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Drug Design, Development and Therapy


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Spotlight on mavrilimumab for the treatment of rheumatoid arthritis: evidence to date

Crotti C, Raimondo MG, Becciolini A, Biggioggero M, Favalli EG

Drug Design, Development and Therapy 2017, 11:211-223

Published Date: 13 January 2017

Comparison of the long-term efficacy and safety of generic Tacrobell with original tacrolimus (Prograf) in kidney transplant recipients

Son SY, Jang HR, Lee JE, Yoo H, Kim K, Park JB, Kim SJ, Oh HY, Huh W

Drug Design, Development and Therapy 2017, 11:203-210

Published Date: 12 January 2017

Computational intelligence models to predict porosity of tablets using minimum features

Khalid MH, Kazemi P, Perez-Gandarillas L, Michrafy A, Szlęk J, Jachowicz R, Mendyk A

Drug Design, Development and Therapy 2017, 11:193-202

Published Date: 12 January 2017

Evaluation of a 2-aminoimidazole variant as adjuvant treatment for dermal bacterial infections

Draughn GL, Allen CL, Routh PA, Stone MR, Kirker KR, Boegli L, Schuchman RM, Linder KE, Baynes RE, James G, Melander C, Pollard A, Cavanagh J

Drug Design, Development and Therapy 2017, 11:153-162

Published Date: 11 January 2017

Pharmacokinetic and pharmacodynamic evaluation according to absorption differences in three formulations of ibuprofen

Shin D, Lee SJ, Ha Y, Choi YS, Kim JW, Park SR, Park MK

Drug Design, Development and Therapy 2017, 11:135-141

Published Date: 4 January 2017

Effects of multiple-dose ponesimod, a selective S1P1 receptor modulator, on lymphocyte subsets in healthy humans

Jurcevic S, Juif PE, Hamid C, Greenlaw R, D'Ambrosio D, Dingemanse J

Drug Design, Development and Therapy 2017, 11:123-131

Published Date: 28 December 2016

Anticancer and anti-inflammatory activities of girinimbine isolated from Murraya koenigii

Iman V, Mohan S, Abdelwahab SI, Karimian H, Nordin N, Fadaeinasab M, Noordin MI, Noor SM

Drug Design, Development and Therapy 2017, 11:103-121

Published Date: 28 December 2016

Vitamin D deficiency and the risk of tuberculosis: a meta-analysis

Huang SJ, Wang XH, Liu ZD, Cao WL, Han Y, Ma AG, Xu SF

Drug Design, Development and Therapy 2017, 11:91-102

Published Date: 28 December 2016

Analysis of pramipexole dose–response relationships in Parkinson's disease

Wang Y, Sun SG, Zhu SQ, Liu CF, Liu YM, Di Q, Shang HF, Ren Y, Xiang W, Chen SD

Drug Design, Development and Therapy 2017, 11:83-89

Published Date: 23 December 2016

Development of a chitosan based double layer-coated tablet as a platform for colon-specific drug delivery

Kim MS, Yeom DW, Kim SR, Yoon HY, Kim CH, Son HY, Kim JH, Lee S, Choi YW

Drug Design, Development and Therapy 2017, 11:45-57

Published Date: 21 December 2016

Spotlight on the 9-valent HPV vaccine

Lopalco PL

Drug Design, Development and Therapy 2017, 11:35-44

Published Date: 20 December 2016

Gastroretentive behavior of orally administered radiolabeled tamarind seed formulations in rabbits validated by gamma scintigraphy

Razavi M, Karimian H, Yeong CH, Fadaeinasab M, Khaing SL, Chung LY, Mohamad Haron DE, Noordin MI

Drug Design, Development and Therapy 2017, 11:1-15

Published Date: 19 December 2016

Folic acid-conjugated amphiphilic alternating copolymer as a new active tumor targeting drug delivery platform

Li X, Szewczuk MR, Malardier-Jugroot C

Drug Design, Development and Therapy 2016, 10:4101-4110

Published Date: 15 December 2016

Structure-based virtual screening and characterization of a novel IL-6 antagonistic compound from synthetic compound database

Wang J, Qiao C, Xiao H, Lin Z, Li Y, Zhang J, Shen B, Fu T, Feng J

Drug Design, Development and Therapy 2016, 10:4091-4100

Published Date: 15 December 2016

Protective effects of vitamin C and vitamin E against hysterosalpingography-induced epithelial degeneration and proliferation in rat endometrium

Pala Ş, Atilgan R, Kuloğlu T, Kara M, Başpınar M, Can B, Artaş G

Drug Design, Development and Therapy 2016, 10:4079-4089

Published Date: 15 December 2016

Design and in vitro/in vivo evaluation of sustained-release floating tablets of itopride hydrochloride

Ahmed SM, Ahmed Ali A, Ali AMA, Hassan OA

Drug Design, Development and Therapy 2016, 10:4061-4071

Published Date: 14 December 2016

Comparison of oral absorption models for pregabalin: usefulness of transit compartment model

Hong T, Han S, Lee J, Jeon S, Yim DS

Drug Design, Development and Therapy 2016, 10:3995-4003

Published Date: 7 December 2016

Impact of prostaglandin glaucoma drops on platelet-activating factor action: an in vitro study

Moschos MM, Nitoda E, Chatziralli IP, Panos GD, Demopoulos CA

Drug Design, Development and Therapy 2016, 10:3977-3981

Published Date: 7 December 2016

Paracetamol sharpens reflection and spatial memory: a double-blind randomized controlled study in healthy volunteers

Pickering G, Macian N, Dubray C, Pereira B

Drug Design, Development and Therapy 2016, 10:3969-3976

Published Date: 5 December 2016

Dose-dependent effects of cisplatin on the severity of testicular injury in Sprague Dawley rats: reactive oxygen species and endoplasmic reticulum stress

Soni KK, Kim HK, Choi BR, Karna KK, You JH, Cha JS, Shin YS, Lee SW, Kim CY, Park JK

Drug Design, Development and Therapy 2016, 10:3959-3968

Published Date: 12 December 2016

Increased therapeutic efficacy of a newly synthesized tyrosinase inhibitor by solid lipid nanoparticles in the topical treatment of hyperpigmentation

Al-Amin M, Cao J, Naeem M, Banna H, Kim M, Jung Y, Chung HY, Moon HR, Yoo J

Drug Design, Development and Therapy 2016, 10:3947-3957

Published Date: 2 December 2016

Loading cisplatin onto 6-mercaptopurine covalently modified MSNS: a nanomedicine strategy to improve the outcome of cisplatin therapy

Lv X, Zhao M, Wang Y, Hu X, Wu J, Jiang X, Li S, Cui C, Peng S

Drug Design, Development and Therapy 2016, 10:3933-3946

Published Date: 1 December 2016

Effect of peritoneal dialysis fluid containing osmo-metabolic agents on human endothelial cells

Bonomini M, Di Silvestre S, Di Tomo P, Di Pietro N, Mandatori D, Di Liberato L, Sirolli V, Chiarelli F, Indiveri C, Pandolfi A, Arduini A

Drug Design, Development and Therapy 2016, 10:3925-3932

Published Date: 28 November 2016

Statistical modeling methods to analyze the impacts of multiunit process variability on critical quality attributes of Chinese herbal medicine tablets

Sun F, Xu B, Zhang Y, Dai SY, Yang C, Cui XL, Shi XY, Qiao YJ

Drug Design, Development and Therapy 2016, 10:3909-3924

Published Date: 28 November 2016

Non-imidazole-based histamine H3 receptor antagonists with anticonvulsant activity in different seizure models in male adult rats

Sadek B, Saad A, Latacz G, Kuder K, Olejarz A, Karcz T, Stark H, Kieć-Kononowicz K

Drug Design, Development and Therapy 2016, 10:3879-3898

Published Date: 25 November 2016

Design, synthesis and evaluation of VEGF-siRNA/CRS as a novel vector for gene delivery

Zhao W, Zhang YF, Jiang XY, Cui CY

Drug Design, Development and Therapy 2016, 10:3851-3865

Published Date: 24 November 2016

Smart nanocrystals of artemether: fabrication, characterization, and comparative in vitro and in vivo antimalarial evaluation

Shah SMH, Ullah F, Khan S, Shah SMM, Matas MD, Hussain Z, Minhas MU, AbdEl-Salam NM, Assi KH, Isreb M

Drug Design, Development and Therapy 2016, 10:3837-3850

Published Date: 24 November 2016

Feasibility of sequential adjuvant chemotherapy with a 3-month oxaliplatin-based regimen followed by 3 months of capecitabine in patients with stage III and high-risk stage II colorectal cancer: JSWOG-C2 study

Tsuruta A, Yamashita K, Tanioka H, Tsuji A, Inukai M, Yamakawa T, Yamatsuji T, Yoshimitsu M, Toyota K, Yamano T, Nagasaka T, Okajima M

Drug Design, Development and Therapy 2016, 10:3827-3835

Published Date: 23 November 2016

Fabrication of anti-vitiligo ointment containing Psoralea corylifolia: in vitro and in vivo characterization

Hussain I, Hussain N, Manan A, Rashid A, Khan B, Bukhsh S

Drug Design, Development and Therapy 2016, 10:3805-3816

Published Date: 22 November 2016

CARD9 as a potential target in cardiovascular disease

Peterson MR, Haller SE, Ren J, Nair S, He G

Drug Design, Development and Therapy 2016, 10:3799-3804

Published Date: 22 November 2016

Comparison of bile salt/phosphatidylcholine mixed micelles in solubilization to sterols and stability

Guo Q, Cai J, Li PY, Xu DL, Ni XM, Wen H, Liu D, Lin SZ, Hu HY

Drug Design, Development and Therapy 2016, 10:3789-3798

Published Date: 17 November 2016

Increased localized delivery of piroxicam by cationic nanoparticles after intra-articular injection

Kim SR, Ho MJ, Kim SH, Cho HR, Kim HS, Choi YS, Choi YW, Kang MJ

Drug Design, Development and Therapy 2016, 10:3779-3787

Published Date: 16 November 2016

Dietary arginine silicate inositol complex inhibits periodontal tissue loss in rats with ligature-induced periodontitis

Dundar S, Eltas A, Hakki SS, Malkoc S, Uslu MO, Tuzcu M, Komorowski J, Ozercan IH, Akdemir F, Sahin K

Drug Design, Development and Therapy 2016, 10:3771-3778

Published Date: 15 November 2016

Pharmacokinetics, pharmacodynamics and safety of CKD-519, a CETP inhibitor, in healthy subjects

Kim CO, Oh ES, Choi CG, Kim YJ, Lee S, Kim S, Park MS

Drug Design, Development and Therapy 2016, 10:3763-3770

Published Date: 15 November 2016

Oncolytic adenovirus expressing interleukin-18 improves antitumor activity of dacarbazine for malignant melanoma

Yang C, Cao H, Liu N, Xu K, Ding M, Mao LJ

Drug Design, Development and Therapy 2016, 10:3755-3761

Published Date: 15 November 2016

Lentivirus-mediated knockdown of NLK inhibits small-cell lung cancer growth and metastasis

Lv MT, Li YM, Tian X, Dai SD, Sun J, Jin GJ, Jiang SY

Drug Design, Development and Therapy 2016, 10:3737-3746

Published Date: 15 November 2016

Systematic review and meta-analysis of randomized controlled trials on Wenxin keli

Wang XY, Wang Y, Feng XY, Lu Y, Zhang Y, Wang WW, Zhu WT

Drug Design, Development and Therapy 2016, 10:3725-3736

Published Date: 14 November 2016

Low-dose modified-release prednisone in axial spondyloarthritis: 3-month efficacy and tolerability

Bandinelli F, Scazzariello F, Pimenta da Fonseca E, Barreto Santiago M, Marcassa C, Nacci F, Matucci Cerinic M

Drug Design, Development and Therapy 2016, 10:3717-3724

Published Date: 14 November 2016

Effects of resveratrol on P-glycoprotein and cytochrome P450 3A in vitro and on pharmacokinetics of oral saquinavir in rats

Li JP, Liu Y, Zhang JR, Yu XT, Wang XL, Zhao LB

Drug Design, Development and Therapy 2016, 10:3699-3706

Published Date: 15 November 2016

Study of the antibacterial and antifungal activities of synthetic benzyl bromides, ketones, and corresponding chalcone derivatives

Shakhatreh MA, Al-Smadi ML, Khabour OF, Shuaibu FA, Hussein EI, Alzoubi KH

Drug Design, Development and Therapy 2016, 10:3653-3660

Published Date: 8 November 2016

Anticonvulsant effects of isomeric nonimidazole histamine H3 receptor antagonists

Sadek B, Saad A, Schwed JS, Weizel L, Walter M, Stark H

Drug Design, Development and Therapy 2016, 10:3633-3651

Published Date: 7 November 2016

Evaluating the cytotoxic effects of the water extracts of four anticancer herbs against human malignant melanoma cells

Ling BB, Michel D, Sakharkar MK, Yang J

Drug Design, Development and Therapy 2016, 10:3563-3572

Published Date: 1 November 2016

Effects of renal function on pharmacokinetics and pharmacodynamics of lesinurad in adult volunteers

Gillen M, Valdez S, Zhou D, Kerr B, Lee CA, Shen Z

Drug Design, Development and Therapy 2016, 10:3555-3562

Published Date: 1 November 2016

Mimetics of brain-derived neurotrophic factor loops 1 and 4 are active in a model of ischemic stroke in rats

Gudasheva TA, Povarnina P, Logvinov IO, Antipova TA, Seredenin SB

Drug Design, Development and Therapy 2016, 10:3545-3553

Published Date: 2 November 2016

Synthesis, anti-inflammatory, analgesic, COX1/2-inhibitory activity, and molecular docking studies of hybrid pyrazole analogues

Alam MJ, Alam O, Khan SA, Naim MJ, Islamuddin M, Deora GS

Drug Design, Development and Therapy 2016, 10:3529-3543

Published Date: 31 October 2016

Supratherapeutic dose evaluation and effect of lesinurad on cardiac repolarization: a thorough QT/QTc study

Shen Z, Gillen M, Tieu K, Nguyen M, Harmon E, Wilson DM, Kerr B, Lee CA

Drug Design, Development and Therapy 2016, 10:3509-3517

Published Date: 27 October 2016

Cardioprotective activity of placental growth factor combined with oral supplementation of L-arginine in a rat model of acute myocardial infarction

Luo L, Chen B, Huang Y, Liang Z, Li S, Yin Y, Chen J, Wu W

Drug Design, Development and Therapy 2016, 10:3483-3492

Published Date: 28 October 2016

Clinical utility of lanreotide Autogel® in gastroenteropancreatic neuroendocrine tumors

Paragliola RM, Prete A, Papi G, Torino F, Corsello A, Pontecorvi A, Corsello SM

Drug Design, Development and Therapy 2016, 10:3459-3470

Published Date: 25 October 2016

α-Aminoadipic acid protects against retinal disruption through attenuating Müller cell gliosis in a rat model of acute ocular hypertension

Wang X, Su J, Ding J, Han S, Ma W, Luo H, Hughes G, Meng Z, Yin Y, Wang Y, Li J

Drug Design, Development and Therapy 2016, 10:3449-3457

Published Date: 20 October 2016

Diminazene aceturate: an antibacterial agent for Shiga-toxin-producing Escherichia coli O157:H7

Wu SY, Park GY, Kim SH, Hulme J, An SSA

Drug Design, Development and Therapy 2016, 10:3363-3378

Published Date: 14 October 2016

Development of a microparticle-based dry powder inhalation formulation of ciprofloxacin hydrochloride applying the quality by design approach

Karimi K, Pallagi E, Szabó-Révész P, Csóka I, Ambrus R

Drug Design, Development and Therapy 2016, 10:3331-3343

Published Date: 12 October 2016

The expression of HoxB5 and SPC in neonatal rat lung at exposure to fluoxetine

Taghizadeh R, Taghipour Z, Karimi A, Shamsizadeh A, Taghavi MM, Shariati M, Shabanizadeh A, Jafari Naveh HR, Bidaki R, Aminzadeh F

Drug Design, Development and Therapy 2016, 10:3323-3329

Published Date: 2 November 2016

Moringin activates Wnt canonical pathway by inhibiting GSK3β in a mouse model of experimental autoimmune encephalomyelitis

Giacoppo S, Soundara Rajan T, De Nicola GR, Iori R, Bramanti P, Mazzon E

Drug Design, Development and Therapy 2016, 10:3291-3304

Published Date: 4 October 2016

Stability of apomorphine in solutions containing selected antioxidant agents

Ang ZY, Boddy M, Liu Y, Sunderland B

Drug Design, Development and Therapy 2016, 10:3253-3265

Published Date: 3 October 2016

Homology modeling, molecular dynamics, and virtual screening of NorA efflux pump inhibitors of Staphylococcus aureus

Bhaskar BV, Babu TMC, Reddy NV, Rajendra W

Drug Design, Development and Therapy 2016, 10:3237-3252

Published Date: 3 October 2016

Spotlight on frovatriptan: a review of its efficacy in the treatment of migraine

Allais G, Benedetto C

Drug Design, Development and Therapy 2016, 10:3225-3236

Published Date: 3 October 2016

Druggability analysis and classification of protein tyrosine phosphatase active sites

Ghattas MA, Raslan N, Sadeq A, Al Sorkhy M, Atatreh N

Drug Design, Development and Therapy 2016, 10:3197-3209

Published Date: 30 September 2016

Looking for inhibitors of the dengue virus NS5 RNA-dependent RNA-polymerase using a molecular docking approach

Galiano V, Garcia-Valtanen P, Micol V, Encinar JA

Drug Design, Development and Therapy 2016, 10:3163-3181

Published Date: 11 October 2016

Incidence and risk of hepatic toxicities with PD-1 inhibitors in cancer patients: a meta-analysis

Zhang X, Ran Y, Wang K, Zhu Y, Li J

Drug Design, Development and Therapy 2016, 10:3153-3161

Published Date: 28 September 2016

Resolvins and aliamides: lipid autacoids in ophthalmology – what promise do they hold?

Hesselink JMK, Chiosi F, Costagliola C

Drug Design, Development and Therapy 2016, 10:3133-3141

Published Date: 27 September 2016

Pharmacokinetics, absorption, and excretion of radiolabeled revexepride: a Phase I clinical trial using a microtracer and accelerator mass spectrometry-based approach

Flach S, Croft M, Ding J, Budhram R, Pankratz T, Pennick M, Scarfe G, Troy S, Getsy J

Drug Design, Development and Therapy 2016, 10:3125-3132

Published Date: 27 September 2016

Structural insights into the polypharmacological activity of quercetin on serine/threonine kinases

Baby B, Antony P, Al Halabi W, Al Homedi Z, Vijayan R

Drug Design, Development and Therapy 2016, 10:3109-3123

Published Date: 27 September 2016

Spotlight on sirukumab for the treatment of rheumatoid arthritis: the evidence to date

Lazzerini PE, Capecchi PL, Guidelli GM, Selvi E, Acampa M, Laghi-Pasini F

Drug Design, Development and Therapy 2016, 10:3083-3098

Published Date: 26 September 2016

Formononetin, an active compound of Astragalus membranaceus (Fisch) Bunge, inhibits hypoxia-induced retinal neovascularization via the HIF-1α/VEGF signaling pathway

Wu J, Ke X, Ma N, Wang W, Fu W, Zhang H, Zhao M, Gao X, Hao X, Zhang Z

Drug Design, Development and Therapy 2016, 10:3071-3081

Published Date: 23 September 2016

Efficacy of an acquainted drug in the treatment of inflammatory low back pain: sulfasalazine under investigation

Moghimi J, Rezaei AA, Ghorbani R, Razavi MR, Pahlevan D

Drug Design, Development and Therapy 2016, 10:3065-3069

Published Date: 23 September 2016

TopBP1 contributes to the chemoresistance in non-small cell lung cancer through upregulation of p53

Lv Y, Huo Y, Yu X, Liu R, Zhang S, Zheng X, Zhang X

Drug Design, Development and Therapy 2016, 10:3053-3064

Published Date: 23 September 2016

Controlled release of TGF-beta 1 from RADA self-assembling peptide hydrogel scaffolds

Zhou A, Chen S, He B, Zhao W, Chen X, Jiang D

Drug Design, Development and Therapy 2016, 10:3043-3051

Published Date: 22 September 2016

Effect of low dose of intrathecal pethidine on the incidence and intensity of shivering during cesarean section under spinal anesthesia: a randomized, placebo-controlled, double-blind clinical trial

Shami S, Nasseri K, Shirmohammadi M, Sarshivi F, Ghadami N, Ghaderi E, Pouladi M, Barzanji A

Drug Design, Development and Therapy 2016, 10:3005-3012

Published Date: 20 September 2016

Profile of adalimumab and its potential in the treatment of uveitis

Balevic SJ, Rabinovich CE

Drug Design, Development and Therapy 2016, 10:2997-3003

Published Date: 19 September 2016

Radiolabeled tirofiban – a potential radiopharmaceutical for detection of deep venous thrombosis

Darkovska-Serafimovska M, Janevik-Ivanovska E, Djorgoski I, Arsova-Sarafinovska Z, Zdravkovska M, Balkanov T, Ugresic N

Drug Design, Development and Therapy 2016, 10:2989-2996

Published Date: 21 September 2016

Combined computational and experimental studies of molecular interactions of albuterol sulfate with bovine serum albumin for pulmonary drug nanoparticles

Lin SH, Cui W, Wang GL, Meng S, Liu YC, Jin HW, Zhang LR, Xie Y

Drug Design, Development and Therapy 2016, 10:2973-2987

Published Date: 15 September 2016

Application of physiologically based pharmacokinetic modeling in predicting drug–drug interactions for sarpogrelate hydrochloride in humans

Min JS, Kim D, Park JB, Heo H, Bae SH, Seo JH, Oh E, Bae SK

Drug Design, Development and Therapy 2016, 10:2959-2972

Published Date: 14 September 2016

A triazole derivative elicits autophagic clearance of polyglutamine aggregation in neuronal cells

Hsieh CH, Lee LC, Leong WY, Yang TC, Yao CF, Fang K

Drug Design, Development and Therapy 2016, 10:2947-2957

Published Date: 14 September 2016

Effects of low-carbohydrate diet therapy in overweight subject with autoimmune thyroiditis: possible synergism with ChREBP

Esposito T, Lobaccaro JM, Esposito MG, Monda V, Messina A, Paolisso G, Varriale B, Monda M, Messina G

Drug Design, Development and Therapy 2016, 10:2939-2946

Published Date: 14 September 2016

Protein kinase C–mediated sodium glucose transporter 1 activation in precondition-induced cardioprotection

Kanwal A, Kasetti S, Putcha UK, Asthana S, Banerjee SK

Drug Design, Development and Therapy 2016, 10:2929-2938

Published Date: 14 September 2016

Effects of an immunosuppressive treatment on the rat prostate

Grabowska M, Kędzierska K, Michałek K, Słuczanowska-Głąbowska S, Grabowski M, Piasecka M, Kram A, Rotter I, Rył A, Laszczyńska M

Drug Design, Development and Therapy 2016, 10:2899-2915

Published Date: 12 September 2016

Understanding cytoskeleton regulators in glioblastoma multiforme for therapy design

Masoumi S, Harisankar A, Gracias A, Bachinger F, Fufa T, Chandrasekar G, Gaunitz F, Walfridsson J, Kitambi SS

Drug Design, Development and Therapy 2016, 10:2881-2897

Published Date: 12 September 2016

Synthesis, solubility, plasma stability, and pharmacological evaluation of novel sulfonylhydrazones designed as anti-diabetic agents

Zapata-Sudo G, da Costa Nunes IK, Araujo JSC, da Silva JS, Trachez MM, da Silva TF, da Costa FP, Sudo RT, Barreiro EJ, Lima LM

Drug Design, Development and Therapy 2016, 10:2869-2879

Published Date: 9 September 2016

In situ delivery of thermosensitive gel-mediated 5-fluorouracil microemulsion for the treatment of colorectal cancer

Wang LL, Huang S, Guo HH, Han YX, Zheng WS, Jiang JD

Drug Design, Development and Therapy 2016, 10:2855-2867

Published Date: 8 September 2016

Downregulation of DOCK1 sensitizes bladder cancer cells to cisplatin through preventing epithelial–mesenchymal transition

Chen D, Chen W, Jiang H, Yang H, Wang Y, Chen J

Drug Design, Development and Therapy 2016, 10:2845-2853

Published Date: 8 September 2016

Eltrombopag for the treatment of aplastic anemia: current perspectives

Lum SH, Grainger JD

Drug Design, Development and Therapy 2016, 10:2833-2843

Published Date: 13 September 2016

Development and in vitro characterization of poly(lactide-co-glycolide) microspheres loaded with an antibacterial natural drug for the treatment of long-term bacterial infections

Reinbold J, Hierlemann T, Hinkel H, Müller I, Maier ME, Weindl T, Schlensak C, Wendel HP, Krajewski S,

Drug Design, Development and Therapy 2016, 10:2823-2832

Published Date: 7 September 2016

Intranasal administration of elastin-like polypeptide for therapeutic delivery to the central nervous system

McGowan JWD, Shao Q, Vig PJS, Bidwell III GL

Drug Design, Development and Therapy 2016, 10:2803-2813

Published Date: 6 September 2016

The use of misoprostol for cervical priming prior to hysteroscopy: a systematic review and analysis

Hua Y, Zhang W, Hu X, Yang A, Zhu X

Drug Design, Development and Therapy 2016, 10:2789-2801

Published Date: 6 September 2016

Two Phase II randomized trials on the CRTh2 antagonist AZD1981 in adults with asthma

Kuna P, Bjermer L, Tornling G

Drug Design, Development and Therapy 2016, 10:2759-2770

Published Date: 31 August 2016

Anti-inflammatory drugs for Duchenne muscular dystrophy: focus on skeletal muscle-releasing factors

Miyatake S, Shimizu-Motohashi Y, Takeda S, Aoki Y

Drug Design, Development and Therapy 2016, 10:2745-2758

Published Date: 30 August 2016

Chloroquine improves left ventricle diastolic function in streptozotocin-induced diabetic mice

Yuan X, Xiao YC, Zhang GP, Hou N, Wu XQ, Chen WL, Luo JD, Zhang GS

Drug Design, Development and Therapy 2016, 10:2729-2737

Published Date: 30 August 2016

Clinical study in genital herpes: natural Gene-Eden-VIR/Novirin versus acyclovir, valacyclovir, and famciclovir

Polansky H, Javaherian A, Itzkovitz E

Drug Design, Development and Therapy 2016, 10:2713-2722

Published Date: 29 August 2016

Nanomedical strategy to prolong survival period, heighten cure rate, and lower systemic toxicity of S180 mice treated with MTX/MIT

Song N, Zhao M, Wang Y, Hu X, Wu J, Jiang X, Li S, Cui C, Peng S

Drug Design, Development and Therapy 2016, 10:2701-2711

Published Date: 30 August 2016

Ticagrelor promotes atherosclerotic plaque stability in a mouse model of advanced atherosclerosis

Preusch MR, Rusnak J, Staudacher K, Mogler C, Uhlmann L, Sievers P, Bea F, Katus HA, Blessing E, Staudacher I

Drug Design, Development and Therapy 2016, 10:2691-2699

Published Date: 26 August 2016

Design, synthesis, and characterization of (1-(4-aryl)-1H-1,2,3-triazol-4-yl)methyl, substituted phenyl-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylates against Mycobacterium tuberculosis

Venugopala KN, Dharma Rao GB, Bhandary S, Pillay M, Chopra D, Aldhubiab BE, Attimarad M, Alwassil OI, Harsha S, Mlisana K

Drug Design, Development and Therapy 2016, 10:2681-2690

Published Date: 25 August 2016

Development of betulinic acid as an agonist of TGR5 receptor using a new in vitro assay

Lo SH, Cheng KC, Li YX, Chang CH, Cheng JT, Lee KS

Drug Design, Development and Therapy 2016, 10:2669-2676

Published Date: 22 August 2016

Effects of alprostadil and iloprost on renal, lung, and skeletal muscle injury following hindlimb ischemia–reperfusion injury in rats

Erer D, Özer A, Demirtaş H, Gönül İI, Kara H, Arpacı H, Çomu FM, Oktar GL, Arslan M, Küçük A

Drug Design, Development and Therapy 2016, 10:2651-2658

Published Date: 19 August 2016

Pharmacokinetic profile of defibrotide in patients with renal impairment

Tocchetti P, Tudone E, Marier JF, Marbury TC, Zomorodi K, Eller M

Drug Design, Development and Therapy 2016, 10:2631-2641

Published Date: 16 August 2016

Novel glyoxalase-I inhibitors possessing a “zinc-binding feature” as potential anticancer agents

Al-Balas QA, Hassan MA, Al-Shar’i NA, Mhaidat NM, Almaaytah AM, Al-Mahasneh FM, Isawi IH

Drug Design, Development and Therapy 2016, 10:2623-2629

Published Date: 17 August 2016

Construction of p66Shc gene interfering lentivirus vectors and its affections on alveolar epithelial cells apoptosis induced by hyperoxia

Zhang C, Dong WB, Zhao S, Li QP, Kang L, Lei XP, Guo L, Zhai XS

Drug Design, Development and Therapy 2016, 10:2611-2622

Published Date: 16 August 2016

Design and characteristics of cytotoxic fibroblast growth factor 1 conjugate for fibroblast growth factor receptor-targeted cancer therapy

Szlachcic A, Zakrzewska M, Lobocki M, Jakimowicz P, Otlewski J

Drug Design, Development and Therapy 2016, 10:2547-2560

Published Date: 9 August 2016

Effects of salvianolate on bone metabolism in glucocorticoid-treated lupus-prone B6.MRL-Faslpr/J mice

Liu Y, Cui Y, Zhang X, Gao X, Su Y, Xu B, Wu T, Chen W, Cui L

Drug Design, Development and Therapy 2016, 10:2535-2546

Published Date: 9 August 2016

Pharmacokinetic and pharmacodynamic interactions between metformin and a novel dipeptidyl peptidase-4 inhibitor, evogliptin, in healthy subjects

Rhee SJ, Choi Y, Lee S, Oh J, Kim SJ, Yoon SH, Cho JY, Yu KS

Drug Design, Development and Therapy 2016, 10:2525-2534

Published Date: 10 August 2016

NAD(P)H:quinone oxidoreductase 1 inducer activity of some novel anilinoquinazoline derivatives

Ghorab MM, Alsaid MS, Higgins M, Dinkova-Kostova AT, Shahat AA, Elghazawy NH, Arafa RK

Drug Design, Development and Therapy 2016, 10:2515-2524

Published Date: 8 August 2016

Endoplasmic reticulum stress-induced autophagy determines the susceptibility of melanoma cells to dabrafenib

Ji C, Zhang ZP, Chen LH, Zhou KL, Li DJ, Wang P, Huang SY, Gong T, Cheng B

Drug Design, Development and Therapy 2016, 10:2491-2498

Published Date: 4 August 2016

Metformin increases pressure pain threshold in lean women with polycystic ovary syndrome

Kiałka M, Milewicz T, Sztefko K, Rogatko I, Majewska R

Drug Design, Development and Therapy 2016, 10:2483-2490

Published Date: 3 August 2016

Effects of lornoxicam and intravenous ibuprofen on erythrocyte deformability and hepatic and renal blood flow in rats

Arpacı H, Çomu FM, Küçük A, Kösem B, Kartal S, Şıvgın V, Turgut HC, Aydın ME, Koç DS, Arslan M

Drug Design, Development and Therapy 2016, 10:2477-2481

Published Date: 3 August 2016

Design of a nanostructured lipid carrier intended to improve the treatment of tuberculosis

Pinheiro M, Ribeiro R, Vieira A, Andrade F, Reis S

Drug Design, Development and Therapy 2016, 10:2467-2475

Published Date: 2 August 2016

Receptor tyrosine kinase (c-Kit) inhibitors: a potential therapeutic target in cancer cells

Abbaspour Babaei M, Kamalidehghan B, Saleem M, Huri HZ, Ahmadipour F

Drug Design, Development and Therapy 2016, 10:2443-2459

Published Date: 1 August 2016

The role of CD147 expression in prostate cancer: a systematic review and meta-analysis

Ye Y, Li SL, Wang Y, Yao Y, Wang J, Ma YY, Hao XK

Drug Design, Development and Therapy 2016, 10:2435-2442

Published Date: 1 August 2016

Flurbiprofen–antioxidant mutual prodrugs as safer nonsteroidal anti-inflammatory drugs: synthesis, pharmacological investigation, and computational molecular modeling

Ashraf Z, Alamgeer, Kanwal M, Hassan M, Abdullah S, Waheed M, Ahsan H, Kim SJ

Drug Design, Development and Therapy 2016, 10:2401-2419

Published Date: 27 July 2016

A review of omalizumab for the management of severe asthma

Lin CH, Cheng SL

Drug Design, Development and Therapy 2016, 10:2369-2378

Published Date: 26 July 2016

Distinct role of the Fas rs1800682 and FasL rs763110 polymorphisms in determining the risk of breast cancer among Han Chinese women

Wang M, Wang Z, Wang XJ, Jin TB, Dai ZM, Kang HF, Guan HT, Ma XB, Liu XH, Dai ZJ

Drug Design, Development and Therapy 2016, 10:2359-2367

Published Date: 25 July 2016

Paclitaxel plus valproic acid versus paclitaxel alone as second- or third-line therapy for advanced gastric cancer: a randomized Phase II trial

Fushida S, Kinoshita J, Kaji M, Oyama K, Hirono Y, Tsukada T, Fujimura T, Ohta T

Drug Design, Development and Therapy 2016, 10:2353-2358

Published Date: 25 July 2016

Novel A20-gene-eluting stent inhibits carotid artery restenosis in a porcine model

Zhou ZH, Peng J, Meng ZY, Chen L, Huang JL, Huang HQ, Li L, Zeng W, Wei Y, Zhu CH, Chen KN

Drug Design, Development and Therapy 2016, 10:2341-2351

Published Date: 8 August 2016

Voiding dysfunction in patients with nasal congestion treated with pseudoephedrine: a prospective study

Shao IH, Wu CC, Tseng HJ, Lee TJ, Lin YH, Tam YY

Drug Design, Development and Therapy 2016, 10:2333-2339

Published Date: 19 July 2016

Prediction of selective estrogen receptor beta agonist using open data and machine learning approach

Niu AQ, Xie LJ, Wang H, Zhu B, Wang SQ

Drug Design, Development and Therapy 2016, 10:2323-2331

Published Date: 18 July 2016

SPOCK1 promotes tumor growth and metastasis in human prostate cancer

Chen Q, Yao YT, Xu H, Chen YB, Gu M, Cai ZK, Wang Z

Drug Design, Development and Therapy 2016, 10:2311-2321

Published Date: 18 July 2016

Rational design and synthesis of novel diphenyl ether derivatives as antitubercular agents

Kar SS, Bhat G V, Rao PP, Shenoy VP, Bairy I, Shenoy GG

Drug Design, Development and Therapy 2016, 10:2299-2310

Published Date: 18 July 2016

Galeterone for the treatment of advanced prostate cancer: the evidence to date

Bastos DA, Antonarakis ES

Drug Design, Development and Therapy 2016, 10:2289-2297

Published Date: 15 July 2016

The influence of intrauterine exposure to immunosuppressive treatment on changes in the immune system in juvenile Wistar rats

Kabat-Koperska J, Kolasa-Wołosiuk A, Wojciuk B, Wojciechowska-Koszko I, Roszkowska P, Krasnodębska-Szponder B, Paczkowska E, Safranow K, Gołembiewska E, Machaliński B, Ciechanowski K

Drug Design, Development and Therapy 2016, 10:2279-2288

Published Date: 14 July 2016

Simvastatin attenuates radiation-induced salivary gland dysfunction in mice

Xu L, Yang X, Chen J, Ge X, Qin Q, Zhu H, Zhang C, Sun X

Drug Design, Development and Therapy 2016, 10:2271-2278

Published Date: 13 July 2016

Thymoquinone subdues tumor growth and potentiates the chemopreventive effect of 5-fluorouracil on the early stages of colorectal carcinogenesis in rats

Kensara OA, El-Shemi AG, Mohamed AM, Refaat B, Idris S, Ahmad J

Drug Design, Development and Therapy 2016, 10:2239-2253

Published Date: 11 July 2016

Pharmacogenetic analysis of cinacalcet response in secondary hyperparathyroidism patients

Jeong S, Kim IW, Oh KH, Han N, Joo KW, Kim HJ, Oh JM

Drug Design, Development and Therapy 2016, 10:2211-2225

Published Date: 8 July 2016

Acyl lipidation of a peptide: effects on activity and epidermal permeability in vitro

Rocco D, Ross J, Murray PE, Caccetta R

Drug Design, Development and Therapy 2016, 10:2203-2209

Published Date: 8 July 2016

Rosmarinic acid ameliorates hyperglycemia and insulin sensitivity in diabetic rats, potentially by modulating the expression of PEPCK and GLUT4

Runtuwene J, Cheng KC, Asakawa A, Amitani H, Amitani M, Morinaga A, Takimoto Y, Kairupan BHR, Inui A

Drug Design, Development and Therapy 2016, 10:2193-2202

Published Date: 7 July 2016

Effect of N-methyl deuteration on metabolism and pharmacokinetics of enzalutamide

Jiang J, Pang X, Li L, Dai X, Diao X, Chen X, Zhong D, Wang Y, Chen Y

Drug Design, Development and Therapy 2016, 10:2181-2191

Published Date: 7 July 2016

The effects of ferulic acid on the pharmacokinetics of warfarin in rats after biliary drainage

Li H, Wang Y, Fan R, Lv H, Sun H, Xie H, Tang T, Luo J, Xia Z

Drug Design, Development and Therapy 2016, 10:2173-2180

Published Date: 6 July 2016

Cabozantinib in the treatment of advanced renal cell carcinoma: design, development, and potential place in the therapy

Grassi P, Verzoni E, Ratta R, Mennitto A, de Braud F, Procopio G

Drug Design, Development and Therapy 2016, 10:2167-2172

Published Date: 5 July 2016

Real-time monitoring of cisplatin cytotoxicity on three-dimensional spheroid tumor cells

Baek NH, Seo OW, Lee J, Hulme J, An SSA

Drug Design, Development and Therapy 2016, 10:2155-2165

Published Date: 4 July 2016

Pharmacophore modeling and in silico toxicity assessment of potential anticancer agents from African medicinal plants

Ntie-Kang F, Simoben CV, Karaman B, Ngwa VF, Judson PN, Sippl W, Mbaze LM

Drug Design, Development and Therapy 2016, 10:2137-2154

Published Date: 4 July 2016

Clinical implications for substandard, nonproprietary medicines in multiple sclerosis: focus on fingolimod

Correale J, Chiquete E, Boyko A, Beran RG, Strauch JB, Milojevic S, Frider N

Drug Design, Development and Therapy 2016, 10:2109-2117

Published Date: 30 June 2016

Sitagliptin attenuates cardiomyopathy by modulating the JAK/STAT signaling pathway in experimental diabetic rats

Al-Rasheed NM, Al-Rasheed NM, Hasan IH, Al-Amin MA, Al-Ajmi HN, Mahmoud AM

Drug Design, Development and Therapy 2016, 10:2095-2107

Published Date: 28 June 2016

Golimumab in radiographic and nonradiographic axial spondyloarthritis: a review of clinical trials

Toussirot E, Vauchy C, Binda D, Michel F

Drug Design, Development and Therapy 2016, 10:2087-2094

Published Date: 1 July 2016

Dietary arginine silicate inositol complex increased bone healing: histologic and histomorphometric study

Yaman F, Acikan I, Dundar S, Simsek S, Gul M, Ozercan İH, Komorowski J, Sahin K

Drug Design, Development and Therapy 2016, 10:2081-2086

Published Date: 27 June 2016

Secukinumab for rheumatology: development and its potential place in therapy

Koenders MI, van den Berg WB

Drug Design, Development and Therapy 2016, 10:2069-2080

Published Date: 24 June 2016

The cytotoxicity study of praziquantel enantiomers

Sun Q, Mao RF, Wang DL, Hu CY, Zheng Y, Sun DQ

Drug Design, Development and Therapy 2016, 10:2061-2068

Published Date: 24 June 2016

Anti-dengue drug: viral polyprotein, a potential target

Mahmood SU, Mushtaq M, Syed MJ

Drug Design, Development and Therapy 2016, 10:2047-2048

Published Date: 24 June 2016

Fondaparinux vs warfarin for the treatment of unsuspected pulmonary embolism in cancer patients

Amato B, Compagna R, Rocca A, Bianco T, Milone M, Sivero L, Vigliotti G, Amato M, Danzi M, Aprea G, Gallelli L, de Franciscis S, Serra R

Drug Design, Development and Therapy 2016, 10:2041-2046

Published Date: 23 June 2016

A novel pH–enzyme-dependent mesalamine colon-specific delivery system

Jin L, Ding Y, Zhang Y, Xu X, Cao Q

Drug Design, Development and Therapy 2016, 10:2021-2028

Published Date: 20 June 2016

MART-10, a newly synthesized vitamin D analog, represses metastatic potential of head and neck squamous carcinoma cells

Yang SW, Tsai CY, Pan YC, Yeh CN, Pang JHS, Takano M, Kittaka A, Juang HH, Chen TC, Chiang KC

Drug Design, Development and Therapy 2016, 10:1995-2002

Published Date: 17 June 2016

Double-blind, randomized, double-dummy clinical trial comparing the efficacy of ketorolac trometamol and naproxen for acute low back pain

Plapler PG, Scheinberg MA, Ecclissato CC, Bocchi de Oliveira MF, Amazonas RB

Drug Design, Development and Therapy 2016, 10:1987-1993

Published Date: 17 June 2016

Prophylactic effects of Clausena excavata Burum. f. leaf extract in ethanol-induced gastric ulcers

Albaayit SFA, Abba Y, Abdullah R, Abdullah N

Drug Design, Development and Therapy 2016, 10:1973-1986

Published Date: 15 June 2016

Efficacy and safety of gemcitabine plus erlotinib for locally advanced or metastatic pancreatic cancer: a systematic review and meta-analysis

Wang Y, Hu GF, Zhang QQ, Tang N, Guo J, Liu LY, Han X, Wang X, Wang ZH

Drug Design, Development and Therapy 2016, 10:1961-1972

Published Date: 13 June 2016

A novel imidazopyridine derivative, X22, attenuates sepsis-induced lung and liver injury by inhibiting the inflammatory response in vitro and in vivo

Ge X, Feng Z, Xu T, Wu B, Chen H, Xu F, Fu L, Shan X, Dai Y, Zhang Y, Liang G

Drug Design, Development and Therapy 2016, 10:1947-1959

Published Date: 24 June 2016

The efficacy of nebulized magnesium sulfate alone and in combination with salbutamol in acute asthma

Sarhan HA, EL-Garhy OH, Ali MA, Youssef NA

Drug Design, Development and Therapy 2016, 10:1927-1933

Published Date: 9 June 2016

In vivo gastric residence and gastroprotective effect of floating gastroretentive tablet of DA-9601, an extract of Artemisia asiatica, in beagle dogs

Kim JS, Cha KH, Kang SY, Won D, Jang SW, Son M, Son MH, Choi HJ, Lee YW, Kang MJ

Drug Design, Development and Therapy 2016, 10:1917-1925

Published Date: 9 June 2016

Role of cytochrome P450 2D6 genetic polymorphism in carvedilol hydroxylation in vitro

Wang Z, Wang L, Xu RA, Zhan YY, Huang CK, Dai DP, Cai JP, Hu GX

Drug Design, Development and Therapy 2016, 10:1909-1916

Published Date: 8 June 2016

Flavokawain derivative FLS induced G2/M arrest and apoptosis on breast cancer MCF-7 cell line

Ali NM, Akhtar MN, Ky H, Lim KL, Abu N, Zareen S, Ho WY, Alan-Ong HK, Tan SW, Alitheen NB, Ismail JB, Yeap SK, Kamarul T

Drug Design, Development and Therapy 2016, 10:1897-1907

Published Date: 10 June 2016

Molecular mechanisms of cisplatin resistance in cervical cancer

Zhu H, Luo H, Zhang W, Shen Z, Hu X, Zhu X

Drug Design, Development and Therapy 2016, 10:1885-1895

Published Date: 7 June 2016

Erythropoietin ameliorates hyperglycemia in type 1-like diabetic rats

Niu HS, Chang CH, Niu CS, Cheng JT, Lee KS

Drug Design, Development and Therapy 2016, 10:1877-1884

Published Date: 3 June 2016

Indigofera oblongifolia mitigates lead-acetate-induced kidney damage and apoptosis in a rat model

Dkhil MA, Al-Khalifa MS, Al-Quraishy S, Zrieq R, Abdel Moneim AE

Drug Design, Development and Therapy 2016, 10:1847-1856

Published Date: 2 June 2016

Nelfinavir is effective against human cervical cancer cells in vivo: a potential treatment modality in resource-limited settings

Davis MA, Delaney JR, Patel CB, Storgard R, Stupack DG

Drug Design, Development and Therapy 2016, 10:1837-1846

Published Date: 2 June 2016

Synthesis, activity, and docking study of phenylthiazole acids as potential agonists of PPARγ

Ma L, Wang T, Shi M, Ye H

Drug Design, Development and Therapy 2016, 10:1807-1815

Published Date: 30 May 2016

The arsenal of pathogens and antivirulence therapeutic strategies for disarming them

Brannon JR, Hadjifrangiskou M

Drug Design, Development and Therapy 2016, 10:1795-1806

Published Date: 27 May 2016

An open-label clinical trial of agalsidase alfa enzyme replacement therapy in children with Fabry disease who are naïve to enzyme replacement therapy

Goker-Alpan O, Longo N, McDonald M, Shankar SP, Schiffmann R, Chang P, Shen Y, Pano A

Drug Design, Development and Therapy 2016, 10:1771-1781

Published Date: 25 May 2016

Apremilast in the therapy of moderate-to-severe chronic plaque psoriasis

Gisondi P, Girolomoni G

Drug Design, Development and Therapy 2016, 10:1763-1770

Published Date: 25 May 2016

Activity of a novel sulfonamide compound 2-nitro-N-(pyridin-2-ylmethyl)benzenesulfonamide against Leishmania donovani

Dikhit MR, Purkait B, Singh R, Sahoo BR, Kumar A, Kar RK, Ansari MY, Saini S, Abhishek K, Sahoo GC, Das S, Das P

Drug Design, Development and Therapy 2016, 10:1753-1761

Published Date: 26 May 2016

Sulfasalazine inhibits inflammation and fibrogenesis in pancreas via NF-κB signaling pathway in rats with oxidative stress-induced pancreatic injury

Wang YR, Tian FL, Yan MX, Fan JH, Wang LY, Kuang RG, Li YQ

Drug Design, Development and Therapy 2016, 10:1743-1751

Published Date: 24 May 2016

Computer-aided vaccine designing approach against fish pathogens Edwardsiella tarda and Flavobacterium columnare using bioinformatics softwares

Mahendran R, Jeyabaskar S, Sitharaman G, Michael RD, Paul AV

Drug Design, Development and Therapy 2016, 10:1703-1714

Published Date: 23 May 2016

Electroporation-delivered transdermal neostigmine in rats: equivalent action to intravenous administration

Berkó S, Szűcs KF, Balázs B, Csányi E, Varju G, Sztojkov-Ivanov A, Budai-Szűcs M, Bóta J, Gáspár R

Drug Design, Development and Therapy 2016, 10:1695-1701

Published Date: 19 May 2016

Safety, tolerability, pharmacokinetics, and pharmacodynamics of novel glucokinase activator HMS5552: results from a first-in-human single ascending dose study

Xu HR, Sheng L, Chen WL, Yuan F, Yang MJ, Li H, Li XN, Choi J, Zhao GY, Hu TX, Li YG, Zhang Y, Chen L

Drug Design, Development and Therapy 2016, 10:1619-1626

Published Date: 9 May 2016

Effectiveness, durability, and safety of darunavir/ritonavir in HIV-1-infected patients in routine clinical practice in Italy: a postauthorization noninterventional study

Antinori A, Meraviglia P, d’Arminio Monforte A, Castagna A, Mussini C, Bini T, Gianotti N, Rusconi S, Colella E, Airoldi G, Mancusi D, Termini R

Drug Design, Development and Therapy 2016, 10:1589-1603

Published Date: 6 May 2016

Fimasartan for independent reduction of blood pressure variability in mild-to-moderate hypertension

Shin MS, Kang DR, Kim C, Cho EJ, Sung KC, Kang SM, Kim DS, Joo SJ, Lee SH, Hwang KK, Park JB

Drug Design, Development and Therapy 2016, 10:1573-1580

Published Date: 5 May 2016

Fungistatic activity of all-trans retinoic acid against Aspergillus fumigatus and Candida albicans

Campione E, Gaziano R, Marino D, Orlandi A

Drug Design, Development and Therapy 2016, 10:1551-1555

Published Date: 29 April 2016

The influence of dietary sodium content on the pharmacokinetics and pharmacodynamics of fimasartan

Gu N, Cho JY, Shin KH, Jang IJ, Rhee MY

Drug Design, Development and Therapy 2016, 10:1525-1531

Published Date: 19 April 2016

Autophagy inhibition enhances RAD001-induced cytotoxicity in human bladder cancer cells

Lin JF, Lin YC, Yang SC, Tsai TF, Chen HE, Chou KY, Hwang TIS

Drug Design, Development and Therapy 2016, 10:1501-1513

Published Date: 18 April 2016

Design, synthesis, and biological evaluation of 3-vinyl-quinoxalin-2(1H)-one derivatives as novel antitumor inhibitors of FGFR1

Liu Z, Yu S, Chen D, Shen G, Wang Y, Hou L, Lin D, Zhang JS, Ye F

Drug Design, Development and Therapy 2016, 10:1489-1500

Published Date: 3 May 2016

Neuroprotective effect of β-asarone against Alzheimer’s disease: regulation of synaptic plasticity by increased expression of SYP and GluR1

Liu SJ, Yang C, Zhang Y, Su RY, Chen JL, Jiao MM, Chen HF, Zheng N, Luo S, Chen YB, Quan SJ, Wang Q

Drug Design, Development and Therapy 2016, 10:1461-1469

Published Date: 15 April 2016

Zoledronate upregulates MMP-9 and -13 in rat vascular smooth muscle cells by inducing oxidative stress

Arun MZ, Reel B, Sala-Newby GB, Bond M, Tsaousi A, Maskell P, Newby AC

Drug Design, Development and Therapy 2016, 10:1453-1460

Published Date: 18 April 2016

Xyloketal-derived small molecules show protective effect by decreasing mutant Huntingtin protein aggregates in Caenorhabditis elegans model of Huntington’s disease

Zeng YX, Guo WY, Xu GQ, Wang QM, Feng LY, Long SM, Liang FY, Huang Y, Lu XL, Li SC, Zhou JB, Burgunder JM, Pang JY, Pei Z

Drug Design, Development and Therapy 2016, 10:1443-1451

Published Date: 13 April 2016

Baicalein suppresses metastasis of breast cancer cells by inhibiting EMT via downregulation of SATB1 and Wnt/β-catenin pathway

Ma X, Yan W, Dai Z, Gao X, Ma Y, Xu Q, Jiang J, Zhang S

Drug Design, Development and Therapy 2016, 10:1419-1441

Published Date: 18 April 2016

Functionalized D-form self-assembling peptide hydrogels for bone regeneration

He B, Ou Y, Zhou A, Chen S, Zhao W, Zhao J, Li H, Zhu Y, Zhao Z, Jiang D

Drug Design, Development and Therapy 2016, 10:1379-1388

Published Date: 11 April 2016

Neuroprotective effects of salidroside through PI3K/Akt pathway activation in Alzheimer’s disease models

Zhang B, Wang Y, Li H, Xiong R, Zhao Z, Chu X, Li Q, Sun S, Chen S

Drug Design, Development and Therapy 2016, 10:1335-1343

Published Date: 6 April 2016

Identification of new drug candidates against Borrelia burgdorferi using high-throughput screening

Pothineni VR, Wagh D, Babar MM, Inayathullah M, Solow-Cordero DE, Kim KM, Samineni AV, Parekh MB, Tayebi L, Rajadas J

Drug Design, Development and Therapy 2016, 10:1307-1322

Published Date: 1 April 2016

In vitro and in vivo efficacy of afatinib as a single agent or in combination with gemcitabine for the treatment of nasopharyngeal carcinoma

Xue C, Tian Y, Zhang J, Zhao YY, Zhan JH, Fang WF, Zhang L

Drug Design, Development and Therapy 2016, 10:1299-1306

Published Date: 31 March 2016

Curcumin protects against myocardial infarction-induced cardiac fibrosis via SIRT1 activation in vivo and in vitro

Xiao J, Sheng X, Zhang X, Guo M, Ji X

Drug Design, Development and Therapy 2016, 10:1267-1277

Published Date: 29 March 2016

Comparative efficacy of tamsulosin versus nifedipine for distal ureteral calculi: a meta-analysis

Wang H, Man LB, Huang GL, Li GZ, Wang JW

Drug Design, Development and Therapy 2016, 10:1257-1265

Published Date: 29 March 2016

Zolav®: a new antibiotic for the treatment of acne

Dinant A, Boulos RA

Drug Design, Development and Therapy 2016, 10:1235-1242

Published Date: 22 March 2016

The renoprotective effects of sulodexide

Olde Engberink RH, Vogt L

Drug Design, Development and Therapy 2016, 10:1233-1234

Published Date: 22 March 2016

Role of glycogen synthase kinase-3β inhibitor AZD1080 in ovarian cancer

Chen S, Sun KX, Feng MX, Sang XB, Liu BL, Zhao Y

Drug Design, Development and Therapy 2016, 10:1225-1232

Published Date: 18 March 2016

Effects of acute and chronic administration of neurosteroid dehydroepiandrosterone sulfate on neuronal excitability in mice

Svob Strac D, Vlainic J, Samardzic J, Erhardt J, Krsnik Z

Drug Design, Development and Therapy 2016, 10:1201-1215

Published Date: 21 March 2016

Computational and nonglycosylated systems: a simpler approach for development of nanosized PEGylated proteins

Mirzaei H, Kazemi B, Bandehpour M, Shoari A, Asgary V, Ardestani MS, Madadkar-Sobhani A, Ahangari Cohan R

Drug Design, Development and Therapy 2016, 10:1193-1200

Published Date: 16 March 2016

Efficacy of BIBF 1120 or BIBF 1120 plus chemotherapy on nasopharyngeal carcinoma in vitro and in vivo

Xue C, Tian Y, Zhang J, Zhao Y, Zhan J, Fang W, Zhang L

Drug Design, Development and Therapy 2016, 10:1173-1180

Published Date: 15 March 2016

Toward antituberculosis drugs: in silico screening of synthetic compounds against Mycobacterium tuberculosis L,D-transpeptidase 2

Billones JB, Carrillo MCO, Organo VG, Macalino SJY, Sy JBA, Emnacen IA, Clavio NAB, Concepcion GP

Drug Design, Development and Therapy 2016, 10:1147-1157

Published Date: 11 March 2016

Synthesis, antimicrobial, and antiproliferative activities of substituted phenylfuranylnicotinamidines

Youssef MM, Arafa RK, Ismail MA,

Drug Design, Development and Therapy 2016, 10:1133-1146

Published Date: 11 March 2016

Selective use of sorafenib in the treatment of thyroid cancer

Pitoia F, Jerkovich F

Drug Design, Development and Therapy 2016, 10:1119-1131

Published Date: 11 March 2016

Formulation and clinical evaluation of silymarin pluronic-lecithin organogels for treatment of atopic dermatitis

Mady FM, Essa H, El-Ammawi T, Abdelkader H, Hussein AK

Drug Design, Development and Therapy 2016, 10:1101-1110

Published Date: 10 March 2016

Protective effects of honokiol on ischemia/reperfusion injury of rat ovary: an experimental study

Yaman Tunc S, Agacayak E, Goruk NY, Icen MS, Turgut A, Alabalik U, Togrul C, Ekinci C, Ekinci A, Gul T

Drug Design, Development and Therapy 2016, 10:1077-1083

Published Date: 8 March 2016

RGD(F/S/V)-Dex: towards the development of novel, effective, and safe glucocorticoids

Jiang X, Zhao M, Wang Y, Zhu H, Zhao S, Wu J, Song Y, Peng S

Drug Design, Development and Therapy 2016, 10:1059-1076

Published Date: 8 March 2016

Chloroquine enhances the efficacy of cisplatin by suppressing autophagy in human adrenocortical carcinoma treatment

Qin L, Xu TY, Xia LL, Wang XJ, Zhang X, Zhang XH, Zhu ZW, Zhong S, Wang CD, Shen ZJ

Drug Design, Development and Therapy 2016, 10:1035-1045

Published Date: 7 March 2016

Stability studies of lincomycin hydrochloride in aqueous solution and intravenous infusion fluids

Czarniak P, Boddy M, Sunderland B, Hughes JD

Drug Design, Development and Therapy 2016, 10:1029-1034

Published Date: 7 March 2016

Amsacrine analog-loaded solid lipid nanoparticle to resolve insolubility for injection delivery: characterization and pharmacokinetics

Fang YP, Chuang CH, Wu PC, Huang YB, Tzeng CC, Chen YL, Liu YT, Tsai YH, Tsai MJ

Drug Design, Development and Therapy 2016, 10:1019-1028

Published Date: 4 March 2016

Plasmodium-infected erythrocytes (pRBC) induce endothelial cell apoptosis via a heme-mediated signaling pathway

Liu M, Dickinson-Copeland C, Hassana S, Stiles JK

Drug Design, Development and Therapy 2016, 10:1009-1018

Published Date: 3 March 2016

Da0324, an inhibitor of nuclear factor-κB activation, demonstrates selective antitumor activity on human gastric cancer cells

Jin R, Xia Y, Chen Q, Li W, Chen D, Ye H, Zhao C, Du X, Shi D, Wu J, Liang G

Drug Design, Development and Therapy 2016, 10:979-995

Published Date: 2 March 2016

Eucommia bark (Du-Zhong) improves diabetic nephropathy without altering blood glucose in type 1-like diabetic rats

Niu HS, Liu IM, Niu CS, Ku PM, Hsu CT, Cheng JT

Drug Design, Development and Therapy 2016, 10:971-978

Published Date: 2 March 2016

Solubility enhancement of simvastatin by arginine: thermodynamics, solute–solvent interactions, and spectral analysis

Meor Mohd Affandi MMR, Tripathy M, Shah SAA, Majeed ABA

Drug Design, Development and Therapy 2016, 10:959-969

Published Date: 2 March 2016

Effects of Dang-Gui-Bu-Xue-Tang, an herbal decoction, on iron uptake in iron-deficient anemia

Huang GC, Chen SY, Tsai PW, Ganzon JG, Lee CJ, Shiah HS, Wang CC

Drug Design, Development and Therapy 2016, 10:949-957

Published Date: 2 March 2016

Effect of picroside II on erythrocyte deformability and lipid peroxidation in rats subjected to hind limb ischemia reperfusion injury

Çomu FM, Kılıç Y, Özer A, Kirişçi M, Dursun AD, Tatar T, Zor MH, Kartal H, Küçük A, Boyunağa H, Arslan M

Drug Design, Development and Therapy 2016, 10:927-931

Published Date: 1 March 2016

Naringenin-loaded solid lipid nanoparticles: preparation, controlled delivery, cellular uptake, and pulmonary pharmacokinetics

Ji P, Yu T, Liu Y, Jiang J, Xu J, Zhao Y, Hao Y, Qiu Y, Zhao W, Wu C

Drug Design, Development and Therapy 2016, 10:911-925

Published Date: 1 March 2016

The aqueous extract of Glycyrrhiza inflata can upregulate unfolded protein response-mediated chaperones to reduce tau misfolding in cell models of Alzheimer’s disease

Chang KH, Chen IC, Lin HY, Chen HC, Lin CH, Lin TH, Weng YT, Chao CY, Wu YR, Lin JY, Lee-Chen GJ, Chen CM

Drug Design, Development and Therapy 2016, 10:885-896

Published Date: 29 February 2016

Spotlight on lenvatinib in the treatment of thyroid cancer: patient selection and perspectives

Costa R, Carneiro BA, Chandra S, Pai SG, Chae YK, Kaplan JB, Garrett HB, Agulnik M, Kopp PA, Giles FJ

Drug Design, Development and Therapy 2016, 10:873-884

Published Date: 29 February 2016

The interplay of post-translational modification and gene therapy

Osamor VC, Chinedu SN, Azuh DE, Iweala EJ, Ogunlana OO

Drug Design, Development and Therapy 2016, 10:861-871

Published Date: 29 February 2016

Papaverine inhibits lipopolysaccharide-induced microglial activation by suppressing NF-κB signaling pathway

Dang Y, Mu Y, Wang K, Xu K, Yang J, Zhu Y, Luo B

Drug Design, Development and Therapy 2016, 10:851-859

Published Date: 26 February 2016

The mechanism underlying alpinetin-mediated alleviation of pancreatitis-associated lung injury through upregulating aquaporin-1

Liang XS, Zhang B, Chen Q, Zhang J, Lei B, Li B, Wei YC, Zhai R, Liang ZQ, He SQ, Tang B

Drug Design, Development and Therapy 2016, 10:841-850

Published Date: 24 February 2016

Total saponin of Dioscoreae hypoglaucae rhizoma ameliorates streptozotocin-induced diabetic nephropathy

Guo C, Ding G, Huang W, Wang Z, Meng Z, Xiao W

Drug Design, Development and Therapy 2016, 10:799-810

Published Date: 24 February 2016

Synergistic roles of p53 and HIF1α in human renal cell carcinoma-cell apoptosis responding to the inhibition of mTOR and MDM2 signaling pathways

Liu QJ, Shen HL, Lin J, Xu XH, Ji ZG, Han X, Shang DH, Yang PQ

Drug Design, Development and Therapy 2016, 10:745-755

Published Date: 18 February 2016

A network pharmacology approach to discover active compounds and action mechanisms of San-Cao Granule for treatment of liver fibrosis

Wei S, Niu M, Wang J, Wang J, Su H, Luo S, Zhang X, Guo Y, Liu L, Liu F, Zhao Q, Chen H, Xiao X, Zhao P, Zhao Y

Drug Design, Development and Therapy 2016, 10:733-743

Published Date: 19 February 2016

Treatment with a Ginkgo biloba extract, EGb 761, inhibits excitotoxicity in an animal model of spinocerebellar ataxia type 17

Huang DS, Lin HY, Lee-Chen GJ, Hsieh-Li HM, Wu CH, Lin JY

Drug Design, Development and Therapy 2016, 10:723-731

Published Date: 18 February 2016

Effects of 22 novel CYP2D6 variants found in Chinese population on the metabolism of dapoxetine

Xu RA, Gu EM, Zhou Q, Yuan LJ, Hu XX, Cai JP, Hu GX

Drug Design, Development and Therapy 2016, 10:687-696

Published Date: 15 February 2016

Long-term use of amiodarone before heart transplantation significantly reduces early post-transplant atrial fibrillation and is not associated with increased mortality after heart transplantation

Rivinius R, Helmschrott M, Ruhparwar A, Schmack B, Erbel C, Gleissner CA, Akhavanpoor M, Frankenstein L, Darche FF, Schweizer PA, Thomas D, Ehlermann P, Bruckner T, Katus HA, Doesch AO

Drug Design, Development and Therapy 2016, 10:677-686

Published Date: 16 February 2016

Drug-loaded erythrocytes: on the road toward marketing approval

Bourgeaux V, Lanao JM, Bax BE, Godfrin Y

Drug Design, Development and Therapy 2016, 10:665-676

Published Date: 11 February 2016

Therapeutic effects of tyroservatide on metastasis of lung cancer and its mechanism affecting integrin–focal adhesion kinase signal transduction

Huang YT, Zhao L, Fu Z, Zhao M, Song XM, Jia J, Wang S, Li JP, Zhu ZF, Lin G, Lu R, Yao Z

Drug Design, Development and Therapy 2016, 10:649-663

Published Date: 3 March 2016

Epigallocatechin-3-gallate attenuates apoptosis and autophagy in concanavalin A-induced hepatitis by inhibiting BNIP3

Li S, Xia Y, Chen K, Li J, Liu T, Wang F, Lu J, Zhou Y, Guo C

Drug Design, Development and Therapy 2016, 10:631-647

Published Date: 15 February 2016

Protective effect of fucoidan from Fucus vesiculosus on liver fibrosis via the TGF-β1/Smad pathway-mediated inhibition of extracellular matrix and autophagy

Li J, Chen K, Li S, Feng J, Liu T, Wang F, Zhang R, Xu S, Zhou Y, Zhou S, Xia Y, Lu J, Zhou Y, Guo C

Drug Design, Development and Therapy 2016, 10:619-630

Published Date: 12 February 2016

Adjuvant therapies for Parkinson’s disease: critical evaluation of safinamide

Stocchi F, Torti M

Drug Design, Development and Therapy 2016, 10:609-618

Published Date: 5 February 2016

Randomized clinical trial: pharmacokinetics and safety of multimatrix mesalamine for treatment of pediatric ulcerative colitis

Cuffari C, Pierce D, Korczowski B, Fyderek K, Van Heusen H, Hossack S, Wan H, Edwards AY, Martin P

Drug Design, Development and Therapy 2016, 10:593-607

Published Date: 4 February 2016

Establishment of a novel therapeutic vector targeting the trigeminal ganglion in rats

Xu K, Pan SY, Song JX, ,Liu XN, An N, Zheng X

Drug Design, Development and Therapy 2016, 10:585-592

Published Date: 4 February 2016

miR-125b acts as a tumor suppressor in chondrosarcoma cells by the sensitization to doxorubicin through direct targeting the ErbB2-regulated glucose metabolism

Tang XY, Zheng W, Ding M, Guo KJ, Yuan F, Feng H, Deng B, Sun W, Hou Y, Gao L

Drug Design, Development and Therapy 2016, 10:571-583

Published Date: 24 February 2016

Curcumin enhances the cytogenotoxic effect of etoposide in leukemia cells through induction of reactive oxygen species

Papież MA, Krzyściak W, Szade K, Bukowska-Straková K, Kozakowska M, Hajduk K, Bystrowska B, Dulak J, Jozkowicz A

Drug Design, Development and Therapy 2016, 10:557-570

Published Date: 4 February 2016

Targeting the D1-N-methyl-D-aspartate receptor complex reduces L-dopa-induced dyskinesia in 6-hydroxydopamine-lesioned Parkinson’s rats

Song L, Zhang ZZ, Hu RG, Cheng J, Li L, Fan QY, Wu N, Gan J, Zhou MZ, Liu ZG

Drug Design, Development and Therapy 2016, 10:547-555

Published Date: 3 February 2016

Antiviral therapy: a perspective

Shahidi Bonjar AH

Drug Design, Development and Therapy 2016, 10:541-546

Published Date: 2 February 2016

Preparation and characterization of silymarin synchronized-release microporous osmotic pump tablets

Zeng QP, Liu ZH, Huang AW, Zhang J, Song HT

Drug Design, Development and Therapy 2016, 10:519-531

Published Date: 29 January 2016

Determination of the binding mode for anti-inflammatory natural product xanthohumol with myeloid differentiation protein 2

Fu W, Chen L, Wang Z, Zhao C, Chen G, Liu X, Dai Y, Cai Y, Li C, Zhou J, Liang G

Drug Design, Development and Therapy 2016, 10:455-463

Published Date: 27 January 2016

Amelioration of concanavalin A-induced autoimmune hepatitis by magnesium isoglycyrrhizinate through inhibition of CD4+CD25-CD69+ subset proliferation

Yang Q, Wang J, Liu R, Wang Z, Li Y, Zhang Y, Hao X, Huang Y, Xie W, Wei H

Drug Design, Development and Therapy 2016, 10:443-453

Published Date: 25 January 2016

In vitro stress effect on degradation and drug release behaviors of basic fibroblast growth factor – poly(lactic-co-glycolic-acid) microsphere

Xiong Y, Yu ZP, Lang Y, Hu JY, Li H, Yan YG, Tu CQ, Yang TF, Song YM, Duan H, Pei FX

Drug Design, Development and Therapy 2016, 10:431-440

Published Date: 25 January 2016

Formulation, optimization, and pharmacodynamic evaluation of chitosan/phospholipid/β-cyclodextrin microspheres

Shan L, Tao EX, Meng QH, Hou WX, Liu K, Shang HC, Tang JB, Zhang WF

Drug Design, Development and Therapy 2016, 10:417-429

Published Date: 25 January 2016

Depot injectable atorvastatin biodegradable in situ gel: development, optimization, in vitro, and in vivo evaluation

Ahmed TA, Alharby YA, El-Helw AM, Hosny KM, El-Say KM

Drug Design, Development and Therapy 2016, 10:405-415

Published Date: 20 January 2016

High-dose OxyContin to treat pain associated with bone metastasis in patients with small-cell lung cancer: a case study report

Zhou T, Zhang X, Dong Y, Zhuang FF, Jiang FQ, Yu JM, Zhang B

Drug Design, Development and Therapy 2016, 10:383-387

Published Date: 19 January 2016

Effects of probenecid and cimetidine on the pharmacokinetics of nemonoxacin in healthy Chinese volunteers

Zhang YF, Dai XJ, Yang Y, Chen XY, Wang T, Tang YB, Tsai CY, Chang LW, Chang YT, Zhong DF

Drug Design, Development and Therapy 2016, 10:357-370

Published Date: 20 January 2016

Clinical pharmacology study of cariprazine (MP-214) in patients with schizophrenia (12-week treatment)

Nakamura T, Kubota T, Iwakaji A, Imada M, Kapás M, Morio Y

Drug Design, Development and Therapy 2016, 10:327-338

Published Date: 14 January 2016

Evidence of the gastroprotective and anti-Helicobacter pylori activities of β-mangostin isolated from Cratoxylum arborescens (vahl) blume

Sidahmed HMA, Hashim NM, Mohan S, Abdelwahab SI, Taha MME, Dehghan F, Yahayu M, Ee GCL, Loke MF, Vadivelu J

Drug Design, Development and Therapy 2016, 10:297-313

Published Date: 13 January 2016

Liposomal flucytosine capped with gold nanoparticle formulations for improved ocular delivery

Salem HF, Ahmed SM, Omar MM

Drug Design, Development and Therapy 2016, 10:277-295

Published Date: 13 January 2016

Quetiapine monotherapy in acute treatment of generalized anxiety disorder: a systematic review and meta-analysis of randomized controlled trials

Maneeton N, Maneeton B, Woottiluk P, Likhitsathian S, Suttajit S, Boonyanaruthee V, Srisurapanont M

Drug Design, Development and Therapy 2016, 10:259-276

Published Date: 12 January 2016

A clinical prognostic scoring system for resectable gastric cancer to predict survival and benefit from paclitaxel- or oxaliplatin-based adjuvant chemotherapy

Qian J, Qian Y, Wang J, Gu B, Pei D, He S, Zhu F, Røe OD, Xu J, Liu L, Gu Y, Guo R, Yin Y, Shu Y, Chen X

Drug Design, Development and Therapy 2016, 10:241-258

Published Date: 24 February 2016

Pasireotide: a novel treatment for patients with acromegaly

Cuevas-Ramos D, Fleseriu M

Drug Design, Development and Therapy 2016, 10:227-239

Published Date: 11 January 2016

Spotlight on ixazomib: potential in the treatment of multiple myeloma

Muz B, Ghazarian RN, Ou M, Luderer MJ, Kusdono HD, Azab AK

Drug Design, Development and Therapy 2016, 10:217-226

Published Date: 11 January 2016

Preparation, characterization, and in vivo evaluation of intranasally administered liposomal formulation of donepezil

Al Asmari AK, Ullah Z, Tariq M, Fatani A

Drug Design, Development and Therapy 2016, 10:205-215

Published Date: 12 January 2016

Design and evaluation of novel interferon lambda analogs with enhanced antiviral activity and improved drug attributes

Yu D, Zhao M, Dong L, Zhao L, Zou M, Sun H, Zhang M, Liu H, Zou Z

Drug Design, Development and Therapy 2016, 10:163-182

Published Date: 6 January 2016

Isolation and evaluation of biological efficacy of quercetol in human hepatic carcinoma cells

Ali H, Dixit S, Ali D, Alkahtane AA, Alarifi S, Ali BA, Alkahtani S

Drug Design, Development and Therapy 2016, 10:155-162

Published Date: 6 January 2016

Self-emulsifying drug delivery systems as a tool to improve solubility and bioavailability of resveratrol

Balata GF, Essa EA, Shamardl HA, Zaidan SH, Abourehab MAS

Drug Design, Development and Therapy 2016, 10:117-128

Published Date: 5 January 2016

The gastroprotective effects of hydroalcoholic extract of Monolluma quadrangula against ethanol-induced gastric mucosal injuries in Sprague Dawley rats

Ibrahim IAA, Abdulla MA, Hajrezaie M, Bader A, Shahzad N, Al-Ghamdi SS, Gushash AS, Hasanpourghadi M

Drug Design, Development and Therapy 2016, 10:93-105

Published Date: 30 December 2015

Promoting effect of small molecules in cardiomyogenic and neurogenic differentiation of rat bone marrow-derived mesenchymal stem cells

Khanabdali R, Saadat A, Fazilah M, Bazli KFK, Qazi RM, Khalid RS, Hasan Adli DS, Moghadamtousi SZ, Naeem N, Khan I, Salim A, Shamsuddin SAA, Mohan G

Drug Design, Development and Therapy 2016, 10:81-91

Published Date: 24 December 2015

MicroRNA-125a-5p modulates human cervical carcinoma proliferation and migration by targeting ABL2

Qin X, Wan Y, Wang S, Xue M

Drug Design, Development and Therapy 2016, 10:71-79

Published Date: 24 December 2015

BCc1, the novel antineoplastic nanocomplex, showed potent anticancer effects in vitro and in vivo

Kalanaky S, Hafizi M, Fakharzadeh S, Vasei M, Langroudi L, Janzamin E, Hashemi SM, Khayamzadeh M, Soleimani M, Akbari ME, Nazaran MH

Drug Design, Development and Therapy 2016, 10:59-70

Published Date: 30 December 2015

MEK inhibitors and their potential in the treatment of advanced melanoma: the advantages of combination therapy

Tran KA, Cheng MY, Mitra A, Ogawa H, Shi VY, Olney LP, Kloxin AM, Maverakis E

Drug Design, Development and Therapy 2016, 10:43-52

Published Date: 21 December 2015

Modulation of neurotrophic signaling pathways by polyphenols

Moosavi F, Hosseini R, Saso L, Firuzi O

Drug Design, Development and Therapy 2016, 10:23-42

Published Date: 21 December 2015

Plasmid pORF-hTRAIL targeting to glioma using transferrin-modified polyamidoamine dendrimer

Gao S, Li J, Jiang C, Hong B, Hao B

Drug Design, Development and Therapy 2016, 10:1-11

Published Date: 17 December 2015

Association of systolic blood pressure drop with intravenous administration of itraconazole in children with hemato-oncologic disease

Lee HJ, Lee B, Park JD, Jeong HJ, Choi YH, Ju HY, Hong CR, Lee JW, Kim H, Suh DI, Park KD, Kang HJ, Shin HY, Ahn HS

Drug Design, Development and Therapy 2015, 9:6489-6495

Published Date: 17 December 2015

Effect of caffeic acid phenethyl ester on bone formation in the expanded inter-premaxillary suture

Kazancioglu HO, Aksakalli S, Ezirganli S, Birlik M, Esrefoglu M, Acar AH

Drug Design, Development and Therapy 2015, 9:6483-6488

Published Date: 21 December 2015

Effects of vitamin C treatment on collar-induced intimal thickening

Arun MZ, Üstünes L, Sevin G, Özer E

Drug Design, Development and Therapy 2015, 9:6461-6473

Published Date: 15 December 2015

Enhanced antitumoral activity of doxorubicin against lung cancer cells using biodegradable poly(butylcyanoacrylate) nanoparticles

Melguizo C, Cabeza L, Prados J, Ortiz R, Caba O, Rama AR, Delgado ÁV, Arias JL

Drug Design, Development and Therapy 2015, 9:6433-6444

Published Date: 14 December 2015

Autophagy facilitates lung adenocarcinoma resistance to cisplatin treatment by activation of AMPK/mTOR signaling pathway

Wu T, Wang MC, Jing L, Liu ZY, Guo H, Liu Y, Bai YY, Cheng YZ, Nan KJ, Liang X

Drug Design, Development and Therapy 2015, 9:6421-6431

Published Date: 14 December 2015

Idiopathic pulmonary fibrosis: current treatment options and critical appraisal of nintedanib

Bonella F, Stowasser S, Wollin L

Drug Design, Development and Therapy 2015, 9:6407-6419

Published Date: 14 December 2015

Phase II trial of docetaxel combined with nedaplatin for patients with recurrent and metastatic nasopharyngeal carcinoma

Peng PJ, Lv BJ, Tang C, Liao H, Lin Z, Liu YM, Wang ZH, Wang SY, Cheng ZB

Drug Design, Development and Therapy 2015, 9:6401-6405

Published Date: 10 December 2015

Identification of covalent active site inhibitors of dengue virus protease

Koh-Stenta X, Joy J, Wang SF, Kwek PZ, Wee JLK, Wan KF, Gayen S, Chen AS, Kang C, Lee MA, Poulsen A, Vasudevan SG, Hill J, Nacro K

Drug Design, Development and Therapy 2015, 9:6389-6399

Published Date: 10 December 2015

Effect of oral N-acetylcysteine on COPD patients with microsatellite polymorphism in the heme oxygenase-1 gene promoter

Zhang JQ, Zhang JQ, Fang LZ, Liu L, Fu WP, Dai LM

Drug Design, Development and Therapy 2015, 9:6379-6387

Published Date: 7 December 2015

Effects of intravitreal injection of netrin-1 in retinal neovascularization of streptozotocin-induced diabetic rats

Yu Y, Zou J, Han Y, Quyang L, He H, Hu P, Shao Y, Tu P

Drug Design, Development and Therapy 2015, 9:6363-6377

Published Date: 7 December 2015

Tanshinone IIA ameliorates dextran sulfate sodium-induced inflammatory bowel disease via the pregnane X receptor

Zhang X, Wang Y, Ma Z, Liang Q, Tang X, Hu D, Tan H, Xiao C, Gao Y

Drug Design, Development and Therapy 2015, 9:6343-6362

Published Date: 7 December 2015

Hypoglycemic effect and mechanism of honokiol on type 2 diabetic mice

Sun J, Fu X, Liu Y, Wang Y, Huo B, Guo Y, Gao X, Li W, Hu X

Drug Design, Development and Therapy 2015, 9:6327-6342

Published Date: 4 December 2015

Green tea extract as a treatment for patients with wild-type transthyretin amyloidosis: an observational study

aus dem Siepen F, Bauer R, Aurich M, Buss SJ, Steen H, Altland K, Katus HA, Kristen AV

Drug Design, Development and Therapy 2015, 9:6319-6325

Published Date: 4 December 2015

Ginkgo biloba extract mitigates liver fibrosis and apoptosis by regulating p38 MAPK, NF-κB/IκBα, and Bcl-2/Bax signaling

Wang YY, Wang R, Wang YJ, Peng RQ, Wu Y, Yuan YF

Drug Design, Development and Therapy 2015, 9:6303-6317

Published Date: 3 December 2015

Synthetic biology for pharmaceutical drug discovery

Trosset JY, Carbonell P

Drug Design, Development and Therapy 2015, 9:6285-6302

Published Date: 3 December 2015

Sulodexide therapy for the treatment of diabetic nephropathy, a meta-analysis and literature review

Li R, Xing J, Mu XJ, Wang H, Zhang L, Zhao Y, Zhang Y

Drug Design, Development and Therapy 2015, 9:6275-6283

Published Date: 3 December 2015

Enzymatic vitreolysis with recombinant tissue plasminogen activator for vitreomacular traction

Raczyńska D, Lipowski P, Zorena K, Skorek A, Glasner P

Drug Design, Development and Therapy 2015, 9:6259-6268

Published Date: 27 November 2015

Timosaponin B-II ameliorates diabetic nephropathy via TXNI P, mTOR, and NF-κB signaling pathways in alloxan-induced mice

Yuan YL, Guo CR, Cui LL, Ruan SX, Zhang CF, Ji D, Yang ZL, Li F

Drug Design, Development and Therapy 2015, 9:6247-6258

Published Date: 27 November 2015

Hyaluronic acid abrogates ethanol-dependent inhibition of collagen biosynthesis in cultured human fibroblasts

Donejko M, Przylipiak A, Rysiak E, Miltyk W, Galicka E, Przylipiak J, Zaręba I, Surazynski A

Drug Design, Development and Therapy 2015, 9:6225-6233

Published Date: 24 November 2015

Different effects of statins on induction of diabetes mellitus: an experimental study

Zhao W, Zhao SP

Drug Design, Development and Therapy 2015, 9:6211-6223

Published Date: 24 November 2015

Radiotherapy potentiation with weekly cisplatin compared to standard every 3 weeks cisplatin chemotherapy for locoregionally advanced head and neck squamous cell carcinoma 

Fayette J, Molin Y, Lavergne E, Montbarbon X, Racadot S, Poupart M, Ramade A, Zrounba P, Ceruse P, Pommier P

Drug Design, Development and Therapy 2015, 9:6203-6210

Published Date: 26 November 2015

Synthesis, structural characterization, and anticancer activity of a monobenzyltin compound against MCF-7 breast cancer cells

Fani S, Kamalidehghan B, Lo KM, Hashim NM, Chow KM, Ahmadipour F

Drug Design, Development and Therapy 2015, 9:6191-6201

Published Date: 23 November 2015

Spotlight on tavaborole for the treatment of onychomycosis

Jinna S, Finch J

Drug Design, Development and Therapy 2015, 9:6185-6190

Published Date: 20 November 2015

Prospective study on nanoparticle albumin-bound paclitaxel in advanced breast cancer: clinical results and biological observations in taxane-pretreated patients

Fabi A, Giannarelli D, Malaguti P, Ferretti G, Vari S, Papaldo P, Nisticò C, Caterino M, De Vita R, Mottolese M, Iacorossi L, Cognetti F

Drug Design, Development and Therapy 2015, 9:6177-6183

Published Date: 20 November 2015

Influence of glucosamine on the bioactivity of insulin delivered subcutaneously and in an oral nanodelivery system

Al-Kurdi ZI, Chowdhry BZ, Leharne SA, Qinna NA, Al Omari MMH, Badwan AA

Drug Design, Development and Therapy 2015, 9:6167-6176

Published Date: 19 November 2015

Efficacy and safety of a conversion from the original tacrolimus and mycophenolate mofetil to the generics Tacpan® and Mowel® after liver transplantation

Vollmar J, Bellmann MC, Darstein F, Hoppe-Lotichius M, Mittler J, Heise M, Rüttger B, Weyer V, Zimmermann A, Lang H, Galle PR, Zimmermann T

Drug Design, Development and Therapy 2015, 9:6139-6149

Published Date: 17 November 2015

DNAzyme-based probe for circulating microRNA detection in peripheral blood

Shao G, Ji S, Wu A, Liu C, Wang M, Zhang P, Jiao Q, Kang Y

Drug Design, Development and Therapy 2015, 9:6109-6117

Published Date: 16 November 2015

Protective effects of triptolide on retinal ganglion cells in a rat model of chronic glaucoma

Yang F, Wang DM, Wu LL, Li Y

Drug Design, Development and Therapy 2015, 9:6095-6107

Published Date: 16 November 2015

Apatinib for molecular targeted therapy in tumor

Zhang H

Drug Design, Development and Therapy 2015, 9:6075-6081

Published Date: 13 November 2015

A single-arm Phase II validation study of preventing oxaliplatin-induced hypersensitivity reactions by dexamethasone: the AVOID trial

Yoshida Y, Hirata K, Matsuoka H, Iwamoto S, Kotaka M, Fujita H, Aisu N, Hoshino S, Kosaka T, Maeda K, Kiyomi F, Yamashita Y

Drug Design, Development and Therapy 2015, 9:6067-6073

Published Date: 12 November 2015

Attenuation of myocardial fibrosis with curcumin is mediated by modulating expression of angiotensin II AT1/AT2 receptors and ACE2 in rats

Pang XF, Zhang LH, Bai F, Wang NP, Garner RE, McKallip RJ, Zhao ZQ

Drug Design, Development and Therapy 2015, 9:6043-6054

Published Date: 11 November 2015

Profile of suvorexant in the management of insomnia

Sutton EL

Drug Design, Development and Therapy 2015, 9:6035-6042

Published Date: 11 November 2015

6-Gingerol alleviates exaggerated vasoconstriction in diabetic rat aorta through direct vasodilation and nitric oxide generation

Ghareib SA, El-Bassossy HM, Elberry AA, Azhar A, Watson ML, Banjar ZM

Drug Design, Development and Therapy 2015, 9:6019-6026

Published Date: 9 November 2015

Glucose abnormalities in Asian patients with chronic hepatitis C

Bo Q, Orsenigo R, Wang J, Griffel L, Brass C

Drug Design, Development and Therapy 2015, 9:6009-6017

Published Date: 9 November 2015

Progesterone regulates the proliferation of breast cancer cells – in vitro evidence

Azeez JM, Sithul H, Hariharan I, Sreekumar S, Prabhakar J, Sreeja S, Pillai MR

Drug Design, Development and Therapy 2015, 9:5987-5999

Published Date: 9 November 2015

Phytocompounds and modulatory effects of Anacardium microcarpum (cajui) on antibiotic drugs used in clinical infections

Barbosa-Filho VM, Waczuk EP, Leite NF, Menezes IRA, da Costa JGM, Lacerda SR, Adedara IA, Coutinho HDM, Posser T, Kamdem JP

Drug Design, Development and Therapy 2015, 9:5965-5972

Published Date: 6 November 2015

Lentinus squarrosulus (Mont.) mycelium enhanced antioxidant status in rat model

Mhd Omar NA, Abdullah S, Abdullah N, Kuppusamy UR, Abdulla MA, Sabaratnam V

Drug Design, Development and Therapy 2015, 9:5957-5964

Published Date: 6 November 2015

Tumor-induced VEGF-C overexpression in retroperitoneal lymph nodes in VX2 carcinoma-bearing rabbits

Huang YW, Zhou Y, Lan CY, Wang Y, Feng YL, Luo RZ, Liu JH

Drug Design, Development and Therapy 2015, 9:5949-5956

Published Date: 5 November 2015

Efficacy and safety of ifosfamide-based chemotherapy for osteosarcoma: a meta-analysis

Fan XL, Cai GP, Zhu LL, Ding GM

Drug Design, Development and Therapy 2015, 9:5925-5932

Published Date: 4 November 2015

PACE4 regulates apoptosis in human prostate cancer cells via endoplasmic reticulum stress and mitochondrial signaling pathways

Yao Z, Sun B, Hong Q, Yan J, Mu D, Li J, Sheng H, Guo H

Drug Design, Development and Therapy 2015, 9:5911-5923

Published Date: 5 November 2015

Critical appraisal of Timothy grass pollen extract GRAZAX® in the management of allergic rhinitis

Scaparrotta A, Attanasi M, Petrosino MI, Di Filippo P, Di Pillo S, Chiarelli F

Drug Design, Development and Therapy 2015, 9:5897-5909

Published Date: 3 November 2015

In silico approach for the discovery of new PPARγ modulators among plant-derived polyphenols

Encinar JA, Fernández-Ballester G, Galiano-Ibarra V, Micol V

Drug Design, Development and Therapy 2015, 9:5877-5895

Published Date: 4 November 2015

Efficacy and tolerability of oral oxycodone and oxycodone/naloxone combination in opioid-naïve cancer patients: a propensity analysis

Lazzari M, Greco MT, Marcassa C, Finocchi S, Caldarulo C, Corli O

Drug Design, Development and Therapy 2015, 9:5863-5872

Published Date: 2 November 2015

Arsenic sulfide combined with JQ1, chemotherapy agents, or celecoxib inhibit gastric and colon cancer cell growth

Zhang L, Tong Y, Zhang X, Pan M, Chen S

Drug Design, Development and Therapy 2015, 9:5851-5862

Published Date: 30 October 2015

The relevance of piroxicam for the prevention and treatment of nonmelanoma skin cancer and its precursors

Campione E, Paternò EJ, Candi E, Falconi M, Costanza G, Diluvio L, Terrinoni A, Bianchi L, Orlandi A

Drug Design, Development and Therapy 2015, 9:5843-5850

Published Date: 29 October 2015

Prevalence of the rs7903146C>T polymorphism in TCF7L2 gene for prediction of type 2 diabetes risk among Iranians of different ethnicities

Allahdini M, Kamalidehghan B, Akbari L, Azadfar P, Rahmani A, Ahmadipour F, Meng GY, Masserrat A, Houshmand M

Drug Design, Development and Therapy 2015, 9:5835-5841

Published Date: 28 October 2015

Development of oral dispersible tablets containing prednisolone nanoparticles for the management of pediatric asthma

Chen YD, Liang ZY, Cen YY, Zhang H, Han MG, Tian YQ, Zhang J, Li SJ, Yang DS

Drug Design, Development and Therapy 2015, 9:5815-5825

Published Date: 20 November 2015

Curcuma purpurascens BI. rhizome accelerates rat excisional wound healing: involvement of Hsp70/Bax proteins, antioxidant defense, and angiogenesis activity

Rouhollahi E, Moghadamtousi SZ, Hajiaghaalipour F, Zahedifard M, Tayeby F, Awang K, Abdulla MA, Mohamed Z

Drug Design, Development and Therapy 2015, 9:5805-5813

Published Date: 27 October 2015

Empagliflozin in the treatment of type 2 diabetes: evidence to date

Shubrook JH, Baradar Bokaie B, Adkins SE

Drug Design, Development and Therapy 2015, 9:5793-5803

Published Date: 30 October 2015

Efficacy of trabectedin in advanced soft tissue sarcoma: beyond lipo- and leiomyosarcoma

De Sanctis R, Marrari A, Marchetti S, Mussi C, Balzarini L, Lutman FR, Daolio P, Bastoni S, Bertuzzi AF, Quagliuolo V, Santoro A

Drug Design, Development and Therapy 2015, 9:5785-5791

Published Date: 27 October 2015

Reductive metabolism of oxymatrine is catalyzed by microsomal CYP3A4

Liu W, Shi J, Zhu L, Dong L, Luo F, Zhao M, Wang Y, Hu M, Lu L, Liu Z

Drug Design, Development and Therapy 2015, 9:5771-5783

Published Date: 30 October 2015

Rationale and clinical utility of the darunavir–cobicistat combination in the treatment of HIV/AIDS

Putcharoen O, Do T, Avihingsanon A, Ruxrungtham K

Drug Design, Development and Therapy 2015, 9:5763-5769

Published Date: 23 October 2015

Efficacy of thrombomodulin for acute exacerbation of idiopathic pulmonary fibrosis and nonspecific interstitial pneumonia: a nonrandomized prospective study

Abe M, Tsushima K, Matsumura T, Ishiwata T, Ichimura Y, Ikari J, Terada J, Tada Y, Sakao S, Tanabe N, Tatsumi K

Drug Design, Development and Therapy 2015, 9:5755-5762

Published Date: 23 October 2015

Antibacterial activity and therapeutic efficacy of Fl-PRPRPL-5, a cationic amphiphilic polyproline helix, in a mouse model of staphylococcal skin infection

Thangamani S, Nepal M, Chmielewski J, Seleem MN

Drug Design, Development and Therapy 2015, 9:5749-5754

Published Date: 22 October 2015

Mechanism and pharmacological rescue of berberine-induced hERG channel deficiency

Yan M, Zhang KP, Shi YH, Feng LF, Lv L, Li BX

Drug Design, Development and Therapy 2015, 9:5737-5747

Published Date: 22 October 2015

4-Hydroxyisoleucine ameliorates an insulin resistant-like state in 3T3-L1 adipocytes by regulating TACE/TIMP3 expression

Gao F, Du W, Zafar MI, Shafqat RA, Jian L, Cai Q, Lu FR

Drug Design, Development and Therapy 2015, 9:5727-5736

Published Date: 20 October 2015

Brivaracetam: review of its pharmacology and potential use as adjunctive therapy in patients with partial onset seizures

Mumoli L, Palleria C, Gasparini S, Citraro R, Labate A, Ferlazzo E, Gambardella A, De Sarro G, Russo E

Drug Design, Development and Therapy 2015, 9:5719-5725

Published Date: 19 October 2015

Evaluation of the cardiovascular effects of varenicline in rats

Selçuk EB, Sungu M, Parlakpinar H, Ermiş N, Taslıdere E, Vardı N, Yalçınsoy M, Sagır M, Polat A, Karatas M, Kayhan-Tetik B

Drug Design, Development and Therapy 2015, 9:5705-5717

Published Date: 22 October 2015

Safety and pharmacokinetics of dicloxacillin in healthy Chinese volunteers following single and multiple oral doses

Wu GL, Zheng YL, Zhou HL, Hu XJ, Liu J, Zhai Y, Zhu MX, Wu LH, Shentu JZ

Drug Design, Development and Therapy 2015, 9:5687-5695

Published Date: 16 October 2015

Bifunctional fused polypeptide inhibits the growth and metastasis of breast cancer

Liang AL, Qian HL, Zhang TT, Zhou N, Wang HJ, Men XT, Qi W, Zhang PP, Fu M, Liang X, Lin C, Liu YJ

Drug Design, Development and Therapy 2015, 9:5671-5686

Published Date: 16 October 2015

Adenoviral delivery of truncated MMP-8 fused with the hepatocyte growth factor mutant 1K1 ameliorates liver cirrhosis and promotes hepatocyte proliferation

Liu JH, Li JB, Fu WW, Tang JC, Feng X, Chen J, Liang YL, Jin RA, Xie AY, Cai XJ

Drug Design, Development and Therapy 2015, 9:5655-5667

Published Date: 16 October 2015

Development of PPAR-agonist GW0742 as antidiabetic drug: study in animals

Niu HS, Ku PM, Niu CS, Cheng JT, Lee KS

Drug Design, Development and Therapy 2015, 9:5625-5632

Published Date: 14 October 2015

Paeoniflorin inhibits human glioma cells via STAT3 degradation by the ubiquitin–proteasome pathway

Nie XH, Ou-yang J, Xing Y, Li DY, Dong XY, Liu RE, Xu RX

Drug Design, Development and Therapy 2015, 9:5611-5622

Published Date: 13 October 2015

Urinary kallidinogenase for the treatment of cerebral arterial stenosis

Zhao L, Zhao Y, Wan Q, Zhang H

Drug Design, Development and Therapy 2015, 9:5595-5600

Published Date: 13 October 2015

Acquired latent tuberculosis infection in psoriasis patients treated with etanercept in the People’s Republic of China

Li CR, Mao QX, Chen M, Jia WX, Yao X, Feng SY, Jia H, Gong JQ, Yang XY

Drug Design, Development and Therapy 2015, 9:5591-5594

Published Date: 12 October 2015

Arsenic sulfide inhibits cell migration and invasion of gastric cancer in vitro and in vivo

Zhang L, Kim S, Ding W, Tong Y, Zhang X, Pan M, Chen S

Drug Design, Development and Therapy 2015, 9:5579-5590

Published Date: 9 October 2015

Novel dehydroepiandrosterone troche supplementation improves the serum androgen profile of women undergoing in vitro fertilization

Keane KN, Hinchliffe PM, Namdar N, Conceicao JL, Newsholme P, Yovich JL

Drug Design, Development and Therapy 2015, 9:5569-5578

Published Date: 9 October 2015

Design, synthesis, and antitumor evaluation of histone deacetylase inhibitors with L-phenylglycine scaffold

Zhang Y, Li X, Hou J, Huang Y, Xu W

Drug Design, Development and Therapy 2015, 9:5553-5567

Published Date: 8 October 2015

Plumbagin suppresses epithelial to mesenchymal transition and stemness via inhibiting Nrf2-mediated signaling pathway in human tongue squamous cell carcinoma cells

Pan ST, Qin Y, Zhou ZW, He ZX, Zhang X, Yang T, Yang YX, Wang D, Zhou SF, Qiu JX

Drug Design, Development and Therapy 2015, 9:5511-5551

Published Date: 5 October 2015

Neuroprotective potential of ferulic acid in the rotenone model of Parkinson’s disease

Ojha S, Javed H, Azimullah S, Abul Khair SB, Haque ME

Drug Design, Development and Therapy 2015, 9:5499-5510

Published Date: 7 October 2015

3-Coumaranone derivatives as inhibitors of monoamine oxidase

Van Dyk AS, Petzer JP, Petzer A, Legoabe LJ

Drug Design, Development and Therapy 2015, 9:5479-5489

Published Date: 3 October 2015

A novel small-molecule inhibitor of HIV-1 entry

Heredia A, Latinovic OS, Barbault F, de Leeuw EPH

Drug Design, Development and Therapy 2015, 9:5469-5478

Published Date: 1 October 2015

Maraviroc: a review of its use in HIV infection and beyond

Woollard SM, Kanmogne GD

Drug Design, Development and Therapy 2015, 9:5447-5468

Published Date: 1 October 2015

A proposal for an individualized pharmacogenetic-guided isoniazid dosage regimen for patients with tuberculosis

Jung JA, Kim TE, Lee H, Jeong BH, Park HY, Jeon K, Kwon OJ, Ko JW, Choi R, Woo HI, Koh WJ, Lee SY

Drug Design, Development and Therapy 2015, 9:5433-5438

Published Date: 30 September 2015

Systematic review and meta-analysis: bezafibrate in patients with primary biliary cirrhosis

Yin Q, Li J, Xia Y, Zhang R, Wang J, Lu W, Zhou Y, Zheng Y, Abudumijiti H, Chen R, Chen K, Li S, Liu T, Wang F, Lu J, Zhou Y, Guo C

Drug Design, Development and Therapy 2015, 9:5407-5419

Published Date: 30 September 2015

Intravitreal anti-VEGF injections for treating wet age-related macular degeneration: a systematic review and meta-analysis

Ba J, Peng RS, Xu D, Li YH, Shi H, Wang QY, Yu J

Drug Design, Development and Therapy 2015, 9:5397-5405

Published Date: 28 September 2015

Ghrelin reduces liver impairment in a model of concanavalin A-induced acute hepatitis in mice

Mao YQ, Wang JB, Yu FJ, Cheng J, Li HQ, Guo CY, Fan XM

Drug Design, Development and Therapy 2015, 9:5385-5396

Published Date: 28 September 2015

Collagenase IV plays an important role in regulating hair cycle by inducing VEGF, IGF-1, and TGF-β expression

Hou C, Miao Y, Wang J, Wang X, Chen CY, Hu ZQ

Drug Design, Development and Therapy 2015, 9:5373-5383

Published Date: 25 September 2015

Efficacy and safety of a vaginal medicinal product containing three strains of probiotic bacteria: a multicenter, randomized, double-blind, and placebo-controlled trial

Tomusiak A, Strus M, Heczko PB, Adamski P, Stefański G, Mikołajczyk-Cichońska A, Suda-Szczurek M

Drug Design, Development and Therapy 2015, 9:5345-5354

Published Date: 25 September 2015

Effect of curcumin on aging retinal pigment epithelial cells

Zhu W, Wu Y, Meng YF, Wang JY, Xu M, Tao JJ, Lu J

Drug Design, Development and Therapy 2015, 9:5337-5344

Published Date: 25 September 2015

Investigation of the bioequivalence of montelukast chewable tablets after a single oral administration using a validated LC-MS/MS method

Zaid AN, Abualhasan MN, Watson DG, Mousa A, Ghazal N, Bustami R

Drug Design, Development and Therapy 2015, 9:5315-5321

Published Date: 23 September 2015

Chamaejasmin B exerts anti-MDR effect in vitro and in vivo via initiating mitochondria-dependant intrinsic apoptosis pathway

Wang YJ, Li Q, Xiao HB, Li YJ, Yang Q, Kan XX, Chen Y, Liu XN, Weng XG, Chen X, Cai WY, Guo Y, Huang HF, Zhu XX

Drug Design, Development and Therapy 2015, 9:5301-5313

Published Date: 22 September 2015

The rapid effects of budesonide plus formoterol in patients with obstructive airway diseases

Bayiz H, Ozkaya S, Dirican A, Ece F

Drug Design, Development and Therapy 2015, 9:5287-5290

Published Date: 21 September 2015

Improvement of oral bioavailability of lovastatin by using nanostructured lipid carriers

Zhou J, Zhou DX

Drug Design, Development and Therapy 2015, 9:5269-5275

Published Date: 18 September 2015

Exposure–outcome analysis in depressed patients treated with paroxetine using population pharmacokinetics

Kim JR, Woo HI, Chun MR, Lim SW, Kim HD, Na HS, Chung MW, Myung W, Lee SY, Kim DK

Drug Design, Development and Therapy 2015, 9:5247-5254

Published Date: 16 September 2015

Companion diagnostics and molecular imaging-enhanced approaches for oncology clinical trials

Van Heertum RL, Scarimbolo R, Ford R, Berdougo E, O’Neal M

Drug Design, Development and Therapy 2015, 9:5215-5223

Published Date: 11 September 2015

Dabigatran etexilate retards the initiation and progression of atherosclerotic lesions and inhibits the expression of oncostatin M in apolipoprotein E-deficient mice

Preusch MR, Ieronimakis N, Wijelath ES, Cabbage S, Ricks J, Bea F, Reyes M, van Ryn J, Rosenfeld ME

Drug Design, Development and Therapy 2015, 9:5203-5211

Published Date: 10 September 2015

Pentoxifylline and electromagnetic field improved bone fracture healing in rats

Atalay Y, Gunes N, Guner MD, Akpolat V, Celik MS, Guner R

Drug Design, Development and Therapy 2015, 9:5195-5201

Published Date: 9 September 2015

Exposure–response model for sibutramine and placebo: suggestion for application to long-term weight-control drug development

Han S, Jeon S, Hong T, Lee J, Bae SH, Park WS, Park G, Youn S, Jang DY, Kim KS, Yim DS

Drug Design, Development and Therapy 2015, 9:5185-5194

Published Date: 9 September 2015

Regulation of bone formation by baicalein via the mTORC1 pathway

Li SF, Tang JJ, Chen J, Zhang P, Wang T, Chen TY, Yan B, Huang B, Wang L, Huang MJ, Zhang ZM, Jin DD

Drug Design, Development and Therapy 2015, 9:5169-5183

Published Date: 9 September 2015

The IL-17A G-197A and IL-17F 7488T/C polymorphisms are associated with increased risk of cancer in Asians: a meta-analysis

Wang H, Zhang Y, Liu Z, Zhang Y, Zhao H, Du S

Drug Design, Development and Therapy 2015, 9:5159-5168

Published Date: 24 September 2015

Icariside II ameliorates diabetic nephropathy in streptozotocin-induced diabetic rats

Tian W, Lei H, Guan R, Xu Y, Li H, Wang L, Yang B, Gao Z, Xin Z

Drug Design, Development and Therapy 2015, 9:5147-5157

Published Date: 7 September 2015

Novel synthesizing method of pH-dependent doxorubicin-loaded anti-CD22-labelled drug delivery nanosystem

Sun M, Wang J, Lu Q, Xia G, Zhang Y, Song L, Fang Y

Drug Design, Development and Therapy 2015, 9:5123-5133

Published Date: 7 September 2015

Anthocyanins inhibit high-glucose-induced cholesterol accumulation and inflammation by activating LXRα pathway in HK-2 cells

Du C, Shi Y, Ren Y, Wu H, Yao F, Wei J, Wu M, Hou Y, Duan H

Drug Design, Development and Therapy 2015, 9:5099-5113

Published Date: 4 September 2015

Distinct prognostic values and potential drug targets of ALDH1 isoenzymes in non-small-cell lung cancer

You Q, Guo H, Xu D

Drug Design, Development and Therapy 2015, 9:5087-5097

Published Date: 3 September 2015

Phase III study of pasireotide long-acting release in patients with metastatic neuroendocrine tumors and carcinoid symptoms refractory to available somatostatin analogues

Wolin EM, Jarzab B, Eriksson B, Walter T, Toumpanakis C, Morse MA, Tomassetti P, Weber MM, Fogelman DR, Ramage J, Poon D, Gadbaw B, Li J, Pasieka JL, Mahamat A, Swahn F, Newell-Price J, Mansoor W, Öberg K

Drug Design, Development and Therapy 2015, 9:5075-5086

Published Date: 3 September 2015

Paeonia lactiflora Pall. protects against ANIT-induced cholestasis by activating Nrf2 via PI3K/Akt signaling pathway

Ma X, Zhao Y, Zhu Y, Chen Z, Wang J, Li R, Chen C, Wei S, Li J, Liu B, Wang R, Li Y, Wang L, Xiao X

Drug Design, Development and Therapy 2015, 9:5061-5074

Published Date: 2 September 2015

Inhibition of HIV-1 by curcumin A, a novel curcumin analog

Kumari N, Kulkarni AA, Lin X, McLean C, Ammosova T, Ivanov A, Hipolito M, Nekhai S, Nwulia E

Drug Design, Development and Therapy 2015, 9:5051-5060

Published Date: 3 September 2015

Pharmacokinetics, pharmacodynamics, and tolerability of LC350189, a novel xanthine oxidase inhibitor, in healthy subjects

Yoon S, Shin D, Lee H, Jang IJ, Yu KS

Drug Design, Development and Therapy 2015, 9:5033-5049

Published Date: 31 August 2015

Bu-Shen-Ning-Xin Decoction ameliorated the osteoporotic phenotype of ovariectomized mice without affecting the serum estrogen concentration or uterus

Wang L, Qiu XM, Gui YY, Xu YP, Gober HJ, Li DJ

Drug Design, Development and Therapy 2015, 9:5019-5031

Published Date: 31 August 2015

Pharmacokinetic and nephroprotective benefits of using Schisandra chinensis extracts in a cyclosporine A-based immune-suppressive regime

Lai Q, Wei JB, Mahmoodurrahman M, Zhang CX, Quan SJ, Li TM, Yu Y

Drug Design, Development and Therapy 2015, 9:4997-5018

Published Date: 28 August 2015

A current review of folate receptor alpha as a potential tumor target in non-small-cell lung cancer

Shi H, Guo J, Li C, Wang Z

Drug Design, Development and Therapy 2015, 9:4989-4996

Published Date: 31 August 2015

Lipopolysaccharide-induced caveolin-1 phosphorylation-dependent increase in transcellular permeability precedes the increase in paracellular permeability

Wang N, Zhang D, Sun G, Zhang H, You Q, Shao M, Yue Y

Drug Design, Development and Therapy 2015, 9:4965-4977

Published Date: 28 August 2015

CXCR4 in breast cancer: oncogenic role and therapeutic targeting

Xu C, Zhao H, Chen H, Yao Q

Drug Design, Development and Therapy 2015, 9:4953-4964

Published Date: 28 August 2015

Insight into the mechanism of polyphenols on the activity of HMGR by molecular docking

Islam B, Sharma C, Adem A, Aburawi EH, Ojha S

Drug Design, Development and Therapy 2015, 9:4943-4951

Published Date: 28 August 2015

The effect of curcumin and its nanoformulation on adjuvant-induced arthritis in rats

Zheng ZL, Sun YH, Liu ZL, Zhang MQ, Li CQ, Cai H

Drug Design, Development and Therapy 2015, 9:4931-4942

Published Date: 27 August 2015

Immunosuppressive effects of the standardized extract of Phyllanthus amarus on cellular immune responses in Wistar-Kyoto rats

Ilangkovan M, Jantan I, Mesaik MA, Bukhari SNA

Drug Design, Development and Therapy 2015, 9:4917-4930

Published Date: 26 August 2015

Profile of omalizumab in the treatment of chronic spontaneous urticaria

Labrador-Horrillo M, Ferrer M

Drug Design, Development and Therapy 2015, 9:4909-4915

Published Date: 25 August 2015

Met tyrosine kinase inhibitor, PF-2341066, suppresses growth and invasion of nasopharyngeal carcinoma

Zhao Y, Zhang J, Tian Y, Xue C, Hu Z, Zhang L

Drug Design, Development and Therapy 2015, 9:4897-4907

Published Date: 26 August 2015

High-throughput sequencing of 16S rDNA amplicons characterizes bacterial composition in bronchoalveolar lavage fluid in patients with ventilator-associated pneumonia

Yang XJ, Wang YB, Zhou ZW, Wang GW, Wang XH, Liu QF, Zhou SF, Wang ZH

Drug Design, Development and Therapy 2015, 9:4883-4896

Published Date: 24 August 2015

Hydrogen sulfide-releasing naproxen suppresses colon cancer cell growth and inhibits NF-κB signaling

Kodela R, Nath N, Chattopadhyay M, Nesbitt DE, Velázquez-Martínez CA, Kashfi K

Drug Design, Development and Therapy 2015, 9:4873-4882

Published Date: 24 August 2015

Blood pyrrole-protein adducts as a diagnostic and prognostic index in pyrrolizidine alkaloid-hepatic sinusoidal obstruction syndrome

Gao H, Ruan JQ, Chen J, Li N, Ke CQ, Ye Y, Lin G, Wang JY

Drug Design, Development and Therapy 2015, 9:4861-4868

Published Date: 25 August 2015

Effects of histamine and its antagonists on murine T-cells and bone marrow-derived dendritic cells

Hu XF, Zafar MI, Gao F

Drug Design, Development and Therapy 2015, 9:4847-4860

Published Date: 21 August 2015

Nonalcoholic steatohepatitis: emerging targeted therapies to optimize treatment options

Milic S, Mikolasevic I, Krznaric-Zrnic I, Stanic M, Poropat G, Stimac D, Vlahovic-Palcevski V, Orlic L

Drug Design, Development and Therapy 2015, 9:4835-4845

Published Date: 20 August 2015

How we make cell therapy in Italy

Montemurro T, Viganò M, Budelli S, Montelatici E, Lavazza C, Marino L, Parazzi V, Lazzari L, Giordano R

Drug Design, Development and Therapy 2015, 9:4825-4834

Published Date: 20 August 2015

Translational challenges of animal models in Chagas disease drug development: a review

Chatelain E, Konar N

Drug Design, Development and Therapy 2015, 9:4807-4823

Published Date: 19 August 2015

Role of short-acting nitroglycerin in the management of ischemic heart disease

Boden WE, Padala SK, Cabral KP, Buschmann IR, Sidhu MS

Drug Design, Development and Therapy 2015, 9:4793-4805

Published Date: 19 August 2015

High glucose inhibits ClC-2 chloride channels and attenuates cell migration of rat keratinocytes

Pan F, Guo R, Cheng W, Chai L, Wang W, Cao C, Li S

Drug Design, Development and Therapy 2015, 9:4779-4791

Published Date: 28 August 2015

Effects of chalcone derivatives on players of the immune system

Lee JS, Bukhari SNA, Fauzi NM

Drug Design, Development and Therapy 2015, 9:4761-4778

Published Date: 19 August 2015

Death receptor and mitochondria-mediated hepatocyte apoptosis underlies liver dysfunction in rats exposed to organic pollutants from drinking water

Yang GH, Zhou ZW, Cen YL, Gui XL, Zeng QB, Ao YX, Li Q, Wang SR, Li J, Zhang AH

Drug Design, Development and Therapy 2015, 9:4719-4733

Published Date: 18 August 2015

Development of telmisartan in the therapy of spinal cord injury: pre-clinical study in rats

Lin CM, Tsai JT, Chang CK, Cheng JT, Lin JW

Drug Design, Development and Therapy 2015, 9:4709-4717

Published Date: 14 August 2015

Paget’s disease of bone: an osteoimmunological disorder?

Numan MS, Amiable N, Brown JP, Michou L

Drug Design, Development and Therapy 2015, 9:4695-4707

Published Date: 14 August 2015

Enhancement of absorption and bioavailability of echinacoside by verapamil or clove oil

Shen JY, Yang XL, Yang ZL, Kou JP, Li F

Drug Design, Development and Therapy 2015, 9:4685-4693

Published Date: 14 August 2015

Treatment with metformin and a dipeptidyl peptidase-4 inhibitor elevates apelin levels in patients with type 2 diabetes mellitus

Fan YJ, Zhang Y, Li XS, Zheng H, Song YP, Zhang N, Shen CF, Fan XF, Ren FD, Shen JY, Ren GG, Yang JL

Drug Design, Development and Therapy 2015, 9:4679-4683

Published Date: 14 August 2015

Lefty-1 alleviates TGF-β1-induced fibroblast–myofibroblast transdifferentiation in NRK-49F cells

Zhang LJ, Zhang J, Xu CG, Zhou XJ, Wang W, Zheng RP, Hu W, Wu P

Drug Design, Development and Therapy 2015, 9:4669-4678

Published Date: 14 August 2015

Myofibrotic malformation vessels: unique angiodysplasia toward the progression of hemorrhoidal disease

Li SL, Jing FY, Ma LL, Guo LL, Na F, An SL, Ye Y, Yang JM, Bao M, Kang D, Sun XL, Deng YJ

Drug Design, Development and Therapy 2015, 9:4649-4656

Published Date: 13 August 2015

Eliglustat tartrate for the treatment of adults with type 1 Gaucher disease

Bennett LL, Turcotte K

Drug Design, Development and Therapy 2015, 9:4639-4647

Published Date: 18 August 2015

PTEN insufficiency modulates ER+ breast cancer cell cycle progression and increases cell growth in vitro and in vivo

Chiang KC, Chen HY, Hsu SY, Pang JHS, Wang SY, Hsu JT, Yeh TS, Chen LW, Kuo SF, Sun CC, Lee JM, Yeh CN, Juang HH

Drug Design, Development and Therapy 2015, 9:4631-4638

Published Date: 13 August 2015

Pharmacokinetics and bioavailability study of two ondansetron oral soluble film formulations in fasting healthy male Chinese volunteers

Zhu YB, Zhang Q, Zou JJ, Wan M, Zhao Z, Zhu JR

Drug Design, Development and Therapy 2015, 9:4621-4629

Published Date: 12 August 2015

RGD-modified liposomes enhance efficiency of aclacinomycin A delivery: evaluation of their effect in lung cancer

Feng C, Li X, Dong C, Zhang X, Zhang X, Gao Y

Drug Design, Development and Therapy 2015, 9:4613-4620

Published Date: 11 August 2015

Relaxin inhibits cardiac fibrosis and endothelial–mesenchymal transition via the Notch pathway

Zhou X, Chen X, Cai JJ, Chen LZ, Gong YS, Wang LX, Gao Z, Zhang HQ, Huang WJ, Zhou H

Drug Design, Development and Therapy 2015, 9:4599-4611

Published Date: 11 August 2015

Therapeutic designed poly (lactic-co-glycolic acid) cylindrical oseltamivir phosphate-loaded implants impede tumor neovascularization, growth and metastasis in mouse model of human pancreatic carcinoma

Hrynyk M, Ellis JP, Haxho F, Allison S, Steele JAM, Abdulkhalek S, Neufeld RJ, Szewczuk MR

Drug Design, Development and Therapy 2015, 9:4573-4586

Published Date: 10 August 2015

Ceftobiprole for the treatment of pneumonia: a European perspective

Liapikou A, Cillóniz C, Torres A

Drug Design, Development and Therapy 2015, 9:4565-4572

Published Date: 18 August 2015

Effects of amoxicillin/clavulanic acid on the pharmacokinetics of valproic acid

Lee SY, Huh W, Jung JA, Yoo HM, Ko JW, Kim JR

Drug Design, Development and Therapy 2015, 9:4559-4563

Published Date: 10 August 2015

Evaluation of trends of drug-prescribing patterns based on WHO prescribing indicators at outpatient departments of four hospitals in southern Ethiopia

Summoro TS, Gidebo KD, Kanche ZZ, Woticha EW

Drug Design, Development and Therapy 2015, 9:4551-4557

Published Date: 10 August 2015

Navigating the chemical space of dipeptidyl peptidase-4 inhibitors

Shoombuatong W, Prachayasittikul V, Anuwongcharoen N, Songtawee N, Monnor T, Prachayasittikul S, Prachayasittikul V, Nantasenamat C

Drug Design, Development and Therapy 2015, 9:4515-4549

Published Date: 10 August 2015

Clinical development of galunisertib (LY2157299 monohydrate), a small molecule inhibitor of transforming growth factor-beta signaling pathway

Herbertz S, Sawyer JS, Stauber AJ, Gueorguieva I, Driscoll KE, Estrem ST, Cleverly AL, Desaiah D, Guba SC, Benhadji KA, Slapak CA, Lahn MM

Drug Design, Development and Therapy 2015, 9:4479-4499

Published Date: 10 August 2015

Novel targeting of PEGylated liposomes for codelivery of TGF-β1 siRNA and four antitubercular drugs to human macrophages for the treatment of mycobacterial infection: a quantitative proteomic study

Niu NK, Yin JJ, Yang YX, Wang ZL, Zhou ZW, He ZX, Chen XW, Zhang XJ, Duan W, Yang TX, Zhou SF

Drug Design, Development and Therapy 2015, 9:4441-4470

Published Date: 7 August 2015

Transarterial chemoembolization versus hepatic resection in hepatocellular carcinoma treatment: a meta-analysis

Tian X, Dai Y, Wang D, Zhang L, Sui C, Meng F, Jiang S, Liu Y, Jiang Y

Drug Design, Development and Therapy 2015, 9:4431-4440

Published Date: 10 August 2015

High-throughput sequencing of 16S rDNA amplicons characterizes bacterial composition in cerebrospinal fluid samples from patients with purulent meningitis

Liu A, Wang C, Liang Z, Zhou ZW, Wang L, Ma Q, Wang G, Zhou SF, Wang Z

Drug Design, Development and Therapy 2015, 9:4417-4429

Published Date: 7 August 2015

Tongguan capsule ameliorates coronary artery stenosis in a 40-year-old woman

Ma H, Wang L, Huang DZ, Liu GQ, Zhang MZ

Drug Design, Development and Therapy 2015, 9:4413-4416

Published Date: 10 August 2015

High-throughput virtual screening with e-pharmacophore and molecular simulations study in the designing of pancreatic lipase inhibitors

Veeramachaneni GK, Raj KK, Chalasani LM, Bondili JS, Talluri VR

Drug Design, Development and Therapy 2015, 9:4397-4412

Published Date: 6 August 2015

The role of aflibercept in the management of diabetic macular edema

Chang AA, Hong T, Ewe SY, Bahrami B, Broadhead GK

Drug Design, Development and Therapy 2015, 9:4389-4396

Published Date: 6 August 2015

Gamma scintigraphic evaluation of floating gastroretentive tablets of metformin HCl using a combination of three natural polymers in rabbits

Razavi M, Karimian H, Yeong CH, Chung LY, Nyamathulla S, Noordin MI

Drug Design, Development and Therapy 2015, 9:4373-4386

Published Date: 6 August 2015

Glycemic control and antidiabetic drugs in type 2 diabetes mellitus patients with renal complications

Huri HZ, Lim LP, Lim SK

Drug Design, Development and Therapy 2015, 9:4355-4371

Published Date: 7 August 2015

The role of taxanes in triple-negative breast cancer: literature review

Mustacchi G, De Laurentiis M

Drug Design, Development and Therapy 2015, 9:4303-4318

Published Date: 5 August 2015

Hidden costs of antiretroviral treatment: the public health efficiency of drug packaging

Andreu-Crespo À, Llibre JM, Cardona-Peitx G, Sala-Piñol F, Clotet B, Bonafont-Pujol X

Drug Design, Development and Therapy 2015, 9:4287-4290

Published Date: 5 August 2015

Development of megestrol acetate solid dispersion nanoparticles for enhanced oral delivery by using a supercritical antisolvent process

Ha ES, Kim JS, Baek I, Yoo JW, Jung Y, Moon HR, Kim MS

Drug Design, Development and Therapy 2015, 9:4269-4277

Published Date: 4 August 2015

Design, synthesis, and anti-melanogenic effects of (E)-2-benzoyl-3-(substituted phenyl)acrylonitriles

Yun HY, Kim DH, Son S, Ullah S, Kim SJ, Kim YJ, Yoo JW, Jung YJ, Chun P, Moon HR

Drug Design, Development and Therapy 2015, 9:4259-4268

Published Date: 4 August 2015

Colon-targeted delivery of piceatannol enhances anti-colitic effects of the natural product: potential molecular mechanisms for therapeutic enhancement

Yum S, Jeong S, Lee S, Nam J, Kim W, Yoo JW, Kim MS, Lee BL, Jung Y

Drug Design, Development and Therapy 2015, 9:4247-4258

Published Date: 4 August 2015

Advances in cancer pain from bone metastasis

Zhu XC, Zhang JL, Ge CT, Yu YY, Wang P, Yuan TF, Fu CY

Drug Design, Development and Therapy 2015, 9:4239-4245

Published Date: 18 August 2015

Evaluation of glycine-bearing celecoxib derivatives as a colon-specific mutual prodrug acting on nuclear factor-κB, an anti-inflammatory target

Lee S, Lee Y, Kim W, Nam J, Jeong S, Yoo JW, Kim MS, Moon HR, Jung Y

Drug Design, Development and Therapy 2015, 9:4227-4237

Published Date: 7 August 2015

Characterization of cubosomes as a targeted and sustained transdermal delivery system for capsaicin

Peng X, Zhou Y, Han K, Qin L, Dian L, Li G, Pan X, Wu C

Drug Design, Development and Therapy 2015, 9:4209-4218

Published Date: 3 August 2015

Antihypercholesterolemic and antioxidant efficacies of zerumbone on the formation, development, and establishment of atherosclerosis in cholesterol-fed rabbits

Hemn HO, Noordin MM, Rahman HS, Hazilawati H, Zuki A, Chartrand MS

Drug Design, Development and Therapy 2015, 9:4173-4208

Published Date: 3 August 2015

CTGF siRNA ameliorates tubular cell apoptosis and tubulointerstitial fibrosis in obstructed mouse kidneys in a Sirt1-independent manner

Ren Y, Du C, Yan L, Wei J, Wu H, Shi Y, Duan H

Drug Design, Development and Therapy 2015, 9:4155-4171

Published Date: 31 July 2015

Nutrigenomic effects of edible bird’s nest on insulin signaling in ovariectomized rats

Hou ZP, Imam MU, Ismail M, Ooi DJ, Ideris A, Mahmud R

Drug Design, Development and Therapy 2015, 9:4115-4125

Published Date: 14 August 2015

Celecoxib coupled to dextran via a glutamic acid linker yields a polymeric prodrug suitable for colonic delivery

Lee Y, Kim J, Kim W, Nam J, Jeong S, Lee S, Yoo JW, Kim MS, Jung Y

Drug Design, Development and Therapy 2015, 9:4105-4113

Published Date: 30 July 2015

20(S)-ginsenoside Rg3 promotes senescence and apoptosis in gallbladder cancer cells via the p53 pathway

Zhang F, Li M, Wu X, Hu Y, Cao Y, Wang X, Xiang S, Li H, Jiang L, Tan Z, Lu W, Weng H, Shu Y, Gong W, Wang X, Zhang Y, Shi W, Dong P, Gu J, Liu Y

Drug Design, Development and Therapy 2015, 9:3969-3987

Published Date: 10 August 2015

Improved oral absorption of cilostazol via sulfonate salt formation with mesylate and besylate

Seo JH, Park JB, Choi WK, Park S, Sung YJ, Oh E, Bae SK

Drug Design, Development and Therapy 2015, 9:3961-3968

Published Date: 30 July 2015

Edible bird’s nest attenuates procoagulation effects of high-fat diet in rats

Yida Z, Imam MU, Ismail M, Ismail N, Hou ZP

Drug Design, Development and Therapy 2015, 9:3951-3959

Published Date: 29 July 2015

Combined treatment with olmesartan medoxomil and amlodipine besylate attenuates atherosclerotic lesion progression in a model of advanced atherosclerosis

Sievers P, Uhlmann L, Korkmaz-Icöz S, Fastner C, Bea F, Blessing E, Katus HA, Preusch MR

Drug Design, Development and Therapy 2015, 9:3935-3942

Published Date: 29 July 2015

Gallic acid attenuates dextran sulfate sodium-induced experimental colitis in BALB/c mice

Pandurangan AK, Mohebali N, Norhaizan ME, Looi CY

Drug Design, Development and Therapy 2015, 9:3923-3934

Published Date: 30 July 2015

The chemopreventive potential of Curcuma purpurascens rhizome in reducing azoxymethane-induced aberrant crypt foci in rats

Rouhollahi E, Moghadamtousi SZ, Al-Henhena N, Kunasegaran T, Hasanpourghadi M, Looi CY, Abd Malek SN, Awang K, Abdulla MA, Mohamed Z

Drug Design, Development and Therapy 2015, 9:3911-3922

Published Date: 27 July 2015

Zinc supplementation induces apoptosis and enhances antitumor efficacy of docetaxel in non-small-cell lung cancer

Kocdor H, Ates H, Aydin S, Cehreli R, Soyarat F, Kemanli P, Harmanci D, Cengiz H, Kocdor MA

Drug Design, Development and Therapy 2015, 9:3899-3909

Published Date: 27 July 2015

Aterofisiol® in carotid plaque evolution

Amato B, Compagna R, Amato M, Gallelli L, de Franciscis S, Serra R

Drug Design, Development and Therapy 2015, 9:3877-3884

Published Date: 23 July 2015

Dendrimer-coupled sonophoresis-mediated transdermal drug-delivery system for diclofenac

Huang B, Dong WJ, Yang GY, Wang W, Ji CH, Zhou FN

Drug Design, Development and Therapy 2015, 9:3867-3876

Published Date: 23 July 2015

The brain signature of paracetamol in healthy volunteers: a double-blind randomized trial

Pickering G, Kastler A, Macian N, Pereira B, Valabrègue R, Lehericy S, Boyer L, Dubray C, Jean B

Drug Design, Development and Therapy 2015, 9:3853-3862

Published Date: 23 July 2015

Navigating into the binding pockets of the HER family protein kinases: discovery of novel EGFR inhibitor as antitumor agent

Liu W, Ning JF, Meng QW, Hu J, Zhao YB, Liu C, Cai L

Drug Design, Development and Therapy 2015, 9:3837-3851

Published Date: 23 July 2015

Effect of lactoferrin protein on red blood cells and macrophages: mechanism of parasite–host interaction

Anand N, Kanwar RK, Dubey ML, Vahishta RK, Sehgal R, Verma AK, Kanwar JR

Drug Design, Development and Therapy 2015, 9:3821-3835

Published Date: 27 July 2015

A new recombinant factor VIII: from genetics to clinical use

Kannicht C, Kohla G, Tiemeyer M, Walter O, Sandberg H

Drug Design, Development and Therapy 2015, 9:3817-3819

Published Date: 23 July 2015

Developments in managing severe chronic pain: role of oxycodone–naloxone extended release

Fanelli G, Fanelli A

Drug Design, Development and Therapy 2015, 9:3811-3816

Published Date: 22 July 2015

Colon-targeted delivery of budesonide using dual pH- and time-dependent polymeric nanoparticles for colitis therapy

Naeem M, Choi MJ, Cao J, Lee Y, Ikram M, Yoon S, Lee J, Moon HR, Kim MS, Jung YJ, Yoo JW

Drug Design, Development and Therapy 2015, 9:3789-3799

Published Date: 21 July 2015

Design, development, drug-likeness, and molecular docking studies of novel piperidin-4-imine derivatives as antitubercular agents

Revathi R, Venkatesha Perumal R, Pai KSR, Arunkumar G, Sriram D, Kini SG

Drug Design, Development and Therapy 2015, 9:3779-3787

Published Date: 21 July 2015

Albumin-bound paclitaxel in solid tumors: clinical development and future directions

Kundranda MN, Niu J

Drug Design, Development and Therapy 2015, 9:3767-3777

Published Date: 24 July 2015

Escherichia coli Nissle 1917 bacterial ghosts retain crucial surface properties and express chlamydial antigen: an imaging study of a delivery system for the ocular surface

Montanaro J, Inic-Kanada A, Ladurner A, Stein E, Belij S, Bintner N, Schlacher S, Schuerer N, Mayr UB, Lubitz W, Leisch N, Barisani-Asenbauer T

Drug Design, Development and Therapy 2015, 9:3741-3754

Published Date: 21 July 2015

Clinicopathological significance of matrix metalloproteinase-7 protein expression in esophageal cancer: a meta-analysis

Miao S, Zhou SY, Han CS, Zhang LN, Sun HB, Yang B

Drug Design, Development and Therapy 2015, 9:3729-3740

Published Date: 20 July 2015

Targeting brain cells with glutathione-modulated nanoliposomes: in vitro and in vivo study

Salem HF, Ahmed SM, Hassaballah AE, Omar MM

Drug Design, Development and Therapy 2015, 9:3705-3727

Published Date: 20 July 2015

Mechanisms underlying probucol-induced hERG-channel deficiency

Shi YQ, Yan CC, Zhang X, Yan M, Liu LR, Geng HZ, Lv L, Li BX

Drug Design, Development and Therapy 2015, 9:3695-3704

Published Date: 20 July 2015

Relationship between UGT1A1*6/*28 polymorphisms and severe toxicities in Chinese patients with pancreatic or biliary tract cancer treated with irinotecan-containing regimens

Yang C, Liu Y, Xi WQ, Zhou CF, Jiang JL, Ma T, Ye ZB, Zhang J, Zhu ZG

Drug Design, Development and Therapy 2015, 9:3677-3683

Published Date: 17 July 2015

Treatment of Staphylococcus aureus-induced chronic osteomyelitis with bone-like hydroxyapatite/poly amino acid loaded with rifapentine microspheres

Yan L, Jiang DM, Cao ZD, Wu J, Wang X, Wang ZL, Li YJ, Yi YF

Drug Design, Development and Therapy 2015, 9:3665-3676

Published Date: 16 July 2015

Synthesis, antimicrobial and in vitro antitumor activities of a series of 1,2,3-thiadiazole and 1,2,3-selenadiazole derivatives

Mhaidat NM, Al-Smadi M, Al-Momani F, Alzoubi KH, Mansi I, Al-Balas Q

Drug Design, Development and Therapy 2015, 9:3645-3652

Published Date: 16 July 2015

2-acetylphenol analogs as potent reversible monoamine oxidase inhibitors

Legoabe LJ, Petzer A, Petzer JP

Drug Design, Development and Therapy 2015, 9:3635-3644

Published Date: 15 July 2015

A meta-analysis for C-X-C chemokine receptor type 4 as a prognostic marker and potential drug target in hepatocellular carcinoma

Hu F, Miao L, Zhao Y, Xiao YY, Xu Q

Drug Design, Development and Therapy 2015, 9:3625-3633

Published Date: 15 July 2015

Downregulation of miR203 induces overexpression of PIK3CA and predicts poor prognosis of gastric cancer patients

Liang M, Shi B, Liu J, He L, Yi G, Zhou L, Yu G, Zhou X

Drug Design, Development and Therapy 2015, 9:3607-3616

Published Date: 16 July 2015

Depot injectable biodegradable nanoparticles loaded with recombinant human bone morphogenetic protein-2: preparation, characterization, and in vivo evaluation

Hassan AH, Hosny KM, Murshid ZA, Alhadlaq A, Alyamani A, Naguib G

Drug Design, Development and Therapy 2015, 9:3599-3606

Published Date: 13 July 2015

Apparent Km of mitochondria for oxygen computed from Vmax measured in permeabilized muscle fibers is lower in water enriched in oxygen by electrolysis than injection

Zoll J, Bouitbir J, Sirvent P, Klein A, Charton A, Jimenez L, Péronnet FR, Geny B, Richard R

Drug Design, Development and Therapy 2015, 9:3589-3597

Published Date: 13 July 2015

Wound healing: a new perspective on glucosylated tetrahydrocurcumin

Bhaskar Rao A, Prasad E, Deepthi SS, Haritha V, Ramakrishna S, Madhusudan K, Surekha MV, Venkata Rao YSR

Drug Design, Development and Therapy 2015, 9:3579-3588

Published Date: 13 July 2015

Pharmacokinetic comparison of sustained- and immediate-release formulations of cilostazol after multiple oral doses in fed healthy male Korean volunteers

Kim YH, Ghim JL, Jung JA, Cho SH, Choe S, Choi HY, Bae KS, Lim HS

Drug Design, Development and Therapy 2015, 9:3571-3577

Published Date: 9 July 2015

Dolutegravir – a review of the pharmacology, efficacy, and safety in the treatment of HIV

Kandel CE, Walmsley SL

Drug Design, Development and Therapy 2015, 9:3547-3555

Published Date: 7 July 2015

Pancreatic cancer: optimizing treatment options, new, and emerging targeted therapies

Chiorean EG, Coveler AL

Drug Design, Development and Therapy 2015, 9:3529-3545

Published Date: 7 July 2015

Reverse phase protein arrays in signaling pathways: a data integration perspective

Creighton CJ, Huang S

Drug Design, Development and Therapy 2015, 9:3519-3527

Published Date: 7 July 2015

Effect of Clausena excavata Burm. f. (Rutaceae) leaf extract on wound healing and antioxidant activity in rats

Albaayit SFA, Abba Y, Rasedee A, Abdullah N

Drug Design, Development and Therapy 2015, 9:3507-3518

Published Date: 13 July 2015

Phenolic indeno[1,2-b]indoles as ABCG2-selective potent and non-toxic inhibitors stimulating basal ATPase activity

Gozzi GJ, Bouaziz Z, Winter E, Daflon-Yunes N, Honorat M, Guragossian N, Marminon C, Valdameri G, Bollacke A, Guillon J, Pinaud N, Marchivie M, Cadena SM, Jose J, Le Borgne M, Di Pietro A

Drug Design, Development and Therapy 2015, 9:3481-3495

Published Date: 3 July 2015

Adaptive evolution and elucidating the potential inhibitor against schizophrenia to target DAOA (G72) isoforms

Sehgal SA, Mannan S, Kanwal S, Naveed I, Mir A

Drug Design, Development and Therapy 2015, 9:3471-3480

Published Date: 3 July 2015

Selective use of vandetanib in the treatment of thyroid cancer

Fallahi P, Di Bari F, Ferrari SM, Spisni R, Materazzi G, Miccoli P, Benvenga S, Antonelli A

Drug Design, Development and Therapy 2015, 9:3459-3470

Published Date: 3 July 2015

Siltuximab (CNTO 328): a promising option for human malignancies

Chen R, Chen B

Drug Design, Development and Therapy 2015, 9:3455-3458

Published Date: 2 July 2015

Animal models of ischemic stroke and their application in clinical research

Fluri F, Schuhmann MK, Kleinschnitz C

Drug Design, Development and Therapy 2015, 9:3445-3454

Published Date: 2 July 2015

Evaluation of the efficacy and safety of three dosing regimens of agalsidase alfa enzyme replacement therapy in adults with Fabry disease

Goláň L, Goker-Alpan O, Holida M, Kantola I, Klopotowski M, Kuusisto J, Linhart A, Musial J, Nicholls K, Gonzalez-Rodriguez D, Sharma R, Vujkovac B, Chang P, Wijatyk A

Drug Design, Development and Therapy 2015, 9:3435-3444

Published Date: 8 July 2015

Pharmacokinetics, pharmacodynamics, and safety of lesinurad, a selective uric acid reabsorption inhibitor, in healthy adult males

Shen Z, Rowlings C, Kerr B, Hingorani V, Manhard K, Quart B, Yeh LT, Storgard C

Drug Design, Development and Therapy 2015, 9:3423-3434

Published Date: 2 July 2015

Effect of vitamin C on inflammation and metabolic markers in hypertensive and/or diabetic obese adults: a randomized controlled trial

Ellulu MS, Rahmat A, Patimah I, Khaza’ai H, Abed Y

Drug Design, Development and Therapy 2015, 9:3405-3412

Published Date: 1 July 2015

Scientometrics of drug discovery efforts: pain-related molecular targets

Kissin I

Drug Design, Development and Therapy 2015, 9:3393-3404

Published Date: 1 July 2015

Discovery of 3-n-butyl-2,3-dihydro-1H-isoindol-1-one as a potential anti-ischemic stroke agent

Lan Z, Xu X, Xu W, Li J, Liang Z, Zhang X, Lei M, Zhao C

Drug Design, Development and Therapy 2015, 9:3377-3391

Published Date: 30 June 2015

Pirfenidone-loaded liposomes for lung targeting: preparation and in vitro/in vivo evaluation

Meng H, Xu Y

Drug Design, Development and Therapy 2015, 9:3369-3376

Published Date: 30 June 2015

Dose-dependent effects of atorvastatin on myocardial infarction

Barbarash O, Gruzdeva O, Uchasova E, Belik E, Dyleva Y, Karetnikova V

Drug Design, Development and Therapy 2015, 9:3361-3368

Published Date: 29 June 2015

Innovation of natural essential oil-loaded Orabase for local treatment of oral candidiasis

Labib GS, Aldawsari H

Drug Design, Development and Therapy 2015, 9:3349-3359

Published Date: 29 June 2015

The role of Gliadel wafers in the treatment of newly diagnosed GBM: a meta-analysis

Xing WK, Shao C, Qi ZY, Yang C, Wang Z

Drug Design, Development and Therapy 2015, 9:3341-3348

Published Date: 29 June 2015

Enzalutamide for the treatment of metastatic castration-resistant prostate cancer

Rodriguez-Vida A, Galazi M, Rudman S, Chowdhury S, Sternberg CN

Drug Design, Development and Therapy 2015, 9:3325-3339

Published Date: 29 June 2015

Exploration of natural product ingredients as inhibitors of human HMG-CoA reductase through structure-based virtual screening

Lin SH, Huang KJ, Weng CF, Shiuan D

Drug Design, Development and Therapy 2015, 9:3313-3324

Published Date: 26 June 2015

Effect of renal impairment on the pharmacokinetics of levomilnacipran following a single oral dose of levomilnacipran extended-release capsule in humans

Chen L, Greenberg WM, Brand-Schieber E, Wangsa J, Periclou A, Ghahramani P

Drug Design, Development and Therapy 2015, 9:3293-3300

Published Date: 25 June 2015

Animal models of polymicrobial pneumonia

Hraiech S, Papazian L, Rolain JM, Bregeon F

Drug Design, Development and Therapy 2015, 9:3279-3292

Published Date: 26 June 2015

A meta-analysis for CXCR4 as a prognostic marker and potential drug target in non-small cell lung cancer

Zhang C, Li J, Han Y, Jiang J

Drug Design, Development and Therapy 2015, 9:3267-3278

Published Date: 24 June 2015

Development of biosimilars in an era of oncologic drug shortages

Li E, Subramanian J, Anderson S, Thomas D, McKinley J, Jacobs IA

Drug Design, Development and Therapy 2015, 9:3247-3255

Published Date: 24 June 2015

Sphingosine kinase 1 as an anticancer therapeutic target

Gao Y, Gao F, Chen K, Tian ML, Zhao DL

Drug Design, Development and Therapy 2015, 9:3239-3245

Published Date: 23 June 2015

Design of a gelatin microparticle-containing self-microemulsifying formulation for enhanced oral bioavailability of dutasteride

Baek I, Ha ES, Yoo JW, Jung Y, Kim MS

Drug Design, Development and Therapy 2015, 9:3231-3238

Published Date: 23 June 2015

Simvastatin prevents isoproterenol-induced cardiac hypertrophy through modulation of the JAK/STAT pathway

Al-Rasheed NM, Al-Oteibi MM, Al-Manee RZ, Al-Shareef SA, Al-Rasheed NM, Hasan IH, Mohamad RA, Mahmoud AM

Drug Design, Development and Therapy 2015, 9:3217-3229

Published Date: 23 June 2015

Disposition and metabolism of [14C]-levomilnacipran, a serotonin and norepinephrine reuptake inhibitor, in humans, monkeys, and rats

Brunner V, Maynadier B, Chen L, Roques L, Hude I, Séguier S, Barthe L, Hermann P

Drug Design, Development and Therapy 2015, 9:3199-3215

Published Date: 23 June 2015

Characterization of renal biomarkers for use in clinical trials: effect of preanalytical processing and qualification using samples from subjects with diabetes

Brott DA, Furlong ST, Adler SH, Hainer JW, Arani RB, Pinches M, Rossing P, Chaturvedi N

Drug Design, Development and Therapy 2015, 9:3191-3198

Published Date: 22 June 2015

Combination of erlotinib and a PARP inhibitor inhibits growth of A2780 tumor xenografts due to increased autophagy

Sui H, Shi C, Yan Z, Li H

Drug Design, Development and Therapy 2015, 9:3183-3190

Published Date: 22 June 2015

The impact of lipocalin-type-prostaglandin-D-synthase as a predictor of kidney disease in patients with type 2 diabetes

Bacci MR, Cavallari MR, de Rozier-Alves RM, Alves BCA, Fonseca FLA

Drug Design, Development and Therapy 2015, 9:3179-3182

Published Date: 22 June 2015

Histone demethylase LSD1-mediated repression of GATA-2 is critical for erythroid differentiation

Guo Y, Fu X, Jin Y, Sun J, Liu Y, Huo B, Li X, Hu X

Drug Design, Development and Therapy 2015, 9:3153-3162

Published Date: 19 June 2015

Gamma scintigraphic study of the hydrodynamically balanced matrix tablets of Metformin HCl in rabbits

Razavi M, Karimian H, Yeong CH, Sarji SA, Chung LY, Nyamathulla S, Noordin MI

Drug Design, Development and Therapy 2015, 9:3125-3139

Published Date: 19 June 2015

Anticancer activity of Nigella sativa (black seed) and its relationship with the thermal processing and quinone composition of the seed

Agbaria R, Gabarin A, Dahan A, Ben-Shabat S

Drug Design, Development and Therapy 2015, 9:3119-3124

Published Date: 18 June 2015

Insulin administration: present strategies and future directions for a noninvasive (possibly more physiological) delivery

Matteucci E, Giampietro O, Covolan V, Giustarini D, Fanti P, Rossi R

Drug Design, Development and Therapy 2015, 9:3109-3118

Published Date: 17 June 2015

Phase II study of reintroduction of oxaliplatin for advanced colorectal cancer in patients previously treated with oxaliplatin and irinotecan: RE-OPEN study

Suenaga M, Mizunuma N, Matsusaka S, Shinozaki E, Ozaka M, Ogura M, Yamaguchi T

Drug Design, Development and Therapy 2015, 9:3099-3108

Published Date: 16 June 2015

Inhibition of cyclooxygenase-2 prevents intra-abdominal adhesions by decreasing activity of peritoneal fibroblasts

Wei G, Chen X, Wang G, Jia P, Xu Q, Ping G, Wang K, Li X

Drug Design, Development and Therapy 2015, 9:3083-3098

Published Date: 15 June 2015

Profile of evolocumab and its potential in the treatment of hyperlipidemia

Cicero AF, Colletti A, Borghi C

Drug Design, Development and Therapy 2015, 9:3073-3082

Published Date: 15 June 2015

Antibiotic-modifying activity of riachin, a non-cyanogenic cyanoglycoside extracted from Bauhinia pentandra

Farias PAM, Figueredo FG, Lucas AMB, Moura RB, Coutinho HDM, Silva TMS, Martin ALAR, Fonteles MMF

Drug Design, Development and Therapy 2015, 9:3067-3072

Published Date: 15 June 2015

Cardioprotection against ischemia/reperfusion injury by QiShenYiQi Pill® via ameliorate of multiple mitochondrial dysfunctions

Chen JR, Wei J, Wang LY, Zhu Y, Li L, Olunga MA, Gao XM, Fan GW

Drug Design, Development and Therapy 2015, 9:3051-3066

Published Date: 15 June 2015

Efficiency and safety of subconjunctival injection of anti-VEGF agent – bevacizumab – in treating dry eye

Jiang X, Lv H, Qiu W, Liu Z, Li X, Wang W

Drug Design, Development and Therapy 2015, 9:3043-3050

Published Date: 12 June 2015

Effect of database profile variation on drug safety assessment: an analysis of spontaneous adverse event reports of Japanese cases

Nomura K, Takahashi K, Hinomura Y, Kawaguchi G, Matsushita Y, Marui H, Anzai T, Hashiguchi M, Mochizuki M

Drug Design, Development and Therapy 2015, 9:3031-3041

Published Date: 12 June 2015

Oleanolic acid induces mitochondrial-dependent apoptosis and G0/G1 phase arrest in gallbladder cancer cells

Li HF, Wang XA, Xiang SS, Hu YP, Jiang L, Shu YJ, Li ML, Wu XS, Zhang F, Ye YY, Weng H, Bao RF, Cao Y, Lu W, Dong Q, Liu YB

Drug Design, Development and Therapy 2015, 9:3017-3030

Published Date: 12 June 2015

Osteopontin promotes dendritic cell maturation and function in response to HBV antigens

Cui GY, Chen JN, He JQ, Lu C, Wei YF, Wang L, Xu XJ, Li LJ, Uede T, Diao HY

Drug Design, Development and Therapy 2015, 9:3003-3016

Published Date: 12 June 2015

Assessment of hydroxychloroquine maculopathy after cessation of treatment: an optical coherence tomography and multifocal electroretinography study

Moschos MM, Nitoda E, Chatziralli IP, Gatzioufas Z, Koutsandrea C, Kitsos G

Drug Design, Development and Therapy 2015, 9:2993-2999

Published Date: 11 June 2015

Protective effect of galangin in Concanavalin A- induced hepatitis in mice

Luo Q, Zhu L, Ding J, Zhuang X, Xu L, Chen F

Drug Design, Development and Therapy 2015, 9:2983-2992

Published Date: 10 June 2015

Oxidant/antioxidant status, paraoxonase activity, and lipid profile in plasma of ovariectomized rats under the influence of estrogen, estrogen combined with progesterone, and genistein

Agacayak E, Basaranoglu S, Tunc SY, Icen MS, Findik FM, Kaplan I, Evliyaoglu O, Gul T

Drug Design, Development and Therapy 2015, 9:2975-2982

Published Date: 10 June 2015

Immunostimulatory effects of the standardized extract of Tinospora crispa on innate immune responses in Wistar Kyoto rats

Ahmad W, Jantan I, Kumolosasi E, Abbas Bukhari SN

Drug Design, Development and Therapy 2015, 9:2961-2973

Published Date: 10 June 2015

Inflammation, cytokines, the IL-17/IL-6/STAT3/NF-κB axis, and tumorigenesis

Chen XW, Zhou SF

Drug Design, Development and Therapy 2015, 9:2941-2946

Published Date: 8 June 2015

Cissus quadrangularis inhibits IL-1β induced inflammatory responses on chondrocytes and alleviates bone deterioration in osteotomized rats via p38 MAPK signaling

Kanwar JR, Samarasinghe RM, Kumar K, Arya R, Sharma S, Zhou SF, Sasidharan S, Kanwar RK

Drug Design, Development and Therapy 2015, 9:2927-2940

Published Date: 5 June 2015

Small-molecule BH3 mimetic and pan-Bcl-2 inhibitor AT-101 enhances the antitumor efficacy of cisplatin through inhibition of APE1 repair and redox activity in non-small-cell lung cancer

Ren T, Shan J, Li M, Qing Y, Qian C, Wang G, Li Q, Lu G, Li C, Peng Y, Luo H, Zhang S, Yang Y, Cheng Y, Wang D, Zhou SF

Drug Design, Development and Therapy 2015, 9:2887-2910

Published Date: 8 June 2015

Spotlight on pembrolizumab in the treatment of advanced melanoma

Rajakulendran T, Adam DN

Drug Design, Development and Therapy 2015, 9:2883-2886

Published Date: 4 June 2015

Protective effect of Huang Gan formula in 5/6 nephrectomized rats by depressing the Wnt/β-catenin signaling pathway

Mo LQ, Xiao XY, Song SL, Miao H, Liu ST, Guo D, Li X, Bu C, Hou LB, Yang XX

Drug Design, Development and Therapy 2015, 9:2867-2881

Published Date: 3 June 2015

Efficacy of fimasartan/hydrochlorothiazide combination in hypertensive patients inadequately controlled by fimasartan monotherapy

Rhee MY, Baek SH, Kim W, Park CG, Park SW, Oh BH, Kim SH, Kim JJ, Shin JH, Yoo BS, Rim SJ, Ha JW, Doh JH, Ahn Y, Chae JK, Park JB, Kim SK, Kim CH

Drug Design, Development and Therapy 2015, 9:2847-2854

Published Date: 2 June 2015

Cost-effectiveness analysis of lamivudine, telbivudine, and entecavir in treatment of chronic hepatitis B with adefovir dipivoxil resistance

Wang G, Liu Y, Qiu P, Zhou SF, Xu L, Wen P, Wen J, Xiao X

Drug Design, Development and Therapy 2015, 9:2839-2846

Published Date: 2 June 2015

Applications of calixarenes in cancer chemotherapy: facts and perspectives

Yousaf A, Abd Hamid S, Bunnori NM, Ishola AA

Drug Design, Development and Therapy 2015, 9:2831-2838

Published Date: 2 June 2015

Neuroprotective and antioxidant effects of ghrelin in an experimental glaucoma model

Can N, Catak O, Turgut B, Demir T, Ilhan N, Kuloglu T, Ozercan IH

Drug Design, Development and Therapy 2015, 9:2819-2829

Published Date: 2 June 2015

Itraconazole solid dispersion prepared by a supercritical fluid technique: preparation, in vitro characterization, and bioavailability in beagle dogs

Yin X, Daintree LS, Ding S, Ledger DM, Wang B, Zhao W, Qi J, Wu W

Drug Design, Development and Therapy 2015, 9:2801-2810

Published Date: 28 May 2015

Isolation and evaluation of anticancer efficacy of stigmasterol in a mouse model of DMBA-induced skin carcinoma

Ali H, Dixit S, Ali D, Alqahtani SM, Alkahtani S, Alarifi S

Drug Design, Development and Therapy 2015, 9:2793-2800

Published Date: 28 May 2015

Role of sodium tungstate as a potential antiplatelet agent

Fernández-Ruiz R, Pino M, Hurtado B, García de Frutos P, Caballo C, Escolar G, Gomis R, Diaz-Ricart M

Drug Design, Development and Therapy 2015, 9:2777-2786

Published Date: 26 May 2015

Combination therapy of fenofibrate and ursodeoxycholic acid in patients with primary biliary cirrhosis who respond incompletely to UDCA monotherapy: a meta-analysis

Zhang Y, Li S, He L, Wang F, Chen K, Li J, Liu T, Zheng Y, Wang J, Lu W, Zhou Y, Yin Q, Xia Y, Zhou Y, Lu J, Guo C

Drug Design, Development and Therapy 2015, 9:2757-2766

Published Date: 25 May 2015

Antitumor effects of traditional Chinese medicine targeting the cellular apoptotic pathway

Xu HL, Zhao X, Liu XH, Xu PX, Zhang KM, Lin XK

Drug Design, Development and Therapy 2015, 9:2735-2744

Published Date: 21 May 2015

Effects of strontium ranelate on bone formation in the mid-palatal suture after rapid maxillary expansion

Zhao SY, Wang XX, Li N, Chen Y, Su YR, Zhang J

Drug Design, Development and Therapy 2015, 9:2725-2734

Published Date: 21 May 2015

Synthesis and characterization of tumor-targeted copolymer nanocarrier modified by transferrin

Liu R, Wang Y, Li X, Bao W, Xia G, Chen W, Cheng J, Xu Y, Guo L, Chen B

Drug Design, Development and Therapy 2015, 9:2705-2719

Published Date: 22 May 2015

Anti-Warburg effect of rosmarinic acid via miR-155 in gastric cancer cells

Han S, Yang SH, Cai Z, Pan DY, Li Z, Huang ZH, Zhang PS, Zhu HJ, Lei LJ, Wang WW

Drug Design, Development and Therapy 2015, 9:2695-2703

Published Date: 19 May 2015

Impact of JAK2(V617F) mutation status on treatment response to anagrelide in essential thrombocythemia: an observational, hypothesis-generating study

Cascavilla N, De Stefano V, Pane F, Pancrazzi A, Iurlo A, Gobbi M, Palandri F, Specchia G, Liberati AM, D’Adda M, Gaidano G, Fjerza R, Achenbach H, Smith J, Wilde P, Vannucchi AM

Drug Design, Development and Therapy 2015, 9:2687-2694

Published Date: 18 May 2015

The usefulness of ozone treatment in spinal pain

Bocci V, Borrelli E, Zanardi I, Travagli V

Drug Design, Development and Therapy 2015, 9:2677-2685

Published Date: 15 May 2015

A thorough QT study to assess the effects of tbo-filgrastim on cardiac repolarization in healthy subjects

Adar L, Avisar N, Lammerich A, Kleiman RB, Spiegelstein O

Drug Design, Development and Therapy 2015, 9:2653-2662

Published Date: 15 May 2015

Construction of interference vector targeting Ep-CAM gene and its effects on colorectal cancer cell proliferation

Qi Y, Zhou F, Zhang L, Liu L, Xu H, Guo H

Drug Design, Development and Therapy 2015, 9:2647-2652

Published Date: 14 May 2015

A study on the hemocompatibility of dendronized chitosan derivatives in red blood cells

Zhou YF, Li JM, Lu F, Deng JJ, Zhang JH, Fang PJ, Peng XS, Zhou SF

Drug Design, Development and Therapy 2015, 9:2635-2645

Published Date: 14 May 2015

Prevalence of the CYP2D6*10 (C100T), *4 (G1846A), and *14 (G1758A) alleles among Iranians of different ethnicities

Bagheri A, Kamalidehghan B, Haghshenas M, Azadfar P, Akbari L, Sangtarash MH, Vejdandoust F, Ahmadipour F, Meng GY, Houshmand M

Drug Design, Development and Therapy 2015, 9:2627-2634

Published Date: 13 May 2015

A pharmacokinetic comparison of two voriconazole formulations and the effect of CYP2C19 polymorphism on their pharmacokinetic profiles

Chung H, Lee H, Han H, An H, Lim KS, Lee YJ, Cho JY, Yoon SH, Jang IJ, Yu KS

Drug Design, Development and Therapy 2015, 9:2609-2616

Published Date: 13 May 2015

Skin regeneration in deep second-degree scald injuries either by infusion pumping or topical application of recombinant human erythropoietin gel

Giri P, Ebert S, Braumann UD, Kremer M, Giri S, Machens HG, Bader A

Drug Design, Development and Therapy 2015, 9:2565-2579

Published Date: 11 May 2015

Aging-related rotenone-induced neurochemical and behavioral deficits: role of SIRT2 and redox imbalance, and neuroprotection by AK-7

Wang X, Guan Q, Wang M, Yang L, Bai J, Yan Z, Zhang Y, Liu Z

Drug Design, Development and Therapy 2015, 9:2553-2563

Published Date: 7 May 2015

The mazEF toxin–antitoxin system as an attractive target in clinical isolates of Enterococcus faecium and Enterococcus faecalis

Soheili S, Ghafourian S, Sekawi Z, Neela VK, Sadeghifard N, Taherikalani M, Khosravi A, Ramli R, Hamat RA

Drug Design, Development and Therapy 2015, 9:2553-2561

Published Date: 8 May 2015

Sonodynamic effect of hematoporphyrin monomethyl ether on ligature-induced periodontitis in rats

Zhuang DS, Han JL, Bi LJ, Wang YP, Hao YR, Zhou Q, Cao WW

Drug Design, Development and Therapy 2015, 9:2545-2551

Published Date: 6 May 2015

A prospective treatment for sepsis

Shahidi Bonjar MR, Shahidi Bonjar L

Drug Design, Development and Therapy 2015, 9:2537-2543

Published Date: 6 May 2015

Efficacy and safety of different doses of a slow-release corticosteroid implant for macular edema: meta-analysis of randomized controlled trials

Liu QY, He MM, Shi H, Wang QY, Du YR, Liu JL, Ren CD, Xu D, Yu J

Drug Design, Development and Therapy 2015, 9:2527-2535

Published Date: 5 May 2015

Preparation and characterization of genipin-cross-linked silk fibroin/chitosan sustained-release microspheres

Zeng SG, Ye MW, Qiu JQ, Fang W, Rong MD, Guo ZH, Gao WF

Drug Design, Development and Therapy 2015, 9:2501-2514

Published Date: 4 May 2015

Body protective compound-157 enhances alkali-burn wound healing in vivo and promotes proliferation, migration, and angiogenesis in vitro

Huang T, Zhang K, Sun L, Xue X, Zhang C, Shu Z, Mu N, Gu J, Zhang W, Wang Y, Zhang Y, Zhang W

Drug Design, Development and Therapy 2015, 9:2485-2499

Published Date: 30 April 2015

Enhanced anti-inflammatory potential of cinnamate-zinc layered hydroxide in lipopolysaccharide-stimulated RAW 264.7 macrophages

Adewoyin M, Mohsin SMN, Arulselvan P, Hussein MZ, Fakurazi S

Drug Design, Development and Therapy 2015, 9:2475-2484

Published Date: 30 April 2015

Preparation and clinical evaluation of nano-transferosomes for treatment of erectile dysfunction

Ali MFM, Salem HF, Abdelmohsen HF, Attia SK

Drug Design, Development and Therapy 2015, 9:2431-2447

Published Date: 29 April 2015

Pharmacokinetics of mitragynine in man

Trakulsrichai S, Sathirakul K, Auparakkitanon S, Krongvorakul J, Sueajai J, Noumjad N, Sukasem C, Wananukul W

Drug Design, Development and Therapy 2015, 9:2421-2429

Published Date: 29 April 2015

Ultrasound contrast agent loaded with nitric oxide as a theranostic microdevice

Grishenkov D, Gonon A, Weitzberg E, Lundberg JO, Harmark J, Cerroni B, Paradossi G, Janerot-Sjoberg B

Drug Design, Development and Therapy 2015, 9:2409-2419

Published Date: 29 April 2015

Wnt blockers inhibit the proliferation of lung cancer stem cells

Zhang X, Lou Y, Zheng X, Wang H, Sun J, Dong Q, Han B

Drug Design, Development and Therapy 2015, 9:2399-2407

Published Date: 28 April 2015

Development of acquired factor V inhibitor after treatment with ceftazidime: a case report and review of the literature

Cui QY, Shen HS, Wu TQ, Chen HF, Yu ZQ, Wang ZY

Drug Design, Development and Therapy 2015, 9:2395-2398

Published Date: 24 April 2015

Structure–activity exploration of a small-molecule Lipid II inhibitor

Fletcher S, Yu W, Huang J, Kwasny SM, Chauhan J, Opperman TJ, MacKerell Jr AD, de Leeuw EPH

Drug Design, Development and Therapy 2015, 9:2383-2394

Published Date: 24 April 2015

Comparative fasting bioavailability of two clopidogrel formulations in healthy Mediterranean volunteers: an in vitro–in vivo correlation

Zaid AN, Al Ramahi R, Bustami R, Mousa A, Khasawneh S

Drug Design, Development and Therapy 2015, 9:2359-2365

Published Date: 24 April 2015

Critical appraisal of bevacizumab in the treatment of ovarian cancer

Yoshida H, Yabuno A, Fujiwara K

Drug Design, Development and Therapy 2015, 9:2351-2358

Published Date: 28 April 2015

Modifying tetramethyl–nitrophenyl–imidazoline with amino acids: design, synthesis, and 3D-QSAR for improving inflammatory pain therapy

Jiang X, Wang Y, Zhu H, Wang Y, Zhao M, Zhao S, Wu J, Li S, Peng S

Drug Design, Development and Therapy 2015, 9:2329-2342

Published Date: 22 April 2015

A novel glycyrrhetinic acid-modified oxaliplatin liposome for liver-targeting and in vitro/vivo evaluation

Chen J, Jiang H, Wu Y, Li Y, Gao Y

Drug Design, Development and Therapy 2015, 9:2265-2275

Published Date: 20 April 2015

HDACiDB: a database for histone deacetylase inhibitors

Murugan K, Sangeetha S, Ranjitha S, Vimala A, Al-Sohaibani S, Rameshkumar G

Drug Design, Development and Therapy 2015, 9:2257-2264

Published Date: 20 April 2015

Anticancer activity of streptochlorin, a novel antineoplastic agent, in cholangiocarcinoma

Kwak TW, Shin HJ, Jeong YI, Han ME, Oh SO, Kim HJ, Kim DH, Kang DH

Drug Design, Development and Therapy 2015, 9:2201-2214

Published Date: 16 April 2015

Nanoparticle albumin-bound paclitaxel (nab-paclitaxel) as second-line chemotherapy in HER2-negative, taxane-pretreated metastatic breast cancer patients: prospective evaluation of activity, safety, and quality of life

Palumbo R, Sottotetti F, Trifirò G, Piazza E, Ferzi A, Gambaro A, Spinapolice EG, Pozzi E, Tagliaferri B, Teragni C, Bernardo A

Drug Design, Development and Therapy 2015, 9:2189-2199

Published Date: 15 April 2015

Evaluation of combined famotidine with quercetin for the treatment of peptic ulcer: in vivo animal study

Abourehab MA, Khaled KA, Sarhan HA, Ahmed OA

Drug Design, Development and Therapy 2015, 9:2159-2169

Published Date: 13 April 2015

The clinicopathological significance of CDH1 in gastric cancer: a meta-analysis and systematic review

Zeng W, Zhu J, Shan L, Han Z, Aerxiding P, Quhai A, Zeng F, Wang Z, Li H

Drug Design, Development and Therapy 2015, 9:2149-2157

Published Date: 13 April 2015

Paclitaxel attenuates renal interstitial fibroblast activation and interstitial fibrosis by inhibiting STAT3 signaling

Zhang L, Xu X, Yang R, Chen J, Wang S, Yang JQ, Xiang X, He Z, Zhao Y, Dong Z, Zhang D

Drug Design, Development and Therapy 2015, 9:2139-2148

Published Date: 15 April 2015

D-cycloserine augmentation in behavioral therapy for obsessive-compulsive disorder: a meta-analysis

Xia J, Du Y, Han J, Liu G, Wang X

Drug Design, Development and Therapy 2015, 9:2101-2117

Published Date: 21 April 2015

Management of severe sepsis: advances, challenges, and current status

Martin-Loeches I, Levy MM, Artigas A

Drug Design, Development and Therapy 2015, 9:2079-2088

Published Date: 9 April 2015

Impact of potential inappropriate NSAIDs use in chronic pain

Ussai S, Miceli L, Pisa FE, Bednarova R, Giordano A, Della Rocca G, Petelin R

Drug Design, Development and Therapy 2015, 9:2073-2077

Published Date: 9 April 2015

Efficacy and safety of cross-linked hyaluronic acid single injection on osteoarthritis of the knee: a post-marketing phase IV study

Bashaireh K, Naser Z, Hawadya KA, Sorour S, Al-Khateeb RN

Drug Design, Development and Therapy 2015, 9:2063-2072

Published Date: 8 April 2015

Quinoline-based clioquinol and nitroxoline exhibit anticancer activity inducing FoxM1 inhibition in cholangiocarcinoma cells

Chan-on W, Huyen NTB, Songtawee N, Suwanjang W, Prachayasittikul S, Prachayasittikul V

Drug Design, Development and Therapy 2015, 9:2033-2047

Published Date: 8 April 2015

Targeting the hypoxia pathway to treat pancreatic cancer

Erickson LA, Highsmith Jr WE, Fei P, Zhang J

Drug Design, Development and Therapy 2015, 9:2029-2031

Published Date: 8 April 2015

Schisandrin B inhibits cell growth and induces cellular apoptosis and autophagy in mouse hepatocytes and macrophages: implications for its hepatotoxicity

Zhang Y, Zhou ZW, Jin H, Hu C, He ZX, Yu ZL, Ko KM, Yang T, Zhang X, Pan SY, Zhou SF

Drug Design, Development and Therapy 2015, 9:2001-2027

Published Date: 9 April 2015

The effects of amlodipine and platelet rich plasma on bone healing in rats

Atalay Y, Bozkurt MF, Gonul Y, Cakmak O, Agacayak KS, Köse I, Hazman O, Keles H, Turamanlar O, Eroglu M

Drug Design, Development and Therapy 2015, 9:1973-1981

Published Date: 7 April 2015

Gelatin nanoparticle-mediated intranasal delivery of substance P protects against 6-hydroxydopamine-induced apoptosis: an in vitro and in vivo study

Lu CT, Jin RR, Jiang YN, Lin Q, Yu WZ, Mao KL, Tian FR, Zhao YP, Zhao YZ

Drug Design, Development and Therapy 2015, 9:1955-1962

Published Date: 7 April 2015

Impact of enzyme replacement therapy and hematopoietic stem cell transplantation in patients with Morquio A syndrome

Tomatsu S, Sawamoto K, Alméciga-Díaz CJ, Shimada T, Bober MB, Chinen Y, Yabe H, Montaño AM, Giugliani R, Kubaski F, Yasuda E, Rodríguez-López A, Espejo-Mojica AJ, Sánchez OF, Mason RW, Barrera LA, Mackenzie WG, Orii T

Drug Design, Development and Therapy 2015, 9:1937-1953

Published Date: 1 April 2015

Comparative efficacy, acceptability, and tolerability of lisdexamfetamine in child and adolescent ADHD: a meta-analysis of randomized, controlled trials

Maneeton B, Maneeton N, Likhitsathian S, Suttajit S, Narkpongphun A, Srisurapanont M, Woottiluk P

Drug Design, Development and Therapy 2015, 9:1927-1936

Published Date: 1 April 2015

Clinical and pharmacological properties of incobotulinumtoxinA and its use in neurological disorders

Jost WH, Benecke R, Hauschke D, Jankovic J, Kaňovský P, Roggenkämper P, Simpson DM, Comella CL

Drug Design, Development and Therapy 2015, 9:1913-1926

Published Date: 1 April 2015

Liraglutide and obesity: a review of the data so far

Ladenheim EE

Drug Design, Development and Therapy 2015, 9:1867-1875

Published Date: 30 March 2015

Pharmacoinformatics approach for investigation of alternative potential hepatitis C virus nonstructural protein 5B inhibitors

Mirza MU, Ghori NUH, Ikram N, Adil AR, Manzoor S

Drug Design, Development and Therapy 2015, 9:1825-1841

Published Date: 27 March 2015

Paracellular permeation-enhancing effect of AT1002 C-terminal amidation in nasal delivery

Song KH, Kim SB, Shim CK, Chung SJ, Kim DD, Rhee SK, Choi GJ, Kim CH, Kim K

Drug Design, Development and Therapy 2015, 9:1815-1823

Published Date: 27 March 2015

Novel nanoliposomal delivery system for polydatin: preparation, characterization, and in vivo evaluation

Wang X, Guan Q, Chen W, Hu X, Li L

Drug Design, Development and Therapy 2015, 9:1805-1813

Published Date: 30 March 2015

Clinical significance of DAPK promoter hypermethylation in lung cancer: a meta-analysis

Li Y, Zhu M, Zhang X, Cheng D, Ma X

Drug Design, Development and Therapy 2015, 9:1785-1796

Published Date: 24 March 2015

Lost expression of ADAMTS5 protein associates with progression and poor prognosis of hepatocellular carcinoma

Li C, Xiong Y, Yang X, Wang L, Zhang S, Dai N, Li M, Ren T, Yang Y, Zhou SF, Gan L, Wang D

Drug Design, Development and Therapy 2015, 9:1773-1783

Published Date: 24 March 2015

Turoctocog alfa: an evidence-based review of its potential in the treatment of hemophilia A

Takedani H, Hirose J

Drug Design, Development and Therapy 2015, 9:1767-1772

Published Date: 24 March 2015

Design and prediction of new anticoagulants as a selective Factor IXa inhibitor via three-dimensional quantitative structure-property relationships of amidinobenzothiophene derivatives

Gao JS, Tong XP, Chang YQ, He YX, Mei YD, Tan PH, Guo JL, Liao GC, Xiao GK, Chen WM, Zhou SF, Sun PH

Drug Design, Development and Therapy 2015, 9:1743-1759

Published Date: 23 March 2015

Single and multiple dose pharmacokinetics and tolerability of HX-1171, a novel antioxidant, in healthy volunteers

Kim YH, Choi HY, Lee SH, Lim HS, Miki T, Kang JK, Han KG, Bae KS

Drug Design, Development and Therapy 2015, 9:1735-1742

Published Date: 23 March 2015

Glu-Trp-ONa or its acylated analogue (R-Glu-Trp-ONa) administration enhances the wound healing in the model of chronic skin wounds in rabbits

Shevtsov MA, Smagina LV, Kudriavtceva TA, Petlenko SV, Voronkina IV

Drug Design, Development and Therapy 2015, 9:1717-1727

Published Date: 20 March 2015

Human colon carcinogenesis is associated with increased interleukin-17-driven inflammatory responses

Xie Z, Qu Y, Leng Y, Sun W, Ma S, Wei J, Hu J, Zhang X

Drug Design, Development and Therapy 2015, 9:1679-1689

Published Date: 18 March 2015

Synthesis and biological evaluation of a novel class of curcumin analogs as anti-inflammatory agents for prevention and treatment of sepsis in mouse model

Zhao C, Zhang Y, Zou P, Wang J, He W, Shi D, Li H, Liang G, Yang S

Drug Design, Development and Therapy 2015, 9:1663-1678

Published Date: 18 March 2015

A phase I/II study of biweekly capecitabine and irinotecan plus bevacizumab as second-line chemotherapy in patients with metastatic colorectal cancer

Suenaga M, Mizunuma N, Matsusaka S, Shinozaki E, Ozaka M, Ogura M, Chin K, Yamaguchi T

Drug Design, Development and Therapy 2015, 9:1653-1662

Published Date: 16 March 2015

The investigational Aurora kinase A inhibitor alisertib (MLN8237) induces cell cycle G2/M arrest, apoptosis, and autophagy via p38 MAPK and Akt/mTOR signaling pathways in human breast cancer cells

Li JP, Yang YX, Liu QL, Pan ST, He ZX, Zhang X, Yang T, Chen XW, Wang D, Qiu JX, Zhou SF

Drug Design, Development and Therapy 2015, 9:1627-1652

Published Date: 16 March 2015

Plumbagin induces G2/M arrest, apoptosis, and autophagy via p38 MAPK- and PI3K/Akt/mTOR-mediated pathways in human tongue squamous cell carcinoma cells

Pan ST, Qin Y, Zhou ZW, He ZX, Zhang X, Yang T, Yang YX, Wang D, Qiu JX, Zhou SF

Drug Design, Development and Therapy 2015, 9:1601-1626

Published Date: 16 March 2015

The application of click chemistry in the synthesis of agents with anticancer activity

Ma N, Wang Y, Zhao BX, Ye WC, Jiang S

Drug Design, Development and Therapy 2015, 9:1585-1599

Published Date: 12 March 2015

Induction of apoptosis and autophagy via sirtuin1- and PI3K/Akt/mTOR-mediated pathways by plumbagin in human prostate cancer cells

Zhou ZW, Li XX, He ZX, Pan ST, Yang Y, Zhang X, Chow K, Yang T, Qiu JX, Zhou Q, Tan J, Wang D, Zhou SF

Drug Design, Development and Therapy 2015, 9:1511-1554

Published Date: 12 March 2015

Effect of a topical copper indomethacin gel on inflammatory parameters in a rat model of osteoarthritis

Yassin NZ, El-Shenawy SM, Abdel-Rahman RF, Yakoot M, Hassan M, Helmy S

Drug Design, Development and Therapy 2015, 9:1491-1498

Published Date: 12 March 2015

Positive effects on hematological and biochemical imbalances in patients with metastatic breast cancer stage IV, of BP-C1, a new anticancer substance

Lindkær-Jensen S, Larsen S, Habib-Lindkær-Jensen N, Fagertun HE

Drug Design, Development and Therapy 2015, 9:1481-1490

Published Date: 13 March 2015

Neuroprotective therapies for glaucoma

Song W, Huang P, Zhang C

Drug Design, Development and Therapy 2015, 9:1469-1479

Published Date: 11 March 2015

Design, synthesis, and antifungal activities of novel triazole derivatives containing the benzyl group

Xu K, Huang L, Xu Z, Wang Y, Bai G, Wu Q, Wang X, Yu S, Jiang Y

Drug Design, Development and Therapy 2015, 9:1459-1467

Published Date: 11 March 2015

Cryo-ablation improves anti-tumor immunity through recovering tumor educated dendritic cells in tumor-draining lymph nodes

He XZ, Wang QF, Han S, Wang HQ, Ye YY, Zhu ZY, Zhang SZ

Drug Design, Development and Therapy 2015, 9:1449-1458

Published Date: 10 March 2015

Improved corneal bioavailability of ofloxacin: biodegradable microsphere-loaded ion-activated in situ gel delivery system

Sayed EG, Hussein AK, Khaled KA, Ahmed OAA

Drug Design, Development and Therapy 2015, 9:1427-1435

Published Date: 10 March 2015

Single dose pharmacokinetics of the novel transdermal donepezil patch in healthy volunteers

Kim YH, Choi HY, Lim HS, Lee SH, Jeon HS, Hong D, Kim SS, Choi YK, Bae KS

Drug Design, Development and Therapy 2015, 9:1419-1426

Published Date: 10 March 2015

In vivo antitumor and antimetastatic effects of flavokawain B in 4T1 breast cancer cell-challenged mice

Abu N, Mohamad NE, Yeap SK, Lim KL, Akhtar MN, Zulfadli AJ, Beh BK, Abdullah MP, Omar AR, Alitheen NB

Drug Design, Development and Therapy 2015, 9:1401-1417

Published Date: 6 March 2015

Development and optimization of carvedilol orodispersible tablets: enhancement of pharmacokinetic parameters in rabbits

Aljimaee YH, El-Helw AM, Ahmed OA, El-Say KM

Drug Design, Development and Therapy 2015, 9:1379-1392

Published Date: 5 March 2015

Evaluation of cationic polyamidoamine dendrimers’ dermal toxicity in the rat skin model

Winnicka K, Wroblewska M, Sosnowska K, Car H, Kasacka I

Drug Design, Development and Therapy 2015, 9:1367-1377

Published Date: 5 March 2015

Development and in vitro characterization of drug delivery system of rifapentine for osteoarticular tuberculosis

Wu J, Zuo Y, Hu YJ, Wang J, Li JD, Qiao B, Jiang DM

Drug Design, Development and Therapy 2015, 9:1359-1366

Published Date: 5 March 2015

Clinicopathological significance of CXCR4 in non-small cell lung cancer

Zhou X, He L, Hou G, Jiang B, Wang Y, Zhao L

Drug Design, Development and Therapy 2015, 9:1349-1358

Published Date: 5 March 2015

The effect of ethanol sclerotherapy of 5 minutes duration on cyst diameter and rat ovarian tissue in simple ovarian cysts

Şimşek M, Kuloğlu T, Pala Ş, Boztosun A, Can B, Atilgan R

Drug Design, Development and Therapy 2015, 9:1341-1347

Published Date: 5 March 2015

Profile of atacicept and its potential in the treatment of systemic lupus erythematosus

Cogollo E, Silva MA, Isenberg D

Drug Design, Development and Therapy 2015, 9:1331-1339

Published Date: 5 March 2015

Antitumor activity of SA12, a novel peptide, on SKBr-3 breast cancer cells via the mitochondrial apoptosis pathway

Yang L, Cui Y, Shen J, Lin F, Wang X, Long M, Wei J, Zhang H

Drug Design, Development and Therapy 2015, 9:1319-1330

Published Date: 2 March 2015

In vitro and in vivo anti-angiogenic activity of girinimbine isolated from Murraya koenigii

Iman V, Karimian H, Mohan S, Hobani YH, Noordin MI, Mustafa MR, Noor SM

Drug Design, Development and Therapy 2015, 9:1281-1292

Published Date: 3 March 2015

Antitumoral materials with regenerative function obtained using a layer-by-layer technique

Ficai D, Sonmez M, Albu MG, Mihaiescu DE, Ficai A, Bleotu C

Drug Design, Development and Therapy 2015, 9:1269-1279

Published Date: 2 March 2015

Noncoding RNAs as potential biomarkers to predict the outcome in pancreatic cancer

Jin K, Luo G, Xiao Z, Liu Z, Liu C, Ji S, Xu J, Liu L, Long J, Ni Q, Yu X

Drug Design, Development and Therapy 2015, 9:1247-1255

Published Date: 26 February 2015

Pharmacokinetic-pharmacodynamic analysis to evaluate the effect of moxifloxacin on QT interval prolongation in healthy Korean male subjects

Hong T, Han S, Lee J, Jeon S, Park GJ, Park WS, Lim KS, Chung JY, Yu KS, Yim DS

Drug Design, Development and Therapy 2015, 9:1233-1245

Published Date: 26 February 2015

Advantageous effects of immunosuppression with tacrolimus in comparison with cyclosporine A regarding renal function in patients after heart transplantation

Helmschrott M, Rivinius R, Ruhparwar A, Schmack B, Erbel C, Gleissner CA, Akhavanpoor M, Frankenstein L, Ehlermann P, Bruckner T, Katus HA, Doesch AO

Drug Design, Development and Therapy 2015, 9:1217-1224

Published Date: 24 February 2015

Pharmacokinetic interaction between udenafil and dapoxetine: a randomized, open-labeled crossover study in healthy male volunteers

Kim YH, Choi HY, Lee SH, Jeon HS, Lim HS, Bahng MY, Bae KS

Drug Design, Development and Therapy 2015, 9:1209-1216

Published Date: 23 February 2015

Koenimbin, a natural dietary compound of Murraya koenigii (L) Spreng: inhibition of MCF7 breast cancer cells and targeting of derived MCF7 breast cancer stem cells (CD44+/CD24-/low): an in vitro study

Ahmadipour F, Noordin MI, Mohan S, Arya A, Paydar M, Looi CY, Keong YS, Siyamak EN, Fani S, Firoozi M, Yong CL, Sukari MA, Kamalidehghan B

Drug Design, Development and Therapy 2015, 9:1193-1208

Published Date: 24 February 2015

The pan-inhibitor of Aurora kinases danusertib induces apoptosis and autophagy and suppresses epithelial-to-mesenchymal transition in human breast cancer cells

Li JP, Yang YX, Liu QL, Zhou ZW, Pan ST, He ZX, Zhang X, Yang T, Pan SY, Duan W, He SM, Chen XW, Qiu JX, Zhou SF

Drug Design, Development and Therapy 2015, 9:1027-1062

Published Date: 17 February 2015

Bardoxolone methyl induces apoptosis and autophagy and inhibits epithelial-to-mesenchymal transition and stemness in esophageal squamous cancer cells

Wang YY, Yang YX, Zhao R, Pan ST, Zhe H, He ZX, Duan W, Zhang X, Yang TX, Qiu JX, Zhou SF

Drug Design, Development and Therapy 2015, 9:993-1026

Published Date: 17 February 2015

Synthesis of an anthraquinone derivative (DHAQC) and its effect on induction of G2/M arrest and apoptosis in breast cancer MCF-7 cell line

Yeap SK, Akhtar MN, Lim KL, Abu N, Ho WY, Zareen S, Roohani K, Ky H, Tan SW, Lajis N, Alitheen NB

Drug Design, Development and Therapy 2015, 9:983-992

Published Date: 17 February 2015

1-1-12 one-step wash-in scheme for desflurane low flow anesthesia: performance without nitrous oxide

Sathitkarnmanee T, Tribuddharat S, Nonlhaopol D, Thananun M, Somdee W

Drug Design, Development and Therapy 2015, 9:977-981

Published Date: 17 February 2015

Human mesenchymal stem cells as delivery of osteoprotegerin gene: homing and therapeutic effect for osteosarcoma

Qiao B, Shui W, Cai L, Guo SQ, Jiang DM

Drug Design, Development and Therapy 2015, 9:969-976

Published Date: 17 February 2015

Design, synthesis, and computational studies on dihydropyrimidine scaffolds as potential lipoxygenase inhibitors and cancer chemopreventive agents

Venugopala KN, Govender R, Khedr MA, Venugopala R, Aldhubiab BE, Harsha S, Odhav B

Drug Design, Development and Therapy 2015, 9:911-921

Published Date: 17 February 2015

Upregulation of PD-L1 and APE1 is associated with tumorigenesis and poor prognosis of gastric cancer

Qing Y, Li Q, Ren T, Xia W, Peng Y, Liu GL, Luo H, Yang YX, Dai XY, Zhou SF, Wang D

Drug Design, Development and Therapy 2015, 9:901-909

Published Date: 16 February 2015

Treatment with a herbal formula B401 enhances neuroprotection and angiogenesis in the R6/2 mouse model of Huntington’s disease

Wang SE, Lin CL, Hsu CH, Sheu SJ, Chien CT, Wu CH

Drug Design, Development and Therapy 2015, 9:887-900

Published Date: 16 February 2015

Tazarotene as alternative topical treatment for onychomycosis

Campione E, Paternò EJ, Costanza G, Diluvio L, Carboni I, Marino D, Favalli C, Chimenti S, Bianchi L, Orlandi A

Drug Design, Development and Therapy 2015, 9:879-886

Published Date: 16 February 2015

Anesthetic drug midazolam inhibits cardiac human ether-à-go-go-related gene channels: mode of action

Vonderlin N, Fischer F, Zitron E, Seyler C, Scherer D, Thomas D, Katus HA, Scholz EP,

Drug Design, Development and Therapy 2015, 9:867-877

Published Date: 16 February 2015

Recent advances in combinatorial biosynthesis for drug discovery

Sun H, Liu Z, Zhao H, Ang EL

Drug Design, Development and Therapy 2015, 9:823-833

Published Date: 12 February 2015

Development of a test for recording both visual and auditory reaction times, potentially useful for future studies in patients on opioids therapy

Miceli L, Bednarova R, Rizzardo A, Samogin V, Della Rocca G

Drug Design, Development and Therapy 2015, 9:817-822

Published Date: 12 February 2015

Borreliacidal activity of Borrelia metal transporter A (BmtA) binding small molecules by manganese transport inhibition

Wagh D, Pothineni VR, Inayathullah M, Liu S, Kim KM, Rajadas J

Drug Design, Development and Therapy 2015, 9:805-816

Published Date: 10 February 2015

Clinical utility of eslicarbazepine: current evidence

Zaccara G, Giovannelli F, Cincotta M, Carelli A, Verrotti A

Drug Design, Development and Therapy 2015, 9:781-789

Published Date: 10 February 2015

The role of dasatinib in the management of chronic myeloid leukemia

Chen R, Chen B

Drug Design, Development and Therapy 2015, 9:773-779

Published Date: 9 February 2015

Effect and mechanism of fluoxetine on electrophysiology in vivo in a rat model of postmyocardial infarction depression

Liang J, Yuan X, Shi S, Wang F, Chen Y, Qu C, Chen J, Hu D, Yang B

Drug Design, Development and Therapy 2015, 9:763-772

Published Date: 10 February 2015

Clinical pharmacokinetics of AZD3199, an inhaled ultra-long-acting β2-adrenoreceptor agonist (uLABA)

Bjermer L, Kuna P, Jorup C, Bengtsson T, Rosenborg J

Drug Design, Development and Therapy 2015, 9:753-762

Published Date: 5 February 2015

A pharmacokinetic and pharmacodynamic drug interaction between rosuvastatin and valsartan in healthy subjects

Jung JA, Lee SY, Kim JR, Ko JW, Jang SB, Nam SY, Huh W

Drug Design, Development and Therapy 2015, 9:745-752

Published Date: 2 March 2015

Urine metabolomics in rats after administration of ketamine

Wen C, Zhang M, Ma J, Hu L, Wang X, Lin G

Drug Design, Development and Therapy 2015, 9:717-722

Published Date: 3 February 2015

Steroid for epidural injection in spinal stenosis: a systematic review and meta-analysis

Liu K, Liu PC, Liu R, Wu X, Cai M

Drug Design, Development and Therapy 2015, 9:707-716

Published Date: 30 January 2015

Design and in vivo evaluation of oxycodone once-a-day controlled-release tablets

Kim JY, Lee SH, Park CW, Rhee YS, Kim DW, Park J, Lee M, Seo JW, Park ES

Drug Design, Development and Therapy 2015, 9:695-706

Published Date: 30 January 2015

Profile of delamanid for the treatment of multidrug-resistant tuberculosis

Szumowski JD, Lynch JB

Drug Design, Development and Therapy 2015, 9:677-682

Published Date: 29 January 2015

Apparent histological changes of adipocytes after treatment with CL 316,243, a ß-3-adrenergic receptor agonist

Ghorbani M, Teimourian S, Farzad R, Asl NN

Drug Design, Development and Therapy 2015, 9:669-676

Published Date: 11 February 2015

Antiaging therapy: a prospective hypothesis

Shahidi Bonjar MR, Shahidi Bonjar L

Drug Design, Development and Therapy 2015, 9:663-667

Published Date: 28 January 2015

Organic anion transporter 3- and organic anion transporting polypeptides 1B1- and 1B3-mediated transport of catalposide

Jeong HU, Kwon M, Lee Y, Yoo JS, Shin DH, Song IS, Lee HS

Drug Design, Development and Therapy 2015, 9:643-653

Published Date: 22 January 2015

Development of intramammary delivery systems containing lasalocid for the treatment of bovine mastitis: impact of solubility improvement on safety, efficacy, and milk distribution in dairy cattle

Wang W, Song Y, Petrovski K, Eats P, Trott DJ, Wong HS, Page SW, Perry J, Garg S

Drug Design, Development and Therapy 2015, 9:631-642

Published Date: 22 January 2015

Alisertib induces cell cycle arrest and autophagy and suppresses epithelial-to-mesenchymal transition involving PI3K/Akt/mTOR and sirtuin 1-mediated signaling pathways in human pancreatic cancer cells

Wang F, Li H, Yan XG, Zhou ZW, Yi ZG, He ZX, Pan ST, Yang YX, Wang ZZ, Zhang X, Yang T, Qiu JX, Zhou SF

Drug Design, Development and Therapy 2015, 9:575-601

Published Date: 17 January 2015

Combination therapy of ursodeoxycholic acid and budesonide for PBC–AIH overlap syndrome: a meta-analysis

Zhang H, Yang J, Zhu R, Zheng Y, Zhou Y, Dai W, Wang F, Chen K, Li J, Wang C, Li S, Liu T, Abudumijiti H, Zhou Z, Wang J, Lu W, Wang J, Xia Y, Zhou Y, Lu J, Guo C

Drug Design, Development and Therapy 2015, 9:567-574

Published Date: 17 January 2015

Plumbagin induces cell cycle arrest and autophagy and suppresses epithelial to mesenchymal transition involving PI3K/Akt/mTOR-mediated pathway in human pancreatic cancer cells

Wang F, Wang Q, Zhou ZW, Yu SN, Pan ST, He ZX, Zhang X, Wang D, Yang YX, Yang T, Sun T, Li M, Qiu JX, Zhou SF

Drug Design, Development and Therapy 2015, 9:537-560

Published Date: 17 January 2015

Rare sugar D-psicose prevents progression and development of diabetes in T2DM model Otsuka Long-Evans Tokushima Fatty rats

Hossain A, Yamaguchi F, Hirose K, Matsunaga T, Sui L, Hirata Y, Noguchi C, Katagi A, Kamitori K, Dong Y, Tsukamoto I, Tokuda M

Drug Design, Development and Therapy 2015, 9:525-535

Published Date: 17 January 2015

HMG-CoA reductase inhibitory activity and phytocomponent investigation of Basella alba leaf extract as a treatment for hypercholesterolemia

Baskaran G, Salvamani S, Ahmad SA, Shaharuddin NA, Pattiram PD, Shukor MY

Drug Design, Development and Therapy 2015, 9:509-517

Published Date: 14 January 2015

Inhibition of mitotic Aurora kinase A by alisertib induces apoptosis and autophagy of human gastric cancer AGS and NCI-N78 cells

Yuan CX, Zhou ZW, Yang YX, He ZX, Zhang X, Wang D, Yang T, Wang NJ, Zhao RJ, Zhou SF

Drug Design, Development and Therapy 2015, 9:487-508

Published Date: 14 January 2015

Alisertib, an Aurora kinase A inhibitor, induces apoptosis and autophagy but inhibits epithelial to mesenchymal transition in human epithelial ovarian cancer cells

Ding YH, Zhou ZW, Ha CF, Zhang XY, Pan ST, He ZX, Edelman JL, Wang D, Yang ZX, Zhang XJ, Duan W, Yang TX, Qiu JX, Zhou SF

Drug Design, Development and Therapy 2015, 9:425-464

Published Date: 9 January 2015

Solid lipid nanoparticles loaded with iron to overcome barriers for treatment of iron deficiency anemia

Hosny KM, Banjar ZM, Hariri AH, Hassan AH

Drug Design, Development and Therapy 2015, 9:313-320

Published Date: 8 January 2015

Sample sizes in dosage investigational clinical trials: a systematic evaluation

Huang JH, Su QM, Yang J, Lv YH, He YC, Chen JC, Xu L, Wang K, Zheng QS

Drug Design, Development and Therapy 2015, 9:305-312

Published Date: 7 January 2015

Vipegitide: a folded peptidomimetic partial antagonist of α2β1 integrin with antiplatelet aggregation activity

Momic T, Katzhendler J, Shai E, Noy E, Senderowitz H, Eble JA, Marcinkiewicz C, Varon D, Lazarovici P

Drug Design, Development and Therapy 2015, 9:291-304

Published Date: 5 January 2015

Nanoparticle formulation by Büchi B-90 Nano Spray Dryer for oral mucoadhesion

Harsha SN, Aldhubiab BE, Nair AB, Alhaider IA, Attimarad M, Venugopala KN, Srinivasan S, Gangadhar N, Asif AH

Drug Design, Development and Therapy 2015, 9:273-282

Published Date: 23 January 2015

Synthesis and characterization of a novel chemically designed (Globo)3–DTPA–KLH antigen

Hajmohammadi M, Siadat SD, Ghorbani M, Shafiee Ardestani M, Teimourian S, Asgari V, Ahangari Cohan R, Hajmohammadi M, Hajmohammadi A, Behzadi R, Rajabnezhad S, Namvar Asl N

Drug Design, Development and Therapy 2015, 9:217-239

Published Date: 22 December 2014

Clinicopathological significance and potential drug target of T-cadherin in NSCLC

Wang Z, Wang B, Guo H, Shi G, Hong X

Drug Design, Development and Therapy 2015, 9:207-216

Published Date: 19 December 2014

A thorough QT study in the context of an uptitration regimen with selexipag, a selective oral prostacyclin receptor agonist

Hoch M, Darpo B, Remenova T, Stoltz R, Zhou M, Kaufmann P, Bruderer S, Dingemanse J

Drug Design, Development and Therapy 2015, 9:175-185

Published Date: 17 December 2014

Clinical effect of a positive surgical margin after hepatectomy on survival of patients with intrahepatic cholangiocarcinoma

Yeh CN, Hsieh FJ, Chiang KC, Chen JS, Yeh TS, Jan YY, Chen MF

Drug Design, Development and Therapy 2015, 9:163-174

Published Date: 17 December 2014

Analysis of malignancies in patients after heart transplantation with subsequent immunosuppressive therapy

Rivinius R, Helmschrott M, Ruhparwar A, Schmack B, Klein B, Erbel C, Gleissner CA, Akhavanpoor M, Frankenstein L, Darche FF, Thomas D, Ehlermann P, Bruckner T, Katus HA, Doesch AO

Drug Design, Development and Therapy 2015, 9:93-102

Published Date: 17 December 2014

An evidence-based update on the pharmacological activities and possible molecular targets of Lycium barbarum polysaccharides

Cheng J, Zhou ZW, Sheng HP, He LJ, Fan XW, He ZX, Sun T, Zhang X, Zhao RJ, Gu L, Cao CH, Zhou SF

Drug Design, Development and Therapy 2015, 9:33-78

Published Date: 17 December 2014

Microemulsion of babassu oil as a natural product to improve human immune system function

Pessoa RS, França EL, Ribeiro EB, Lanes PK, Chaud NG, Moraes LC, Honorio-França AC

Drug Design, Development and Therapy 2015, 9:21-31

Published Date: 16 December 2014

Xyloketal B, a marine compound, acts on a network of molecular proteins and regulates the activity and expression of rat cytochrome P450 3a: a bioinformatic and animal study

Su JH, Chang C, Xiang Q, Zhou ZW, Luo R, Yang L, He ZX, Yang HT, Li J, Bei Y, Xu JM, Zhang MJ, Zhang QH, Su ZJ, Huang YD, Pang JY, Zhou SF

Drug Design, Development and Therapy 2014, 8:2555-2602

Published Date: 12 December 2014

Curative treatment can be an option for patients with metastatic squamous cell cancer of the head and neck

Guenne C, Fayette J, Cosmidis A, Fuchsmann C, Tartas S, Favrel V, Céruse P

Drug Design, Development and Therapy 2014, 8:2549-2553

Published Date: 12 December 2014

Stevens–Johnson Syndrome and toxic epidermalnecrolysis: a multi-aspect comparative 7-year study from the People’s Republic of China

Sun J, Liu J, Gong QL, Ding GZ, Ma LW, Zhang LC, Lu Y

Drug Design, Development and Therapy 2014, 8:2539-2547

Published Date: 12 December 2014

Treatment of port wine stains with pulsed dye laser: a retrospective study of 848 cases in Shandong Province, People’s Republic of China

Shi W, Wang J, Lin Y, Geng J, Wang H, Gong Y, Liu H, Zhang F

Drug Design, Development and Therapy 2014, 8:2531-2538

Published Date: 12 December 2014

Sequential treatment with AT-101 enhances cisplatin chemosensitivity in human non-small cell lung cancer cells through inhibition of apurinic/apyrimidinic endonuclease 1-activated IL-6/STAT3 signaling pathway

Ren T, Shan J, Qing Y, Qian C, Li Q, Lu G, Li M, Li C, Peng Y, Luo H, Zhang S, Zhang W, Wang D, Zhou SF

Drug Design, Development and Therapy 2014, 8:2517-2529

Published Date: 12 December 2014

A new recombinant factor VIII: from genetics to clinical use

Santagostino E

Drug Design, Development and Therapy 2014, 8:2507-2515

Published Date: 12 December 2014

Dapagliflozin for the treatment of type 2 diabetes: a review of the literature

Saeed MA, Narendran P

Drug Design, Development and Therapy 2014, 8:2493-2505

Published Date: 10 December 2014

Scientometrics of anesthetic drugs and their techniques of administration, 1984–2013

Vlassakov KV, Kissin I

Drug Design, Development and Therapy 2014, 8:2463-2473

Published Date: 9 December 2014

Mesenchymal stem cell-based NK4 gene therapy in nude mice bearing gastric cancer xenografts

Zhu Y, Cheng M, Yang Z, Zeng CY, Chen J, Xie Y, Luo SW, Zhang KH, Zhou SF, Lu NH

Drug Design, Development and Therapy 2014, 8:2449-2462

Published Date: 9 December 2014

Matrix-induced autologous chondrocyte implantation for the treatment of chondral defects of the knees in Chinese patients

Zhang ZW, Zhong X, Ji HR, Tang ZB, Bai JP, Yao MM, Hou JL, Zheng MH, Wood D, Sun JZ, Zhou SF, Liu AB

Drug Design, Development and Therapy 2014, 8:2439-2448

Published Date: 5 December 2014

Design real-time reversal of tumor multidrug resistance cleverly with shortened carbon nanotubes

Wu P, Li S, Zhang H

Drug Design, Development and Therapy 2014, 8:2431-2438

Published Date: 5 December 2014

Clinicopathological significance and potential drug target of RUNX3 in breast cancer

Yu YY, Chen C, Kong FF, Zhang W

Drug Design, Development and Therapy 2014, 8:2423-2430

Published Date: 5 December 2014

Cisplatin-induced hyponatremia in malignancy: comparison between brand-name and generic formulation

Ochi N, Yamane H, Hotta K, Fujii H, Isozaki H, Honda Y, Yamagishi T, Kubo T, Tanimoto M, Kiura K, Takigawa N

Drug Design, Development and Therapy 2014, 8:2401-2408

Published Date: 3 December 2014

Drug development strategies for the treatment of obesity: how to ensure efficacy, safety, and sustainable weight loss

Barja-Fernandez S, Leis R, Casanueva FF, Seoane LM

Drug Design, Development and Therapy 2014, 8:2391-2400

Published Date: 1 December 2014

Discovery of potential drugs for human-infecting H7N9 virus containing R294K mutation

He JY, Li C, Wu G

Drug Design, Development and Therapy 2014, 8:2377-2390

Published Date: 1 December 2014

Scleral melt following Retisert intravitreal fluocinolone implant

Georgalas I, Koutsandrea C, Papaconstantinou D, Mpouritis D, Petrou P

Drug Design, Development and Therapy 2014, 8:2373-2375

Published Date: 28 November 2014

CCL19 and CCL21 modulate the inflammatory milieu in atherosclerotic lesions

Akhavanpoor M, Gleissner CA, Gorbatsch S, Doesch AO, Akhavanpoor H, Wangler S, Jahn F, Lasitschka F, Katus HA, Erbel C

Drug Design, Development and Therapy 2014, 8:2359-2371

Published Date: 27 November 2014

Interleukin 1 inhibition with anakinra in adult-onset Still disease: a meta-analysis of its efficacy and safety

Hong D, Yang Z, Han SY, Liang X, Ma K, Zhang X

Drug Design, Development and Therapy 2014, 8:2345-2357

Published Date: 25 November 2014

Characterization and in vitro studies of the anticancer effect of oxidized carbon nanotubes functionalized with betulinic acid

Tan JM, Karthivashan G, Arulselvan P, Fakurazi S, Hussein MZ

Drug Design, Development and Therapy 2014, 8:2333-2343

Published Date: 20 November 2014

Pilot Phase II study of mazindol in children with attention deficit/hyperactivity disorder

Konofal E, Zhao W, Laouénan C, Lecendreux M, Kaguelidou F, Benadjaoud L, Mentré F, Jacqz-Aigrain E

Drug Design, Development and Therapy 2014, 8:2321-2332

Published Date: 11 December 2014

Choosing preclinical study models of diabetic retinopathy: key problems for consideration

Mi XS, Yuan TF, Ding Y, Zhong JX, So KF

Drug Design, Development and Therapy 2014, 8:2311-2319

Published Date: 18 November 2014

Profile of epratuzumab and its potential in the treatment of systemic lupus erythematosus

Al Rayes H, Touma Z

Drug Design, Development and Therapy 2014, 8:2303-2310

Published Date: 17 November 2014

Leptin signaling molecular actions and drug target in hepatocellular carcinoma

Jiang N, Sun R, Sun Q

Drug Design, Development and Therapy 2014, 8:2295-2302

Published Date: 14 November 2014

Risk of diarrhea in patients with type 2 diabetes mellitus treated with sitagliptin: a meta-analysis of 30 randomized clinical trials

Zhao QW, Hong DS, Zheng DS, Xiao Y, Wu BH

Drug Design, Development and Therapy 2014, 8:2283-2294

Published Date: 11 November 2014

The role of health technology assessment bodies in shaping drug development

Ciani O, Jommi C

Drug Design, Development and Therapy 2014, 8:2273-2281

Published Date: 10 November 2014

Inhibition of cardiac Kv1.5 potassium current by the anesthetic midazolam: mode of action

Vonderlin N, Fischer F, Zitron E, Seyler C, Scherer D, Thomas D, Katus HA, Scholz EP

Drug Design, Development and Therapy 2014, 8:2263-2271

Published Date: 7 November 2014

Identification of novel multitargeted PPARα/γ/δ pan agonists by core hopping of rosiglitazone

Wang XJ, Zhang J, Wang SQ, Xu WR, Cheng XC, Wang RL

Drug Design, Development and Therapy 2014, 8:2255-2262

Published Date: 7 November 2014

Women taking the “blue pill” (sildenafil citrate): such a big deal?

Lo Monte G, Graziano A, Piva I, Marci R

Drug Design, Development and Therapy 2014, 8:2251-2254

Published Date: 7 November 2014

Early non-steady-state population pharmacokinetics of oral cyclosporine in renal transplant recipients

Baek H, Han S, Yim DS, Kim SJ, Lee SY, Jang HR, Lee JE, Kim DJ, Kim YG, Oh HY, Huh W

Drug Design, Development and Therapy 2014, 8:2241-2249

Published Date: 7 November 2014

Caval filters in intensive care: a retrospective study

Ferraro F, Di Gennaro TL, Torino A, Petruzzi J, d'Elia A, Fusco P, Marfella R, Lettieri B

Drug Design, Development and Therapy 2014, 8:2213-2219

Published Date: 6 November 2014

Involvement of NF-ΚB and HSP70 signaling pathways in the apoptosis of MDA-MB-231 cells induced by a prenylated xanthone compound, α-mangostin, from Cratoxylum arborescens

Ibrahim MY, Hashim NM, Mohan S, Abdulla MA, Abdelwahab SI, Kamalidehghan B, Ghaderian M, Dehghan F, Ali LZ, Karimian H, Yahayu M, Ee GCL, Farjam AS, Ali HM

Drug Design, Development and Therapy 2014, 8:2193-2211

Published Date: 6 November 2014

The CB1 cannabinoid receptor agonist reduces L-DOPA-induced motor fluctuation and ERK1/2 phosphorylation in 6-OHDA-lesioned rats

Song L, Yang X, Ma Y, Wu N, Liu Z

Drug Design, Development and Therapy 2014, 8:2173-2180

Published Date: 4 November 2014

Discovery and evaluation of novel anti-inflammatory derivatives of natural bioactive curcumin

Zhang Y, Jiang X, Peng K, Chen C, Fu L, Wang Z, Feng J, Liu Z, Zhang H, Liang G, Pan Z

Drug Design, Development and Therapy 2014, 8:2161-2171

Published Date: 4 November 2014

Functional analysis of tanshinone IIA that blocks the redox function of human apurinic/apyrimidinic endonuclease 1/redox factor-1

Sui J, Li M, Qian C, Wang S, Cheng Y, Chen BP, Wang D

Drug Design, Development and Therapy 2014, 8:2147-2160

Published Date: 3 November 2014

Effect of honokiol on the induction of drug-metabolizing enzymes in human hepatocytes

Cho YY, Jeong HU, Kim JH, Lee HS

Drug Design, Development and Therapy 2014, 8:2137-2145

Published Date: 3 November 2014

Clinicopathological significance and potential drug target of p15INK4B in multiple myeloma

Li J, Bi L, Lin Y, Lu Z, Hou G

Drug Design, Development and Therapy 2014, 8:2129-2136

Published Date: 31 October 2014

Curcumin could reduce the monomer of TTR with Tyr114Cys mutation via autophagy in cell model of familial amyloid polyneuropathy

Li H, Zhang Y, Cao L, Xiong R, Zhang B, Wu L, Zhao Z, Chen SD

Drug Design, Development and Therapy 2014, 8:2121-2128

Published Date: 31 October 2014

The influence of goal-directed fluid therapy on the prognosis of elderly patients with hypertension and gastric cancer surgery

Zeng K, Li YZ, Liang M, Gao YG, Cai HD, Lin CZ

Drug Design, Development and Therapy 2014, 8:2113-2119

Published Date: 29 October 2014

Gastroprotective activity of Annona muricata leaves against ethanol-induced gastric injury in rats via Hsp70/Bax involvement

Moghadamtousi SZ, Rouhollahi E, Karimian H, Fadaeinasab M, Abdulla MA, Kadir HA

Drug Design, Development and Therapy 2014, 8:2099-2111

Published Date: 28 October 2014

The role of ketotifen in the prevention of testicular damage in rats with experimental unilateral undescended testes

Acikgoz A, Asci R, Aydin O, Çavuş H, Donmez G, Buyukalpelli R

Drug Design, Development and Therapy 2014, 8:2089-2097

Published Date: 23 October 2014

Bardoxolone methyl (CDDO-Me) as a therapeutic agent: an update on its pharmacokinetic and pharmacodynamic properties

Wang YY, Yang YX, Zhe H, He ZX, Zhou SF

Drug Design, Development and Therapy 2014, 8:2075-2088

Published Date: 23 October 2014

Effects of caffeic acid phenethyl ester on palatal mucosal defects and tooth extraction sockets

Günay A, Arpağ OF, Atilgan S, Yaman F, Atalay Y, Acikan I

Drug Design, Development and Therapy 2014, 8:2069-2074

Published Date: 23 October 2014

Ginger components as new leads for the design and development of novel multi-targeted anti-Alzheimer’s drugs: a computational investigation

Azam F, Amer AM, Abulifa AR, Elzwawi MM

Drug Design, Development and Therapy 2014, 8:2045-2059

Published Date: 23 October 2014

Safety and efficacy of peramivir for influenza treatment

Hata A, Akashi-Ueda R, Takamatsu K, Matsumura T

Drug Design, Development and Therapy 2014, 8:2017-2038

Published Date: 24 October 2014

Immunomodulatory effects of 17-O-acetylacuminolide in RAW264.7 cells and HUVECs: involvement of MAPK and NF-κB pathways

Achoui M, Heyninck K, Looi CY, Mustafa AM, Haegeman G, Mustafa MR

Drug Design, Development and Therapy 2014, 8:1993-2007

Published Date: 20 October 2014

Risk factors associated with ineligibility of adjuvant cisplatin-based chemotherapy after nephroureterectomy

Shao IH, Lin YH, Hou CP, Juang HH, Chen CL, Chang PL, Tsui KH

Drug Design, Development and Therapy 2014, 8:1985-1991

Published Date: 21 October 2014

Anticancer efficacy and absorption, distribution, metabolism, and toxicity studies of Aspergiolide A in early drug development

Wang Y, Qi X, Li D, Zhu T, Mo X, Li J

Drug Design, Development and Therapy 2014, 8:1965-1977

Published Date: 17 October 2014

Intestinal absorption, organ distribution, and urinary excretion of the rare sugar D-psicose

Tsukamoto I, Hossain A, Yamaguchi F, Hirata Y, Dong Y, Kamitori K, Sui L, Nonaka M, Ueno M, Nishimoto K, Suda H, Morimoto K, Shimonishi T, Saito M, Song T, Konishi R, Tokuda M

Drug Design, Development and Therapy 2014, 8:1955-1964

Published Date: 17 October 2014

Indole and synthetic derivative activate chaperone expression to reduce polyQ aggregation in SCA17 neuronal cell and slice culture models

Kung PJ, Tao YC, Hsu HC, Chen WL, Lin TH, Janreddy D, Yao CF, Chang KH, Lin JY, Su MT, Wu CH, Lee-Chen GJ, Hsieh-Li HM

Drug Design, Development and Therapy 2014, 8:1929-1939

Published Date: 16 October 2014

Influence of caffeine and hyaluronic acid on collagen biosynthesis in human skin fibroblasts

Donejko M, Przylipiak A, Rysiak E, Głuszuk K, Surażyński A

Drug Design, Development and Therapy 2014, 8:1923-1928

Published Date: 15 October 2014

Animal models and therapeutic molecular targets of cancer: utility and limitations

Cekanova M, Rathore K

Drug Design, Development and Therapy 2014, 8:1911-1922

Published Date: 14 October 2014

Multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer’s disease: design, synthesis, biochemical evaluation, ADMET, molecular modeling, and QSAR analysis of novel donepezil-pyridyl hybrids

Bautista-Aguilera OM, Esteban G, Chioua M, Nikolic K, Agbaba D, Moraleda I, Iriepa I, Soriano E, Samadi A, Unzeta M, Marco-Contelles J

Drug Design, Development and Therapy 2014, 8:1893-1910

Published Date: 13 October 2014

Synthesis and biological evaluation of novel indole-2-one and 7-aza-2-oxindole derivatives as anti-inflammatory agents

Chen G, Jiang L, Dong L, Wang Z, Xu F, Ding T, Fu L, Fang Q, Liu Z, Shan X, Liang G

Drug Design, Development and Therapy 2014, 8:1869-1892

Published Date: 13 October 2014

Preclinical profile of cabazitaxel

Vrignaud P, Semiond D, Benning V, Beys E, Bouchard H, Gupta S

Drug Design, Development and Therapy 2014, 8:1851-1867

Published Date: 13 October 2014

Potent tumor targeting drug release system comprising MMP-2 specific peptide fragment with self-assembling characteristics

Hua D, Kong W, Zheng X, Zhou Z, Yu B, Li Y, Wang Y, Yang X, Liu C, Tang L, Li Y, Gong M

Drug Design, Development and Therapy 2014, 8:1839-1849

Published Date: 14 October 2014

Effects of an oral allosteric AKT inhibitor (MK-2206) on human nasopharyngeal cancer in vitro and in vivo

Zhao YY, Tian Y, Zhang J, Xu F, Yang YP, Huang Y, Zhao HY, Zhang JW, Xue C, Lam MH, Yan L, Hu ZH, Dinglin XX, Zhang L

Drug Design, Development and Therapy 2014, 8:1827-1837

Published Date: 10 October 2014

Topical pimecrolimus inhibits high-dose UVB irradiation-induced epidermal Langerhans cell migration, via regulation of TNF-a and E-cadherin

Yin Z, Xu J, Zhou B, Wu D, Xu Y, Zhang J, Luo D

Drug Design, Development and Therapy 2014, 8:1817-1825

Published Date: 10 October 2014

Development of polyether urethane intravaginal rings for the sustained delivery of hydroxychloroquine

Chen Y, Traore YL, Li A, Fowke KR, Ho EA

Drug Design, Development and Therapy 2014, 8:1801-1815

Published Date: 9 October 2014

Purification and in vitro antioxidant activities of tellurium-containing phycobiliproteins from tellurium-enriched Spirulina platensis

Yang F, Wong KH, Yang YF, Li XL, Jiang J, Zheng WJ, Wu HL, Chen TF

Drug Design, Development and Therapy 2014, 8:1789-1800

Published Date: 9 October 2014

Evaluation of the pharmacokinetic and pharmacodynamic drug interactions between cilnidipine and valsartan, in healthy volunteers

Lee J, Lee H, Jang K, Lim KS, Shin D, Yu KS

Drug Design, Development and Therapy 2014, 8:1781-1788

Published Date: 8 October 2014

(R)-(+)-α-Lipoic acid protected NG108-15 cells against H2O2-induced cell death through PI3K-Akt/GSK-3β pathway and suppression of NF-κβ-cytokines

Kamarudin MNA, Mohd Raflee NA, Syed Hussein SS, Lo JY, Supriady H, Abdul Kadir H

Drug Design, Development and Therapy 2014, 8:1765-1780

Published Date: 8 October 2014

Inhaled tyrosine kinase inhibitors for pulmonary hypertension: a possible future treatment

Pitsiou G, Zarogoulidis P, Petridis D, Kioumis I, Lampaki S, Organtzis J, Porpodis K, Papaiwannou A, Tsiouda T, Hohenforst-Schmidt W, Kakolyris S, Syrigos K, Huang H, Li Q, Turner JF, Zarogoulidis K

Drug Design, Development and Therapy 2014, 8:1753-1763

Published Date: 7 October 2014

Effect of renal function on the pharmacokinetics of fimasartan: a single-dose, open-label, Phase I study

Kim S, Lee J, Shin D, Lim KS, Kim YS, Jang IJ, Yu KS

Drug Design, Development and Therapy 2014, 8:1723-1731

Published Date: 6 October 2014

Multiple-dose pharmacokinetics and pharmacodynamics of evogliptin (DA-1229), a novel dipeptidyl peptidase IV inhibitor, in healthy volunteers

Gu N, Park MK, Kim TE, Bahng MY, Lim KS, Cho SH, Yoon SH, Cho JY, Jang IJ, Yu KS

Drug Design, Development and Therapy 2014, 8:1709-1721

Published Date: 6 October 2014

Effects of immunosuppressive treatment on protein expression in rat kidney

Kędzierska K, Sporniak-Tutak K, Sindrewicz K, Bober J, Domański L, Parafiniuk M, Urasińska E, Ciechanowicz A, Domański M, Smektała T, Masiuk M, Skrzypczak W, Ożgo M, Kabat-Koperska J, Ciechanowski K,

Drug Design, Development and Therapy 2014, 8:1695-1708

Published Date: 30 September 2014

Exploratory meta-analysis on lisdexamfetamine versus placebo in adult ADHD

Maneeton N, Maneeton B, Suttajit S, Reungyos J, Srisurapanont M, Martin SD

Drug Design, Development and Therapy 2014, 8:1685-1693

Published Date: 3 October 2014

An optimized probucol microencapsulated formulation integrating a secondary bile acid (deoxycholic acid) as a permeation enhancer

Mooranian A, Negrulj R, Chen-Tan N, Watts GF, Arfuso F, Al-Salami H

Drug Design, Development and Therapy 2014, 8:1673-1683

Published Date: 29 September 2014

Anticancer, antioxidant activities, and DNA affinity of novel monocationic bithiophenes and analogues

Ismail MA, Arafa RK, Yousssef MM, El-Sayed WM

Drug Design, Development and Therapy 2014, 8:1659-1672

Published Date: 29 September 2014

Fusion of cell-penetrating peptides to thermally responsive biopolymer improves tumor accumulation of p21 peptide in a mouse model of pancreatic cancer

Walker LR, Ryu JS, Perkins E, McNally LR, Raucher D

Drug Design, Development and Therapy 2014, 8:1649-1658

Published Date: 7 October 2014

α-Mangostin from Cratoxylum arborescens demonstrates apoptogenesis in MCF-7 with regulation of NF-κB and Hsp70 protein modulation in vitro, and tumor reduction in vivo

Ibrahim MY, Hashim NM, Mohan S, Abdulla MA, Kamalidehghan B, Ghaderian M, Dehghan F, Ali LZ, Arbab IA, Yahayu M, Lian GE, Ahmadipour F, Ali HM

Drug Design, Development and Therapy 2014, 8:1629-1647

Published Date: 27 September 2014

Buccal acetaminophen provides fast analgesia: two randomized clinical trials in healthy volunteers

Pickering G, Macian N, Libert F, Cardot JM, Coissard S, Perovitch P, Maury M, Dubray C

Drug Design, Development and Therapy 2014, 8:1621-1627

Published Date: 26 September 2014

Pharmacokinetics and tolerability of the new second-generation nonnucleoside reverse- transcriptase inhibitor KM-023 in healthy subjects

Cha YJ, Lim KS, Park MK, Schneider S, Bray B, Kang MC, Chung JY, Yoon SH, Cho JY, Yu KS

Drug Design, Development and Therapy 2014, 8:1613-1619

Published Date: 26 September 2014

EGFR mutations as a prognostic and predictive marker in non-small-cell lung cancer

Fang S, Wang Z

Drug Design, Development and Therapy 2014, 8:1595-1611

Published Date: 26 September 2014

Bioactive protein fraction DLBS1033 containing lumbrokinase isolated from Lumbricus rubellus: ex vivo, in vivo, and pharmaceutic studies

Tjandrawinata RR, Trisina J, Rahayu P, Prasetya LA, Hanafiah A, Rachmawati H

Drug Design, Development and Therapy 2014, 8:1585-1593

Published Date: 25 September 2014

Phyllostachys edulis extract induces apoptosis signaling in osteosarcoma cells, associated with AMPK activation

Chou CW, Cheng YW, Tsai CH

Drug Design, Development and Therapy 2014, 8:1577-1584

Published Date: 24 September 2014

Provisional in-silico biopharmaceutics classification (BCS) to guide oral drug product development

Wolk O, Agbaria R, Dahan A

Drug Design, Development and Therapy 2014, 8:1563-1575

Published Date: 24 September 2014

Interferon-γ and celecoxib inhibit lung-tumor growth through modulating M2/M1 macrophage ratio in the tumor microenvironment

Ren F, Fan M, Mei J, Wu Y, Liu C, Pu Q, You Z, Liu L

Drug Design, Development and Therapy 2014, 8:1527-1538

Published Date: 23 September 2014

Synthesis and antibacterial activities of acylide derivatives bearing an aryl-tetrazolyl chain

Shan LX, Sun PH, Guo BQ, Xu XJ, Li ZQ, Sun JZ, Zhou SF, Chen WM

Drug Design, Development and Therapy 2014, 8:1515-1525

Published Date: 24 September 2014

Drug-likeness approach of 2-aminopyrimidines as histamine H3 receptor ligands

Sadek B, Schreeb A, Schwed JS, Weizel L, Stark H

Drug Design, Development and Therapy 2014, 8:1499-1513

Published Date: 19 September 2014

Ferulago angulata activates intrinsic pathway of apoptosis in MCF-7 cells associated with G1 cell cycle arrest via involvement of p21/p27

Karimian H, Moghadamtousi SZ, Fadaeinasab M, Golbabapour S, Razavi M, Hajrezaie M, Arya A, Abdulla MA, Mohan S, Ali HM, Noordin MI

Drug Design, Development and Therapy 2014, 8:1481-1497

Published Date: 22 September 2014

Enhanced bioavailability and anthelmintic efficacy of mebendazole in redispersible microparticles with low-substituted hydroxypropylcellulose

Torre-Iglesias PM, García-Rodriguez JJ, Torrado G, Torrado S, Torrado-Santiago S, Bolás-Fernández F

Drug Design, Development and Therapy 2014, 8:1467-1479

Published Date: 18 September 2014

Pemphigus erythematosus relapse associated with atorvastatin intake

Lo Schiavo A, Puca RV, Romano F, Cozzi R

Drug Design, Development and Therapy 2014, 8:1463-1465

Published Date: 18 September 2014

Defensive mechanism in cholangiocarcinoma cells against oxidative stress induced by chlorin e6-based photodynamic therapy

Lee HM, Chung CW, Kim CH, Kim DH, Kwak TW, Jeong YI, Kang DH

Drug Design, Development and Therapy 2014, 8:1451-1462

Published Date: 18 September 2014

Comparison of dexamethasone intravitreal implant and intravitreal triamcinolone acetonide for the treatment of pseudophakic cystoid macular edema in diabetic patients

Dang Y, Mu Y, Li L, Mu Y, Liu S, Zhang C, Zhu Y, Xu Y

Drug Design, Development and Therapy 2014, 8:1441-1449

Published Date: 18 September 2014

Time and dose relationships between schisandrin B- and schisandrae fructus oil-induced hepatotoxicity and the associated elevations in hepatic and serum triglyceride levels in mice

Zhang Y, Pan SY, Zhou SF, Wang XY, Sun N, Zhu PL, Chu ZS, Yu ZL, Ko KM

Drug Design, Development and Therapy 2014, 8:1429-1439

Published Date: 19 September 2014

Naltrexone sustained-release/bupropion sustained-release for the management of obesity: review of the data to date

Caixàs A, Albert L, Capel I, Rigla M

Drug Design, Development and Therapy 2014, 8:1419-1427

Published Date: 18 September 2014

Inhibition of urokinase plasminogen activator “uPA” activity alters ethanol consumption and conditioned place preference in mice

Al Maamari E, Al Ameri M, Al Mansouri S, Bahi A

Drug Design, Development and Therapy 2014, 8:1391-1403

Published Date: 16 September 2014

Update on developments with SGLT2 inhibitors in the management of type 2 diabetes

Nauck MA

Drug Design, Development and Therapy 2014, 8:1335-1380

Published Date: 11 September 2014

Aminaphtone in the control of gingival bleeding in children

Pereira de Godoy JM, Macedo Paizan ML

Drug Design, Development and Therapy 2014, 8:1331-1334

Published Date: 10 September 2014

Novel swellable polymer of orchidaceae family for gastroretentive drug delivery of famotidine

Razavi M, Nyamathulla S, Karimian H, Noordin MI

Drug Design, Development and Therapy 2014, 8:1315-1329

Published Date: 9 September 2014

Superior rejection profile during the first 24 months after heart transplantation under tacrolimus as baseline immunosuppressive regimen

Helmschrott M, Beckendorf J, Akyol C, Ruhparwar A, Schmack B, Erbel C, Gleissner CA, Akhavanpoor M, Ehlermann P, Bruckner T, Katus HA, Doesch AO

Drug Design, Development and Therapy 2014, 8:1307-1314

Published Date: 9 September 2014

Efficacy and safety of immunosuppressive therapy in the treatment of seronegative hepatitis associated aplastic anemia

Chen HF, Xu BX, Shen HS, Li ZY, Jin LJ, Tang JQ, Wang J, Zhu JJ, Qin LM, Cui QY, Ren YY, Wu TQ

Drug Design, Development and Therapy 2014, 8:1299-1305

Published Date: 9 September 2014

Synthesis and characterization of a glycine- modified heptamethine indocyanine dye for in vivo cancer-targeted near-infrared imaging

Liu T, Luo S, Wang Y, Tan X, Qi Q, Shi C

Drug Design, Development and Therapy 2014, 8:1287-1297

Published Date: 9 September 2014

Hydrogen sulfide, a potential novel drug, attenuates concanavalin A-induced hepatitis

Cheng P, Chen K, Xia Y, Dai WQ, Wang F, Shen M, Wang C, Yang J, Zhu R, Zhang H, Li JJ, Zheng Y, Wang J, Zhang Y, Lu J, Zhou YQ, Guo CY

Drug Design, Development and Therapy 2014, 8:1277-1286

Published Date: 9 September 2014

Update on the clinical utility and practical use of ropivacaine in Chinese patients

Li M, Wan L, Mei W, Tian Y

Drug Design, Development and Therapy 2014, 8:1269-1276

Published Date: 9 September 2014

N-n-butyl haloperidol iodide inhibits H2O2- induced Na+/Ca2+-exchanger activation via the Na+/H+ exchanger in rat ventricular myocytes

Huang YP, Gao FF, Wang B, Zheng FC, Zhang YM, Chen YC, Huang ZQ, Zheng YS, Zhong SP, Shi GG

Drug Design, Development and Therapy 2014, 8:1257-1267

Published Date: 9 September 2014

Single dose pharmacokinetic equivalence study of two gabapentin preparations in healthy subjects

Tjandrawinata RR, Setiawati E, Putri RSI, Yunaidi DA, Amalia F, Susanto LW

Drug Design, Development and Therapy 2014, 8:1249-1255

Published Date: 4 September 2014

Characterization and evaluation of amine-modified graphene amphotericin B for the treatment of visceral leishmaniasis: in vivo and in vitro studies

Mudavath SL, Talat M, Rai M, Srivastava ON, Sundar S

Drug Design, Development and Therapy 2014, 8:1235-1247

Published Date: 4 September 2014

Transient hypofibrinogenemia due to allopurinol

Yin ZQ, Xu JL, Li YQ, Xia JP, Luo D

Drug Design, Development and Therapy 2014, 8:1231-1233

Published Date: 2 September 2014

Microencapsulation as a novel delivery method for the potential antidiabetic drug, Probucol

Mooranian A, Negrulj R, Chen-Tan N, Al-Sallami HS, Fang Z, Mukkur TK, Mikov M, Golocorbin-Kon S, Fakhoury M, Watts GF, Matthews V, Arfuso F, Al-Salami H

Drug Design, Development and Therapy 2014, 8:1221-1230

Published Date: 9 September 2014

Combination therapy with sivelestat and recombinant human soluble thrombomodulin for ARDS and DIC patients

Miyoshi S, Ito R, Katayama H, Dote K, Aibiki M, Hamada H, Okura T, Higaki J

Drug Design, Development and Therapy 2014, 8:1211-1219

Published Date: 2 September 2014

Update on the clinical utility of once-daily tacrolimus in the management of transplantation

Posadas Salas MA, Srinivas TR

Drug Design, Development and Therapy 2014, 8:1183-1194

Published Date: 1 September 2014

Remote ischemic conditioning improves coronary microcirculation in healthy subjects and patients with heart failure

Kono Y, Fukuda S, Hanatani A, Nakanishi K, Otsuka K, Taguchi H, Shimada K

Drug Design, Development and Therapy 2014, 8:1175-1181

Published Date: 27 August 2014

The efficacy of ampicillin and Lactobacillus casei rhamnosus in the active management of preterm premature rupture of membranes remote from term

Kavak SB, Kavak E, Ilhan R, Atilgan R, Arat O, Deveci U, Sapmaz E

Drug Design, Development and Therapy 2014, 8:1169-1173

Published Date: 30 August 2014

Effect of administration of water enriched in O2 by injection or electrolysis on transcutaneous oxygen pressure in anesthetized pigs

Charton A, Péronnet F, Doutreleau S, Lonsdorfer E, Klein A, Jimenez L, Geny B, Diemunsch P, Richard R

Drug Design, Development and Therapy 2014, 8:1161-1167

Published Date: 26 August 2014

Downregulated microRNA-148b in circulating PBMCs in chronic myeloid leukemia patients with undetectable minimal residual disease: a possible biomarker to discontinue imatinib safely

Ohyashiki JH, Ohtsuki K, Mizoguchi I, Yoshimoto T, Katagiri S, Umezu T, Ohyashiki K

Drug Design, Development and Therapy 2014, 8:1151-1159

Published Date: 25 August 2014

Design of an epitope-based peptide vaccine against spike protein of human coronavirus: an in silico approach

Oany AR, Emran AA, Jyoti TP

Drug Design, Development and Therapy 2014, 8:1139-1149

Published Date: 21 August 2014

Nasal saline as a placebo in a rhinosinusitis study

Karadag A, Catal F

Drug Design, Development and Therapy 2014, 8:1135-1137

Published Date: 20 August 2014

Comparison of effects of anti-angiogenic agents in the zebrafish efficacy–toxicity model for translational anti-angiogenic drug discovery

Chimote G, Sreenivasan J, Pawar N, Subramanian J, Sivaramakrishnan H, Sharma S

Drug Design, Development and Therapy 2014, 8:1107-1123

Published Date: 19 August 2014

Predictive performance of gentamicin dosing nomograms

Lee J, Yoon S, Shin D, Han H, An H, Lee J, Lim KS, Yu KS, Lee H

Drug Design, Development and Therapy 2014, 8:1097-1106

Published Date: 16 August 2014

Investigation of aromatase inhibitory activity of metal complexes of 8-hydroxyquinoline and uracil derivatives

Prachayasittikul V, Pingaew R, Nantasenamat C, Prachayasittikul S, Ruchirawat S, Prachayasittikul V

Drug Design, Development and Therapy 2014, 8:1089-1096

Published Date: 14 August 2014

Safety and efficacy of S-1 chemotherapy in recurrent and metastatic nasopharyngeal carcinoma patients after failure of platinum-based chemotherapy: multi-institutional retrospective analysis

Peng PJ, Cheng H, Ou XQ, Zeng LJ, Wu X, Liu YM, Lin Z, Tang YN, Wang SY, Zhang HY, Chen ZB

Drug Design, Development and Therapy 2014, 8:1083-1087

Published Date: 14 August 2014

Meclofenamate elicits a nephropreventing effect in a rat model of ischemic acute kidney injury by suppressing indoxyl sulfate production and restoring renal organic anion transporters

Saigo C, Nomura Y, Yamamoto Y, Sagata M, Matsunaga R, Jono H, Nishi K, Saito H

Drug Design, Development and Therapy 2014, 8:1073-1082

Published Date: 13 August 2014

Optimization of nebulized delivery of linezolid, daptomycin, and vancomycin aerosol

Zarogoulidis P, Kioumis I, Lampaki S, Organtzis J, Porpodis K, Spyratos D, Pitsiou G, Petridis D, Pataka A, Huang H, Li Q, Yarmus L, Hohenforst-Schmidt W, Pezirkianidis N, Zarogoulidis K

Drug Design, Development and Therapy 2014, 8:1065-1072

Published Date: 12 August 2014

Efficacy of the small molecule inhibitor of Lipid II BAS00127538 against Acinetobacter baumannii

de Leeuw EPH

Drug Design, Development and Therapy 2014, 8:1061-1064

Published Date: 8 August 2014

Design, synthesis, and anticancer activity of novel berberine derivatives prepared via CuAAC “click” chemistry as potential anticancer agents

Jin X, Yan TH, Yan L, Li Q, Wang RL, Hu ZL, Jiang YY, Sun QY, Cao YB

Drug Design, Development and Therapy 2014, 8:1047-1059

Published Date: 6 August 2014

Clinical utility of erlotinib for the treatment of non-small-cell lung cancer in Japanese patients: current evidence

Togashi Y, Hayashi H, Nakagawa K, Nishio K

Drug Design, Development and Therapy 2014, 8:1037-1046

Published Date: 31 July 2014

Antimycobacterial, antimicrobial, and biocompatibility properties of para-aminosalicylic acid with zinc layered hydroxide and Zn/Al layered double hydroxide nanocomposites

Saifullah B, El Zowalaty ME, Arulselvan P, Fakurazi S, Webster TJ, Geilich BM, Hussein MZ

Drug Design, Development and Therapy 2014, 8:1029-1036

Published Date: 28 July 2014

Potential roles of GPR120 and its agonists in the management of diabetes

Zhang D, Leung PS

Drug Design, Development and Therapy 2014, 8:1013-1027

Published Date: 29 July 2014

Novel artificial cell microencapsulation of a complex gliclazide-deoxycholic bile acid formulation: a characterization study

Mooranian A, Negrulj R, Chen-Tan N, Al-Sallami HS, Fang Z, Mukkur T, Mikov M, Golocorbin-Kon S, Fakhoury M, Arfuso F, Al-Salami H

Drug Design, Development and Therapy 2014, 8:1003-1012

Published Date: 28 July 2014

Carbonic anhydrase IX-directed immunoliposomes for targeted drug delivery to human lung cancer cells in vitro

Wong BCK, Zhang H, Qin L, Chen H, Fang C, Lu A, Yang Z

Drug Design, Development and Therapy 2014, 8:993-1001

Published Date: 22 July 2014

Sulforaphane reverses glucocorticoid-induced apoptosis in osteoblastic cells through regulation of the Nrf2 pathway

Lin H, Wei B, Li GS, Zheng JC, Sun JC, Chu JQ, Zeng R, Niu YR

Drug Design, Development and Therapy 2014, 8:973-982

Published Date: 19 July 2014

Evaluation of the biological activity of novel monocationic fluoroaryl-2,2’-bichalcophenes and their analogues

Hussin WA, Ismail MA, Alzahrani AM, El-Sayed WM

Drug Design, Development and Therapy 2014, 8:963-972

Published Date: 17 July 2014

Pustular drug eruption due to Panax notoginseng saponins

Yin ZQ, Ma LW, Xu JL, Xia JP, Luo D

Drug Design, Development and Therapy 2014, 8:957-961

Published Date: 16 July 2014

The load and release characteristics on a strong cationic ion-exchange fiber: kinetics, thermodynamics, and influences

Yuan J, Gao Y, Wang X, Liu H, Che X, Xu L, Yang Y, Wang Q, Wang Y, Li S

Drug Design, Development and Therapy 2014, 8:945-955

Published Date: 16 July 2014

Prostatic urethral angle might be a predictor of treatment efficacy of α-blockers in men with lower urinary tract symptoms

Hou CP, Chen CL, Lin YH, Tsai YL, Chang PL, Juang HH, Tsui KH

Drug Design, Development and Therapy 2014, 8:937-943

Published Date: 15 July 2014

A preliminary study of painless and effective transdermal botulinum toxin A delivery by jet nebulization for treatment of primary hyperhidrosis

Iannitti T, Palmieri B, Aspiro A, Di Cerbo A

Drug Design, Development and Therapy 2014, 8:931-935

Published Date: 14 July 2014

Profile and potential of ixabepilone in the treatment of pancreatic cancer

Smaglo BG, Pishvaian MJ

Drug Design, Development and Therapy 2014, 8:923-930

Published Date: 14 July 2014

Design of oral agents for the management of multiple sclerosis: benefit and risk assessment for dimethyl fumarate

Nicholas JA, Boster AL, Imitola J, O'Connell C, Racke MK

Drug Design, Development and Therapy 2014, 8:897-908

Published Date: 7 July 2014

Virologic breakthrough in a patient with chronic hepatitis B by combination treatment with tenofovir disoproxil fumarate and entecavir

Suzuki F, Sezaki H, Akuta N, Suzuki Y, Kawamura Y, Hosaka T, Kobayashi M, Saitoh S, Arase Y, Ikeda K, Kobayashi M, Watahiki S, Mineta R, Suzuki Y, Kumada H

Drug Design, Development and Therapy 2014, 8:869-873

Published Date: 30 June 2014

Novel nanocrystal formulation of megestrol acetate has improved bioavailability compared with the conventional micronized formulation in the fasting state

Jang K, Yoon S, Kim SE, Cho JY, Yoon SH, Lim KS, Yu KS, Jang IJ, Lee H

Drug Design, Development and Therapy 2014, 8:851-858

Published Date: 25 June 2014

Quetiapine for acute bipolar depression: a systematic review and meta-analysis

Suttajit S, Srisurapanont M, Maneeton N, Maneeton B

Drug Design, Development and Therapy 2014, 8:827-838

Published Date: 25 June 2014

Design of a new therapy to treat snake envenomation

Shahidi Bonjar L

Drug Design, Development and Therapy 2014, 8:819-825

Published Date: 18 June 2014

Use of metformin and vildagliptin for treatment of type 2 diabetes in the elderly

Sicras-Mainar A, Navarro-Artieda R

Drug Design, Development and Therapy 2014, 8:811-818

Published Date: 18 June 2014

Vemurafenib: an evidence-based review of its clinical utility in the treatment of metastatic melanoma

Swaika A, Crozier JA, Joseph RW

Drug Design, Development and Therapy 2014, 8:775-787

Published Date: 16 June 2014

Review of nemonoxacin with special focus on clinical development

Qin X, Huang H

Drug Design, Development and Therapy 2014, 8:765-774

Published Date: 5 July 2014

Thrombolytic treatment (alteplase; rt-PA) in acute massive pulmonary embolism and cardiopulmonary arrest

Dirican A, Ozkaya S, Atas AE, Ulu EK, Kitapci I, Ece F

Drug Design, Development and Therapy 2014, 8:759-763

Published Date: 12 June 2014

Mapracorat, a selective glucocorticoid receptor agonist, causes apoptosis of eosinophils infiltrating the conjunctiva in late-phase experimental ocular allergy

Baiula M, Bedini A, Baldi J, Cavet ME, Govoni P, Spampinato S

Drug Design, Development and Therapy 2014, 8:745-757

Published Date: 10 June 2014

The new concepts on overcoming drug resistance in lung cancer

Zhang W, Lei P, Dong X, Xu C

Drug Design, Development and Therapy 2014, 8:735-744

Published Date: 6 June 2014

Evaluation of cytotoxic and chemotherapeutic properties of boldine in breast cancer using in vitro and in vivo models

Paydar M, Kamalidehghan B, Wong YL, Wong WF, Looi CY, Mustafa MR

Drug Design, Development and Therapy 2014, 8:719-733

Published Date: 6 June 2014

Optimization of biguanide derivatives as selective antitumor agents blocking adaptive stress responses in the tumor microenvironment

Narise K, Okuda K, Enomoto Y, Hirayama T, Nagasawa H

Drug Design, Development and Therapy 2014, 8:701-717

Published Date: 6 June 2014

Ivabradine, coronary artery disease, and heart failure: beyond rhythm control

Scicchitano P, Cortese F, Ricci G, Carbonara S, Moncelli M, Iacoviello M, Cecere A, Gesualdo M, Zito A, Caldarola P, Scrutinio D, Lagioia R, Riccioni G, Ciccone MM

Drug Design, Development and Therapy 2014, 8:689-700

Published Date: 3 June 2014

GLP-1(28-36)amide, the Glucagon-like peptide-1 metabolite: friend, foe, or pharmacological folly?

Taing MW, Rose FJ, Whitehead JP

Drug Design, Development and Therapy 2014, 8:677-688

Published Date: 3 June 2014

Progress of clinical research on targeted therapy combined with thoracic radiotherapy for non-small-cell lung cancer

Zhuang HQ, Zhao XZ, Zhao LJ, Chang JY, Wang P

Drug Design, Development and Therapy 2014, 8:667-675

Published Date: 29 May 2014

Evaluation of ceftiofur–PHBV microparticles in rats

Vilos C, Constandil L, Rodas PI, Cantin M, Zepeda K, Herrera N, Velasquez LA

Drug Design, Development and Therapy 2014, 8:651-666

Published Date: 29 May 2014

Neurotherapeutic activity of the recombinant heat shock protein Hsp70 in a model of focal cerebral ischemia in rats

Shevtsov MA, Nikolaev BP, Yakovleva LY, Dobrodumov AV, Dayneko AS, Shmonin AA, Vlasov TD, Melnikova EV, Vilisov AD, Guzhova IV, Ischenko AM, Mikhrina AL, Galibin OV, Yakovenko IV, Margulis BA

Drug Design, Development and Therapy 2014, 8:639-650

Published Date: 28 May 2014

Anxiolytic and antidepressant-like activities of the novel and potent non-imidazole histamine H3 receptor antagonist ST-1283

Bahi A, Schwed JS, Walter M, Stark H, Sadek B

Drug Design, Development and Therapy 2014, 8:627-637

Published Date: 28 May 2014

Is increasing the dose of Entecavir effective in partial virological responders?

Erturk A, Adnan Akdogan R, Parlak E, Cure E, Cumhur Cure M, Ozturk C

Drug Design, Development and Therapy 2014, 8:621-625

Published Date: 29 May 2014

Quinoxaline-substituted chalcones as new inhibitors of breast cancer resistance protein ABCG2: polyspecificity at B-ring position

Winter E, Gozzi GJ, Chiaradia-Delatorre LD, Daflon-Yunes N, Terreux R, Gauthier C, Mascarello A, Leal PC, Cadena SM, Yunes RA, Nunes RJ, Creczynski-Pasa TB, Di Pietro A

Drug Design, Development and Therapy 2014, 8:609-619

Published Date: 27 May 2014

Cytoprotective effect of selective small-molecule caspase inhibitors against staurosporine-induced apoptosis

Wu J, Wang Y, Liang S, Ma H

Drug Design, Development and Therapy 2014, 8:583-600

Published Date: 24 May 2014

Pharmacoinformatics elucidation of potential drug targets against migraine to target ion channel protein KCNK18

Sehgal SA, Hassan M, Rashid S

Drug Design, Development and Therapy 2014, 8:571-581

Published Date: 21 May 2014

Molecular pharmacodynamics of new oral drugs used in the treatment of multiple sclerosis

di Nuzzo L, Orlando R, Nasca C, Nicoletti F

Drug Design, Development and Therapy 2014, 8:555-568

Published Date: 19 May 2014

Protective effect of picroside II on myocardial ischemia reperfusion injury in rats

Wu N, Li W, Shu W, Jia D

Drug Design, Development and Therapy 2014, 8:545-554

Published Date: 14 May 2014

Effect of MMX® mesalamine coadministration on the pharmacokinetics of amoxicillin, ciprofloxacin XR, metronidazole, and sulfamethoxazole: results from four randomized clinical trials

Pierce D, Corcoran M, Martin P, Barrett K, Inglis S, Preston P, Thompson TN, Willsie SK

Drug Design, Development and Therapy 2014, 8:529-543

Published Date: 14 May 2014

The effects of sulodexide on both clinical and molecular parameters in patients with mixed arterial and venous ulcers of lower limbs

Serra R, Gallelli L, Conti A, De Caridi G, Massara M, Spinelli F, Buffone G, Caliò FG, Amato B, Ceglia S, Spaziano G, Scaramuzzino L, Ferrarese AG, Grande R, de Franciscis S

Drug Design, Development and Therapy 2014, 8:519-527

Published Date: 13 May 2014

Synthesis, antimicrobial, and anti-inflammatory activity, of novel S-substituted and N-substituted 5-(1-adamantyl)-1,2,4-triazole-3-thiols

Al-Abdullah ES, Asiri HH, Lahsasni S, Habib EE, Ibrahim TM, El-Emam AA

Drug Design, Development and Therapy 2014, 8:505-518

Published Date: 12 May 2014

Identification of a novel potential antitumor activity of gossypol as an APE1/Ref-1 inhibitor

Qian CY, Li MX, Sui JD, Ren T, Li Z, Zhang L, Zhou LW, Cheng Y, Wang D

Drug Design, Development and Therapy 2014, 8:485-496

Published Date: 9 May 2014

P-glycoprotein- and organic anion-transporting polypeptide-mediated transport of periplocin may lead to drug–herb/drug–drug interactions

Liang S, Deng FC, Xing HY, Wen H, Shi XY, Martey ON, Koomson E, He X

Drug Design, Development and Therapy 2014, 8:475-483

Published Date: 9 May 2014

Improving anticancer efficacy of (-)-epigallocatechin-3-gallate gold nanoparticles in murine B16F10 melanoma cells

Chen CC, Hsieh DS, Huang KJ, Chan YL, Hong PD, Yeh MK, Wu CJ

Drug Design, Development and Therapy 2014, 8:459-474

Published Date: 8 May 2014

Inhibition of B7-1 (CD80) by RhuDex® reduces lipopolysaccharide-mediated inflammation in human atherosclerotic lesions

Doesch AO, Zhao L, Gleissner CA, Akhavanpoor M, Rohde D, Okuyucu D, Hakimi M, Dengler TJ, Katus HA, Erbel C

Drug Design, Development and Therapy 2014, 8:447-457

Published Date: 12 May 2014

Linagliptin: from bench to bedside

Doupis J

Drug Design, Development and Therapy 2014, 8:431-446

Published Date: 5 May 2014

Topical infliximab for the suppression of wound healing following experimental glaucoma filtration surgery

Turgut B, Eren K, Akın MM, Demir T, Kobat S

Drug Design, Development and Therapy 2014, 8:421-429

Published Date: 2 May 2014

Combined isosorbide dinitrate and ibuprofen as a novel therapy for muscular dystrophies: evidence from Phase I studies in healthy volunteers

Cossu MV, Cattaneo D, Fucile S, Pellegrino P, Baldelli S, Cozzi V, Capetti A, Clementi E

Drug Design, Development and Therapy 2014, 8:411-419

Published Date: 2 May 2014

Formulation development for the orexin receptor antagonist almorexant: assessment in two clinical studies

Dingemanse J, Gehin M, Cruz HG, Hoever P

Drug Design, Development and Therapy 2014, 8:397-403

Published Date: 28 April 2014

Effects of switching from prandial premixed insulin therapy to basal plus two times bolus insulin therapy on glycemic control and quality of life in patients with type 2 diabetes mellitus

Ito H, Abe M, Antoku S, Omoto T, Shinozaki M, Nishio S, Mifune M, Togane M

Drug Design, Development and Therapy 2014, 8:391-396

Published Date: 23 April 2014

Triazole derivatives with improved in vitro antifungal activity over azole drugs

Yu S, Chai X, Wang Y, Cao Y, Zhang J, Wu Q, Zhang D, Jiang Y, Yan T, Sun Q

Drug Design, Development and Therapy 2014, 8:383-390

Published Date: 10 April 2014

Discovery and evaluation of asymmetrical monocarbonyl analogs of curcumin as anti-inflammatory agents

Zhang Y, Zhao C, He W, Wang Z, Fang Q, Xiao B, Liu Z, Liang G, Yang S

Drug Design, Development and Therapy 2014, 8:373-382

Published Date: 4 April 2014

Fc-fusion technology and recombinant FVIII and FIX in the management of the hemophilias

Mancuso ME, Mannucci PM

Drug Design, Development and Therapy 2014, 8:365-371

Published Date: 28 March 2014

Tocilizumab in the treatment of rheumatoid arthritis and beyond

Shetty A, Hanson R, Korsten P, Shawagfeh M, Arami S, Volkov S, Vila O, Swedler W, Shunaigat AN, Smadi S, Sawaqed R, Perkins D, Shahrara S, Sweiss NJ

Drug Design, Development and Therapy 2014, 8:349-364

Published Date: 28 March 2014

Anti-TNF therapy for juvenile idiopathic arthritis-related uveitis

Semeraro F, Arcidiacono B, Nascimbeni G, Angi M, Parolini B, Costagliola C

Drug Design, Development and Therapy 2014, 8:341-348

Published Date: 24 March 2014

Tetrandrine protects mouse retinal ganglion cells from ischemic injury

Li WY, Yang C, Lu J, Huang P, Barnstable CJ, Zhang C, Zhang SS

Drug Design, Development and Therapy 2014, 8:327-339

Published Date: 21 March 2014

Differential microRNA expression signatures and cell type-specific association with Taxol resistance in ovarian cancer cells

Kim YW, Kim EY, Jeon D, Liu JL, Kim H, Choi JW, Ahn WS

Drug Design, Development and Therapy 2014, 8:293-314

Published Date: 24 February 2014

Ulipristal acetate: a novel pharmacological approach for the treatment of uterine fibroids

Biglia N, Carinelli S, Maiorana A, D'Alonzo M, Lo Monte G, Marci R

Drug Design, Development and Therapy 2014, 8:285-292

Published Date: 20 February 2014

Paclitaxel: new uses for an old drug

Zhang D, Yang R, Wang S, Dong Z

Drug Design, Development and Therapy 2014, 8:279-284

Published Date: 20 February 2014

Combining rimonabant and fentanyl in a single entity: preparation and pharmacological results

Fernández-Fernández C, Callado LF, Girón R, Sánchez E, Erdozain AM, López-Moreno JA, Morales P, Rodríguez de Fonseca F, Fernández-Ruiz J, Goya P, Meana JJ, Martín MI, Jagerovic N

Drug Design, Development and Therapy 2014, 8:263-277

Published Date: 20 February 2014

Insulin induces drug resistance in melanoma through activation of the PI3K/Akt pathway

Chi M, Ye Y, Zhang XD, Chen J

Drug Design, Development and Therapy 2014, 8:255-262

Published Date: 17 February 2014

Efficacy and safety of febuxostat in the treatment of hyperuricemia in stable kidney transplant recipients

Sofue T, Inui M, Hara T, Nishijima Y, Moriwaki K, Hayashida Y, Ueda N, Nishiyama A, Kakehi Y, Kohno M

Drug Design, Development and Therapy 2014, 8:245-253

Published Date: 17 February 2014

Effect of vildagliptin add-on treatment to metformin on plasma asymmetric dimethylarginine in type 2 diabetes mellitus patients

Cakirca M, Karatoprak C, Zorlu M, Kiskac M, Kanat M, Cikrikcioglu MA, Soysal P, Hursitoglu M, Camli AA, Erkoc R, Abdul-Ghani M

Drug Design, Development and Therapy 2014, 8:239-243

Published Date: 14 February 2014

Characterization of renal biomarkers for use in clinical trials: biomarker evaluation in healthy volunteers

Brott DA, Adler SH, Arani R, Lovick SC, Pinches M, Furlong ST

Drug Design, Development and Therapy 2014, 8:227-237

Published Date: 13 February 2014

Sinonasal inhalation of tobramycin vibrating aerosol in cystic fibrosis patients with upper airway Pseudomonas aeruginosa colonization: results of a randomized, double-blind, placebo-controlled pilot study

Mainz JG, Schädlich K, Schien C, Michl R, Schelhorn-Neise P, Koitschev A, Koitschev C, Keller PM, Riethmüller J, Wiedemann B, Beck JF

Drug Design, Development and Therapy 2014, 8:209-217

Published Date: 10 February 2014

Omalizumab, an anti-immunoglobulin E antibody: state of the art

Incorvaia C, Mauro M, Russello M, Formigoni C, Riario-Sforza GG, Ridolo E

Drug Design, Development and Therapy 2014, 8:197-207

Published Date: 7 February 2014

Changes in surface expression of N-methyl-D-aspartate receptors in the striatum in a rat model of Parkinson's disease

Gan J, Qi C, Mao LM, Liu ZG

Drug Design, Development and Therapy 2014, 8:165-173

Published Date: 17 January 2014

Novel N-substituted aminobenzamide scaffold derivatives targeting the dipeptidyl peptidase-IV enzyme

Al-Balas QA, Sowaileh MF, Hassan MA, Qandil AM, Alzoubi KH, Mhaidat NM, Almaaytah AM, Khabour OF

Drug Design, Development and Therapy 2014, 8:129-163

Published Date: 16 January 2014

Comparative steady-state pharmacokinetic study of an extended-release formulation of itopride and its immediate-release reference formulation in healthy volunteers

Yoon S, Lee H, Kim TE, Lee S, Chee DH, Cho JY, Yu KS, Jang IJ

Drug Design, Development and Therapy 2014, 8:123-128

Published Date: 15 January 2014

Transdermal testosterone replacement therapy in men

Ullah MI, Riche DM, Koch CA

Drug Design, Development and Therapy 2014, 8:101-112

Published Date: 9 January 2014

Rituximab for the treatment of rheumatoid arthritis: an update

Mok CC

Drug Design, Development and Therapy 2014, 8:87-100

Published Date: 27 December 2013

Overview of clinical use and side effect profile of valsartan in Chinese hypertensive patients

Huang QF, Li Y, Wang JG

Drug Design, Development and Therapy 2014, 8:79-86

Published Date: 30 December 2013

Development and characterization of a gastroretentive dosage form composed of chitosan and hydroxyethyl cellulose for alendronate

Chen YC, Ho HO, Chiu CC, Sheu MT

Drug Design, Development and Therapy 2014, 8:67-78

Published Date: 27 December 2013

Development and use of sulodexide in vascular diseases: implications for treatment

Coccheri S, Mannello F

Drug Design, Development and Therapy 2014, 8:49-65

Published Date: 24 December 2013

(+)-Grandifloracin, an antiausterity agent, induces autophagic PANC-1 pancreatic cancer cell death

Ueda JY, Athikomkulchai S, Miyatake R, Saiki I, Esumi H, Awale S

Drug Design, Development and Therapy 2014, 8:39-47

Published Date: 18 December 2013

Lixisenatide as add-on therapy to basal insulin

Brown DX, Butler EL, Evans M

Drug Design, Development and Therapy 2014, 8:25-38

Published Date: 13 December 2013

Clinical utility of entecavir for chronic hepatitis B in Chinese patients

Wang JY

Drug Design, Development and Therapy 2014, 8:13-24

Published Date: 12 December 2013

Therapeutic potentials of naringin on polymethylmethacrylate induced osteoclastogenesis and osteolysis, in vitro and in vivo assessments

Li N, Xu Z, Wooley PH, Zhang J, Yang SY

Drug Design, Development and Therapy 2014, 8:1-11

Published Date: 10 December 2013

Disease-modifying drugs in Alzheimer's disease

Ghezzi L, Scarpini E, Galimberti D

Drug Design, Development and Therapy 2013, 7:1471-1479

Published Date: 6 December 2013

P-glycoprotein alters blood–brain barrier penetration of antiepileptic drugs in rats with medically intractable epilepsy

Ma A, Wang C, Chen Y, Yuan W

Drug Design, Development and Therapy 2013, 7:1447-1454

Published Date: 3 December 2013

Atomoxetine affects transcription/translation of the NMDA receptor and the norepinephrine transporter in the rat brain – an in vivo study

Udvardi PT, Föhr KJ, Henes C, Liebau S, Dreyhaupt J, Boeckers TM, Ludolph AG

Drug Design, Development and Therapy 2013, 7:1433-1446

Published Date: 4 December 2013

Combined letrozole and clomiphene versus letrozole and clomiphene alone in infertile patients with polycystic ovary syndrome

Hajishafiha M, Dehghan M, Kiarang N, Sadegh-Asadi N, Shayegh SN, Ghasemi-Rad M

Drug Design, Development and Therapy 2013, 7:1427-1431

Published Date: 3 December 2013

Conversion to generic cyclosporine A in stable chronic patients after heart transplantation

Kraeuter M, Helmschrott M, Erbel C, Gleissner CA, Frankenstein L, Schmack B, Ruhparwar A, Ehlermann P, Katus HA, Doesch AO

Drug Design, Development and Therapy 2013, 7:1421-1426

Published Date: 28 November 2013

Estrogen receptor modulatory effects of germinated brown rice bioactives in the uterus of rats through the regulation of estrogen-induced genes

Muhammad SI, Maznah I, Mahmud RB, Saeed MI, Imam MU, Ishaka A

Drug Design, Development and Therapy 2013, 7:1409-1420

Published Date: 2 December 2013

Canagliflozin: a novel treatment option for type 2 diabetes

Dietrich E, Powell J, Taylor JR

Drug Design, Development and Therapy 2013, 7:1399-1408

Published Date: 22 November 2013

Can the anti-inflammatory activities of β2-agonists be harnessed in the clinical setting?

Theron AJ, Steel HC, Tintinger GR, Feldman C, Anderson R

Drug Design, Development and Therapy 2013, 7:1387-1398

Published Date: 22 November 2013

In vitro and in vivo characterization of the antimalarial lead compound SSJ-183 in Plasmodium models

Schleiferböck S, Scheurer C, Ihara M, Itoh I, Bathurst I, Burrows JN, Fantauzzi P, Lotharius J, Charman SA, Morizzi J, Shackleford DM, White KL, Brun R, Wittlin S

Drug Design, Development and Therapy 2013, 7:1377-1384

Published Date: 15 November 2013

Antituberculosis nanodelivery system with controlled-release properties based on para-amino salicylate–zinc aluminum-layered double-hydroxide nanocomposites

Saifullah B, Hussein MZ, Hussein-Al-Ali SH, Arulselvan P, Fakurazi S

Drug Design, Development and Therapy 2013, 7:1365-1375

Published Date: 13 November 2013

Profile of gantenerumab and its potential in the treatment of Alzheimer's disease

Novakovic D, Feligioni M, Scaccianoce S, Caruso A, Piccinin S, Schepisi C, Errico F, Mercuri NB, Nicoletti F, Nisticò R

Drug Design, Development and Therapy 2013, 7:1359-1364

Published Date: 13 November 2013

Animal models of ulcerative colitis and their application in drug research

Low D, Nguyen DD, Mizoguchi E

Drug Design, Development and Therapy 2013, 7:1341-1357

Published Date: 12 November 2013

New and emerging treatments for symptomatic tardive dyskinesia

Rana AQ, Chaudry ZM, Blanchet PJ

Drug Design, Development and Therapy 2013, 7:1329-1340

Published Date: 6 November 2013

Heart rate reduction for 36 months with ivabradine reduces left ventricular mass in cardiac allograft recipients: a long-term follow-up study

Doesch AO, Mueller S, Erbel C, Gleissner CA, Frankenstein L, Hardt S, Ruhparwar A, Ehlermann P, Dengler T, Katus HA

Drug Design, Development and Therapy 2013, 7:1323-1328

Published Date: 5 November 2013

Molecularly targeted drugs for metastatic colorectal cancer

Cheng YD, Yang H, Chen GQ, Zhang ZC

Drug Design, Development and Therapy 2013, 7:1315-1322

Published Date: 1 November 2013

Bozepinib, a novel small antitumor agent, induces PKR-mediated apoptosis and synergizes with IFNα triggering apoptosis, autophagy and senescence

Marchal JA, Carrasco E, Ramírez A, Jiménez G, Olmedo C, Peran M, Agil A, Conejo-García A, Cruz-López O, Campos JM, García MA

Drug Design, Development and Therapy 2013, 7:1301-1313

Published Date: 29 October 2013

Glycyrrhetinic acid-modified chitosan nanoparticles enhanced the effect of 5-fluorouracil in murine liver cancer model via regulatory T-cells

Cheng M, Xu H, Wang Y, Chen H, He B, Gao X, Li Y, Han J, Zhang Z

Drug Design, Development and Therapy 2013, 7:1287-1299

Published Date: 25 October 2013

Advances in the proteomic discovery of novel therapeutic targets in cancer

Guo S, Zou J, Wang G

Drug Design, Development and Therapy 2013, 7:1259-1271

Published Date: 24 October 2013

Increased adherence eight months after switch from twice daily calcineurin inhibitor based treatment to once daily modified released tacrolimus in heart transplantation

Doesch AO, Mueller S, Akyol C, Erbel C, Frankenstein L, Ruhparwar A, Ehlermann P, Dengler TJ, Katus HA

Drug Design, Development and Therapy 2013, 7:1253-1258

Published Date: 21 October 2013

Antioxidant effect of Arabic gum against mercuric chloride-induced nephrotoxicity

Gado AM, Aldahmash BA

Drug Design, Development and Therapy 2013, 7:1245-1252

Published Date: 21 October 2013

Intestinal absorption and biliary elimination of glycyrrhizic acid diethyl ester in rats

Koga K, Kawamura M, Iwase H, Yoshikawa N

Drug Design, Development and Therapy 2013, 7:1235-1243

Published Date: 21 October 2013

Daclatasvir: potential role in hepatitis C

Lee C

Drug Design, Development and Therapy 2013, 7:1223-1233

Published Date: 16 October 2013

Current and future G protein-coupled receptor signaling targets for heart failure therapy

Siryk-Bathgate A, Dabul S, Lymperopoulos A

Drug Design, Development and Therapy 2013, 7:1209-1222

Published Date: 11 October 2013

New developments in the combination treatment of COPD: focus on umeclidinium/vilanterol

Cazzola M, Segreti A, Matera MG

Drug Design, Development and Therapy 2013, 7:1201-1208

Published Date: 10 October 2013

Phase II study of whole brain radiotherapy with or without erlotinib in patients with multiple brain metastases from lung adenocarcinoma

Zhuang H, Yuan Z, Wang J, Zhao L, Pang Q, Wang P

Drug Design, Development and Therapy 2013, 7:1179-1186

Published Date: 8 October 2013

8-Hydroxyquinolines: a review of their metal chelating properties and medicinal applications

Prachayasittikul V, Prachayasittikul S, Ruchirawat S, Prachayasittikul V

Drug Design, Development and Therapy 2013, 7:1157-1178

Published Date: 4 October 2013

The effect of prostaglandin analogs on the biomechanical properties and central thickness of the cornea of patients with open-angle glaucoma: a 3-year study on 108 eyes

Tsikripis P, Papaconstantinou D, Koutsandrea C, Apostolopoulos M, Georgalas I

Drug Design, Development and Therapy 2013, 7:1149-1156

Published Date: 4 October 2013

Clinical experimentation with aerosol antibiotics: current and future methods of administration

Zarogoulidis P, Kioumis I, Porpodis K, Spyratos D, Tsakiridis K, Huang H, Li Q, Turner JF, Browning R, Hohenforst-Schmidt W, Zarogoulidis K

Drug Design, Development and Therapy 2013, 7:1115-1134

Published Date: 2 October 2013

Advances with microRNAs in Parkinson’s disease research

Ma L, Wei L, Wu F, Hu Z, Liu Z, Yuan W

Drug Design, Development and Therapy 2013, 7:1103-1113

Published Date: 1 October 2013

A novel dimeric thymosin beta 4 with enhanced activities accelerates the rate of wound healing

Xu TJ, Wang Q, Ma XW, Zhang Z, Zhang W, Xue XC, Zhang C, Hao Q, Li WN, Zhang YQ, Li M

Drug Design, Development and Therapy 2013, 7:1075-1088

Published Date: 1 October 2013

Amniotic fluid stem cells morph into a cardiovascular lineage: analysis of a chemically induced cardiac and vascular commitment

Maioli M, Contini G, Santaniello S, Bandiera P, Pigliaru G, Sanna R, Rinaldi S, Delitala AP, Montella A, Bagella L, Ventura C

Drug Design, Development and Therapy 2013, 7:1063-1073

Published Date: 27 September 2013

New structure–activity relationships of chalcone inhibitors of breast cancer resistance protein: polyspecificity toward inhibition and critical substitutions against cytotoxicity

Rangel LP, Winter E, Gauthier C, Terreux R, Chiaradia-Delatorre LD, Mascarello A, Nunes RJ, Yunes RA, Creczynski-Pasa TB, Macalou S, Lorendeau D, Baubichon-Cortay H, Ferreira-Pereira A, Di Pietro A

Drug Design, Development and Therapy 2013, 7:1043-1052

Published Date: 30 September 2013

Corticosteroid transdermal delivery to target swelling, edema and inflammation following facial rejuvenation procedures

Iannitti T, Rottigni V, Palmieri B

Drug Design, Development and Therapy 2013, 7:1035-1041

Published Date: 26 September 2013

Preparation and characterization of 6-mercaptopurine-coated magnetite nanoparticles as a drug delivery system

Dorniani D, Hussein MZ, Kura AU, Fakurazi S, Shaari AH, Ahmad Z

Drug Design, Development and Therapy 2013, 7:1015-1026

Published Date: 25 September 2013

Vitamin D in asthma and future perspectives

Huang H, Porpodis K, Zarogoulidis P, Domvri K, Giouleka P, Papaiwannou A, Primikyri S, Mylonaki E, Spyratos D, Hohenforst-Schmidt W, Kioumis I, Zarogoulidis K

Drug Design, Development and Therapy 2013, 7:1003-1013

Published Date: 23 September 2013

Dipeptidyl peptidase-4 inhibitors in type 2 diabetes therapy – focus on alogliptin

Capuano A, Sportiello L, Maiorino MI, Rossi F, Giugliano D, Esposito K

Drug Design, Development and Therapy 2013, 7:989-1001

Published Date: 17 September 2013

Unexpected effects of peripherally administered kynurenic acid on cortical spreading depression and related blood–brain barrier permeability

Oláh G, Herédi J, Menyhárt Á, Czinege Z, Nagy D, Fuzik J, Kocsis K, Knapp L, Krucsó E, Gellért L, Kis Z, Farkas T, Fülöp F, Párdutz Á, Tajti J, Vécsei L, Toldi J

Drug Design, Development and Therapy 2013, 7:981-987

Published Date: 16 September 2013

Long-acting preparations of exenatide

Cai Y, Wei L, Ma L, Huang X, Tao A, Liu Z, Yuan W

Drug Design, Development and Therapy 2013, 7:963-970

Published Date: 5 September 2013

Hologram quantitative structure–activity relationship and comparative molecular field analysis studies within a series of tricyclic phthalimide HIV-1 integrase inhibitors

Magalhães UO, Souza AMT, Albuquerque MG, Brito MA, Bello ML, Cabral LM, Rodrigues CR

Drug Design, Development and Therapy 2013, 7:953-961

Published Date: 5 September 2013

Dissolving and biodegradable microneedle technologies for transdermal sustained delivery of drug and vaccine

Hong X, Wei L, Wu F, Wu Z, Chen L, Liu Z, Yuan W

Drug Design, Development and Therapy 2013, 7:945-952

Published Date: 4 September 2013

Intravenous iron monotherapy for the treatment of non-iron-deficiency anemia in cancer patients undergoing chemotherapy: a pilot study

Abdel-Razeq H, Abbasi S, Saadi I, Jaber R , Abdulelah H

Drug Design, Development and Therapy 2013, 7:939-944

Published Date: 30 August 2013

Development, clinical utility, and place of ivacaftor in the treatment of cystic fibrosis

O’Reilly R, Elphick HE

Drug Design, Development and Therapy 2013, 7:929-937

Published Date: 30 August 2013

Identification of PPARγ ligands with One-dimensional Drug Profile Matching

Kovács D, Simon Z, Hári P, Málnási-Csizmadia A, Hegedűs C, Drimba L, Németh J, Sári R, Szilvássy Z, Peitl B

Drug Design, Development and Therapy 2013, 7:917-928

Published Date: 2 September 2013

Novel N-phenylcarbamothioylbenzamides with anti-inflammatory activity and prostaglandin E2 inhibitory properties

Limban C, Missir AV, Fahelelbom KMS, Al-Tabakha MM, Caproiu MT, Sadek B

Drug Design, Development and Therapy 2013, 7:883-892

Published Date: 28 August 2013

Enzalutamide as a second generation antiandrogen for treatment of advanced prostate cancer

Semenas J, Dizeyi N, Persson JL

Drug Design, Development and Therapy 2013, 7:875-881

Published Date: 27 August 2013

Causes, consequences, and treatment of osteoporosis in men

Banu J

Drug Design, Development and Therapy 2013, 7:849-860

Published Date: 22 August 2013

Bioequivalence study of two formulations of candesartan cilexetil tablet in healthy subjects under fasting conditions

Tjandrawinata RR, Setiawati E, Yunaidi DA, Simanjuntak R, Santoso ID, Susanto LW

Drug Design, Development and Therapy 2013, 7:841-847

Published Date: 20 August 2013

In silico identification of EGFR-T790M inhibitors with novel scaffolds: start with extraction of common features

Xiang M, Lei K, Fan W, Lin Y, He G, Yang M, Chen L, Mo Y

Drug Design, Development and Therapy 2013, 7:789-839

Published Date: 14 August 2013

Update on rescue therapies in patients with lamivudine-resistant chronic hepatitis B

Chao DC, Hu KQ

Drug Design, Development and Therapy 2013, 7:777-788

Published Date: 20 August 2013

Clinical study of etomidate emulsion combined with remifentanil in general anesthesia

Weng D, Huang M, Jiang R, Zhan R, Yang C

Drug Design, Development and Therapy 2013, 7:771-776

Published Date: 20 August 2013

Valproic acid-associated low fibrinogen and delayed intracranial hemorrhage: case report and mini literature review

Chen HF, Xu LP, Luo ZY, Yu ZQ, Li ZY, Cui QY, Qin LM, Ren YY, Shen HS, Tang JQ, Jin LJ, Zhu JJ, Wang J, Wang KY, Wu TQ, Wang ZY

Drug Design, Development and Therapy 2013, 7:767-770

Published Date: 13 August 2013

N-Palmitoylethanolamine depot injection increased its tissue levels and those of other acylethanolamide lipids

Grillo SL, Keereetaweep J, Grillo MA, Chapman KD, Koulen P

Drug Design, Development and Therapy 2013, 7:747-752

Published Date: 12 August 2013

Developing therapeutic approaches for metachromatic leukodystrophy

Patil SA, Maegawa GHB

Drug Design, Development and Therapy 2013, 7:729-745

Published Date: 8 August 2013

Renal thrombotic microangiopathy caused by interferon beta-1a treatment for multiple sclerosis

Mahe J, Meurette A, Moreau A, Vercel C, Jolliet P

Drug Design, Development and Therapy 2013, 7:723-728

Published Date: 7 August 2013

Aflibercept in wet AMD: specific role and optimal use

Semeraro F, Morescalchi F, Duse S, Parmeggiani F, Gambicorti E, Costagliola C

Drug Design, Development and Therapy 2013, 7:711-722

Published Date: 5 August 2013

Mycobacterium marinum: a potential immunotherapy for Mycobacterium tuberculosis infection

Tian WW, Wang QQ, Liu WD, Shen JP, Wang HS

Drug Design, Development and Therapy 2013, 7:669-680

Published Date: 29 July 2013

Quetiapine versus haloperidol in the treatment of delirium: a double-blind, randomized, controlled trial

Maneeton B, Maneeton N, Srisurapanont M, Chittawatanarat K

Drug Design, Development and Therapy 2013, 7:657-667

Published Date: 24 July 2013

Drugs in development for treatment of patients with cancer-related anorexia and cachexia syndrome

Mantovani G, Madeddu C, Maccio A

Drug Design, Development and Therapy 2013, 7:645-656

Published Date: 12 August 2013

Glyphosate and AMPA inhibit cancer cell growth through inhibiting intracellular glycine synthesis

Li Q, Lambrechts MJ, Zhang Q, Liu S, Ge D, Yin R, Xi M, You Z

Drug Design, Development and Therapy 2013, 7:635-643

Published Date: 24 July 2013

Successful application of extracorporeal membrane oxygenation due to pulmonary hemorrhage secondary to granulomatosis with polyangiitis

Hohenforst-Schmidt W, Petermann A, Visouli A, Zarogoulidis P, Darwiche K, Kougioumtzi I, Tsakiridis K, Machairiotis N, Ketteler M, Zarogoulidis K, Brachmann J

Drug Design, Development and Therapy 2013, 7:627-633

Published Date: 24 July 2013

Immunomodifiers in combination with conventional chemotherapy in small cell lung cancer: a Phase II, randomized study

Zarogoulidis K, Ziogas E, Boutsikou E, Zarogoulidis P, Darwiche K, Kontakiotis T, Tsakiridis K, Porpodis K, Latsios D, Chatzizisi O, Karapantzos I, Li Q, Kyriazis G

Drug Design, Development and Therapy 2013, 7:611-617

Published Date: 23 July 2013

Profile of bazedoxifene/conjugated estrogens for the treatment of estrogen deficiency symptoms and osteoporosis in women at risk of fracture

Rossini M, Lello S, Sblendorio I, Viapiana O, Fracassi E, Adami S, Gatti D

Drug Design, Development and Therapy 2013, 7:601-610

Published Date: 22 July 2013

Organelle targeting: third level of drug targeting

Sakhrani NM, Padh H

Drug Design, Development and Therapy 2013, 7:585-599

Published Date: 17 July 2013

Intratumoral chemotherapy for lung cancer: re-challenge current targeted therapies

Hohenforst-Schmidt W, Zarogoulidis P, Darwiche K, Vogl T, Goldberg EP, Huang H, Simoff M, Li Q, Browning R, Turner FJ, Le Pivert P, Spyratos D, Zarogoulidis K, Celikoglu SI, Celikoglu F, Brachmann J

Drug Design, Development and Therapy 2013, 7:571-583

Published Date: 18 July 2013

Effect of ranibizumab on serous and vascular pigment epithelial detachments associated with exudative age-related macular degeneration

Panos GD, Gatzioufas Z, Petropoulos IK, Dardabounis D, Thumann G, Hafezi F

Drug Design, Development and Therapy 2013, 7:565-569

Published Date: 10 July 2013

S-nitroso-N-acetylcysteine attenuates liver fibrosis in experimental nonalcoholic steatohepatitis

Mazo DF, de Oliveira MG, Pereira IV, Cogliati B, Stefano JT, de Souza GF, Rabelo F, Lima FR, Ferreira Alves VA, Carrilho FJ, de Oliveira CP

Drug Design, Development and Therapy 2013, 7:553-563

Published Date: 28 June 2013

Endogenous n 3 polyunsaturated fatty acids PUFAs mitigate ovariectomy-induced bone loss by attenuating bone marrow adipogenesis in FAT1 transgenic mice

Chen TY, Zhang ZM, Zheng XC, Wang L, Huang MJ, Qin S, Chen J, Lai PL, Yang CL, Liu J, Dai YF, Jin DD, Bai XC

Drug Design, Development and Therapy 2013, 7:545-552

Published Date: 28 June 2013

Reducing lung function decline in patients with idiopathic pulmonary fibrosis: potential of nintedanib

Woodcock HV, Molyneaux PL, Maher TM

Drug Design, Development and Therapy 2013, 7:503-510

Published Date: 19 June 2013

Drug-resistant colon cancer cells produce high carcinoembryonic antigen and might not be cancer-initiating cells

Lee HC, Ling QD, Yu WC, Hung CM, Kao TC, Huang YW, Higuchi A

Drug Design, Development and Therapy 2013, 7:491-502

Published Date: 17 June 2013

Resistance to antivascular endothelial growth factor treatment in age-related macular degeneration

Tranos P, Vakalis A, Asteriadis S, Koukoula S, Vachtsevanos A, Perganta G, Georgalas I

Drug Design, Development and Therapy 2013, 7:485-490

Published Date: 17 June 2013

Novel phytochemical–antibiotic conjugates as multitarget inhibitors of Pseudomononas aeruginosa GyrB/ParE and DHFR

Jayaraman P, Sakharkar KR, Lim CS, Siddiqi MI, Dhillon SK, Sakharkar MK

Drug Design, Development and Therapy 2013, 7:449-475

Published Date: 17 June 2013

Osteoporosis – a current view of pharmacological prevention and treatment

Das S, Crockett JC

Drug Design, Development and Therapy 2013, 7:435-448

Published Date: 31 May 2013

Fluocinolone acetonide intravitreal implant for the treatment of diabetic macular edema

Messenger WB, Beardsley RM, Flaxel CJ

Drug Design, Development and Therapy 2013, 7:425-434

Published Date: 24 May 2013

Flurbiprofen benzyl nitrate (NBS-242) inhibits the growth of A-431 human epidermoid carcinoma cells and targets ß-catenin

Nath N, Liu X, Jacobs L, Kashfi K

Drug Design, Development and Therapy 2013, 7:389-396

Published Date: 6 May 2013

Microbubble-mediated ultrasound therapy: a review of its potential in cancer treatment

Ibsen S, Schutt CE, Esener S

Drug Design, Development and Therapy 2013, 7:375-388

Published Date: 3 May 2013

Very rapid effect of pitavastatin on microvascular function in comparison to rosuvastatin: reactive hyperemia peripheral arterial tonometric study

Kono Y, Fukuda S, Shimada K, Nakanishi K, Otsuka K, Kubo T, Jissho S, Taguchi H, Yoshikawa J, Yoshiyama M

Drug Design, Development and Therapy 2013, 7:369-374

Published Date: 3 May 2013

Profile of certolizumab and its potential in the treatment of psoriatic arthritis

Chimenti MS, Saraceno R, Chiricozzi A, Giunta A, Chimenti S, Perricone R

Drug Design, Development and Therapy 2013, 7:339-348

Published Date: 15 April 2013

Current and emerging pharmacological treatments for sarcoidosis: a review

Beegle SH, Barba K, Gobunsuy R, Judson MA

Drug Design, Development and Therapy 2013, 7:325-338

Published Date: 12 April 2013

In vitro and in vivo evaluation of a sublingual fentanyl wafer formulation

Lim SCB, Paech MJ, Sunderland B, Liu Y

Drug Design, Development and Therapy 2013, 7:317-324

Published Date: 12 April 2013

Usefulness of a selective neutrophil elastase inhibitor, sivelestat, in acute lung injury patients with sepsis

Miyoshi S, Hamada H, Ito R, Katayama H, Irifune K, Suwaki T, Nakanishi N, Kanematsu T, Dote K, Aibiki M, Okura T, Higaki J

Drug Design, Development and Therapy 2013, 7:305-316

Published Date: 10 April 2013

Effects of vildagliptin (Galvus®) therapy in patients with type 2 diabetes mellitus after heart transplantation

Gueler I, Mueller S, Helmschrott M, Oeing CU, Erbel C, Frankenstein L, Gleissner C, Ruhparwar A, Ehlermann P, Dengler TJ, Katus HA, Doesch AO

Drug Design, Development and Therapy 2013, 7:297-303

Published Date: 8 April 2013

Management of difficult-to-treat patients with ulcerative colitis: focus on adalimumab

Armuzzi A, Pugliese D, Nardone OM, Guidi L

Drug Design, Development and Therapy 2013, 7:289-296

Published Date: 8 April 2013

Find novel dual-agonist drugs for treating type 2 diabetes by means of cheminformatics

Liu L, Ma Y, Wang RL, Xu WR, Wang SQ, Chou KC

Drug Design, Development and Therapy 2013, 7:279-288

Published Date: 8 April 2013

Phentermine and topiramate for the management of obesity: a review

Cosentino G, Conrad AO, Uwaifo GI

Drug Design, Development and Therapy 2013, 7:267-278

Published Date: 5 April 2013

Potential role of tedizolid phosphate in the treatment of acute bacterial skin infections

Urbina O, Ferrández O, Espona M, Salas E, Ferrández I, Grau S

Drug Design, Development and Therapy 2013, 7:243-265

Published Date: 3 April 2013

Generalized in vitro-in vivo relationship (IVIVR) model based on artificial neural networks

Mendyk A, Tuszyński PK, Polak S, Jachowicz R

Drug Design, Development and Therapy 2013, 7:223-232

Published Date: 27 March 2013

Hepatocyte-targeting gene transfer mediated by galactosylated poly(ethylene glycol)- graft-polyethylenimine derivative

Wang YQ, Su J, Cai WW, Lu P, Yuan LF, Jin T, Chen SY, Sheng J

Drug Design, Development and Therapy 2013, 7:211-221

Published Date: 26 March 2013