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Drug Design, Development and Therapy

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ISSN: 1177-8881

Journal Articles:

- 5,669 records -

Letter

Is Thoracic Paravertebral Block Truly Superior to Erector Spinae Plane Block? Re-Evaluating the Evidence from a Recovery Perspective [Letter]

Ma H, Wei L, Niu J

Drug Design, Development and Therapy 2026, 20:631849

Published Date: 23 June 2026

Original Research

Granisetron Reduces Norepinephrine Requirement for Preventing Post‑Induction Hypotension in Elderly Patients Undergoing Laparoscopic Gastrointestinal Surgery

Zhang Y, Chu M, Zhou Y, Chen G

Drug Design, Development and Therapy 2026, 20:609499

Published Date: 23 June 2026

Letter

Beyond Indication Expansion: Aligning Evidence, Reimbursement, and Access in Multi-Indication Oncology Drugs [Letter]

Yusroni A

Drug Design, Development and Therapy 2026, 20:625668

Published Date: 23 June 2026

Review

Remodeling the Stroma: The Role of ncRNAs in Cancer-Associated Fibroblasts and Therapeutic Implications for Digestive Tumors

Luo K, Hou W, Zhang W

Drug Design, Development and Therapy 2026, 20:600029

Published Date: 23 June 2026

Review

Swarm Intelligence in Drug Discovery Applications: Unlocking Deeper Insights on the Identification and Optimization of Potential Drug Candidates

Gao Z, Ding P, Oguztuzun C, Xu R

Drug Design, Development and Therapy 2026, 20:561251

Published Date: 23 June 2026

Letter

The Bonferroni Paradox: When Secondary Analyses are Held to a Stricter Standard Than the Primary Endpoint [Letter]

Pu Y, Hou D, Niu J

Drug Design, Development and Therapy 2026, 20:633921

Published Date: 23 June 2026

Clinical Trial Report

Effects of Liposomal Bupivacaine for Superficial Parasternial Intercostal Plane Block on Postoperative Stress and Analgesia in Patients Undergoing Median Sternotomy: A Prospective, Randomized, Double-Blind Trial

Yu W, Li Y, Wei A, Chen S, Zhang Y

Drug Design, Development and Therapy 2026, 20:597889

Published Date: 22 June 2026

Review

Tubulin Post-Translational Modifications in Cardiovascular Diseases: Emerging Mechanisms and Therapeutic Modulation by Traditional Chinese Medicine

Qi Y, Zhou Y, Ning X, Ye J, Hu Z, Li L

Drug Design, Development and Therapy 2026, 20:616766

Published Date: 22 June 2026

Clinical Trial Report

Bolus versus Continuous Infusion of Esketamine for Prevention of Postpartum Depression After Caesarean Delivery: A Randomized, Double-Blind, Controlled Trial

Yang J, Yan Q, Zhang T, Hu Y, Peng F, Zhao R, Deng M, Ren L

Drug Design, Development and Therapy 2026, 20:601347

Published Date: 22 June 2026

Clinical Trial Report

Discharge Readiness After Propofol with or without Esketamine for Flexible Bronchoscopy: A Randomized Non-Inferiority Trial

Zhang X, Chen L, Chen Z, Yang J, Zheng T, Lin W, Guan J, Yao Y

Drug Design, Development and Therapy 2026, 20:612153

Published Date: 22 June 2026

Original Research

Enhanced Recovery and Postoperative Analgesia After Laparoscopic Myomectomy: A Randomized Controlled Trial Comparing Total Intravenous Anesthesia, Transversus Abdominis Plane Block with Rectus Sheath Block, and Quadratus Lumborum Block

Zeng C, Ling G, Huang C, Pan T, Tang Y, Kong F, Dai L, Xiao W, Liang Y, Gong Z

Drug Design, Development and Therapy 2026, 20:622304

Published Date: 22 June 2026

Original Research

Population Pharmacokinetics and Dose Optimization of Vancomycin in Adult Cancer Patients

Gao J, Gao X, Xu Y, Feng Z, Wang P, Gong W, Wang M

Drug Design, Development and Therapy 2026, 20:608206

Published Date: 20 June 2026

Review

Molecular Mechanisms Underlying the Anti-Diabetic Effects of Astragaloside IV: A Focus on Signaling Pathways

Chen C, He P, Liu Y, Ma J, Zhai H, Yu R

Drug Design, Development and Therapy 2026, 20:600460

Published Date: 20 June 2026

Review

From Phytochemistry to Drug Discovery: A Systematic Review of Multitarget Pharmacology and Lead Compound Prioritization of Piper crocatum Ruiz & Pav

Apriyanti E, Kurnia D, Al-Anshori J, Takaya A

Drug Design, Development and Therapy 2026, 20:611626

Published Date: 20 June 2026

Letter

Remimazolam versus Propofol in Renal Allograft Surgery: A Methodological Commentary [Letter]

Yang W, Yu S, Li J

Drug Design, Development and Therapy 2026, 20:633660

Published Date: 19 June 2026

Review

Artificial Intelligence in Selected Domains of Drug Discovery: A Critical Narrative Review

Bin Abdulqader MI, Alsaqabi AA, Mohammed AE, Alghamdi SS

Drug Design, Development and Therapy 2026, 20:607228

Published Date: 19 June 2026

Original Research

In-vivo Antioxidant Effects of Emodin on Ischemia-Reperfusion Injury of Rat’s Skeletal Muscle

Yiğit D, Oktar GL, Demirtaş H, Özer A, Küçük A, Yığman Z, Tekin E, Arslan M

Drug Design, Development and Therapy 2026, 20:618630

Published Date: 19 June 2026

Review

Artemisinin-Related Therapeutic Strategies for Autoimmune Thyroiditis: Chemokine–Receptor Networks, Spatial Thyroid Biology, and Molecular Mechanisms

Sun Y, Yang X, Zhu Q, Yang R

Drug Design, Development and Therapy 2026, 20:614133

Published Date: 18 June 2026

Original Research

Optimizing Flumatinib Therapy in Chinese Chronic-Phase Chronic Myeloid Leukemia Based on Therapeutic Drug Monitoring

Cheng F, Wang F, Cui Z, Li Q, Liu X, Li W

Drug Design, Development and Therapy 2026, 20:612207

Published Date: 18 June 2026

Retraction

The Pan-Inhibitor of Aurora Kinases Danusertib Induces Apoptosis and Autophagy and Suppresses Epithelial-to-Mesenchymal Transition in Human Breast Cancer Cells [Retraction]

Li J, Yang Y, Liu Q, Zhou Z, Pan S, He Z, Zhang X, Yang T, Pan S, Duan W, He S, Chen X, Qiu J, Zhou S

Drug Design, Development and Therapy 2026, 20:633634

Published Date: 18 June 2026

Retraction

Plumbagin Induces Cell Cycle Arrest and Autophagy and Suppresses Epithelial to Mesenchymal Transition Involving PI3K/Akt/mTOR-Mediated Pathway in Human Pancreatic Cancer Cells [Retraction]

Wang F, Wang Q, Zhou Z, Yu S, Pan S, He Z, Zhang X, Wang D, Yang Y, Yang T, Sun T, Li M, Qiu J, Zhou S

Drug Design, Development and Therapy 2026, 20:633642

Published Date: 18 June 2026

Retraction

Alisertib Induces Cell Cycle Arrest and Autophagy and Suppresses Epithelial-to-Mesenchymal Transition Involving PI3K/Akt/mTOR and Sirtuin 1-Mediated signaling pathways in Human Pancreatic Cancer Cells [Retraction]

Wang F, Li H, Yan X, Zhou Z, Yi Z, He Z, Pan S, Yang Y, Wang Z, Zhang X, Yang T, Qiu J, Zhou S

Drug Design, Development and Therapy 2026, 20:633636

Published Date: 18 June 2026

Review

Peptides in the Diagnosis and Treatment of Pancreatic Cancer and Other Pancreatic Diseases from Basic Research to Clinical Translation

Gan G, Zhang X, Xu Y, Bai K, Yan X, Dong D, Xiang H, Tao X

Drug Design, Development and Therapy 2026, 20:610190

Published Date: 18 June 2026

Review

Nanocarrier-Mediated Delivery Systems of Phytochemicals to Enhance and Accelerate Diabetic Wound Healing Processes

Wahyuningsih ES, Muhaimin M, Chaerunisaa AY, Khairinisa MA

Drug Design, Development and Therapy 2026, 20:607020

Published Date: 18 June 2026

Clinical Trial Report

Effect of Oliceridine Fumarate for Patient-Controlled Intravenous Analgesia on Gastrointestinal Function in Laparoscopic Radical Gastrectomy Surgery: A Randomized, Double-Blind, Controlled Trial

Wang C, Xu WD, Lu XL, Lei WP, Sun JL, Huang YQ

Drug Design, Development and Therapy 2026, 20:606257

Published Date: 18 June 2026

Letter

Statistical Issues in the Oliceridine versus Sufentanil Trial for Elderly Thoracoscopic Surgery [Letter]

Xu D, Ma H, Hou D

Drug Design, Development and Therapy 2026, 20:632511

Published Date: 17 June 2026

Original Research

Efficacy of Remimazolam for Anesthesia in Patients Undergoing Renal Allograft Transplantation: A Randomized Controlled Trial

Han M, Sun D, Lu D, Huang X, Kang F, Li J

Drug Design, Development and Therapy 2026, 20:611432

Published Date: 16 June 2026

Original Research

Physiologically Based Pharmacokinetic Modeling and Therapeutic Drug Monitoring for Ertapenem Dose Optimization in Hypoalbuminemia Elderly Patients

Du X, Dong Z, Li Y, Wu Y, Wu H

Drug Design, Development and Therapy 2026, 20:611549

Published Date: 16 June 2026

Review

Neurohormonal-Immune Dysregulation in Rosacea: Emerging Perspectives from the Skin-Gut-Brain Axis

Shi L, Li S, Yao X, Zhang Z, Dong Q, Zhang H, Wang X, Bai J, Han H, Fu X, Zheng K, Liang L

Drug Design, Development and Therapy 2026, 20:608151

Published Date: 16 June 2026

Clinical Trial Report

Efficacy and Safety of Ultrasound-Guided Erector Spinae Plane Block at Different Injection Depths for Percutaneous Kyphoplasty: A Randomized Controlled Trial

Liu Y, Yu Y, Gao X, Wang Q, Wang Y, Xia X

Drug Design, Development and Therapy 2026, 20:601168

Published Date: 16 June 2026

Review

Prospects for Neuroprotective Therapies in Glaucoma: Drug Targets and Emerging Clinical Strategies

Rho S, Williams PA

Drug Design, Development and Therapy 2026, 20:612176

Published Date: 16 June 2026

Original Research

Optimizing Colistin Sulfate Dosing in Severe Infections: A Population Pharmacokinetic Model-Guided Approach

Ma Y, Wang Y, Wu X, Wang J, Pang Y, Jia Y, Yang X, Gu J

Drug Design, Development and Therapy 2026, 20:600942

Published Date: 15 June 2026

Letter

Effect of Intraoperative Low-Dose Lidocaine on Mivacurium Requirement in Gynecological Laparoscopy [Letter]

Xu D, Niu J, Hou D

Drug Design, Development and Therapy 2026, 20:630083

Published Date: 15 June 2026

Letter

Methodological Considerations on the Retrospective Cohort Study of Remifentanil-Propofol versus Propofol Alone in Severe Traumatic Brain Injury [Letter]

Şimşek K, Hızal S, Pehlivan MT

Drug Design, Development and Therapy 2026, 20:618201

Published Date: 15 June 2026

Original Research

R-α-Lipoic Acid Attenuates Acetaminophen-Induced Acute Liver Injury by Reducing Oxidative Stress, Inflammation, and Mitochondrial Damage in Mice

Alshehri FS

Drug Design, Development and Therapy 2026, 20:609555

Published Date: 15 June 2026

Review

Recent Advances in the Study of Traditional Chinese Medicine in Reversing Hepatic Fibrosis Through the Regulation of Hepatic Stellate Cells Apoptosis Pathways

Cheng R, Li B

Drug Design, Development and Therapy 2026, 20:602887

Published Date: 15 June 2026

Clinical Trial Report

A Comparison of Tegileridine Fumarate versus Sufentanil on the Quality of Postoperative Recovery After Laparoscopic Sleeve Gastrectomy: A Preliminary Randomized Controlled Trial

Zheng Q, Chen Y, Sui F, Fu Y, Wu Y

Drug Design, Development and Therapy 2026, 20:611241

Published Date: 15 June 2026

Original Research

Anlotinib as Third-Line or Later Therapy in Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma: Real-World Efficacy and Safety Outcomes

Li Y, Li S, Li Y, Pan Z

Drug Design, Development and Therapy 2026, 20:584230

Published Date: 12 June 2026

Review

Protective Effect of Salidroside Against Multiple Organs Ischemia-Reperfusion Injury: New Insights From Common and Specific Pharmacological Mechanisms

Chi X, Zheng S, Guo C, Wang J, Chang Z, Cao X, Jiang L, Zhang Y, Shen W

Drug Design, Development and Therapy 2026, 20:608894

Published Date: 12 June 2026

Review

GLP-1 Receptor Agonists in Neurological Disorders: From Mechanisms to Clinical Translation

Li P, Gao Y, Liu W

Drug Design, Development and Therapy 2026, 20:613616

Published Date: 12 June 2026

Clinical Trial Report

Determination of the ED50 of Tegileridine and Comparison with Fentanyl for Analgesia During Hysteroscopy in Chinese Female Patients: An Exploratory Sequential Dose‑Finding Study

Xu H, Lu F, Wang Y, Ruan X, Xie H, Zhong M

Drug Design, Development and Therapy 2026, 20:608163

Published Date: 12 June 2026

Letter

Effects of Remimazolam Dose and Bolus Injection Rate on Hiccups During Painless Colonoscopy: A Double-Blind Randomized Clinical Trial [Letter]

Wang X, Wang Z

Drug Design, Development and Therapy 2026, 20:627915

Published Date: 11 June 2026

Original Research

Toward Optimized Platinum Therapy: A Risk Prediction Model for Toxicity Based on Platinum Accumulation and Its Impact on Treatment Outcomes

Huang X, Chen C, Zheng J, Lai Y, Yang Y, Zhang Y, Fang L

Drug Design, Development and Therapy 2026, 20:600037

Published Date: 10 June 2026

Original Research

Effect of End-Stage Kidney Disease Factor on the Sedative Effects of Ciprofol

Sun D, Han M, Huang X, Lu D, Zhu B, Zhou D, Hua M, Kang F, Li J

Drug Design, Development and Therapy 2026, 20:601965

Published Date: 10 June 2026

Clinical Trial Report

Isobolographic Analysis of the Interaction Between Remimazolam and Etomidate in General Anesthesia Induction: A Prospective, Sequential Allocation Study Based on the Dixon Up-and-Down Method

Yue W, Huang J, Wang Q, Zheng F, Yin P, Jin Y, Wang Y, Zhang L

Drug Design, Development and Therapy 2026, 20:597710

Published Date: 10 June 2026

Original Research

Identification of Antibacterial Hits Associated with Penicillin-Binding Protein 2 in Escherichia coli Using a Comprehensive Property Spectrum and Fivefold Maximum Drug-Likeness Strategy

Zhu H, Du S, Yang Q, Xu L, Shi W

Drug Design, Development and Therapy 2026, 20:595430

Published Date: 9 June 2026

Clinical Trial Report

Determination of the ED90 for Epidural Hydromorphone and Morphine for Postoperative Pain Using a Biased-Coin Up-and-Down Sequential Design After Elective Cesarean Delivery

Tang X, Liang Y, Hu Y, Li P, Wang J, Wang Y, Xie M

Drug Design, Development and Therapy 2026, 20:588767

Published Date: 9 June 2026

Review

Paeoniflorin as a Promising Therapeutic Candidate in Intestinal Diseases: Experimental Evidence, Mechanistic Insights, and Translational Perspectives

Chang C, Xue J, Xu Z, Hou G

Drug Design, Development and Therapy 2026, 20:617375

Published Date: 9 June 2026

Original Research

Age-Stratified ED95 of Remimazolam Tosilate for Moderate Sedation in Pediatric Patients: A Biased Coin Design Study

Zhu B, Meng W, Pan K, Peng L, Chen X, Wang S, Yang C

Drug Design, Development and Therapy 2026, 20:613464

Published Date: 8 June 2026

Clinical Trial Report

Oliceridine in the Prevention of Catheter-Related Bladder Discomfort: A Single-Center, Randomized, Double-Blind, Prospective Trial

Jiang RJ, Gao S, Yang Z, Bin XY, Cheng L, Liu SX

Drug Design, Development and Therapy 2026, 20:605184

Published Date: 8 June 2026

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