxylation in vitro

Wang Z, Wang L, Xu RA, Zhan YY, Huang CK, Dai DP, Cai JP, Hu GX

Drug Design, Development and Therapy 2016, 10:1909-1916

Published Date: 8 June 2016

Flavokawain derivative FLS induced G2/M arrest and apoptosis on breast cancer MCF-7 cell line

Ali NM, Akhtar MN, Ky H, Lim KL, Abu N, Zareen S, Ho WY, Alan-Ong HK, Tan SW, Alitheen NB, Ismail JB, Yeap SK, Kamarul T

Drug Design, Development and Therapy 2016, 10:1897-1907

Published Date: 10 June 2016

Molecular mechanisms of cisplatin resistance in cervical cancer

Zhu H, Luo H, Zhang W, Shen Z, Hu X, Zhu X

Drug Design, Development and Therapy 2016, 10:1885-1895

Published Date: 7 June 2016

Erythropoietin ameliorates hyperglycemia in type 1-like diabetic rats

Niu HS, Chang CH, Niu CS, Cheng JT, Lee KS

Drug Design, Development and Therapy 2016, 10:1877-1884

Published Date: 3 June 2016

Indigofera oblongifolia mitigates lead-acetate-induced kidney damage and apoptosis in a rat model

Dkhil MA, Al-Khalifa MS, Al-Quraishy S, Zrieq R, Abdel Moneim AE

Drug Design, Development and Therapy 2016, 10:1847-1856

Published Date: 2 June 2016

Nelfinavir is effective against human cervical cancer cells in vivo: a potential treatment modality in resource-limited settings

Davis MA, Delaney JR, Patel CB, Storgard R, Stupack DG

Drug Design, Development and Therapy 2016, 10:1837-1846

Published Date: 2 June 2016

Synthesis, activity, and docking study of phenylthiazole acids as potential agonists of PPARγ

Ma L, Wang T, Shi M, Ye H

Drug Design, Development and Therapy 2016, 10:1807-1815

Published Date: 30 May 2016

The arsenal of pathogens and antivirulence therapeutic strategies for disarming them

Brannon JR, Hadjifrangiskou M

Drug Design, Development and Therapy 2016, 10:1795-1806

Published Date: 27 May 2016

An open-label clinical trial of agalsidase alfa enzyme replacement therapy in children with Fabry disease who are naïve to enzyme replacement therapy

Goker-Alpan O, Longo N, McDonald M, Shankar SP, Schiffmann R, Chang P, Shen Y, Pano A

Drug Design, Development and Therapy 2016, 10:1771-1781

Published Date: 25 May 2016

Apremilast in the therapy of moderate-to-severe chronic plaque psoriasis

Gisondi P, Girolomoni G

Drug Design, Development and Therapy 2016, 10:1763-1770

Published Date: 25 May 2016

Activity of a novel sulfonamide compound 2-nitro-N-(pyridin-2-ylmethyl)benzenesulfonamide against Leishmania donovani

Dikhit MR, Purkait B, Singh R, Sahoo BR, Kumar A, Kar RK, Ansari MY, Saini S, Abhishek K, Sahoo GC, Das S, Das P

Drug Design, Development and Therapy 2016, 10:1753-1761

Published Date: 26 May 2016

Computer-aided vaccine designing approach against fish pathogens Edwardsiella tarda and Flavobacterium columnare using bioinformatics softwares

Mahendran R, Jeyabaskar S, Sitharaman G, Michael RD, Paul AV

Drug Design, Development and Therapy 2016, 10:1703-1714

Published Date: 23 May 2016

Electroporation-delivered transdermal neostigmine in rats: equivalent action to intravenous administration

Berkó S, Szűcs KF, Balázs B, Csányi E, Varju G, Sztojkov-Ivanov A, Budai-Szűcs M, Bóta J, Gáspár R

Drug Design, Development and Therapy 2016, 10:1695-1701

Published Date: 19 May 2016

Safety, tolerability, pharmacokinetics, and pharmacodynamics of novel glucokinase activator HMS5552: results from a first-in-human single ascending dose study

Xu HR, Sheng L, Chen WL, Yuan F, Yang MJ, Li H, Li XN, Choi J, Zhao GY, Hu TX, Li YG, Zhang Y, Chen L

Drug Design, Development and Therapy 2016, 10:1619-1626

Published Date: 9 May 2016

Effectiveness, durability, and safety of darunavir/ritonavir in HIV-1-infected patients in routine clinical practice in Italy: a postauthorization noninterventional study

Antinori A, Meraviglia P, d’Arminio Monforte A, Castagna A, Mussini C, Bini T, Gianotti N, Rusconi S, Colella E, Airoldi G, Mancusi D, Termini R

Drug Design, Development and Therapy 2016, 10:1589-1603

Published Date: 6 May 2016

Fimasartan for independent reduction of blood pressure variability in mild-to-moderate hypertension

Shin MS, Kang DR, Kim C, Cho EJ, Sung KC, Kang SM, Kim DS, Joo SJ, Lee SH, Hwang KK, Park JB

Drug Design, Development and Therapy 2016, 10:1573-1580

Published Date: 5 May 2016

Fungistatic activity of all-trans retinoic acid against Aspergillus fumigatus and Candida albicans

Campione E, Gaziano R, Marino D, Orlandi A

Drug Design, Development and Therapy 2016, 10:1551-1555

Published Date: 29 April 2016

Zolav®: a new antibiotic for the treatment of acne [Corrigendum]

Dinant A, Boulos RA

Drug Design, Development and Therapy 2016, 10:1549-1550

Published Date: 29 April 2016

Efficacy and safety of different doses of a slow-release corticosteroid implant for macular edema [Corrigendum]

Liu QY, He MM, Shi H, Wang QY, Du YR, Liu JL, Ren CD, Xu D, Yu J

Drug Design, Development and Therapy 2016, 10:1547-1548

Published Date: 27 April 2016

The influence of dietary sodium content on the pharmacokinetics and pharmacodynamics of fimasartan

Gu N, Cho JY, Shin KH, Jang IJ, Rhee MY

Drug Design, Development and Therapy 2016, 10:1525-1531

Published Date: 19 April 2016

Autophagy inhibition enhances RAD001-induced cytotoxicity in human bladder cancer cells

Lin JF, Lin YC, Yang SC, Tsai TF, Chen HE, Chou KY, Hwang TIS

Drug Design, Development and Therapy 2016, 10:1501-1513

Published Date: 18 April 2016

Design, synthesis, and biological evaluation of 3-vinyl-quinoxalin-2(1H)-one derivatives as novel antitumor inhibitors of FGFR1

Liu Z, Yu S, Chen D, Shen G, Wang Y, Hou L, Lin D, Zhang JS, Ye F

Drug Design, Development and Therapy 2016, 10:1489-1500

Published Date: 3 May 2016

Neuroprotective effect of β-asarone against Alzheimer’s disease: regulation of synaptic plasticity by increased expression of SYP and GluR1

Liu SJ, Yang C, Zhang Y, Su RY, Chen JL, Jiao MM, Chen HF, Zheng N, Luo S, Chen YB, Quan SJ, Wang Q

Drug Design, Development and Therapy 2016, 10:1461-1469

Published Date: 15 April 2016

Zoledronate upregulates MMP-9 and -13 in rat vascular smooth muscle cells by inducing oxidative stress

Arun MZ, Reel B, Sala-Newby GB, Bond M, Tsaousi A, Maskell P, Newby AC

Drug Design, Development and Therapy 2016, 10:1453-1460

Published Date: 18 April 2016

Xyloketal-derived small molecules show protective effect by decreasing mutant Huntingtin protein aggregates in Caenorhabditis elegans model of Huntington’s disease

Zeng YX, Guo WY, Xu GQ, Wang QM, Feng LY, Long SM, Liang FY, Huang Y, Lu XL, Li SC, Zhou JB, Burgunder JM, Pang JY, Pei Z

Drug Design, Development and Therapy 2016, 10:1443-1451

Published Date: 13 April 2016

Baicalein suppresses metastasis of breast cancer cells by inhibiting EMT via downregulation of SATB1 and Wnt/β-catenin pathway

Ma X, Yan W, Dai Z, Gao X, Ma Y, Xu Q, Jiang J, Zhang S

Drug Design, Development and Therapy 2016, 10:1419-1441

Published Date: 18 April 2016

Functionalized D-form self-assembling peptide hydrogels for bone regeneration

He B, Ou Y, Zhou A, Chen S, Zhao W, Zhao J, Li H, Zhu Y, Zhao Z, Jiang D

Drug Design, Development and Therapy 2016, 10:1379-1388

Published Date: 11 April 2016

Neuroprotective effects of salidroside through PI3K/Akt pathway activation in Alzheimer’s disease models

Zhang B, Wang Y, Li H, Xiong R, Zhao Z, Chu X, Li Q, Sun S, Chen S

Drug Design, Development and Therapy 2016, 10:1335-1343

Published Date: 6 April 2016

Identification of new drug candidates against Borrelia burgdorferi using high-throughput screening

Pothineni VR, Wagh D, Babar MM, Inayathullah M, Solow-Cordero DE, Kim KM, Samineni AV, Parekh MB, Tayebi L, Rajadas J

Drug Design, Development and Therapy 2016, 10:1307-1322

Published Date: 1 April 2016

In vitro and in vivo efficacy of afatinib as a single agent or in combination with gemcitabine for the treatment of nasopharyngeal carcinoma

Xue C, Tian Y, Zhang J, Zhao YY, Zhan JH, Fang WF, Zhang L

Drug Design, Development and Therapy 2016, 10:1299-1306

Published Date: 31 March 2016

Curcumin protects against myocardial infarction-induced cardiac fibrosis via SIRT1 activation in vivo and in vitro

Xiao J, Sheng X, Zhang X, Guo M, Ji X

Drug Design, Development and Therapy 2016, 10:1267-1277

Published Date: 29 March 2016

Comparative efficacy of tamsulosin versus nifedipine for distal ureteral calculi: a meta-analysis

Wang H, Man LB, Huang GL, Li GZ, Wang JW

Drug Design, Development and Therapy 2016, 10:1257-1265

Published Date: 29 March 2016

Zolav®: a new antibiotic for the treatment of acne

Dinant A, Boulos RA

Drug Design, Development and Therapy 2016, 10:1235-1242

Published Date: 22 March 2016

The renoprotective effects of sulodexide

Olde Engberink RH, Vogt L

Drug Design, Development and Therapy 2016, 10:1233-1234

Published Date: 22 March 2016

Role of glycogen synthase kinase-3β inhibitor AZD1080 in ovarian cancer

Chen S, Sun KX, Feng MX, Sang XB, Liu BL, Zhao Y

Drug Design, Development and Therapy 2016, 10:1225-1232

Published Date: 18 March 2016

Effects of acute and chronic administration of neurosteroid dehydroepiandrosterone sulfate on neuronal excitability in mice

Svob Strac D, Vlainic J, Samardzic J, Erhardt J, Krsnik Z

Drug Design, Development and Therapy 2016, 10:1201-1215

Published Date: 21 March 2016

Computational and nonglycosylated systems: a simpler approach for development of nanosized PEGylated proteins

Mirzaei H, Kazemi B, Bandehpour M, Shoari A, Asgary V, Ardestani MS, Madadkar-Sobhani A, Ahangari Cohan R

Drug Design, Development and Therapy 2016, 10:1193-1200

Published Date: 16 March 2016

Sonodynamic effect of hematoporphyrin monomethyl ether on ligature-induced periodontitis in rats [Corrigendum]

Zhuang DS, Han JL, Bi LJ, Wang YP, Hao YR, Zhou Q, Cao WW

Drug Design, Development and Therapy 2016, 10:1191-1192

Published Date: 17 March 2016

Efficacy of BIBF 1120 or BIBF 1120 plus chemotherapy on nasopharyngeal carcinoma in vitro and in vivo

Xue C, Tian Y, Zhang J, Zhao Y, Zhan J, Fang W, Zhang L

Drug Design, Development and Therapy 2016, 10:1173-1180

Published Date: 15 March 2016

Toward antituberculosis drugs: in silico screening of synthetic compounds against Mycobacterium tuberculosis L,D-transpeptidase 2

Billones JB, Carrillo MCO, Organo VG, Macalino SJY, Sy JBA, Emnacen IA, Clavio NAB, Concepcion GP

Drug Design, Development and Therapy 2016, 10:1147-1157

Published Date: 11 March 2016

Synthesis, antimicrobial, and antiproliferative activities of substituted phenylfuranylnicotinamidines

Youssef MM, Arafa RK, Ismail MA,

Drug Design, Development and Therapy 2016, 10:1133-1146

Published Date: 11 March 2016

Selective use of sorafenib in the treatment of thyroid cancer

Pitoia F, Jerkovich F

Drug Design, Development and Therapy 2016, 10:1119-1131

Published Date: 11 March 2016

Formulation and clinical evaluation of silymarin pluronic-lecithin organogels for treatment of atopic dermatitis

Mady FM, Essa H, El-Ammawi T, Abdelkader H, Hussein AK

Drug Design, Development and Therapy 2016, 10:1101-1110

Published Date: 10 March 2016

Protective effects of honokiol on ischemia/reperfusion injury of rat ovary: an experimental study

Yaman Tunc S, Agacayak E, Goruk NY, Icen MS, Turgut A, Alabalik U, Togrul C, Ekinci C, Ekinci A, Gul T

Drug Design, Development and Therapy 2016, 10:1077-1083

Published Date: 8 March 2016

RGD(F/S/V)-Dex: towards the development of novel, effective, and safe glucocorticoids

Jiang X, Zhao M, Wang Y, Zhu H, Zhao S, Wu J, Song Y, Peng S

Drug Design, Development and Therapy 2016, 10:1059-1076

Published Date: 8 March 2016

Chloroquine enhances the efficacy of cisplatin by suppressing autophagy in human adrenocortical carcinoma treatment

Qin L, Xu TY, Xia LL, Wang XJ, Zhang X, Zhang XH, Zhu ZW, Zhong S, Wang CD, Shen ZJ

Drug Design, Development and Therapy 2016, 10:1035-1045

Published Date: 7 March 2016

Stability studies of lincomycin hydrochloride in aqueous solution and intravenous infusion fluids

Czarniak P, Boddy M, Sunderland B, Hughes JD

Drug Design, Development and Therapy 2016, 10:1029-1034

Published Date: 7 March 2016

Amsacrine analog-loaded solid lipid nanoparticle to resolve insolubility for injection delivery: characterization and pharmacokinetics

Fang YP, Chuang CH, Wu PC, Huang YB, Tzeng CC, Chen YL, Liu YT, Tsai YH, Tsai MJ

Drug Design, Development and Therapy 2016, 10:1019-1028

Published Date: 4 March 2016

Plasmodium-infected erythrocytes (pRBC) induce endothelial cell apoptosis via a heme-mediated signaling pathway

Liu M, Dickinson-Copeland C, Hassana S, Stiles JK

Drug Design, Development and Therapy 2016, 10:1009-1018

Published Date: 3 March 2016

Da0324, an inhibitor of nuclear factor-κB activation, demonstrates selective antitumor activity on human gastric cancer cells

Jin R, Xia Y, Chen Q, Li W, Chen D, Ye H, Zhao C, Du X, Shi D, Wu J, Liang G

Drug Design, Development and Therapy 2016, 10:979-995

Published Date: 2 March 2016

Eucommia bark (Du-Zhong) improves diabetic nephropathy without altering blood glucose in type 1-like diabetic rats

Niu HS, Liu IM, Niu CS, Ku PM, Hsu CT, Cheng JT

Drug Design, Development and Therapy 2016, 10:971-978

Published Date: 2 March 2016

Solubility enhancement of simvastatin by arginine: thermodynamics, solute–solvent interactions, and spectral analysis

Meor Mohd Affandi MMR, Tripathy M, Shah SAA, Majeed ABA

Drug Design, Development and Therapy 2016, 10:959-969

Published Date: 2 March 2016

Effects of Dang-Gui-Bu-Xue-Tang, an herbal decoction, on iron uptake in iron-deficient anemia

Huang GC, Chen SY, Tsai PW, Ganzon JG, Lee CJ, Shiah HS, Wang CC

Drug Design, Development and Therapy 2016, 10:949-957

Published Date: 2 March 2016

Effect of picroside II on erythrocyte deformability and lipid peroxidation in rats subjected to hind limb ischemia reperfusion injury

Çomu FM, Kılıç Y, Özer A, Kirişçi M, Dursun AD, Tatar T, Zor MH, Kartal H, Küçük A, Boyunağa H, Arslan M

Drug Design, Development and Therapy 2016, 10:927-931

Published Date: 1 March 2016

Naringenin-loaded solid lipid nanoparticles: preparation, controlled delivery, cellular uptake, and pulmonary pharmacokinetics

Ji P, Yu T, Liu Y, Jiang J, Xu J, Zhao Y, Hao Y, Qiu Y, Zhao W, Wu C

Drug Design, Development and Therapy 2016, 10:911-925

Published Date: 1 March 2016

The aqueous extract of Glycyrrhiza inflata can upregulate unfolded protein response-mediated chaperones to reduce tau misfolding in cell models of Alzheimer’s disease

Chang KH, Chen IC, Lin HY, Chen HC, Lin CH, Lin TH, Weng YT, Chao CY, Wu YR, Lin JY, Lee-Chen GJ, Chen CM

Drug Design, Development and Therapy 2016, 10:885-896

Published Date: 29 February 2016

Spotlight on lenvatinib in the treatment of thyroid cancer: patient selection and perspectives

Costa R, Carneiro BA, Chandra S, Pai SG, Chae YK, Kaplan JB, Garrett HB, Agulnik M, Kopp PA, Giles FJ

Drug Design, Development and Therapy 2016, 10:873-884

Published Date: 29 February 2016

The interplay of post-translational modification and gene therapy

Osamor VC, Chinedu SN, Azuh DE, Iweala EJ, Ogunlana OO

Drug Design, Development and Therapy 2016, 10:861-871

Published Date: 29 February 2016

Papaverine inhibits lipopolysaccharide-induced microglial activation by suppressing NF-κB signaling pathway

Dang Y, Mu Y, Wang K, Xu K, Yang J, Zhu Y, Luo B

Drug Design, Development and Therapy 2016, 10:851-859

Published Date: 26 February 2016

The mechanism underlying alpinetin-mediated alleviation of pancreatitis-associated lung injury through upregulating aquaporin-1

Liang XS, Zhang B, Chen Q, Zhang J, Lei B, Li B, Wei YC, Zhai R, Liang ZQ, He SQ, Tang B

Drug Design, Development and Therapy 2016, 10:841-850

Published Date: 24 February 2016

Total saponin of Dioscoreae hypoglaucae rhizoma ameliorates streptozotocin-induced diabetic nephropathy

Guo C, Ding G, Huang W, Wang Z, Meng Z, Xiao W

Drug Design, Development and Therapy 2016, 10:799-810

Published Date: 24 February 2016

Synergistic roles of p53 and HIF1α in human renal cell carcinoma-cell apoptosis responding to the inhibition of mTOR and MDM2 signaling pathways

Liu QJ, Shen HL, Lin J, Xu XH, Ji ZG, Han X, Shang DH, Yang PQ

Drug Design, Development and Therapy 2016, 10:745-755

Published Date: 18 February 2016

A network pharmacology approach to discover active compounds and action mechanisms of San-Cao Granule for treatment of liver fibrosis

Wei S, Niu M, Wang J, Wang J, Su H, Luo S, Zhang X, Guo Y, Liu L, Liu F, Zhao Q, Chen H, Xiao X, Zhao P, Zhao Y

Drug Design, Development and Therapy 2016, 10:733-743

Published Date: 19 February 2016

Treatment with a Ginkgo biloba extract, EGb 761, inhibits excitotoxicity in an animal model of spinocerebellar ataxia type 17

Huang DS, Lin HY, Lee-Chen GJ, Hsieh-Li HM, Wu CH, Lin JY

Drug Design, Development and Therapy 2016, 10:723-731

Published Date: 18 February 2016

Effects of 22 novel CYP2D6 variants found in Chinese population on the metabolism of dapoxetine

Xu RA, Gu EM, Zhou Q, Yuan LJ, Hu XX, Cai JP, Hu GX

Drug Design, Development and Therapy 2016, 10:687-696

Published Date: 15 February 2016

Long-term use of amiodarone before heart transplantation significantly reduces early post-transplant atrial fibrillation and is not associated with increased mortality after heart transplantation

Rivinius R, Helmschrott M, Ruhparwar A, Schmack B, Erbel C, Gleissner CA, Akhavanpoor M, Frankenstein L, Darche FF, Schweizer PA, Thomas D, Ehlermann P, Bruckner T, Katus HA, Doesch AO

Drug Design, Development and Therapy 2016, 10:677-686

Published Date: 16 February 2016

Drug-loaded erythrocytes: on the road toward marketing approval

Bourgeaux V, Lanao JM, Bax BE, Godfrin Y

Drug Design, Development and Therapy 2016, 10:665-676

Published Date: 11 February 2016

Therapeutic effects of tyroservatide on metastasis of lung cancer and its mechanism affecting integrin–focal adhesion kinase signal transduction

Huang YT, Zhao L, Fu Z, Zhao M, Song XM, Jia J, Wang S, Li JP, Zhu ZF, Lin G, Lu R, Yao Z

Drug Design, Development and Therapy 2016, 10:649-663

Published Date: 3 March 2016

Epigallocatechin-3-gallate attenuates apoptosis and autophagy in concanavalin A-induced hepatitis by inhibiting BNIP3

Li S, Xia Y, Chen K, Li J, Liu T, Wang F, Lu J, Zhou Y, Guo C

Drug Design, Development and Therapy 2016, 10:631-647

Published Date: 15 February 2016

Protective effect of fucoidan from Fucus vesiculosus on liver fibrosis via the TGF-β1/Smad pathway-mediated inhibition of extracellular matrix and autophagy

Li J, Chen K, Li S, Feng J, Liu T, Wang F, Zhang R, Xu S, Zhou Y, Zhou S, Xia Y, Lu J, Zhou Y, Guo C

Drug Design, Development and Therapy 2016, 10:619-630

Published Date: 12 February 2016

Randomized clinical trial: pharmacokinetics and safety of multimatrix mesalamine for treatment of pediatric ulcerative colitis

Cuffari C, Pierce D, Korczowski B, Fyderek K, Van Heusen H, Hossack S, Wan H, Edwards AY, Martin P

Drug Design, Development and Therapy 2016, 10:593-607

Published Date: 4 February 2016

Establishment of a novel therapeutic vector targeting the trigeminal ganglion in rats

Xu K, Pan SY, Song JX, ,Liu XN, An N, Zheng X

Drug Design, Development and Therapy 2016, 10:585-592

Published Date: 4 February 2016

miR-125b acts as a tumor suppressor in chondrosarcoma cells by the sensitization to doxorubicin through direct targeting the ErbB2-regulated glucose metabolism

Tang XY, Zheng W, Ding M, Guo KJ, Yuan F, Feng H, Deng B, Sun W, Hou Y, Gao L

Drug Design, Development and Therapy 2016, 10:571-583

Published Date: 24 February 2016

Curcumin enhances the cytogenotoxic effect of etoposide in leukemia cells through induction of reactive oxygen species

Papież MA, Krzyściak W, Szade K, Bukowska-Straková K, Kozakowska M, Hajduk K, Bystrowska B, Dulak J, Jozkowicz A

Drug Design, Development and Therapy 2016, 10:557-570

Published Date: 4 February 2016

Targeting the D1-N-methyl-D-aspartate receptor complex reduces L-dopa-induced dyskinesia in 6-hydroxydopamine-lesioned Parkinson’s rats

Song L, Zhang ZZ, Hu RG, Cheng J, Li L, Fan QY, Wu N, Gan J, Zhou MZ, Liu ZG

Drug Design, Development and Therapy 2016, 10:547-555

Published Date: 3 February 2016

Antiviral therapy: a perspective

Shahidi Bonjar AH

Drug Design, Development and Therapy 2016, 10:541-546

Published Date: 2 February 2016

Preparation and characterization of silymarin synchronized-release microporous osmotic pump tablets

Zeng QP, Liu ZH, Huang AW, Zhang J, Song HT

Drug Design, Development and Therapy 2016, 10:519-531

Published Date: 29 January 2016

Determination of the binding mode for anti-inflammatory natural product xanthohumol with myeloid differentiation protein 2

Fu W, Chen L, Wang Z, Zhao C, Chen G, Liu X, Dai Y, Cai Y, Li C, Zhou J, Liang G

Drug Design, Development and Therapy 2016, 10:455-463

Published Date: 27 January 2016

Amelioration of concanavalin A-induced autoimmune hepatitis by magnesium isoglycyrrhizinate through inhibition of CD4+CD25-CD69+ subset proliferation

Yang Q, Wang J, Liu R, Wang Z, Li Y, Zhang Y, Hao X, Huang Y, Xie W, Wei H

Drug Design, Development and Therapy 2016, 10:443-453

Published Date: 25 January 2016

Efficacy of trabectedin in advanced soft tissue sarcoma: beyond lipo- and leiomyosarcoma [Corrigendum]

De Sanctis R, Marrari A, Marchetti S, Mussi C, Balzarini L, Lutman FR, Daolio P, Bastoni S, Bertuzzi AF, Quagliuolo V, Santoro A

Drug Design, Development and Therapy 2016, 10:441-442

Published Date: 28 January 2016

In vitro stress effect on degradation and drug release behaviors of basic fibroblast growth factor – poly(lactic-co-glycolic-acid) microsphere

Xiong Y, Yu ZP, Lang Y, Hu JY, Li H, Yan YG, Tu CQ, Yang TF, Song YM, Duan H, Pei FX

Drug Design, Development and Therapy 2016, 10:431-440

Published Date: 25 January 2016

Formulation, optimization, and pharmacodynamic evaluation of chitosan/phospholipid/β-cyclodextrin microspheres

Shan L, Tao EX, Meng QH, Hou WX, Liu K, Shang HC, Tang JB, Zhang WF

Drug Design, Development and Therapy 2016, 10:417-429

Published Date: 25 January 2016

Depot injectable atorvastatin biodegradable in situ gel: development, optimization, in vitro, and in vivo evaluation

Ahmed TA, Alharby YA, El-Helw AM, Hosny KM, El-Say KM

Drug Design, Development and Therapy 2016, 10:405-415

Published Date: 20 January 2016

High-dose OxyContin to treat pain associated with bone metastasis in patients with small-cell lung cancer: a case study report

Zhou T, Zhang X, Dong Y, Zhuang FF, Jiang FQ, Yu JM, Zhang B

Drug Design, Development and Therapy 2016, 10:383-387

Published Date: 19 January 2016

Effects of probenecid and cimetidine on the pharmacokinetics of nemonoxacin in healthy Chinese volunteers

Zhang YF, Dai XJ, Yang Y, Chen XY, Wang T, Tang YB, Tsai CY, Chang LW, Chang YT, Zhong DF

Drug Design, Development and Therapy 2016, 10:357-370

Published Date: 20 January 2016

Clinical pharmacology study of cariprazine (MP-214) in patients with schizophrenia (12-week treatment)

Nakamura T, Kubota T, Iwakaji A, Imada M, Kapás M, Morio Y

Drug Design, Development and Therapy 2016, 10:327-338

Published Date: 14 January 2016

Evidence of the gastroprotective and anti-Helicobacter pylori activities of β-mangostin isolated from Cratoxylum arborescens (vahl) blume

Sidahmed HMA, Hashim NM, Mohan S, Abdelwahab SI, Taha MME, Dehghan F, Yahayu M, Ee GCL, Loke MF, Vadivelu J

Drug Design, Development and Therapy 2016, 10:297-313

Published Date: 13 January 2016

Liposomal flucytosine capped with gold nanoparticle formulations for improved ocular delivery

Salem HF, Ahmed SM, Omar MM

Drug Design, Development and Therapy 2016, 10:277-295

Published Date: 13 January 2016

Quetiapine monotherapy in acute treatment of generalized anxiety disorder: a systematic review and meta-analysis of randomized controlled trials

Maneeton N, Maneeton B, Woottiluk P, Likhitsathian S, Suttajit S, Boonyanaruthee V, Srisurapanont M

Drug Design, Development and Therapy 2016, 10:259-276

Published Date: 12 January 2016

A clinical prognostic scoring system for resectable gastric cancer to predict survival and benefit from paclitaxel- or oxaliplatin-based adjuvant chemotherapy

Qian J, Qian Y, Wang J, Gu B, Pei D, He S, Zhu F, Røe OD, Xu J, Liu L, Gu Y, Guo R, Yin Y, Shu Y, Chen X

Drug Design, Development and Therapy 2016, 10:241-258

Published Date: 24 February 2016

Pasireotide: a novel treatment for patients with acromegaly

Cuevas-Ramos D, Fleseriu M

Drug Design, Development and Therapy 2016, 10:227-239

Published Date: 11 January 2016

Spotlight on ixazomib: potential in the treatment of multiple myeloma

Muz B, Ghazarian RN, Ou M, Luderer MJ, Kusdono HD, Azab AK

Drug Design, Development and Therapy 2016, 10:217-226

Published Date: 11 January 2016

Preparation, characterization, and in vivo evaluation of intranasally administered liposomal formulation of donepezil

Al Asmari AK, Ullah Z, Tariq M, Fatani A

Drug Design, Development and Therapy 2016, 10:205-215

Published Date: 12 January 2016

Design and evaluation of novel interferon lambda analogs with enhanced antiviral activity and improved drug attributes

Yu D, Zhao M, Dong L, Zhao L, Zou M, Sun H, Zhang M, Liu H, Zou Z

Drug Design, Development and Therapy 2016, 10:163-182

Published Date: 6 January 2016

Isolation and evaluation of biological efficacy of quercetol in human hepatic carcinoma cells

Ali H, Dixit S, Ali D, Alkahtane AA, Alarifi S, Ali BA, Alkahtani S

Drug Design, Development and Therapy 2016, 10:155-162

Published Date: 6 January 2016

Self-emulsifying drug delivery systems as a tool to improve solubility and bioavailability of resveratrol

Balata GF, Essa EA, Shamardl HA, Zaidan SH, Abourehab MAS

Drug Design, Development and Therapy 2016, 10:117-128

Published Date: 5 January 2016

The gastroprotective effects of hydroalcoholic extract of Monolluma quadrangula against ethanol-induced gastric mucosal injuries in Sprague Dawley rats

Ibrahim IAA, Abdulla MA, Hajrezaie M, Bader A, Shahzad N, Al-Ghamdi SS, Gushash AS, Hasanpourghadi M

Drug Design, Development and Therapy 2016, 10:93-105

Published Date: 30 December 2015

Promoting effect of small molecules in cardiomyogenic and neurogenic differentiation of rat bone marrow-derived mesenchymal stem cells

Khanabdali R, Saadat A, Fazilah M, Bazli KFK, Qazi RM, Khalid RS, Hasan Adli DS, Moghadamtousi SZ, Naeem N, Khan I, Salim A, Shamsuddin SAA, Mohan G

Drug Design, Development and Therapy 2016, 10:81-91

Published Date: 24 December 2015

MicroRNA-125a-5p modulates human cervical carcinoma proliferation and migration by targeting ABL2

Qin X, Wan Y, Wang S, Xue M

Drug Design, Development and Therapy 2016, 10:71-79

Published Date: 24 December 2015

BCc1, the novel antineoplastic nanocomplex, showed potent anticancer effects in vitro and in vivo

Kalanaky S, Hafizi M, Fakharzadeh S, Vasei M, Langroudi L, Janzamin E, Hashemi SM, Khayamzadeh M, Soleimani M, Akbari ME, Nazaran MH

Drug Design, Development and Therapy 2016, 10:59-70

Published Date: 30 December 2015

MEK inhibitors and their potential in the treatment of advanced melanoma: the advantages of combination therapy

Tran KA, Cheng MY, Mitra A, Ogawa H, Shi VY, Olney LP, Kloxin AM, Maverakis E

Drug Design, Development and Therapy 2016, 10:43-52

Published Date: 21 December 2015

Modulation of neurotrophic signaling pathways by polyphenols

Moosavi F, Hosseini R, Saso L, Firuzi O

Drug Design, Development and Therapy 2016, 10:23-42

Published Date: 21 December 2015

Plasmid pORF-hTRAIL targeting to glioma using transferrin-modified polyamidoamine dendrimer

Gao S, Li J, Jiang C, Hong B, Hao B

Drug Design, Development and Therapy 2016, 10:1-11

Published Date: 17 December 2015

Brivaracetam: review of its pharmacology and potential use as adjunctive therapy in patients with partial onset seizures [Corrigendum]

Mumoli L, Palleria C, Gasparini S, Citraro R, Labate A, Ferlazzo E, Gambardella A, De Sarro G, Russo E

Drug Design, Development and Therapy 2015, 9:6509-6510

Published Date: 18 December 2015

Association of systolic blood pressure drop with intravenous administration of itraconazole in children with hemato-oncologic disease

Lee HJ, Lee B, Park JD, Jeong HJ, Choi YH, Ju HY, Hong CR, Lee JW, Kim H, Suh DI, Park KD, Kang HJ, Shin HY, Ahn HS

Drug Design, Development and Therapy 2015, 9:6489-6495

Published Date: 17 December 2015

Effect of caffeic acid phenethyl ester on bone formation in the expanded inter-premaxillary suture

Kazancioglu HO, Aksakalli S, Ezirganli S, Birlik M, Esrefoglu M, Acar AH

Drug Design, Development and Therapy 2015, 9:6483-6488

Published Date: 21 December 2015

Effects of vitamin C treatment on collar-induced intimal thickening

Arun MZ, Üstünes L, Sevin G, Özer E

Drug Design, Development and Therapy 2015, 9:6461-6473

Published Date: 15 December 2015

Enhanced antitumoral activity of doxorubicin against lung cancer cells using biodegradable poly(butylcyanoacrylate) nanoparticles

Melguizo C, Cabeza L, Prados J, Ortiz R, Caba O, Rama AR, Delgado ÁV, Arias JL

Drug Design, Development and Therapy 2015, 9:6433-6444

Published Date: 14 December 2015

Autophagy facilitates lung adenocarcinoma resistance to cisplatin treatment by activation of AMPK/mTOR signaling pathway

Wu T, Wang MC, Jing L, Liu ZY, Guo H, Liu Y, Bai YY, Cheng YZ, Nan KJ, Liang X

Drug Design, Development and Therapy 2015, 9:6421-6431

Published Date: 14 December 2015

Idiopathic pulmonary fibrosis: current treatment options and critical appraisal of nintedanib

Bonella F, Stowasser S, Wollin L

Drug Design, Development and Therapy 2015, 9:6407-6419

Published Date: 14 December 2015

Phase II trial of docetaxel combined with nedaplatin for patients with recurrent and metastatic nasopharyngeal carcinoma

Peng PJ, Lv BJ, Tang C, Liao H, Lin Z, Liu YM, Wang ZH, Wang SY, Cheng ZB

Drug Design, Development and Therapy 2015, 9:6401-6405

Published Date: 10 December 2015

Identification of covalent active site inhibitors of dengue virus protease

Koh-Stenta X, Joy J, Wang SF, Kwek PZ, Wee JLK, Wan KF, Gayen S, Chen AS, Kang C, Lee MA, Poulsen A, Vasudevan SG, Hill J, Nacro K

Drug Design, Development and Therapy 2015, 9:6389-6399

Published Date: 10 December 2015

Effect of oral N-acetylcysteine on COPD patients with microsatellite polymorphism in the heme oxygenase-1 gene promoter

Zhang JQ, Zhang JQ, Fang LZ, Liu L, Fu WP, Dai LM

Drug Design, Development and Therapy 2015, 9:6379-6387

Published Date: 7 December 2015

Effects of intravitreal injection of netrin-1 in retinal neovascularization of streptozotocin-induced diabetic rats

Yu Y, Zou J, Han Y, Quyang L, He H, Hu P, Shao Y, Tu P

Drug Design, Development and Therapy 2015, 9:6363-6377

Published Date: 7 December 2015

Tanshinone IIA ameliorates dextran sulfate sodium-induced inflammatory bowel disease via the pregnane X receptor

Zhang X, Wang Y, Ma Z, Liang Q, Tang X, Hu D, Tan H, Xiao C, Gao Y

Drug Design, Development and Therapy 2015, 9:6343-6362

Published Date: 7 December 2015

Hypoglycemic effect and mechanism of honokiol on type 2 diabetic mice

Sun J, Fu X, Liu Y, Wang Y, Huo B, Guo Y, Gao X, Li W, Hu X

Drug Design, Development and Therapy 2015, 9:6327-6342

Published Date: 4 December 2015

Green tea extract as a treatment for patients with wild-type transthyretin amyloidosis: an observational study

aus dem Siepen F, Bauer R, Aurich M, Buss SJ, Steen H, Altland K, Katus HA, Kristen AV

Drug Design, Development and Therapy 2015, 9:6319-6325

Published Date: 4 December 2015

Ginkgo biloba extract mitigates liver fibrosis and apoptosis by regulating p38 MAPK, NF-κB/IκBα, and Bcl-2/Bax signaling

Wang YY, Wang R, Wang YJ, Peng RQ, Wu Y, Yuan YF

Drug Design, Development and Therapy 2015, 9:6303-6317

Published Date: 3 December 2015

Synthetic biology for pharmaceutical drug discovery

Trosset JY, Carbonell P

Drug Design, Development and Therapy 2015, 9:6285-6302

Published Date: 3 December 2015

Sulodexide therapy for the treatment of diabetic nephropathy, a meta-analysis and literature review

Li R, Xing J, Mu XJ, Wang H, Zhang L, Zhao Y, Zhang Y

Drug Design, Development and Therapy 2015, 9:6275-6283

Published Date: 3 December 2015

Enzymatic vitreolysis with recombinant tissue plasminogen activator for vitreomacular traction

Raczyńska D, Lipowski P, Zorena K, Skorek A, Glasner P

Drug Design, Development and Therapy 2015, 9:6259-6268

Published Date: 27 November 2015

Timosaponin B-II ameliorates diabetic nephropathy via TXNI P, mTOR, and NF-κB signaling pathways in alloxan-induced mice

Yuan YL, Guo CR, Cui LL, Ruan SX, Zhang CF, Ji D, Yang ZL, Li F

Drug Design, Development and Therapy 2015, 9:6247-6258

Published Date: 27 November 2015

Hyaluronic acid abrogates ethanol-dependent inhibition of collagen biosynthesis in cultured human fibroblasts

Donejko M, Przylipiak A, Rysiak E, Miltyk W, Galicka E, Przylipiak J, Zaręba I, Surazynski A

Drug Design, Development and Therapy 2015, 9:6225-6233

Published Date: 24 November 2015

Different effects of statins on induction of diabetes mellitus: an experimental study

Zhao W, Zhao SP

Drug Design, Development and Therapy 2015, 9:6211-6223

Published Date: 24 November 2015

Radiotherapy potentiation with weekly cisplatin compared to standard every 3 weeks cisplatin chemotherapy for locoregionally advanced head and neck squamous cell carcinoma 

Fayette J, Molin Y, Lavergne E, Montbarbon X, Racadot S, Poupart M, Ramade A, Zrounba P, Ceruse P, Pommier P

Drug Design, Development and Therapy 2015, 9:6203-6210

Published Date: 26 November 2015

Synthesis, structural characterization, and anticancer activity of a monobenzyltin compound against MCF-7 breast cancer cells

Fani S, Kamalidehghan B, Lo KM, Hashim NM, Chow KM, Ahmadipour F

Drug Design, Development and Therapy 2015, 9:6191-6201

Published Date: 23 November 2015

Spotlight on tavaborole for the treatment of onychomycosis

Jinna S, Finch J

Drug Design, Development and Therapy 2015, 9:6185-6190

Published Date: 20 November 2015

Prospective study on nanoparticle albumin-bound paclitaxel in advanced breast cancer: clinical results and biological observations in taxane-pretreated patients

Fabi A, Giannarelli D, Malaguti P, Ferretti G, Vari S, Papaldo P, Nisticò C, Caterino M, De Vita R, Mottolese M, Iacorossi L, Cognetti F

Drug Design, Development and Therapy 2015, 9:6177-6183

Published Date: 20 November 2015

Influence of glucosamine on the bioactivity of insulin delivered subcutaneously and in an oral nanodelivery system

Al-Kurdi ZI, Chowdhry BZ, Leharne SA, Qinna NA, Al Omari MMH, Badwan AA

Drug Design, Development and Therapy 2015, 9:6167-6176

Published Date: 19 November 2015

Efficacy and safety of a conversion from the original tacrolimus and mycophenolate mofetil to the generics Tacpan® and Mowel® after liver transplantation

Vollmar J, Bellmann MC, Darstein F, Hoppe-Lotichius M, Mittler J, Heise M, Rüttger B, Weyer V, Zimmermann A, Lang H, Galle PR, Zimmermann T

Drug Design, Development and Therapy 2015, 9:6139-6149

Published Date: 17 November 2015

DNAzyme-based probe for circulating microRNA detection in peripheral blood

Shao G, Ji S, Wu A, Liu C, Wang M, Zhang P, Jiao Q, Kang Y

Drug Design, Development and Therapy 2015, 9:6109-6117

Published Date: 16 November 2015

Protective effects of triptolide on retinal ganglion cells in a rat model of chronic glaucoma

Yang F, Wang DM, Wu LL, Li Y

Drug Design, Development and Therapy 2015, 9:6095-6107

Published Date: 16 November 2015

Apatinib for molecular targeted therapy in tumor

Zhang H

Drug Design, Development and Therapy 2015, 9:6075-6081

Published Date: 13 November 2015

A single-arm Phase II validation study of preventing oxaliplatin-induced hypersensitivity reactions by dexamethasone: the AVOID trial

Yoshida Y, Hirata K, Matsuoka H, Iwamoto S, Kotaka M, Fujita H, Aisu N, Hoshino S, Kosaka T, Maeda K, Kiyomi F, Yamashita Y

Drug Design, Development and Therapy 2015, 9:6067-6073

Published Date: 12 November 2015

Attenuation of myocardial fibrosis with curcumin is mediated by modulating expression of angiotensin II AT1/AT2 receptors and ACE2 in rats

Pang XF, Zhang LH, Bai F, Wang NP, Garner RE, McKallip RJ, Zhao ZQ

Drug Design, Development and Therapy 2015, 9:6043-6054

Published Date: 11 November 2015

Profile of suvorexant in the management of insomnia

Sutton EL

Drug Design, Development and Therapy 2015, 9:6035-6042

Published Date: 11 November 2015

6-Gingerol alleviates exaggerated vasoconstriction in diabetic rat aorta through direct vasodilation and nitric oxide generation

Ghareib SA, El-Bassossy HM, Elberry AA, Azhar A, Watson ML, Banjar ZM

Drug Design, Development and Therapy 2015, 9:6019-6026

Published Date: 9 November 2015

Glucose abnormalities in Asian patients with chronic hepatitis C

Bo Q, Orsenigo R, Wang J, Griffel L, Brass C

Drug Design, Development and Therapy 2015, 9:6009-6017

Published Date: 9 November 2015

Progesterone regulates the proliferation of breast cancer cells – in vitro evidence

Azeez JM, Sithul H, Hariharan I, Sreekumar S, Prabhakar J, Sreeja S, Pillai MR

Drug Design, Development and Therapy 2015, 9:5987-5999

Published Date: 9 November 2015

Phytocompounds and modulatory effects of Anacardium microcarpum (cajui) on antibiotic drugs used in clinical infections

Barbosa-Filho VM, Waczuk EP, Leite NF, Menezes IRA, da Costa JGM, Lacerda SR, Adedara IA, Coutinho HDM, Posser T, Kamdem JP

Drug Design, Development and Therapy 2015, 9:5965-5972

Published Date: 6 November 2015

Lentinus squarrosulus (Mont.) mycelium enhanced antioxidant status in rat model

Mhd Omar NA, Abdullah S, Abdullah N, Kuppusamy UR, Abdulla MA, Sabaratnam V

Drug Design, Development and Therapy 2015, 9:5957-5964

Published Date: 6 November 2015

Tumor-induced VEGF-C overexpression in retroperitoneal lymph nodes in VX2 carcinoma-bearing rabbits

Huang YW, Zhou Y, Lan CY, Wang Y, Feng YL, Luo RZ, Liu JH

Drug Design, Development and Therapy 2015, 9:5949-5956

Published Date: 5 November 2015

Systematic review and meta-analysis: bezafibrate in patients with primary biliary cirrhosis [Erratum]

Yin Q, Li J, Xia Y, Zhang R, Wang J, Lu W, Zhou Y, Zheng Y, Abudumijiti H, Chen R, Chen K, Li S, Liu T, Wang F, Lu J, Zhou Y, Guo C

Drug Design, Development and Therapy 2015, 9:5947-5948

Published Date: 9 November 2015

Efficacy and safety of ifosfamide-based chemotherapy for osteosarcoma: a meta-analysis

Fan XL, Cai GP, Zhu LL, Ding GM

Drug Design, Development and Therapy 2015, 9:5925-5932

Published Date: 4 November 2015

PACE4 regulates apoptosis in human prostate cancer cells via endoplasmic reticulum stress and mitochondrial signaling pathways

Yao Z, Sun B, Hong Q, Yan J, Mu D, Li J, Sheng H, Guo H

Drug Design, Development and Therapy 2015, 9:5911-5923

Published Date: 5 November 2015

Critical appraisal of Timothy grass pollen extract GRAZAX® in the management of allergic rhinitis

Scaparrotta A, Attanasi M, Petrosino MI, Di Filippo P, Di Pillo S, Chiarelli F

Drug Design, Development and Therapy 2015, 9:5897-5909

Published Date: 3 November 2015

In silico approach for the discovery of new PPARγ modulators among plant-derived polyphenols

Encinar JA, Fernández-Ballester G, Galiano-Ibarra V, Micol V

Drug Design, Development and Therapy 2015, 9:5877-5895

Published Date: 4 November 2015

Efficacy and tolerability of oral oxycodone and oxycodone/naloxone combination in opioid-naïve cancer patients: a propensity analysis

Lazzari M, Greco MT, Marcassa C, Finocchi S, Caldarulo C, Corli O

Drug Design, Development and Therapy 2015, 9:5863-5872

Published Date: 2 November 2015

Arsenic sulfide combined with JQ1, chemotherapy agents, or celecoxib inhibit gastric and colon cancer cell growth

Zhang L, Tong Y, Zhang X, Pan M, Chen S

Drug Design, Development and Therapy 2015, 9:5851-5862

Published Date: 30 October 2015

The relevance of piroxicam for the prevention and treatment of nonmelanoma skin cancer and its precursors

Campione E, Paternò EJ, Candi E, Falconi M, Costanza G, Diluvio L, Terrinoni A, Bianchi L, Orlandi A

Drug Design, Development and Therapy 2015, 9:5843-5850

Published Date: 29 October 2015

Prevalence of the rs7903146C>T polymorphism in TCF7L2 gene for prediction of type 2 diabetes risk among Iranians of different ethnicities

Allahdini M, Kamalidehghan B, Akbari L, Azadfar P, Rahmani A, Ahmadipour F, Meng GY, Masserrat A, Houshmand M

Drug Design, Development and Therapy 2015, 9:5835-5841

Published Date: 28 October 2015

Development of oral dispersible tablets containing prednisolone nanoparticles for the management of pediatric asthma

Chen YD, Liang ZY, Cen YY, Zhang H, Han MG, Tian YQ, Zhang J, Li SJ, Yang DS

Drug Design, Development and Therapy 2015, 9:5815-5825

Published Date: 20 November 2015

Curcuma purpurascens BI. rhizome accelerates rat excisional wound healing: involvement of Hsp70/Bax proteins, antioxidant defense, and angiogenesis activity

Rouhollahi E, Moghadamtousi SZ, Hajiaghaalipour F, Zahedifard M, Tayeby F, Awang K, Abdulla MA, Mohamed Z

Drug Design, Development and Therapy 2015, 9:5805-5813

Published Date: 27 October 2015

Empagliflozin in the treatment of type 2 diabetes: evidence to date

Shubrook JH, Baradar Bokaie B, Adkins SE

Drug Design, Development and Therapy 2015, 9:5793-5803

Published Date: 30 October 2015

Efficacy of trabectedin in advanced soft tissue sarcoma: beyond lipo- and leiomyosarcoma

De Sanctis R, Marrari A, Marchetti S, Mussi C, Balzarini L, Lutman FR, Daolio P, Bastoni S, Bertuzzi AF, Quagliuolo V, Santoro A

Drug Design, Development and Therapy 2015, 9:5785-5791

Published Date: 27 October 2015

Reductive metabolism of oxymatrine is catalyzed by microsomal CYP3A4

Liu W, Shi J, Zhu L, Dong L, Luo F, Zhao M, Wang Y, Hu M, Lu L, Liu Z

Drug Design, Development and Therapy 2015, 9:5771-5783

Published Date: 30 October 2015

Rationale and clinical utility of the darunavir–cobicistat combination in the treatment of HIV/AIDS

Putcharoen O, Do T, Avihingsanon A, Ruxrungtham K

Drug Design, Development and Therapy 2015, 9:5763-5769

Published Date: 23 October 2015

Efficacy of thrombomodulin for acute exacerbation of idiopathic pulmonary fibrosis and nonspecific interstitial pneumonia: a nonrandomized prospective study

Abe M, Tsushima K, Matsumura T, Ishiwata T, Ichimura Y, Ikari J, Terada J, Tada Y, Sakao S, Tanabe N, Tatsumi K

Drug Design, Development and Therapy 2015, 9:5755-5762

Published Date: 23 October 2015

Mechanism and pharmacological rescue of berberine-induced hERG channel deficiency

Yan M, Zhang KP, Shi YH, Feng LF, Lv L, Li BX

Drug Design, Development and Therapy 2015, 9:5737-5747

Published Date: 22 October 2015

4-Hydroxyisoleucine ameliorates an insulin resistant-like state in 3T3-L1 adipocytes by regulating TACE/TIMP3 expression

Gao F, Du W, Zafar MI, Shafqat RA, Jian L, Cai Q, Lu FR

Drug Design, Development and Therapy 2015, 9:5727-5736

Published Date: 20 October 2015

Brivaracetam: review of its pharmacology and potential use as adjunctive therapy in patients with partial onset seizures

Mumoli L, Palleria C, Gasparini S, Citraro R, Labate A, Ferlazzo E, Gambardella A, De Sarro G, Russo E

Drug Design, Development and Therapy 2015, 9:5719-5725

Published Date: 19 October 2015

Evaluation of the cardiovascular effects of varenicline in rats

Selçuk EB, Sungu M, Parlakpinar H, Ermiş N, Taslıdere E, Vardı N, Yalçınsoy M, Sagır M, Polat A, Karatas M, Kayhan-Tetik B

Drug Design, Development and Therapy 2015, 9:5705-5717

Published Date: 22 October 2015

Safety and pharmacokinetics of dicloxacillin in healthy Chinese volunteers following single and multiple oral doses

Wu GL, Zheng YL, Zhou HL, Hu XJ, Liu J, Zhai Y, Zhu MX, Wu LH, Shentu JZ

Drug Design, Development and Therapy 2015, 9:5687-5695

Published Date: 16 October 2015

Bifunctional fused polypeptide inhibits the growth and metastasis of breast cancer

Liang AL, Qian HL, Zhang TT, Zhou N, Wang HJ, Men XT, Qi W, Zhang PP, Fu M, Liang X, Lin C, Liu YJ

Drug Design, Development and Therapy 2015, 9:5671-5686

Published Date: 16 October 2015

The role of taxanes in triple-negative breast cancer: literature review [Corrigendum]

Mustacchi G, De Laurentiis M

Drug Design, Development and Therapy 2015, 9:5669-5670

Published Date: 19 October 2015

Adenoviral delivery of truncated MMP-8 fused with the hepatocyte growth factor mutant 1K1 ameliorates liver cirrhosis and promotes hepatocyte proliferation

Liu JH, Li JB, Fu WW, Tang JC, Feng X, Chen J, Liang YL, Jin RA, Xie AY, Cai XJ

Drug Design, Development and Therapy 2015, 9:5655-5667

Published Date: 16 October 2015

Development of PPAR-agonist GW0742 as antidiabetic drug: study in animals

Niu HS, Ku PM, Niu CS, Cheng JT, Lee KS

Drug Design, Development and Therapy 2015, 9:5625-5632

Published Date: 14 October 2015

Paeoniflorin inhibits human glioma cells via STAT3 degradation by the ubiquitin–proteasome pathway

Nie XH, Ou-yang J, Xing Y, Li DY, Dong XY, Liu RE, Xu RX

Drug Design, Development and Therapy 2015, 9:5611-5622

Published Date: 13 October 2015

Urinary kallidinogenase for the treatment of cerebral arterial stenosis

Zhao L, Zhao Y, Wan Q, Zhang H

Drug Design, Development and Therapy 2015, 9:5595-5600

Published Date: 13 October 2015

Acquired latent tuberculosis infection in psoriasis patients treated with etanercept in the People’s Republic of China

Li CR, Mao QX, Chen M, Jia WX, Yao X, Feng SY, Jia H, Gong JQ, Yang XY

Drug Design, Development and Therapy 2015, 9:5591-5594

Published Date: 12 October 2015

Arsenic sulfide inhibits cell migration and invasion of gastric cancer in vitro and in vivo

Zhang L, Kim S, Ding W, Tong Y, Zhang X, Pan M, Chen S

Drug Design, Development and Therapy 2015, 9:5579-5590

Published Date: 9 October 2015

Novel dehydroepiandrosterone troche supplementation improves the serum androgen profile of women undergoing in vitro fertilization

Keane KN, Hinchliffe PM, Namdar N, Conceicao JL, Newsholme P, Yovich JL

Drug Design, Development and Therapy 2015, 9:5569-5578

Published Date: 9 October 2015

Design, synthesis, and antitumor evaluation of histone deacetylase inhibitors with L-phenylglycine scaffold

Zhang Y, Li X, Hou J, Huang Y, Xu W

Drug Design, Development and Therapy 2015, 9:5553-5567

Published Date: 8 October 2015

Plumbagin suppresses epithelial to mesenchymal transition and stemness via inhibiting Nrf2-mediated signaling pathway in human tongue squamous cell carcinoma cells

Pan ST, Qin Y, Zhou ZW, He ZX, Zhang X, Yang T, Yang YX, Wang D, Zhou SF, Qiu JX

Drug Design, Development and Therapy 2015, 9:5511-5551

Published Date: 5 October 2015

Neuroprotective potential of ferulic acid in the rotenone model of Parkinson’s disease

Ojha S, Javed H, Azimullah S, Abul Khair SB, Haque ME

Drug Design, Development and Therapy 2015, 9:5499-5510

Published Date: 7 October 2015

3-Coumaranone derivatives as inhibitors of monoamine oxidase

Van Dyk AS, Petzer JP, Petzer A, Legoabe LJ

Drug Design, Development and Therapy 2015, 9:5479-5489

Published Date: 3 October 2015

A novel small-molecule inhibitor of HIV-1 entry

Heredia A, Latinovic OS, Barbault F, de Leeuw EPH

Drug Design, Development and Therapy 2015, 9:5469-5478

Published Date: 1 October 2015

Maraviroc: a review of its use in HIV infection and beyond

Woollard SM, Kanmogne GD

Drug Design, Development and Therapy 2015, 9:5447-5468

Published Date: 1 October 2015

A proposal for an individualized pharmacogenetic-guided isoniazid dosage regimen for patients with tuberculosis

Jung JA, Kim TE, Lee H, Jeong BH, Park HY, Jeon K, Kwon OJ, Ko JW, Choi R, Woo HI, Koh WJ, Lee SY

Drug Design, Development and Therapy 2015, 9:5433-5438

Published Date: 30 September 2015

Systematic review and meta-analysis: bezafibrate in patients with primary biliary cirrhosis

Yin Q, Li J, Xia Y, Zhang R, Wang J, Lu W, Zhou Y, Zheng Y, Abudumijiti H, Chen R, Chen K, Li S, Liu T, Wang F, Lu J, Zhou Y, Guo C

Drug Design, Development and Therapy 2015, 9:5407-5419

Published Date: 30 September 2015

Ghrelin reduces liver impairment in a model of concanavalin A-induced acute hepatitis in mice

Mao YQ, Wang JB, Yu FJ, Cheng J, Li HQ, Guo CY, Fan XM

Drug Design, Development and Therapy 2015, 9:5385-5396

Published Date: 28 September 2015

Collagenase IV plays an important role in regulating hair cycle by inducing VEGF, IGF-1, and TGF-β expression

Hou C, Miao Y, Wang J, Wang X, Chen CY, Hu ZQ

Drug Design, Development and Therapy 2015, 9:5373-5383

Published Date: 25 September 2015

Efficacy and safety of a vaginal medicinal product containing three strains of probiotic bacteria: a multicenter, randomized, double-blind, and placebo-controlled trial

Tomusiak A, Strus M, Heczko PB, Adamski P, Stefański G, Mikołajczyk-Cichońska A, Suda-Szczurek M

Drug Design, Development and Therapy 2015, 9:5345-5354

Published Date: 25 September 2015

Effect of curcumin on aging retinal pigment epithelial cells

Zhu W, Wu Y, Meng YF, Wang JY, Xu M, Tao JJ, Lu J

Drug Design, Development and Therapy 2015, 9:5337-5344

Published Date: 25 September 2015

Investigation of the bioequivalence of montelukast chewable tablets after a single oral administration using a validated LC-MS/MS method

Zaid AN, Abualhasan MN, Watson DG, Mousa A, Ghazal N, Bustami R

Drug Design, Development and Therapy 2015, 9:5315-5321

Published Date: 23 September 2015

Chamaejasmin B exerts anti-MDR effect in vitro and in vivo via initiating mitochondria-dependant intrinsic apoptosis pathway

Wang YJ, Li Q, Xiao HB, Li YJ, Yang Q, Kan XX, Chen Y, Liu XN, Weng XG, Chen X, Cai WY, Guo Y, Huang HF, Zhu XX

Drug Design, Development and Therapy 2015, 9:5301-5313

Published Date: 22 September 2015

The rapid effects of budesonide plus formoterol in patients with obstructive airway diseases

Bayiz H, Ozkaya S, Dirican A, Ece F

Drug Design, Development and Therapy 2015, 9:5287-5290

Published Date: 21 September 2015

Exposure–outcome analysis in depressed patients treated with paroxetine using population pharmacokinetics

Kim JR, Woo HI, Chun MR, Lim SW, Kim HD, Na HS, Chung MW, Myung W, Lee SY, Kim DK

Drug Design, Development and Therapy 2015, 9:5247-5254

Published Date: 16 September 2015

Companion diagnostics and molecular imaging-enhanced approaches for oncology clinical trials

Van Heertum RL, Scarimbolo R, Ford R, Berdougo E, O’Neal M

Drug Design, Development and Therapy 2015, 9:5215-5223

Published Date: 11 September 2015

Eliglustat tartrate for the treatment of adults with type 1 Gaucher disease [Corrigendum]

Bennett LL, Turcotte K

Drug Design, Development and Therapy 2015, 9:5213-5214

Published Date: 11 September 2015

Dabigatran etexilate retards the initiation and progression of atherosclerotic lesions and inhibits the expression of oncostatin M in apolipoprotein E-deficient mice

Preusch MR, Ieronimakis N, Wijelath ES, Cabbage S, Ricks J, Bea F, Reyes M, van Ryn J, Rosenfeld ME

Drug Design, Development and Therapy 2015, 9:5203-5211

Published Date: 10 September 2015

Pentoxifylline and electromagnetic field improved bone fracture healing in rats

Atalay Y, Gunes N, Guner MD, Akpolat V, Celik MS, Guner R

Drug Design, Development and Therapy 2015, 9:5195-5201

Published Date: 9 September 2015

Exposure–response model for sibutramine and placebo: suggestion for application to long-term weight-control drug development

Han S, Jeon S, Hong T, Lee J, Bae SH, Park WS, Park G, Youn S, Jang DY, Kim KS, Yim DS

Drug Design, Development and Therapy 2015, 9:5185-5194

Published Date: 9 September 2015

Regulation of bone formation by baicalein via the mTORC1 pathway

Li SF, Tang JJ, Chen J, Zhang P, Wang T, Chen TY, Yan B, Huang B, Wang L, Huang MJ, Zhang ZM, Jin DD

Drug Design, Development and Therapy 2015, 9:5169-5183

Published Date: 9 September 2015

The IL-17A G-197A and IL-17F 7488T/C polymorphisms are associated with increased risk of cancer in Asians: a meta-analysis

Wang H, Zhang Y, Liu Z, Zhang Y, Zhao H, Du S

Drug Design, Development and Therapy 2015, 9:5159-5168

Published Date: 24 September 2015

Icariside II ameliorates diabetic nephropathy in streptozotocin-induced diabetic rats

Tian W, Lei H, Guan R, Xu Y, Li H, Wang L, Yang B, Gao Z, Xin Z

Drug Design, Development and Therapy 2015, 9:5147-5157

Published Date: 7 September 2015

Novel synthesizing method of pH-dependent doxorubicin-loaded anti-CD22-labelled drug delivery nanosystem

Sun M, Wang J, Lu Q, Xia G, Zhang Y, Song L, Fang Y

Drug Design, Development and Therapy 2015, 9:5123-5133

Published Date: 7 September 2015

Anthocyanins inhibit high-glucose-induced cholesterol accumulation and inflammation by activating LXRα pathway in HK-2 cells

Du C, Shi Y, Ren Y, Wu H, Yao F, Wei J, Wu M, Hou Y, Duan H

Drug Design, Development and Therapy 2015, 9:5099-5113

Published Date: 4 September 2015

Phase III study of pasireotide long-acting release in patients with metastatic neuroendocrine tumors and carcinoid symptoms refractory to available somatostatin analogues

Wolin EM, Jarzab B, Eriksson B, Walter T, Toumpanakis C, Morse MA, Tomassetti P, Weber MM, Fogelman DR, Ramage J, Poon D, Gadbaw B, Li J, Pasieka JL, Mahamat A, Swahn F, Newell-Price J, Mansoor W, Öberg K

Drug Design, Development and Therapy 2015, 9:5075-5086

Published Date: 3 September 2015

Paeonia lactiflora Pall. protects against ANIT-induced cholestasis by activating Nrf2 via PI3K/Akt signaling pathway

Ma X, Zhao Y, Zhu Y, Chen Z, Wang J, Li R, Chen C, Wei S, Li J, Liu B, Wang R, Li Y, Wang L, Xiao X

Drug Design, Development and Therapy 2015, 9:5061-5074

Published Date: 2 September 2015

Inhibition of HIV-1 by curcumin A, a novel curcumin analog

Kumari N, Kulkarni AA, Lin X, McLean C, Ammosova T, Ivanov A, Hipolito M, Nekhai S, Nwulia E

Drug Design, Development and Therapy 2015, 9:5051-5060

Published Date: 3 September 2015

Pharmacokinetic and nephroprotective benefits of using Schisandra chinensis extracts in a cyclosporine A-based immune-suppressive regime

Lai Q, Wei JB, Mahmoodurrahman M, Zhang CX, Quan SJ, Li TM, Yu Y

Drug Design, Development and Therapy 2015, 9:4997-5018

Published Date: 28 August 2015

CXCR4 in breast cancer: oncogenic role and therapeutic targeting

Xu C, Zhao H, Chen H, Yao Q

Drug Design, Development and Therapy 2015, 9:4953-4964

Published Date: 28 August 2015

Insight into the mechanism of polyphenols on the activity of HMGR by molecular docking

Islam B, Sharma C, Adem A, Aburawi EH, Ojha S

Drug Design, Development and Therapy 2015, 9:4943-4951

Published Date: 28 August 2015

The effect of curcumin and its nanoformulation on adjuvant-induced arthritis in rats

Zheng ZL, Sun YH, Liu ZL, Zhang MQ, Li CQ, Cai H

Drug Design, Development and Therapy 2015, 9:4931-4942

Published Date: 27 August 2015

Immunosuppressive effects of the standardized extract of Phyllanthus amarus on cellular immune responses in Wistar-Kyoto rats

Ilangkovan M, Jantan I, Mesaik MA, Bukhari SNA

Drug Design, Development and Therapy 2015, 9:4917-4930

Published Date: 26 August 2015

Profile of omalizumab in the treatment of chronic spontaneous urticaria

Labrador-Horrillo M, Ferrer M

Drug Design, Development and Therapy 2015, 9:4909-4915

Published Date: 25 August 2015

Met tyrosine kinase inhibitor, PF-2341066, suppresses growth and invasion of nasopharyngeal carcinoma

Zhao Y, Zhang J, Tian Y, Xue C, Hu Z, Zhang L

Drug Design, Development and Therapy 2015, 9:4897-4907

Published Date: 26 August 2015

Hydrogen sulfide-releasing naproxen suppresses colon cancer cell growth and inhibits NF-κB signaling

Kodela R, Nath N, Chattopadhyay M, Nesbitt DE, Velázquez-Martínez CA, Kashfi K

Drug Design, Development and Therapy 2015, 9:4873-4882

Published Date: 24 August 2015

Blood pyrrole-protein adducts as a diagnostic and prognostic index in pyrrolizidine alkaloid-hepatic sinusoidal obstruction syndrome

Gao H, Ruan JQ, Chen J, Li N, Ke CQ, Ye Y, Lin G, Wang JY

Drug Design, Development and Therapy 2015, 9:4861-4868

Published Date: 25 August 2015

Nonalcoholic steatohepatitis: emerging targeted therapies to optimize treatment options

Milic S, Mikolasevic I, Krznaric-Zrnic I, Stanic M, Poropat G, Stimac D, Vlahovic-Palcevski V, Orlic L

Drug Design, Development and Therapy 2015, 9:4835-4845

Published Date: 20 August 2015

How we make cell therapy in Italy

Montemurro T, Viganò M, Budelli S, Montelatici E, Lavazza C, Marino L, Parazzi V, Lazzari L, Giordano R

Drug Design, Development and Therapy 2015, 9:4825-4834

Published Date: 20 August 2015

Role of short-acting nitroglycerin in the management of ischemic heart disease

Boden WE, Padala SK, Cabral KP, Buschmann IR, Sidhu MS

Drug Design, Development and Therapy 2015, 9:4793-4805

Published Date: 19 August 2015

High glucose inhibits ClC-2 chloride channels and attenuates cell migration of rat keratinocytes

Pan F, Guo R, Cheng W, Chai L, Wang W, Cao C, Li S

Drug Design, Development and Therapy 2015, 9:4779-4791

Published Date: 28 August 2015

Effects of chalcone derivatives on players of the immune system

Lee JS, Bukhari SNA, Fauzi NM

Drug Design, Development and Therapy 2015, 9:4761-4778

Published Date: 19 August 2015

Death receptor and mitochondria-mediated hepatocyte apoptosis underlies liver dysfunction in rats exposed to organic pollutants from drinking water

Yang GH, Zhou ZW, Cen YL, Gui XL, Zeng QB, Ao YX, Li Q, Wang SR, Li J, Zhang AH

Drug Design, Development and Therapy 2015, 9:4719-4733

Published Date: 18 August 2015

Development of telmisartan in the therapy of spinal cord injury: pre-clinical study in rats

Lin CM, Tsai JT, Chang CK, Cheng JT, Lin JW

Drug Design, Development and Therapy 2015, 9:4709-4717

Published Date: 14 August 2015

Paget’s disease of bone: an osteoimmunological disorder?

Numan MS, Amiable N, Brown JP, Michou L

Drug Design, Development and Therapy 2015, 9:4695-4707

Published Date: 14 August 2015

Enhancement of absorption and bioavailability of echinacoside by verapamil or clove oil

Shen JY, Yang XL, Yang ZL, Kou JP, Li F

Drug Design, Development and Therapy 2015, 9:4685-4693

Published Date: 14 August 2015

Treatment with metformin and a dipeptidyl peptidase-4 inhibitor elevates apelin levels in patients with type 2 diabetes mellitus

Fan YJ, Zhang Y, Li XS, Zheng H, Song YP, Zhang N, Shen CF, Fan XF, Ren FD, Shen JY, Ren GG, Yang JL

Drug Design, Development and Therapy 2015, 9:4679-4683

Published Date: 14 August 2015

Lefty-1 alleviates TGF-β1-induced fibroblast–myofibroblast transdifferentiation in NRK-49F cells

Zhang LJ, Zhang J, Xu CG, Zhou XJ, Wang W, Zheng RP, Hu W, Wu P

Drug Design, Development and Therapy 2015, 9:4669-4678

Published Date: 14 August 2015

Myofibrotic malformation vessels: unique angiodysplasia toward the progression of hemorrhoidal disease

Li SL, Jing FY, Ma LL, Guo LL, Na F, An SL, Ye Y, Yang JM, Bao M, Kang D, Sun XL, Deng YJ

Drug Design, Development and Therapy 2015, 9:4649-4656

Published Date: 13 August 2015

Eliglustat tartrate for the treatment of adults with type 1 Gaucher disease

Bennett LL, Turcotte K

Drug Design, Development and Therapy 2015, 9:4639-4647

Published Date: 18 August 2015

PTEN insufficiency modulates ER+ breast cancer cell cycle progression and increases cell growth in vitro and in vivo

Chiang KC, Chen HY, Hsu SY, Pang JHS, Wang SY, Hsu JT, Yeh TS, Chen LW, Kuo SF, Sun CC, Lee JM, Yeh CN, Juang HH

Drug Design, Development and Therapy 2015, 9:4631-4638

Published Date: 13 August 2015

RGD-modified liposomes enhance efficiency of aclacinomycin A delivery: evaluation of their effect in lung cancer

Feng C, Li X, Dong C, Zhang X, Zhang X, Gao Y

Drug Design, Development and Therapy 2015, 9:4613-4620

Published Date: 11 August 2015

Relaxin inhibits cardiac fibrosis and endothelial–mesenchymal transition via the Notch pathway

Zhou X, Chen X, Cai JJ, Chen LZ, Gong YS, Wang LX, Gao Z, Zhang HQ, Huang WJ, Zhou H

Drug Design, Development and Therapy 2015, 9:4599-4611

Published Date: 11 August 2015

Ceftobiprole for the treatment of pneumonia: a European perspective

Liapikou A, Cillóniz C, Torres A

Drug Design, Development and Therapy 2015, 9:4565-4572

Published Date: 18 August 2015

Effects of amoxicillin/clavulanic acid on the pharmacokinetics of valproic acid

Lee SY, Huh W, Jung JA, Yoo HM, Ko JW, Kim JR

Drug Design, Development and Therapy 2015, 9:4559-4563

Published Date: 10 August 2015

Navigating the chemical space of dipeptidyl peptidase-4 inhibitors

Shoombuatong W, Prachayasittikul V, Anuwongcharoen N, Songtawee N, Monnor T, Prachayasittikul S, Prachayasittikul V, Nantasenamat C

Drug Design, Development and Therapy 2015, 9:4515-4549

Published Date: 10 August 2015

Clinical development of galunisertib (LY2157299 monohydrate), a small molecule inhibitor of transforming growth factor-beta signaling pathway

Herbertz S, Sawyer JS, Stauber AJ, Gueorguieva I, Driscoll KE, Estrem ST, Cleverly AL, Desaiah D, Guba SC, Benhadji KA, Slapak CA, Lahn MM

Drug Design, Development and Therapy 2015, 9:4479-4499

Published Date: 10 August 2015

Novel targeting of PEGylated liposomes for codelivery of TGF-β1 siRNA and four antitubercular drugs to human macrophages for the treatment of mycobacterial infection: a quantitative proteomic study

Niu NK, Yin JJ, Yang YX, Wang ZL, Zhou ZW, He ZX, Chen XW, Zhang XJ, Duan W, Yang TX, Zhou SF

Drug Design, Development and Therapy 2015, 9:4441-4470

Published Date: 7 August 2015

Transarterial chemoembolization versus hepatic resection in hepatocellular carcinoma treatment: a meta-analysis

Tian X, Dai Y, Wang D, Zhang L, Sui C, Meng F, Jiang S, Liu Y, Jiang Y

Drug Design, Development and Therapy 2015, 9:4431-4440

Published Date: 10 August 2015

High-throughput sequencing of 16S rDNA amplicons characterizes bacterial composition in cerebrospinal fluid samples from patients with purulent meningitis

Liu A, Wang C, Liang Z, Zhou ZW, Wang L, Ma Q, Wang G, Zhou SF, Wang Z

Drug Design, Development and Therapy 2015, 9:4417-4429

Published Date: 7 August 2015

Tongguan capsule ameliorates coronary artery stenosis in a 40-year-old woman

Ma H, Wang L, Huang DZ, Liu GQ, Zhang MZ

Drug Design, Development and Therapy 2015, 9:4413-4416

Published Date: 10 August 2015

High-throughput virtual screening with e-pharmacophore and molecular simulations study in the designing of pancreatic lipase inhibitors

Veeramachaneni GK, Raj KK, Chalasani LM, Bondili JS, Talluri VR

Drug Design, Development and Therapy 2015, 9:4397-4412

Published Date: 6 August 2015

The role of aflibercept in the management of diabetic macular edema

Chang AA, Hong T, Ewe SY, Bahrami B, Broadhead GK

Drug Design, Development and Therapy 2015, 9:4389-4396

Published Date: 6 August 2015

Gamma scintigraphic evaluation of floating gastroretentive tablets of metformin HCl using a combination of three natural polymers in rabbits

Razavi M, Karimian H, Yeong CH, Chung LY, Nyamathulla S, Noordin MI

Drug Design, Development and Therapy 2015, 9:4373-4386

Published Date: 6 August 2015

The role of taxanes in triple-negative breast cancer: literature review

Mustacchi G, De Laurentiis M

Drug Design, Development and Therapy 2015, 9:4303-4318

Published Date: 5 August 2015

Hidden costs of antiretroviral treatment: the public health efficiency of drug packaging

Andreu-Crespo À, Llibre JM, Cardona-Peitx G, Sala-Piñol F, Clotet B, Bonafont-Pujol X

Drug Design, Development and Therapy 2015, 9:4287-4290

Published Date: 5 August 2015

Development of megestrol acetate solid dispersion nanoparticles for enhanced oral delivery by using a supercritical antisolvent process

Ha ES, Kim JS, Baek I, Yoo JW, Jung Y, Moon HR, Kim MS

Drug Design, Development and Therapy 2015, 9:4269-4277

Published Date: 4 August 2015

Design, synthesis, and anti-melanogenic effects of (E)-2-benzoyl-3-(substituted phenyl)acrylonitriles

Yun HY, Kim DH, Son S, Ullah S, Kim SJ, Kim YJ, Yoo JW, Jung YJ, Chun P, Moon HR

Drug Design, Development and Therapy 2015, 9:4259-4268

Published Date: 4 August 2015

Colon-targeted delivery of piceatannol enhances anti-colitic effects of the natural product: potential molecular mechanisms for therapeutic enhancement

Yum S, Jeong S, Lee S, Nam J, Kim W, Yoo JW, Kim MS, Lee BL, Jung Y

Drug Design, Development and Therapy 2015, 9:4247-4258

Published Date: 4 August 2015

Advances in cancer pain from bone metastasis

Zhu XC, Zhang JL, Ge CT, Yu YY, Wang P, Yuan TF, Fu CY

Drug Design, Development and Therapy 2015, 9:4239-4245

Published Date: 18 August 2015

Evaluation of glycine-bearing celecoxib derivatives as a colon-specific mutual prodrug acting on nuclear factor-κB, an anti-inflammatory target

Lee S, Lee Y, Kim W, Nam J, Jeong S, Yoo JW, Kim MS, Moon HR, Jung Y

Drug Design, Development and Therapy 2015, 9:4227-4237

Published Date: 7 August 2015

Characterization of cubosomes as a targeted and sustained transdermal delivery system for capsaicin

Peng X, Zhou Y, Han K, Qin L, Dian L, Li G, Pan X, Wu C

Drug Design, Development and Therapy 2015, 9:4209-4218

Published Date: 3 August 2015