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Drug Design, Development and Therapy

ISSN: 1177-8881

Journal Articles:

- 5,731 records -

Clinical Trial Report

The Effect of Food on the Pharmacokinetics and Gastrointestinal Tolerability of Bersiporocin, a Novel Oral Prolyl-tRNA-Synthetase Inhibitor

Lee S, Kwak Y, Park J, Park Y, Yu KS, Oh J

Drug Design, Development and Therapy 2026, 20:609676

Published Date: 17 July 2026

Clinical Trial Report

Comparison of the ED90 of Esketamine for Suppressing Laryngeal Mask Airway Insertion Responses During Propofol Induction with or without Intravenous Lidocaine Pretreatment: A Randomized Double-Blind Dose-Finding Trial

Zhang L, Zhang L, Wang J, Diao S, Liu Y, Shi J

Drug Design, Development and Therapy 2026, 20:609448

Published Date: 16 July 2026

Original Research

Safety of Short-T erm Low-Dose Olanzapine in Patients with Cancer and Diabetes Receiving Cisplatin-Based Chemotherapy: A Retrospective TriNetX Cohort Study

Hayashi T, Shiraishi C, Abe M, Kaneshige S, Egawa T

Drug Design, Development and Therapy 2026, 20:615968

Published Date: 16 July 2026

Clinical Trial Report

The Effect of Esketamine on Peripheral Vascular Resistance in Elderly Patients During Anesthesia Induction: A Single-Center, Double-Blind, Prospective, Randomized Controlled Study

Li J, Gao Y, Jing K, Lu H, Cao Y, Chen X, Wang H, Song X, Gan G, Tan S

Drug Design, Development and Therapy 2026, 20:607757

Published Date: 16 July 2026

Review

Bicaudal‑C1 in Cancer: Molecular Mechanisms and Therapeutic Strategies Integrating Chinese and Western Medicine

Jiang X, Qi Y, Yan J, Liu Y, Huang X, Li Y, Li Y, Song Z, Zhang L, Zhang Z

Drug Design, Development and Therapy 2026, 20:606851

Published Date: 15 July 2026

Original Research

Obinutuzumab as a Rescue and Maintenance Strategy in Children with Difficult-to-Treat Nephrotic Syndrome After Rituximab-Based Treatment Failure or Intolerance: A Preliminary Single-Center Real-World Retrospective Study

Sun H, Guo L, Shao P, Liang W, Ma X, He Y, Qiu L

Drug Design, Development and Therapy 2026, 20:619807

Published Date: 15 July 2026

Original Research

Early Detection and Temporal Progression of Hemidiaphragmatic Paralysis After Supraclavicular Brachial Plexus Block with 20 mL vs 30 mL Ropivacaine: A Randomized Controlled Trial

Bao X, He Z, Ma Y, Xu S, Hu B, Ma Y, Fang Y, Zhu W, Kang X

Drug Design, Development and Therapy 2026, 20:598288

Published Date: 15 July 2026

Original Research

Comparative Risk of Psoriatic Arthritis in Type 2 Diabetes: An Emulated Target Trial of SGLT2 Inhibitors vs. GLP-1 Receptor Agonists

Yen FS, Wang SI, Hwu CM, Chen KY, Hsu CC, Wei JCC

Drug Design, Development and Therapy 2026, 20:614222

Published Date: 15 July 2026

Letter

Methodological Concerns Regarding ED95 Estimation and Outcome Interpretation in the Remimazolam Dose-Finding Study for HIFU Ablation [Letter]

Yu S, Meng J, Li J

Drug Design, Development and Therapy 2026, 20:637737

Published Date: 14 July 2026

Original Research

Real-World Comparative Weight Loss of GLP-1 Receptor Agonists in the All of Us Research Program: A Retrospective Cohort Study

Hwang I, Lee SW, Kim Y

Drug Design, Development and Therapy 2026, 20:604247

Published Date: 14 July 2026

Review

Targeting Bruton’s Tyrosine Kinase (BTK) in Autoimmunity: Achievements, Opportunities and Challenges

Torke S, Dybowski S, Weber MS

Drug Design, Development and Therapy 2026, 20:568214

Published Date: 14 July 2026

Clinical Trial Report

Effect of Oliceridine on the Acute Postoperative Pain Management After Elective Cesarean Delivery: A Randomized Non-Inferiority Trial

Jiang J, Yuan G, Shi Y, Zhou Z, Wang X, Sang X, Zhang X

Drug Design, Development and Therapy 2026, 20:603352

Published Date: 14 July 2026

Review

Tumor Assembloids as Three-Dimensional Platforms for Modeling Drug Delivery Barriers: Construction Strategies, Applications, and Translational Challenges

Zhang J, Luo X, Sun Z, Jin B, Zhao Y

Drug Design, Development and Therapy 2026, 20:618870

Published Date: 14 July 2026

Original Research

Oliceridine versus Sufentanil on Postoperative Nausea and Vomiting in Women Undergoing Gynecological Laparoscopic Surgery: A Randomized Double‑Blind Controlled Trial

Liu F, Liu N, Wang X, Liu Z, Tao Z, Yuan Q, Zhang Y, Guan Z, Shen W, Tang B, Liu Z, Yang L

Drug Design, Development and Therapy 2026, 20:621409

Published Date: 14 July 2026

Clinical Trial Report

Perioperative Butorphanol for the Prevention of Postoperative Pulmonary Complications After Thoracoscopic Lung Resection: A Randomized, Double-Blind, Placebo-Controlled Trial

Wang X, Zhang Y, Wu Y, Yin T, Xia J, Zhao L, Zeng S, Wu K, Sun J, Liu S

Drug Design, Development and Therapy 2026, 20:621698

Published Date: 14 July 2026

Clinical Trial Report

Dexamethasone Alone versus Combined with Droperidol for Preventing Postoperative Nausea and Vomiting in Gynecological Day Surgery Under Ciprofol-Alfentanil Anesthesia: A Randomized Double-Blind Controlled Trial

Sun X, Xiao H, Li M, Yin B, Yu S, Ji F, Shan J

Drug Design, Development and Therapy 2026, 20:625824

Published Date: 14 July 2026

Original Research

The MEC90 of Ropivacaine for Ultrasound-Guided Pectoral Nerve Block Type II for Modified Radical Mastectomy: A Biased-Coin Up-and-Down Sequential Trial

Du Y, Liu W, Wu Y, Ma L, Tang Y, Wang J

Drug Design, Development and Therapy 2026, 20:612421

Published Date: 13 July 2026

Original Research

0.06% Ropivacaine Combined with Double-Hole Dural Puncture Epidural Analgesia in Labor for Primiparous Women: A Prospective Randomized Controlled Trial

Piao G, Li H, Jin S, Feng L, Zhao Y, Jiang M, Zhou T, Jin M

Drug Design, Development and Therapy 2026, 20:617452

Published Date: 10 July 2026

Letter

Cataract as an Endpoint-Dependent Confounder in Trials of Neuroprotective Therapies for Glaucoma [Letter]

Yang D, Zou J

Drug Design, Development and Therapy 2026, 20:635506

Published Date: 10 July 2026

Original Research

Ultrasound-Guided Femoral Nerve Block with Esketamine Adjuvant for Postoperative Analgesia in Total Knee Arthroplasty–A Randomized, Double-Blind, Controlled Trial

Cheng Z, Hong L, Wang Y, Wang P

Drug Design, Development and Therapy 2026, 20:609966

Published Date: 10 July 2026

Clinical Trial Report

Phase I Study Evaluating Pharmacokinetics, Pharmacodynamics, Safety, and Immunogenicity of Recombinant Human Serum Albumin (rHSA) in Healthy Adults

Panuganti VK, Dundigalla MR, Grandhi VR, Khambhampaty S, Madala PK, Mohammad J, Shaik A, Shaik MB, KSSVV S, Sangeetham SK

Drug Design, Development and Therapy 2026, 20:598274

Published Date: 10 July 2026

Response to Letter

Effects of Remimazolam Dose and Bolus Injection Rate on Hiccups During Painless Colonoscopy: A Double-Blind Randomized Clinical Trial [Response to Letter]

Lu Y, Wang X, Zou H, Shao C, Lai G, Ou S

Drug Design, Development and Therapy 2026, 20:632112

Published Date: 10 July 2026

Clinical Trial Report

Induction of General Anesthesia with Fospropofol in Elderly Patients Undergoing Hip Surgery: An Efficacy and Safety Analysis

Wu Y, Liao W, Zheng Y, Li L, Chang Q, Huang L, Qiu L

Drug Design, Development and Therapy 2026, 20:610270

Published Date: 10 July 2026

Letter

Semaglutide in Diabetic Periodontitis-Induced Osteoblast Ferroptosis: Pharmacological and Methodological Insights [Letter]

Dong Y

Drug Design, Development and Therapy 2026, 20:637327

Published Date: 10 July 2026

Letter

The Concentration Paradox: When Dose-Response Logic Collapses in a Photoaging Study [Letter]

Xiao Z, Tan Y

Drug Design, Development and Therapy 2026, 20:637244

Published Date: 10 July 2026

Letter

Beyond Pleiotropy: A Call for Target Deconvolution and Chemopreventive Repositioning of Alkaloids in CRC [Letter]

Wang Z, Tan X

Drug Design, Development and Therapy 2026, 20:634308

Published Date: 10 July 2026

Original Research

From Initiation to Recovery: A Longitudinal Analysis of Polymyxin B-Induced Kidney Injury in Clinical Practice

Zhang GX, Zhang MR, Qu Q, Yi SM, Zhang YT, Wang YM, Qu J

Drug Design, Development and Therapy 2026, 20:613715

Published Date: 9 July 2026

Review

Precision Endocrine-Based Combinations After CDK4/6 Inhibitor Progression in HR-Positive Metastatic Breast Cancer

Abdel-Razeq H

Drug Design, Development and Therapy 2026, 20:611371

Published Date: 9 July 2026

Expression of Concern

Aceclofenac Nanocrystals with Enhanced in vitro, in vivo Performance: Formulation Optimization, Characterization, Analgesic and Acute Toxicity Studies [Expression of Concern]

Rahim H, Sadiq A, Khan S, Khan MA, Shah SMH, Hussain Z, Ullah R, Shahat AA, Ibrahim K

Drug Design, Development and Therapy 2026, 20:636789

Published Date: 9 July 2026

Retraction

MicroRNA-125a-5p Modulates Human Cervical Carcinoma Proliferation and Migration by Targeting ABL2 [Retraction]

Qin X, Wan Y, Wang S, Xue M

Drug Design, Development and Therapy 2026, 20:636791

Published Date: 9 July 2026

Letter