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Drug Design, Development and Therapy


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Novel 2-(5-Aryl-4,5-Dihydropyrazol-1-yl)thiazol-4-One as EGFR Inhibitors: Synthesis, Biological Assessment and Molecular Docking Insights

Al-Warhi T, El Kerdawy AM, Said MA, Albohy A, Elsayed ZM, Aljaeed N, Elkaeed EB, Eldehna WM, Abdel-Aziz HA, Abdelmoaz MA

Drug Design, Development and Therapy 2022, 16:1457-1471

Published Date: 16 May 2022

Silibinin Schiff Base Derivatives Counteract CCl4-Induced Acute Liver Injury by Enhancing Anti-Inflammatory and Antiapoptotic Bioactivities

Xu R, Qiu S, Zhang J, Liu X, Zhang L, Xing H, You M, Wang M, Lu Y, Zhang P, Zhu J

Drug Design, Development and Therapy 2022, 16:1441-1456

Published Date: 16 May 2022

Compatibility and Stability of Ten Commonly Used Clinical Drugs in Pediatric Electrolyte Supplements Injection

Shen H, Fu Y, Chen Y, Xia W, Jia ZJ, Yu Q, Zhang L, Han L

Drug Design, Development and Therapy 2022, 16:1433-1440

Published Date: 12 May 2022

Preparation, in vitro and in vivo Evaluation of Thermosensitive in situ Gel Loaded with Ibuprofen-Solid Lipid Nanoparticles for Rectal Delivery

Huang CH, Hu PY, Wu QY, Xia MY, Zhang WL, Lei ZQ, Li DX, Zhang GS, Feng JF

Drug Design, Development and Therapy 2022, 16:1407-1431

Published Date: 12 May 2022

Gancao Xiexin Decoction Ameliorates Ulcerative Colitis in Mice via Modulating Gut Microbiota and Metabolites

Luo YT, Wu J, Zhu FY, Wu JQ, Wu P, Liu YC

Drug Design, Development and Therapy 2022, 16:1383-1405

Published Date: 9 May 2022

Pharmacokinetics and Safety of Single and Multiple Doses of Peficitinib (ASP015K) in Healthy Chinese Subjects

Gao X, He X, Oshima H, Miyatake D, Otsuka Y, Kato K, Cai C, Wojtkowski T, Song N, Kaneko Y, Shi A

Drug Design, Development and Therapy 2022, 16:1365-1381

Published Date: 9 May 2022

Knee Osteoarthritis Therapy: Recent Advances in Intra-Articular Drug Delivery Systems

Ma L, Zheng X, Lin R, Sun AR, Song J, Ye Z, Liang D, Zhang M, Tian J, Zhou X, Cui L, Liu Y, Liu Y

Drug Design, Development and Therapy 2022, 16:1311-1347

Published Date: 4 May 2022

Novel Liposomal Rolipram Formulation for Clinical Application to Reduce Emesis

Gobejishvili L, Rodriguez WE, Bauer P, Wang Y, Soni C, Lydic T, Barve S, McClain C, Maldonado C

Drug Design, Development and Therapy 2022, 16:1301-1309

Published Date: 3 May 2022

Isoliquiritigenin Ameliorates Ischemia-Induced Myocardial Injury via Modulating the Nrf2/HO-1 Pathway in Mice

Yao D, Shi B, Wang S, Bao L, Tan M, Shen H, Zhang Z, Pan X, Yang Y, Wu Y, Gong K

Drug Design, Development and Therapy 2022, 16:1273-1287

Published Date: 29 April 2022

The Emerging Potential of Parthenolide Nanoformulations in Tumor Therapy

An T, Yin H, Lu Y, Liu F

Drug Design, Development and Therapy 2022, 16:1255-1272

Published Date: 29 April 2022

Integrated Network Pharmacology and Metabolomics Analysis to Reveal the Potential Mechanism of Siwu Paste on Aplastic Anemia Induced by Chemotherapy Drugs

He D, Dan W, Du Q, Shen BB, Chen L, Fang LZ, Kuang JJ, Tang CY, Cai P, Yu R, Zhang SH, Huang JH

Drug Design, Development and Therapy 2022, 16:1231-1254

Published Date: 28 April 2022

Intrathecal Injection of Ropivacaine Reduces Cervical Resistance in Late-Pregnant Rats

Hu Y, Fan LJ, Jiang YM, Liu H, Yong H, Peng C

Drug Design, Development and Therapy 2022, 16:1183-1189

Published Date: 26 April 2022

Effect of Systemic Lidocaine on Postoperative Early Recovery Quality in Patients Undergoing Supratentorial Tumor Resection

Zhao K, Dong Y, Su G, Wang Y, Ji T, Wu N, Cui X, Li W, Yang Y, Chen X

Drug Design, Development and Therapy 2022, 16:1171-1181

Published Date: 22 April 2022

Carvacrol Alleviates Hyperuricemia-Induced Oxidative Stress and Inflammation by Modulating the NLRP3/NF-κB Pathwayt

Riaz M, Al Kury LT, Atzaz N, Alattar A, Alshaman R, Shah FA, Li S

Drug Design, Development and Therapy 2022, 16:1159-1170

Published Date: 22 April 2022

Analagesic and Anti-Inflammatory Potentials of a Less Ulcerogenic Thiadiazinethione Derivative in Animal Models: Biochemical and Histochemical Correlates

Rahman K, Ali G, Khan R, Khan I, Ali I, Mosa OF, Ahmed A, Ayaz M, Nawaz A, Murthy HCA

Drug Design, Development and Therapy 2022, 16:1143-1157

Published Date: 21 April 2022

Dezocine Has the Potential to Regulate the Clinical and Biological Features of Tumors

Hu X, Luo B, Qiu L, Chen S, Wu Q, Chen Q, Liu X, Ling C, Deng S, Yuan M, Hu P

Drug Design, Development and Therapy 2022, 16:1121-1129

Published Date: 20 April 2022

Design, Synthesis, and Biological Evaluation of 2-Anilino-4-Triazolpyrimidine Derivatives as CDK4/HDACs Inhibitors

Wang S, Han S, Cheng W, Miao R, Li S, Tian X, Kan Q

Drug Design, Development and Therapy 2022, 16:1083-1097

Published Date: 11 April 2022

Progress on SARS-CoV-2 3CLpro Inhibitors: Inspiration from SARS-CoV 3CLpro Peptidomimetics and Small-Molecule Anti-Inflammatory Compounds

Zhu J, Zhang H, Lin Q, Lyu J, Lu Lu, Chen H, Zhang X, Zhang Y, Chen K

Drug Design, Development and Therapy 2022, 16:1067-1082

Published Date: 8 April 2022

Synergistic Effect of Combined Sub-Tenon Triamcinolone and Intravitreal Anti-VEGF Therapy for Uveitic Macular Edema

Lin D, Hu J, Wu K, Feng K, Zhao X, Lu Q, Ren M, Cao J, Liu R, Dai M, Nan K, Wang Y

Drug Design, Development and Therapy 2022, 16:1055-1066

Published Date: 8 April 2022

Therapeutic Potential of Janus Kinase Inhibitors for the Management of Interstitial Lung Disease

Huo R, Guo Q, Hu J, Li N, Gao R, Mi L, Zhang Z, Liu H, Guo Z, Zhao H, Zhang L, Xu K

Drug Design, Development and Therapy 2022, 16:991-998

Published Date: 2 April 2022

Involvement of Huanglian Jiedu Decoction on Microglia with Abnormal Sphingolipid Metabolism in Alzheimer’s Disease

Qi YY, Heng X, Yao ZY, Qu SY, Ge PY, Zhao X, Ni S, Guo R, Yang NY, Zhang QC, Zhu HX

Drug Design, Development and Therapy 2022, 16:931-950

Published Date: 30 March 2022

Molecular Mechanism Underlying Effects of Wumeiwan on Steroid-Dependent Asthma: A Network Pharmacology, Molecular Docking, and Experimental Verification Study

Lyu M, Wang Y, Chen Q, Qin J, Hou D, Huang S, Shao D, Gong X, Huang G, Zhang S, Zhang Z, Cui H

Drug Design, Development and Therapy 2022, 16:909-929

Published Date: 30 March 2022

Design, Synthesis and Biological Evaluation of 1,4-Benzenesulfonamide Derivatives as Glyoxalase I Inhibitors

Audat SA, Al-Balas QA, Al-Oudat BA, Athamneh MJ, Bryant-Friedrich A

Drug Design, Development and Therapy 2022, 16:873-885

Published Date: 28 March 2022

Clotrimazole Inhibits HCC Migration and Invasion by Modulating the ERK-p65 Signaling Pathway

Liu X, Gao J, Sun Y, Zhang F, Guo W, Zhang S

Drug Design, Development and Therapy 2022, 16:863-871

Published Date: 29 March 2022

Antidepressant-Like Effect and Mechanism of Ginsenoside Rd on Rodent Models of Depression

Li Y, Wang ML, Zhang B, Fan XX, Tang Q, Yu X, Li LN, Fan AR, Chang HS, Zhang LZ

Drug Design, Development and Therapy 2022, 16:843-861

Published Date: 28 March 2022

Use of Antivirals in SARS-CoV-2 Infection. Critical Review of the Role of Remdesivir

Moreno S, Alcázar B, Dueñas C, González del Castillo J, Olalla J, Antela A

Drug Design, Development and Therapy 2022, 16:827-841

Published Date: 25 March 2022

Co-Administration with Voriconazole Doubles the Exposure of Ruxolitinib in Patients with Hematological Malignancies

Zhao Y, Chen P, Dou L, Li F, Li M, Xu L, Chen J, Jia M, Huang S, Wang N, Luan S, Yang J, Bai N, Liu D

Drug Design, Development and Therapy 2022, 16:817-825

Published Date: 25 March 2022

cRGD Urokinase Liposomes for Thrombolysis in Rat Model of Acute Pulmonary Microthromboembolism

Liang C, Huang T, Zhang X, Rao H, Jin Z, Pan X, Li J, Mo Y, Cai Y, Wu J

Drug Design, Development and Therapy 2022, 16:801-816

Published Date: 25 March 2022

Yishen Qingli Heluo Granule in the Treatment of Chronic Kidney Disease: Network Pharmacology Analysis and Experimental Validation

Sun X, Huang Y, Zhu S, Yan J, Gan K, Xu Z, Wang S, Kang X, Zhang J, Sun W

Drug Design, Development and Therapy 2022, 16:769-787

Published Date: 24 March 2022

Clinical Characteristics and Risk Factors of Lung Injury Induced by Nab-Paclitaxel

Yoshioka K, Abe M, Shiko Y, Koshikawa K, Kawasaki Y, Iwasawa S, Terada J, Tsushima K, Tatsumi K, Suzuki T

Drug Design, Development and Therapy 2022, 16:759-767

Published Date: 22 March 2022

Comparing Efficacy of Different Analgesic Modalities in Patients Undergoing Total Knee Arthroplasty [Response To Letter]

Xiao R, Liu LF, Luo YR, Liu C, Jin XB, Zhou W, Xu GH

Drug Design, Development and Therapy 2022, 16:737-738

Published Date: 18 March 2022

A Systematic Review of the Global Intervention for SARS-CoV-2 Combating: From Drugs Repurposing to Molnupiravir Approval

Ashour NA, Abo Elmaaty A, Sarhan AA, Elkaeed EB, Moussa AM, Erfan IA, Al-Karmalawy AA

Drug Design, Development and Therapy 2022, 16:685-715

Published Date: 15 March 2022

The Astragaloside IV Derivative LS-102 Ameliorates Obesity-Related Nephropathy

Li Z, Yang W, Yang Y, Wu J, Luo P, Liu Y

Drug Design, Development and Therapy 2022, 16:647-664

Published Date: 14 March 2022

Platelet Rich Plasma and Its Use in Hair Regrowth: A Review

Paichitrojjana A, Paichitrojjana A

Drug Design, Development and Therapy 2022, 16:635-645

Published Date: 10 March 2022

Determination of the Dose-Response Relationship of Epidural Dexmedetomidine Combined with Ropivacaine for Labor Analgesia

Ni JX, Feng JL, Yao SJ, Ni LF, Song SB, Song CZ, Qian XW, Mei Z, Yu J

Drug Design, Development and Therapy 2022, 16:609-618

Published Date: 6 March 2022

New Series of VEGFR-2 Inhibitors and Apoptosis Enhancers: Design, Synthesis and Biological Evaluation

Abdallah AE, Mabrouk RR, Elnagar MR, Farrag AM, Kalaba MH, Sharaf MH, El-Fakharany EM, Bakhotmah DA, Elkaeed EB, Al Ward MMS

Drug Design, Development and Therapy 2022, 16:587-607

Published Date: 3 March 2022

Alleviating Aspirin-Induced Gastric Injury by Binding Aspirin to β-Lactoglobulin

Chen J, Gong M, Huang Z, Wang F, Wang Y, Hu Z, Zeng Z, Wang Y

Drug Design, Development and Therapy 2022, 16:571-586

Published Date: 1 March 2022

α-Mangostin Treats Early-Stage Adjuvant-Induced Arthritis of Rat by Regulating the CAP-SIRT1 Pathway in Macrophages

Chen WG, Zhang SS, Pan S, Wang ZF, Xu JY, Sheng XH, Yin Q, Wu YJ

Drug Design, Development and Therapy 2022, 16:509-520

Published Date: 27 February 2022

Safety, Pharmacokinetics and Pharmacodynamics of the Selective Glucocorticoid Receptor Modulator Velsecorat (AZD7594) Following Inhalation in Healthy Volunteers

Prothon S, Aurivillius M, Tehler U, Eriksson UG, Aggarwal A, Chen Y

Drug Design, Development and Therapy 2022, 16:485-497

Published Date: 23 February 2022

Noncanonical Wnt5a Signaling Suppresses Hippo/TAZ-Mediated Osteogenesis Partly Through the Canonical Wnt Pathway in SCAPs

Fu Y, Ma D, Fan F, Sun T, Han R, Yang Y, Zhang J

Drug Design, Development and Therapy 2022, 16:469-483

Published Date: 22 February 2022

Network Pharmacology and Molecular Docking Study of the Chinese Miao Medicine Sidaxue in the Treatment of Rheumatoid Arthritis

Wu N, Yuan T, Yin Z, Yuan X, Sun J, Wu Z, Zhang Q, Redshaw C, Yang S, Dai X

Drug Design, Development and Therapy 2022, 16:435-466

Published Date: 19 February 2022

Spray with Nitric Oxide Donor Accelerates Wound Healing: Potential Off-the-Shelf Solution for Therapy?

Igrunkova A, Fayzullin A, Churbanov S, Shevchenko P, Serejnikova N, Chepelova N, Pahomov D, Blinova E, Mikaelyan K, Zaborova V, Gurevich K, Urakov A, Vanin A, Timashev P, Shekhter A

Drug Design, Development and Therapy 2022, 16:349-362

Published Date: 16 February 2022

Emodin-Induced Autophagy Against Cell Apoptosis Through the PI3K/AKT/mTOR Pathway in Human Hepatocytes [Corrigendum]

Zheng X, Yang S, Zhang R, Wang S, Li G, Zhou S

Drug Design, Development and Therapy 2022, 16:345-347

Published Date: 16 February 2022

Uncovering the Potential Mechanisms of Coptis chinensis Franch. for Serious Mental Illness by Network Pharmacology and Pharmacology-Based Analysis

Qi Y, Ni S, Heng X, Qu S, Ge P, Zhao X, Yao Z, Guo R, Yang N, Zhang Q, Zhu H

Drug Design, Development and Therapy 2022, 16:325-342

Published Date: 9 February 2022

The Role of Progesterone Receptors in Breast Cancer

Li Z, Wei H, Li S, Wu P, Mao X

Drug Design, Development and Therapy 2022, 16:305-314

Published Date: 26 January 2022

Feasibility of Catalpol Intranasal Administration and Its Protective Effect on Acute Cerebral Ischemia in Rats via Anti-Oxidative and Anti-Apoptotic Mechanisms

Wang J, Zhang Y, Zhang M, Sun S, Zhong Y, Han L, Xu Y, Wan D, Zhang J, Zhu H

Drug Design, Development and Therapy 2022, 16:279-296

Published Date: 25 January 2022

Inhibition of JNK Phosphorylation by Curcumin Analog C66 Protects LPS-Induced Acute Lung Injury [Corrigendum]

Xiao Z, Xu F, Zhu X, Bai B, Guo L, Liang G, Shan X, Zhang Y, Zhao Y, Zhang B

Drug Design, Development and Therapy 2022, 16:249-250

Published Date: 19 January 2022

Advances in Engineered Three-Dimensional (3D) Body Articulation Unit Models

Chen Y, Wang Y, Luo SC, Zheng X, Kankala RK, Wang SB, Chen AZ

Drug Design, Development and Therapy 2022, 16:213-235

Published Date: 18 January 2022

Clinical Utility of Elosulfase Alfa in the Treatment of Morquio A Syndrome

Lee CL, Chuang CK, Chiu HC, Tu RY, Lo YT, Chang YH, Lin SP, Lin HY

Drug Design, Development and Therapy 2022, 16:143-154

Published Date: 10 January 2022

Berbamine Suppresses the Growth of Gastric Cancer Cells by Inactivating the BRD4/c-MYC Signaling Pathway

Li H, Luo K, Yang Z, Chen M, Yang X, Wang J, Ying Y, Wu D, Wang Q

Drug Design, Development and Therapy 2022, 16:129-141

Published Date: 11 January 2022

Intramuscular Corticosteroid Therapy in the Treatment of Alopecia Areata: A Time-to-Event Analysis

Chanprapaph K, Pomsoong C, Kositkuljorn C, Suchonwanit P

Drug Design, Development and Therapy 2022, 16:107-116

Published Date: 7 January 2022

Inhibition of CXCR4 in Spinal Cord and DRG with AMD3100 Attenuates Colon-Bladder Cross-Organ Sensitization

Zhang H, Dong X, Yang Z, Zhao J, Lu Q, Zhu J, Li L, Yi S, Xu J

Drug Design, Development and Therapy 2022, 16:67-81

Published Date: 6 January 2022

Promising Natural Products in New Drug Design, Development, and Therapy for Skin Disorders: An Overview of Scientific Evidence and Understanding Their Mechanism of Action

Mohd Zaid NA, Sekar M, Bonam SR, Gan SH, Lum PT, Begum MY, Mat Rani NNI, Vaijanathappa J, Wu YS, Subramaniyan V, Fuloria NK, Fuloria S

Drug Design, Development and Therapy 2022, 16:23-66

Published Date: 6 January 2022

Fatostatin in Combination with Tamoxifen Induces Synergistic Inhibition in ER-Positive Breast Cancer [Corrigendum]

Liu Y, Zhang N, Zhang H, Wang L, Duan Y, Wang X, Chen T, Liang Y, Li Y, Song X, Li C, Han D, Chen B, Zhao W, Yang Q

Drug Design, Development and Therapy 2022, 16:1-2

Published Date: 5 January 2022

Dynamics of Endocytosis and Degradation of Antibody-Drug Conjugate T-DM1 in HER2 Positive Cancer Cells

Liang K, Mei S, Gao X, Peng S, Zhan J

Drug Design, Development and Therapy 2021, 15:5135-5150

Published Date: 24 December 2021

Downregulation of IRF2 Alleviates Sepsis-Related Acute Kidney Injury in vitro and in vivo

Zhang Y, Zhang Y, Yang A, Xia F

Drug Design, Development and Therapy 2021, 15:5123-5132

Published Date: 22 December 2021

Establishment of Sunitinib-Resistant Xenograft Model of Renal Cell Carcinoma and the Identification of Drug-Resistant Hub Genes and Pathways

Xie Y, Shangguan W, Chen Z, Zheng Z, Chen Y, Zhong Q, Zhang Y, Yang J, Zhu D, Xie W

Drug Design, Development and Therapy 2021, 15:5061-5074

Published Date: 16 December 2021

Drug Repurposing: Deferasirox Inhibits the Anti-Apoptotic Activity of Mcl-1

Bourafai-Aziez A, Benabderrahmane M, Paysant H, Weiswald LB, Poulain L, Carlier L, Ravault D, Jouanne M, Coadou G, Oulyadi H, Voisin-Chiret AS, Sopková-de Oliveira Santos J, Sebban M

Drug Design, Development and Therapy 2021, 15:5035-5059

Published Date: 15 December 2021

(Rose Bengal)/(Eosin Yellow)-Gold-Polypyrrole Hybrids: A Design for Dual Photo-Active Nano-System with Ultra-High Loading Capacity

El-Kholy AI, Abdel Fadeel D, Nasr M, Fadel M, El-Sherbiny I

Drug Design, Development and Therapy 2021, 15:5011-5023

Published Date: 14 December 2021

Bio-Guided Isolation of Two New Hypoglycemic Triterpenoid Saponins from Polygonum capitatum

Huang D, Du Z, Chen Y, Dong Z, Wang X, Li M, Zhang F, Chen W, Sun L

Drug Design, Development and Therapy 2021, 15:5001-5010

Published Date: 14 December 2021

Cell-Penetrating Peptide-Modified Graphene Oxide Nanoparticles Loaded with Rictor siRNA for the Treatment of Triple-Negative Breast Cancer

Yang YY, Zhang W, Liu H, Jiang JJ, Wang WJ, Jia ZY

Drug Design, Development and Therapy 2021, 15:4961-4972

Published Date: 10 December 2021

Effects of Dezocine and Sufentanil on Th1/Th2 Balance in Breast Cancer Patients Undergoing Surgery

Hu X, Luo B, Wu Q, Chen Q, Lu P, Huang J, Liang X, Ling C, Li Y

Drug Design, Development and Therapy 2021, 15:4925-4938

Published Date: 2 December 2021

Network Pharmacology and Experimental Validation to Reveal the Pharmacological Mechanisms of Liuwei Dihuang Decoction Against Intervertebral Disc Degeneration

Zhang H, Yao S, Zhang Z, Zhou C, Fu F, Bian Y, Luo H, Li Y, Yan S, Ge Y, Chen Y, Zhan K, Ge Y, Chen Z, Yue M, Li X, Du W, Jin H, Tong P, Ruan H, Wu C

Drug Design, Development and Therapy 2021, 15:4911-4924

Published Date: 2 December 2021

Protective Effects of Mogroside V on Oxidative Stress Induced by H2O2 in Skin Fibroblasts

Mo Q, Fu H, Zhao D, Zhang J, Wang C, Wang D, Li M

Drug Design, Development and Therapy 2021, 15:4901-4909

Published Date: 1 December 2021

Ventilagolin Suppresses Migration, Invasion and Epithelial-Mesenchymal Transition of Hepatocellular Carcinoma Cells by Downregulating Pim-1

Liu Y, Cheng DH, Lai KD, Su H, Lu GS, Wang L, Lv JH

Drug Design, Development and Therapy 2021, 15:4885-4899

Published Date: 1 December 2021

Ruxolitinib for Treatment of Steroid-Refractory Graft-versus-Host Disease: Real-World Data from Chinese Patients

Wei C, Zhang X, Liang D, Yang J, Du J, Yue C, Deng L

Drug Design, Development and Therapy 2021, 15:4875-4883

Published Date: 30 November 2021

The Pharmacokinetic Effect of Itraconazole and Voriconazole on Ripretinib in Beagle Dogs by UPLC-MS/MS Technique

Wang H, Zhou C, Su Y, Gou K, Geng X, Qiu X

Drug Design, Development and Therapy 2021, 15:4865-4873

Published Date: 30 November 2021

Methylcobalamin Protects Melanocytes from H2O2-Induced Oxidative Stress by Activating the Nrf2/HO-1 Pathway

An R, Li D, Dong Y, She Q, Zhou T, Nie X, Pan R, Deng Y

Drug Design, Development and Therapy 2021, 15:4837-4848

Published Date: 30 November 2021

UPLC–MS/MS and Network Pharmacology-Based Analysis of Bioactive Anti-Depression Compounds in Betel Nut

Yang Y, Huang H, Cui Z, Chu J, Du G

Drug Design, Development and Therapy 2021, 15:4827-4836

Published Date: 30 November 2021

Oroxin B Attenuates Ovariectomy-Induced Bone Loss by Suppressing Osteoclast Formation and Activity

Huang JM, Wang CZ, Lu SY, Wang Z, Yan ZQ

Drug Design, Development and Therapy 2021, 15:4811-4825

Published Date: 30 November 2021

Berberine Influences the Survival of Fat Grafting by Inhibiting Autophagy and Apoptosis of Human Adipose Derived Mesenchymal Stem Cells

Pang H, Zhou Y, Wang J, Wu H, Liu X, Gao F, Xiao Z

Drug Design, Development and Therapy 2021, 15:4795-4809

Published Date: 30 November 2021

Toxicological Evaluation of a Probiotic-Based Delivery System for P8 Protein as an Anti-Colorectal Cancer Drug

An BC, Yoon YS, Park HJ, Park S, Kim TY, Ahn JY, Kwon D, Choi O, Heo JY, Ryu Y, Kim JH, Eom H, Chung MJ

Drug Design, Development and Therapy 2021, 15:4761-4793

Published Date: 27 November 2021

Hearing Protection Outcomes of Analog Electrode Arrays Coated with Different Drug-Eluting Polymer Films Implanted into Guinea Pig Cochleae [Corrigendum]

Huang Y, Yu H, Liang M, Hou S, Chen JM, Zhang F, Sun X, Jia H, Yang J

Drug Design, Development and Therapy 2021, 15:4759-4760

Published Date: 24 November 2021

Inhibition of Lipopolysaccharide-Induced Inflammatory Bone Loss by Saikosaponin D is Associated with Regulation of the RANKL/RANK Pathway

Wu X, Zhao K, Fang X, Lu F, Zhang W, Song X, Chen L, Sun J, Chen H

Drug Design, Development and Therapy 2021, 15:4741-4757

Published Date: 23 November 2021

Clinical Effect of Doxycycline Combined with Compound Sulfamethoxazole and Rifampicin in the Treatment of Brucellosis Spondylitis

Yang XM, Jia YL, Zhang Y, Zhang PN, Yao Y, Yin YL, Tian Y

Drug Design, Development and Therapy 2021, 15:4733-4740

Published Date: 23 November 2021

Therapeutic Effects and Safe Uses of Plant-Derived Polyphenolic Compounds in Cardiovascular Diseases: A Review

Alotaibi BS, Ijaz M, Buabeid M, Kharaba ZJ, Yaseen HS, Murtaza G

Drug Design, Development and Therapy 2021, 15:4713-4732

Published Date: 20 November 2021

Activation of GPR18 by Resolvin D2 Relieves Pain and Improves Bladder Function in Cyclophosphamide-Induced Cystitis Through Inhibiting TRPV1

Lu Q, Yang Y, Zhang H, Chen C, Zhao J, Yang Z, Fan Y, Li L, Feng H, Zhu J, Yi S

Drug Design, Development and Therapy 2021, 15:4687-4699

Published Date: 15 November 2021

A Retrospective Cohort Study Evaluates Clinical Value of Anlotinib in Persistent, Metastatic, or Recurrent Cervical Cancer After Failure of First-Line Therapy

Yang H, Sun S, Mei Z, Xiang Q, Yang C, Chen M, Xie C, Zhou Y, Qiu H

Drug Design, Development and Therapy 2021, 15:4665-4674

Published Date: 16 November 2021

Transdermal Delivery of Telmisartan: Formulation, in vitro, ex vivo, Iontophoretic Permeation Enhancement and Comparative Pharmacokinetic Study in Rats

Teaima M, Abdelmonem R, Adel YA, El-Nabarawi MA, El-Nawawy TM

Drug Design, Development and Therapy 2021, 15:4603-4614

Published Date: 10 November 2021

Prunella vulgaris L. Attenuates Experimental Autoimmune Thyroiditis by Inhibiting HMGB1/TLR9 Signaling

Guo Q, Qu H, Zhang H, Zhong X

Drug Design, Development and Therapy 2021, 15:4559-4574

Published Date: 4 November 2021

Chemistry, Biosynthesis, Physicochemical and Biological Properties of Rubiadin: A Promising Natural Anthraquinone for New Drug Discovery and Development

Watroly MN, Sekar M, Fuloria S, Gan SH, Jeyabalan S, Wu YS, Subramaniyan V, Sathasivam KV, Ravi S, Mat Rani NNI, Lum PT, Vaijanathappa J, Meenakshi DU, Mani S, Fuloria NK

Drug Design, Development and Therapy 2021, 15:4527-4549

Published Date: 3 November 2021

Anti-Inflammatory Effects of Curcumin in the Inflammatory Diseases: Status, Limitations and Countermeasures

Peng Y, Ao M, Dong B, Jiang Y, Yu L, Chen Z, Hu C, Xu R

Drug Design, Development and Therapy 2021, 15:4503-4525

Published Date: 2 November 2021

Artemisinin Improves Acetylcholine-Induced Vasodilatation in Rats with Primary Hypertension

Liu X, Wang X, Pan Y, Zhao L, Sun S, Luo A, Bao C, Tang H, Han Y

Drug Design, Development and Therapy 2021, 15:4489-4502

Published Date: 2 November 2021

Enhancement of Cancer Chemotherapeutic Efficacy via Bone-Targeted Drug Delivery Carrier in Bone Metastases

Xue X, Yu J, Lu F, Jiang H, Wang X

Drug Design, Development and Therapy 2021, 15:4455-4468

Published Date: 28 October 2021

An Overview on the Potential Roles of EGCG in the Treatment of COVID-19 Infection

Bimonte S, Forte CA, Cuomo M, Esposito G, Cascella M, Cuomo A

Drug Design, Development and Therapy 2021, 15:4447-4454

Published Date: 28 October 2021

The Effects of Primary Unconjugated Bile Acids on Nanoencapsulated Pharmaceutical Formulation of Hydrophilic Drugs: Pharmacological Implications

Mooranian A, Foster T, Ionescu CM, Carey L, Walker D, Jones M, Wagle SR, Kovacevic B, Chester J, Johnstone E, Kuthubutheen J, Brown D, Atlas MD, Mikov M, Al-Salami H

Drug Design, Development and Therapy 2021, 15:4423-4434

Published Date: 23 October 2021

Mechanism of Yinqin Oral Liquid in the Treatment of Chronic Pharyngitis Based on Network Pharmacology

Ji S, Xu F, Zhu R, Wang C, Guo D, Jiang Y

Drug Design, Development and Therapy 2021, 15:4413-4421

Published Date: 20 October 2021

Unravelling the Protective Effects of Emodin Against Cyclophosphamide Induced Gonadotoxicity in Male Wistar Rats

Wang Y, Zou Z, Jaisi A, Olatunji OJ

Drug Design, Development and Therapy 2021, 15:4403-4411

Published Date: 19 October 2021

The Steady-State Comparative Bioavailability of Intramuscular Risperidone ISM and Oral Risperidone: An Open-Label, One-Sequence Study

Walling DP, Hassman HA, Anta L, Ochoa L, Ayani I, Martínez J, Gutierro I

Drug Design, Development and Therapy 2021, 15:4371-4382

Published Date: 15 October 2021

Translational Regulation in Hepatocellular Carcinogenesis

Bracic Tomazic S, Schatz C, Haybaeck J

Drug Design, Development and Therapy 2021, 15:4359-4369

Published Date: 14 October 2021

The Expanding Role of Pyridine and Dihydropyridine Scaffolds in Drug Design

Ling Y, Hao ZY, Liang D, Zhang CL, Liu YF, Wang Y

Drug Design, Development and Therapy 2021, 15:4289-4338

Published Date: 13 October 2021

Triptolide is a Promising Therapeutic Approach in Treating Thyroid Cancer Based on in silico and in vitro Experiment

Wang F, An SJ, Yin Y, Li JJ, Sun CH, Lan J, Zhao WJ, Li CQ

Drug Design, Development and Therapy 2021, 15:4275-4287

Published Date: 11 October 2021

The Therapeutic Effects of Curcumin in Early Septic Acute Kidney Injury: An Experimental Study

Wang S, Zhao P, Zhang Y, Zhu L, Zhu J, Luo Y, Li Q

Drug Design, Development and Therapy 2021, 15:4243-4255

Published Date: 7 October 2021

Saroglitazar – A Potential Therapeutic Option in Treating NASH? [Letter]

Shuja SH, Eqbal F, Rehman H

Drug Design, Development and Therapy 2021, 15:4227-4228

Published Date: 8 October 2021

Development and Characterization of Ulvan Polysaccharides-Based Hydrogel Films for Potential Wound Dressing Applications

Sulastri E, Zubair MS, Lesmana R, Mohammed AFA, Wathoni N

Drug Design, Development and Therapy 2021, 15:4213-4226

Published Date: 5 October 2021

Novel Anti-Tubulin Compounds from Trigonella foenum-graecum Seeds; Insights into In-vitro and Molecular Docking Studies

Alghamdi SS, Suliman RS, Alsaeed AS, Almutairi KK, Aljammaz NA, Altolayyan A, Ali R, Alhallaj A

Drug Design, Development and Therapy 2021, 15:4195-4211

Published Date: 5 October 2021

Synthesis of Novel Pinocembrin Amino Acid Derivatives and Their Antiaging Effect on Caenorhabditis elegans via the Modulating DAF-16/FOXO

Wang W, Feng X, Du Y, Liu C, Pang X, Jiang K, Wang X, Liu Y

Drug Design, Development and Therapy 2021, 15:4177-4193

Published Date: 5 October 2021

Development of an UPLC-MS/MS Method for the Quantitative Analysis of Upadacitinib in Beagle Dog Plasma and Pharmacokinetics Study

Wang MJ, Zhao YH, Fan C, Wang YJ, Wang XQ, Qiu XJ, Shen RL

Drug Design, Development and Therapy 2021, 15:4167-4175

Published Date: 2 October 2021

The Role of Pretreatment 18F-FDG PET/CT for Early Prediction of Neoadjuvant Chemotherapy Response in Patients with Locoregionally Advanced Nasopharyngeal Carcinoma

Yao J, Wang Y, Lin Y, Yang Y, Wan J, Gong X, Zhang F, Zhang W, Marks T, Wang S, Jin H, Shan H

Drug Design, Development and Therapy 2021, 15:4157-4166

Published Date: 1 October 2021

Transcriptome-Based Analysis Reveals Therapeutic Effects of Resveratrol on Endometriosis in aRat Model

Wang C, Chen Z, Zhao X, Lin C, Hong S, Lou Y, Shi X, Zhao M, Yang X, Guan MX, Xi Y

Drug Design, Development and Therapy 2021, 15:4141-4155

Published Date: 29 September 2021

Orally Deliverable Dual-Targeted Pellets for the Synergistic Treatment of Ulcerative Colitis

Tang X, Yang M, Gu Y, Jiang L, Du Y, Liu J

Drug Design, Development and Therapy 2021, 15:4105-4123

Published Date: 29 September 2021

Topical Lidocaine for Chronic Pain Treatment

Voute M, Morel V, Pickering G

Drug Design, Development and Therapy 2021, 15:4091-4103

Published Date: 29 September 2021

Evolution of Drug Delivery Systems for Recurrent Aphthous Stomatitis

Suharyani I, Fouad Abdelwahab Mohammed A, Muchtaridi M, Wathoni N, Abdassah M

Drug Design, Development and Therapy 2021, 15:4071-4089

Published Date: 27 September 2021

Synergistic Dose Permutation of Isolated Alkaloid and Sterol for Anticancer Effect on Young Swiss Albino Mice

Aljarba NH, Ali H, Alkahtani S

Drug Design, Development and Therapy 2021, 15:4043-4052

Published Date: 23 September 2021

Antioxidant, Anti-Aging and Organ Protective Effects of Total Saponins from Aralia taibaiensis

Li H, Zhai B, Sun J, Fan Y, Zou J, Cheng J, Zhang X, Shi Y, Guo D

Drug Design, Development and Therapy 2021, 15:4025-4042

Published Date: 23 September 2021

A Network Pharmacology Study on the Molecular Mechanism of Protocatechualdehyde in the Treatment of Diabetic Cataract

Cheng X, Song Z, Wang X, Xu S, Dong L, Bai J, Li G, Zhang C

Drug Design, Development and Therapy 2021, 15:4011-4023

Published Date: 23 September 2021

Non-Alcoholic Steatohepatitis (NASH) – A Review of a Crowded Clinical Landscape, Driven by a Complex Disease

Fraile JM, Palliyil S, Barelle C, Porter AJ, Kovaleva M

Drug Design, Development and Therapy 2021, 15:3997-4009

Published Date: 22 September 2021

Selection of DNA Aptamers Recognizing EpCAM-Positive Prostate Cancer by Cell-SELEX for in vitro and in vivo MR Imaging

Zhong J, Ding J, Deng L, Xiang Y, Liu D, Zhang Y, Chen X, Yang Q

Drug Design, Development and Therapy 2021, 15:3985-3996

Published Date: 21 September 2021

Stability of Amoxicillin and Clavulanic Acid in Separate Containers for Administration via a Y-Site

Fawaz S, Merzouk M, Barton S, Nabhani-Gebara S

Drug Design, Development and Therapy 2021, 15:3979-3984

Published Date: 21 September 2021

Ketamine Induces Ferroptosis of Liver Cancer Cells by Targeting lncRNA PVT1/miR-214-3p/GPX4

He GN, Bao NR, Wang S, Xi M, Zhang TH, Chen FS

Drug Design, Development and Therapy 2021, 15:3965-3978

Published Date: 18 September 2021

LC–MS/MS Estimation of Rociletinib Levels in Human Liver Microsomes: Application to Metabolic Stability Estimation

Attwa MW, Abdelhameed AS, Kadi AA

Drug Design, Development and Therapy 2021, 15:3915-3925

Published Date: 15 September 2021

The Anticancer Potential of Maslinic Acid and Its Derivatives: A Review

Yu L, Xie X, Cao X, Chen J, Chen G, Chen Y, Li G, Qin J, Peng F, Peng C

Drug Design, Development and Therapy 2021, 15:3863-3879

Published Date: 9 September 2021

In vitro Comparison of Pancreatic Enzyme Preparations Available in the Indian Market

Shrikhande SV, Prasad VGM, Domínguez-Muñoz JE, Weigl KE, Sarda KD

Drug Design, Development and Therapy 2021, 15:3835-3843

Published Date: 7 September 2021

Integrating Network Pharmacology and Experimental Verification to Explore the Mechanism of Effect of Zuojin Pills in Pancreatic Cancer Treatment

Wang K, Miao X, Kong F, Huang S, Mo J, Jin C, Zheng Y

Drug Design, Development and Therapy 2021, 15:3749-3764

Published Date: 4 September 2021

The Legislative Approach and System Improvement of China’s Compulsory Licensing for Drug Patents

Cao Z, Chen Y, Jiang W, Li W

Drug Design, Development and Therapy 2021, 15:3717-3731

Published Date: 1 September 2021

Retrospective Study of the Effects of Zoledronic Acid on Muscle Mass in Osteoporosis Patients

Huang CF, Shiao MS, Mao TY

Drug Design, Development and Therapy 2021, 15:3711-3715

Published Date: 27 August 2021

Puerarin Alleviates UUO-Induced Inflammation and Fibrosis by Regulating the NF-κB P65/STAT3 and TGFβ1/Smads Signaling Pathways

Wang J, Ge S, Wang Y, Liu Y, Qiu L, Li J, Huang X, Sun L

Drug Design, Development and Therapy 2021, 15:3697-3708

Published Date: 24 August 2021

Effects of Avitinib on CYP450 Enzyme Activity in vitro and in vivo in Rats

Shi Y, Meng D, Wang S, Geng P, Xu T, Zhou Q, Zhou Y, Li W, Chen X

Drug Design, Development and Therapy 2021, 15:3661-3673

Published Date: 21 August 2021

Icariin, an Up-and-Coming Bioactive Compound Against Neurological Diseases: Network Pharmacology-Based Study and Literature Review

Wang S, Ma J, Zeng Y, Zhou G, Wang Y, Zhou W, Sun X, Wu M

Drug Design, Development and Therapy 2021, 15:3619-3641

Published Date: 20 August 2021

Bi-aryl Analogues of Salicylic Acids: Design, Synthesis and SAR Study to Ameliorate Endoplasmic Reticulum Stress

Kim YE, Kim DH, Choi A, Jang S, Jeong K, Kim YM, Nam TG

Drug Design, Development and Therapy 2021, 15:3593-3604

Published Date: 17 August 2021

Gene Therapy for Rdh12-Associated Retinal Diseases Helps to Delay Retinal Degeneration and Vision Loss

Bian J, Chen H, Sun J, Cao Y, An J, Pan Q, Qi M

Drug Design, Development and Therapy 2021, 15:3581-3591

Published Date: 17 August 2021

The Clinical Efficacy of Three Different Follicle-Stimulating Hormones for Follicle Growth and Development in Long-Protocol Controlled Ovarian Hyperstimulation Treatment

Zhang XQ, Zhang LJ, Zhu XL, Xu H, Luo YQ, Yao L, Huang QW, Nong YQ, Liu WJ, Liu FH

Drug Design, Development and Therapy 2021, 15:3573-3580

Published Date: 16 August 2021

Prompt Agalsidase Alfa Therapy Initiation is Associated with Improved Renal and Cardiovascular Outcomes in a Fabry Outcome Survey Analysis

Hughes D, Linhart A, Gurevich A, Kalampoki V, Jazukeviciene D, Feriozzi S

Drug Design, Development and Therapy 2021, 15:3561-3572

Published Date: 16 August 2021

The Synergistic Effect of Ginkgo biloba Extract 50 and Aspirin Against Platelet Aggregation

Ke J, Li MT, Huo YJ, Cheng YQ, Guo SF, Wu Y, Zhang L, Ma J, Liu AJ, Han Y

Drug Design, Development and Therapy 2021, 15:3543-3560

Published Date: 14 August 2021

Effectiveness and Anticancer Activity of a Novel Phenolic Compound from Garcinia porrecta Against the MCF-7 Breast Cancer Cell Line in vitro and in silico

Darwati D, Safitri AN, Ambardhani N, Mayanti T, Nurlelasari N, Kurnia D

Drug Design, Development and Therapy 2021, 15:3523-3533

Published Date: 12 August 2021

Quercetin Prevents Oxidative Stress-Induced Injury of Periodontal Ligament Cells and Alveolar Bone Loss in Periodontitis

Wei Y, Fu J, Wu W, Ma P, Ren L, Yi Z, Wu J

Drug Design, Development and Therapy 2021, 15:3509-3522

Published Date: 12 August 2021

The Reproductive Toxicity of Monosodium Glutamate by Damaging GnRH Neurons Cannot Be Relieved Spontaneously Over Time

Wang CX, Zhang Y, Li QF, Sun HL, Chong HL, Jiang JX, Li QC

Drug Design, Development and Therapy 2021, 15:3499-3508

Published Date: 12 August 2021

Establishment of Prognostic Nomograms for Predicting the Survival of HR-Positive, HER2-Negative Metastatic Breast Cancer Patients Treated with Everolimus

Duan F, Song C, Ma Y, Jiang K, Xu F, Bi X, Huang J, Hong R, Huang Z, Lu Q, Yuan Z, Wang S, Xia W

Drug Design, Development and Therapy 2021, 15:3463-3473

Published Date: 10 August 2021

Ecust004 Suppresses Breast Cancer Cell Growth, Invasion, and Migration via EMT Regulation

Liu Z, Huang L, Sun L, Nie H, Liang Y, Huang J, Wu F, Hu X

Drug Design, Development and Therapy 2021, 15:3451-3461

Published Date: 10 August 2021

Hearing Protection Outcomes of Analog Electrode Arrays Coated with Different Drug-Eluting Polymer Films Implanted into Guinea Pig Cochleae

Huang Y, Yu H, Liang M, Hou S, Chen JM, Zhang F, Sun X, Jia H, Yang J

Drug Design, Development and Therapy 2021, 15:3443-3450

Published Date: 11 August 2021

Network Pharmacology and Experimental Evidence: PI3K/AKT Signaling Pathway is Involved in the Antidepressive Roles of Chaihu Shugan San

Zhang S, Lu Y, Chen W, Shi W, Zhao Q, Zhao J, Li L

Drug Design, Development and Therapy 2021, 15:3425-3441

Published Date: 5 August 2021

What to Do About Missed Doses? A Retrospective Study of Olanzapine in the Elderly

Xiao T, Wang Z, Li G, Huang S, Zhu X, Liu S, Li X, Hu J, Shang D, Wen Y

Drug Design, Development and Therapy 2021, 15:3411-3423

Published Date: 4 August 2021

Evidence and Current Use of Levosimendan in the Treatment of Heart Failure: Filling the Gap

Conti N, Gatti M, Raschi E, Diemberger I, Potena L

Drug Design, Development and Therapy 2021, 15:3391-3409

Published Date: 4 August 2021

COVID-19: Vaccine Delivery System, Drug Repurposing and Application of Molecular Modeling Approach

Abd El Hadi SR, Zien El-Deen EE, Bahaa MM, Sadakah AA, Yassin HA

Drug Design, Development and Therapy 2021, 15:3313-3330

Published Date: 30 July 2021

Imidazole as a Promising Medicinal Scaffold: Current Status and Future Direction

Alghamdi SS, Suliman RS, Almutairi K, Kahtani K, Aljatli D

Drug Design, Development and Therapy 2021, 15:3289-3312

Published Date: 29 July 2021

Effect of Berberine on Hyperuricemia and Kidney Injury: A Network Pharmacology Analysis and Experimental Validation in a Mouse Model

Li Q, Huang Z, Liu D, Zheng J, Xie J, Chen J, Zeng H, Su Z, Li Y

Drug Design, Development and Therapy 2021, 15:3241-3254

Published Date: 27 July 2021

Baicalin Alleviates Oxidative Stress and Inflammation in Diabetic Nephropathy via Nrf2 and MAPK Signaling Pathway

Ma L, Wu F, Shao Q, Chen G, Xu L, Lu F

Drug Design, Development and Therapy 2021, 15:3207-3221

Published Date: 21 July 2021

A Network Pharmacology-Based Investigation to the Pharmacodynamic Material Basis and Mechanisms of the Anti-Inflammatory and Anti-Viral Effect of Isatis indigotica

Deng J, Ma Y, He Y, Yang H, Chen Y, Wang L, Huang D, Qiu S, Tao X, Chen W

Drug Design, Development and Therapy 2021, 15:3193-3206

Published Date: 20 July 2021

Analysis of Clinical Trials of New Drugs for Liver Diseases in China

Lin L, Li H

Drug Design, Development and Therapy 2021, 15:3181-3191

Published Date: 20 July 2021

Baicalin Rescues Cognitive Dysfunction, Mitigates Neurodegeneration, and Exerts Anti-Epileptic Effects Through Activating TLR4/MYD88/Caspase-3 Pathway in Rats

Yang J, Jia Z, Xiao Z, Zhao J, Lu Y, Chu L, Shao H, Pei L, Zhang S, Chen Y

Drug Design, Development and Therapy 2021, 15:3163-3180

Published Date: 20 July 2021

Evaluation of Natural Bioactive-Derived Punicalagin Niosomes in Skin-Aging Processes Accelerated by Oxidant and Ultraviolet Radiation

Mohamad EA, Aly AA, Khalaf AA, Ahmed MI, Kamel RM, Abdelnaby SM, Abdelzaher YH, Sedrak MG, Mousa SA

Drug Design, Development and Therapy 2021, 15:3151-3162

Published Date: 17 July 2021

Wogonin Alleviates Kidney Tubular Epithelial Injury in Diabetic Nephropathy by Inhibiting PI3K/Akt/NF-κB Signaling Pathways

Lei L, Zhao J, Liu XQ, Chen J, Qi XM, Xia LL, Wu YG

Drug Design, Development and Therapy 2021, 15:3131-3150

Published Date: 16 July 2021

Design, Synthesis, Characterization and in vivo Antidiabetic Activity Evaluation of Some Chalcone Derivatives

Welday Kahssay S, Hailu GS, Taye Desta K

Drug Design, Development and Therapy 2021, 15:3119-3129

Published Date: 17 July 2021

The Potential Use of Ceftazidime-Avibactam Against Carbapenem Resistant Klebsiella pneumoniae Clinical Isolates Harboring Different Carbapenemase Types in a Thai University Hospital

Nasomsong W, Nulsopapon P, Changpradub D, Pongchaidecha M, Pungcharoenkijkul S, Juntanawiwat P, Simsiriporn W, Santimaleeworagun W

Drug Design, Development and Therapy 2021, 15:3095-3104

Published Date: 16 July 2021

In vitro Antimicrobial Activity of Fosfomycin, Rifampin, Vancomycin, Daptomycin Alone and in Combination Against Vancomycin-Resistant Enterococci

Tong J, Jiang Y, Xu H, Jin X, Zhang L, Ying S, Yu W, Qiu Y

Drug Design, Development and Therapy 2021, 15:3049-3055

Published Date: 12 July 2021

A Call to Action by the Italian Mesotherapy Society on Scientific Research

Mammucari M, Paolucci T, Russo D, Maggiori E, Di Marzo R, Migliore A, Massafra U, Ronconi G, Ferrara PE, Gori F, Bifarini B, Brauneis S, Vellucci R, Mediati RD, Violo B, Natoli S, Pediliggieri C, Di Campli C, Collina MC

Drug Design, Development and Therapy 2021, 15:3041-3047

Published Date: 12 July 2021

Effects of Exenatide on Coagulation and Platelet Aggregation in Patients with Type 2 Diabetes

Zhang Y, Chen R, Jia Y, Chen M, Shuai Z

Drug Design, Development and Therapy 2021, 15:3027-3040

Published Date: 12 July 2021

Review of Allopregnanolone Agonist Therapy for the Treatment of Depressive Disorders

Walkery A, Leader LD, Cooke E, VandenBerg A

Drug Design, Development and Therapy 2021, 15:3017-3026

Published Date: 9 July 2021

Total Flavone of Abelmoschus manihot Ameliorates Stress-Induced Microbial Alterations Drive Intestinal Barrier Injury in DSS Colitis

Wang R, Chen T, Wang Q, Yuan XM, Duan ZL, Feng ZY, Ding Y, Bu F, Shi GP, Chen YG

Drug Design, Development and Therapy 2021, 15:2999-3016

Published Date: 8 July 2021

Assessing Palatability of a New Amphetamine Extended-Release Tablet Formulation for the Treatment of ADHD

Pardo A, King TR, Rafla E, Kando JC

Drug Design, Development and Therapy 2021, 15:2979-2985

Published Date: 8 July 2021

Spotlight on Melphalan Flufenamide: An Up-and-Coming Therapy for the Treatment of Myeloma

Morabito F, Tripepi G, Martino EA, Vigna E, Mendicino F, Morabito L, Todoerti K, Al-Janazreh H, D’Arrigo G, Canale FA, Cutrona G, Neri A, Martino M, Gentile M

Drug Design, Development and Therapy 2021, 15:2969-2978

Published Date: 8 July 2021

Pharmacokinetic Study of Frovatriptan Succinate Tablet After Single and Multiple Oral Doses in Chinese Healthy Subjects

Zheng H, Xia Y, Qu S, Fan L, Zhang J, Ma Z, Chen Y, Fan H

Drug Design, Development and Therapy 2021, 15:2961-2968

Published Date: 7 July 2021

A Phase I Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of TPN171H, a Novel Phosphodiesterase Type 5 Inhibitor, in Healthy Subjects

Qian H, Chen Q, Liang L, Zou Y, Pu H, Xin L, Song R, Li T, Zhu H, Wang Y, Tian G, Shen J, Jiang H, Yu C, Wang Z, Jia J

Drug Design, Development and Therapy 2021, 15:2947-2959

Published Date: 6 July 2021

Mechanism of Tetrandrine Against Endometrial Cancer Based on Network Pharmacology

Shang W, Zhang J, Song H, Zhu S, Zhang A, Hua Y, Han S, Fu Y

Drug Design, Development and Therapy 2021, 15:2907-2919

Published Date: 6 July 2021

Evaluation of Ceftazidime/Avibactam Administration in Enterobacteriaceae and Pseudomonas aeruginosa Bloodstream Infections by Monte Carlo Simulation

Dai Y, Chang W, Zhou X, Yu W, Huang C, Chen Y, Ma X, Lu H, Ji R, Ying C, Wang P, Liu Z, Yuan Q, Xiao Y

Drug Design, Development and Therapy 2021, 15:2899-2905

Published Date: 6 July 2021

A Novel Folic Acid Receptor-Targeted Drug Delivery System Based on Curcumin-Loaded β-Cyclodextrin Nanoparticles for Cancer Treatment

Hong W, Guo F, Yu N, Ying S, Lou B, Wu J, Gao Y, Ji X, Wang H, Li A, Wang G, Yang G

Drug Design, Development and Therapy 2021, 15:2843-2855

Published Date: 30 June 2021

Profiling Pretomanid as a Therapeutic Option for TB Infection: Evidence to Date

Stancil SL, Mirzayev F, Abdel-Rahman SM

Drug Design, Development and Therapy 2021, 15:2815-2830

Published Date: 28 June 2021

Study on the Inhibitory Effect of Curcumin on GBM and Its Potential Mechanism

Su X, Chen S, Lu H, Li H, Qin C

Drug Design, Development and Therapy 2021, 15:2769-2781

Published Date: 28 June 2021

Progress in Redirecting Antiparasitic Drugs for Cancer Treatment

Huang H, He Q, Guo B, Xu X, Wu Y, Li X

Drug Design, Development and Therapy 2021, 15:2747-2767

Published Date: 22 June 2021

Chemistry, Pharmacology and Therapeutic Potential of Swertiamarin – A Promising Natural Lead for New Drug Discovery and Development

Muhamad Fadzil NS, Sekar M, Gan SH, Bonam SR, Wu YS, Vaijanathappa J, Ravi S, Lum PT, Dhadde SB

Drug Design, Development and Therapy 2021, 15:2721-2746

Published Date: 21 June 2021

Prospective Application of Two New Pyridine-Based Zinc (II) Amide Carboxylate in Management of Alzheimer’s Disease: Synthesis, Characterization, Computational and in vitro Approaches

Zafar R, Naureen H, Zubair M, Shahid K, Saeed Jan M, Akhtar S, Ahmad H, Waseem W, Haider A, Ali S, Tariq M, Sadiq A

Drug Design, Development and Therapy 2021, 15:2679-2694

Published Date: 21 June 2021

Immunoregulatory Effect of Acanthopanax trifoliatus (L.) Merr. Polysaccharide on T1DM Mice

Li P, Chen Y, Luo L, Yang H, Pan Y

Drug Design, Development and Therapy 2021, 15:2629-2639

Published Date: 18 June 2021

Effect of a 2-HP-β-Cyclodextrin Formulation on the Biological Transport and Delivery of Chemotherapeutic PLGA Nanoparticles

Zheng K, Huang Z, Huang J, Liu X, Ban J, Huang X, Luo H, Chen Z, Xie Q, Chen Y, Lu Z

Drug Design, Development and Therapy 2021, 15:2605-2618

Published Date: 17 June 2021

Synthesis, Radiolabeling, and Preliminary in vivo Evaluation of [68Ga] IPCAT-NOTA as an Imaging Agent for Dopamine Transporter

Farn SS, Chang KW, Lin WC, Yu HM, Lin KL, Tseng YC, Chang Y, Yu CS, Lin WJ

Drug Design, Development and Therapy 2021, 15:2577-2591

Published Date: 17 June 2021

Estrogen and Preeclampsia: Potential of Estrogens as Therapeutic Agents in Preeclampsia

Shu C, Han S, Xu P, Wang Y, Cheng T, Hu C

Drug Design, Development and Therapy 2021, 15:2543-2550

Published Date: 15 June 2021

The Current Evidence for the Use of Safinamide for the Treatment of Parkinson’s Disease

Abbruzzese G, Barone P, Lopiano L, Stocchi F

Drug Design, Development and Therapy 2021, 15:2507-2517

Published Date: 10 June 2021

Inhibitors Targeting YAP in Gastric Cancer: Current Status and Future Perspectives

Yong J, Li Y, Lin S, Wang Z, Xu Y

Drug Design, Development and Therapy 2021, 15:2445-2456

Published Date: 9 June 2021

High-Dose Dexmedetomidine Promotes Apoptosis in Fetal Rat Hippocampal Neurons

Wei Q, Chen J, Xiao F, Tu Y, Zhong Y, Xie Y

Drug Design, Development and Therapy 2021, 15:2433-2444

Published Date: 8 June 2021

Tetramethylpyrazine Improves Cognitive Function of Alzheimer’s Disease Mice by Regulating SSTR4 Ubiquitination

Weng G, Zhou B, Liu T, Huang Z, Huang S

Drug Design, Development and Therapy 2021, 15:2385-2399

Published Date: 1 June 2021

Pharmacokinetics, Tolerability and Pharmacogenetics of DA-8031 After Multiple Ascending Doses in Healthy Male Subjects

Hwang S, Lee DY, Cho JY, Chung JY, Jang IJ, Yu KS, Lee S

Drug Design, Development and Therapy 2021, 15:2375-2384

Published Date: 1 June 2021

Topical Delivery of Levocarnitine to the Cornea and Anterior Eye by Thermosensitive in-situ Gel for Dry Eye Disease

Ma B, Pang L, Huang P, Bai J, Zhang Z, Wu H, Cai M, Yang J, Xu Y, Yin X, Qu C, Ni J

Drug Design, Development and Therapy 2021, 15:2357-2373

Published Date: 2 June 2021

Cinnamaldehyde Improves Metabolic Functions in Streptozotocin-Induced Diabetic Mice by Regulating Gut Microbiota

Zhao H, Wu H, Duan M, Liu R, Zhu Q, Zhang K, Wang L

Drug Design, Development and Therapy 2021, 15:2339-2355

Published Date: 1 June 2021

Novel Phenolic Compounds as Potential Dual EGFR and COX-2 Inhibitors: Design, Semisynthesis, in vitro Biological Evaluation and in silico Insights

Abdelgawad MA, Musa A, Almalki AH, Alzarea SI, Mostafa EM, Hegazy MM, Mostafa-Hedeab G, Ghoneim MM, Parambi DGT, Bakr RB, Al-Muaikel NS, Alanazi AS, Alharbi M, Ahmad W, Bukhari SNA, Al-Sanea MM

Drug Design, Development and Therapy 2021, 15:2325-2337

Published Date: 31 May 2021

Selective Inhibition of 11β-Hydroxysteroid Dehydrogenase Type 1 Attenuates High-Fat Diet-Induced Hepatic Steatosis in Mice

Li H, Sheng J, Wang J, Gao H, Yu J, Ding G, Ding N, He W, Zha J

Drug Design, Development and Therapy 2021, 15:2309-2324

Published Date: 31 May 2021

Incidence and Risk Factors of Hepatic Fibrosis in Psoriatic Patients Receiving Methotrexate with Concomitant Acitretin Therapy and Methotrexate Monotherapy

Rattanakaemakorn P, Pinyowiwat P, Iamsumang W, Chanprapaph K, Suchonwanit P

Drug Design, Development and Therapy 2021, 15:2299-2307

Published Date: 28 May 2021

Clinical Application of Cytokines in Cancer Immunotherapy

Qiu Y, Su M, Liu L, Tang Y, Pan Y, Sun J

Drug Design, Development and Therapy 2021, 15:2269-2287

Published Date: 27 May 2021

A Review of Romiplostim Mechanism of Action and Clinical Applicability

Bussel JB, Soff G, Balduzzi A, Cooper N, Lawrence T, Semple JW

Drug Design, Development and Therapy 2021, 15:2243-2268

Published Date: 26 May 2021

Enhanced Accumulation of Cisplatin in Ovarian Cancer Cells from Combination with Wedelolactone and Resulting Inhibition of Multiple Epigenetic Drivers

Sarwar S, Alamro AA, Alghamdi AA, Naeem K, Ullah S, Arif M, Yu JQ, Huq F

Drug Design, Development and Therapy 2021, 15:2211-2227

Published Date: 25 May 2021

Fixed Dose Single Tablet Formulation with Differential Release of Amlodipine Besylate and Simvastatin and Its Pharmacokinetic Profile: QbD and Risk Assessment Approach

Kanwal U, Mukhtar S, Waheed M, Mehreen A, Abbas N, Shamim R, Hussain K, Rasool F, Hussain A, Bukhari NI

Drug Design, Development and Therapy 2021, 15:2193-2210

Published Date: 24 May 2021

Development of UPLC-MS/MS Method for Studying the Pharmacokinetic Interaction Between Dasatinib and Posaconazole in Rats

Yang S, Zhang X, Wang Y, Wen C, Wang C, Zhou Z, Lin G

Drug Design, Development and Therapy 2021, 15:2171-2178

Published Date: 24 May 2021

Effect of Dexmedetomidine on Postoperative Sleep Quality: A Systematic Review

Huang X, Lin D, Sun Y, Wu A, Wei C

Drug Design, Development and Therapy 2021, 15:2161-2170

Published Date: 21 May 2021

Toxicities and Associated Factors in Patients Receiving Temozolomide-Containing Regimens: A 12-Year Analysis of Hospital Data

Shi C, Wang X, Diao C, Zhu H, Yuan Q, Liu J, Li S, Gu M, Zhang Y

Drug Design, Development and Therapy 2021, 15:2151-2159

Published Date: 20 May 2021

Pharmacokinetics of Linezolid Dose Adjustment for Creatinine Clearance in Critically Ill Patients: A Multicenter, Prospective, Open-Label, Observational Study

Wang X, Wang Y, Yao F, Chen S, Hou Y, Zheng Z, Luo J, Qiu B, Li Z, Wang Y, Wu Z, Lan J, Chen C

Drug Design, Development and Therapy 2021, 15:2129-2141

Published Date: 19 May 2021

Canagliflozin Facilitates Reverse Cholesterol Transport Through Activation of AMPK/ABC Transporter Pathway

Zhao Y, Li Y, Liu Q, Tang Q, Zhang Z, Zhang J, Huang C, Huang H, Zhang G, Zhou J, Yan J, Xia Y, Zhang Z, He J

Drug Design, Development and Therapy 2021, 15:2117-2128

Published Date: 18 May 2021

Antifungal Efficacy and Safety of Cycloheximide as a Supplement in Optisol-GS

Dal Pizzol M, Freitas EC, Locatelli C, Guareze F, Reginatto P, Machado G, Fuentefria A, Marinho D

Drug Design, Development and Therapy 2021, 15:2091-2098

Published Date: 18 May 2021

Protective Effect of Lemon Peel Extract on Oxidative Stress in H9c2 Rat Heart Cell Injury

Wang J, Zhai Y, Ou M, Bian Y, Tang C, Zhang W, Cheng Y, Li G

Drug Design, Development and Therapy 2021, 15:2047-2058

Published Date: 14 May 2021

Silver Nanoparticle-Coated Ethyl Cellulose Inhibits Tumor Necrosis Factor-α of Breast Cancer Cells

Abdellatif AAH, Alsharidah M, Al Rugaie O, Tawfeek HM, Tolba NS

Drug Design, Development and Therapy 2021, 15:2035-2046

Published Date: 13 May 2021

PTBP1 Targets ILK to Regulate the Hypoxia-Induced Phenotypic Transformation of Pulmonary Artery Smooth Muscle Cells

Yan G, Sun R, Chen Z, Pan X, Sheng Z, Tang C

Drug Design, Development and Therapy 2021, 15:2025-2033

Published Date: 13 May 2021

FTY720 Inhibits the Development of Collagen-Induced Arthritis in Mice by Suppressing the Recruitment of CD4+ T Lymphocytes

Zhu C, Wen S, Li J, Meng H, Zhang J, Zhao K, Wang L, Zhang Y

Drug Design, Development and Therapy 2021, 15:1981-1992

Published Date: 11 May 2021

Bempedoic Acid for Heterozygous Familial Hypercholesterolemia: From Bench to Bedside

Agarwala A, Quispe R, Goldberg AC, Michos ED

Drug Design, Development and Therapy 2021, 15:1955-1963

Published Date: 10 May 2021

Consolidation Treatment and Long-Term Prognosis of Rituximab in Minimal Change Disease and Focal Segmental Glomerular Sclerosis

Lin L, Wang W, Wu Y, Xie J, Li X, Pan X, Zhang W, Xu J, Cai Y, Ren H, Chen N

Drug Design, Development and Therapy 2021, 15:1945-1953

Published Date: 10 May 2021

Potential Mechanism of S. baicalensis on Lipid Metabolism Explored via Network Pharmacology and Untargeted Lipidomics

Ge PY, Qi YY, Qu SY, Zhao X, Ni S, Yao ZY, Guo R, Yang NY, Zhang QC, Zhu HX

Drug Design, Development and Therapy 2021, 15:1915-1930

Published Date: 4 May 2021

Protective Effects of Silymarin Against D-Gal/LPS-Induced Organ Damage and Inflammation in Mice

Zhao X, Wang H, Yang Y, Gou Y, Wang Z, Yang D, Li C

Drug Design, Development and Therapy 2021, 15:1903-1914

Published Date: 4 May 2021

Study on Hepatotoxicity of Rhubarb Based on Metabolomics and Network Pharmacology

Li S, Wang Y, Li C, Yang N, Yu H, Zhou W, Chen S, Yang S, Li Y

Drug Design, Development and Therapy 2021, 15:1883-1902

Published Date: 4 May 2021

Camrelizumab Combined with FOLFOX4 Regimen as First-Line Therapy for Advanced Hepatocellular Carcinomas: A Sub-Cohort of a Multicenter Phase Ib/II Study

Li H, Qin S, Liu Y, Chen Z, Ren Z, Xiong J, Meng Z, Zhang X, Wang L, Zhang X, Zou J

Drug Design, Development and Therapy 2021, 15:1873-1882

Published Date: 3 May 2021

Exosomal Circ-XIAP Promotes Docetaxel Resistance in Prostate Cancer by Regulating miR-1182/TPD52 Axis

Zhang H, Li M, Zhang J, Shen Y, Gui Q

Drug Design, Development and Therapy 2021, 15:1835-1849

Published Date: 3 May 2021

OSU-03012 Disrupts Akt Signaling and Prevents Endometrial Carcinoma Progression in vitro and in vivo

Ding L, Ren C, Yang L, Wu Z, Li F, Jiang D, Zhu Y, Lu J

Drug Design, Development and Therapy 2021, 15:1797-1810

Published Date: 30 April 2021

Integrating Network Pharmacology and Experimental Validation to Decipher the Mechanism of Action of Huanglian Jiedu Decoction in Treating Atherosclerosis

Liang J, Huang Y, Mai Z, Zhan Q, Lin H, Xie Y, Wang H, Liu Y, Luo C

Drug Design, Development and Therapy 2021, 15:1779-1795

Published Date: 30 April 2021

Alendronate Alleviated Femoral Head Necrosis and Upregulated BMP2/EIF2AK3/EIF2A/ATF4 Pathway in Liquid Nitrogen Treated Rats

Rong K, Li X, Jiang W, Wu X, Xia Q, Chen J, Yin X

Drug Design, Development and Therapy 2021, 15:1717-1724

Published Date: 23 April 2021

Rituximab Therapy for Treatment of Pemphigus in Southeast Asians

Kanokrungsee S, Anuntrangsee T, Tankunakorn J, Srisuwanwattana P, Suchonwanit P, Chanprapaph K

Drug Design, Development and Therapy 2021, 15:1677-1690

Published Date: 22 April 2021

Lactobacillus plantarum ZS62 Alleviates Alcohol-Induced Gastric Injury in Mice via an Anti-Oxidative Mechanism

Wu Y, Hu J, Long X, Pan Y, Mu J, Park KY, Zhao X

Drug Design, Development and Therapy 2021, 15:1667-1676

Published Date: 22 April 2021

Temozolomide-Induced Changes in Gut Microbial Composition in a Mouse Model of Brain Glioma

Li XC, Wu BS, Jiang Y, Li J, Wang ZF, Ma C, Li YR, Yao J, Jin XQ, Li ZQ

Drug Design, Development and Therapy 2021, 15:1641-1652

Published Date: 21 April 2021

Population Pharmacokinetics and Safety of Oral Tetra-Arsenic Tetra-Sulfide Formula in Pediatric Acute Promyelocytic Leukemia

Zhang L, Yang XM, Chen J, Hu L, Yang F, Zhou Y, Zhao BB, Zhao W, Zhu XF

Drug Design, Development and Therapy 2021, 15:1633-1640

Published Date: 21 April 2021

In vitro Preparation and Evaluation of Sustained-Release Microcapsules of Salvianolic Acid

Wang YH, Qu T, Wang XL, Yang RP

Drug Design, Development and Therapy 2021, 15:1623-1631

Published Date: 21 April 2021

Pharmacological Management of Gastro-Esophageal Reflux Disease: An Update of the State-of-the-Art

Savarino V, Marabotto E, Zentilin P, Demarzo MG, de Bortoli N, Savarino E

Drug Design, Development and Therapy 2021, 15:1609-1621

Published Date: 19 April 2021

An Ensemble Model for Prediction of Vancomycin Trough Concentrations in Pediatric Patients

Huang X, Yu Z, Bu S, Lin Z, Hao X, He W, Yu P, Wang Z, Gao F, Zhang J, Chen J

Drug Design, Development and Therapy 2021, 15:1549-1559

Published Date: 14 April 2021

Preparation Optimization of Bovine Serum Albumin Nanoparticles and Its Application for siRNA Delivery

Wang Y, Chen S, Yang X, Zhang S, Cui C

Drug Design, Development and Therapy 2021, 15:1531-1547

Published Date: 14 April 2021

Solasodine, Isolated from Solanum sisymbriifolium Fruits, Has a Potent Anti-Tumor Activity Against Pancreatic Cancer

Fan Y, Li Z, Wu L, Lin F, Shao J, Ma X, Yao Y, Zhuang W, Wang Y

Drug Design, Development and Therapy 2021, 15:1509-1519

Published Date: 13 April 2021

Pharmaceutical Development of 5-Fluorouracil-Eluting Stents for the Potential Treatment of Gastrointestinal Cancers and Related Obstructions

Arafat M, Song Y, Brewer K, Fouladian P, Parikh A, Albrecht H, Blencowe A, Garg S

Drug Design, Development and Therapy 2021, 15:1495-1507

Published Date: 9 April 2021

Low-Dose Triple Antihypertensive Combination Therapy in Patients with Hypertension: A Randomized, Double-Blind, Phase II Study [Corrigendum]

Hong SJ, Sung KC, Lim SW, Kim SY, Kim W, Shin J, Park S, Kim HY, Rhee MY

Drug Design, Development and Therapy 2021, 15:1477-1478

Published Date: 7 April 2021

Amino Acid Conjugates of Aminothiazole and Aminopyridine as Potential Anticancer Agents: Synthesis, Molecular Docking and in vitro Evaluation

Naz S, Shah FA, Nadeem H, sarwar S, Tan Z, Imran M, Ali T, Li JB, Li S

Drug Design, Development and Therapy 2021, 15:1459-1476

Published Date: 1 April 2021

White Tip Silver Needle (Slightly Fermented White Tea) Flavonoids Help Prevent Aging via Antioxidative and Anti-Inflammatory Effects

Li C, He J, Yang Y, Gou Y, Wang Z, Chen H, Zhao X

Drug Design, Development and Therapy 2021, 15:1441-1457

Published Date: 31 March 2021

The Risks of miRNA Therapeutics: In a Drug Target Perspective [Erratum]

Zhang S, Cheng Z, Wang Y, Han T

Drug Design, Development and Therapy 2021, 15:1423-1424

Published Date: 30 March 2021

Edaravone Alleviated Propofol-Induced Neurotoxicity in Developing Hippocampus by mBDNF/TrkB/PI3K Pathway

Yang Y, Yi J, Pan M, Hu B, Duan H

Drug Design, Development and Therapy 2021, 15:1409-1422

Published Date: 30 March 2021

Caspase Cascade Activation During Apoptotic Cell Death of Human Lung Carcinoma Cells A549 Induced by Marine Sponge Callyspongia aerizusa

Hadisaputri YE, Andika R, Sopyan I, Zuhrotun A, Maharani R, Rachmat R, Abdulah R

Drug Design, Development and Therapy 2021, 15:1357-1368

Published Date: 29 March 2021

Inhibitory Effects of Periplocin on Lymphoma Cells: A Network Pharmacology Approach and Experimental Validation

Zhao R, Han C, Dai S, Wei S, Xiang X, Wang Y, Zhao R, Zhao L, Shan B

Drug Design, Development and Therapy 2021, 15:1333-1344

Published Date: 26 March 2021

Nα-1, 3-Benzenedicarbonyl-Bis-(Amino Acid) and Dipeptide Candidates: Synthesis, Cytotoxic, Antimicrobial and Molecular Docking Investigation

Naglah AM, Moustafa GO, Elhenawy AA, Mounier MM, El-Sayed H, Al-Omar MA, Almehizia AA, Bhat MA

Drug Design, Development and Therapy 2021, 15:1315-1332

Published Date: 25 March 2021

Synthesis of Michael Adducts as Key Building Blocks for Potential Analgesic Drugs: In vitro, in vivo and in silico Explorations

Ahmad S, Mahnashi MH, Alyami BA, Alqahtani YS, Ullah F, Ayaz M, Tariq M, Sadiq A, Rashid U

Drug Design, Development and Therapy 2021, 15:1299-1313

Published Date: 23 March 2021

Application of Topical Immunotherapy in the Treatment of Alopecia Areata: A Review and Update

Mahasaksiri T, Kositkuljorn C, Anuntrangsee T, Suchonwanit P

Drug Design, Development and Therapy 2021, 15:1285-1298

Published Date: 23 March 2021

Role of p38 Mitogen-Activated Protein Kinase in Asthma and COPD: Pathogenic Aspects and Potential Targeted Therapies

Pelaia C, Vatrella A, Gallelli L, Lombardo N, Sciacqua A, Savino R, Pelaia G

Drug Design, Development and Therapy 2021, 15:1275-1284

Published Date: 23 March 2021

Study on the Mechanism of Jiawei Shengjiang Powder in Improving Male Asthma-Induced Asthenospermia Based on Network Pharmacology and Bioinformatics

Wang JS, Gong XF, Feng JL, Li HS, Li X, Deng S, Ren PZ, Wang JM, Lv MS, Jin RF, Chen QY, Wang B, Cui HS

Drug Design, Development and Therapy 2021, 15:1245-1259

Published Date: 19 March 2021

Drug Discovery and Development in Rare Diseases: Taking a Closer Look at the Tafamidis Story

Burton A, Castaño A, Bruno M, Riley S, Schumacher J, Sultan MB, See Tai S, Judge DP, Patel JK, Kelly JW

Drug Design, Development and Therapy 2021, 15:1225-1243

Published Date: 18 March 2021

Potential Anti-Coronavirus Agents and the Pharmacologic Mechanisms

Yang Y, Cui X, Wei H, Guo C, Zhang Y

Drug Design, Development and Therapy 2021, 15:1213-1223

Published Date: 17 March 2021

Repeated Doses of Ketamine Affect the Infant Rat Urogenital System

Kasıkara H, Sungu N, Arslan M, Kucuk A, Ozturk L, Afandiyeva N, Kavutcu M

Drug Design, Development and Therapy 2021, 15:1157-1165

Published Date: 11 March 2021

Antibacterial and Antimicrobial Effects of Xanthorrhizol in the Prevention of Dental Caries: A Systematic Review

Khalid GS, Hamrah MH, Ghafary ES, Hosseini S, Almasi F

Drug Design, Development and Therapy 2021, 15:1149-1156

Published Date: 11 March 2021

The Efficacy and Safety of Abrocitinib as a Treatment Option for Atopic Dermatitis: A Short Report of the Clinical Data

Napolitano M, Fabbrocini G, Ruggiero A, Marino V, Nocerino M, Patruno C

Drug Design, Development and Therapy 2021, 15:1135-1147

Published Date: 10 March 2021

Withanone from Withania somnifera Attenuates SARS-CoV-2 RBD and Host ACE2 Interactions to Rescue Spike Protein Induced Pathologies in Humanized Zebrafish Model

Balkrishna A, Pokhrel S, Singh H, Joshi M, Mulay VP, Haldar S, Varshney A

Drug Design, Development and Therapy 2021, 15:1111-1133

Published Date: 11 March 2021

Safety, Tolerability and Pharmacokinetics of Single and Multiple Ascending Doses of Benfotiamine in Healthy Subjects

Sheng L, Cao W, Lin P, Chen W, Xu H, Zhong C, Yuan F, Chen H, Li H, Liu C, Yang M, Li X

Drug Design, Development and Therapy 2021, 15:1101-1110

Published Date: 9 March 2021

Investigation of the Active Ingredients and Mechanism of Polygonum cuspidatum in Asthma Based on Network Pharmacology and Experimental Verification

Bi J, Lin YH, Sun Y, Zhang M, Chen Q, Miu X, Tang L, Liu J, Zhu L, Ni Z, Wang X

Drug Design, Development and Therapy 2021, 15:1075-1089

Published Date: 9 March 2021

An Overview of Bimekizumab for the Treatment of Psoriatic Arthritis: The Evidence so Far

G Oliveira D, Faria R, Torres T

Drug Design, Development and Therapy 2021, 15:1045-1053

Published Date: 9 March 2021

Role of Oxidative Stress and Reduced Endogenous Hydrogen Sulfide in Diabetic Nephropathy

Hussain Lodhi A, Ahmad FUD, Furwa K, Madni A

Drug Design, Development and Therapy 2021, 15:1031-1043

Published Date: 5 March 2021

Epigallocatechin-3-Gallate Promotes the in vitro Maturation and Embryo Development Following IVF of Porcine Oocytes

Huang K, Li C, Gao F, Fan Y, Zeng F, Meng L, Li L, Zhang S, Wei H

Drug Design, Development and Therapy 2021, 15:1013-1020

Published Date: 4 March 2021

The Effect of Nintedanib on T-Cell Activation, Subsets and Functions

Ubieta K, Thomas MJ, Wollin L

Drug Design, Development and Therapy 2021, 15:997-1011

Published Date: 8 March 2021

Dihydroartemisinin Inhibits TGF-β-Induced Fibrosis in Human Tenon Fibroblasts via Inducing Autophagy

Wang X, Song W, Zhang F, Huang R

Drug Design, Development and Therapy 2021, 15:973-981

Published Date: 3 March 2021

Characterization of Oxygenated Heterocyclic Compounds and in vitro Antioxidant Activity of Pomelo Essential Oil

Li G, Cheng Y, Zhang T, Li Y, Han L, Liang G

Drug Design, Development and Therapy 2021, 15:937-947

Published Date: 2 March 2021

Lidocaine Inhibits Myoblast Cell Migration and Myogenic Differentiation Through Activation of the Notch Pathway

Ling X, Ma X, Kuang X, Zou Y, Zhang H, Tang H, Du H, Zhu B, Huang H, Xia Q, Chen M, Mao D, Chen D, Shen H, Yan J

Drug Design, Development and Therapy 2021, 15:927-936

Published Date: 2 March 2021

Bitter Taste Receptor as a Therapeutic Target in Orthopaedic Disorders

Cheng W, Yao M, Liu F

Drug Design, Development and Therapy 2021, 15:895-903

Published Date: 26 February 2021

Low Frequency of Integrase Inhibitor Resistance Mutations Among Therapy-Naïve HIV Patients in Southeast China

Lai J, Liu Y, Han X, Huang A, Lin J, Ao W, Ye H, Chen Y

Drug Design, Development and Therapy 2021, 15:889-894

Published Date: 26 February 2021

Effects of Sugammadex versus Neostigmine on Intraoperative Coagulation Profiles in Patients with Thyroidectomy

Zhao D, Fang J, Xiong W, Lin J, Chen W, Wu C

Drug Design, Development and Therapy 2021, 15:829-834

Published Date: 25 February 2021

Efficacy and Safety of Retinol Palmitate Ophthalmic Solution in the Treatment of Dry Eye: A Japanese Phase II Clinical Trial [Corrigendum]

Toshida H, Funaki T, Ono K, Tabuchi N, Watanabe S, Seki T, Otake H, Kato T, Ebihara N, Murakami A

Drug Design, Development and Therapy 2021, 15:813-816

Published Date: 24 February 2021

Convallatoxin Promotes M2 Macrophage Polarization to Attenuate Atherosclerosis Through PPARγ-Integrin αvβ5 Signaling Pathway

Zhang Y, Shi X, Han J, Peng W, Fang Z, Zhou Y, Xu X, Lin J, Xiao F, Zhao L, Lin Y

Drug Design, Development and Therapy 2021, 15:803-812

Published Date: 23 February 2021

Mechanism of Action of Xiaoyao San in Treatment of Ischemic Stroke is Related to Anti-Apoptosis and Activation of PI3K/Akt Pathway

Xu Y, Chen W, Chen Z, Huang M, Yang F, Zhang Y

Drug Design, Development and Therapy 2021, 15:753-767

Published Date: 22 February 2021

The Effectiveness of Ruxolitinib for Acute/Chronic Graft-versus-Host Disease in Children: A Retrospective Study

Yang W, Zhu G, Qin M, Li Z, Wang B, Yang J, Wang T

Drug Design, Development and Therapy 2021, 15:743-752

Published Date: 22 February 2021

Addition of Celebrex and Pregabalin to Ropivacaine for Posterior Spinal Surgery: A Randomized, Double-Blinded, Placebo-Controlled Trial

Zhang Y, He B, Zhao J, Zhang M, Ren Q, Zhang W, Xu S, Quan Z, Ou Y

Drug Design, Development and Therapy 2021, 15:735-742

Published Date: 22 February 2021

The Risks of miRNA Therapeutics: In a Drug Target Perspective

Zhang S, Cheng Z, Wang Y, Han T

Drug Design, Development and Therapy 2021, 15:721-733

Published Date: 22 February 2021

Danggui Buxue Decoction in the Treatment of Metastatic Colon Cancer: Network Pharmacology Analysis and Experimental Validation

Feng SH, Zhao B, Zhan X, Motanyane R, Wang SM, Li A

Drug Design, Development and Therapy 2021, 15:705-720

Published Date: 24 February 2021

Glucocorticoid-Like Activity of Escin: A New Mechanism for an Old Drug

Gallelli L, Cione E, Wang T, Zhang L

Drug Design, Development and Therapy 2021, 15:699-704

Published Date: 24 February 2021

Trans-Cinnamaldehyde Increases Random Pattern Flap Survival Through Activation of the Nitric Oxide Pathway

Luo X, Zhao B, Chen B, Chen H, Han T, Bsoul NBN, Yan H

Drug Design, Development and Therapy 2021, 15:679-688

Published Date: 18 February 2021

Thiazole-Based Thiosemicarbazones: Synthesis, Cytotoxicity Evaluation and Molecular Docking Study

Gomha SM, Abdelhady HA, Hassain DZH, Abdelmonsef AH, El-Naggar M, Elaasser MM, Mahmoud HK

Drug Design, Development and Therapy 2021, 15:659-677

Published Date: 17 February 2021

Progress in Clinical Research on Gonadotropin-Releasing Hormone Receptor Antagonists for the Treatment of Prostate Cancer

Liu YF, Fu SQ, Yan YC, Gong BB, Xie WJ, Yang XR, Sun T, Ma M

Drug Design, Development and Therapy 2021, 15:639-649

Published Date: 16 February 2021

Effect of Different Dosage Frequency of Polymyxin B on Rat Nephrotoxicity

Sun W, Hu B, Zhang X, Wang Y, Xiang Z, Lin G

Drug Design, Development and Therapy 2021, 15:611-616

Published Date: 16 February 2021

Effects of Quercetin on the Efficacy of Various Chemotherapeutic Drugs in Cervical Cancer Cells

Xu W, Xie S, Chen X, Pan S, Qian H, Zhu X

Drug Design, Development and Therapy 2021, 15:577-588

Published Date: 15 February 2021

Self-Nanoemulsifying Drug Delivery System of Genkwanin: A Novel Approach for Anti-Colitis-Associated Colorectal Cancer

Yin HF, Yin CM, Ouyang T, Sun SD, Chen WG, Yang XL, He X, Zhang CF

Drug Design, Development and Therapy 2021, 15:557-576

Published Date: 12 February 2021

Magnesium Isoglycyrrhizinate Alleviates Arsenic Trioxide-Induced Cardiotoxicity: Contribution of Nrf2 and TLR4/NF-κB Signaling Pathway

Zheng B, Yang Y, Li J, Li J, Zuo S, Chu X, Xu S, Ma D, Chu L

Drug Design, Development and Therapy 2021, 15:543-556

Published Date: 12 February 2021

Synergistic Anticancer Strategy of Sonodynamic Therapy Combined with PI-103 Against Hepatocellular Carcinoma

Yang H, Jing H, Han X, Tan H, Cheng W

Drug Design, Development and Therapy 2021, 15:531-542

Published Date: 11 February 2021

L-Cysteine Provides Neuroprotection of Hypoxia-Ischemia Injury in Neonatal Mice via a PI3K/Akt-Dependent Mechanism

Li T, Li J, Li T, Zhao Y, Ke H, Wang S, Liu D, Wang Z

Drug Design, Development and Therapy 2021, 15:517-529

Published Date: 11 February 2021

Loganin Attenuates Septic Acute Renal Injury with the Participation of AKT and Nrf2/HO-1 Signaling Pathways

Zhang J, Wang C, Kang K, Liu H, Liu X, Jia X, Yu K

Drug Design, Development and Therapy 2021, 15:501-513

Published Date: 11 February 2021

EGCG Regulates Cell Apoptosis of Human Umbilical Vein Endothelial Cells Grown on 316L Stainless Steel for Stent Implantation

Wang J, Wang Y, Zhao Y, Zhao J, Zhang B, Xu K

Drug Design, Development and Therapy 2021, 15:493-499

Published Date: 11 February 2021

Profile of Enfortumab Vedotin in the Treatment of Urothelial Carcinoma: The Evidence to Date

Moussa M, Papatsoris A, Abou Chakra M, Dellis A

Drug Design, Development and Therapy 2021, 15:453-462

Published Date: 11 February 2021

Effect of Evodiamine on Rat Colonic Hypermotility Induced by Water Avoidance Stress and the Underlying Mechanism

Ren H, Yuan F, Tan W, Ding Y, An P, Luo H

Drug Design, Development and Therapy 2021, 15:441-452

Published Date: 10 February 2021

Design, Synthesis, Molecular Modelling, and Biological Evaluation of Oleanolic Acid-Arylidene Derivatives as Potential Anti-Inflammatory Agents

Hassan Mir R, Godavari G, Siddiqui NA, Ahmad B, Mothana RA, Ullah R, Almarfadi OM, Jachak SM, Masoodi MH

Drug Design, Development and Therapy 2021, 15:385-397

Published Date: 4 February 2021

Thiazolidine Derivatives Attenuate Carrageenan-Induced Inflammatory Pain in Mice

Malik Z, Abbas M, Al Kury LT, Shah FA, Alam M, Khan AU, Nadeem H, Alghamdi S, Sahibzada MUK, Li S

Drug Design, Development and Therapy 2021, 15:369-384

Published Date: 4 February 2021

Irisin Protects Against Hind Limb Ischemia Reperfusion Injury

Küçük A, Polat Y, Kılıçarslan A, Süngü N, Kartal H, Dursun AD, Arslan M

Drug Design, Development and Therapy 2021, 15:361-368

Published Date: 4 February 2021

New Approach in Ocular Drug Delivery: In vitro and ex vivo Investigation of Cyclodextrin-Containing, Mucoadhesive Eye Drop Formulations

Bíró T, Bocsik A, Jurišić Dukovski B, Gróf I, Lovrić J, Csóka I, Deli MA, Aigner Z

Drug Design, Development and Therapy 2021, 15:351-360

Published Date: 3 February 2021

CircNRIP1 Modulates the miR-515-5p/IL-25 Axis to Control 5-Fu and Cisplatin Resistance in Nasopharyngeal Carcinoma

Lin J, Qin H, Han Y, Li X, Zhao Y, Zhai G

Drug Design, Development and Therapy 2021, 15:323-330

Published Date: 27 January 2021

Phenotyping Study of Cyclophosphamide 4-Hydroxylation in Malay Cancer Patients

Fityatal Hasanah YI, Harahap Y, Purwanto DJ

Drug Design, Development and Therapy 2021, 15:305-313

Published Date: 26 January 2021

Physcion Protects Rats Against Cerebral Ischemia-Reperfusion Injury via Inhibition of TLR4/NF-kB Signaling Pathway

Dong X, Wang L, Song G, Cai X, Wang W, Chen J, Wang G

Drug Design, Development and Therapy 2021, 15:277-287

Published Date: 25 January 2021

Effects of Caffeic Acid and Its Derivatives on Bone: A Systematic Review

Ekeuku SO, Pang KL, Chin KY

Drug Design, Development and Therapy 2021, 15:259-275

Published Date: 22 January 2021

Paeoniflorin Sensitizes Breast Cancer Cells to Tamoxifen by Downregulating microRNA-15b via the FOXO1/CCND1/β-Catenin Axis

Wang Y, Wang Q, Li X, Luo G, Shen M, Shi J, Wang X, Tang L

Drug Design, Development and Therapy 2021, 15:245-257

Published Date: 22 January 2021

Gracillin Isolated from Reineckia carnea Induces Apoptosis of A549 Cells via the Mitochondrial Pathway

Yang J, Cao L, Li Y, Liu H, Zhang M, Ma H, Wang B, Yuan X, Liu Q

Drug Design, Development and Therapy 2021, 15:233-243

Published Date: 20 January 2021

Galangin Improved Non-Alcoholic Fatty Liver Disease in Mice by Promoting Autophagy [Corrigendum]

Zhang X, Deng Y, Xiang J, Liu H, Zhang J, Liao J, Chen K, Liu B, Liu J, Pu Y

Drug Design, Development and Therapy 2021, 15:231-232

Published Date: 20 January 2021

Clinical Significance of Continuable Treatment with Nintedanib Over 12 Months for Idiopathic Pulmonary Fibrosis in a Real-World Setting

Kato M, Sasaki S, Tateyama M, Arai Y, Motomura H, Sumiyoshi I, Ochi Y, Watanabe J, Ihara H, Togo S, Takahashi K

Drug Design, Development and Therapy 2021, 15:223-230

Published Date: 18 January 2021

H2O2-Inactivated Salmonella typhimurium RE88 Strain as a New Cancer Vaccine Carrier: Evaluation in a Mouse Model of Cancer

Fan Y, Bai T, Tian Y, Zhou B, Wang Y, Yang L

Drug Design, Development and Therapy 2021, 15:209-222

Published Date: 15 January 2021

Quaternary Lidocaine Derivatives: Past, Present, and Future

Wang Q, Zhang Y, Liu J, Zhang W

Drug Design, Development and Therapy 2021, 15:195-207

Published Date: 14 January 2021

Bioequivalence and Pharmacokinetic Profiles of Generic and Branded Obeticholic Acid in Healthy Chinese Subjects Under Fasting and Fed Conditions

Wang MN, Yu HT, Li YQ, Zeng Y, Yang S, Yang GP, Pei Q, Huang J

Drug Design, Development and Therapy 2021, 15:185-193

Published Date: 14 January 2021

Combination of Sodium Cantharidinate with Cisplatin Synergistically Hampers Growth of Cervical Cancer

Chen X, Zhou M, Fan W, Yang M, Yang L

Drug Design, Development and Therapy 2021, 15:171-183

Published Date: 13 January 2021

Subcutaneous Delivery of High-Dose/Volume Biologics: Current Status and Prospect for Future Advancements

Badkar AV, Gandhi RB, Davis SP, LaBarre MJ

Drug Design, Development and Therapy 2021, 15:159-170

Published Date: 13 January 2021

Capsaicin Inhibits Proliferation and Induces Apoptosis in Breast Cancer by Down-Regulating FBI-1-Mediated NF-κB Pathway

Chen M, Xiao C, Jiang W, Yang W, Qin Q, Tan Q, Lian B, Liang Z, Wei C

Drug Design, Development and Therapy 2021, 15:125-140

Published Date: 12 January 2021

Chronic Obstructive Pulmonary Disease Treatment and Pharmacist-Led Medication Management

Li LC, Han YY, Zhang ZH, Zhou WC, Fang HM, Qu J, Kan LD

Drug Design, Development and Therapy 2021, 15:111-124

Published Date: 12 January 2021

Network Pharmacology and Experimental Evidence Identify the Mechanism of Astragaloside IV in Oxaliplatin Neurotoxicity

Xu J, Guan Z, Wang X, Sun D, Li Y, Pei B, Lu Y, Yuan L, Zhang X

Drug Design, Development and Therapy 2021, 15:99-110

Published Date: 12 January 2021

A Review of Drug Therapy in Vestibular Schwannoma

Long J, Zhang Y, Huang X, Ren J, Zhong P, Wang B

Drug Design, Development and Therapy 2021, 15:75-85

Published Date: 8 January 2021

Inhibition of Pre-B Cell Colony Enhancing Factor Reduces Lung Injury in Rats Receiving Cardiopulmonary Bypass

Lu C, Yang W, Zhou J, Zhang Z, Gong Y, Hu F, Yu W, Dong X

Drug Design, Development and Therapy 2021, 15:51-60

Published Date: 7 January 2021

RASSF1A Enhances Chemosensitivity of NSCLC Cells Through Activating Autophagy by Regulating MAP1S to Inactivate Keap1-Nrf2 Pathway

Wang J, Zhang X, Yang F, Yang Y, Wang T, Liu W, Zhou H, Zhao W

Drug Design, Development and Therapy 2021, 15:21-35

Published Date: 6 January 2021

Current Status and Perspectives of Protease Inhibitors and Their Combination with Nanosized Drug Delivery Systems for Targeted Cancer Therapy

Rudzińska M, Daglioglu C, Savvateeva LV, Kaci FN, Antoine R, Zamyatnin Jr AA

Drug Design, Development and Therapy 2021, 15:9-20

Published Date: 6 January 2021

Tanshinone IIA Ameliorates Streptozotocin-Induced Diabetic Nephropathy, Partly by Attenuating PERK Pathway-Induced Fibrosis

Xu S, He L, Ding K, Zhang L, Xu X, Wang S, Qian X

Drug Design, Development and Therapy 2020, 14:5773-5782

Published Date: 31 December 2020

RGD-Conjugated Resveratrol HSA Nanoparticles as a Novel Delivery System in Ovarian Cancer Therapy

Long Q, Zhu W, Guo L, Pu L

Drug Design, Development and Therapy 2020, 14:5747-5756

Published Date: 30 December 2020

Low-Dose Triple Antihypertensive Combination Therapy in Patients with Hypertension: A Randomized, Double-Blind, Phase II Study

Hong SJ, Sung KC, Lim SW, Kim SY, Kim W, Shin J, Park S, Kim HY, Rhee MY

Drug Design, Development and Therapy 2020, 14:5735-5746

Published Date: 31 December 2020

Pretreatment with Lactobacillus fermentum XY18 Relieves Gastric Injury Induced by HCl/Ethanol in Mice via Antioxidant and Anti-Inflammatory Mechanisms

Wang R, Zhou K, Xiong R, Yang Y, Yi R, Hu J, Liao W, Zhao X

Drug Design, Development and Therapy 2020, 14:5721-5734

Published Date: 30 December 2020

Effective Tacrolimus Treatment for Patients with Non-Severe Aplastic Anemia That is Refractory/Intolerant to Cyclosporine A: A Retrospective Study

Du Y, Huang Y, Zhou W, Liu X, Chen F, Yang C, Chen M, Ruan J, Han B

Drug Design, Development and Therapy 2020, 14:5711-5719

Published Date: 30 December 2020

Intravenous Iron Isomaltoside 1000 Reduces Postoperative Anemia in Patients Undergoing Elective Urologic Surgery and Those with Urosepsis

Goh HJ, Lee KS, Kim TH, Kim KN, Lim HJ, Kim KS, Yang WJ, Jo JK

Drug Design, Development and Therapy 2020, 14:5679-5687

Published Date: 23 December 2020

Curcumin- and Cyclopamine-Loaded Liposomes to Enhance Therapeutic Efficacy Against Hepatic Fibrosis

Zhang T, Li Y, Song Y, Chen X, Li J, Peng Q, He J, Fei X

Drug Design, Development and Therapy 2020, 14:5667-5678

Published Date: 23 December 2020

Preventive Effect of Lactobacillus acidophilus XY27 on DSS-Induced Ulcerative Colitis in Mice

Hu T, Wang H, Xiang C, Mu J, Zhao X

Drug Design, Development and Therapy 2020, 14:5645-5657

Published Date: 22 December 2020

Paeoniflorin Alleviates Abnormalities in Rats with Functional Dyspepsia by Stimulating the Release of Acetylcholine

Zou X, Wang Y, Wang Y, Yang J, Guo H, Cai Z

Drug Design, Development and Therapy 2020, 14:5623-5632

Published Date: 22 December 2020

Sinapultide-Loaded Microbubbles Combined with Ultrasound to Attenuate Lipopolysaccharide-Induced Acute Lung Injury in Mice

Liu D, Chen Y, Li F, Chen C, Wei P, Xiao D, Han B

Drug Design, Development and Therapy 2020, 14:5611-5622

Published Date: 22 December 2020

Clopidogrel-Induced Gastric Injury in Rats is Attenuated by Stable Gastric Pentadecapeptide BPC 157

Wu H, Wei M, Li N, Lu Q, Shrestha SM, Tan J, Zhang Z, Wu G, Shi R

Drug Design, Development and Therapy 2020, 14:5599-5610

Published Date: 21 December 2020

Agomelatine Attenuates Isoflurane-Induced Inflammation and Damage in Brain Endothelial Cells

Cheng F, Chang H, Yan F, Yang A, Liu J, Liu Y

Drug Design, Development and Therapy 2020, 14:5589-5598

Published Date: 18 December 2020

Beneficial Effects of Echinacoside on Diabetic Cardiomyopathy in Diabetic Db/Db Mice

Zhang X, Hao Y

Drug Design, Development and Therapy 2020, 14:5575-5587

Published Date: 18 December 2020

4-Octyl Itaconate Alleviates Lipopolysaccharide-Induced Acute Lung Injury in Mice by Inhibiting Oxidative Stress and Inflammation

Li Y, Chen X, Zhang H, Xiao J, Yang C, Chen W, Wei Z, Chen X, Liu J

Drug Design, Development and Therapy 2020, 14:5547-5558

Published Date: 17 December 2020

The Effect of Switching from Tenofovir Disoproxil Fumarate (TDF) to Tenofovir Alafenamide (TAF) on Liver Enzymes, Glucose, and Lipid Profile

Squillace N, Ricci E, Menzaghi B, De Socio GV, Passerini S, Martinelli C, Mameli MS, Maggi P, Falasca K, Cordier L, Celesia BM, Salomoni E, Di Biagio A, Pellicanò GF, Bonfanti P

Drug Design, Development and Therapy 2020, 14:5515-5520

Published Date: 15 December 2020

A Review of Biomimetic Nanoparticle Drug Delivery Systems Based on Cell Membranes

Zhang M, Du Y, Wang S, Chen B

Drug Design, Development and Therapy 2020, 14:5495-5503

Published Date: 14 December 2020

Naringenin Prevents Propofol Induced Neurodegeneration in Neonatal Mice Brain and Long-Term Neurocognitive Impacts on Adults

Zou L, Ning M, Wang W, Zheng Y, Ma L, Lv J

Drug Design, Development and Therapy 2020, 14:5469-5482

Published Date: 10 December 2020

The Median Effective Dose of Oxytocin Needed to Prevent Uterine Atony During Cesarean Delivery in Elderly Parturients

Wei CN, Deng JL, Dong JH, Ping ZP, Chen XZ

Drug Design, Development and Therapy 2020, 14:5451-5458

Published Date: 8 December 2020

Budesonide/Formoterol Anti-Inflammatory Reliever and Maintenance or Fluticasone Propionate/Salmeterol Plus As-Needed, Short-Acting β2 Agonist: Real-World Effectiveness in pAtients without Optimally Controlled asThma (REACT) Study

Cheng SL, Ho ML, Lai YF, Wang HC, Hsu JY, Liu SF, Huang MS, Lee CH, Lin CH, Hang LW, Liu YC, Yang KY, Wang JH

Drug Design, Development and Therapy 2020, 14:5441-5450

Published Date: 8 December 2020

Xanthohumol Inhibits TGF-β1-Induced Cardiac Fibroblasts Activation via Mediating PTEN/Akt/mTOR Signaling Pathway

Jiang C, Xie N, Sun T, Ma W, Zhang B, Li W

Drug Design, Development and Therapy 2020, 14:5431-5439

Published Date: 7 December 2020

Mini-Tablets versus Nanoparticles for Controlling the Release of Amoxicillin: In vitro/In vivo Study

Gaber DA, Alhawas HS, Alfadhel FA, Abdoun SA, Alsubaiyel AM, Alsawi RM

Drug Design, Development and Therapy 2020, 14:5405-5418

Published Date: 7 December 2020

Design and Development of a Behaviorally Active Recombinant Neurotrophic Factor

Pekas NJ, Petersen JL, Sathyanesan M, Newton SS

Drug Design, Development and Therapy 2020, 14:5393-5403

Published Date: 4 December 2020

Ruthenium Complexes as Anticancer Agents: A Brief History and Perspectives

Lee SY, Kim CY, Nam TG

Drug Design, Development and Therapy 2020, 14:5375-5392

Published Date: 3 December 2020

The Skeletal Effects of Short-Term Triple Therapy in a Rat Model of Gastric Ulcer Induced by Helicobacter pylori Infection

Ekeuku SO, Thong BKS, Quraisiah A, Annuar F, Hanafiah A, Nur Azlina MF, Chin KY

Drug Design, Development and Therapy 2020, 14:5359-5366

Published Date: 3 December 2020

The Inhibitory Effects of Juglanin on Adipogenesis in 3T3-L1 Adipocytes

Wang G, Wu B, Xu W, Jin X, Wang K, Wang H

Drug Design, Development and Therapy 2020, 14:5349-5357

Published Date: 2 December 2020

Resveratrol Ameliorates Systemic Sclerosis via Suppression of Fibrosis and Inflammation Through Activation of SIRT1/mTOR Signaling

Yao Q, Wu Q, Xu X, Xing Y, Liang J, Lin Q, Huang M, Chen Y, Lin B, Chen W

Drug Design, Development and Therapy 2020, 14:5337-5348

Published Date: 2 December 2020

Modulation of Drug Release from Natural Polymer Matrices by Response Surface Methodology: in vitro and in vivo Evaluation

Moin A, Gangadharappa HV, Adnan M, Rizvi SM, Ashraf SA, Patel M, Abu Lila AS, Allam AN

Drug Design, Development and Therapy 2020, 14:5325-5336

Published Date: 1 December 2020

Cytotoxic and Antiproliferative Effects of β-Mangostin on Rat C6 Glioma Cells Depend on Oxidative Stress Induction via PI3K/AKT/mTOR Pathway Inhibition

Li K, Wu L, Chen Y, Li Y, Wang Q, Li M, Hao K, Zhang W, Jiang S, Wang Z

Drug Design, Development and Therapy 2020, 14:5315-5324

Published Date: 1 December 2020

Evaluation of the Effect of Hypericum triquetrifolium Turra on Memory Impairment Induced by Chronic Psychosocial Stress in Rats: Role of BDNF

Alzoubi KH, Abdel-Hafiz L, Khabour OF, El-Elimat T, Alzubi MA, Alali FQ

Drug Design, Development and Therapy 2020, 14:5299-5314

Published Date: 1 December 2020

Edaravone and Acetovanillone Upregulate Nrf2 and PI3K/Akt/mTOR Signaling and Prevent Cyclophosphamide Cardiotoxicity in Rats

Hassanein EHM, Abd El-Ghafar OAM, Ahmed MA, Sayed AM, Gad-Elrab WM, Ajarem JS, Allam AA, Mahmoud AM

Drug Design, Development and Therapy 2020, 14:5275-5288

Published Date: 30 November 2020

Effects of Saikosaponin D on CYP1A2 and CYP2D6 in HepaRG Cells

Li H, Tang Y, Wang Y, Wei W, Yin C, Tang F

Drug Design, Development and Therapy 2020, 14:5251-5258

Published Date: 26 November 2020

In Ovo and In Silico Evaluation of the Anti-Angiogenic Potential of Syringin

Aventurado CA, Billones JB, Vasquez RD, Castillo AL

Drug Design, Development and Therapy 2020, 14:5189-5204

Published Date: 25 November 2020

Pharmacokinetic/Pharmacodynamic Interactions Between Evogliptin and Glimepiride in Healthy Male Subjects

Yoo H, Kim Y, Jang IJ, Yu KS, Lee S

Drug Design, Development and Therapy 2020, 14:5179-5187

Published Date: 24 November 2020

Agonism of Gpr40 Protects the Capacities of Epidermal Stem Cells (ESCs) Against Ultraviolet-B (UV-B)

Sun C, Li Y, Li X, Sun J

Drug Design, Development and Therapy 2020, 14:5143-5153

Published Date: 24 November 2020

Functional Measurement of CYP2C9 and CYP3A4 Allelic Polymorphism on Sildenafil Metabolism

Tang P, Zheng X, Hu X, Yang C, Chen Z, Qian J, Cai J, Hu G

Drug Design, Development and Therapy 2020, 14:5129-5141

Published Date: 24 November 2020

Research on the Potential Mechanism of Gentiopicroside Against Gastric Cancer Based on Network Pharmacology

Huang Y, Jiatong Lin, Yi W, Liu Q, Cao L, Yan Y, Fu A, Huang T, Lyu Y, Huang Q, Wang J

Drug Design, Development and Therapy 2020, 14:5109-5118

Published Date: 23 November 2020

COVID-19 Clinical Trials Registered Worldwide for Drug Intervention: An Overview and Characteristic Analysis

Wang B, Lai J, Yan X, Jin F, Yi B, An C, Li Y, Yao C

Drug Design, Development and Therapy 2020, 14:5097-5108

Published Date: 19 November 2020

Acacetin Induces Apoptosis in Human Osteosarcoma Cells by Modulation of ROS/JNK Activation

Wang S, Lin B, Liu W, Wei G, Li Z, Yu N, Xue X, Ji G

Drug Design, Development and Therapy 2020, 14:5077-5085

Published Date: 18 November 2020

QbD-Based Investigation of Dermal Semisolid in situ Film-Forming Systems for Local Anaesthesia

Kovács A, Kis N, Budai-Szűcs M, Gácsi A, Csányi E, Csóka I, Berkó S

Drug Design, Development and Therapy 2020, 14:5059-5076

Published Date: 18 November 2020

Repurposing Anti-Cancer Drugs for COVID-19 Treatment

Borcherding N, Jethava Y, Vikas P

Drug Design, Development and Therapy 2020, 14:5045-5058

Published Date: 18 November 2020

Efficacy and Safety of Nebivolol and Rosuvastatin Combination Treatment in Patients with Concomitant Hypertension and Hyperlipidemia

Rhee MY, Kim CH, Ahn Y, Shin JH, Han SH, Kang HJ, Hong SJ, Kim HY

Drug Design, Development and Therapy 2020, 14:5005-5017

Published Date: 17 November 2020

Synthesis and Cytotoxic Property of Annonaceous Acetogenin Glycoconjugates

Shi JF, Wu P, Cheng XL, Wei XY, Jiang ZH

Drug Design, Development and Therapy 2020, 14:4993-5004

Published Date: 17 November 2020

Palmatine as an Agent Against Metabolic Syndrome and Its Related Complications: A Review

Ekeuku SO, Pang KL, Chin KY

Drug Design, Development and Therapy 2020, 14:4963-4974

Published Date: 17 November 2020

Chrysophanol Inhibits the Progression of Diabetic Nephropathy via Inactivation of TGF-β Pathway

Guo C, Wang Y, Piao Y, Rao X, Yin D

Drug Design, Development and Therapy 2020, 14:4951-4962

Published Date: 16 November 2020

HIF-1α is a Potential Molecular Target for Herbal Medicine to Treat Diseases

Li RL, He LY, Zhang Q, Liu J, Lu F, Duan HXY, Fan LH, Peng W, Huang YL, Wu CJ

Drug Design, Development and Therapy 2020, 14:4915-4949

Published Date: 16 November 2020

Eldecalcitol Inhibits LPS-Induced NLRP3 Inflammasome-Dependent Pyroptosis in Human Gingival Fibroblasts by Activating the Nrf2/HO-1 Signaling Pathway

Huang C, Zhang C, Yang P, Chao R, Yue Z, Li C, Guo J, Li M

Drug Design, Development and Therapy 2020, 14:4901-4913

Published Date: 13 November 2020

iTRAQ-Based Quantitative Proteomic Analysis of Intestines in Murine Polymicrobial Sepsis with Hydrogen Gas Treatment

Jiang Y, Bian Y, Lian N, Wang Y, Xie K, Qin C, Yu Y

Drug Design, Development and Therapy 2020, 14:4885-4900

Published Date: 12 November 2020

Comparative Analysis of the Effectiveness of Some Biological Injected Wound Healing Stimulators and Criteria for Its Evaluation

Silina EV, Manturova NE, Litvitskiy PF, Stupin VA

Drug Design, Development and Therapy 2020, 14:4869-4883

Published Date: 12 November 2020

Indole: The After Next Scaffold of Antiplasmodial Agents?

Surur AS, Huluka SA, Mitku ML, Asres K

Drug Design, Development and Therapy 2020, 14:4855-4867

Published Date: 11 November 2020

Downregulation of miR-200a Protects Mouse Leydig Cells Against Triptolide by Triggering Autophagy

Miao H, Miao C, Han J, Li N

Drug Design, Development and Therapy 2020, 14:4845-4854

Published Date: 10 November 2020

Development and Validation of UHPLC-MS/MS Assay for Therapeutic Drug Monitoring of High-dose Methotrexate in Children with Acute Lymphoblastic Leukemia

Lian LJ, Lin B, Cui X, He J, Wang Z, Lin XD, Ye WJ, Chen RJ, Sun W

Drug Design, Development and Therapy 2020, 14:4835-4843

Published Date: 10 November 2020

Intermedin Alleviates Renal Ischemia-Reperfusion Injury and Enhances Neovascularization in Wistar Rats

Wang Y, Mi Y, Tian J, Qiao X, Su X, Kang J, Wu Z, Wang G, Zhou X, Zhou Y, Li R

Drug Design, Development and Therapy 2020, 14:4825-4834

Published Date: 10 November 2020

In Vitro and In Vivo Rat Model Assessments of the Effects of Vonoprazan on the Pharmacokinetics of Venlafaxine

Chen F, Jiang H, Xu J, Wang S, Meng D, Geng P, Dai D, Zhou Q, Zhou Y

Drug Design, Development and Therapy 2020, 14:4815-4824

Published Date: 10 November 2020

Homoharringtonine Exerts an Antimyeloma Effect by Promoting Excess Parkin-Dependent Mitophagy

Zhang Y, Huang N, Xu J, Zheng W, Cui X

Drug Design, Development and Therapy 2020, 14:4749-4763

Published Date: 5 November 2020

Pharmacological Activity and Mechanism of Tanshinone IIA in Related Diseases

Guo R, Li L, Su J, Li S, Duncan SE, Liu Z, Fan G

Drug Design, Development and Therapy 2020, 14:4735-4748

Published Date: 5 November 2020

Sanguinarine Attenuates Neuropathic Pain by Inhibiting P38 MAPK Activated Neuroinflammation in Rat Model

Yu C, Li P, Wang YX, Zhang KG, Zheng ZC, Liang LS

Drug Design, Development and Therapy 2020, 14:4725-4733

Published Date: 4 November 2020

Interaction of Analgesic Effects of Dezocine and Sufentanil for Relief of Postoperative Pain: A Pilot Study

Zhu H, Chen Y, Huang S, Sun X

Drug Design, Development and Therapy 2020, 14:4717-4724

Published Date: 3 November 2020

Cerebral Oxygen Changes in Neonates During Immediate Transition After Birth and Early Life: An Observational Study

Xue H, Wu Z, Yao J, Zhao A, Zheng L, Yin X, Wang F, Zhao P

Drug Design, Development and Therapy 2020, 14:4703-4715

Published Date: 2 November 2020

In vitro and in vivo Effects of Artesunate on Echinococcus granulosus Protoscoleces and Metacestodes

Wen L, Lv G, Zhao J, Lu S, Gong Y, Li Y, Zheng H, Chen B, Gao H, Tian C, Wang J

Drug Design, Development and Therapy 2020, 14:4685-4694

Published Date: 2 November 2020

The Effects of Short-Chain Fatty Acids on Rat Colonic Hypermotility Induced by Water Avoidance Stress

Yuan F, Tan W, Ren H, Yan L, Wang Y, Luo H

Drug Design, Development and Therapy 2020, 14:4671-4684

Published Date: 2 November 2020

Pristimerin Suppresses Trophoblast Cell Epithelial–Mesenchymal Transition via miR-542-5p/EGFR Axis

Shu C, Yu X, Cheng S, Jing J, Hu C, Pang B

Drug Design, Development and Therapy 2020, 14:4659-4670

Published Date: 2 November 2020

Stoichiometrically Governed Curcumin Solid Dispersion and Its Cytotoxic Evaluation on Colorectal Adenocarcinoma Cells

Mohamed JMM, Alqahtani A, Ahmad F, Krishnaraju V, Kalpana K

Drug Design, Development and Therapy 2020, 14:4639-4658

Published Date: 2 November 2020

Cinnamaldehyde Inhibits the Function of Osteosarcoma by Suppressing the Wnt/β-Catenin and PI3K/Akt Signaling Pathways

Huang Y, Chen J, Yang S, Tan T, Wang N, Wang Y, Zhang L, Yang C, Huang H, Luo J, Luo X

Drug Design, Development and Therapy 2020, 14:4625-4637

Published Date: 30 October 2020

Tranilast Inhibits Pulmonary Fibrosis by Suppressing TGFβ/SMAD2 Pathway

Kato M, Takahashi F, Sato T, Mitsuishi Y, Tajima K, Ihara H, Nurwidya F, Baskoro H, Murakami A, Kobayashi I, Hidayat M, Shimada N, Sasaki S, Mineki R, Fujimura T, Kumasaka T, Niwa SI, Takahashi K

Drug Design, Development and Therapy 2020, 14:4593-4603

Published Date: 29 October 2020

Anti-Breast Cancer Effect of 2-Dodecyl-6-Methoxycyclohexa-2,5-Diene-1,4-Dione in vivo and in vitro Through MAPK Signaling Pathway [Corrigendum]

Zhou X, Wu X, Qin L, Lu S, Zhang H, Wei J, Chen L, Jiang L, Wu Y, Chen C, Huang R

Drug Design, Development and Therapy 2020, 14:4575-4577

Published Date: 28 October 2020

Novel Fast and Reliable Method for Nano-Erythrosome Production Using Shear Force

Capossela S, Mathew V, Boos M, Bertolo A, Krupkova O, Stoyanov JV

Drug Design, Development and Therapy 2020, 14:4547-4560

Published Date: 28 October 2020

S-Allylmercaptocysteine Targets Nrf2 in Osteoarthritis Treatment Through NOX4/NF-κB Pathway

Yang G, Sun S, Wang J, Li W, Wang X, Yuan L, Li S

Drug Design, Development and Therapy 2020, 14:4533-4546

Published Date: 28 October 2020

Analgesic and Antiallodynic Effects of 4-Fluoro-N-(4-Sulfamoylbenzyl) Benzene Sulfonamide in a Murine Model of Pain

Ur Rehman N, al-Rashida M, Tokhi A, Ahmed Z, Subhan F, Abbas M, Arshid MA, Rauf K

Drug Design, Development and Therapy 2020, 14:4511-4518

Published Date: 27 October 2020

Pharmacokinetic/Pharmacodynamic Interaction Between Evogliptin and Pioglitazone in Healthy Male Subjects

Hwang I, Kim Y, Yoo H, Jang IJ, Yu KS, Lee S

Drug Design, Development and Therapy 2020, 14:4493-4502

Published Date: 23 October 2020

Synthesis, Cytotoxic Analysis, and Molecular Docking Studies of Tetrazole Derivatives via N-Mannich Base Condensation as Potential Antimicrobials

Atef Hatamleh A, Al Farraj D, Salah Al-Saif S, Chidambaram S, Radhakrishnan S, Akbar I

Drug Design, Development and Therapy 2020, 14:4477-4492

Published Date: 23 October 2020

Resveratrol Protects Osteoblasts Against Dexamethasone-Induced Cytotoxicity Through Activation of AMP-Activated Protein Kinase

Wang L, Li Q, Yan H, Jiao G, Wang H, Chi H, Zhou H, Chen L, Shan Y, Chen Y

Drug Design, Development and Therapy 2020, 14:4451-4463

Published Date: 23 October 2020

LC-MS/MS Estimation of the Anti-Cancer Agent Tandutinib Levels in Human Liver Microsomes: Metabolic Stability Evaluation Assay

Attwa MW, Abdelhameed AS, Al-Shakliah NS, Kadi AA

Drug Design, Development and Therapy 2020, 14:4439-4449

Published Date: 23 October 2020

Metabolic Activation and Covalent Protein Binding of Berberrubine: Insight into the Underlying Mechanism Related to Its Hepatotoxicity

Wang K, Rao J, Zhang T, Gao Q, Zhang J, Guang C, Ding L, Qiu F

Drug Design, Development and Therapy 2020, 14:4423-4438

Published Date: 22 October 2020

Enteric-Coated Strategies in Colorectal Cancer Nanoparticle Drug Delivery System

Wathoni N, Nguyen AN, Rusdin A, Umar AK, Mohammed AFA, Motoyama K, Joni IM, Muchtaridi M

Drug Design, Development and Therapy 2020, 14:4387-4405

Published Date: 21 October 2020

Validated Microwell-Based Spectrofluorimetric Method for Quantification of Ravidasvir (New Anti-Chronic Hepatitis C Virus-GT4) in Rat Plasma and Its Application to Pharmacokinetic Study

Hefnawy M, Al-Shehri M, Al-Rashood S, Hammad S, Alanazi M, Alsaif N, Mohammed M, Obaidullah A, El-Gendy M

Drug Design, Development and Therapy 2020, 14:4377-4385

Published Date: 20 October 2020

ISL Induces Apoptosis and Autophagy in Hepatocellular Carcinoma via Downregulation of PI3K/AKT/mTOR Pathway in vivo and in vitro

Song L, Luo Y, Li S, Hong M, Wang Q, Chi X, Yang C

Drug Design, Development and Therapy 2020, 14:4363-4376

Published Date: 20 October 2020

Development, Characterization, and in-vivo Pharmacokinetic Study of Lamotrigine Solid Self-Nanoemulsifying Drug Delivery System

Abdelmonem R, Azer MS, Makky A, Zaghloul A, El-Nabarawi M, Nada A

Drug Design, Development and Therapy 2020, 14:4343-4362

Published Date: 19 October 2020

Proteasome, a Promising Therapeutic Target for Multiple Diseases Beyond Cancer

Cao Y, Zhu H, He R, Kong L, Shao J, Zhuang R, Xi J, Zhang J

Drug Design, Development and Therapy 2020, 14:4327-4342

Published Date: 19 October 2020

Synthesis and Identification of a Novel Peptide, Ac-SDK (Biotin) Proline, That Can Elicit Anti-Fibrosis Effects in Rats Suffering from Silicosis

Wang J, Qian Y, Gao X, Mao N, Geng Y, Lin G, Zhang G, Li H, Yang F, Xu H

Drug Design, Development and Therapy 2020, 14:4315-4326

Published Date: 19 October 2020

Simvastatin-Nicotinamide Co-Crystals: Formation, Pharmaceutical Characterization and in vivo Profile

Khan FM, Ahmad M, Idrees HA

Drug Design, Development and Therapy 2020, 14:4303-4313

Published Date: 19 October 2020

HLJ2 Effectively Ameliorates Colitis-Associated Cancer via Inhibition of NF-κB and Epithelial–Mesenchymal Transition

Song H, Tang X, Li X, Wang Y, Deng A, Wang W, Zhang H, Qin H, Wu LQ

Drug Design, Development and Therapy 2020, 14:4291-4302

Published Date: 15 October 2020

Effects of Anisodine Hydrobromide on the Cardiovascular and Respiratory Functions in Conscious Dogs

Liu Y, Wang L, Wan F, Yang N

Drug Design, Development and Therapy 2020, 14:4263-4276

Published Date: 13 October 2020

EGCG Upregulates UCP3 Levels to Protect MIN6 Pancreatic Islet Cells from Interleukin-1β-Induced Apoptosis

Jia X, Luo Z, Gao Y, Liu H, Liu X, Mai W, Liu H, Zheng Q

Drug Design, Development and Therapy 2020, 14:4251-4261

Published Date: 13 October 2020

Clinical Outcome of Systemic Treatment for Advanced Soft Tissue Sarcoma: Real-Life Perspective in Japan

Nakamura T, Asanuma K, Hagi T, Sudo A

Drug Design, Development and Therapy 2020, 14:4215-4220

Published Date: 12 October 2020

Effect of Platelet-Activating Factor on Barrier Function of ARPE-19 Cells

Zhang F, Liu L, Zhang H, Liu ZL

Drug Design, Development and Therapy 2020, 14:4205-4214

Published Date: 12 October 2020

Pristimerin Inhibits Osteoclast Differentiation and Bone Resorption in vitro and Prevents Ovariectomy-Induced Bone Loss in vivo

Sun P, Yang Q, Wang Y, Peng J, Zhao K, Jia Y, Zhang T, Lu X, Han W, Qian Y

Drug Design, Development and Therapy 2020, 14:4189-4203

Published Date: 9 October 2020

Ginkgolide B Ameliorates Myocardial Ischemia Reperfusion Injury in Rats via Inhibiting Endoplasmic Reticulum Stress [Retraction]

Guo C, Zhang J, Zhang P, Si A, Zhang Z, Zhao L, Lv F, Zhao G

Drug Design, Development and Therapy 2020, 14:4131-4132

Published Date: 7 October 2020

Dexamethasone-Loaded Thermosensitive Hydrogel Suppresses Inflammation and Pain in Collagen-Induced Arthritis Rats

Wang QS, Xu BX, Fan KJ, Li YW, Wu J, Wang TY

Drug Design, Development and Therapy 2020, 14:4101-4113

Published Date: 5 October 2020

[6]-Gingerol Ameliorates Cisplatin-Induced Pica by Regulating the TPH/MAO-A/SERT/5-HT/5-HT3 Receptor System in Rats

Cheng Q, Feng X, Meng Q, Li Y, Chen Siqi, Wang G, Nie K

Drug Design, Development and Therapy 2020, 14:4085-4099

Published Date: 2 October 2020

A Review on the Role of Denosumab in Fracture Prevention

Pang KL, Low NY, Chin KY

Drug Design, Development and Therapy 2020, 14:4029-4051

Published Date: 1 October 2020

Multifunctional Islet Transplantation Hydrogel Encapsulating A20 High-Expressing Islets

Bai X, Pei Q, Pu C, Chen Y, He S, Wang B

Drug Design, Development and Therapy 2020, 14:4021-4027

Published Date: 29 September 2020

Umbelliferone Inhibits Spermatogenic Defects and Testicular Injury in Lead-Intoxicated Rats by Suppressing Oxidative Stress and Inflammation, and Improving Nrf2/HO-1 Signaling

Alotaibi MF, Al-Joufi F, Abou Seif HS, Alzoghaibi MA, Djouhri L, Ahmeda AF, Mahmoud AM

Drug Design, Development and Therapy 2020, 14:4003-4019

Published Date: 29 September 2020

Challenges for Mesenchymal Stem Cell-Based Therapy for COVID-19

Li C, Zhao H, Wang B

Drug Design, Development and Therapy 2020, 14:3995-4001

Published Date: 29 September 2020

DPP-4 Inhibitor Linagliptin Ameliorates Oxidized LDL-Induced THP-1 Macrophage Foam Cell Formation and Inflammation

Wang H, Li Y, Zhang X, Xu Z, Zhou J, Shang W

Drug Design, Development and Therapy 2020, 14:3929-3940

Published Date: 25 September 2020

Antiemetic Prophylaxis with Fosaprepitant and 5-HT3-Receptor Antagonists in Pediatric Patients Undergoing Autologous Hematopoietic Stem Cell Transplantation

Cabanillas Stanchi KM, Willier S, Vek J, Schlegel P, Queudeville M, Rieflin N, Klaus V, Gansel M, Rupprecht JV, Flaadt T, Binder V, Feuchtinger T, Lang P, Handgretinger R, Döring M

Drug Design, Development and Therapy 2020, 14:3915-3927

Published Date: 25 September 2020

Phoenixin 14 Inhibits High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Experimental Mice

Yang F, Huang P, Shi L, Liu F, Tang A, Xu S

Drug Design, Development and Therapy 2020, 14:3865-3874

Published Date: 22 September 2020

Protective Effect of Pravastatin on Myocardial Ischemia Reperfusion Injury by Regulation of the miR-93/Nrf2/ARE Signal Pathway

Liu Z, Zhang F, Zhao L, Zhang X, Li Y, Liu L

Drug Design, Development and Therapy 2020, 14:3853-3864

Published Date: 22 September 2020

Synergistic Cytotoxic Effect from Combination of Wedelolactone and Cisplatin in HeLa Cell Line: A Novel Finding

Sarwar S, Yu JQ, Nadeem H, Huq F

Drug Design, Development and Therapy 2020, 14:3841-3852

Published Date: 22 September 2020

Bacterial Natural Compounds with Anti-Inflammatory and Immunomodulatory Properties (Mini Review)

Jenab A, Roghanian R, Emtiazi G

Drug Design, Development and Therapy 2020, 14:3787-3801

Published Date: 18 September 2020

Effect of 4-Fluoro-N-(4-Sulfamoylbenzyl) Benzene Sulfonamide on Acquisition and Expression of Nicotine-Induced Behavioral Sensitization and Striatal Adenosine Levels

Ur Rehman N, Abbas M, al-Rashida M, Tokhi A, Arshid MA, Khan MS, Ahmad I, Rauf K

Drug Design, Development and Therapy 2020, 14:3777-3786

Published Date: 17 September 2020

Exosomes Derived from Mesenchymal Stem Cells Protect the Myocardium Against Ischemia/Reperfusion Injury Through Inhibiting Pyroptosis

Tang J, Jin L, Liu Y, Li L, Ma Y, Lu L, Ma J, Ding P, Yang X, Liu J, Yang J

Drug Design, Development and Therapy 2020, 14:3765-3775

Published Date: 16 September 2020

The Potential Effects of Aliskiren on Atrial Remodeling Induced by Chronic Intermittent Hypoxia in Rats

Miao S, Yang Y, Li R, Yin L, Zhang K, Cheng L, Xu X, Wang W, Zhao Z, Li G

Drug Design, Development and Therapy 2020, 14:3755-3764

Published Date: 16 September 2020

Astragaloside IV: An Effective Drug for the Treatment of Cardiovascular Diseases

Tan YQ, Chen HW, Li J

Drug Design, Development and Therapy 2020, 14:3731-3746

Published Date: 15 September 2020

Synthesis and Bioactivity of N-(4-Chlorophenyl)-4-Methoxy-3-(Methylamino) Benzamide as a Potential Anti-HBV Agent

Cui AL, Sun WF, Zhong ZJ, Jin J, Xue ST, Wu S, Li YH, Li ZR

Drug Design, Development and Therapy 2020, 14:3723-3729

Published Date: 15 September 2020

LncRNA SNHG4 Attenuates Inflammatory Responses by Sponging miR-449c-5p and Up-Regulating STAT6 in Microglial During Cerebral Ischemia-Reperfusion Injury

Zhang S, Sun W, Liang Z, Yin X, Ji Z, Chen X, Wei M, Pei L

Drug Design, Development and Therapy 2020, 14:3683-3695

Published Date: 11 September 2020

Emodin Reverses the Epithelial–Mesenchymal Transition of Human Endometrial Stromal Cells by Inhibiting ILK/GSK-3β Pathway

Zheng Q, Wang J, Li W, Chen X, Chen S, Chen L

Drug Design, Development and Therapy 2020, 14:3663-3672

Published Date: 10 September 2020

Knockdown of lncRNA HOXA-AS3 Suppresses the Progression of Atherosclerosis via Sponging miR-455-5p

Chi K, Zhang J, Sun H, Liu Y, Li Y, Yuan T, Zhang F

Drug Design, Development and Therapy 2020, 14:3651-3662

Published Date: 9 September 2020

Research Status and Outlook of PD-1/PD-L1 Inhibitors for Cancer Therapy

Ai L, Chen J, Yan H, He Q, Luo P, Xu Z, Yang X

Drug Design, Development and Therapy 2020, 14:3625-3649

Published Date: 8 September 2020

Enhancing the Butyrylcholinesterase Activity in HEK-293 Cell Line by Dual-Promoter Vector Decorated on Lipofectamine

Mirzaie V, Eslaminejad T, Babaei H, Nematollahi-Mahani SN

Drug Design, Development and Therapy 2020, 14:3589-3599

Published Date: 4 September 2020

Pinocembrin Ameliorates Cognitive Impairment Induced by Vascular Dementia: Contribution of Reelin-dab1 Signaling Pathway

Kang ZC, Wang HG, Yang YL, Zhao XY, Zhou QM, Yang YL, Yang JY, Du GH

Drug Design, Development and Therapy 2020, 14:3577-3587

Published Date: 4 September 2020

Emodin Retarded Renal Fibrosis Through Regulating HGF and TGFβ–Smad Signaling Pathway

Yang F, Deng L, Li J, Chen M, Liu Y, Hu Y, Zhong W

Drug Design, Development and Therapy 2020, 14:3567-3575

Published Date: 3 September 2020

Ketamine Enhances Intranasal Dexmedetomidine-Induced Sedation in Children: A Randomized, Double-Blind Trial

Qian B, Zheng W, Shi J, Chen Z, Guo Y, Yao Y

Drug Design, Development and Therapy 2020, 14:3559-3565

Published Date: 26 August 2020

LncRNA PVT1 Suppresses the Progression of Renal Fibrosis via Inactivation of TGF-β Signaling Pathway

Cao L, Qin P, Zhang J, Qiao H, Shi P, Huo H

Drug Design, Development and Therapy 2020, 14:3547-3557

Published Date: 26 August 2020

Fatostatin in Combination with Tamoxifen Induces Synergistic Inhibition in ER-Positive Breast Cancer

Liu Y, Zhang N, Zhang H, Wang L, Duan Y, Wang X, Chen T, Liang Y, Li Y, Song X, Li C, Han D, Chen B, Zhao W, Yang Q

Drug Design, Development and Therapy 2020, 14:3535-3545

Published Date: 26 August 2020

Bone-Targeting Liposome-Encapsulated Salvianic Acid A Improves Nonunion Healing Through the Regulation of HDAC3-Mediated Endochondral Ossification

Zhou L, Wu H, Gao X, Zheng X, Chen H, Li H, Peng J, Liang W, Wang W, Qiu Z, Udduttula A, Wu K, Li L, Liu Y, Liu Y

Drug Design, Development and Therapy 2020, 14:3519-3533

Published Date: 26 August 2020

Application of Intravenous Lidocaine in Obese Patients Undergoing Painless Colonoscopy: A Prospective, Randomized, Double-Blind, Controlled Study

Li X, Lv X, Jiang Z, Nie X, Wang X, Li T, Zhang L, Liu S

Drug Design, Development and Therapy 2020, 14:3509-3518

Published Date: 27 August 2020

Exosomes-Coated miR-34a Displays Potent Antitumor Activity in Pancreatic Cancer Both in vitro and in vivo

Zuo L, Tao H, Xu H, Li C, Qiao G, Guo M, Cao S, Liu M, Lin X

Drug Design, Development and Therapy 2020, 14:3495-3507

Published Date: 25 August 2020

Video Education Reduces Pain and Anxiety Levels in Cancer Patients Who First Use Fentanyl Transdermal Patch: A Randomized Controlled Trial

Ye Z, Chen J, Zhang Y, Hu X, Xuan Z, Yang S, Mao X, Rao Y

Drug Design, Development and Therapy 2020, 14:3477-3483

Published Date: 25 August 2020

Analysis of the Doxorubicin and Doxorubicinol in the Plasma of Breast Cancer Patients for Monitoring the Toxicity of Doxorubicin

Harahap Y, Ardiningsih P, Corintias Winarti A, Purwanto DJ

Drug Design, Development and Therapy 2020, 14:3469-3475

Published Date: 25 August 2020

Transarterial Chemoembolization Combined with Sorafenib in Patients with BCLC Stage C Hepatocellular Carcinoma

Liu KC, Hao YH, Lv WF, Jia WD, Ji CS, Zhou CZ, Cheng DL, Xu SB, Gao ZG, Su MX, Shi CS

Drug Design, Development and Therapy 2020, 14:3461-3468

Published Date: 25 August 2020

Levonorgestrel Ameliorates Adenomyosis via lncRNA H19/miR-17/TLR4 Pathway

Liang N, Zhang W, Wang H, Shi W, Wang L, Ma L

Drug Design, Development and Therapy 2020, 14:3449-3460

Published Date: 24 August 2020

Sarsasapogenin Suppresses RANKL-Induced Osteoclastogenesis in vitro and Prevents Lipopolysaccharide-Induced Bone Loss in vivo

Peng J, Zhao K, Zhu J, Wang Y, Sun P, Yang Q, Zhang T, Han W, Hu W, Yang W, Ruan J, Qian Y

Drug Design, Development and Therapy 2020, 14:3435-3447

Published Date: 24 August 2020

Efficacy of Sub-Tenon Micro-Perfusion of Cyclophosphamide in Rabbits with Severe Ocular Inflammation

Zhao L, Peng M, Lin W, Tan Q, Khan MA, Lin D

Drug Design, Development and Therapy 2020, 14:3407-3416

Published Date: 20 August 2020

Galangin Improved Non-Alcoholic Fatty Liver Disease in Mice by Promoting Autophagy

Zhang X, Deng Y, Xiang J, Liu H, Zhang J, Liao J, Chen K, Liu B, Liu J, Pu Y

Drug Design, Development and Therapy 2020, 14:3393-3405

Published Date: 19 August 2020

Cinnamaldehyde Treatment of Prostate Cancer-Associated Fibroblasts Prevents Their Inhibitory Effect on T Cells Through Toll-Like Receptor 4

Mei J, Ma J, Xu Y, Wang Y, Hu M, Ma F, Qin Z, Xue R, Tao N

Drug Design, Development and Therapy 2020, 14:3363-3372

Published Date: 18 August 2020

Cannabis Extract CT-921 Has a High Efficacy–Adverse Effect Profile in a Neuropathic Pain Model

Rouhollahi E, MacLeod BA, Barr AM, Puil E

Drug Design, Development and Therapy 2020, 14:3351-3361

Published Date: 17 August 2020

New Benzofuran N-Acylhydrazone Reduces Cardiovascular Dysfunction in Obese Rats by Blocking TNF-Alpha Synthesis

Costa GC, Montagnoli TL, Da Silva JS, Alencar AKN, Reina Gamba LE, Alves BEO, Silva MMC, Trachez MM, Nascimento JHM, Pimentel-Coelho PM, Mendez-Otero R, Lima LM, Barreiro EJ, Sudo RT, Zapata-Sudo G

Drug Design, Development and Therapy 2020, 14:3337-3350

Published Date: 17 August 2020

Beneficial Effect of Genistein on Diabetes-Induced Brain Damage in the ob/ob Mouse Model

Li R, Ding XW, Geetha T, Al-Nakkash L, Broderick TL, Babu JR

Drug Design, Development and Therapy 2020, 14:3325-3336

Published Date: 17 August 2020

Assessment of a New Ginsenoside Rh2 Nanoniosomal Formulation for Enhanced Antitumor Efficacy on Prostate Cancer: An in vitro Study

Zare-Zardini H, Alemi A, Taheri-Kafrani A, Hosseini SA, Soltaninejad H, Hamidieh AA, Haghi Karamallah M, Farrokhifar M, Farrokhifar M

Drug Design, Development and Therapy 2020, 14:3315-3324

Published Date: 13 August 2020

Dual Targeting of Cell Growth and Phagocytosis by Erianin for Human Colorectal Cancer

Sun Y, Li G, Zhou Q, Shao D, Lv J, Zhou J

Drug Design, Development and Therapy 2020, 14:3301-3313

Published Date: 12 August 2020

Therapeutic Drug Monitoring of Rivastigmine and Donepezil Under Consideration of CYP2D6 Genotype-Dependent Metabolism of Donepezil

Ortner M, Stange M, Schneider H, Schröder C, Buerger K, Müller C, Müller-Sarnowski F, Diehl-Schmid J, Förstl H, Grimmer T, Steimer W

Drug Design, Development and Therapy 2020, 14:3251-3262

Published Date: 11 August 2020

Potential Impact of the Multi-Target Drug Approach in the Treatment of Some Complex Diseases

Makhoba XH, Viegas Jr C, Mosa RA, Viegas FPD, Pooe OJ

Drug Design, Development and Therapy 2020, 14:3235-3249

Published Date: 11 August 2020

A Review on Remdesivir: A Possible Promising Agent for the Treatment of COVID-19

Hashemian SM, Farhadi T, Velayati AA

Drug Design, Development and Therapy 2020, 14:3215-3222

Published Date: 6 August 2020

Suppression of c-Met-Overexpressing Tumors by a Novel c-Met/CD3 Bispecific Antibody

Huang L, Xie K, Li H, Wang R, Xu X, Chen K, Gu H, Fang J

Drug Design, Development and Therapy 2020, 14:3201-3214

Published Date: 7 August 2020

Curcumin Protects Against Radiotherapy-Induced Oxidative Injury to the Skin

Shabeeb D, Musa AE, Abd Ali HS, Najafi M

Drug Design, Development and Therapy 2020, 14:3159-3163

Published Date: 5 August 2020

Bioequivalence Study of Amitriptyline Hydrochloride Tablets in Healthy Chinese Volunteers Under Fasting and Fed Conditions

Zhai Y, Wu L, Zheng Y, Wu M, Huang Y, Huang Q, Shentu J, Zhao Q, Liu J

Drug Design, Development and Therapy 2020, 14:3131-3142

Published Date: 4 August 2020

The PPARγ Agonist Rosiglitazone Enhances the Radiosensitivity of Human Pancreatic Cancer Cells

Wang Z, Shen W, Li X, Feng Y, Qian K, Wang G, Gao Y, Xu X, Zhang S, Yue L, Cao J

Drug Design, Development and Therapy 2020, 14:3099-3110

Published Date: 31 July 2020

Nano-Graphene Oxide-supported APTES-Spermine, as Gene Delivery System, for Transfection of pEGFP-p53 into Breast Cancer Cell Lines

Mirzaie V, Ansari M, Nematollahi-Mahani SN, Moballegh Nasery M, Karimi B, Eslaminejad T, Pourshojaei Y

Drug Design, Development and Therapy 2020, 14:3087-3097

Published Date: 30 July 2020

The Climate is Changing for Metered-Dose Inhalers and Action is Needed

Pritchard JN

Drug Design, Development and Therapy 2020, 14:3043-3055

Published Date: 29 July 2020

Chrysin Attenuates the NLRP3 Inflammasome Cascade to Reduce Synovitis and Pain in KOA Rats

Liao T, Ding L, Wu P, Zhang L, Li X, Xu B, Zhang H, Ma Z, Xiao Y, Wang P

Drug Design, Development and Therapy 2020, 14:3015-3027

Published Date: 28 July 2020

Antiviral Agent Therapy Optimization in Special Populations of COVID-19 Patients

Li L, Wang X, Wang R, Hu Y, Jiang S, Lu X

Drug Design, Development and Therapy 2020, 14:3001-3013

Published Date: 28 July 2020

Cordycepin Inhibits Human Gestational Choriocarcinoma Cell Growth by Disrupting Centrosome Homeostasis

Wang CY, Tsai SW, Chien HH, Chen TY, Sheu SY, So EC, Huang BM

Drug Design, Development and Therapy 2020, 14:2987-3000

Published Date: 27 July 2020

Soluplus-Mediated Diosgenin Amorphous Solid Dispersion with High Solubility and High Stability: Development, Characterization and Oral Bioavailability

Liu P, Zhou J, Chang J, Liu X, Xue H, Wang R, Li Z, Li C, Wang J, Liu C

Drug Design, Development and Therapy 2020, 14:2959-2975

Published Date: 27 July 2020

Enhancement of Antitumor Efficacy of Paclitaxel-Loaded PEGylated Liposomes by N,N-Dimethyl Tertiary Amino Moiety in Pancreatic Cancer

Chen Y, Wang L, Luo S, Hu J, Huang X, Li PW, Zhang Y, Wu C, Tian BL

Drug Design, Development and Therapy 2020, 14:2945-2957

Published Date: 23 July 2020

The Effects of Dexmedetomidine and Ketamine on Oxidative Injuries and Histological Changes Following Blunt Chest Trauma

Kartal S, Kip G, Küçük A, Aşçı SS, Erdem Ö, Arslan M, Kavutçu M

Drug Design, Development and Therapy 2020, 14:2937-2943

Published Date: 23 July 2020

Triptolide Inhibits the Proliferation of HaCaT Cells Induced by IL22 via Upregulating miR-181b-5p

He Q, Zhang B, Hu F, Long J, Shi Q, Pi X, Chen H, Li J

Drug Design, Development and Therapy 2020, 14:2927-2935

Published Date: 22 July 2020

Film-Forming Sprays for Topical Drug Delivery

Umar AK, Butarbutar M, Sriwidodo S, Wathoni N

Drug Design, Development and Therapy 2020, 14:2909-2925

Published Date: 22 July 2020

The Anti-Inflammatory Effect of Different Doses of Aliskiren in Rat Models of Inflammation

Aziz TA, Kareem AA, Othman HH, Ahmed ZA

Drug Design, Development and Therapy 2020, 14:2841-2851

Published Date: 20 July 2020

Lentinan Inhibits AGE-Induced Inflammation and the Expression of Matrix-Degrading Enzymes in Human Chondrocytes

Zhang Z, Zha Z, Zhao Z, Liu W, Li W

Drug Design, Development and Therapy 2020, 14:2819-2829

Published Date: 17 July 2020

Cordycepin Alleviates Anterior Cruciate Ligament Transection (ACLT)-Induced Knee Osteoarthritis Through Regulating TGF-β Activity and Autophagy

Tao XM, Liu PF, Gu HY, Lian DB, Gao L, Tao WW, Yan D, Zhao B

Drug Design, Development and Therapy 2020, 14:2809-2817

Published Date: 17 July 2020

A Synthetic Peptide 2Abz23S29 Reduces Bacterial Titer and Induces Pro-Inflammatory Cytokines in a Murine Model of Urinary Tract Infection

Moazzezy N, Asadi Karam MR, Rafati S, Bouzari S, Oloomi M

Drug Design, Development and Therapy 2020, 14:2797-2807

Published Date: 17 July 2020

Promising Swellable Floating Bupropion Tablets: Formulation, in vitro/in vivo Evaluation and Comparative Pharmacokinetic Study in Human Volunteers

Teaima M, Abdel Hamid MM, Shoman NA, Jasti BR, El-Nabarawi MA

Drug Design, Development and Therapy 2020, 14:2741-2757

Published Date: 14 July 2020

Network Pharmacology-Based Prediction and Verification of the Active Ingredients and Potential Targets of Zuojinwan for Treating Colorectal Cancer

Huang S, Zhang Z, Li W, Kong F, Yi P, Huang J, Mao D, Peng W, Zhang S

Drug Design, Development and Therapy 2020, 14:2725-2740

Published Date: 14 July 2020

The Regulating Mechanism of Chrysophanol on Protein Level of CaM-CaMKIV to Protect PC12 Cells Against Aβ25-35-Induced Damage

Ye T, Gao HW, Xuan WT, Ye S, Zhou P, Li XQ, Wang Y, Song H, Liu YY, Cai B

Drug Design, Development and Therapy 2020, 14:2715-2723

Published Date: 13 July 2020

Ribbon Synapses and Hearing Impairment in Mice After in utero Sevoflurane Exposure

Yuan X, Liu H, Li Y, Li W, Yu H, Shen X

Drug Design, Development and Therapy 2020, 14:2685-2693

Published Date: 8 July 2020

Anti-Breast Cancer Effect of 2-Dodecyl-6-Methoxycyclohexa-2,5-Diene-1,4-Dione in vivo and in vitro Through MAPK Signaling Pathway

Zhou X, Wu X, Qin L, Lu S, Zhang H, Wei J, Chen L, Jiang L, Wu Y, Chen C, Huang R

Drug Design, Development and Therapy 2020, 14:2667-2684

Published Date: 7 July 2020

N-Acetyl-l-Leucine-Polyethyleneimine-Mediated Delivery of CpG Oligodeoxynucleotides 2006 Inhibits RAW264.7 Cell Osteoclastogenesis

Wang H, Yu W, Li H, Zheng Y, Chen Z, Lin H, Shen Y

Drug Design, Development and Therapy 2020, 14:2657-2665

Published Date: 7 July 2020

Evaluation of Bioequivalency and Pharmacokinetic Parameters for Two Formulations of Glimepiride 1-mg in Chinese Subjects

Ju G, Yan K, Xu Y, Chen S, Zheng Z, Qiu W

Drug Design, Development and Therapy 2020, 14:2637-2644

Published Date: 6 July 2020

The Expression and Therapeutic Potential of Checkpoint Kinase 2 in Laryngeal Squamous Cell Carcinoma

Tian Y, Wang Y, Xu S, Guan C, Zhang Q, Li W

Drug Design, Development and Therapy 2020, 14:2613-2622

Published Date: 6 July 2020

Structural Insight into the Mechanism of 4-Aminoquinolines Selectivity for the alpha2A-Adrenoceptor

Li Z, Li J, Liu L, Deng W, Liu Q, Liu R, Zhang W, He Z, Fan L, Yang Y, Duan Y, Hou H, Wang X, Yang Z, Wang X, Chen S, Wang Y, Huang N, Chen J

Drug Design, Development and Therapy 2020, 14:2585-2594

Published Date: 3 July 2020

Melatonin Alleviates Neuronal Damage After Intracerebral Hemorrhage in Hyperglycemic Rats

Liang F, Wang J, Zhu X, Wang Z, Zheng J, Sun Z, Xu S, Zhang J, Zhou J, Shi L

Drug Design, Development and Therapy 2020, 14:2573-2584

Published Date: 2 July 2020

Effects of Calcium and Annatto Tocotrienol Supplementation on Bone Loss Induced by Pantoprazole in Male Rats

Chin KY, Thong BKS, Kamalulloh RF, Mohamad NV, Wong SK, Mohd Arlamsyah A, Triliana R, Soelaiman IN

Drug Design, Development and Therapy 2020, 14:2561-2572

Published Date: 2 July 2020

Impact of Administration Time and Kv7 Subchannels on the Cardioprotective Efficacy of Kv7 Channel Inhibition

Hansen J, Johnsen J, Nielsen JM, Sørensen CB, Elkjær CC, Jespersen NR, Bøtker HE

Drug Design, Development and Therapy 2020, 14:2549-2560

Published Date: 2 July 2020

Synthesis and Biological Evaluations of Monocarbonyl Curcumin Inspired Pyrazole Analogues as Potential Anti-Colon Cancer Agent

Min Z, Zhu Y, Hong X, Yu Z, Ye M, Yuan Q, Hu X

Drug Design, Development and Therapy 2020, 14:2517-2534

Published Date: 29 June 2020

Management of Pediatric Systemic Lupus Erythematosus: Focus on Belimumab

Guzman M, Hui-Yuen JS

Drug Design, Development and Therapy 2020, 14:2503-2513

Published Date: 25 June 2020

Remogliflozin Etabonate in the Treatment of Type 2 Diabetes: Design, Development, and Place in Therapy

Mohan V, Mithal A, Joshi SR, Aravind SR, Chowdhury S

Drug Design, Development and Therapy 2020, 14:2487-2501

Published Date: 24 June 2020

Are Laboratory Parameter (Biomarker) Values Similar to the Healthy Volunteer Reference Range in Individuals with Diabetes

Brott DA, Goodman MJ, Hermann RP, Anderson I, Kiazand A

Drug Design, Development and Therapy 2020, 14:2473-2486

Published Date: 24 June 2020

Berberine Attenuates Arterial Plaque Formation in Atherosclerotic Rats with Damp-Heat Syndrome via Regulating Autophagy

Ke X, Huang Y, Li L, Xin F, Xu L, Zhang Y, Zeng Z, Lin F, Song Y

Drug Design, Development and Therapy 2020, 14:2449-2460

Published Date: 23 June 2020

Artificial Neural Network (ANN) Approach to Predict an Optimized pH-Dependent Mesalamine Matrix Tablet

Khan AM, Hanif M, Bukhari NI, Shamim R, Rasool F, Rasul S, Shafique S

Drug Design, Development and Therapy 2020, 14:2435-2448

Published Date: 22 June 2020

Aprepitant Sensitizes Acute Myeloid Leukemia Cells to the Cytotoxic Effects of Cytosine Arabinoside in vitro and in vivo

Wu H, Cheng X, Huang F, Shao G, Meng Y, Wang L, Wang T, Jia X, Yang T, Wang X, Fu C

Drug Design, Development and Therapy 2020, 14:2413-2422

Published Date: 18 June 2020

Sugar Codes Conjugated Alginate: An Innovative Platform to Make a Strategic Breakthrough in Simultaneous Prophylaxis of GERD and Helicobacter pylori Infection

Moayedi S, Yadegar A, Balalaie S, Yarmohammadi M, Zali MR, Suzuki H, Fricker G, Haririan I

Drug Design, Development and Therapy 2020, 14:2405-2412

Published Date: 17 June 2020

Metformin Decreases Insulin Resistance in Type 1 Diabetes Through Regulating p53 and RAP2A in vitro and in vivo

Ren GF, Xiao LL, Ma XJ, Yan YS, Jiao PF

Drug Design, Development and Therapy 2020, 14:2381-2392

Published Date: 17 June 2020

Activation of GPR40 Suppresses AGE-Induced Reduction of Type II Collagen and Aggrecan in Human SW1353 Chondrocytes

Gu J, Lin H, Zhang Y, Xu T, Wang T, Xue X, Zhang W, Liu H

Drug Design, Development and Therapy 2020, 14:2371-2379

Published Date: 15 June 2020

A Gastric Cancer Peptide GX1-Modified Nano-Lipid Carriers Encapsulating Paclitaxel: Design and Evaluation of Anti-Tumor Activity

Jian Y, Zhao M, Cao J, Fan T, Bu W, Yang Y, Li W, Zhang W, Qiao Y, Wang J, Wen A

Drug Design, Development and Therapy 2020, 14:2355-2370

Published Date: 12 June 2020

In vitro and in vivo Anti-Tumor Effects of Pan-HER Inhibitor Varlitinib on Cholangiocarcinoma Cell Lines

Dokduang H, Jamnongkarn W, Promraksa B, Suksawat M, Padthaisong S, Thanee M, Phetcharaburanin J, Namwat N, Sangkhamanon S, Titapun A, Khuntikeo N, Klanrit P, Loilome W

Drug Design, Development and Therapy 2020, 14:2319-2334

Published Date: 11 June 2020

Scalable in silico Simulation of Transdermal Drug Permeability: Application of BIOiSIM Platform

Maharao N, Antontsev V, Hou H, Walsh J, Varshney J

Drug Design, Development and Therapy 2020, 14:2307-2317

Published Date: 11 June 2020

Nimodipine Improves Cognitive Impairment After Subarachnoid Hemorrhage in Rats Through IncRNA NEAT1/miR-27a/MAPT Axis

Li JW, Ren SH, Ren JR, Zhen ZG, Li LR, Hao XD, Ji HM

Drug Design, Development and Therapy 2020, 14:2295-2306

Published Date: 10 June 2020

Combination Therapy of Lung Cancer Using Layer-by-Layer Cisplatin Prodrug and Curcumin Co-Encapsulated Nanomedicine

Hong Y, Che S, Hui B, Wang X, Zhang X, Ma H

Drug Design, Development and Therapy 2020, 14:2263-2274

Published Date: 9 June 2020

Combination Chemotherapy of Lung Cancer – Co-Delivery of Docetaxel Prodrug and Cisplatin Using Aptamer-Decorated Lipid–Polymer Hybrid Nanoparticles

Wu R, Zhang Z, Wang B, Chen G, Zhang Y, Deng H, Tang Z, Mao J, Wang L

Drug Design, Development and Therapy 2020, 14:2249-2261

Published Date: 9 June 2020

Parenteral Sustained Release Lipid Phase-Transition System of Ziprasidone: Fabrication and Evaluation for Schizophrenia Therapy

Khan UA, Parveen U, Hasan N, Ahmed MZ, Saad S, Ahmad FJ, Jain GK

Drug Design, Development and Therapy 2020, 14:2237-2247

Published Date: 9 June 2020

Treatment with a PPAR-γ Agonist Protects Against Hyperuricemic Nephropathy in a Rat Model

Wang X, Deng J, Xiong C, Chen H, Zhou Q, Xia Y, Shao X, Zou H

Drug Design, Development and Therapy 2020, 14:2221-2233

Published Date: 8 June 2020

Gastro-Protective Effects of Calycosin Against Precancerous Lesions of Gastric Carcinoma in Rats

Li D, Zhao L, Li Y, Kang X, Zhang S

Drug Design, Development and Therapy 2020, 14:2207-2219

Published Date: 9 June 2020

Effects of Voriconazole on the Pharmacokinetics of Vonoprazan in Rats

Shen J, Wang B, Wang S, Chen F, Meng D, Jiang H, Zhou Y, Geng P, Zhou Q, Liu B

Drug Design, Development and Therapy 2020, 14:2199-2206

Published Date: 4 June 2020

Development of 13-Cys-BBR as an Agent Having Dual Action of Anti-Thrombosis and Anti-Inflammation

Li G, Wang T, Zhang X, Zhao S, Wang Y, Wu J, Peng S, Zhao M

Drug Design, Development and Therapy 2020, 14:2187-2197

Published Date: 3 June 2020

Comparative Cholinesterase, α-Glucosidase Inhibitory, Antioxidant, Molecular Docking, and Kinetic Studies on Potent Succinimide Derivatives

Ahmad A, Ullah F, Sadiq A, Ayaz M, Saeed Jan M, Shahid M, Wadood A, Mahmood F, Rashid U, Ullah R, Sahibzada MUK, Alqahtani AS, Mahmood HM

Drug Design, Development and Therapy 2020, 14:2165-2178

Published Date: 3 June 2020

Analysis of Renal and Cardiac Outcomes in Male Participants in the Fabry Outcome Survey Starting Agalsidase Alfa Enzyme Replacement Therapy Before and After 18 Years of Age

Parini R, Pintos-Morell G, Hennermann JB, Hsu TR, Karabul N, Kalampoki V, Gurevich A, Ramaswami U

Drug Design, Development and Therapy 2020, 14:2149-2158

Published Date: 3 June 2020

Network Pharmacology and Experimental Evidence Reveal Dioscin Suppresses Proliferation, Invasion, and EMT via AKT/GSK3b/mTOR Signaling in Lung Adenocarcinoma

Mao W, Yin H, Chen W, Zhao T, Wu S, Jin H, Du B, Tan Y, Zhang R, He Y

Drug Design, Development and Therapy 2020, 14:2135-2147

Published Date: 28 May 2020

Effect of Lactoferrin Protein on Red Blood Cells and Macrophages: Mechanism of Parasite–Host Interaction [Corrigendum]

Anand N, Kanwar R, Dubey M, Vahishta RK, Sehgal R, Verma A, Kanwar J

Drug Design, Development and Therapy 2020, 14:2123-2124

Published Date: 28 May 2020

A Pharmacokinetic Drug Interaction Between Fimasartan and Linagliptin in Healthy Volunteers

Kang WY, Lee HW, Gwon MR, Cho S, Shim WS, Lee KT, Yang DH, Seong SJ, Yoon YR

Drug Design, Development and Therapy 2020, 14:2101-2111

Published Date: 26 May 2020

Dihydroartemisinin Inhibits the Proliferation of Leukemia Cells K562 by Suppressing PKM2 and GLUT1 Mediated Aerobic Glycolysis

Gao P, Shen S, Li X, Liu D, Meng Y, Liu Y, Zhu Y, Zhang J, Luo P, Gu L

Drug Design, Development and Therapy 2020, 14:2091-2100

Published Date: 27 May 2020

Resveratrol Exerts Anti-Osteoarthritic Effect by Inhibiting TLR4/NF-κB Signaling Pathway via the TLR4/Akt/FoxO1 Axis in IL-1β-Stimulated SW1353 Cells

Xu X, Liu X, Yang Y, He J, Jiang M, Huang Y, Liu X, Liu L, Gu H

Drug Design, Development and Therapy 2020, 14:2079-2090

Published Date: 26 May 2020

Synthesis and Biological Activity of Piperine Derivatives as Potential PPARγ Agonists

Wang Y, Yao Y, Liu J, Wu L, Liu T, Cui J, Lee DYW

Drug Design, Development and Therapy 2020, 14:2069-2078

Published Date: 26 May 2020

Glycine Improves Ischemic Stroke Through miR-19a-3p/AMPK/GSK-3β/HO-1 Pathway

Chen ZJ, Zhao XS, Fan TP, Qi HX, Li D

Drug Design, Development and Therapy 2020, 14:2021-2031

Published Date: 25 May 2020

A Triple Combination of Metformin, Acetylsalicylic Acid, and Oseltamivir Phosphate Impacts Tumour Spheroid Viability and Upends Chemoresistance in Triple-Negative Breast Cancer

Sambi M, Samuel V, Qorri B, Haq S, Burov SV, Markvicheva E, Harless W, Szewczuk MR

Drug Design, Development and Therapy 2020, 14:1995-2019

Published Date: 25 May 2020

Effects of Apatinib on the Pharmacokinetics of Nifedipine and Warfarin in Patients with Advanced Solid Tumors

Zhu YT, Teng Z, Zhang YF, Li W, Guo LX, Liu YP, Qu XJ, Wang QR, Mao SY, Chen XY, Zhong DF

Drug Design, Development and Therapy 2020, 14:1963-1970

Published Date: 20 May 2020

Alleviation of Liver Dysfunction, Oxidative Stress and Inflammation Underlies the Protective Effect of Ferulic Acid in Methotrexate-Induced Hepatotoxicity

Roghani M, Kalantari H, Khodayar MJ, Khorsandi L, Kalantar M, Goudarzi M, Kalantar H

Drug Design, Development and Therapy 2020, 14:1933-1941

Published Date: 20 May 2020

Inhibitory Effect of Lygodium Root on the Cytochrome P450 3A Enzyme in vitro and in vivo

Zhou Y, Hua A, Zhou Q, Geng P, Chen F, Yan L, Wang S, Wen C

Drug Design, Development and Therapy 2020, 14:1909-1919

Published Date: 19 May 2020

Applying Different Techniques to Improve the Bioavailability of Candesartan Cilexetil Antihypertensive Drug

Aly UF, Sarhan HA, Ali TFS, Sharkawy HAEB

Drug Design, Development and Therapy 2020, 14:1851-1865

Published Date: 14 May 2020

Pharmacokinetics and Metabolism Research of Shenkang Injection in Rats Based on UHPLC-MS/MS and UHPLC-Q-Orbitrap HRMS

Jiang X, Zhou L, Zuo L, Wang X, Shi Y, Du X, Zhang J, Liu L, Li Z, Xue L, Liu X, Sun Z

Drug Design, Development and Therapy 2020, 14:1837-1850

Published Date: 13 May 2020

Berberine Induces Autophagic Cell Death in Acute Lymphoblastic Leukemia by Inactivating AKT/mTORC1 Signaling

Liu J, Liu P, Xu T, Chen Z, Kong H, Chu W, Wang Y, Liu Y

Drug Design, Development and Therapy 2020, 14:1813-1823

Published Date: 12 May 2020

Pranlukast Antagonizes CD49f and Reduces Stemness in Triple-Negative Breast Cancer Cells

Velázquez-Quesada I, Ruiz-Moreno AJ, Casique-Aguirre D, Aguirre-Alvarado C, Cortés-Mendoza F, de la Fuente-Granada M, García-Pérez C, Pérez-Tapia SM, González-Arenas A, Segura-Cabrera A, Velasco-Velázquez MA

Drug Design, Development and Therapy 2020, 14:1799-1811

Published Date: 12 May 2020

Virtual Screening and Optimization of Novel mTOR Inhibitors for Radiosensitization of Hepatocellular Carcinoma

Feng YQ, Gu SX, Chen YS, Gao XD, Ren YX, Chen JC, Lu YY, Zhang H, Cao S

Drug Design, Development and Therapy 2020, 14:1779-1798

Published Date: 8 May 2020

Investigation of the Inhibitory Effect of Simvastatin on the Metabolism of Lidocaine Both in vitro and in vivo

Wang Y, Ou-yang Q, Huang W, Huang H, Zhuang X, Lin Q, Zeng D

Drug Design, Development and Therapy 2020, 14:1739-1747

Published Date: 6 May 2020

Pharmacokinetic Evaluation by Modeling and Simulation Analysis of a Donepezil Patch Formulation in Healthy Male Volunteers

Yoon SK, Bae KS, Hong DH, Kim SS, Choi YK, Lim HS

Drug Design, Development and Therapy 2020, 14:1729-1737

Published Date: 5 May 2020

High ACTN1 Is Associated with Poor Prognosis, and ACTN1 Silencing Suppresses Cell Proliferation and Metastasis in Oral Squamous Cell Carcinoma

Xie G, Zhao L, Chen Q, Tang D, Chen Q, Lu H, Cai J, Chen Z

Drug Design, Development and Therapy 2020, 14:1717-1727

Published Date: 5 May 2020

Pexidartinib, a Novel Small Molecule CSF-1R Inhibitor in Use for Tenosynovial Giant Cell Tumor: A Systematic Review of Pre-Clinical and Clinical Development

Benner B, Good L, Quiroga D, Schultz TE, Kassem M, Carson WE, Cherian MA, Sardesai S, Wesolowski R

Drug Design, Development and Therapy 2020, 14:1693-1704

Published Date: 4 May 2020

Pharmacokinetic-Based Drug–Drug Interactions with Anaplastic Lymphoma Kinase Inhibitors: A Review

Zhao D, Chen J, Chu M, Long X, Wang J

Drug Design, Development and Therapy 2020, 14:1663-1681

Published Date: 30 April 2020

Astaxanthin Attenuates Neuroinflammation in Status Epilepticus Rats by Regulating the ATP-P2X7R Signal

Wang M, Deng X, Xie Y, Chen Y

Drug Design, Development and Therapy 2020, 14:1651-1662

Published Date: 30 April 2020

Arsenic Disulfide Promoted Hypomethylation by Increasing DNA Methyltransferases Expression in Myelodysplastic Syndrome

Zhou QB, Liu ZT, Wang HZ, Guo XQ, Xu YG, Hu XM

Drug Design, Development and Therapy 2020, 14:1641-1650

Published Date: 30 April 2020

Effect of Eriodictyol on Collagen-Induced Arthritis in Rats by Akt/HIF-1α Pathway

Lei Z, Ouyang L, Gong Y, Wang Z, Yu B

Drug Design, Development and Therapy 2020, 14:1633-1639

Published Date: 29 April 2020

Bone Marrow Mesenchymal Stem Cell-Derived Exosomes Improves Spinal Cord Function After Injury in Rats by Activating Autophagy

Gu J, Jin ZS, Wang CM, Yan XF, Mao YQ, Chen S

Drug Design, Development and Therapy 2020, 14:1621-1631

Published Date: 29 April 2020

In vitro Multistage Malaria Transmission Blocking Activity of Selected Malaria Box Compounds

Malebo HM, D'Alessandro S, Ebstie YA, Sorè H, Tenoh Guedoung AR, Katani SJ, Parapini S, Taramelli D, Habluetzel A

Drug Design, Development and Therapy 2020, 14:1593-1607

Published Date: 28 April 2020

Metformin Inhibits Propofol-Induced Apoptosis of Mouse Hippocampal Neurons HT-22 Through Downregulating Cav-1

Ge J, Huang Y, Zhang Y, Liu L, Gu T, Liu X, Yao L, Cai M, Sun J, Song J

Drug Design, Development and Therapy 2020, 14:1561-1569

Published Date: 21 April 2020

ACE2 Attenuates Epithelial-Mesenchymal Transition in MLE-12 Cells Induced by Silica

Li S, Li Y, Xu H, Wei Z, Yang Y, Jin F, Zhang M, Wang C, Song W, Huo J, Zhao J, Yang X, Yang F

Drug Design, Development and Therapy 2020, 14:1547-1559

Published Date: 21 April 2020

Selection and Characterization of a Novel DNA Aptamer, Apt-07S Specific to Hepatocellular Carcinoma Cells

Yu XX, Ge KL, Liu N, Zhang JY, Xue ML, Ge YL

Drug Design, Development and Therapy 2020, 14:1535-1545

Published Date: 20 April 2020

Optimal Approach and Strategies to Strengthen Pharmacovigilance in Sub-Saharan Africa: A Cohort Study of Patients Treated with First-Line Artemisinin-Based Combination Therapies in the Nanoro Health and Demographic Surveillance System, Burkina Faso

Rouamba T, Sondo P, Derra K, Nakanabo-Diallo S, Bihoun B, Rouamba E, Tarnagda Z, Kazienga A, Valea I, Sorgho H, Pagnoni F, Samadoulougou-Kirakoya F, Tinto H

Drug Design, Development and Therapy 2020, 14:1507-1521

Published Date: 16 April 2020

Isoliquiritigenin Attenuates UUO-Induced Renal Inflammation and Fibrosis by Inhibiting Mincle/Syk/NF-Kappa B Signaling Pathway

Liao Y, Tan R, Li J, Liu T, Zhong X, Yan Y, Yang J, Lin X, Fan J, Wang L

Drug Design, Development and Therapy 2020, 14:1455-1468

Published Date: 14 April 2020

Salidroside Alleviates Cartilage Degeneration Through NF-κB Pathway in Osteoarthritis Rats

Gao H, Peng L, Li C, Ji Q, Li P

Drug Design, Development and Therapy 2020, 14:1445-1454

Published Date: 14 April 2020

Metabolite Profiling in Anticancer Drug Development: A Systematic Review

Muhamad N, Na-Bangchang K

Drug Design, Development and Therapy 2020, 14:1401-1444

Published Date: 9 April 2020

One-Pot Synthesis of Novel Thiazoles as Potential Anti-Cancer Agents

Sayed AR, Gomha SM, Taher EA, Muhammad ZA, El-Seedi HR, Gaber HM, Ahmed MM

Drug Design, Development and Therapy 2020, 14:1363-1375

Published Date: 3 April 2020

Proniosomal Telmisartan Tablets: Formulation, in vitro Evaluation and in vivo Comparative Pharmacokinetic Study in Rabbits

Teaima MH, Yasser M, El-Nabarawi MA, Helal DA

Drug Design, Development and Therapy 2020, 14:1319-1331

Published Date: 31 March 2020

Leishmania donovani Growth Inhibitors from Pathogen Box Compounds of Medicine for Malaria Venture

Tadele M, Abay SM, Makonnen E, Hailu A

Drug Design, Development and Therapy 2020, 14:1307-1317

Published Date: 31 March 2020

Alginate Suppresses Liver Fibrosis Through the Inhibition of Nuclear Factor-κB Signaling

Xia Z, Ding L, Zheng J, Xu Y, Jin W, Sheng X, Wu J

Drug Design, Development and Therapy 2020, 14:1295-1305

Published Date: 31 March 2020

Diterpene Ginkgolides Exert an Antidepressant Effect Through the NT3-TrkA and Ras-MAPK Pathways

Wang T, Bai S, Wang W, Chen Z, Chen J, Liang Z, Qi X, Shen H, Xie P

Drug Design, Development and Therapy 2020, 14:1279-1294

Published Date: 31 March 2020

Growth Factor Gene-Modified Mesenchymal Stem Cells in Tissue Regeneration

Nie WB, Zhang D, Wang LS

Drug Design, Development and Therapy 2020, 14:1241-1256

Published Date: 26 March 2020

Morusin Ameliorates IL-1β-Induced Chondrocyte Inflammation and Osteoarthritis via NF-κB Signal Pathway

Jia Y, He W, Zhang H, He L, Wang Y, Zhang T, Peng J, Sun P, Qian Y

Drug Design, Development and Therapy 2020, 14:1227-1240

Published Date: 26 March 2020

Comparison of Pharmacokinetics of Aprepitant in Healthy Chinese and Caucasian Subjects

Yang MJ, Xu HR, Li H, Chen WL, Yuan F, Li XN

Drug Design, Development and Therapy 2020, 14:1219-1226

Published Date: 24 March 2020

Miconazole Contributes to NRF2 Activation by Noncanonical P62-KEAP1 Pathway in Bladder Cancer Cells

Tsai TF, Chen PC, Lin YC, Chou KY, Chen HE, Ho CY, Lin JF, Hwang TIS

Drug Design, Development and Therapy 2020, 14:1209-1218

Published Date: 24 March 2020

Paeoniflorin Ameliorates Chronic Hypoxia/SU5416-Induced Pulmonary Arterial Hypertension by Inhibiting Endothelial-to-Mesenchymal Transition

Yu M, Peng L, Liu P, Yang M, Zhou H, Ding Y, Wang J, Huang W, Tan Q, Wang Y, Xie W, Kong H, Wang H

Drug Design, Development and Therapy 2020, 14:1191-1202

Published Date: 19 March 2020

A First-in-Human Dose Finding Study of Camrelizumab in Patients with Advanced or Metastatic Cancer in Australia

Lickliter JD, Gan HK, Voskoboynik M, Arulananda S, Gao B, Nagrial A, Grimison P, Harrison M, Zou J, Zhang L, Luo S, Lahn M, Kallender H, Mannucci A, Somma C, Woods K, Behren A, Fernandez-Penas P, Millward M, Meniawy T

Drug Design, Development and Therapy 2020, 14:1177-1189

Published Date: 18 March 2020

Hyaluronic Acid Capped, Irinotecan and Gene Co-Loaded Lipid-Polymer Hybrid Nanocarrier-Based Combination Therapy Platform for Colorectal Cancer

Wang Z, Zang A, Wei Y, An L, Hong D, Shi Y, Zhang J, Su S, Fang G

Drug Design, Development and Therapy 2020, 14:1095-1105

Published Date: 12 March 2020

Review on the Structures and Activities of Transthyretin Amyloidogenesis Inhibitors

Guo X, Liu Z, Zheng Y, Li Y, Li L, Liu H, Chen Z, Wu L

Drug Design, Development and Therapy 2020, 14:1057-1081

Published Date: 10 March 2020

KLF6 Induces Apoptosis in Human Lens Epithelial Cells Through the ATF4-ATF3-CHOP Axis

Tian F, Zhao J, Bu S, Teng H, Yang J, Zhang X, Li X, Dong L

Drug Design, Development and Therapy 2020, 14:1041-1055

Published Date: 9 March 2020

In silico Design and Synthesis of Tetrahydropyrimidinones and Tetrahydropyrimidinethiones as Potential Thymidylate Kinase Inhibitors Exerting Anti-TB Activity Against Mycobacterium tuberculosis

Venugopala KN, Tratrat C, Pillay M, Chandrashekharappa S, Al-Attraqchi OHA, Aldhubiab BE, Attimarad M, Alwassil OI, Nair AB, Sreeharsha N, Venugopala R, Morsy MA, Haroun M, Kumalo HM, Odhav B, Mlisana K

Drug Design, Development and Therapy 2020, 14:1027-1039

Published Date: 9 March 2020

Characterization and Evaluation of Antioxidant Activity of Aloe schelpei Reynolds

Teka T, Kassahun H

Drug Design, Development and Therapy 2020, 14:1003-1008

Published Date: 5 March 2020

Bisdemethoxycurcumin Inhibits Hepatocellular Carcinoma Proliferation Through Akt Inactivation via CYLD-Mediated Deubiquitination

Qiu C, Liu K, Zhang S, Gao S, Chen W, Li D, Huang Y

Drug Design, Development and Therapy 2020, 14:993-1001

Published Date: 5 March 2020

Study on the Formation of Antihypertensive Twin Drugs by Caffeic Acid and Ferulic Acid with Telmisartan

Li P, Peng Y, Ma Q, Li Z, Zhang X

Drug Design, Development and Therapy 2020, 14:977-992

Published Date: 5 March 2020

Perindopril in Breast Milk and Determination of Breastfed Infant Exposure: A Prospective Observational Study

Leggett C, Lwin EMP, Ritchie U, Song Y, Gerber JP, Turner S, Hague WM, Stark M, Upton R, Garg S

Drug Design, Development and Therapy 2020, 14:961-967

Published Date: 2 March 2020

Finasteride and Its Potential for the Treatment of Female Pattern Hair Loss: Evidence to Date

Iamsumang W, Leerunyakul K, Suchonwanit P

Drug Design, Development and Therapy 2020, 14:951-959

Published Date: 2 March 2020

The Traditional Chinese Medicine Compound, GRS, Alleviates Blood–Brain Barrier Dysfunction

Zhang Y, Hu Y, Li M, Wang J, Guo G, Li F, Yu B, Kou J

Drug Design, Development and Therapy 2020, 14:933-947

Published Date: 28 February 2020

Oxymatrine Liposomes for Intervertebral Disc Treatment: Formulation, in vitro and vivo Assessments

Wang H, Ding Y, Zhang W, Wei K, Pei Y, Zou C, Zhang C, Ding J, Fang H, Tan S

Drug Design, Development and Therapy 2020, 14:921-931

Published Date: 28 February 2020

Pleiotropic Anticancer Properties of Scorpion Venom Peptides: Rhopalurus princeps Venom as an Anticancer Agent

Mikaelian AG, Traboulay E, Zhang XM, Yeritsyan E, Pedersen PL, Ko YH, Matalka KZ

Drug Design, Development and Therapy 2020, 14:881-893

Published Date: 27 February 2020

The Advantages of Levodopa-Carbidopa Intestinal Gel for Patients with Advanced Parkinson’s Disease: A Systematic Review

Zhang XR, Jiang ZY, Zhang ZR, Chen HJ, Wu K, He JC, Xie CL

Drug Design, Development and Therapy 2020, 14:845-854

Published Date: 26 February 2020

Metalloprotoporphyrin Inhibition of HCV NS3-4A Protease: Structure–Activity Relationships

Hu K, Zhu Z, Mathahs MM, Tran H, Bommer J, Testa CA, Schmidt WN

Drug Design, Development and Therapy 2020, 14:757-771

Published Date: 24 February 2020

NVP-BSK805, an Inhibitor of JAK2 Kinase, Significantly Enhances the Radiosensitivity of Esophageal Squamous Cell Carcinoma in vitro and in vivo

Hua Y, Wang W, Zheng X, Yang L, Wu H, Hu Z, Li Y, Yue J, Jiang Z, Zhang X, Hou Q, Wu S

Drug Design, Development and Therapy 2020, 14:745-755

Published Date: 24 February 2020

Synthesis, Characterization, and Pharmacodynamics Study of Enrofloxacin Mesylate

Pei L, Yang W, Fu J, Liu M, Zhang T, Li D, Huang R, Zhang L, Peng G, Shu G, Yuan Z, Lin J, Zhang W, Zhong Z, Zhao L, Fu H

Drug Design, Development and Therapy 2020, 14:715-730

Published Date: 24 February 2020

Anti-Inflammatory Activity of Sanjie Zhentong Capsule Assessed By Network Pharmacology Analysis of Adenomyosis Treatment 

Du L, Du DH, Chen B, Ding Y, Zhang T, Xiao W

Drug Design, Development and Therapy 2020, 14:697-713

Published Date: 20 February 2020

Colon Targeting of Naringin for Enhanced Cytoprotection Against Indomethacin-Induced Colitis in Rabbits

El Naggar EE, Mohamed EA, Borg TM, El-Sheakh AR, Hamed MF

Drug Design, Development and Therapy 2020, 14:677-696

Published Date: 19 February 2020

Impacts of CYP2C19 Polymorphism and Clopidogrel Dosing on in-Stent Restenosis: A Retrospective Cohort Study in Chinese Patients

Zhang M, Wang J, Zhang Y, Zhang P, Jia Z, Ren M, Jia X, Ma L, Gao M, Hou Y

Drug Design, Development and Therapy 2020, 14:669-676

Published Date: 19 February 2020

A Comparative Study of Inhaled Nitric Oxide and an Intravenously Administered Nitric Oxide Donor in Acute Pulmonary Hypertension

Stene Hurtsén A, Zorikhin Nilsson I, Dogan EM, Nilsson KF

Drug Design, Development and Therapy 2020, 14:635-645

Published Date: 17 February 2020

Hydrogen Sulfide Protects Against High Glucose-Induced Human Umbilical Vein Endothelial Cell Injury Through Activating PI3K/Akt/eNOS Pathway

Lin F, Yang Y, Wei S, Huang X, Peng Z, Ke X, Zeng Z, Song Y

Drug Design, Development and Therapy 2020, 14:621-633

Published Date: 14 February 2020

Pharmacokinetics and Tolerability of Single and Multiple Intravenous Doses of Cefotetan Disodium in Healthy Chinese Volunteers

Liu J, Zhai Y, Wu L, Wu G, Zheng Y, Hu X, Shentu J

Drug Design, Development and Therapy 2020, 14:613-620

Published Date: 13 February 2020

Silibinin Augments the Antifibrotic Effect of Valsartan Through Inactivation of TGF-β1 Signaling in Kidney

Liu R, Wang Q, Ding Z, Zhang X, Li Y, Zang Y, Zhang G

Drug Design, Development and Therapy 2020, 14:603-611

Published Date: 13 February 2020

Lysosomal Acid Lipase Deficiency: Therapeutic Options

Pastores GM, Hughes DA

Drug Design, Development and Therapy 2020, 14:591-601

Published Date: 11 February 2020

Regulations of miR-183-5p and Snail-Mediated Shikonin-Reduced Epithelial-Mesenchymal Transition in Cervical Cancer Cells

Tang Q, Liu L, Zhang H, Xiao J, Hann SS

Drug Design, Development and Therapy 2020, 14:577-589

Published Date: 11 February 2020

Minoxidil and Its Use in Hair Disorders: A Review [Corrigendum]

Suchonwanit P, Thammarucha S, Leerunyakul K

Drug Design, Development and Therapy 2020, 14:575-576

Published Date: 10 February 2020

Optimization of a Benzothiazole Indolene Scaffold Targeting Bacterial Cell Wall Assembly

Chauhan J, Yu W, Cardinale S, Opperman TJ, MacKerell AD Jr, Fletcher S, de Leeuw EPH

Drug Design, Development and Therapy 2020, 14:567-574

Published Date: 10 February 2020

Focus on Notoginsenoside R1 in Metabolism and Prevention Against Human Diseases

Liu H, Yang J, Yang W, Hu S, Wu Y, Zhao B, Hu H, Du S

Drug Design, Development and Therapy 2020, 14:551-565

Published Date: 7 February 2020

Potential Use of Microbial Surfactant in Microemulsion Drug Delivery System: A Systematic Review

Ohadi M, Shahravan A, Dehghannoudeh N, Eslaminejad T, Banat IM, Dehghannoudeh G

Drug Design, Development and Therapy 2020, 14:541-550

Published Date: 5 February 2020

In silico Analysis, Molecular Docking, Molecular Dynamic, Cloning, Expression and Purification of Chimeric Protein in Colorectal Cancer Treatment [Erratum]

Dana H, Mahmoodi Chalbatani G, Gharagouzloo E, Miri SR, Memari F, Rasoolzadeh R, Zinatizadeh MR, Kheirandish Zarandi P, Marmari V

Drug Design, Development and Therapy 2020, 14:539-540

Published Date: 5 February 2020

Panax Notoginseng Ameliorates Podocyte EMT by Targeting the Wnt/β-Catenin Signaling Pathway in STZ-Induced Diabetic Rats

Xie L, Zhai R, Chen T, Gao C, Xue R, Wang N, Wang J, Xu Y, Gui D

Drug Design, Development and Therapy 2020, 14:527-538

Published Date: 5 February 2020

Design, Synthesis and Biological Evaluation of New HDAC1 and HDAC2 Inhibitors Endowed with Ligustrazine as a Novel Cap Moiety

Al-Sanea MM, Gotina L, Mohamed MFA, Grace Thomas Parambi D, Gomaa HAM, Mathew B, Youssif BGM, Alharbi KS, Elsayed ZM, Abdelgawad MA, Eldehna WM

Drug Design, Development and Therapy 2020, 14:497-508

Published Date: 4 February 2020

New Isatin–Indole Conjugates: Synthesis, Characterization, and a Plausible Mechanism of Their in vitro Antiproliferative Activity

Al-Wabli RI, Almomen AA, Almutairi MS, Keeton AB, Piazza GA, Attia MI

Drug Design, Development and Therapy 2020, 14:483-495

Published Date: 3 February 2020

Metformin Activates the AMPK-mTOR Pathway by Modulating lncRNA TUG1 to Induce Autophagy and Inhibit Atherosclerosis

You G, Long X, Song F, Huang J, Tian M, Xiao Y, Deng S, Wu Q

Drug Design, Development and Therapy 2020, 14:457-468

Published Date: 3 February 2020

Development of a Novel Controlled-Release Tablet of Pregabalin: Formulation Variation and Pharmacokinetics in Dogs and Humans

Kim KH, Lim SH, Shim CR, Park J, Song WH, Kwon MC, Lee JH, Park JS, Choi HG

Drug Design, Development and Therapy 2020, 14:445-456

Published Date: 30 January 2020

Calycosin Influences the Metabolism of Five Probe Drugs in Rats

Wu M, Lin Y, Wei Y, Du H, Ying X, Tan W, Tang B

Drug Design, Development and Therapy 2020, 14:429-434

Published Date: 29 January 2020

A New Validated HPLC-MS/MS Method for Quantification and Pharmacokinetic Evaluation of Dovitinib, a Multi-Kinase Inhibitor, in Mouse Plasma

AlRabiah H, Kadi AA, Aljohar HI, Attwa MW, Al-Shakliah NS, Attia SM, Mostafa GAE

Drug Design, Development and Therapy 2020, 14:407-415

Published Date: 28 January 2020

Reversible Small Molecule Inhibitors of MAO A and MAO B with Anilide Motifs

Hagenow J, Hagenow S, Grau K, Khanfar M, Hefke L, Proschak E, Stark H

Drug Design, Development and Therapy 2020, 14:371-393

Published Date: 28 January 2020

In silico Analysis, Molecular Docking, Molecular Dynamic, Cloning, Expression and Purification of Chimeric Protein in Colorectal Cancer Treatment

Dana H, Mahmoodi Chalbatani G, Gharagouzloo E, Miri SR, Memari F, Rasoolzadeh R, Zinatizadeh MR, Kheirandish Zarandi P, Marmari V

Drug Design, Development and Therapy 2020, 14:309-329

Published Date: 23 January 2020

Progress in Understanding the Molecular Mechanisms Underlying the Antitumour Effects of Ivermectin

Liu J, Zhang K, Cheng L, Zhu H, Xu T

Drug Design, Development and Therapy 2020, 14:285-296

Published Date: 21 January 2020

Apatinib in Patients with Relapsed or Refractory Diffuse Large B Cell Lymphoma: A Phase II, Open-Label, Single-Arm, Prospective Study

Ma X, Li L, Zhang L, Fu X, Li X, Wang X, Wu J, Sun Z, Zhang X, Feng X, Chang Y, Zhou Z, Nan F, Zhang J, Li Z, Zhang M

Drug Design, Development and Therapy 2020, 14:275-284

Published Date: 22 January 2020

The Impact of Loading Dose on Outcome in Stroke Patients Receiving Low-Dose Tissue Plasminogen Activator Thrombolytic Therapy

Wong YS, Sung SF, Wu CS, Hsu YC, Su YH, Hung LC, Ong CT

Drug Design, Development and Therapy 2020, 14:257-263

Published Date: 17 January 2020

Enhancing Betulinic Acid Dissolution Rate and Improving Antitumor Activity via Nanosuspension Constructed by Anti-Solvent Technique

Li S, Zhang J, Fang Y, Yi J, Lu Z, Chen Y, Guo B

Drug Design, Development and Therapy 2020, 14:243-256

Published Date: 16 January 2020

Electrospun PLA Fibers Containing Metronidazole for Periodontal Disease

Budai-Szűcs M, Léber A, Cui L, Józó M, Vályi P, Burián K, Kirschweng B, Csányi E, Pukánszky B

Drug Design, Development and Therapy 2020, 14:233-242

Published Date: 16 January 2020

Discovery of a Novel Benzenesulfonamide Analogue That Inhibits Proliferation and Metastasis Against Ovarian Cancer OVCAR-8 Cells

Jia Y, Li M, Cao Y, Feng W, Li X, Xue W, Shi H

Drug Design, Development and Therapy 2020, 14:207-216

Published Date: 15 January 2020

Baicalin Ameliorates Dexamethasone-Induced Osteoporosis by Regulation of the RANK/RANKL/OPG Signaling Pathway

Zhao Y, Wang HL, Li TT, Yang F, Tzeng CM

Drug Design, Development and Therapy 2020, 14:195-206

Published Date: 15 January 2020

Curcumin Combined with Thalidomide Reduces Expression of STAT3 and Bcl-xL, Leading to Apoptosis in Acute Myeloid Leukemia Cell Lines

Mohammadi Kian M, Salemi M, Bahadoran M, Haghi A, Dashti N, Mohammadi S, Rostami S, Chahardouli B, Babakhani D, Nikbakht M

Drug Design, Development and Therapy 2020, 14:185-194

Published Date: 15 January 2020

Isoborneol Attenuates Low-Density Lipoprotein Accumulation and Foam Cell Formation in Macrophages

Wang Y, Li Z, Liu B, Wu R, Gong H, Su Z, Zhang S

Drug Design, Development and Therapy 2020, 14:167-173

Published Date: 15 January 2020

Aloin Inhibits the Proliferation and Migration of Gastric Cancer Cells by Regulating NOX2–ROS-Mediated Pro-Survival Signal Pathways

Wang Z, Tang T, Wang S, Cai T, Tao H, Zhang Q, Qi S, Qi Z

Drug Design, Development and Therapy 2020, 14:145-155

Published Date: 14 January 2020

Metabolic Stability Assessment of Larotrectinib Using Liquid Chromatography Tandem Mass Spectrometry

Attwa MW, Kadi AA, Darwish HW

Drug Design, Development and Therapy 2020, 14:111-119

Published Date: 10 January 2020

Suitability of Amoxicillin–Clavulanic Acid for Administration via Prolonged Infusion

Fawaz S, Dixon B, Barton S, Mohamed A, Nabhani-Gebara S

Drug Design, Development and Therapy 2020, 14:103-109

Published Date: 10 January 2020

Curcumin Attenuates Oxaliplatin-Induced Liver Injury and Oxidative Stress by Activating the Nrf2 Pathway

Lu Y, Wu S, Xiang B, Li L, Lin Y

Drug Design, Development and Therapy 2020, 14:73-85

Published Date: 9 January 2020

Sappanone A Protects Against Myocardial Ischemia Reperfusion Injury by Modulation of Nrf2

Shi X, Tao G, Ji L, Tian G

Drug Design, Development and Therapy 2020, 14:61-71

Published Date: 8 January 2020

Engineering of Naproxen Loaded Polymer Hybrid Enteric Microspheres for Modified Release Tablets: Development, Characterization, in silico Modelling and in vivo Evaluation

Hameed HA, Khan S, Shahid M, Ullah R, Bari A, Ali SS, Hussain Z, Sohail M, Khan SU, Htar TT

Drug Design, Development and Therapy 2020, 14:27-41

Published Date: 7 January 2020

NMMHC IIA Inhibition Ameliorates Cerebral Ischemic/Reperfusion-Induced Neuronal Apoptosis Through Caspase-3/ROCK1/MLC Pathway

Wang GY, Wang TZ, Zhang YY, Li F, Yu BY, Kou JP

Drug Design, Development and Therapy 2020, 14:13-25

Published Date: 6 January 2020

Dexmedetomidine Promotes Hippocampal Neurogenesis and Improves Spatial Learning and Memory in Neonatal Rats

Zhang Y, Gao Q, Wu Z, Xue H, Liu B, Zhao P

Drug Design, Development and Therapy 2019, 13:4439-4449

Published Date: 3 January 2020

Developmental Pharmacogenetics of SLCO2B1 on Montelukast Pharmacokinetics in Chinese Children

Li Q, Wang K, Shi HY, Wu YE, Zhou Y, Kan M, Zheng Y, Hao GX, Yang XM, Yang YL, Su LQ, Wang XL, Jacqz-Aigrain E, Zhou J, Zhao W

Drug Design, Development and Therapy 2019, 13:4405-4411

Published Date: 27 December 2019

An Efficient, Lung-Targeted, Drug-Delivery System To Treat Asthma Via Microparticles

SreeHarsha N, Venugopala KN, Nair AB, Roopashree TS, Attimarad M, Hiremath JG, Al-Dhubiab BE, Ramnarayanan C, Shinu P, Handral M, Haroun M, Tratrat C

Drug Design, Development and Therapy 2019, 13:4389-4403

Published Date: 27 December 2019

Levonadifloxacin, a Novel Broad-Spectrum Anti-MRSA Benzoquinolizine Quinolone Agent: Review of Current Evidence

Bhagwat SS, Nandanwar M, Kansagara A, Patel A, Takalkar S, Chavan R, Periasamy H, Yeole R, Deshpande PK, Bhavsar S, Bhatia A, Ahdal J, Jain R, Patel M

Drug Design, Development and Therapy 2019, 13:4351-4365

Published Date: 24 December 2019

Memory Impairment Induced by Chronic Psychosocial Stress Is Prevented by L-Carnitine

Rababa'h SY, Alzoubi KH, Hammad HM, Alquraan L, El-Salem K

Drug Design, Development and Therapy 2019, 13:4341-4350

Published Date: 19 December 2019

Efficacy and Safety of Umbilical Cord Mesenchymal Stem Cell Therapy for Rheumatoid Arthritis Patients: A Prospective Phase I/II Study

Wang L, Huang S, Li S, Li M, Shi J, Bai W, Wang Q, Zheng L, Liu Y

Drug Design, Development and Therapy 2019, 13:4331-4340

Published Date: 19 December 2019

AR-42: A Pan-HDAC Inhibitor with Antitumor and Antiangiogenic Activities in Esophageal Squamous Cell Carcinoma

Zhu Y, Yuan T, Zhang Y, Shi J, Bai L, Duan X, Tong R, Zhong L

Drug Design, Development and Therapy 2019, 13:4321-4330

Published Date: 19 December 2019

A Novel Nanomicellar Combination of Fenretinide and Lenalidomide Shows Marked Antitumor Activity in a Neuroblastoma Xenograft Model

Orienti I, Nguyen F, Guan P, Kolla V, Calonghi N, Farruggia G, Chorny M, Brodeur GM

Drug Design, Development and Therapy 2019, 13:4305-4319

Published Date: 19 December 2019

The Protective Role of Tanshinone IIA in Silicosis Rat Model via TGF-β1/Smad Signaling Suppression, NOX4 Inhibition and Nrf2/ARE Signaling Activation

Feng F, Cheng P, Zhang H, Li N, Qi Y, Wang H, Wang Y, Wang W

Drug Design, Development and Therapy 2019, 13:4275-4290

Published Date: 18 December 2019

Valproic Acid Addresses Neuroendocrine Differentiation of LNCaP Cells and Maintains Cell Survival

Giordano F, Naimo GD, Nigro A, Romeo F, Paolì A, De Amicis F, Vivacqua A, Morelli C, Mauro L, Panno ML

Drug Design, Development and Therapy 2019, 13:4265-4274

Published Date: 18 December 2019

Small-Molecule Intervention At The Dimerization Interface Of Survivin By Novel Rigidized Scaffolds

Ibrahim TM, Ernst C, Lange A, Hennig S, Boeckler FM

Drug Design, Development and Therapy 2019, 13:4247-4263

Published Date: 18 December 2019

Synthesis of Novel Xanthone Analogues and Their Growth Inhibitory Activity Against Human Lung Cancer A549 Cells

Wu J, Dai J, Zhang Y, Wang J, Huang L, Ding H, Li T, Zhang Y, Mao J, Yu S

Drug Design, Development and Therapy 2019, 13:4239-4246

Published Date: 13 December 2019

Molecular Requirements for the Expression of Antiplatelet Effects by Synthetic Structural Optimized Analogues of the Anticancer Drugs Imatinib and Nilotinib

Pantazi D, Ntemou N, Brentas A, Alivertis D, Skobridis K, Tselepis AD

Drug Design, Development and Therapy 2019, 13:4225-4238

Published Date: 12 December 2019

The Effect of Glutamine Supplementation on Oxidative Stress and Matrix Metalloproteinase 2 and 9 After Exhaustive Exercise

Nemati A, Alipanah-Moghadam R, Molazadeh L, Naghizadeh Baghi A

Drug Design, Development and Therapy 2019, 13:4215-4223

Published Date: 11 December 2019

Drug–Drug Interactions Of Amiodarone And Quinidine On The Pharmacokinetics Of Eliglustat In Rats

Wang Q, Wang H, Zhong Y, Zhang Q

Drug Design, Development and Therapy 2019, 13:4207-4213

Published Date: 12 December 2019

In Silico, Cytotoxic and Antioxidant Potential of Novel Ester, 3-hydroxyoctyl -5- trans-docosenoate Isolated from Anchusa arvensis (L.) M.Bieb. Against HepG-2 Cancer Cells

Hussain S, Ullah F, Ayaz M, Ali Shah SA, Ali Shah AH, Shah SM, Wadood A, Aman W, Ullah R, Shahat AA, Nasr FA

Drug Design, Development and Therapy 2019, 13:4195-4205

Published Date: 10 December 2019

Pharmacological Evaluation of Aldehydic-Pyrrolidinedione Against HCT-116, MDA-MB231, NIH/3T3, MCF-7 Cancer Cell Lines, Antioxidant and Enzyme Inhibition Studies

Ahmad A, Ullah F, Sadiq A, Ayaz M, Rahim H, Rashid U, Ahmad S, Jan MS, Ullah R, Shahat AA, Mahmood HM

Drug Design, Development and Therapy 2019, 13:4185-4194

Published Date: 10 December 2019

Preparation of a Novel One-Armed Anti-c-Met Antibody with Antitumor Activity Against Hepatocellular Carcinoma

Yin Y, Guo J, Teng F, Yu L, Jiang Y, Xie K, Jiang M, Fang J

Drug Design, Development and Therapy 2019, 13:4173-4184

Published Date: 10 December 2019

Inhibition Of JNK Phosphorylation By Curcumin Analog C66 Protects LPS-Induced Acute Lung Injury

Xiao Z, Xu F, Zhu X, Bai B, Guo L, Liang G, Shan X, Zhang Y, Zhao Y, Zhang B

Drug Design, Development and Therapy 2019, 13:4161-4171

Published Date: 10 December 2019

A Novel Hybrid Compound LLP2A-Alendronate Accelerates Open Fracture Healing in a Rabbit Model [Corrigendum]

Wang Z, Zhao Y, Zhang D, Qi B, Xiao W, Hu X, Yu A

Drug Design, Development and Therapy 2019, 13:4159-4160

Published Date: 9 December 2019

Catalpol Enhances Neurogenesis And Inhibits Apoptosis Of New Neurons Via BDNF, But Not The BDNF/Trkb Pathway

Zhu HF, Shao Y, Qin L, Wang JH, Feng S, Jiang YB, Wan D

Drug Design, Development and Therapy 2019, 13:4145-4157

Published Date: 10 December 2019

Radioprotective Potential of Sulindac Sulfide to Prevent DNA Damage Due to Ionizing Radiation

Torabizadeh SA, Rezaeifar M, Jomehzadeh A, Nabizadeh Haghighi F, Ansari M

Drug Design, Development and Therapy 2019, 13:4127-4134

Published Date: 6 December 2019

Efficacy and Safety of Combined Vitrectomy with Intravitreal Dexamethasone Implant for Advanced Stage Epiretinal Membrane

Iovino C, Giannaccare G, Pellegrini M, Bernabei F, Braghiroli M, Caporossi T, Peiretti E

Drug Design, Development and Therapy 2019, 13:4107-4114

Published Date: 3 December 2019

Profile of Tofacitinib in the Treatment of Ulcerative Colitis: An Evidence-Based Review of Recent Data

Varyani F, Argyriou K, Phillips F, Tsakiridou E, Moran GW

Drug Design, Development and Therapy 2019, 13:4091-4105

Published Date: 2 December 2019

Liraglutide Improves Non-Alcoholic Fatty Liver Disease In Diabetic Mice By Modulating Inflammatory Signaling Pathways

Luo Y, Yang P, Li Z, Luo Y, Shen J, Li R, Zheng H, Liang Y, Xia N

Drug Design, Development and Therapy 2019, 13:4065-4074

Published Date: 2 December 2019

Delivery Of Curcumin Nanoliposomes Using Surface Modified With CD133 Aptamers For Prostate Cancer

Ma Q, Qian W, Tao W, Zhou Y, Xue B

Drug Design, Development and Therapy 2019, 13:4021-4033

Published Date: 28 November 2019

Transformation of Meloxicam Containing Nanosuspension into Surfactant-Free Solid Compositions to Increase the Product Stability and Drug Bioavailability for Rapid Analgesia

Bartos C, Ambrus R, Katona G, Sovány T, Gáspár R, Márki Á, Ducza E, Ivanov A, Tömösi F, Janáky T, Szabó-Révész P

Drug Design, Development and Therapy 2019, 13:4007-4020

Published Date: 28 November 2019

A Network Pharmacology-Based Strategy For Predicting Active Ingredients And Potential Targets Of LiuWei DiHuang Pill In Treating Type 2 Diabetes Mellitus

He D, Huang JH, Zhang ZY, Du Q, Peng WJ, Yu R, Zhang SF, Zhang SH, Qin YH

Drug Design, Development and Therapy 2019, 13:3989-4005

Published Date: 28 November 2019

Postconditioning Protection Against Myocardiocyte Anoxia/Reoxygenation Injury From Penehyclidine Hydrochloride

Ren JY, Lin DM, Wang CB, Yang YL, Wang ZQ, Cui BQ, Ma J

Drug Design, Development and Therapy 2019, 13:3977-3988

Published Date: 26 November 2019

Effects Of Triptolide On Tooth Movement And Root Resorption In Rats

Yang F, Wang XX, Ma D, Cui Q, Zheng DH, Liu XC, Zhang J

Drug Design, Development and Therapy 2019, 13:3963-3975

Published Date: 25 November 2019

Icariin Alleviates IL-1β-Induced Matrix Degradation By Activating The Nrf2/ARE Pathway In Human Chondrocytes

Zuo S, Zou W, Wu RM, Yang J, Fan JN, Zhao XK, Li HY

Drug Design, Development and Therapy 2019, 13:3949-3961

Published Date: 21 November 2019

Alteration of Amino Acid Profiling Influenced by the Active Ingredients of DanHong Injection After Prescription Optimization

Guo Z, Zhu Y, Xu W, Luo K, Xiao H, Wang Z

Drug Design, Development and Therapy 2019, 13:3939-3947

Published Date: 21 November 2019

Assessment Of Spanlastic Vesicles Of Zolmitriptan For Treating Migraine In Rats

El-Nabarawy NA, Teaima MH, Helal DA

Drug Design, Development and Therapy 2019, 13:3929-3937

Published Date: 21 November 2019

The Effects Of Sevoflurane On The Progression And Cisplatinum Sensitivity Of Cervical Cancer Cells

Xue F, Xu Y, Song Y, Zhang W, Li R, Zhu X

Drug Design, Development and Therapy 2019, 13:3919-3928

Published Date: 18 November 2019

Efficacy And Safety Of Apatinib Treatment In Platinum-Resistant Recurrent Epithelial Ovarian Cancer: A Real World Study

Zhang J, Li A, Jiang Q, Zheng F, Zhu H

Drug Design, Development and Therapy 2019, 13:3913-3918

Published Date: 15 November 2019

Hesperidin: A Therapeutic Agent For Obesity

Xiong H, Wang J, Ran Q, Lou G, Peng C, Gan Q, Hu J, Sun J, Yao R, Huang Q

Drug Design, Development and Therapy 2019, 13:3855-3866

Published Date: 12 November 2019

Safety, pharmacokinetics and pharmacodynamics of the selective glucocorticoid receptor modulator AZD7594, following inhalation in healthy Japanese volunteers

Prothon S, Wählby Hamrén U, Tehler U, Yoon E, Forsman H, Arfvidsson C, Aggarwal A, Chen Y

Drug Design, Development and Therapy 2019, 13:3845-3853

Published Date: 12 November 2019

Comparing The Efficacy Of An Anti-Human VEGF-A Neutralizing Antibody Versus Bevacizumab On A Laser-Induced Choroidal Neovascularization (CNV) Rhesus Monkey Model

Olvera-Montaño O, Baiza-Duran L, Quintana-Hau JD, Quiñonez-Alvarado MG, Zeng W, Gong L, Muñoz-Villegas P

Drug Design, Development and Therapy 2019, 13:3813-3821

Published Date: 4 November 2019

Smart Targeting To Improve Cancer Therapeutics

Morales-Cruz M, Delgado Y, Castillo B, Figueroa CM, Molina AM, Torres A, Milián M, Griebenow K

Drug Design, Development and Therapy 2019, 13:3753-3772

Published Date: 30 October 2019

Baseline Lymphopenia: A Predictor Of Poor Outcomes In HER2 positive Metastatic Breast Cancer Treated With Trastuzumab

Che YQ, Zhang Y, Wang D, Liu HY, Shen D, Luo Y

Drug Design, Development and Therapy 2019, 13:3727-3734

Published Date: 29 October 2019

miR- 26a Sensitizes Melanoma Cells To Dabrafenib Via Targeting HMGB1-Dependent Autophagy Pathways

Yu Y, Xiang N, Lin M, Huang JW, Zhang J, Cheng B, Ji C

Drug Design, Development and Therapy 2019, 13:3717-3726

Published Date: 29 October 2019

Cardio- Renal Outcomes With Long- Term Agalsidase Alfa Enzyme Replacement Therapy: A 10- Year Fabry Outcome Survey (FOS) Analysis

Ramaswami U, Beck M, Hughes D, Kampmann C, Botha J, Pintos-Morell G, West ML, Niu DM, Nicholls K, Giugliani R

Drug Design, Development and Therapy 2019, 13:3705-3715

Published Date: 25 October 2019

Exosomes Derived From Bone Marrow Mesenchymal Stem Cells Inhibit Complement Activation In Rats With Spinal Cord Injury

Zhao C, Zhou X, Qiu J, Xin D, Li T, Chu X, Yuan H, Wang H, Wang Z, Wang D

Drug Design, Development and Therapy 2019, 13:3693-3704

Published Date: 24 October 2019

Glucoside Derivatives Of Podophyllotoxin: Synthesis, Physicochemical Properties, And Cytotoxicity

Zi CT, Yang L, Kong QH, Li HM, Yang XZ, Ding ZT, Jiang ZH, Hu JM, Zhou J

Drug Design, Development and Therapy 2019, 13:3683-3692

Published Date: 23 October 2019

Olmesartan Medoxomil, An Angiotensin II-Receptor Blocker, Ameliorates Renal Injury In db/db Mice

Zhu Y, Li ZL, Ding A, Yang H, Zhu WP, Cui TX, Zhang HT, Zhang H

Drug Design, Development and Therapy 2019, 13:3657-3667

Published Date: 22 October 2019

The Effect Of Food On The Pharmacokinetic Properties And Bioequivalence Of Two Formulations Of Levocetirizine Dihydrochloride In Healthy Chinese Volunteers

Cheng Y, Lin BJ, Guo JH, Huang BL, Fang LP, Que WC, Liu MB, Chen XF, Qiu HQ

Drug Design, Development and Therapy 2019, 13:3625-3634

Published Date: 18 October 2019

In-vitro blood-brain barrier models for drug screening and permeation studies: an overview

Bagchi S, Chhibber T, Lahooti B, Verma A, Borse V, Jayant RD

Drug Design, Development and Therapy 2019, 13:3591-3605

Published Date: 18 October 2019

Diammonium Glycyrrhizinate Mitigates Liver Injury Via Inhibiting Proliferation Of NKT Cells And Promoting Proliferation Of Tregs

Gao M, Li X, He L, Yang J, Ye X, Xiao F, Wei H

Drug Design, Development and Therapy 2019, 13:3579-3589

Published Date: 16 October 2019

Indole-2-Carboxamide Derivative LG25 Inhibits Triple-Negative Breast Cancer Growth By Suppressing Akt/mTOR/NF-κB Signalling Pathway

Xu X, Rajamanickam V, Shu S, Liu Z, Yan T, He J, Liu Z, Guo G, Liang G, Wang Y

Drug Design, Development and Therapy 2019, 13:3539-3550

Published Date: 11 October 2019

Aucubin Protects Chondrocytes Against IL-1β-Induced Apoptosis In Vitro And Inhibits Osteoarthritis In Mice Model

Wang B, Jiang Y, Yao Z, Chen P, Yu B, Wang S

Drug Design, Development and Therapy 2019, 13:3529-3538

Published Date: 9 October 2019

20(S)-Ginsenoside Rg3 Promotes Senescence And Apoptosis In Gallbladder Cancer Cells Via The P53 Pathway [Corrigendum]

Zhang F, Li M, Wu X, Hu Y, Cao Y, Wang X, Xiang S, Li H, Jiang L, Tan Z, Lu W, Weng H, Shu Y, Gong W, Wang X, Zhang Y, Shi W, Dong P, Gu J, Liu Y

Drug Design, Development and Therapy 2019, 13:3527-3528

Published Date: 8 October 2019

Thrombospondin-1 Serum Levels In Hypertensive Patients With Endothelial Dysfunction After One Year Of Treatment With Perindopril

Buda V, Andor M, Cristescu C, Tomescu MC, Muntean DM, Bâibâță DE, Bordejevic DA, Danciu C, Dalleur O, Coricovac D, Crainiceanu Z, Tudor A, Ledeti I, Petrescu L

Drug Design, Development and Therapy 2019, 13:3515-3526

Published Date: 8 October 2019

The Osteoprotective Effects Of Kaempferol: The Evidence From In Vivo And In Vitro Studies

Wong SK, Chin KY, Ima-Nirwana S

Drug Design, Development and Therapy 2019, 13:3497-3514

Published Date: 7 October 2019

Enzyme Inhibitory, Antioxidant And Antibacterial Potentials Of Synthetic Symmetrical And Unsymmetrical Thioureas

Naz S, Zahoor M, Umar MN, Ali B, Ullah R, Shahat AA, Mahmood HM, Sahibzada MUK

Drug Design, Development and Therapy 2019, 13:3485-3495

Published Date: 7 October 2019

Dexmedetomidine Attenuates Neuroinflammation In LPS-Stimulated BV2 Microglia Cells Through Upregulation Of miR-340

Bao Y, Zhu Y, He G, Ni H, Liu C, Ma L, Zhang L, Shi D

Drug Design, Development and Therapy 2019, 13:3465-3475

Published Date: 3 October 2019

Efficacy, Safety And Feasibility Of Antiemetic Prophylaxis With Fosaprepitant, Granisetron And Dexamethasone In Pediatric Patients With Hemato-Oncological Malignancies

Cabanillas Stanchi KM, Ebinger M, Hartmann U, Queudeville M, Feucht J, Ost M, Koch MS, Malaval C, Mezger M, Schober S, Weber S, Michaelis S, Lange V, Lang P, Handgretinger R, Döring M

Drug Design, Development and Therapy 2019, 13:3439-3451

Published Date: 30 September 2019

The Efficacy And Safety Of Apatinib Treatment For Patients With Metastatic Or Recurrent Cervical Cancer: A Retrospective Study

Yu J, Xu Z, Li A, Zhang J, Wang Y, Zhao H, Zhu H

Drug Design, Development and Therapy 2019, 13:3419-3424

Published Date: 26 September 2019

Hydrogels For Peptide Hormones Delivery: Therapeutic And Tissue Engineering Applications

Doostmohammadi M, Ameri A, Mohammadinejad R, Dehghannoudeh N, Banat IM, Ohadi M, Dehghannoudeh G

Drug Design, Development and Therapy 2019, 13:3405-3418

Published Date: 26 September 2019

Paclitaxel alleviated sepsis-induced acute lung injury by activating MUC1 and suppressing TLR-4/NF-κB pathway

Wang YM, Ji R, Chen WW, Huang SW, Zheng YJ, Yang ZT, Qu HP, Chen H, Mao EQ, Chen Y, Chen EZ

Drug Design, Development and Therapy 2019, 13:3391-3404

Published Date: 24 September 2019

Design, Synthesis, And Evaluation Of Cyanopyridines As Anti-Colorectal Cancer Agents Via Inhibiting STAT3 Pathway

Xu L, Shi L, Qiu S, Chen S, Lin M, Xiang Y, Zhao C, Zhu J, Shen L, Zuo Z

Drug Design, Development and Therapy 2019, 13:3369-3381

Published Date: 24 September 2019

Effects of loratadine, a histamine H1 receptor antagonist, on the skeletal system of young male rats

Folwarczna J, Konarek N, Freier K, Karbowniczek D, Londzin P, Janas A

Drug Design, Development and Therapy 2019, 13:3357-3367

Published Date: 23 September 2019

Effect Of Chinese Herb Danzhi Xiaoyao Pills On Pharmacokinetics Of Venlafaxine In Beagles

Zhu Y, Li S, Chen K, Ma K, Wu D, Qiu X

Drug Design, Development and Therapy 2019, 13:3343-3355

Published Date: 20 September 2019

Bioequivalence Study Of A Fixed-Dose Combination Tablet Containing Melitracen 10 mg And Flupentixol 0.5 mg In Healthy Chinese Volunteers Under Fasted And Fed Conditions

Wu L, Xu C, Wu G, Zhou H, Lv D, Zhai Y, Huang Y, Tang W, Li F, Shentu J

Drug Design, Development and Therapy 2019, 13:3331-3342

Published Date: 19 September 2019

Effects of quercetin, sitagliptin alone or in combination in testicular toxicity induced by doxorubicin in rats

Ahmed ZA, Abtar AN, Othman HH, Aziz TA

Drug Design, Development and Therapy 2019, 13:3321-3329

Published Date: 20 September 2019

Muscone Promotes The Adipogenic Differentiation Of Human Gingival Mesenchymal Stem Cells By Inhibiting The Wnt/β-Catenin Signaling Pathway

Yuan WX, Wang XX, Zheng DH, Ma D, Cui Q, Yang F, Zhang J

Drug Design, Development and Therapy 2019, 13:3291-3306

Published Date: 18 September 2019

A novel curcumin-loaded composite dressing facilitates wound healing due to its natural antioxidant effect

Zhao Y, Dai C, Wang Z, Chen W, Liu J, Zhuo R, Yu A, Huang S

Drug Design, Development and Therapy 2019, 13:3269-3280

Published Date: 16 September 2019

Carbocisteine inhibits the expression of Muc5b in COPD mouse model

Song Y, Wang W, Xie Y, Xiang B, Huang X, Guan W, Zheng J

Drug Design, Development and Therapy 2019, 13:3259-3268

Published Date: 16 September 2019

Identification of substandard drug products using electronic tongue: cefdinir suspension as a pilot example

Abu-Khalaf N, Zaid AN, Jaradat N, Alkilany AM, Abulateefeh SR, Al Ramahi R, Ghanem M

Drug Design, Development and Therapy 2019, 13:3249-3258

Published Date: 16 September 2019

Preclinical pharmacodynamic and pharmacokinetic characterization of the major metabolites of cariprazine

Kiss B, Némethy Z, Fazekas K, Kurkó D, Gyertyán I, Sághy K, Laszlovszky I, Farkas B, Kirschner N, Bolf-Terjéki E, Balázs O, Lendvai B

Drug Design, Development and Therapy 2019, 13:3229-3248

Published Date: 16 September 2019

Ubenimex induces apoptotic and autophagic cell death in rat GH3 and MMQ cells through the ROS/ERK pathway

Wang Y, Pang B, Zhang R, Fu Y, Pang Q

Drug Design, Development and Therapy 2019, 13:3217-3228

Published Date: 12 September 2019

Palliative chemotherapy with or without anti-EGFR therapy for de novo metastatic nasopharyngeal carcinoma: a propensity score-matching study

Sun XS, Liang YJ, Li XY, Liu SL, Chen QY, Tang LQ, Mai HQ

Drug Design, Development and Therapy 2019, 13:3207-3216

Published Date: 10 September 2019

Downregulation of p66Shc can reduce oxidative stress and apoptosis in oxidative stress model of marginal cells of stria vascularis in Sprague Dawley rats

Hao C, Wu X, Zhou R, Zhang H, Zhou Y, Wang X, Feng Y, Mei L, He C, Cai X, Wu L

Drug Design, Development and Therapy 2019, 13:3199-3206

Published Date: 10 September 2019

Omalizumab for chronic spontaneous urticaria in “complex” patients: data from real-life clinical practice

Vollono L, Piccolo A, Lanna C, Esposito M, Bavetta M, Campione E, Bianchi L, Diluvio L

Drug Design, Development and Therapy 2019, 13:3181-3186

Published Date: 6 September 2019

Emodin-induced autophagy against cell apoptosis through the PI3K/AKT/mTOR pathway in human hepatocytes

Zheng X, Yang S, Zhang R, Wang S, Li G, Zhou S

Drug Design, Development and Therapy 2019, 13:3171-3180

Published Date: 3 September 2019

Mifepristone inhibits IGF-1 signaling pathway in the treatment of uterine leiomyomas

Shen Q, Zou S, Sheng B, Zhao M, Sun LZ, Zhu X

Drug Design, Development and Therapy 2019, 13:3161-3170

Published Date: 3 September 2019

Dexmedetomidine protects H9c2 cardiomyocytes against oxygen-glucose deprivation/reoxygenation-induced intracellular calcium overload and apoptosis through regulating FKBP12.6/RyR2 signaling

Yuan M, Meng XW, Ma J, Liu H, Song SY, Chen QC, Liu HY, Zhang J, Song N, Ji FH, Peng K

Drug Design, Development and Therapy 2019, 13:3137-3149

Published Date: 2 September 2019

Pharmacokinetic and bioequivalence study between two formulations of S-1 in Korean gastric cancer patients

Lee HW, Seong SJ, Kang WY, Ohk B, Gwon MR, Kim BK, Cho S, Cho K, Sung YK, Yoon YR, Kim JG

Drug Design, Development and Therapy 2019, 13:3127-3136

Published Date: 3 September 2019

Silibinin attenuates high-fat diet-induced renal fibrosis of diabetic nephropathy

Liu K, Zhou S, Liu J, Wang Y, Zhu F, Liu M

Drug Design, Development and Therapy 2019, 13:3117-3126

Published Date: 29 August 2019

Therapeutic potential of BLT1 antagonist for COPD: involvement of inducing autophagy and ameliorating inflammation

Zhang L, Huang J, Dong R, Feng Y, Zhou M

Drug Design, Development and Therapy 2019, 13:3105-3116

Published Date: 4 September 2019

Polyphyllin VI induces apoptosis and autophagy in human osteosarcoma cells by modulation of ROS/JNK activation

Yuan YL, Jiang N, Li ZY, Song ZZ, Yang ZH, Xue WH, Zhang XJ, Du Y

Drug Design, Development and Therapy 2019, 13:3091-3103

Published Date: 28 August 2019

Antiproliferative activity and possible mechanism of action of certain 5-methoxyindole tethered C-5 functionalized isatins

Almutairi MS, Hassan ES, Keeton AB, Piazza GA, Abdelhameed AS, Attia MI

Drug Design, Development and Therapy 2019, 13:3069-3078

Published Date: 27 August 2019

Ketamine and depression: a narrative review

Corriger A, Pickering G

Drug Design, Development and Therapy 2019, 13:3051-3067

Published Date: 27 August 2019

Arsenic sulfide induces miR-4665-3p to inhibit gastric cancer cell invasion and migration

Zhang X, Tan Z, Kang T, Zhu C, Chen S

Drug Design, Development and Therapy 2019, 13:3037-3049

Published Date: 26 August 2019

Isolation, pharmacological evaluation and molecular docking studies of bioactive compounds from Grewia optiva

Ul Bari W, Zahoor M, Zeb A, Sahibzada MUK, Ullah R, Shahat AA, Mahmood HM, Khan I

Drug Design, Development and Therapy 2019, 13:3029-3036

Published Date: 26 August 2019

Synthesis and antitumor evaluation of neolaxiflorin B inspired compounds

Liu JP, Xiao YZ, Hu Y, Li XN, Wu MJ, Zhao Y, Zhao Y, Ma ZJ, Shen J

Drug Design, Development and Therapy 2019, 13:3021-3028

Published Date: 23 August 2019

Network pharmacology study on the active components of Pterocypsela elata and the mechanism of their effect against cerebral ischemia

Niu B, Zhang H, Li C, Yan F, Song Y, Hai G, Jiao Y, Feng Y

Drug Design, Development and Therapy 2019, 13:3009-3019

Published Date: 5 September 2019

The development of an oral GLP-1 receptor agonist for the management of type 2 diabetes: evidence to date

Antza C, Nirantharakumar K, Doundoulakis I, Tahrani AA, Toulis KA

Drug Design, Development and Therapy 2019, 13:2985-2996

Published Date: 22 August 2019

Attractor – a new turning point in drug discovery

Hou X, Li M, Jia C, Zhang X, Wang Y

Drug Design, Development and Therapy 2019, 13:2957-2968

Published Date: 22 August 2019

Total extract of Xin Jia Xuan Bai Cheng Qi decoction inhibits pulmonary fibrosis via the TGF-β/Smad signaling pathways in vivo and in vitro

Qin H, Wen HT, Gu KJ, Hu XD, Yang T, Yan XF, Ye TJ, Huo JL, Hu J

Drug Design, Development and Therapy 2019, 13:2873-2886

Published Date: 19 August 2019

Validated UPLC-MS/MS method for quantification of fruquintinib in rat plasma and its application to pharmacokinetic study

Mei YB, Luo SB, Ye LY, Zhang Q, Guo J, Qiu XJ, Xie SL

Drug Design, Development and Therapy 2019, 13:2865-2871

Published Date: 15 August 2019

Overexpression of SOX9 alleviates the progression of human osteoarthritis in vitro and in vivo

Ouyang Y, Wang W, Tu B, Zhu Y, Fan C, Li Y

Drug Design, Development and Therapy 2019, 13:2833-2842

Published Date: 13 August 2019

Protective effects of tiopronin against oxidative stress in severely burned patients

Qin FJ, Hu XH, Chen Z, Chen X, Shen YM

Drug Design, Development and Therapy 2019, 13:2827-2832

Published Date: 13 August 2019

eIF2α promotes vascular remodeling via autophagy in monocrotaline-induced pulmonary arterial hypertension rats

Guo L, Li Y, Tian Y, Gong S, Chen X, Peng T, Wang A, Jiang Z

Drug Design, Development and Therapy 2019, 13:2799-2809

Published Date: 13 August 2019

Minoxidil and its use in hair disorders: a review

Suchonwanit P, Thammarucha S, Leerunyakul K

Drug Design, Development and Therapy 2019, 13:2777-2786

Published Date: 9 August 2019

Effects of acarbose and metformin on the inflammatory state in newly diagnosed type 2 diabetes patients: a one-year randomized clinical study

Mo D, Liu S, Ma H, Tian H, Yu H, Zhang X, Tong N, Liao J, Ren Y

Drug Design, Development and Therapy 2019, 13:2769-2776

Published Date: 9 August 2019

Cerebral protection of epigallocatechin gallate (EGCG) via preservation of mitochondrial function and ERK inhibition in a rat resuscitation model

Qin S, Chen MH, Fang W, Tan XF, Xie L, Yang YG, Qin T, Li N

Drug Design, Development and Therapy 2019, 13:2759-2768

Published Date: 7 August 2019

Liraglutide attenuates cardiac remodeling and improves heart function after abdominal aortic constriction through blocking angiotensin II type 1 receptor in rats

Zheng RH, Bai XJ, Zhang WW, Wang J, Bai F, Yan CP, James EA, Bose HS, Wang NP, Zhao Z

Drug Design, Development and Therapy 2019, 13:2745-2757

Published Date: 6 August 2019

Neuroprotective effects of melatonin and celecoxib against ethanol-induced neurodegeneration: a computational and pharmacological approach

Al Kury LT, Zeb A, Abidin ZU, Irshad N, Malik I, Alvi AM, Khalil AAK, Ahmad S, Faheem M, Khan AU, Shah FA, Li S

Drug Design, Development and Therapy 2019, 13:2715-2727

Published Date: 2 August 2019

Orcinol glucoside facilitates the shift of MSC fate to osteoblast and prevents adipogenesis via Wnt/β-catenin signaling pathway

Zhou X, Liu Z, Huang B, Yan H, Yang C, Li Q, Jin D

Drug Design, Development and Therapy 2019, 13:2703-2713

Published Date: 5 August 2019

Systemic taurine treatment provides neuroprotection against retinal photoreceptor degeneration and visual function impairments

Tao Y, He M, Yang Q, Ma Z, Qu Y, Chen W, Peng G, Teng D

Drug Design, Development and Therapy 2019, 13:2689-2702

Published Date: 7 August 2019

Dextromethorphan and memantine after ketamine analgesia: a randomized control trial

Martin E, Sorel M, Morel V, Marcaillou F, Picard P, Delage N, Tiberghien F, Crosmary MC, Najjar M, Colamarino R, Créach C, Lietar B, Brumauld de Montgazon G, Margot-Duclot A, Loriot MA, Narjoz C, Lambert C, Pereira B, Pickering G

Drug Design, Development and Therapy 2019, 13:2677-2688

Published Date: 2 August 2019

Carvedilol attenuates carbon tetrachloride-induced liver fibrosis and hepatic sinusoidal capillarization in mice

Wu Y, Li Z, Xiu AY, Meng DX, Wang SN, Zhang CQ

Drug Design, Development and Therapy 2019, 13:2667-2676

Published Date: 1 August 2019

An investigation of the stability of meropenem in elastomeric infusion devices

Foy F, Luna G, Martinez J, Nizich Z, Seet J, Lie K, Sunderland B, Czarniak P

Drug Design, Development and Therapy 2019, 13:2655-2665

Published Date: 1 August 2019

Efficacy of chloral hydrate oral solution for sedation in pediatrics: a systematic review and meta-analysis

Chen Z, Lin M, Huang Z, Zeng L, Huang L, Yu D, Zhang L

Drug Design, Development and Therapy 2019, 13:2643-2653

Published Date: 31 July 2019

Effects of ondansetron and [6]-gingerol on pica and gut microbiota in rats treated with cisplatin

Feng X, Cheng Q, Meng Q, Yang Y, Nie K

Drug Design, Development and Therapy 2019, 13:2633-2641

Published Date: 1 August 2019

Role of heat shock protein 22 in the protective effect of geranylgeranylacetone in response to oxidized-LDL

Gong R, Li XY, Chen HJ, Xu CC, Fang HY, Xiang J, Wu YQ

Drug Design, Development and Therapy 2019, 13:2619-2632

Published Date: 30 July 2019

Effects of losartan and atorvastatin on the development of early posttraumatic joint stiffness in a rat model

Baranowski A, Schlemmer L, Förster K, Slotina E, Mickan T, Truffel S, Klein A, Mattyasovszky SG, Hofmann A, Ritz U, Rommens PM

Drug Design, Development and Therapy 2019, 13:2603-2618

Published Date: 30 July 2019

Astragaloside IV protects endothelial progenitor cells from the damage of ox-LDL via the LOX-1/NLRP3 inflammasome pathway

Qian W, Cai X, Qian Q, Zhuang Q, Yang W, Zhang X, Zhao L

Drug Design, Development and Therapy 2019, 13:2579-2589

Published Date: 29 July 2019

Erythropoietin enhances osteogenic differentiation of human periodontal ligament stem cells via Wnt/β-catenin signaling pathway

Zheng DH, Wang XX, Ma D, Zhang LN, Qiao QF, Zhang J

Drug Design, Development and Therapy 2019, 13:2543-2552

Published Date: 26 July 2019

Downregulation of microRNA-23b-3p alleviates IL-1β-induced injury in chondrogenic CHON-001 cells

Yang Q, Zhou Y, Cai P, Fu W, Wang J, Wei Q, Li X

Drug Design, Development and Therapy 2019, 13:2503-2512

Published Date: 23 July 2019

Physicochemical properties and drug-release mechanisms of dual-release bilayer tablet containing mirabegron and fesoterodine fumarate

Lee HG, Park YS, Jeong JH, Kwon YB, Shin DH, Kim JY, Rhee YS, Park ES, Kim DW, Park CW

Drug Design, Development and Therapy 2019, 13:2459-2474

Published Date: 23 July 2019

Synthesis and antihepatotoxic activity of dihydropyrimidinone derivatives linked with 1,4-benzodioxane

Bhat MA, Al-Omar MA, Khan AA, Alanazi AM, Naglah AM

Drug Design, Development and Therapy 2019, 13:2393-2404

Published Date: 18 July 2019

A new approach of ocular nebulization with vitamin B12 versus oxytocin for the treatment of dry eye disease: an in vivo confocal microscopy study

Yang J, Liu Y, Xu Y, Li X, Fu J, Jiang X, Chou Y, Ma J, Hao R, Zhang R, Qiu W, Li X

Drug Design, Development and Therapy 2019, 13:2381-2391

Published Date: 18 July 2019

MicroRNA-664 suppresses the growth of cervical cancer cells via targeting c-Kit

Lv M, Ou R, Zhang Q, Lin F, Li X, Wang K, Xu Y

Drug Design, Development and Therapy 2019, 13:2371-2379

Published Date: 17 July 2019

Plumbagin promotes human hepatoma SMMC-7721 cell apoptosis via caspase-3/vimentin signal-mediated EMT

Wei Y, Lv B, Xie J, Zhang Y, Lin Y, Wang S, Zhong J, Chen Y, Peng Y, Ma J

Drug Design, Development and Therapy 2019, 13:2343-2355

Published Date: 15 July 2019

Lycopene protects against myocardial ischemia-reperfusion injury by inhibiting mitochondrial permeability transition pore opening

Li X, Jia P, Huang Z, Liu S, Miao J, Guo Y, Wu N, Jia D

Drug Design, Development and Therapy 2019, 13:2331-2342

Published Date: 11 July 2019

Differences in tolerability of pirfenidone between elderly and younger patients with idiopathic pulmonary fibrosis

Sakayori M, Terada J, Abe M, Hirasawa Y, Suzuki K, Yoshioka K, Tsushima K, Tatsumi K

Drug Design, Development and Therapy 2019, 13:2295-2303

Published Date: 11 July 2019

Durability of INI-containing regimens after switching from PI-containing regimens: a single-centre cohort of drug-experienced HIV-infected subjects

Giacomelli A, Ranzani A, Oreni L, Gervasi E, Lupo A, Ridolfo AL, Galli M, Rusconi S

Drug Design, Development and Therapy 2019, 13:2271-2282

Published Date: 9 July 2019

The protective effect and mechanism of the FXR agonist obeticholic acid via targeting gut microbiota in non-alcoholic fatty liver disease

Zhang DY, Zhu L, Liu HN, Tseng YJ, Weng SQ, Liu TT, Dong L, Shen XZ

Drug Design, Development and Therapy 2019, 13:2249-2270

Published Date: 5 July 2019

Jatrorrhizine inhibits colorectal carcinoma proliferation and metastasis through Wnt/β-catenin signaling pathway and epithelial–mesenchymal transition

Wang P, Gao XY, Yang SQ, Sun ZX, Dian LL, Qasim M, Phyo AT, Liang ZS, Sun YF

Drug Design, Development and Therapy 2019, 13:2235-2247

Published Date: 8 July 2019

Delivery of folic acid-modified liposomal curcumin for targeted cervical carcinoma therapy

Wang WY, Cao YX, Zhou X, Wei B

Drug Design, Development and Therapy 2019, 13:2205-2213

Published Date: 4 July 2019

Activation of the P38/CREB/MMP13 axis is associated with osteoarthritis

Ji B, Ma Y, Wang H, Fang X, Shi P

Drug Design, Development and Therapy 2019, 13:2195-2204

Published Date: 3 July 2019

Tablet or capsule form of generic mycophenolate mofetil (My-Rept®) after liver transplantation: a prospective randomized trial

Kim JM, Oh JW, Kim S, Rhu J, Lee JS, Kim KS, Choi GS, Joh JW

Drug Design, Development and Therapy 2019, 13:2187-2193

Published Date: 2 July 2019

Evaluation of novel pyrimidine derivatives as a new class of mushroom tyrosinase inhibitor

Mirmortazavi SS, Farvandi M, Ghafouri H, Mohammadi A, Shourian M

Drug Design, Development and Therapy 2019, 13:2169-2178

Published Date: 8 July 2019

Preemptive analgesia after lumbar spine surgery by pregabalin and celecoxib: a prospective study

Kien NT, Geiger P, Van Chuong H, Cuong NM, Van Dinh N, Pho DC, Anh VT, Giang NT

Drug Design, Development and Therapy 2019, 13:2145-2152

Published Date: 3 July 2019

Role of GRP78 inhibiting artesunate-induced ferroptosis in KRAS mutant pancreatic cancer cells

Wang K, Zhang Z, Wang M, Cao X, Qi J, Wang D, Gong A, Zhu H

Drug Design, Development and Therapy 2019, 13:2135-2144

Published Date: 2 July 2019

Ginsenoside Rb1 pretreatment reverses hippocampal changes in BDNF/TrkB mRNA and protein in rats subjected to acute immobilization stress

Kang X, Hong W, Xie K, Tang H, Tang J, Luo S, Geng W, Jia D

Drug Design, Development and Therapy 2019, 13:2127-2134

Published Date: 1 July 2019

Phosphocreatine attenuates Gynura segetum-induced hepatocyte apoptosis via a SIRT3-SOD2-mitochondrial reactive oxygen species pathway

Li DP, Chen YL, Jiang HY, Chen Y, Zeng XQ, Xu LL, Ye Y, Ke CQ, Lin G, Wang JY, Gao H

Drug Design, Development and Therapy 2019, 13:2081-2096

Published Date: 27 June 2019

Dexmedetomidine protects PC12 cells from lidocaine-induced cytotoxicity via downregulation of Stathmin 1

Tan Y, Bi X, Wang Q, Li Y, Zhang N, Lao J, Liu X

Drug Design, Development and Therapy 2019, 13:2067-2079

Published Date: 3 July 2019

Ginsenoside Rg3 protects mouse leydig cells against triptolide by downregulation of miR-26a

Liang H, Zhang S, Li Z

Drug Design, Development and Therapy 2019, 13:2057-2066

Published Date: 24 June 2019

A novel mutation panel for predicting etoposide resistance in small-cell lung cancer

Qiu Z, Lin A, Li K, Lin W, Wang Q, Wei T, Zhu W, Luo P, Zhang J

Drug Design, Development and Therapy 2019, 13:2021-2041

Published Date: 21 June 2019

TMF inhibits miR-29a/Wnt/β-catenin signaling through upregulating Foxo3a activity in osteoarthritis chondrocytes

Huang X, Chen Z, Shi W, Zhang R, Li L, Liu H, Wu L

Drug Design, Development and Therapy 2019, 13:2009-2019

Published Date: 19 June 2019

Evaluating guselkumab: an anti-IL-23 antibody for the treatment of plaque psoriasis

Yang EJ, Smith MP, Ly K, Bhutani T

Drug Design, Development and Therapy 2019, 13:1993-2000

Published Date: 18 June 2019

Efficacy and safety of total glucosides of paeony combined with methotrexate and leflunomide for active rheumatoid arthritis: a meta-analysis

Huang Y, Wang H, Chen Z, Wang Y, Qin K, Huang Y, Ba X, Lin W, Tu S

Drug Design, Development and Therapy 2019, 13:1969-1984

Published Date: 17 June 2019

The neuroprotective effect of bisperoxovandium (pyridin-2-squaramide) in intracerebral hemorrhage

Liao XY, Lei Y, Chen SF, Cheng J, Zhao D, Zhang ZF, Han X, Zhang Y, Liao HB, Zhuang Y, Chen J, Zhou HB, Wan Q, Zou YY

Drug Design, Development and Therapy 2019, 13:1957-1967

Published Date: 13 June 2019

Solutol®HS15+pluronicF127 and Solutol®HS15+pluronicL61 mixed micelle systems for oral delivery of genistein

Ding P, Chen Y, Cao G, Shen H, Ju J, Li W

Drug Design, Development and Therapy 2019, 13:1947-1956

Published Date: 7 June 2019

Notopterol-induced apoptosis and differentiation in human acute myeloid leukemia HL-60 cells

Huang Q, Wang L, Ran Q, Wang J, Wang C, He H, Li L, Qi H

Drug Design, Development and Therapy 2019, 13:1927-1940

Published Date: 6 June 2019

Decreased sEng plasma levels in hypertensive patients with endothelial dysfunction under chronic treatment with Perindopril

Buda V, Andor M, Baibata DE, Cozlac R, Radu G, Coricovac D, Danciu C, Ledeti I, Cheveresan A, Nica C, Tuduce P, Tomescu MC

Drug Design, Development and Therapy 2019, 13:1915-1925

Published Date: 4 June 2019

Effects of Qi Teng Xiao Zhuo granules on circRNA expression profiles in rats with chronic glomerulonephritis

Gao JR, Jiang NN, Jiang H, Wei LB, Gao YC, Qin XJ, Zhu MQ, Wang J

Drug Design, Development and Therapy 2019, 13:1901-1913

Published Date: 4 June 2019

Efficacy and toxicity of cladribine for the treatment of refractory acute myeloid leukemia: a meta-analysis

Zhou A, Han Q, Song H, Zi J, Ma J, Ge Z

Drug Design, Development and Therapy 2019, 13:1867-1878

Published Date: 29 May 2019

Therapeutic potential of pravastatin for random skin flaps necrosis: involvement of promoting angiogenesis and inhibiting apoptosis and oxidative stress [Corrigendum]

Lin J, Jia C, Wang Y, Jiang S, Jia Z, Chen N, Sheng S, Li S, Jiang L, Xu H, Zhou K, Chen Y

Drug Design, Development and Therapy 2019, 13:1865-1866

Published Date: 29 May 2019

Use of lidocaine to prevent postoperative coughing after partial laryngectomy: comparison of three delivery methods

Wang Y, Lu WS, Qiao H, Zhao J, Fan Q

Drug Design, Development and Therapy 2019, 13:1835-1841

Published Date: 27 May 2019

A novel non-invasive monitoring assay of 5-azacitidine efficacy using global DNA methylation of peripheral blood in myelodysplastic syndrome

Asano M, Ohyashiki JH, Kobayashi-Kawana C, Umezu T, Imanishi S, Azuma K, Akahane D, Fujimoto H, Ito Y, Ohyashiki K

Drug Design, Development and Therapy 2019, 13:1821-1833

Published Date: 30 May 2019

Ferulic acid attenuates liver fibrosis and hepatic stellate cell activation via inhibition of TGF-β/Smad signaling pathway [Corrigendum]

Mu M, Zuo S, Wu RM, Deng KS, Lu S, Zhu JJ, Zou GL, Yang J, Cheng ML, Zhao XK

Drug Design, Development and Therapy 2019, 13:1819-1820

Published Date: 24 May 2019

Frequency, clinical features and differential response to therapy of concurrent ALK/EGFR alterations in Chinese lung cancer patients

Liu J, Mu Z, Liu L, Li K, Jiang R, Chen P, Zhou Q, Jin M, Ma Y, Xie Y, Xiang J, Li B, Ma Y, Mao X, Zhang L, Zhang T, Wu D

Drug Design, Development and Therapy 2019, 13:1809-1817

Published Date: 23 May 2019

Effect of dexmedetomidine on etomidate-induced myoclonus: a randomized, double-blind controlled trial

Miao S, Zou L, Wang G, Wang X, Liu S, Shi M

Drug Design, Development and Therapy 2019, 13:1803-1808

Published Date: 27 May 2019

Low-dose doxycycline inhibits hydrogen peroxide-induced oxidative stress, MMP-2 up-regulation and contractile dysfunction in human saphenous vein grafts

Saeed M, Arun MZ, Guzeloglu M, Onursal C, Gokce G, Korkmaz CG, Reel B

Drug Design, Development and Therapy 2019, 13:1791-1801

Published Date: 23 May 2019

Synthesis, comparative docking, and pharmacological activity of naproxen amino acid derivatives as possible anti-inflammatory and analgesic agents

Elhenawy AA, Al-Harbi LM, Moustafa GO, El-Gazzar MA, Abdel-Rahman RF, Salim AE

Drug Design, Development and Therapy 2019, 13:1773-1790

Published Date: 24 May 2019

SU5416 attenuated lipopolysaccharide-induced acute lung injury in mice by modulating properties of vascular endothelial cells

Huang X, Zhu J, Jiang Y, Xu C, Lv Q, Yu D, Shi K, Ruan Z, Wang Y

Drug Design, Development and Therapy 2019, 13:1763-1772

Published Date: 23 May 2019

Population pharmacokinetic analysis of tramadol and O-desmethyltramadol with genetic polymorphism of CYP2D6

Lee J, Yoo H, Bae JW, Lee S, Shin K

Drug Design, Development and Therapy 2019, 13:1751-1761

Published Date: 23 May 2019

The effect of midazolam administration for the prevention of emergence agitation in pediatric patients with extreme fear and non-cooperation undergoing dental treatment under sevoflurane anesthesia, a double-blind, randomized study

Kawai M, Kurata S, Sanuki T, Mishima G, Kiriishi K, Watanabe T, Ozaki-Honda Y, Yoshida M, Okayasu I, Ayuse T, Tanoue N, Ayuse T

Drug Design, Development and Therapy 2019, 13:1729-1737

Published Date: 17 May 2019

Genetic variations in the transcription factors GATA4 and GATA6 and bleeding complications in patients receiving warfarin therapy

Yee J, Kim W, Chang BC, Chung JE, Lee KE, Gwak HS

Drug Design, Development and Therapy 2019, 13:1717-1727

Published Date: 17 May 2019

Sevoflurane post-conditioning alleviates neonatal rat hypoxic-ischemic cerebral injury via Ezh2-regulated autophagy

Xue H, Xu Y, Wang S, Wu ZY, Li XY, Zhang YH, Niu JY, Gao QS, Zhao P

Drug Design, Development and Therapy 2019, 13:1691-1706

Published Date: 15 May 2019

Efficacy of a recombinant single-chain fragment variable region, VasSF, as a new drug for vasculitis [Corrigendum]

Kameoka Y, Kishi F, Koura M, Yamakawa Y, Nagasawa R, Ito F, Matsuda J, Suzuki O, Nakayama T, Suzuki K

Drug Design, Development and Therapy 2019, 13:1689-1690

Published Date: 22 May 2019

Cardiovascular adverse events during treatment with darunavir-based regimens in an Italian observational study

Antinori A, Rusconi S, Gianotti N, Bini T, Mancusi D, Termini R

Drug Design, Development and Therapy 2019, 13:1667-1685

Published Date: 14 May 2019

Dexibuprofen amide derivatives as potential anticancer agents: synthesis, in silico docking, bioevaluation, and molecular dynamic simulation

Ashraf Z, Mahmood T, Hassan M, Afzal S, Rafique H, Afzal K, Latip J

Drug Design, Development and Therapy 2019, 13:1643-1657

Published Date: 14 May 2019

Pharmacokinetics of fixed-dose combination of atorvastatin and metformin compared with individual tablets

Ghim JL, Phuong NTT, Kim MJ, Kim EJ, Song GS, Ahn S, Shin JG, Kim EY

Drug Design, Development and Therapy 2019, 13:1623-1632

Published Date: 13 May 2019

Formulation and evaluation of simvastatin polymeric nanoparticles loaded in hydrogel for optimum wound healing purpose

Farghaly Aly U, Abou-Taleb HA, Abdellatif AH, Sameh Tolba N

Drug Design, Development and Therapy 2019, 13:1567-1580

Published Date: 10 May 2019

In silico and in vitro studies of lupeol and iso-orientin as potential antidiabetic agents in a rat model

Malik A, Jamil U, Butt TT, Waquar S, Gan SH, Shafique H, Jafar TH

Drug Design, Development and Therapy 2019, 13:1501-1513

Published Date: 6 May 2019

Resveratrol reduces liver endoplasmic reticulum stress and improves insulin sensitivity in vivo and in vitro

Zhao H, Zhang Y, Shu L, Song G, Ma H

Drug Design, Development and Therapy 2019, 13:1473-1485

Published Date: 2 May 2019

Therapeutic potential of pravastatin for random skin flaps necrosis: involvement of promoting angiogenesis and inhibiting apoptosis and oxidative stress

Lin J, Jia C, Wang Y, Jiang S, Jia Z, Chen N, Sheng S, Li S, Jiang L, Xu H, Zhou K, Chen Y

Drug Design, Development and Therapy 2019, 13:1461-1472

Published Date: 1 May 2019

Synthesis of a vanadyl (IV) folate complex for the treatment of diabetes: spectroscopic, structural, and biological characterization

Naglah AM, Refat MS, Al-Omar MA, Bhat MA, AlKahtani HM, Al-Wasidi AS

Drug Design, Development and Therapy 2019, 13:1409-1420

Published Date: 30 April 2019

The TwistDock workflow for evaluation of bivalent Smac mimetics targeting XIAP

Huang Q, Peng Y, Peng Y, Wei D, Wei Y, Feng S

Drug Design, Development and Therapy 2019, 13:1373-1388

Published Date: 26 April 2019

Codelivery of GRP78 siRNA and docetaxel via RGD-PEG-DSPE/DOPA/CaP nanoparticles for the treatment of castration-resistant prostate cancer

Zhang X, He Z, Xiang L, Li L, Zhang H, Lin F, Cao H

Drug Design, Development and Therapy 2019, 13:1357-1372

Published Date: 29 April 2019

Clinical efficacy of 60-mg dexlansoprazole and 40-mg esomeprazole after 24 weeks for the on-demand treatment of gastroesophageal reflux disease grades A and B: a prospective randomized trial

Chiang HH, Wu DC, Hsu PI, Kuo CH, Tai WC, Yang SC, Wu KL, Yao CC, Tsai CE, Liang CM, Wang YK, Wang JW, Huang CF, Chuah SK

Drug Design, Development and Therapy 2019, 13:1347-1356

Published Date: 26 April 2019

Caffeic acid phenethyl ester suppressed growth and metastasis of nasopharyngeal carcinoma cells by inactivating the NF-κB pathway

Liang Y, Feng G, Wu L, Zhong S, Gao X, Tong Y, Cui W, Qin Y, Xu WQ, Xiao X, Zhang Z, Huang G, Zhou X

Drug Design, Development and Therapy 2019, 13:1335-1345

Published Date: 26 April 2019

Epigallocatechin-3-gallate enhances the osteoblastogenic differentiation of human adipose-derived stem cells

Zhang J, Wu K, Xu T, Wu J, Li P, Wang H, Wu H, Wu G

Drug Design, Development and Therapy 2019, 13:1311-1321

Published Date: 23 April 2019

Effects of dezocine for the prevention of postoperative catheter-related bladder discomfort: a prospective randomized trial

Zhang GF, Guo J, Qiu LL, Li SM, Zheng M, Xia JY, Yang JJ

Drug Design, Development and Therapy 2019, 13:1281-1288

Published Date: 23 April 2019

Pharmacokinetics and pharmacodynamics of the novel Nrf2 activator omaveloxolone in primates

Reisman SA, Gahir SS, Lee CY, Proksch JW, Sakamoto M, Ward KW

Drug Design, Development and Therapy 2019, 13:1259-1270

Published Date: 17 April 2019

The molecular mechanisms of Aloin induce gastric cancer cells apoptosis by targeting High Mobility Group Box 1

Tao H, Tang T, Wang S, Wang Z, Ma Y, Cai T, Cheng X, Qi S, Zhang Y, Qi Z

Drug Design, Development and Therapy 2019, 13:1221-1231

Published Date: 17 April 2019

Effect of butorphanol on etomidate-induced myoclonus: a systematic review and meta-analysis

Hua J, Miao S, Shi M, Tu Q, Wang X, Liu S, Wang G, Gan J

Drug Design, Development and Therapy 2019, 13:1213-1220

Published Date: 16 April 2019

Beneficial effects of resveratrol and exercise training on cardiac and aortic function and structure in the 3xTg mouse model of Alzheimer’s disease

Esfandiarei M, Hoxha B, Talley NA, Anderson MR, Alkhouli MF, Squire MA, Eckman DM, Babu JR, Lopaschuk GD, Broderick TL

Drug Design, Development and Therapy 2019, 13:1197-1211

Published Date: 17 April 2019

Tetramethylpyrazine attenuated bupivacaine-induced neurotoxicity in SH-SY5Y cells through regulating apoptosis, autophagy and oxidative damage

Wang S, Xia B, Qiao Z, Duan L, Wang G, Meng W, Liu Z, Wang Y, Zhang M

Drug Design, Development and Therapy 2019, 13:1187-1196

Published Date: 17 April 2019

Effect of umbelliferone on adjuvant-induced arthritis in rats by MAPK/NF-κB pathway

Ouyang L, Dan Y, Shao Z, Yang S, Yang C, Liu G, Zhou W, Duan D

Drug Design, Development and Therapy 2019, 13:1163-1170

Published Date: 11 April 2019

Quizartinib (AC220): a promising option for acute myeloid leukemia

Zhou F, Ge Z, Chen B

Drug Design, Development and Therapy 2019, 13:1117-1125

Published Date: 8 April 2019

A novel hybrid compound LLP2A-alendronate accelerates open fracture healing in a rabbit model

Wang Z, Zhao Y, Zhang D, Qi B, Xiao W, Hu X, Yu A

Drug Design, Development and Therapy 2019, 13:1077-1086

Published Date: 5 April 2019

Systematic elucidation of the mechanism of geraniol via network pharmacology

Zhang YF, Huang Y, Ni YH, Xu ZM

Drug Design, Development and Therapy 2019, 13:1069-1075

Published Date: 4 April 2019

Transportan-derived cell-penetrating peptide delivers siRNA to inhibit replication of influenza virus in vivo

Zhang C, Ren W, Liu Q, Tan Z, Li J, Tong C

Drug Design, Development and Therapy 2019, 13:1059-1068

Published Date: 4 April 2019

Formulation and bioequivalence studies of choline alfoscerate tablet comparing with soft gelatin capsule in healthy male volunteers

Min MH, Park JH, Hur JH, Shin HC, Cho YJ, Kim DD

Drug Design, Development and Therapy 2019, 13:1049-1058

Published Date: 5 April 2019

Metabolism of remimazolam in primary human hepatocytes during continuous long-term infusion in a 3-D bioreactor system

Freyer N, Knöspel F, Damm G, Greuel S, Schneider C, Seehofer D, Stöhr T, Petersen KU, Zeilinger K

Drug Design, Development and Therapy 2019, 13:1033-1047

Published Date: 2 April 2019

Jinlong capsule inhibits migration and invasion in human glioblastoma cells via the modulation of mTOR/S6 signaling pathway

Shi J, Zhang W, He L, Kong F, Pan M, Guo J, Xu X, Guo J, Wang H, Wang Y

Drug Design, Development and Therapy 2019, 13:1023-1032

Published Date: 1 April 2019