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Drug Design, Development and Therapy
ISSN: 1177-8881
- View all (4258)
- Volume 18, 2024 (218)
- Volume 17, 2023 (283)
- Volume 16, 2022 (316)
- Volume 15, 2021 (399)
- Volume 14, 2020 (477)
- Volume 13, 2019 (387)
- Volume 12, 2018 (382)
- Volume 11, 2017 (330)
- Volume 10, 2016 (374)
- Volume 9, 2015 (543)
- Volume 8, 2014 (231)
- Volume 7, 2013 (143)
- Volume 6, 2012 (42)
- Volume 5, 2011 (40)
- Volume 4, 2010 (35)
- Volume 3, 2009 (27)
- Volume 2, 2008 (29)
- Volume 1, 2007 (1)
Journal Articles:
- 4,257 records -
Lawsone Unleashed: A Comprehensive Review on Chemistry, Biosynthesis, and Therapeutic Potentials
Nair AS, Sekar M, Gan SH, Kumarasamy V, Subramaniyan V, Wu YS, Mat Rani NNI, Ravi S, Wong LS
Drug Design, Development and Therapy 2024, 18:3295-3313
Published Date: 26 July 2024
Therapeutic Effects of Qingchang Tongluo Decoction on Intestinal Fibrosis in Crohn’s Disease: Network Pharmacology, Molecular Docking and Experiment Validation
Li Y, Hu J, Au R, Cheng C, Xu F, Li W, Wu Y, Cui Y, Zhu L, Shen H
Drug Design, Development and Therapy 2024, 18:3269-3293
Published Date: 25 July 2024
Antitumor Effects of Hydromorphone on Human Gastric Cancer Cells in vitro [Retraction]
Liang B, Li C, Zhou Z, Xie Y
Drug Design, Development and Therapy 2024, 18:3267-3268
Published Date: 25 July 2024
Research Progress of Triptolide Against Fibrosis
Jiang M, Xie Y, Wang P, Du M, Wang Y, Yan S
Drug Design, Development and Therapy 2024, 18:3255-3266
Published Date: 25 July 2024
Flavonoids and Gastric Cancer Therapy: From Signaling Pathway to Therapeutic Significance
Cai J, Tan X, Hu Q, Pan H, Zhao M, Guo C, Zeng J, Ma X, Zhao Y
Drug Design, Development and Therapy 2024, 18:3233-3253
Published Date: 25 July 2024
Chuanxiong Renshen Decoction Inhibits Alzheimer’s Disease Neuroinflammation by Regulating PPARγ/NF-κB Pathway
Hou J, Wang X, Zhang J, Shen Z, Li X, Yang Y
Drug Design, Development and Therapy 2024, 18:3209-3232
Published Date: 24 July 2024
Unraveling Crucial Mitochondria-Related Genes in the Transition from Ulcerative Colitis to Colorectal Cancer
Wang F, Xie L, Tang Y, Deng T
Drug Design, Development and Therapy 2024, 18:3175-3189
Published Date: 24 July 2024
Co-Expression Network Analysis and Molecular Docking Demonstrate That Diosgenin Inhibits Gastric Cancer Progression via SLC1A5/mTORC1 Pathway
Cui N, Ding F
Drug Design, Development and Therapy 2024, 18:3157-3173
Published Date: 23 July 2024
Morin Regulates M1/M2 Microglial Polarization via NF-κB p65 to Alleviate Vincristine-Induced Neuropathic Pain
Shao Y, Chen Y, Lan X, Lu J, Tang G, Tang S, Zhai R, Chen C, Xiong X, Shi J
Drug Design, Development and Therapy 2024, 18:3143-3156
Published Date: 22 July 2024
Integrating Network Pharmacology with in vitro Experiments to Validate the Efficacy of Celastrol Against Hepatocellular Carcinoma Through Ferroptosis
Cai B, Qi M, Zhang X, Zhang D
Drug Design, Development and Therapy 2024, 18:3121-3141
Published Date: 22 July 2024
Effect of Efavirenz on the Pharmacokinetics of SHR6390 in Healthy Volunteers
Wang J, Hu C, Zhang L
Drug Design, Development and Therapy 2024, 18:3113-3119
Published Date: 19 July 2024
Study on the Underlying Mechanism of Yinhua Gout Granules in the Treatment of Gouty Arthritis by Integrating Transcriptomics and Network Pharmacology
Fan QQ, Zhai BT, Zhang D, Zhang XF, Cheng JX, Guo DY, Tian H
Drug Design, Development and Therapy 2024, 18:3089-3112
Published Date: 19 July 2024
The Discovery of GIT1/β-Pix Inhibitors: Virtual Screening and Biological Evaluation of New Small-molecule Compounds with Anti-invasion Effect in Gastrointestinal Neoplasms
Wang C, Gu J, Li H, Zhao B, Yu T, Guo CL, Huang M, Jiang W, Ouyang Q
Drug Design, Development and Therapy 2024, 18:3075-3088
Published Date: 16 July 2024
Therapeutic Potential of Solanum Alkaloids with Special Emphasis on Cancer: A Comprehensive Review
Manoharan R, Nair CS, Eissa N, Cheng H, Ge P, Ren M, Jaleel A
Drug Design, Development and Therapy 2024, 18:3063-3074
Published Date: 16 July 2024
Mapping Theme Trends and Research Frontiers in Dexmedetomidine Over Past Decade: A Bibliometric Analysis
Chen Z, Zuo Z, Song X, Zuo Y, Zhang L, Ye Y, Ma Y, Pan L, Zhao X, Jin Y
Drug Design, Development and Therapy 2024, 18:3043-3061
Published Date: 16 July 2024
Evaluating the Therapeutic Potential of Ublituximab in the Treatment of MS: Design, Development and Place in Therapy
Martin SJ, Guenette M, Oh J
Drug Design, Development and Therapy 2024, 18:3025-3042
Published Date: 16 July 2024
The Application Potential of the Regulation of Tregs Function by Irisin in the Prevention and Treatment of Immune-Related Diseases
Wang Z, Xu J, Mo L, Zhan R, Zhang J, Liu L, Jiang J, Zhang Y, Bai Y
Drug Design, Development and Therapy 2024, 18:3005-3023
Published Date: 16 July 2024
Nootkatone Counteracts Melamine-Mediated Nephrotoxicity via Modulation of Intermediate Filament Proteins, Oxidative, Inflammatory, and Apoptotic Events
Abdelrahaman D, Habotta OA, Ateya A, Aldarmahi AA, El-Shafei RA, Badawy MM, El-Mansy AA, A-Elgadir TM, Nada AM, Elhadidy MG, Hamza E, Alwutayed KM, El-Sherbiny M, Fericean L, Imbrea F, Abdeen A
Drug Design, Development and Therapy 2024, 18:2989-3004
Published Date: 16 July 2024
Neuroprotective Mechanism of MOTS-c in TBI Mice: Insights from Integrated Transcriptomic and Metabolomic Analyses
Li F, Jia Y, Fang J, Gong L, Zhang Y, Wei S, Wu L, Jiang P
Drug Design, Development and Therapy 2024, 18:2971-2987
Published Date: 15 July 2024
Tangzhiping Decoction Improves Glucose and Lipid Metabolism and Exerts Protective Effects Against White Adipose Tissue Dysfunction in Prediabetic Mice
Wang C, An T, Lu C, Liu T, Shan X, Zhu Z, Gao Y
Drug Design, Development and Therapy 2024, 18:2951-2969
Published Date: 15 July 2024
Nanoparticle-Based Drug Delivery Systems for Inflammatory Bowel Disease Treatment
Gao J, Li J, Luo Z, Wang H, Ma Z
Drug Design, Development and Therapy 2024, 18:2921-2949
Published Date: 15 July 2024
Clinical Study of Flumazenil Antagonizing Remimazolam on Nausea and Vomiting After Gynecologic Day Surgery [Letter]
Satici MH, Altay N
Drug Design, Development and Therapy 2024, 18:2919-2920
Published Date: 11 July 2024
Oral Bioavailability, Tissue Distribution, Metabolism, and Excretion of Panduratin A from Boesenbergia rotunda Extract in Healthy Rats
Kongratanapasert T, Boonyarattanasoonthorn T, Supannapan K, Hongeng S, Khemawoot P
Drug Design, Development and Therapy 2024, 18:2905-2917
Published Date: 11 July 2024
Pharmacokinetics and Safety of Estradiol Valerate Tablet and Its Generic: A Phase 1 Bioequivalence Study in Healthy Chinese Postmenopausal Female Subjects
Zhang L, Li M, Fan L, Liu F, Zhang P, Huang Q, Mai G, Shentu J
Drug Design, Development and Therapy 2024, 18:2891-2904
Published Date: 10 July 2024
The Influence of Piriform Recess Instillation with Lidocaine Before Bronchoscopy on Post-General Anesthesia Cough: A Randomized Controlled Trial
Min K, Wang Y, Feng D, Jin T, Zhu W, Duan R, Lv X
Drug Design, Development and Therapy 2024, 18:2883-2890
Published Date: 9 July 2024
Integrating Network Pharmacology, Transcriptomics to Reveal Neuroprotective of Curcumin Activate PI3K / AKT Pathway in Parkinson’s Disease
Cai B, Wang Q, Zhong L, Liu F, Wang X, Chen T
Drug Design, Development and Therapy 2024, 18:2869-2881
Published Date: 9 July 2024
Exploration of Berberine Against Ulcerative Colitis via TLR4/NF-κB/HIF-1α Pathway by Bioinformatics and Experimental Validation
Li J, Dan W, Zhang C, Liu N, Wang Y, Liu J, Zhang S
Drug Design, Development and Therapy 2024, 18:2847-2868
Published Date: 9 July 2024
Nalbuphine in Pediatric Emergence Agitation Following Cochlear Implantation: A Randomized Trial
Li Y, Li Q, Zhao G, Zhang H, Zhong H, Zeng Y
Drug Design, Development and Therapy 2024, 18:2837-2845
Published Date: 8 July 2024
The Efficacy of Letrozole Co-Treatment in an Antagonist Protocol for Women with Polycystic Ovary Syndrome Undergoing IVF: A Retrospective Study
Lin J, Wu F, Zhu Y, Zhu Q, Du T, Lin J
Drug Design, Development and Therapy 2024, 18:2823-2835
Published Date: 8 July 2024
Determination of ED90s of Phenylephrine and Norepinephrine Infusion for Prevention of Spinal Anesthesia-Induced Hypotension in Patients with Preeclampsia During Cesarean Delivery
Tan H, Chen Y, Jiang Y, Sun X, Ye W, Zhu X, Xiong X
Drug Design, Development and Therapy 2024, 18:2813-2821
Published Date: 5 July 2024
Inflammation Can Be a High-Risk Factor for Mucosal Nonunion of MRONJ by Regulating SIRT1 Signaling When Treated with an Oncologic Dose of Zoledronate
Zhu S, Cui Y, Zhang W, Ji Y, Li L, Luo S, Cui J, Li M
Drug Design, Development and Therapy 2024, 18:2793-2812
Published Date: 4 July 2024
Thymopentapeptide Affects T-Cell Subsets by Modulating the Flora of the Skin Surface to Alleviate Psoriasis
Liu X, Xi R, Du X, Wang Y, Cheng L, Yan G, Lu H, Liu T, Li F
Drug Design, Development and Therapy 2024, 18:2775-2791
Published Date: 4 July 2024
Clinical Efficacy of Taxol Plus Platinum (TP) Chemotherapy Combined with Delayed Administration of PD-1 Inhibitors in Patients with Locally Advanced, Recurrent or Metastatic Esophageal Squamous Cell Carcinoma: A Retrospective Study
Shen L, Chen Z, Zhang Z, Wu Y, Ren Y, Li Y, Li Y, Yin X, Han F, Chen Y
Drug Design, Development and Therapy 2024, 18:2761-2773
Published Date: 3 July 2024
Schisandra chinensis Bee Pollen Extract Inhibits Proliferation and Migration of Hepatocellular Carcinoma HepG2 Cells via Ferroptosis-, Wnt-, and Focal Adhesion–Signaling Pathways
Li Z, Yang J, Sun Y, Han S, Gong J, Zhang Y, Feng Z, Yao H, Shi P
Drug Design, Development and Therapy 2024, 18:2745-2760
Published Date: 2 July 2024
Pharmacokinetics and Safety of Oliceridine Fumarate Injection in Chinese Patients with Chronic Non-Cancer Pain: A Phase I, Single-Ascending-Dose, Open-Label Clinical Trial
Ni Y, Huang R, Yang S, Yang XY, Zeng S, Yao A, Huang J, Yang G
Drug Design, Development and Therapy 2024, 18:2729-2743
Published Date: 3 July 2024
Advances in Research on the Effectiveness and Mechanism of Active Ingredients from Traditional Chinese Medicine in Regulating Hepatic Stellate Cells Autophagy Against Hepatic Fibrosis
Liu XY, Zhang W, Ma BF, Sun MM, Shang QH
Drug Design, Development and Therapy 2024, 18:2715-2727
Published Date: 2 July 2024
4-Amino-2-Trifluoromethyl-Phenyl Retinate Inhibits Proliferation, Invasion, and Migration of Breast Cancer Cells by Independently Regulating CRABP2 and FABP5 [Retraction]
Ju J, Wang N, Wang J, Wu F, Ge J, Chen F
Drug Design, Development and Therapy 2024, 18:2713-2714
Published Date: 3 July 2024
Costunolide Inhibits Chronic Kidney Disease Development by Attenuating IKKβ/NF-κB Pathway
Zhao Y, Wang YH, Tu WC, Wang DW, Lu MJ, Shao Y
Drug Design, Development and Therapy 2024, 18:2693-2712
Published Date: 2 July 2024
Etomidate Combined with Propofol versus Remimazolam for Sedation in Elderly Patients During Gastrointestinal Endoscopy: A Randomized Prospective Clinical Trial
Zhang Q, Zhao R, Wu Y, Zhang L, Feng Y
Drug Design, Development and Therapy 2024, 18:2681-2692
Published Date: 2 July 2024
Evaluation of a Covalent Library of Diverse Warheads (CovLib) Binding to JNK3, USP7, or p53
Klett T, Schwer M, Ernst LN, Engelhardt MU, Jaag SJ, Masberg B, Knappe C, Lämmerhofer M, Gehringer M, Boeckler FM
Drug Design, Development and Therapy 2024, 18:2653-2679
Published Date: 1 July 2024
Pharmacokinetic Interactions Between the Fixed-Dose Combination of Ezetimibe/Rosuvastatin 10/20 Mg and the Fixed-Dose Combination of Telmisartan/Amlodipine 80/5 Mg in Healthy Subjects
Ryu H, Kim HC, Jeon I, Jang IJ, Cho JY, Kim KT, Oh J
Drug Design, Development and Therapy 2024, 18:2641-2652
Published Date: 1 July 2024
Integration of Gut Microbiota, Serum Metabolomic, and Network Pharmacology to Reveal the Anti Insomnia Mechanism of Mongolian Medicine Sugemule-4 Decoction on Insomnia Model Rats
Du L, Yang D, Wu L, Mei L, Wu S, Ba Y, Bao Y, Su R, Song L
Drug Design, Development and Therapy 2024, 18:2617-2639
Published Date: 27 June 2024
Up-and-Down Determination of Different Crystalloid Coload Volumes on the ED 90 of Prophylactic Norepinephrine Infusion for Preventing Postspinal Anesthesia Hypotension During Cesarean Section
Chen Y, Xiong X, Qin R, Guo L, Shi Y, Ni X
Drug Design, Development and Therapy 2024, 18:2609-2616
Published Date: 26 June 2024
A Health Technology Assessment Based on Chinese Guideline: Active Vitamin D and Its Analogs in the Treatment of Osteoporosis
Huang S, Li J, Hu X, Chen J
Drug Design, Development and Therapy 2024, 18:2593-2608
Published Date: 26 June 2024
A Visual Analysis of the Research Dynamics in Resistance to EGFR Inhibitors for NSCLC
Shao J, Gu Y, Guo R, Xu J
Drug Design, Development and Therapy 2024, 18:2571-2591
Published Date: 26 June 2024
Clinical Pharmacokinetics of Semaglutide: A Systematic Review
Yang XD, Yang YY
Drug Design, Development and Therapy 2024, 18:2555-2570
Published Date: 25 June 2024
Anti-Infection of Oral Microorganisms from Herbal Medicine of Piper crocatum Ruiz & Pav
Kurnia D, Lestari S, Mayanti T, Gartika M, Nurdin D
Drug Design, Development and Therapy 2024, 18:2531-2553
Published Date: 25 June 2024
Ferroptosis in Cancer Therapy: Mechanisms, Small Molecule Inducers, and Novel Approaches
Luo Y, Bai XY, Zhang L, Hu QQ, Zhang N, Cheng JZ, Hou MZ, Liu XL
Drug Design, Development and Therapy 2024, 18:2485-2529
Published Date: 21 June 2024
Comparison of Ciprofol-Based and Propofol-Based Total Intravenous Anesthesia on Microvascular Decompression of Facial Nerve with Neurophysiological Monitoring: A Randomized Non-Inferiority Trial
Zhu T, Kang F, Han MM, He F, Jiang S, Hao LN, Huang X, Li J
Drug Design, Development and Therapy 2024, 18:2475-2484
Published Date: 21 June 2024
Short–Term Preconditioning with Insulin and Glucose Efficiently Protected the Kidney Against Ischemia-Reperfusion Injury via the P-AKT-Bax-Caspase-3 Signaling Pathway in Mice
Sun L, Bing H, Zhang C, Lin L, Lian H, Chu Q, Jin X
Drug Design, Development and Therapy 2024, 18:2461-2474
Published Date: 20 June 2024