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Drug Design, Development and Therapy


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Bacterial Natural Compounds with Anti-Inflammatory and Immunomodulatory Properties (Mini Review)

Jenab A, Roghanian R, Emtiazi G

Drug Design, Development and Therapy 2020, 14:3787-3801

Published Date: 18 September 2020

Effect of 4-Fluoro-N-(4-Sulfamoylbenzyl) Benzene Sulfonamide on Acquisition and Expression of Nicotine-Induced Behavioral Sensitization and Striatal Adenosine Levels

Ur Rehman N, Abbas M, al-Rashida M, Tokhi A, Arshid MA, Khan MS, Ahmad I, Rauf K

Drug Design, Development and Therapy 2020, 14:3777-3786

Published Date: 17 September 2020

Exosomes Derived from Mesenchymal Stem Cells Protect the Myocardium Against Ischemia/Reperfusion Injury Through Inhibiting Pyroptosis

Tang J, Jin L, Liu Y, Li L, Ma Y, Lu L, Ma J, Ding P, Yang X, Liu J, Yang J

Drug Design, Development and Therapy 2020, 14:3765-3775

Published Date: 16 September 2020

The Potential Effects of Aliskiren on Atrial Remodeling Induced by Chronic Intermittent Hypoxia in Rats

Miao S, Yang Y, Li R, Yin L, Zhang K, Cheng L, Xu X, Wang W, Zhao Z, Li G

Drug Design, Development and Therapy 2020, 14:3755-3764

Published Date: 16 September 2020

Astragaloside IV: An Effective Drug for the Treatment of Cardiovascular Diseases

Tan YQ, Chen HW, Li J

Drug Design, Development and Therapy 2020, 14:3731-3746

Published Date: 15 September 2020

Synthesis and Bioactivity of N-(4-Chlorophenyl)-4-Methoxy-3-(Methylamino) Benzamide as a Potential Anti-HBV Agent

Cui AL, Sun WF, Zhong ZJ, Jin J, Xue ST, Wu S, Li YH, Li ZR

Drug Design, Development and Therapy 2020, 14:3723-3729

Published Date: 15 September 2020

LncRNA SNHG4 Attenuates Inflammatory Responses by Sponging miR-449c-5p and Up-Regulating STAT6 in Microglial During Cerebral Ischemia-Reperfusion Injury

Zhang S, Sun W, Liang Z, Yin X, Ji Z, Chen X, Wei M, Pei L

Drug Design, Development and Therapy 2020, 14:3683-3695

Published Date: 11 September 2020

Emodin Reverses the Epithelial–Mesenchymal Transition of Human Endometrial Stromal Cells by Inhibiting ILK/GSK-3β Pathway

Zheng Q, Wang J, Li W, Chen X, Chen S, Chen L

Drug Design, Development and Therapy 2020, 14:3663-3672

Published Date: 10 September 2020

Knockdown of lncRNA HOXA-AS3 Suppresses the Progression of Atherosclerosis via Sponging miR-455-5p

Chi K, Zhang J, Sun H, Liu Y, Li Y, Yuan T, Zhang F

Drug Design, Development and Therapy 2020, 14:3651-3662

Published Date: 9 September 2020

Research Status and Outlook of PD-1/PD-L1 Inhibitors for Cancer Therapy

Ai L, Chen J, Yan H, He Q, Luo P, Xu Z, Yang X

Drug Design, Development and Therapy 2020, 14:3625-3649

Published Date: 8 September 2020

Enhancing the Butyrylcholinesterase Activity in HEK-293 Cell Line by Dual-Promoter Vector Decorated on Lipofectamine

Mirzaie V, Eslaminejad T, Babaei H, Nematollahi-Mahani SN

Drug Design, Development and Therapy 2020, 14:3589-3599

Published Date: 4 September 2020

Pinocembrin Ameliorates Cognitive Impairment Induced by Vascular Dementia: Contribution of Reelin-dab1 Signaling Pathway

Kang ZC, Wang HG, Yang YL, Zhao XY, Zhou QM, Yang YL, Yang JY, Du GH

Drug Design, Development and Therapy 2020, 14:3577-3587

Published Date: 4 September 2020

Emodin Retarded Renal Fibrosis Through Regulating HGF and TGFβ–Smad Signaling Pathway

Yang F, Deng L, Li J, Chen M, Liu Y, Hu Y, Zhong W

Drug Design, Development and Therapy 2020, 14:3567-3575

Published Date: 3 September 2020

Ketamine Enhances Intranasal Dexmedetomidine-Induced Sedation in Children: A Randomized, Double-Blind Trial

Qian B, Zheng W, Shi J, Chen Z, Guo Y, Yao Y

Drug Design, Development and Therapy 2020, 14:3559-3565

Published Date: 26 August 2020

LncRNA PVT1 Suppresses the Progression of Renal Fibrosis via Inactivation of TGF-β Signaling Pathway

Cao L, Qin P, Zhang J, Qiao H, Shi P, Huo H

Drug Design, Development and Therapy 2020, 14:3547-3557

Published Date: 26 August 2020

Fatostatin in Combination with Tamoxifen Induces Synergistic Inhibition in ER-Positive Breast Cancer

Liu Y, Zhang N, Zhang H, Wang L, Duan Y, Wang X, Chen T, Liang Y, Li Y, Song X, Li C, Han D, Chen B, Zhao W, Yang Q

Drug Design, Development and Therapy 2020, 14:3535-3545

Published Date: 26 August 2020

Bone-Targeting Liposome-Encapsulated Salvianic Acid A Improves Nonunion Healing Through the Regulation of HDAC3-Mediated Endochondral Ossification

Zhou L, Wu H, Gao X, Zheng X, Chen H, Li H, Peng J, Liang W, Wang W, Qiu Z, Udduttula A, Wu K, Li L, Liu Y, Liu Y

Drug Design, Development and Therapy 2020, 14:3519-3533

Published Date: 26 August 2020

Application of Intravenous Lidocaine in Obese Patients Undergoing Painless Colonoscopy: A Prospective, Randomized, Double-Blind, Controlled Study

Li X, Lv X, Jiang Z, Nie X, Wang X, Li T, Zhang L, Liu S

Drug Design, Development and Therapy 2020, 14:3509-3518

Published Date: 27 August 2020

Exosomes-Coated miR-34a Displays Potent Antitumor Activity in Pancreatic Cancer Both in vitro and in vivo

Zuo L, Tao H, Xu H, Li C, Qiao G, Guo M, Cao S, Liu M, Lin X

Drug Design, Development and Therapy 2020, 14:3495-3507

Published Date: 25 August 2020

Video Education Reduces Pain and Anxiety Levels in Cancer Patients Who First Use Fentanyl Transdermal Patch: A Randomized Controlled Trial

Ye Z, Chen J, Zhang Y, Hu X, Xuan Z, Yang S, Mao X, Rao Y

Drug Design, Development and Therapy 2020, 14:3477-3483

Published Date: 25 August 2020

Analysis of the Doxorubicin and Doxorubicinol in the Plasma of Breast Cancer Patients for Monitoring the Toxicity of Doxorubicin

Harahap Y, Ardiningsih P, Corintias Winarti A, Purwanto DJ

Drug Design, Development and Therapy 2020, 14:3469-3475

Published Date: 25 August 2020

Transarterial Chemoembolization Combined with Sorafenib in Patients with BCLC Stage C Hepatocellular Carcinoma

Liu KC, Hao YH, Lv WF, Jia WD, Ji CS, Zhou CZ, Cheng DL, Xu SB, Gao ZG, Su MX, Shi CS

Drug Design, Development and Therapy 2020, 14:3461-3468

Published Date: 25 August 2020

Levonorgestrel Ameliorates Adenomyosis via lncRNA H19/miR-17/TLR4 Pathway

Liang N, Zhang W, Wang H, Shi W, Wang L, Ma L

Drug Design, Development and Therapy 2020, 14:3449-3460

Published Date: 24 August 2020

Sarsasapogenin Suppresses RANKL-Induced Osteoclastogenesis in vitro and Prevents Lipopolysaccharide-Induced Bone Loss in vivo

Peng J, Zhao K, Zhu J, Wang Y, Sun P, Yang Q, Zhang T, Han W, Hu W, Yang W, Ruan J, Qian Y

Drug Design, Development and Therapy 2020, 14:3435-3447

Published Date: 24 August 2020

Efficacy of Sub-Tenon Micro-Perfusion of Cyclophosphamide in Rabbits with Severe Ocular Inflammation

Zhao L, Peng M, Lin W, Tan Q, Khan MA, Lin D

Drug Design, Development and Therapy 2020, 14:3407-3416

Published Date: 20 August 2020

Galangin Improved Non-Alcoholic Fatty Liver Disease in Mice by Promoting Autophagy

Zhang X, Deng Y, Xiang J, Liu H, Zhang J, Liao J, Chen K, Liu B, Liu J, Pu Y

Drug Design, Development and Therapy 2020, 14:3393-3405

Published Date: 19 August 2020

Cinnamaldehyde Treatment of Prostate Cancer-Associated Fibroblasts Prevents Their Inhibitory Effect on T Cells Through Toll-Like Receptor 4

Mei J, Ma J, Xu Y, Wang Y, Hu M, Ma F, Qin Z, Xue R, Tao N

Drug Design, Development and Therapy 2020, 14:3363-3372

Published Date: 18 August 2020

Cannabis Extract CT-921 Has a High Efficacy–Adverse Effect Profile in a Neuropathic Pain Model

Rouhollahi E, MacLeod BA, Barr AM, Puil E

Drug Design, Development and Therapy 2020, 14:3351-3361

Published Date: 17 August 2020

New Benzofuran N-Acylhydrazone Reduces Cardiovascular Dysfunction in Obese Rats by Blocking TNF-Alpha Synthesis

Costa GC, Montagnoli TL, Da Silva JS, Alencar AKN, Reina Gamba LE, Alves BEO, Silva MMC, Trachez MM, Nascimento JHM, Pimentel-Coelho PM, Mendez-Otero R, Lima LM, Barreiro EJ, Sudo RT, Zapata-Sudo G

Drug Design, Development and Therapy 2020, 14:3337-3350

Published Date: 17 August 2020

Beneficial Effect of Genistein on Diabetes-Induced Brain Damage in the ob/ob Mouse Model

Li R, Ding XW, Geetha T, Al-Nakkash L, Broderick TL, Babu JR

Drug Design, Development and Therapy 2020, 14:3325-3336

Published Date: 17 August 2020

Assessment of a New Ginsenoside Rh2 Nanoniosomal Formulation for Enhanced Antitumor Efficacy on Prostate Cancer: An in vitro Study

Zare-Zardini H, Alemi A, Taheri-Kafrani A, Hosseini SA, Soltaninejad H, Hamidieh AA, Haghi Karamallah M, Farrokhifar M, Farrokhifar M

Drug Design, Development and Therapy 2020, 14:3315-3324

Published Date: 13 August 2020

Dual Targeting of Cell Growth and Phagocytosis by Erianin for Human Colorectal Cancer

Sun Y, Li G, Zhou Q, Shao D, Lv J, Zhou J

Drug Design, Development and Therapy 2020, 14:3301-3313

Published Date: 12 August 2020

Therapeutic Drug Monitoring of Rivastigmine and Donepezil Under Consideration of CYP2D6 Genotype-Dependent Metabolism of Donepezil

Ortner M, Stange M, Schneider H, Schröder C, Buerger K, Müller C, Müller-Sarnowski F, Diehl-Schmid J, Förstl H, Grimmer T, Steimer W

Drug Design, Development and Therapy 2020, 14:3251-3262

Published Date: 11 August 2020

Potential Impact of the Multi-Target Drug Approach in the Treatment of Some Complex Diseases

Makhoba XH, Viegas Jr C, Mosa RA, Viegas FPD, Pooe OJ

Drug Design, Development and Therapy 2020, 14:3235-3249

Published Date: 11 August 2020

A Review on Remdesivir: A Possible Promising Agent for the Treatment of COVID-19

Hashemian SM, Farhadi T, Velayati AA

Drug Design, Development and Therapy 2020, 14:3215-3222

Published Date: 6 August 2020

Suppression of c-Met-Overexpressing Tumors by a Novel c-Met/CD3 Bispecific Antibody

Huang L, Xie K, Li H, Wang R, Xu X, Chen K, Gu H, Fang J

Drug Design, Development and Therapy 2020, 14:3201-3214

Published Date: 7 August 2020

Curcumin Protects Against Radiotherapy-Induced Oxidative Injury to the Skin

Shabeeb D, Musa AE, Abd Ali HS, Najafi M

Drug Design, Development and Therapy 2020, 14:3159-3163

Published Date: 5 August 2020

Bioequivalence Study of Amitriptyline Hydrochloride Tablets in Healthy Chinese Volunteers Under Fasting and Fed Conditions

Zhai Y, Wu L, Zheng Y, Wu M, Huang Y, Huang Q, Shentu J, Zhao Q, Liu J

Drug Design, Development and Therapy 2020, 14:3131-3142

Published Date: 4 August 2020

The PPARγ Agonist Rosiglitazone Enhances the Radiosensitivity of Human Pancreatic Cancer Cells

Wang Z, Shen W, Li X, Feng Y, Qian K, Wang G, Gao Y, Xu X, Zhang S, Yue L, Cao J

Drug Design, Development and Therapy 2020, 14:3099-3110

Published Date: 31 July 2020

Nano-Graphene Oxide-supported APTES-Spermine, as Gene Delivery System, for Transfection of pEGFP-p53 into Breast Cancer Cell Lines

Mirzaie V, Ansari M, Nematollahi-Mahani SN, Moballegh Nasery M, Karimi B, Eslaminejad T, Pourshojaei Y

Drug Design, Development and Therapy 2020, 14:3087-3097

Published Date: 30 July 2020

The Climate is Changing for Metered-Dose Inhalers and Action is Needed

Pritchard JN

Drug Design, Development and Therapy 2020, 14:3043-3055

Published Date: 29 July 2020

Chrysin Attenuates the NLRP3 Inflammasome Cascade to Reduce Synovitis and Pain in KOA Rats

Liao T, Ding L, Wu P, Zhang L, Li X, Xu B, Zhang H, Ma Z, Xiao Y, Wang P

Drug Design, Development and Therapy 2020, 14:3015-3027

Published Date: 28 July 2020

Antiviral Agent Therapy Optimization in Special Populations of COVID-19 Patients

Li L, Wang X, Wang R, Hu Y, Jiang S, Lu X

Drug Design, Development and Therapy 2020, 14:3001-3013

Published Date: 28 July 2020

Cordycepin Inhibits Human Gestational Choriocarcinoma Cell Growth by Disrupting Centrosome Homeostasis

Wang CY, Tsai SW, Chien HH, Chen TY, Sheu SY, So EC, Huang BM

Drug Design, Development and Therapy 2020, 14:2987-3000

Published Date: 27 July 2020

Soluplus-Mediated Diosgenin Amorphous Solid Dispersion with High Solubility and High Stability: Development, Characterization and Oral Bioavailability

Liu P, Zhou J, Chang J, Liu X, Xue H, Wang R, Li Z, Li C, Wang J, Liu C

Drug Design, Development and Therapy 2020, 14:2959-2975

Published Date: 27 July 2020

Enhancement of Antitumor Efficacy of Paclitaxel-Loaded PEGylated Liposomes by N,N-Dimethyl Tertiary Amino Moiety in Pancreatic Cancer

Chen Y, Wang L, Luo S, Hu J, Huang X, Li PW, Zhang Y, Wu C, Tian BL

Drug Design, Development and Therapy 2020, 14:2945-2957

Published Date: 23 July 2020

The Effects of Dexmedetomidine and Ketamine on Oxidative Injuries and Histological Changes Following Blunt Chest Trauma

Kartal S, Kip G, Küçük A, Aşçı SS, Erdem Ö, Arslan M, Kavutçu M

Drug Design, Development and Therapy 2020, 14:2937-2943

Published Date: 23 July 2020

Triptolide Inhibits the Proliferation of HaCaT Cells Induced by IL22 via Upregulating miR-181b-5p

He Q, Zhang B, Hu F, Long J, Shi Q, Pi X, Chen H, Li J

Drug Design, Development and Therapy 2020, 14:2927-2935

Published Date: 22 July 2020

Film-Forming Sprays for Topical Drug Delivery

Umar AK, Butarbutar M, Sriwidodo S, Wathoni N

Drug Design, Development and Therapy 2020, 14:2909-2925

Published Date: 22 July 2020

The Anti-Inflammatory Effect of Different Doses of Aliskiren in Rat Models of Inflammation

Aziz TA, Kareem AA, Othman HH, Ahmed ZA

Drug Design, Development and Therapy 2020, 14:2841-2851

Published Date: 20 July 2020

Lentinan Inhibits AGE-Induced Inflammation and the Expression of Matrix-Degrading Enzymes in Human Chondrocytes

Zhang Z, Zha Z, Zhao Z, Liu W, Li W

Drug Design, Development and Therapy 2020, 14:2819-2829

Published Date: 17 July 2020

Cordycepin Alleviates Anterior Cruciate Ligament Transection (ACLT)-Induced Knee Osteoarthritis Through Regulating TGF-β Activity and Autophagy

Tao XM, Liu PF, Gu HY, Lian DB, Gao L, Tao WW, Yan D, Zhao B

Drug Design, Development and Therapy 2020, 14:2809-2817

Published Date: 17 July 2020

A Synthetic Peptide 2Abz23S29 Reduces Bacterial Titer and Induces Pro-Inflammatory Cytokines in a Murine Model of Urinary Tract Infection

Moazzezy N, Asadi Karam MR, Rafati S, Bouzari S, Oloomi M

Drug Design, Development and Therapy 2020, 14:2797-2807

Published Date: 17 July 2020

Promising Swellable Floating Bupropion Tablets: Formulation, in vitro/in vivo Evaluation and Comparative Pharmacokinetic Study in Human Volunteers

Teaima M, Abdel Hamid MM, Shoman NA, Jasti BR, El-Nabarawi MA

Drug Design, Development and Therapy 2020, 14:2741-2757

Published Date: 14 July 2020

Network Pharmacology-Based Prediction and Verification of the Active Ingredients and Potential Targets of Zuojinwan for Treating Colorectal Cancer

Huang S, Zhang Z, Li W, Kong F, Yi P, Huang J, Mao D, Peng W, Zhang S

Drug Design, Development and Therapy 2020, 14:2725-2740

Published Date: 14 July 2020

The Regulating Mechanism of Chrysophanol on Protein Level of CaM-CaMKIV to Protect PC12 Cells Against Aβ25-35-Induced Damage

Ye T, Gao HW, Xuan WT, Ye S, Zhou P, Li XQ, Wang Y, Song H, Liu YY, Cai B

Drug Design, Development and Therapy 2020, 14:2715-2723

Published Date: 13 July 2020

Ribbon Synapses and Hearing Impairment in Mice After in utero Sevoflurane Exposure

Yuan X, Liu H, Li Y, Li W, Yu H, Shen X

Drug Design, Development and Therapy 2020, 14:2685-2693

Published Date: 8 July 2020

Anti-Breast Cancer Effect of 2-Dodecyl-6-Methoxycyclohexa-2,5-Diene-1,4-Dione in vivo and in vitro Through MAPK Signaling Pathway

Zhou X, Wu X, Qin L, Lu S, Zhang H, Wei J, Chen L, Jiang L, Wu Y, Chen C, Huang R

Drug Design, Development and Therapy 2020, 14:2667-2684

Published Date: 7 July 2020

N-Acetyl-l-Leucine-Polyethyleneimine-Mediated Delivery of CpG Oligodeoxynucleotides 2006 Inhibits RAW264.7 Cell Osteoclastogenesis

Wang H, Yu W, Li H, Zheng Y, Chen Z, Lin H, Shen Y

Drug Design, Development and Therapy 2020, 14:2657-2665

Published Date: 7 July 2020

Evaluation of Bioequivalency and Pharmacokinetic Parameters for Two Formulations of Glimepiride 1-mg in Chinese Subjects

Ju G, Yan K, Xu Y, Chen S, Zheng Z, Qiu W

Drug Design, Development and Therapy 2020, 14:2637-2644

Published Date: 6 July 2020

The Expression and Therapeutic Potential of Checkpoint Kinase 2 in Laryngeal Squamous Cell Carcinoma

Tian Y, Wang Y, Xu S, Guan C, Zhang Q, Li W

Drug Design, Development and Therapy 2020, 14:2613-2622

Published Date: 6 July 2020

Structural Insight into the Mechanism of 4-Aminoquinolines Selectivity for the alpha2A-Adrenoceptor

Li Z, Li J, Liu L, Deng W, Liu Q, Liu R, Zhang W, He Z, Fan L, Yang Y, Duan Y, Hou H, Wang X, Yang Z, Wang X, Chen S, Wang Y, Huang N, Chen J

Drug Design, Development and Therapy 2020, 14:2585-2594

Published Date: 3 July 2020

Melatonin Alleviates Neuronal Damage After Intracerebral Hemorrhage in Hyperglycemic Rats

Liang F, Wang J, Zhu X, Wang Z, Zheng J, Sun Z, Xu S, Zhang J, Zhou J, Shi L

Drug Design, Development and Therapy 2020, 14:2573-2584

Published Date: 2 July 2020

Effects of Calcium and Annatto Tocotrienol Supplementation on Bone Loss Induced by Pantoprazole in Male Rats

Chin KY, Thong BKS, Kamalulloh RF, Mohamad NV, Wong SK, Mohd Arlamsyah A, Triliana R, Soelaiman IN

Drug Design, Development and Therapy 2020, 14:2561-2572

Published Date: 2 July 2020

Impact of Administration Time and Kv7 Subchannels on the Cardioprotective Efficacy of Kv7 Channel Inhibition

Hansen J, Johnsen J, Nielsen JM, Sørensen CB, Elkjær CC, Jespersen NR, Bøtker HE

Drug Design, Development and Therapy 2020, 14:2549-2560

Published Date: 2 July 2020

Synthesis and Biological Evaluations of Monocarbonyl Curcumin Inspired Pyrazole Analogues as Potential Anti-Colon Cancer Agent

Min Z, Zhu Y, Hong X, Yu Z, Ye M, Yuan Q, Hu X

Drug Design, Development and Therapy 2020, 14:2517-2534

Published Date: 29 June 2020

Management of Pediatric Systemic Lupus Erythematosus: Focus on Belimumab

Guzman M, Hui-Yuen JS

Drug Design, Development and Therapy 2020, 14:2503-2513

Published Date: 25 June 2020

Remogliflozin Etabonate in the Treatment of Type 2 Diabetes: Design, Development, and Place in Therapy

Mohan V, Mithal A, Joshi SR, Aravind SR, Chowdhury S

Drug Design, Development and Therapy 2020, 14:2487-2501

Published Date: 24 June 2020

Are Laboratory Parameter (Biomarker) Values Similar to the Healthy Volunteer Reference Range in Individuals with Diabetes

Brott DA, Goodman MJ, Hermann RP, Anderson I, Kiazand A

Drug Design, Development and Therapy 2020, 14:2473-2486

Published Date: 24 June 2020

Berberine Attenuates Arterial Plaque Formation in Atherosclerotic Rats with Damp-Heat Syndrome via Regulating Autophagy

Ke X, Huang Y, Li L, Xin F, Xu L, Zhang Y, Zeng Z, Lin F, Song Y

Drug Design, Development and Therapy 2020, 14:2449-2460

Published Date: 23 June 2020

Artificial Neural Network (ANN) Approach to Predict an Optimized pH-Dependent Mesalamine Matrix Tablet

Khan AM, Hanif M, Bukhari NI, Shamim R, Rasool F, Rasul S, Shafique S

Drug Design, Development and Therapy 2020, 14:2435-2448

Published Date: 22 June 2020

Aprepitant Sensitizes Acute Myeloid Leukemia Cells to the Cytotoxic Effects of Cytosine Arabinoside in vitro and in vivo

Wu H, Cheng X, Huang F, Shao G, Meng Y, Wang L, Wang T, Jia X, Yang T, Wang X, Fu C

Drug Design, Development and Therapy 2020, 14:2413-2422

Published Date: 18 June 2020

Sugar Codes Conjugated Alginate: An Innovative Platform to Make a Strategic Breakthrough in Simultaneous Prophylaxis of GERD and Helicobacter pylori Infection

Moayedi S, Yadegar A, Balalaie S, Yarmohammadi M, Zali MR, Suzuki H, Fricker G, Haririan I

Drug Design, Development and Therapy 2020, 14:2405-2412

Published Date: 17 June 2020

Metformin Decreases Insulin Resistance in Type 1 Diabetes Through Regulating p53 and RAP2A in vitro and in vivo

Ren GF, Xiao LL, Ma XJ, Yan YS, Jiao PF

Drug Design, Development and Therapy 2020, 14:2381-2392

Published Date: 17 June 2020

Activation of GPR40 Suppresses AGE-Induced Reduction of Type II Collagen and Aggrecan in Human SW1353 Chondrocytes

Gu J, Lin H, Zhang Y, Xu T, Wang T, Xue X, Zhang W, Liu H

Drug Design, Development and Therapy 2020, 14:2371-2379

Published Date: 15 June 2020

A Gastric Cancer Peptide GX1-Modified Nano-Lipid Carriers Encapsulating Paclitaxel: Design and Evaluation of Anti-Tumor Activity

Jian Y, Zhao M, Cao J, Fan T, Bu W, Yang Y, Li W, Zhang W, Qiao Y, Wang J, Wen A

Drug Design, Development and Therapy 2020, 14:2355-2370

Published Date: 12 June 2020

In vitro and in vivo Anti-Tumor Effects of Pan-HER Inhibitor Varlitinib on Cholangiocarcinoma Cell Lines

Dokduang H, Jamnongkarn W, Promraksa B, Suksawat M, Padthaisong S, Thanee M, Phetcharaburanin J, Namwat N, Sangkhamanon S, Titapun A, Khuntikeo N, Klanrit P, Loilome W

Drug Design, Development and Therapy 2020, 14:2319-2334

Published Date: 11 June 2020

Scalable in silico Simulation of Transdermal Drug Permeability: Application of BIOiSIM Platform

Maharao N, Antontsev V, Hou H, Walsh J, Varshney J

Drug Design, Development and Therapy 2020, 14:2307-2317

Published Date: 11 June 2020

Nimodipine Improves Cognitive Impairment After Subarachnoid Hemorrhage in Rats Through IncRNA NEAT1/miR-27a/MAPT Axis

Li JW, Ren SH, Ren JR, Zhen ZG, Li LR, Hao XD, Ji HM

Drug Design, Development and Therapy 2020, 14:2295-2306

Published Date: 10 June 2020

Combination Therapy of Lung Cancer Using Layer-by-Layer Cisplatin Prodrug and Curcumin Co-Encapsulated Nanomedicine

Hong Y, Che S, Hui B, Wang X, Zhang X, Ma H

Drug Design, Development and Therapy 2020, 14:2263-2274

Published Date: 9 June 2020

Combination Chemotherapy of Lung Cancer – Co-Delivery of Docetaxel Prodrug and Cisplatin Using Aptamer-Decorated Lipid–Polymer Hybrid Nanoparticles

Wu R, Zhang Z, Wang B, Chen G, Zhang Y, Deng H, Tang Z, Mao J, Wang L

Drug Design, Development and Therapy 2020, 14:2249-2261

Published Date: 9 June 2020

Parenteral Sustained Release Lipid Phase-Transition System of Ziprasidone: Fabrication and Evaluation for Schizophrenia Therapy

Khan UA, Parveen U, Hasan N, Ahmed MZ, Saad S, Ahmad FJ, Jain GK

Drug Design, Development and Therapy 2020, 14:2237-2247

Published Date: 9 June 2020

Treatment with a PPAR-γ Agonist Protects Against Hyperuricemic Nephropathy in a Rat Model

Wang X, Deng J, Xiong C, Chen H, Zhou Q, Xia Y, Shao X, Zou H

Drug Design, Development and Therapy 2020, 14:2221-2233

Published Date: 8 June 2020

Gastro-Protective Effects of Calycosin Against Precancerous Lesions of Gastric Carcinoma in Rats

Li D, Zhao L, Li Y, Kang X, Zhang S

Drug Design, Development and Therapy 2020, 14:2207-2219

Published Date: 9 June 2020

Effects of Voriconazole on the Pharmacokinetics of Vonoprazan in Rats

Shen J, Wang B, Wang S, Chen F, Meng D, Jiang H, Zhou Y, Geng P, Zhou Q, Liu B

Drug Design, Development and Therapy 2020, 14:2199-2206

Published Date: 4 June 2020

Development of 13-Cys-BBR as an Agent Having Dual Action of Anti-Thrombosis and Anti-Inflammation

Li G, Wang T, Zhang X, Zhao S, Wang Y, Wu J, Peng S, Zhao M

Drug Design, Development and Therapy 2020, 14:2187-2197

Published Date: 3 June 2020

Comparative Cholinesterase, α-Glucosidase Inhibitory, Antioxidant, Molecular Docking, and Kinetic Studies on Potent Succinimide Derivatives

Ahmad A, Ullah F, Sadiq A, Ayaz M, Saeed Jan M, Shahid M, Wadood A, Mahmood F, Rashid U, Ullah R, Sahibzada MUK, Alqahtani AS, Mahmood HM

Drug Design, Development and Therapy 2020, 14:2165-2178

Published Date: 3 June 2020

Analysis of Renal and Cardiac Outcomes in Male Participants in the Fabry Outcome Survey Starting Agalsidase Alfa Enzyme Replacement Therapy Before and After 18 Years of Age

Parini R, Pintos-Morell G, Hennermann JB, Hsu TR, Karabul N, Kalampoki V, Gurevich A, Ramaswami U

Drug Design, Development and Therapy 2020, 14:2149-2158

Published Date: 3 June 2020

Network Pharmacology and Experimental Evidence Reveal Dioscin Suppresses Proliferation, Invasion, and EMT via AKT/GSK3b/mTOR Signaling in Lung Adenocarcinoma

Mao W, Yin H, Chen W, Zhao T, Wu S, Jin H, Du B, Tan Y, Zhang R, He Y

Drug Design, Development and Therapy 2020, 14:2135-2147

Published Date: 28 May 2020

Effect of Lactoferrin Protein on Red Blood Cells and Macrophages: Mechanism of Parasite–Host Interaction [Corrigendum]

Anand N, Kanwar R, Dubey M, Vahishta RK, Sehgal R, Verma A, Kanwar J

Drug Design, Development and Therapy 2020, 14:2123-2124

Published Date: 28 May 2020

A Pharmacokinetic Drug Interaction Between Fimasartan and Linagliptin in Healthy Volunteers

Kang WY, Lee HW, Gwon MR, Cho S, Shim WS, Lee KT, Yang DH, Seong SJ, Yoon YR

Drug Design, Development and Therapy 2020, 14:2101-2111

Published Date: 26 May 2020

Dihydroartemisinin Inhibits the Proliferation of Leukemia Cells K562 by Suppressing PKM2 and GLUT1 Mediated Aerobic Glycolysis

Gao P, Shen S, Li X, Liu D, Meng Y, Liu Y, Zhu Y, Zhang J, Luo P, Gu L

Drug Design, Development and Therapy 2020, 14:2091-2100

Published Date: 27 May 2020

Resveratrol Exerts Anti-Osteoarthritic Effect by Inhibiting TLR4/NF-κB Signaling Pathway via the TLR4/Akt/FoxO1 Axis in IL-1β-Stimulated SW1353 Cells

Xu X, Liu X, Yang Y, He J, Jiang M, Huang Y, Liu X, Liu L, Gu H

Drug Design, Development and Therapy 2020, 14:2079-2090

Published Date: 26 May 2020

Synthesis and Biological Activity of Piperine Derivatives as Potential PPARγ Agonists

Wang Y, Yao Y, Liu J, Wu L, Liu T, Cui J, Lee DYW

Drug Design, Development and Therapy 2020, 14:2069-2078

Published Date: 26 May 2020

Glycine Improves Ischemic Stroke Through miR-19a-3p/AMPK/GSK-3β/HO-1 Pathway

Chen ZJ, Zhao XS, Fan TP, Qi HX, Li D

Drug Design, Development and Therapy 2020, 14:2021-2031

Published Date: 25 May 2020

A Triple Combination of Metformin, Acetylsalicylic Acid, and Oseltamivir Phosphate Impacts Tumour Spheroid Viability and Upends Chemoresistance in Triple-Negative Breast Cancer

Sambi M, Samuel V, Qorri B, Haq S, Burov SV, Markvicheva E, Harless W, Szewczuk MR

Drug Design, Development and Therapy 2020, 14:1995-2019

Published Date: 25 May 2020

Effects of Apatinib on the Pharmacokinetics of Nifedipine and Warfarin in Patients with Advanced Solid Tumors

Zhu YT, Teng Z, Zhang YF, Li W, Guo LX, Liu YP, Qu XJ, Wang QR, Mao SY, Chen XY, Zhong DF

Drug Design, Development and Therapy 2020, 14:1963-1970

Published Date: 20 May 2020

Alleviation of Liver Dysfunction, Oxidative Stress and Inflammation Underlies the Protective Effect of Ferulic Acid in Methotrexate-Induced Hepatotoxicity

Roghani M, Kalantari H, Khodayar MJ, Khorsandi L, Kalantar M, Goudarzi M, Kalantar H

Drug Design, Development and Therapy 2020, 14:1933-1941

Published Date: 20 May 2020

Inhibitory Effect of Lygodium Root on the Cytochrome P450 3A Enzyme in vitro and in vivo

Zhou Y, Hua A, Zhou Q, Geng P, Chen F, Yan L, Wang S, Wen C

Drug Design, Development and Therapy 2020, 14:1909-1919

Published Date: 19 May 2020

Applying Different Techniques to Improve the Bioavailability of Candesartan Cilexetil Antihypertensive Drug

Aly UF, Sarhan HA, Ali TFS, Sharkawy HAEB

Drug Design, Development and Therapy 2020, 14:1851-1865

Published Date: 14 May 2020

Pharmacokinetics and Metabolism Research of Shenkang Injection in Rats Based on UHPLC-MS/MS and UHPLC-Q-Orbitrap HRMS

Jiang X, Zhou L, Zuo L, Wang X, Shi Y, Du X, Zhang J, Liu L, Li Z, Xue L, Liu X, Sun Z

Drug Design, Development and Therapy 2020, 14:1837-1850

Published Date: 13 May 2020

Berberine Induces Autophagic Cell Death in Acute Lymphoblastic Leukemia by Inactivating AKT/mTORC1 Signaling

Liu J, Liu P, Xu T, Chen Z, Kong H, Chu W, Wang Y, Liu Y

Drug Design, Development and Therapy 2020, 14:1813-1823

Published Date: 12 May 2020

Pranlukast Antagonizes CD49f and Reduces Stemness in Triple-Negative Breast Cancer Cells

Velázquez-Quesada I, Ruiz-Moreno AJ, Casique-Aguirre D, Aguirre-Alvarado C, Cortés-Mendoza F, de la Fuente-Granada M, García-Pérez C, Pérez-Tapia SM, González-Arenas A, Segura-Cabrera A, Velasco-Velázquez MA

Drug Design, Development and Therapy 2020, 14:1799-1811

Published Date: 12 May 2020

Virtual Screening and Optimization of Novel mTOR Inhibitors for Radiosensitization of Hepatocellular Carcinoma

Feng YQ, Gu SX, Chen YS, Gao XD, Ren YX, Chen JC, Lu YY, Zhang H, Cao S

Drug Design, Development and Therapy 2020, 14:1779-1798

Published Date: 8 May 2020

Investigation of the Inhibitory Effect of Simvastatin on the Metabolism of Lidocaine Both in vitro and in vivo

Wang Y, Ou-yang Q, Huang W, Huang H, Zhuang X, Lin Q, Zeng D

Drug Design, Development and Therapy 2020, 14:1739-1747

Published Date: 6 May 2020

Pharmacokinetic Evaluation by Modeling and Simulation Analysis of a Donepezil Patch Formulation in Healthy Male Volunteers

Yoon SK, Bae KS, Hong DH, Kim SS, Choi YK, Lim HS

Drug Design, Development and Therapy 2020, 14:1729-1737

Published Date: 5 May 2020

High ACTN1 Is Associated with Poor Prognosis, and ACTN1 Silencing Suppresses Cell Proliferation and Metastasis in Oral Squamous Cell Carcinoma

Xie G, Zhao L, Chen Q, Tang D, Chen Q, Lu H, Cai J, Chen Z

Drug Design, Development and Therapy 2020, 14:1717-1727

Published Date: 5 May 2020

Pexidartinib, a Novel Small Molecule CSF-1R Inhibitor in Use for Tenosynovial Giant Cell Tumor: A Systematic Review of Pre-Clinical and Clinical Development

Benner B, Good L, Quiroga D, Schultz TE, Kassem M, Carson WE, Cherian MA, Sardesai S, Wesolowski R

Drug Design, Development and Therapy 2020, 14:1693-1704

Published Date: 4 May 2020

Pharmacokinetic-Based Drug–Drug Interactions with Anaplastic Lymphoma Kinase Inhibitors: A Review

Zhao D, Chen J, Chu M, Long X, Wang J

Drug Design, Development and Therapy 2020, 14:1663-1681

Published Date: 30 April 2020

Astaxanthin Attenuates Neuroinflammation in Status Epilepticus Rats by Regulating the ATP-P2X7R Signal

Wang M, Deng X, Xie Y, Chen Y

Drug Design, Development and Therapy 2020, 14:1651-1662

Published Date: 30 April 2020

Arsenic Disulfide Promoted Hypomethylation by Increasing DNA Methyltransferases Expression in Myelodysplastic Syndrome

Zhou QB, Liu ZT, Wang HZ, Guo XQ, Xu YG, Hu XM

Drug Design, Development and Therapy 2020, 14:1641-1650

Published Date: 30 April 2020

Effect of Eriodictyol on Collagen-Induced Arthritis in Rats by Akt/HIF-1α Pathway

Lei Z, Ouyang L, Gong Y, Wang Z, Yu B

Drug Design, Development and Therapy 2020, 14:1633-1639

Published Date: 29 April 2020

Bone Marrow Mesenchymal Stem Cell-Derived Exosomes Improves Spinal Cord Function After Injury in Rats by Activating Autophagy

Gu J, Jin ZS, Wang CM, Yan XF, Mao YQ, Chen S

Drug Design, Development and Therapy 2020, 14:1621-1631

Published Date: 29 April 2020

In vitro Multistage Malaria Transmission Blocking Activity of Selected Malaria Box Compounds

Malebo HM, D'Alessandro S, Ebstie YA, Sorè H, Tenoh Guedoung AR, Katani SJ, Parapini S, Taramelli D, Habluetzel A

Drug Design, Development and Therapy 2020, 14:1593-1607

Published Date: 28 April 2020

Metformin Inhibits Propofol-Induced Apoptosis of Mouse Hippocampal Neurons HT-22 Through Downregulating Cav-1

Ge J, Huang Y, Zhang Y, Liu L, Gu T, Liu X, Yao L, Cai M, Sun J, Song J

Drug Design, Development and Therapy 2020, 14:1561-1569

Published Date: 21 April 2020

ACE2 Attenuates Epithelial-Mesenchymal Transition in MLE-12 Cells Induced by Silica

Li S, Li Y, Xu H, Wei Z, Yang Y, Jin F, Zhang M, Wang C, Song W, Huo J, Zhao J, Yang X, Yang F

Drug Design, Development and Therapy 2020, 14:1547-1559

Published Date: 21 April 2020

Selection and Characterization of a Novel DNA Aptamer, Apt-07S Specific to Hepatocellular Carcinoma Cells

Yu XX, Ge KL, Liu N, Zhang JY, Xue ML, Ge YL

Drug Design, Development and Therapy 2020, 14:1535-1545

Published Date: 20 April 2020

Optimal Approach and Strategies to Strengthen Pharmacovigilance in Sub-Saharan Africa: A Cohort Study of Patients Treated with First-Line Artemisinin-Based Combination Therapies in the Nanoro Health and Demographic Surveillance System, Burkina Faso

Rouamba T, Sondo P, Derra K, Nakanabo-Diallo S, Bihoun B, Rouamba E, Tarnagda Z, Kazienga A, Valea I, Sorgho H, Pagnoni F, Samadoulougou-Kirakoya F, Tinto H

Drug Design, Development and Therapy 2020, 14:1507-1521

Published Date: 16 April 2020

Isoliquiritigenin Attenuates UUO-Induced Renal Inflammation and Fibrosis by Inhibiting Mincle/Syk/NF-Kappa B Signaling Pathway

Liao Y, Tan R, Li J, Liu T, Zhong X, Yan Y, Yang J, Lin X, Fan J, Wang L

Drug Design, Development and Therapy 2020, 14:1455-1468

Published Date: 14 April 2020

Salidroside Alleviates Cartilage Degeneration Through NF-κB Pathway in Osteoarthritis Rats

Gao H, Peng L, Li C, Ji Q, Li P

Drug Design, Development and Therapy 2020, 14:1445-1454

Published Date: 14 April 2020

Metabolite Profiling in Anticancer Drug Development: A Systematic Review

Muhamad N, Na-Bangchang K

Drug Design, Development and Therapy 2020, 14:1401-1444

Published Date: 9 April 2020

One-Pot Synthesis of Novel Thiazoles as Potential Anti-Cancer Agents

Sayed AR, Gomha SM, Taher EA, Muhammad ZA, El-Seedi HR, Gaber HM, Ahmed MM

Drug Design, Development and Therapy 2020, 14:1363-1375

Published Date: 3 April 2020

Proniosomal Telmisartan Tablets: Formulation, in vitro Evaluation and in vivo Comparative Pharmacokinetic Study in Rabbits

Teaima MH, Yasser M, El-Nabarawi MA, Helal DA

Drug Design, Development and Therapy 2020, 14:1319-1331

Published Date: 31 March 2020

Leishmania donovani Growth Inhibitors from Pathogen Box Compounds of Medicine for Malaria Venture

Tadele M, Abay SM, Makonnen E, Hailu A

Drug Design, Development and Therapy 2020, 14:1307-1317

Published Date: 31 March 2020

Alginate Suppresses Liver Fibrosis Through the Inhibition of Nuclear Factor-κB Signaling

Xia Z, Ding L, Zheng J, Xu Y, Jin W, Sheng X, Wu J

Drug Design, Development and Therapy 2020, 14:1295-1305

Published Date: 31 March 2020

Diterpene Ginkgolides Exert an Antidepressant Effect Through the NT3-TrkA and Ras-MAPK Pathways

Wang T, Bai S, Wang W, Chen Z, Chen J, Liang Z, Qi X, Shen H, Xie P

Drug Design, Development and Therapy 2020, 14:1279-1294

Published Date: 31 March 2020

Growth Factor Gene-Modified Mesenchymal Stem Cells in Tissue Regeneration

Nie WB, Zhang D, Wang LS

Drug Design, Development and Therapy 2020, 14:1241-1256

Published Date: 26 March 2020

Morusin Ameliorates IL-1β-Induced Chondrocyte Inflammation and Osteoarthritis via NF-κB Signal Pathway

Jia Y, He W, Zhang H, He L, Wang Y, Zhang T, Peng J, Sun P, Qian Y

Drug Design, Development and Therapy 2020, 14:1227-1240

Published Date: 26 March 2020

Comparison of Pharmacokinetics of Aprepitant in Healthy Chinese and Caucasian Subjects

Yang MJ, Xu HR, Li H, Chen WL, Yuan F, Li XN

Drug Design, Development and Therapy 2020, 14:1219-1226

Published Date: 24 March 2020

Miconazole Contributes to NRF2 Activation by Noncanonical P62-KEAP1 Pathway in Bladder Cancer Cells

Tsai TF, Chen PC, Lin YC, Chou KY, Chen HE, Ho CY, Lin JF, Hwang TIS

Drug Design, Development and Therapy 2020, 14:1209-1218

Published Date: 24 March 2020

Paeoniflorin Ameliorates Chronic Hypoxia/SU5416-Induced Pulmonary Arterial Hypertension by Inhibiting Endothelial-to-Mesenchymal Transition

Yu M, Peng L, Liu P, Yang M, Zhou H, Ding Y, Wang J, Huang W, Tan Q, Wang Y, Xie W, Kong H, Wang H

Drug Design, Development and Therapy 2020, 14:1191-1202

Published Date: 19 March 2020

A First-in-Human Dose Finding Study of Camrelizumab in Patients with Advanced or Metastatic Cancer in Australia

Lickliter JD, Gan HK, Voskoboynik M, Arulananda S, Gao B, Nagrial A, Grimison P, Harrison M, Zou J, Zhang L, Luo S, Lahn M, Kallender H, Mannucci A, Somma C, Woods K, Behren A, Fernandez-Penas P, Millward M, Meniawy T

Drug Design, Development and Therapy 2020, 14:1177-1189

Published Date: 18 March 2020

Hyaluronic Acid Capped, Irinotecan and Gene Co-Loaded Lipid-Polymer Hybrid Nanocarrier-Based Combination Therapy Platform for Colorectal Cancer

Wang Z, Zang A, Wei Y, An L, Hong D, Shi Y, Zhang J, Su S, Fang G

Drug Design, Development and Therapy 2020, 14:1095-1105

Published Date: 12 March 2020

Review on the Structures and Activities of Transthyretin Amyloidogenesis Inhibitors

Guo X, Liu Z, Zheng Y, Li Y, Li L, Liu H, Chen Z, Wu L

Drug Design, Development and Therapy 2020, 14:1057-1081

Published Date: 10 March 2020

KLF6 Induces Apoptosis in Human Lens Epithelial Cells Through the ATF4-ATF3-CHOP Axis

Tian F, Zhao J, Bu S, Teng H, Yang J, Zhang X, Li X, Dong L

Drug Design, Development and Therapy 2020, 14:1041-1055

Published Date: 9 March 2020

In silico Design and Synthesis of Tetrahydropyrimidinones and Tetrahydropyrimidinethiones as Potential Thymidylate Kinase Inhibitors Exerting Anti-TB Activity Against Mycobacterium tuberculosis

Venugopala KN, Tratrat C, Pillay M, Chandrashekharappa S, Al-Attraqchi OHA, Aldhubiab BE, Attimarad M, Alwassil OI, Nair AB, Sreeharsha N, Venugopala R, Morsy MA, Haroun M, Kumalo HM, Odhav B, Mlisana K

Drug Design, Development and Therapy 2020, 14:1027-1039

Published Date: 9 March 2020

Characterization and Evaluation of Antioxidant Activity of Aloe schelpei Reynolds

Teka T, Kassahun H

Drug Design, Development and Therapy 2020, 14:1003-1008

Published Date: 5 March 2020

Bisdemethoxycurcumin Inhibits Hepatocellular Carcinoma Proliferation Through Akt Inactivation via CYLD-Mediated Deubiquitination

Qiu C, Liu K, Zhang S, Gao S, Chen W, Li D, Huang Y

Drug Design, Development and Therapy 2020, 14:993-1001

Published Date: 5 March 2020

Study on the Formation of Antihypertensive Twin Drugs by Caffeic Acid and Ferulic Acid with Telmisartan

Li P, Peng Y, Ma Q, Li Z, Zhang X

Drug Design, Development and Therapy 2020, 14:977-992

Published Date: 5 March 2020

Perindopril in Breast Milk and Determination of Breastfed Infant Exposure: A Prospective Observational Study

Leggett C, Lwin EMP, Ritchie U, Song Y, Gerber JP, Turner S, Hague WM, Stark M, Upton R, Garg S

Drug Design, Development and Therapy 2020, 14:961-967

Published Date: 2 March 2020

Finasteride and Its Potential for the Treatment of Female Pattern Hair Loss: Evidence to Date

Iamsumang W, Leerunyakul K, Suchonwanit P

Drug Design, Development and Therapy 2020, 14:951-959

Published Date: 2 March 2020

The Traditional Chinese Medicine Compound, GRS, Alleviates Blood–Brain Barrier Dysfunction

Zhang Y, Hu Y, Li M, Wang J, Guo G, Li F, Yu B, Kou J

Drug Design, Development and Therapy 2020, 14:933-947

Published Date: 28 February 2020

Oxymatrine Liposomes for Intervertebral Disc Treatment: Formulation, in vitro and vivo Assessments

Wang H, Ding Y, Zhang W, Wei K, Pei Y, Zou C, Zhang C, Ding J, Fang H, Tan S

Drug Design, Development and Therapy 2020, 14:921-931

Published Date: 28 February 2020

Pleiotropic Anticancer Properties of Scorpion Venom Peptides: Rhopalurus princeps Venom as an Anticancer Agent

Mikaelian AG, Traboulay E, Zhang XM, Yeritsyan E, Pedersen PL, Ko YH, Matalka KZ

Drug Design, Development and Therapy 2020, 14:881-893

Published Date: 27 February 2020

The Advantages of Levodopa-Carbidopa Intestinal Gel for Patients with Advanced Parkinson’s Disease: A Systematic Review

Zhang XR, Jiang ZY, Zhang ZR, Chen HJ, Wu K, He JC, Xie CL

Drug Design, Development and Therapy 2020, 14:845-854

Published Date: 26 February 2020

Metalloprotoporphyrin Inhibition of HCV NS3-4A Protease: Structure–Activity Relationships

Hu K, Zhu Z, Mathahs MM, Tran H, Bommer J, Testa CA, Schmidt WN

Drug Design, Development and Therapy 2020, 14:757-771

Published Date: 24 February 2020

NVP-BSK805, an Inhibitor of JAK2 Kinase, Significantly Enhances the Radiosensitivity of Esophageal Squamous Cell Carcinoma in vitro and in vivo

Hua Y, Wang W, Zheng X, Yang L, Wu H, Hu Z, Li Y, Yue J, Jiang Z, Zhang X, Hou Q, Wu S

Drug Design, Development and Therapy 2020, 14:745-755

Published Date: 24 February 2020

Synthesis, Characterization, and Pharmacodynamics Study of Enrofloxacin Mesylate

Pei L, Yang W, Fu J, Liu M, Zhang T, Li D, Huang R, Zhang L, Peng G, Shu G, Yuan Z, Lin J, Zhang W, Zhong Z, Zhao L, Fu H

Drug Design, Development and Therapy 2020, 14:715-730

Published Date: 24 February 2020

Anti-Inflammatory Activity of Sanjie Zhentong Capsule Assessed By Network Pharmacology Analysis of Adenomyosis Treatment 

Du L, Du DH, Chen B, Ding Y, Zhang T, Xiao W

Drug Design, Development and Therapy 2020, 14:697-713

Published Date: 20 February 2020

Colon Targeting of Naringin for Enhanced Cytoprotection Against Indomethacin-Induced Colitis in Rabbits

El Naggar EE, Mohamed EA, Borg TM, El-Sheakh AR, Hamed MF

Drug Design, Development and Therapy 2020, 14:677-696

Published Date: 19 February 2020

Impacts of CYP2C19 Polymorphism and Clopidogrel Dosing on in-Stent Restenosis: A Retrospective Cohort Study in Chinese Patients

Zhang M, Wang J, Zhang Y, Zhang P, Jia Z, Ren M, Jia X, Ma L, Gao M, Hou Y

Drug Design, Development and Therapy 2020, 14:669-676

Published Date: 19 February 2020

A Comparative Study of Inhaled Nitric Oxide and an Intravenously Administered Nitric Oxide Donor in Acute Pulmonary Hypertension

Stene Hurtsén A, Zorikhin Nilsson I, Dogan EM, Nilsson KF

Drug Design, Development and Therapy 2020, 14:635-645

Published Date: 17 February 2020

Hydrogen Sulfide Protects Against High Glucose-Induced Human Umbilical Vein Endothelial Cell Injury Through Activating PI3K/Akt/eNOS Pathway

Lin F, Yang Y, Wei S, Huang X, Peng Z, Ke X, Zeng Z, Song Y

Drug Design, Development and Therapy 2020, 14:621-633

Published Date: 14 February 2020

Pharmacokinetics and Tolerability of Single and Multiple Intravenous Doses of Cefotetan Disodium in Healthy Chinese Volunteers

Liu J, Zhai Y, Wu L, Wu G, Zheng Y, Hu X, Shentu J

Drug Design, Development and Therapy 2020, 14:613-620

Published Date: 13 February 2020

Silibinin Augments the Antifibrotic Effect of Valsartan Through Inactivation of TGF-β1 Signaling in Kidney

Liu R, Wang Q, Ding Z, Zhang X, Li Y, Zang Y, Zhang G

Drug Design, Development and Therapy 2020, 14:603-611

Published Date: 13 February 2020

Lysosomal Acid Lipase Deficiency: Therapeutic Options

Pastores GM, Hughes DA

Drug Design, Development and Therapy 2020, 14:591-601

Published Date: 11 February 2020

Regulations of miR-183-5p and Snail-Mediated Shikonin-Reduced Epithelial-Mesenchymal Transition in Cervical Cancer Cells

Tang Q, Liu L, Zhang H, Xiao J, Hann SS

Drug Design, Development and Therapy 2020, 14:577-589

Published Date: 11 February 2020

Minoxidil and Its Use in Hair Disorders: A Review [Corrigendum]

Suchonwanit P, Thammarucha S, Leerunyakul K

Drug Design, Development and Therapy 2020, 14:575-576

Published Date: 10 February 2020

Optimization of a Benzothiazole Indolene Scaffold Targeting Bacterial Cell Wall Assembly

Chauhan J, Yu W, Cardinale S, Opperman TJ, MacKerell AD Jr, Fletcher S, de Leeuw EPH

Drug Design, Development and Therapy 2020, 14:567-574

Published Date: 10 February 2020

Focus on Notoginsenoside R1 in Metabolism and Prevention Against Human Diseases

Liu H, Yang J, Yang W, Hu S, Wu Y, Zhao B, Hu H, Du S

Drug Design, Development and Therapy 2020, 14:551-565

Published Date: 7 February 2020

Potential Use of Microbial Surfactant in Microemulsion Drug Delivery System: A Systematic Review

Ohadi M, Shahravan A, Dehghannoudeh N, Eslaminejad T, Banat IM, Dehghannoudeh G

Drug Design, Development and Therapy 2020, 14:541-550

Published Date: 5 February 2020

In silico Analysis, Molecular Docking, Molecular Dynamic, Cloning, Expression and Purification of Chimeric Protein in Colorectal Cancer Treatment [Erratum]

Dana H, Mahmoodi Chalbatani G, Gharagouzloo E, Miri SR, Memari F, Rasoolzadeh R, Zinatizadeh MR, Kheirandish Zarandi P, Marmari V

Drug Design, Development and Therapy 2020, 14:539-540

Published Date: 5 February 2020

Panax Notoginseng Ameliorates Podocyte EMT by Targeting the Wnt/β-Catenin Signaling Pathway in STZ-Induced Diabetic Rats

Xie L, Zhai R, Chen T, Gao C, Xue R, Wang N, Wang J, Xu Y, Gui D

Drug Design, Development and Therapy 2020, 14:527-538

Published Date: 5 February 2020

Design, Synthesis and Biological Evaluation of New HDAC1 and HDAC2 Inhibitors Endowed with Ligustrazine as a Novel Cap Moiety

Al-Sanea MM, Gotina L, Mohamed MFA, Grace Thomas Parambi D, Gomaa HAM, Mathew B, Youssif BGM, Alharbi KS, Elsayed ZM, Abdelgawad MA, Eldehna WM

Drug Design, Development and Therapy 2020, 14:497-508

Published Date: 4 February 2020

New Isatin–Indole Conjugates: Synthesis, Characterization, and a Plausible Mechanism of Their in vitro Antiproliferative Activity

Al-Wabli RI, Almomen AA, Almutairi MS, Keeton AB, Piazza GA, Attia MI

Drug Design, Development and Therapy 2020, 14:483-495

Published Date: 3 February 2020

Metformin Activates the AMPK-mTOR Pathway by Modulating lncRNA TUG1 to Induce Autophagy and Inhibit Atherosclerosis

You G, Long X, Song F, Huang J, Tian M, Xiao Y, Deng S, Wu Q

Drug Design, Development and Therapy 2020, 14:457-468

Published Date: 3 February 2020

Development of a Novel Controlled-Release Tablet of Pregabalin: Formulation Variation and Pharmacokinetics in Dogs and Humans

Kim KH, Lim SH, Shim CR, Park J, Song WH, Kwon MC, Lee JH, Park JS, Choi HG

Drug Design, Development and Therapy 2020, 14:445-456

Published Date: 30 January 2020

Calycosin Influences the Metabolism of Five Probe Drugs in Rats

Wu M, Lin Y, Wei Y, Du H, Ying X, Tan W, Tang B

Drug Design, Development and Therapy 2020, 14:429-434

Published Date: 29 January 2020

A New Validated HPLC-MS/MS Method for Quantification and Pharmacokinetic Evaluation of Dovitinib, a Multi-Kinase Inhibitor, in Mouse Plasma

AlRabiah H, Kadi AA, Aljohar HI, Attwa MW, Al-Shakliah NS, Attia SM, Mostafa GAE

Drug Design, Development and Therapy 2020, 14:407-415

Published Date: 28 January 2020

Reversible Small Molecule Inhibitors of MAO A and MAO B with Anilide Motifs

Hagenow J, Hagenow S, Grau K, Khanfar M, Hefke L, Proschak E, Stark H

Drug Design, Development and Therapy 2020, 14:371-393

Published Date: 28 January 2020

In silico Analysis, Molecular Docking, Molecular Dynamic, Cloning, Expression and Purification of Chimeric Protein in Colorectal Cancer Treatment

Dana H, Mahmoodi Chalbatani G, Gharagouzloo E, Miri SR, Memari F, Rasoolzadeh R, Zinatizadeh MR, Kheirandish Zarandi P, Marmari V

Drug Design, Development and Therapy 2020, 14:309-329

Published Date: 23 January 2020

Progress in Understanding the Molecular Mechanisms Underlying the Antitumour Effects of Ivermectin

Liu J, Zhang K, Cheng L, Zhu H, Xu T

Drug Design, Development and Therapy 2020, 14:285-296

Published Date: 21 January 2020

Apatinib in Patients with Relapsed or Refractory Diffuse Large B Cell Lymphoma: A Phase II, Open-Label, Single-Arm, Prospective Study

Ma X, Li L, Zhang L, Fu X, Li X, Wang X, Wu J, Sun Z, Zhang X, Feng X, Chang Y, Zhou Z, Nan F, Zhang J, Li Z, Zhang M

Drug Design, Development and Therapy 2020, 14:275-284

Published Date: 22 January 2020

The Impact of Loading Dose on Outcome in Stroke Patients Receiving Low-Dose Tissue Plasminogen Activator Thrombolytic Therapy

Wong YS, Sung SF, Wu CS, Hsu YC, Su YH, Hung LC, Ong CT

Drug Design, Development and Therapy 2020, 14:257-263

Published Date: 17 January 2020

Enhancing Betulinic Acid Dissolution Rate and Improving Antitumor Activity via Nanosuspension Constructed by Anti-Solvent Technique

Li S, Zhang J, Fang Y, Yi J, Lu Z, Chen Y, Guo B

Drug Design, Development and Therapy 2020, 14:243-256

Published Date: 16 January 2020

Electrospun PLA Fibers Containing Metronidazole for Periodontal Disease

Budai-Szűcs M, Léber A, Cui L, Józó M, Vályi P, Burián K, Kirschweng B, Csányi E, Pukánszky B

Drug Design, Development and Therapy 2020, 14:233-242

Published Date: 16 January 2020

Discovery of a Novel Benzenesulfonamide Analogue That Inhibits Proliferation and Metastasis Against Ovarian Cancer OVCAR-8 Cells

Jia Y, Li M, Cao Y, Feng W, Li X, Xue W, Shi H

Drug Design, Development and Therapy 2020, 14:207-216

Published Date: 15 January 2020

Baicalin Ameliorates Dexamethasone-Induced Osteoporosis by Regulation of the RANK/RANKL/OPG Signaling Pathway

Zhao Y, Wang HL, Li TT, Yang F, Tzeng CM

Drug Design, Development and Therapy 2020, 14:195-206

Published Date: 15 January 2020

Curcumin Combined with Thalidomide Reduces Expression of STAT3 and Bcl-xL, Leading to Apoptosis in Acute Myeloid Leukemia Cell Lines

Mohammadi Kian M, Salemi M, Bahadoran M, Haghi A, Dashti N, Mohammadi S, Rostami S, Chahardouli B, Babakhani D, Nikbakht M

Drug Design, Development and Therapy 2020, 14:185-194

Published Date: 15 January 2020

Isoborneol Attenuates Low-Density Lipoprotein Accumulation and Foam Cell Formation in Macrophages

Wang Y, Li Z, Liu B, Wu R, Gong H, Su Z, Zhang S

Drug Design, Development and Therapy 2020, 14:167-173

Published Date: 15 January 2020

Aloin Inhibits the Proliferation and Migration of Gastric Cancer Cells by Regulating NOX2–ROS-Mediated Pro-Survival Signal Pathways

Wang Z, Tang T, Wang S, Cai T, Tao H, Zhang Q, Qi S, Qi Z

Drug Design, Development and Therapy 2020, 14:145-155

Published Date: 14 January 2020

Metabolic Stability Assessment of Larotrectinib Using Liquid Chromatography Tandem Mass Spectrometry

Attwa MW, Kadi AA, Darwish HW

Drug Design, Development and Therapy 2020, 14:111-119

Published Date: 10 January 2020

Suitability of Amoxicillin–Clavulanic Acid for Administration via Prolonged Infusion

Fawaz S, Dixon B, Barton S, Mohamed A, Nabhani-Gebara S

Drug Design, Development and Therapy 2020, 14:103-109

Published Date: 10 January 2020

Curcumin Attenuates Oxaliplatin-Induced Liver Injury and Oxidative Stress by Activating the Nrf2 Pathway

Lu Y, Wu S, Xiang B, Li L, Lin Y

Drug Design, Development and Therapy 2020, 14:73-85

Published Date: 9 January 2020

Sappanone A Protects Against Myocardial Ischemia Reperfusion Injury by Modulation of Nrf2

Shi X, Tao G, Ji L, Tian G

Drug Design, Development and Therapy 2020, 14:61-71

Published Date: 8 January 2020

Engineering of Naproxen Loaded Polymer Hybrid Enteric Microspheres for Modified Release Tablets: Development, Characterization, in silico Modelling and in vivo Evaluation

Hameed HA, Khan S, Shahid M, Ullah R, Bari A, Ali SS, Hussain Z, Sohail M, Khan SU, Htar TT

Drug Design, Development and Therapy 2020, 14:27-41

Published Date: 7 January 2020

NMMHC IIA Inhibition Ameliorates Cerebral Ischemic/Reperfusion-Induced Neuronal Apoptosis Through Caspase-3/ROCK1/MLC Pathway

Wang GY, Wang TZ, Zhang YY, Li F, Yu BY, Kou JP

Drug Design, Development and Therapy 2020, 14:13-25

Published Date: 6 January 2020

Dexmedetomidine Promotes Hippocampal Neurogenesis and Improves Spatial Learning and Memory in Neonatal Rats

Zhang Y, Gao Q, Wu Z, Xue H, Liu B, Zhao P

Drug Design, Development and Therapy 2019, 13:4439-4449

Published Date: 3 January 2020

Developmental Pharmacogenetics of SLCO2B1 on Montelukast Pharmacokinetics in Chinese Children

Li Q, Wang K, Shi HY, Wu YE, Zhou Y, Kan M, Zheng Y, Hao GX, Yang XM, Yang YL, Su LQ, Wang XL, Jacqz-Aigrain E, Zhou J, Zhao W

Drug Design, Development and Therapy 2019, 13:4405-4411

Published Date: 27 December 2019

An Efficient, Lung-Targeted, Drug-Delivery System To Treat Asthma Via Microparticles

SreeHarsha N, Venugopala KN, Nair AB, Roopashree TS, Attimarad M, Hiremath JG, Al-Dhubiab BE, Ramnarayanan C, Shinu P, Handral M, Haroun M, Tratrat C

Drug Design, Development and Therapy 2019, 13:4389-4403

Published Date: 27 December 2019

Levonadifloxacin, a Novel Broad-Spectrum Anti-MRSA Benzoquinolizine Quinolone Agent: Review of Current Evidence

Bhagwat SS, Nandanwar M, Kansagara A, Patel A, Takalkar S, Chavan R, Periasamy H, Yeole R, Deshpande PK, Bhavsar S, Bhatia A, Ahdal J, Jain R, Patel M

Drug Design, Development and Therapy 2019, 13:4351-4365

Published Date: 24 December 2019

Memory Impairment Induced by Chronic Psychosocial Stress Is Prevented by L-Carnitine

Rababa'h SY, Alzoubi KH, Hammad HM, Alquraan L, El-Salem K

Drug Design, Development and Therapy 2019, 13:4341-4350

Published Date: 19 December 2019

Efficacy and Safety of Umbilical Cord Mesenchymal Stem Cell Therapy for Rheumatoid Arthritis Patients: A Prospective Phase I/II Study

Wang L, Huang S, Li S, Li M, Shi J, Bai W, Wang Q, Zheng L, Liu Y

Drug Design, Development and Therapy 2019, 13:4331-4340

Published Date: 19 December 2019

AR-42: A Pan-HDAC Inhibitor with Antitumor and Antiangiogenic Activities in Esophageal Squamous Cell Carcinoma

Zhu Y, Yuan T, Zhang Y, Shi J, Bai L, Duan X, Tong R, Zhong L

Drug Design, Development and Therapy 2019, 13:4321-4330

Published Date: 19 December 2019

A Novel Nanomicellar Combination of Fenretinide and Lenalidomide Shows Marked Antitumor Activity in a Neuroblastoma Xenograft Model

Orienti I, Nguyen F, Guan P, Kolla V, Calonghi N, Farruggia G, Chorny M, Brodeur GM

Drug Design, Development and Therapy 2019, 13:4305-4319

Published Date: 19 December 2019

The Protective Role of Tanshinone IIA in Silicosis Rat Model via TGF-β1/Smad Signaling Suppression, NOX4 Inhibition and Nrf2/ARE Signaling Activation

Feng F, Cheng P, Zhang H, Li N, Qi Y, Wang H, Wang Y, Wang W

Drug Design, Development and Therapy 2019, 13:4275-4290

Published Date: 18 December 2019

Valproic Acid Addresses Neuroendocrine Differentiation of LNCaP Cells and Maintains Cell Survival

Giordano F, Naimo GD, Nigro A, Romeo F, Paolì A, De Amicis F, Vivacqua A, Morelli C, Mauro L, Panno ML

Drug Design, Development and Therapy 2019, 13:4265-4274

Published Date: 18 December 2019

Small-Molecule Intervention At The Dimerization Interface Of Survivin By Novel Rigidized Scaffolds

Ibrahim TM, Ernst C, Lange A, Hennig S, Boeckler FM

Drug Design, Development and Therapy 2019, 13:4247-4263

Published Date: 18 December 2019

Synthesis of Novel Xanthone Analogues and Their Growth Inhibitory Activity Against Human Lung Cancer A549 Cells

Wu J, Dai J, Zhang Y, Wang J, Huang L, Ding H, Li T, Zhang Y, Mao J, Yu S

Drug Design, Development and Therapy 2019, 13:4239-4246

Published Date: 13 December 2019

Molecular Requirements for the Expression of Antiplatelet Effects by Synthetic Structural Optimized Analogues of the Anticancer Drugs Imatinib and Nilotinib

Pantazi D, Ntemou N, Brentas A, Alivertis D, Skobridis K, Tselepis AD

Drug Design, Development and Therapy 2019, 13:4225-4238

Published Date: 12 December 2019

The Effect of Glutamine Supplementation on Oxidative Stress and Matrix Metalloproteinase 2 and 9 After Exhaustive Exercise

Nemati A, Alipanah-Moghadam R, Molazadeh L, Naghizadeh Baghi A

Drug Design, Development and Therapy 2019, 13:4215-4223

Published Date: 11 December 2019

Drug–Drug Interactions Of Amiodarone And Quinidine On The Pharmacokinetics Of Eliglustat In Rats

Wang Q, Wang H, Zhong Y, Zhang Q

Drug Design, Development and Therapy 2019, 13:4207-4213

Published Date: 12 December 2019

In Silico, Cytotoxic and Antioxidant Potential of Novel Ester, 3-hydroxyoctyl -5- trans-docosenoate Isolated from Anchusa arvensis (L.) M.Bieb. Against HepG-2 Cancer Cells

Hussain S, Ullah F, Ayaz M, Ali Shah SA, Ali Shah AH, Shah SM, Wadood A, Aman W, Ullah R, Shahat AA, Nasr FA

Drug Design, Development and Therapy 2019, 13:4195-4205

Published Date: 10 December 2019

Pharmacological Evaluation of Aldehydic-Pyrrolidinedione Against HCT-116, MDA-MB231, NIH/3T3, MCF-7 Cancer Cell Lines, Antioxidant and Enzyme Inhibition Studies

Ahmad A, Ullah F, Sadiq A, Ayaz M, Rahim H, Rashid U, Ahmad S, Jan MS, Ullah R, Shahat AA, Mahmood HM

Drug Design, Development and Therapy 2019, 13:4185-4194

Published Date: 10 December 2019

Preparation of a Novel One-Armed Anti-c-Met Antibody with Antitumor Activity Against Hepatocellular Carcinoma

Yin Y, Guo J, Teng F, Yu L, Jiang Y, Xie K, Jiang M, Fang J

Drug Design, Development and Therapy 2019, 13:4173-4184

Published Date: 10 December 2019

Inhibition Of JNK Phosphorylation By Curcumin Analog C66 Protects LPS-Induced Acute Lung Injury

Xiao Z, Xu F, Zhu X, Bai B, Guo L, Liang G, Shan X, Zhang Y, Zhao Y, Zhang B

Drug Design, Development and Therapy 2019, 13:4161-4171

Published Date: 10 December 2019

A Novel Hybrid Compound LLP2A-Alendronate Accelerates Open Fracture Healing in a Rabbit Model [Corrigendum]

Wang Z, Zhao Y, Zhang D, Qi B, Xiao W, Hu X, Yu A

Drug Design, Development and Therapy 2019, 13:4159-4160

Published Date: 9 December 2019

Catalpol Enhances Neurogenesis And Inhibits Apoptosis Of New Neurons Via BDNF, But Not The BDNF/Trkb Pathway

Zhu HF, Shao Y, Qin L, Wang JH, Feng S, Jiang YB, Wan D

Drug Design, Development and Therapy 2019, 13:4145-4157

Published Date: 10 December 2019

Radioprotective Potential of Sulindac Sulfide to Prevent DNA Damage Due to Ionizing Radiation

Torabizadeh SA, Rezaeifar M, Jomehzadeh A, Nabizadeh Haghighi F, Ansari M

Drug Design, Development and Therapy 2019, 13:4127-4134

Published Date: 6 December 2019

Efficacy and Safety of Combined Vitrectomy with Intravitreal Dexamethasone Implant for Advanced Stage Epiretinal Membrane

Iovino C, Giannaccare G, Pellegrini M, Bernabei F, Braghiroli M, Caporossi T, Peiretti E

Drug Design, Development and Therapy 2019, 13:4107-4114

Published Date: 3 December 2019

Profile of Tofacitinib in the Treatment of Ulcerative Colitis: An Evidence-Based Review of Recent Data

Varyani F, Argyriou K, Phillips F, Tsakiridou E, Moran GW

Drug Design, Development and Therapy 2019, 13:4091-4105

Published Date: 2 December 2019

Liraglutide Improves Non-Alcoholic Fatty Liver Disease In Diabetic Mice By Modulating Inflammatory Signaling Pathways

Luo Y, Yang P, Li Z, Luo Y, Shen J, Li R, Zheng H, Liang Y, Xia N

Drug Design, Development and Therapy 2019, 13:4065-4074

Published Date: 2 December 2019

Delivery Of Curcumin Nanoliposomes Using Surface Modified With CD133 Aptamers For Prostate Cancer

Ma Q, Qian W, Tao W, Zhou Y, Xue B

Drug Design, Development and Therapy 2019, 13:4021-4033

Published Date: 28 November 2019

Transformation of Meloxicam Containing Nanosuspension into Surfactant-Free Solid Compositions to Increase the Product Stability and Drug Bioavailability for Rapid Analgesia

Bartos C, Ambrus R, Katona G, Sovány T, Gáspár R, Márki Á, Ducza E, Ivanov A, Tömösi F, Janáky T, Szabó-Révész P

Drug Design, Development and Therapy 2019, 13:4007-4020

Published Date: 28 November 2019

A Network Pharmacology-Based Strategy For Predicting Active Ingredients And Potential Targets Of LiuWei DiHuang Pill In Treating Type 2 Diabetes Mellitus

He D, Huang JH, Zhang ZY, Du Q, Peng WJ, Yu R, Zhang SF, Zhang SH, Qin YH

Drug Design, Development and Therapy 2019, 13:3989-4005

Published Date: 28 November 2019

Postconditioning Protection Against Myocardiocyte Anoxia/Reoxygenation Injury From Penehyclidine Hydrochloride

Ren JY, Lin DM, Wang CB, Yang YL, Wang ZQ, Cui BQ, Ma J

Drug Design, Development and Therapy 2019, 13:3977-3988

Published Date: 26 November 2019

Effects Of Triptolide On Tooth Movement And Root Resorption In Rats

Yang F, Wang XX, Ma D, Cui Q, Zheng DH, Liu XC, Zhang J

Drug Design, Development and Therapy 2019, 13:3963-3975

Published Date: 25 November 2019

Icariin Alleviates IL-1β-Induced Matrix Degradation By Activating The Nrf2/ARE Pathway In Human Chondrocytes

Zuo S, Zou W, Wu RM, Yang J, Fan JN, Zhao XK, Li HY

Drug Design, Development and Therapy 2019, 13:3949-3961

Published Date: 21 November 2019

Alteration of Amino Acid Profiling Influenced by the Active Ingredients of DanHong Injection After Prescription Optimization

Guo Z, Zhu Y, Xu W, Luo K, Xiao H, Wang Z

Drug Design, Development and Therapy 2019, 13:3939-3947

Published Date: 21 November 2019

Assessment Of Spanlastic Vesicles Of Zolmitriptan For Treating Migraine In Rats

El-Nabarawy NA, Teaima MH, Helal DA

Drug Design, Development and Therapy 2019, 13:3929-3937

Published Date: 21 November 2019

The Effects Of Sevoflurane On The Progression And Cisplatinum Sensitivity Of Cervical Cancer Cells

Xue F, Xu Y, Song Y, Zhang W, Li R, Zhu X

Drug Design, Development and Therapy 2019, 13:3919-3928

Published Date: 18 November 2019

Efficacy And Safety Of Apatinib Treatment In Platinum-Resistant Recurrent Epithelial Ovarian Cancer: A Real World Study

Zhang J, Li A, Jiang Q, Zheng F, Zhu H

Drug Design, Development and Therapy 2019, 13:3913-3918

Published Date: 15 November 2019

Hesperidin: A Therapeutic Agent For Obesity

Xiong H, Wang J, Ran Q, Lou G, Peng C, Gan Q, Hu J, Sun J, Yao R, Huang Q

Drug Design, Development and Therapy 2019, 13:3855-3866

Published Date: 12 November 2019

Safety, pharmacokinetics and pharmacodynamics of the selective glucocorticoid receptor modulator AZD7594, following inhalation in healthy Japanese volunteers

Prothon S, Wählby Hamrén U, Tehler U, Yoon E, Forsman H, Arfvidsson C, Aggarwal A, Chen Y

Drug Design, Development and Therapy 2019, 13:3845-3853

Published Date: 12 November 2019

Comparing The Efficacy Of An Anti-Human VEGF-A Neutralizing Antibody Versus Bevacizumab On A Laser-Induced Choroidal Neovascularization (CNV) Rhesus Monkey Model

Olvera-Montaño O, Baiza-Duran L, Quintana-Hau JD, Quiñonez-Alvarado MG, Zeng W, Gong L, Muñoz-Villegas P

Drug Design, Development and Therapy 2019, 13:3813-3821

Published Date: 4 November 2019

Smart Targeting To Improve Cancer Therapeutics

Morales-Cruz M, Delgado Y, Castillo B, Figueroa CM, Molina AM, Torres A, Milián M, Griebenow K

Drug Design, Development and Therapy 2019, 13:3753-3772

Published Date: 30 October 2019

Baseline Lymphopenia: A Predictor Of Poor Outcomes In HER2 positive Metastatic Breast Cancer Treated With Trastuzumab

Che YQ, Zhang Y, Wang D, Liu HY, Shen D, Luo Y

Drug Design, Development and Therapy 2019, 13:3727-3734

Published Date: 29 October 2019

miR- 26a Sensitizes Melanoma Cells To Dabrafenib Via Targeting HMGB1-Dependent Autophagy Pathways

Yu Y, Xiang N, Lin M, Huang JW, Zhang J, Cheng B, Ji C

Drug Design, Development and Therapy 2019, 13:3717-3726

Published Date: 29 October 2019

Cardio- Renal Outcomes With Long- Term Agalsidase Alfa Enzyme Replacement Therapy: A 10- Year Fabry Outcome Survey (FOS) Analysis

Ramaswami U, Beck M, Hughes D, Kampmann C, Botha J, Pintos-Morell G, West ML, Niu DM, Nicholls K, Giugliani R

Drug Design, Development and Therapy 2019, 13:3705-3715

Published Date: 25 October 2019

Exosomes Derived From Bone Marrow Mesenchymal Stem Cells Inhibit Complement Activation In Rats With Spinal Cord Injury

Zhao C, Zhou X, Qiu J, Xin D, Li T, Chu X, Yuan H, Wang H, Wang Z, Wang D

Drug Design, Development and Therapy 2019, 13:3693-3704

Published Date: 24 October 2019

Glucoside Derivatives Of Podophyllotoxin: Synthesis, Physicochemical Properties, And Cytotoxicity

Zi CT, Yang L, Kong QH, Li HM, Yang XZ, Ding ZT, Jiang ZH, Hu JM, Zhou J

Drug Design, Development and Therapy 2019, 13:3683-3692

Published Date: 23 October 2019

Olmesartan Medoxomil, An Angiotensin II-Receptor Blocker, Ameliorates Renal Injury In db/db Mice

Zhu Y, Li ZL, Ding A, Yang H, Zhu WP, Cui TX, Zhang HT, Zhang H

Drug Design, Development and Therapy 2019, 13:3657-3667

Published Date: 22 October 2019

The Effect Of Food On The Pharmacokinetic Properties And Bioequivalence Of Two Formulations Of Levocetirizine Dihydrochloride In Healthy Chinese Volunteers

Cheng Y, Lin BJ, Guo JH, Huang BL, Fang LP, Que WC, Liu MB, Chen XF, Qiu HQ

Drug Design, Development and Therapy 2019, 13:3625-3634

Published Date: 18 October 2019

In-vitro blood-brain barrier models for drug screening and permeation studies: an overview

Bagchi S, Chhibber T, Lahooti B, Verma A, Borse V, Jayant RD

Drug Design, Development and Therapy 2019, 13:3591-3605

Published Date: 18 October 2019

Diammonium Glycyrrhizinate Mitigates Liver Injury Via Inhibiting Proliferation Of NKT Cells And Promoting Proliferation Of Tregs

Gao M, Li X, He L, Yang J, Ye X, Xiao F, Wei H

Drug Design, Development and Therapy 2019, 13:3579-3589

Published Date: 16 October 2019

Indole-2-Carboxamide Derivative LG25 Inhibits Triple-Negative Breast Cancer Growth By Suppressing Akt/mTOR/NF-κB Signalling Pathway

Xu X, Rajamanickam V, Shu S, Liu Z, Yan T, He J, Liu Z, Guo G, Liang G, Wang Y

Drug Design, Development and Therapy 2019, 13:3539-3550

Published Date: 11 October 2019

Aucubin Protects Chondrocytes Against IL-1β-Induced Apoptosis In Vitro And Inhibits Osteoarthritis In Mice Model

Wang B, Jiang Y, Yao Z, Chen P, Yu B, Wang S

Drug Design, Development and Therapy 2019, 13:3529-3538

Published Date: 9 October 2019

20(S)-Ginsenoside Rg3 Promotes Senescence And Apoptosis In Gallbladder Cancer Cells Via The P53 Pathway [Corrigendum]

Zhang F, Li M, Wu X, Hu Y, Cao Y, Wang X, Xiang S, Li H, Jiang L, Tan Z, Lu W, Weng H, Shu Y, Gong W, Wang X, Zhang Y, Shi W, Dong P, Gu J, Liu Y

Drug Design, Development and Therapy 2019, 13:3527-3528

Published Date: 8 October 2019

Thrombospondin-1 Serum Levels In Hypertensive Patients With Endothelial Dysfunction After One Year Of Treatment With Perindopril

Buda V, Andor M, Cristescu C, Tomescu MC, Muntean DM, Bâibâță DE, Bordejevic DA, Danciu C, Dalleur O, Coricovac D, Crainiceanu Z, Tudor A, Ledeti I, Petrescu L

Drug Design, Development and Therapy 2019, 13:3515-3526

Published Date: 8 October 2019

The Osteoprotective Effects Of Kaempferol: The Evidence From In Vivo And In Vitro Studies

Wong SK, Chin KY, Ima-Nirwana S

Drug Design, Development and Therapy 2019, 13:3497-3514

Published Date: 7 October 2019

Enzyme Inhibitory, Antioxidant And Antibacterial Potentials Of Synthetic Symmetrical And Unsymmetrical Thioureas

Naz S, Zahoor M, Umar MN, Ali B, Ullah R, Shahat AA, Mahmood HM, Sahibzada MUK

Drug Design, Development and Therapy 2019, 13:3485-3495

Published Date: 7 October 2019

Dexmedetomidine Attenuates Neuroinflammation In LPS-Stimulated BV2 Microglia Cells Through Upregulation Of miR-340

Bao Y, Zhu Y, He G, Ni H, Liu C, Ma L, Zhang L, Shi D

Drug Design, Development and Therapy 2019, 13:3465-3475

Published Date: 3 October 2019

Efficacy, Safety And Feasibility Of Antiemetic Prophylaxis With Fosaprepitant, Granisetron And Dexamethasone In Pediatric Patients With Hemato-Oncological Malignancies

Cabanillas Stanchi KM, Ebinger M, Hartmann U, Queudeville M, Feucht J, Ost M, Koch MS, Malaval C, Mezger M, Schober S, Weber S, Michaelis S, Lange V, Lang P, Handgretinger R, Döring M

Drug Design, Development and Therapy 2019, 13:3439-3451

Published Date: 30 September 2019

The Efficacy And Safety Of Apatinib Treatment For Patients With Metastatic Or Recurrent Cervical Cancer: A Retrospective Study

Yu J, Xu Z, Li A, Zhang J, Wang Y, Zhao H, Zhu H

Drug Design, Development and Therapy 2019, 13:3419-3424

Published Date: 26 September 2019

Hydrogels For Peptide Hormones Delivery: Therapeutic And Tissue Engineering Applications

Doostmohammadi M, Ameri A, Mohammadinejad R, Dehghannoudeh N, Banat IM, Ohadi M, Dehghannoudeh G

Drug Design, Development and Therapy 2019, 13:3405-3418

Published Date: 26 September 2019

Paclitaxel alleviated sepsis-induced acute lung injury by activating MUC1 and suppressing TLR-4/NF-κB pathway

Wang YM, Ji R, Chen WW, Huang SW, Zheng YJ, Yang ZT, Qu HP, Chen H, Mao EQ, Chen Y, Chen EZ

Drug Design, Development and Therapy 2019, 13:3391-3404

Published Date: 24 September 2019

Design, Synthesis, And Evaluation Of Cyanopyridines As Anti-Colorectal Cancer Agents Via Inhibiting STAT3 Pathway

Xu L, Shi L, Qiu S, Chen S, Lin M, Xiang Y, Zhao C, Zhu J, Shen L, Zuo Z

Drug Design, Development and Therapy 2019, 13:3369-3381

Published Date: 24 September 2019

Effects of loratadine, a histamine H1 receptor antagonist, on the skeletal system of young male rats

Folwarczna J, Konarek N, Freier K, Karbowniczek D, Londzin P, Janas A

Drug Design, Development and Therapy 2019, 13:3357-3367

Published Date: 23 September 2019

Effect Of Chinese Herb Danzhi Xiaoyao Pills On Pharmacokinetics Of Venlafaxine In Beagles

Zhu Y, Li S, Chen K, Ma K, Wu D, Qiu X

Drug Design, Development and Therapy 2019, 13:3343-3355

Published Date: 20 September 2019

Bioequivalence Study Of A Fixed-Dose Combination Tablet Containing Melitracen 10 mg And Flupentixol 0.5 mg In Healthy Chinese Volunteers Under Fasted And Fed Conditions

Wu L, Xu C, Wu G, Zhou H, Lv D, Zhai Y, Huang Y, Tang W, Li F, Shentu J

Drug Design, Development and Therapy 2019, 13:3331-3342

Published Date: 19 September 2019

Effects of quercetin, sitagliptin alone or in combination in testicular toxicity induced by doxorubicin in rats

Ahmed ZA, Abtar AN, Othman HH, Aziz TA

Drug Design, Development and Therapy 2019, 13:3321-3329

Published Date: 20 September 2019

Muscone Promotes The Adipogenic Differentiation Of Human Gingival Mesenchymal Stem Cells By Inhibiting The Wnt/β-Catenin Signaling Pathway

Yuan WX, Wang XX, Zheng DH, Ma D, Cui Q, Yang F, Zhang J

Drug Design, Development and Therapy 2019, 13:3291-3306

Published Date: 18 September 2019

A novel curcumin-loaded composite dressing facilitates wound healing due to its natural antioxidant effect

Zhao Y, Dai C, Wang Z, Chen W, Liu J, Zhuo R, Yu A, Huang S

Drug Design, Development and Therapy 2019, 13:3269-3280

Published Date: 16 September 2019

Carbocisteine inhibits the expression of Muc5b in COPD mouse model

Song Y, Wang W, Xie Y, Xiang B, Huang X, Guan W, Zheng J

Drug Design, Development and Therapy 2019, 13:3259-3268

Published Date: 16 September 2019

Identification of substandard drug products using electronic tongue: cefdinir suspension as a pilot example

Abu-Khalaf N, Zaid AN, Jaradat N, Alkilany AM, Abulateefeh SR, Al Ramahi R, Ghanem M

Drug Design, Development and Therapy 2019, 13:3249-3258

Published Date: 16 September 2019

Preclinical pharmacodynamic and pharmacokinetic characterization of the major metabolites of cariprazine

Kiss B, Némethy Z, Fazekas K, Kurkó D, Gyertyán I, Sághy K, Laszlovszky I, Farkas B, Kirschner N, Bolf-Terjéki E, Balázs O, Lendvai B

Drug Design, Development and Therapy 2019, 13:3229-3248

Published Date: 16 September 2019

Ubenimex induces apoptotic and autophagic cell death in rat GH3 and MMQ cells through the ROS/ERK pathway

Wang Y, Pang B, Zhang R, Fu Y, Pang Q

Drug Design, Development and Therapy 2019, 13:3217-3228

Published Date: 12 September 2019

Palliative chemotherapy with or without anti-EGFR therapy for de novo metastatic nasopharyngeal carcinoma: a propensity score-matching study

Sun XS, Liang YJ, Li XY, Liu SL, Chen QY, Tang LQ, Mai HQ

Drug Design, Development and Therapy 2019, 13:3207-3216

Published Date: 10 September 2019

Downregulation of p66Shc can reduce oxidative stress and apoptosis in oxidative stress model of marginal cells of stria vascularis in Sprague Dawley rats

Hao C, Wu X, Zhou R, Zhang H, Zhou Y, Wang X, Feng Y, Mei L, He C, Cai X, Wu L

Drug Design, Development and Therapy 2019, 13:3199-3206

Published Date: 10 September 2019

Omalizumab for chronic spontaneous urticaria in “complex” patients: data from real-life clinical practice

Vollono L, Piccolo A, Lanna C, Esposito M, Bavetta M, Campione E, Bianchi L, Diluvio L

Drug Design, Development and Therapy 2019, 13:3181-3186

Published Date: 6 September 2019

Emodin-induced autophagy against cell apoptosis through the PI3K/AKT/mTOR pathway in human hepatocytes

Zheng X, Yang S, Zhang R, Wang S, Li G, Zhou S

Drug Design, Development and Therapy 2019, 13:3171-3180

Published Date: 3 September 2019

Mifepristone inhibits IGF-1 signaling pathway in the treatment of uterine leiomyomas

Shen Q, Zou S, Sheng B, Zhao M, Sun LZ, Zhu X

Drug Design, Development and Therapy 2019, 13:3161-3170

Published Date: 3 September 2019

Dexmedetomidine protects H9c2 cardiomyocytes against oxygen-glucose deprivation/reoxygenation-induced intracellular calcium overload and apoptosis through regulating FKBP12.6/RyR2 signaling

Yuan M, Meng XW, Ma J, Liu H, Song SY, Chen QC, Liu HY, Zhang J, Song N, Ji FH, Peng K

Drug Design, Development and Therapy 2019, 13:3137-3149

Published Date: 2 September 2019

Pharmacokinetic and bioequivalence study between two formulations of S-1 in Korean gastric cancer patients

Lee HW, Seong SJ, Kang WY, Ohk B, Gwon MR, Kim BK, Cho S, Cho K, Sung YK, Yoon YR, Kim JG

Drug Design, Development and Therapy 2019, 13:3127-3136

Published Date: 3 September 2019

Silibinin attenuates high-fat diet-induced renal fibrosis of diabetic nephropathy

Liu K, Zhou S, Liu J, Wang Y, Zhu F, Liu M

Drug Design, Development and Therapy 2019, 13:3117-3126

Published Date: 29 August 2019

Therapeutic potential of BLT1 antagonist for COPD: involvement of inducing autophagy and ameliorating inflammation

Zhang L, Huang J, Dong R, Feng Y, Zhou M

Drug Design, Development and Therapy 2019, 13:3105-3116

Published Date: 4 September 2019

Polyphyllin VI induces apoptosis and autophagy in human osteosarcoma cells by modulation of ROS/JNK activation

Yuan YL, Jiang N, Li ZY, Song ZZ, Yang ZH, Xue WH, Zhang XJ, Du Y

Drug Design, Development and Therapy 2019, 13:3091-3103

Published Date: 28 August 2019

Antiproliferative activity and possible mechanism of action of certain 5-methoxyindole tethered C-5 functionalized isatins

Almutairi MS, Hassan ES, Keeton AB, Piazza GA, Abdelhameed AS, Attia MI

Drug Design, Development and Therapy 2019, 13:3069-3078

Published Date: 27 August 2019

Ketamine and depression: a narrative review

Corriger A, Pickering G

Drug Design, Development and Therapy 2019, 13:3051-3067

Published Date: 27 August 2019

Arsenic sulfide induces miR-4665-3p to inhibit gastric cancer cell invasion and migration

Zhang X, Tan Z, Kang T, Zhu C, Chen S

Drug Design, Development and Therapy 2019, 13:3037-3049

Published Date: 26 August 2019

Isolation, pharmacological evaluation and molecular docking studies of bioactive compounds from Grewia optiva

Ul Bari W, Zahoor M, Zeb A, Sahibzada MUK, Ullah R, Shahat AA, Mahmood HM, Khan I

Drug Design, Development and Therapy 2019, 13:3029-3036

Published Date: 26 August 2019

Synthesis and antitumor evaluation of neolaxiflorin B inspired compounds

Liu JP, Xiao YZ, Hu Y, Li XN, Wu MJ, Zhao Y, Zhao Y, Ma ZJ, Shen J

Drug Design, Development and Therapy 2019, 13:3021-3028

Published Date: 23 August 2019

Network pharmacology study on the active components of Pterocypsela elata and the mechanism of their effect against cerebral ischemia

Niu B, Zhang H, Li C, Yan F, Song Y, Hai G, Jiao Y, Feng Y

Drug Design, Development and Therapy 2019, 13:3009-3019

Published Date: 5 September 2019

The development of an oral GLP-1 receptor agonist for the management of type 2 diabetes: evidence to date

Antza C, Nirantharakumar K, Doundoulakis I, Tahrani AA, Toulis KA

Drug Design, Development and Therapy 2019, 13:2985-2996

Published Date: 22 August 2019

Attractor – a new turning point in drug discovery

Hou X, Li M, Jia C, Zhang X, Wang Y

Drug Design, Development and Therapy 2019, 13:2957-2968

Published Date: 22 August 2019

Total extract of Xin Jia Xuan Bai Cheng Qi decoction inhibits pulmonary fibrosis via the TGF-β/Smad signaling pathways in vivo and in vitro

Qin H, Wen HT, Gu KJ, Hu XD, Yang T, Yan XF, Ye TJ, Huo JL, Hu J

Drug Design, Development and Therapy 2019, 13:2873-2886

Published Date: 19 August 2019

Validated UPLC-MS/MS method for quantification of fruquintinib in rat plasma and its application to pharmacokinetic study

Mei YB, Luo SB, Ye LY, Zhang Q, Guo J, Qiu XJ, Xie SL

Drug Design, Development and Therapy 2019, 13:2865-2871

Published Date: 15 August 2019

Overexpression of SOX9 alleviates the progression of human osteoarthritis in vitro and in vivo

Ouyang Y, Wang W, Tu B, Zhu Y, Fan C, Li Y

Drug Design, Development and Therapy 2019, 13:2833-2842

Published Date: 13 August 2019

Protective effects of tiopronin against oxidative stress in severely burned patients

Qin FJ, Hu XH, Chen Z, Chen X, Shen YM

Drug Design, Development and Therapy 2019, 13:2827-2832

Published Date: 13 August 2019

eIF2α promotes vascular remodeling via autophagy in monocrotaline-induced pulmonary arterial hypertension rats

Guo L, Li Y, Tian Y, Gong S, Chen X, Peng T, Wang A, Jiang Z

Drug Design, Development and Therapy 2019, 13:2799-2809

Published Date: 13 August 2019

Minoxidil and its use in hair disorders: a review

Suchonwanit P, Thammarucha S, Leerunyakul K

Drug Design, Development and Therapy 2019, 13:2777-2786

Published Date: 9 August 2019

Effects of acarbose and metformin on the inflammatory state in newly diagnosed type 2 diabetes patients: a one-year randomized clinical study

Mo D, Liu S, Ma H, Tian H, Yu H, Zhang X, Tong N, Liao J, Ren Y

Drug Design, Development and Therapy 2019, 13:2769-2776

Published Date: 9 August 2019

Cerebral protection of epigallocatechin gallate (EGCG) via preservation of mitochondrial function and ERK inhibition in a rat resuscitation model

Qin S, Chen MH, Fang W, Tan XF, Xie L, Yang YG, Qin T, Li N

Drug Design, Development and Therapy 2019, 13:2759-2768

Published Date: 7 August 2019

Liraglutide attenuates cardiac remodeling and improves heart function after abdominal aortic constriction through blocking angiotensin II type 1 receptor in rats

Zheng RH, Bai XJ, Zhang WW, Wang J, Bai F, Yan CP, James EA, Bose HS, Wang NP, Zhao Z

Drug Design, Development and Therapy 2019, 13:2745-2757

Published Date: 6 August 2019

Neuroprotective effects of melatonin and celecoxib against ethanol-induced neurodegeneration: a computational and pharmacological approach

Al Kury LT, Zeb A, Abidin ZU, Irshad N, Malik I, Alvi AM, Khalil AAK, Ahmad S, Faheem M, Khan AU, Shah FA, Li S

Drug Design, Development and Therapy 2019, 13:2715-2727

Published Date: 2 August 2019

Orcinol glucoside facilitates the shift of MSC fate to osteoblast and prevents adipogenesis via Wnt/β-catenin signaling pathway

Zhou X, Liu Z, Huang B, Yan H, Yang C, Li Q, Jin D

Drug Design, Development and Therapy 2019, 13:2703-2713

Published Date: 5 August 2019

Systemic taurine treatment provides neuroprotection against retinal photoreceptor degeneration and visual function impairments

Tao Y, He M, Yang Q, Ma Z, Qu Y, Chen W, Peng G, Teng D

Drug Design, Development and Therapy 2019, 13:2689-2702

Published Date: 7 August 2019

Dextromethorphan and memantine after ketamine analgesia: a randomized control trial

Martin E, Sorel M, Morel V, Marcaillou F, Picard P, Delage N, Tiberghien F, Crosmary MC, Najjar M, Colamarino R, Créach C, Lietar B, Brumauld de Montgazon G, Margot-Duclot A, Loriot MA, Narjoz C, Lambert C, Pereira B, Pickering G

Drug Design, Development and Therapy 2019, 13:2677-2688

Published Date: 2 August 2019

Carvedilol attenuates carbon tetrachloride-induced liver fibrosis and hepatic sinusoidal capillarization in mice

Wu Y, Li Z, Xiu AY, Meng DX, Wang SN, Zhang CQ

Drug Design, Development and Therapy 2019, 13:2667-2676

Published Date: 1 August 2019

An investigation of the stability of meropenem in elastomeric infusion devices

Foy F, Luna G, Martinez J, Nizich Z, Seet J, Lie K, Sunderland B, Czarniak P

Drug Design, Development and Therapy 2019, 13:2655-2665

Published Date: 1 August 2019

Efficacy of chloral hydrate oral solution for sedation in pediatrics: a systematic review and meta-analysis

Chen Z, Lin M, Huang Z, Zeng L, Huang L, Yu D, Zhang L

Drug Design, Development and Therapy 2019, 13:2643-2653

Published Date: 31 July 2019

Effects of ondansetron and [6]-gingerol on pica and gut microbiota in rats treated with cisplatin

Feng X, Cheng Q, Meng Q, Yang Y, Nie K

Drug Design, Development and Therapy 2019, 13:2633-2641

Published Date: 1 August 2019

Role of heat shock protein 22 in the protective effect of geranylgeranylacetone in response to oxidized-LDL

Gong R, Li XY, Chen HJ, Xu CC, Fang HY, Xiang J, Wu YQ

Drug Design, Development and Therapy 2019, 13:2619-2632

Published Date: 30 July 2019

Effects of losartan and atorvastatin on the development of early posttraumatic joint stiffness in a rat model

Baranowski A, Schlemmer L, Förster K, Slotina E, Mickan T, Truffel S, Klein A, Mattyasovszky SG, Hofmann A, Ritz U, Rommens PM

Drug Design, Development and Therapy 2019, 13:2603-2618

Published Date: 30 July 2019

Astragaloside IV protects endothelial progenitor cells from the damage of ox-LDL via the LOX-1/NLRP3 inflammasome pathway

Qian W, Cai X, Qian Q, Zhuang Q, Yang W, Zhang X, Zhao L

Drug Design, Development and Therapy 2019, 13:2579-2589

Published Date: 29 July 2019

Erythropoietin enhances osteogenic differentiation of human periodontal ligament stem cells via Wnt/β-catenin signaling pathway

Zheng DH, Wang XX, Ma D, Zhang LN, Qiao QF, Zhang J

Drug Design, Development and Therapy 2019, 13:2543-2552

Published Date: 26 July 2019

Downregulation of microRNA-23b-3p alleviates IL-1β-induced injury in chondrogenic CHON-001 cells

Yang Q, Zhou Y, Cai P, Fu W, Wang J, Wei Q, Li X

Drug Design, Development and Therapy 2019, 13:2503-2512

Published Date: 23 July 2019

Physicochemical properties and drug-release mechanisms of dual-release bilayer tablet containing mirabegron and fesoterodine fumarate

Lee HG, Park YS, Jeong JH, Kwon YB, Shin DH, Kim JY, Rhee YS, Park ES, Kim DW, Park CW

Drug Design, Development and Therapy 2019, 13:2459-2474

Published Date: 23 July 2019

Synthesis and antihepatotoxic activity of dihydropyrimidinone derivatives linked with 1,4-benzodioxane

Bhat MA, Al-Omar MA, Khan AA, Alanazi AM, Naglah AM

Drug Design, Development and Therapy 2019, 13:2393-2404

Published Date: 18 July 2019

A new approach of ocular nebulization with vitamin B12 versus oxytocin for the treatment of dry eye disease: an in vivo confocal microscopy study

Yang J, Liu Y, Xu Y, Li X, Fu J, Jiang X, Chou Y, Ma J, Hao R, Zhang R, Qiu W, Li X

Drug Design, Development and Therapy 2019, 13:2381-2391

Published Date: 18 July 2019

MicroRNA-664 suppresses the growth of cervical cancer cells via targeting c-Kit

Lv M, Ou R, Zhang Q, Lin F, Li X, Wang K, Xu Y

Drug Design, Development and Therapy 2019, 13:2371-2379

Published Date: 17 July 2019

Plumbagin promotes human hepatoma SMMC-7721 cell apoptosis via caspase-3/vimentin signal-mediated EMT

Wei Y, Lv B, Xie J, Zhang Y, Lin Y, Wang S, Zhong J, Chen Y, Peng Y, Ma J

Drug Design, Development and Therapy 2019, 13:2343-2355

Published Date: 15 July 2019

Lycopene protects against myocardial ischemia-reperfusion injury by inhibiting mitochondrial permeability transition pore opening

Li X, Jia P, Huang Z, Liu S, Miao J, Guo Y, Wu N, Jia D

Drug Design, Development and Therapy 2019, 13:2331-2342

Published Date: 11 July 2019

Differences in tolerability of pirfenidone between elderly and younger patients with idiopathic pulmonary fibrosis

Sakayori M, Terada J, Abe M, Hirasawa Y, Suzuki K, Yoshioka K, Tsushima K, Tatsumi K

Drug Design, Development and Therapy 2019, 13:2295-2303

Published Date: 11 July 2019

Durability of INI-containing regimens after switching from PI-containing regimens: a single-centre cohort of drug-experienced HIV-infected subjects

Giacomelli A, Ranzani A, Oreni L, Gervasi E, Lupo A, Ridolfo AL, Galli M, Rusconi S

Drug Design, Development and Therapy 2019, 13:2271-2282

Published Date: 9 July 2019

The protective effect and mechanism of the FXR agonist obeticholic acid via targeting gut microbiota in non-alcoholic fatty liver disease

Zhang DY, Zhu L, Liu HN, Tseng YJ, Weng SQ, Liu TT, Dong L, Shen XZ

Drug Design, Development and Therapy 2019, 13:2249-2270

Published Date: 5 July 2019

Jatrorrhizine inhibits colorectal carcinoma proliferation and metastasis through Wnt/β-catenin signaling pathway and epithelial–mesenchymal transition

Wang P, Gao XY, Yang SQ, Sun ZX, Dian LL, Qasim M, Phyo AT, Liang ZS, Sun YF

Drug Design, Development and Therapy 2019, 13:2235-2247

Published Date: 8 July 2019

Delivery of folic acid-modified liposomal curcumin for targeted cervical carcinoma therapy

Wang WY, Cao YX, Zhou X, Wei B

Drug Design, Development and Therapy 2019, 13:2205-2213

Published Date: 4 July 2019

Activation of the P38/CREB/MMP13 axis is associated with osteoarthritis

Ji B, Ma Y, Wang H, Fang X, Shi P

Drug Design, Development and Therapy 2019, 13:2195-2204

Published Date: 3 July 2019

Tablet or capsule form of generic mycophenolate mofetil (My-Rept®) after liver transplantation: a prospective randomized trial

Kim JM, Oh JW, Kim S, Rhu J, Lee JS, Kim KS, Choi GS, Joh JW

Drug Design, Development and Therapy 2019, 13:2187-2193

Published Date: 2 July 2019

Evaluation of novel pyrimidine derivatives as a new class of mushroom tyrosinase inhibitor

Mirmortazavi SS, Farvandi M, Ghafouri H, Mohammadi A, Shourian M

Drug Design, Development and Therapy 2019, 13:2169-2178

Published Date: 8 July 2019

Preemptive analgesia after lumbar spine surgery by pregabalin and celecoxib: a prospective study

Kien NT, Geiger P, Van Chuong H, Cuong NM, Van Dinh N, Pho DC, Anh VT, Giang NT

Drug Design, Development and Therapy 2019, 13:2145-2152

Published Date: 3 July 2019

Role of GRP78 inhibiting artesunate-induced ferroptosis in KRAS mutant pancreatic cancer cells

Wang K, Zhang Z, Wang M, Cao X, Qi J, Wang D, Gong A, Zhu H

Drug Design, Development and Therapy 2019, 13:2135-2144

Published Date: 2 July 2019

Ginsenoside Rb1 pretreatment reverses hippocampal changes in BDNF/TrkB mRNA and protein in rats subjected to acute immobilization stress

Kang X, Hong W, Xie K, Tang H, Tang J, Luo S, Geng W, Jia D

Drug Design, Development and Therapy 2019, 13:2127-2134

Published Date: 1 July 2019

Phosphocreatine attenuates Gynura segetum-induced hepatocyte apoptosis via a SIRT3-SOD2-mitochondrial reactive oxygen species pathway

Li DP, Chen YL, Jiang HY, Chen Y, Zeng XQ, Xu LL, Ye Y, Ke CQ, Lin G, Wang JY, Gao H

Drug Design, Development and Therapy 2019, 13:2081-2096

Published Date: 27 June 2019

Dexmedetomidine protects PC12 cells from lidocaine-induced cytotoxicity via downregulation of Stathmin 1

Tan Y, Bi X, Wang Q, Li Y, Zhang N, Lao J, Liu X

Drug Design, Development and Therapy 2019, 13:2067-2079

Published Date: 3 July 2019

Ginsenoside Rg3 protects mouse leydig cells against triptolide by downregulation of miR-26a

Liang H, Zhang S, Li Z

Drug Design, Development and Therapy 2019, 13:2057-2066

Published Date: 24 June 2019

A novel mutation panel for predicting etoposide resistance in small-cell lung cancer

Qiu Z, Lin A, Li K, Lin W, Wang Q, Wei T, Zhu W, Luo P, Zhang J

Drug Design, Development and Therapy 2019, 13:2021-2041

Published Date: 21 June 2019

TMF inhibits miR-29a/Wnt/β-catenin signaling through upregulating Foxo3a activity in osteoarthritis chondrocytes

Huang X, Chen Z, Shi W, Zhang R, Li L, Liu H, Wu L

Drug Design, Development and Therapy 2019, 13:2009-2019

Published Date: 19 June 2019

Evaluating guselkumab: an anti-IL-23 antibody for the treatment of plaque psoriasis

Yang EJ, Smith MP, Ly K, Bhutani T

Drug Design, Development and Therapy 2019, 13:1993-2000

Published Date: 18 June 2019

Efficacy and safety of total glucosides of paeony combined with methotrexate and leflunomide for active rheumatoid arthritis: a meta-analysis

Huang Y, Wang H, Chen Z, Wang Y, Qin K, Huang Y, Ba X, Lin W, Tu S

Drug Design, Development and Therapy 2019, 13:1969-1984

Published Date: 17 June 2019

The neuroprotective effect of bisperoxovandium (pyridin-2-squaramide) in intracerebral hemorrhage

Liao XY, Lei Y, Chen SF, Cheng J, Zhao D, Zhang ZF, Han X, Zhang Y, Liao HB, Zhuang Y, Chen J, Zhou HB, Wan Q, Zou YY

Drug Design, Development and Therapy 2019, 13:1957-1967

Published Date: 13 June 2019

Solutol®HS15+pluronicF127 and Solutol®HS15+pluronicL61 mixed micelle systems for oral delivery of genistein

Ding P, Chen Y, Cao G, Shen H, Ju J, Li W

Drug Design, Development and Therapy 2019, 13:1947-1956

Published Date: 7 June 2019

Notopterol-induced apoptosis and differentiation in human acute myeloid leukemia HL-60 cells

Huang Q, Wang L, Ran Q, Wang J, Wang C, He H, Li L, Qi H

Drug Design, Development and Therapy 2019, 13:1927-1940

Published Date: 6 June 2019

Decreased sEng plasma levels in hypertensive patients with endothelial dysfunction under chronic treatment with Perindopril

Buda V, Andor M, Baibata DE, Cozlac R, Radu G, Coricovac D, Danciu C, Ledeti I, Cheveresan A, Nica C, Tuduce P, Tomescu MC

Drug Design, Development and Therapy 2019, 13:1915-1925

Published Date: 4 June 2019

Effects of Qi Teng Xiao Zhuo granules on circRNA expression profiles in rats with chronic glomerulonephritis

Gao JR, Jiang NN, Jiang H, Wei LB, Gao YC, Qin XJ, Zhu MQ, Wang J

Drug Design, Development and Therapy 2019, 13:1901-1913

Published Date: 4 June 2019

Efficacy and toxicity of cladribine for the treatment of refractory acute myeloid leukemia: a meta-analysis

Zhou A, Han Q, Song H, Zi J, Ma J, Ge Z

Drug Design, Development and Therapy 2019, 13:1867-1878

Published Date: 29 May 2019

Therapeutic potential of pravastatin for random skin flaps necrosis: involvement of promoting angiogenesis and inhibiting apoptosis and oxidative stress [Corrigendum]

Lin J, Jia C, Wang Y, Jiang S, Jia Z, Chen N, Sheng S, Li S, Jiang L, Xu H, Zhou K, Chen Y

Drug Design, Development and Therapy 2019, 13:1865-1866

Published Date: 29 May 2019

Use of lidocaine to prevent postoperative coughing after partial laryngectomy: comparison of three delivery methods

Wang Y, Lu WS, Qiao H, Zhao J, Fan Q

Drug Design, Development and Therapy 2019, 13:1835-1841

Published Date: 27 May 2019

A novel non-invasive monitoring assay of 5-azacitidine efficacy using global DNA methylation of peripheral blood in myelodysplastic syndrome

Asano M, Ohyashiki JH, Kobayashi-Kawana C, Umezu T, Imanishi S, Azuma K, Akahane D, Fujimoto H, Ito Y, Ohyashiki K

Drug Design, Development and Therapy 2019, 13:1821-1833

Published Date: 30 May 2019

Ferulic acid attenuates liver fibrosis and hepatic stellate cell activation via inhibition of TGF-β/Smad signaling pathway [Corrigendum]

Mu M, Zuo S, Wu RM, Deng KS, Lu S, Zhu JJ, Zou GL, Yang J, Cheng ML, Zhao XK

Drug Design, Development and Therapy 2019, 13:1819-1820

Published Date: 24 May 2019

Frequency, clinical features and differential response to therapy of concurrent ALK/EGFR alterations in Chinese lung cancer patients

Liu J, Mu Z, Liu L, Li K, Jiang R, Chen P, Zhou Q, Jin M, Ma Y, Xie Y, Xiang J, Li B, Ma Y, Mao X, Zhang L, Zhang T, Wu D

Drug Design, Development and Therapy 2019, 13:1809-1817

Published Date: 23 May 2019

Effect of dexmedetomidine on etomidate-induced myoclonus: a randomized, double-blind controlled trial

Miao S, Zou L, Wang G, Wang X, Liu S, Shi M

Drug Design, Development and Therapy 2019, 13:1803-1808

Published Date: 27 May 2019

Low-dose doxycycline inhibits hydrogen peroxide-induced oxidative stress, MMP-2 up-regulation and contractile dysfunction in human saphenous vein grafts

Saeed M, Arun MZ, Guzeloglu M, Onursal C, Gokce G, Korkmaz CG, Reel B

Drug Design, Development and Therapy 2019, 13:1791-1801

Published Date: 23 May 2019

Synthesis, comparative docking, and pharmacological activity of naproxen amino acid derivatives as possible anti-inflammatory and analgesic agents

Elhenawy AA, Al-Harbi LM, Moustafa GO, El-Gazzar MA, Abdel-Rahman RF, Salim AE

Drug Design, Development and Therapy 2019, 13:1773-1790

Published Date: 24 May 2019

SU5416 attenuated lipopolysaccharide-induced acute lung injury in mice by modulating properties of vascular endothelial cells

Huang X, Zhu J, Jiang Y, Xu C, Lv Q, Yu D, Shi K, Ruan Z, Wang Y

Drug Design, Development and Therapy 2019, 13:1763-1772

Published Date: 23 May 2019

Population pharmacokinetic analysis of tramadol and O-desmethyltramadol with genetic polymorphism of CYP2D6

Lee J, Yoo H, Bae JW, Lee S, Shin K

Drug Design, Development and Therapy 2019, 13:1751-1761

Published Date: 23 May 2019

The effect of midazolam administration for the prevention of emergence agitation in pediatric patients with extreme fear and non-cooperation undergoing dental treatment under sevoflurane anesthesia, a double-blind, randomized study

Kawai M, Kurata S, Sanuki T, Mishima G, Kiriishi K, Watanabe T, Ozaki-Honda Y, Yoshida M, Okayasu I, Ayuse T, Tanoue N, Ayuse T

Drug Design, Development and Therapy 2019, 13:1729-1737

Published Date: 17 May 2019

Genetic variations in the transcription factors GATA4 and GATA6 and bleeding complications in patients receiving warfarin therapy

Yee J, Kim W, Chang BC, Chung JE, Lee KE, Gwak HS

Drug Design, Development and Therapy 2019, 13:1717-1727

Published Date: 17 May 2019

Sevoflurane post-conditioning alleviates neonatal rat hypoxic-ischemic cerebral injury via Ezh2-regulated autophagy

Xue H, Xu Y, Wang S, Wu ZY, Li XY, Zhang YH, Niu JY, Gao QS, Zhao P

Drug Design, Development and Therapy 2019, 13:1691-1706

Published Date: 15 May 2019

Efficacy of a recombinant single-chain fragment variable region, VasSF, as a new drug for vasculitis [Corrigendum]

Kameoka Y, Kishi F, Koura M, Yamakawa Y, Nagasawa R, Ito F, Matsuda J, Suzuki O, Nakayama T, Suzuki K

Drug Design, Development and Therapy 2019, 13:1689-1690

Published Date: 22 May 2019

Cardiovascular adverse events during treatment with darunavir-based regimens in an Italian observational study

Antinori A, Rusconi S, Gianotti N, Bini T, Mancusi D, Termini R

Drug Design, Development and Therapy 2019, 13:1667-1685

Published Date: 14 May 2019

Dexibuprofen amide derivatives as potential anticancer agents: synthesis, in silico docking, bioevaluation, and molecular dynamic simulation

Ashraf Z, Mahmood T, Hassan M, Afzal S, Rafique H, Afzal K, Latip J

Drug Design, Development and Therapy 2019, 13:1643-1657

Published Date: 14 May 2019

Pharmacokinetics of fixed-dose combination of atorvastatin and metformin compared with individual tablets

Ghim JL, Phuong NTT, Kim MJ, Kim EJ, Song GS, Ahn S, Shin JG, Kim EY

Drug Design, Development and Therapy 2019, 13:1623-1632

Published Date: 13 May 2019

Formulation and evaluation of simvastatin polymeric nanoparticles loaded in hydrogel for optimum wound healing purpose

Farghaly Aly U, Abou-Taleb HA, Abdellatif AH, Sameh Tolba N

Drug Design, Development and Therapy 2019, 13:1567-1580

Published Date: 10 May 2019

In silico and in vitro studies of lupeol and iso-orientin as potential antidiabetic agents in a rat model

Malik A, Jamil U, Butt TT, Waquar S, Gan SH, Shafique H, Jafar TH

Drug Design, Development and Therapy 2019, 13:1501-1513

Published Date: 6 May 2019

Resveratrol reduces liver endoplasmic reticulum stress and improves insulin sensitivity in vivo and in vitro

Zhao H, Zhang Y, Shu L, Song G, Ma H

Drug Design, Development and Therapy 2019, 13:1473-1485

Published Date: 2 May 2019

Therapeutic potential of pravastatin for random skin flaps necrosis: involvement of promoting angiogenesis and inhibiting apoptosis and oxidative stress

Lin J, Jia C, Wang Y, Jiang S, Jia Z, Chen N, Sheng S, Li S, Jiang L, Xu H, Zhou K, Chen Y

Drug Design, Development and Therapy 2019, 13:1461-1472

Published Date: 1 May 2019

Synthesis of a vanadyl (IV) folate complex for the treatment of diabetes: spectroscopic, structural, and biological characterization

Naglah AM, Refat MS, Al-Omar MA, Bhat MA, AlKahtani HM, Al-Wasidi AS

Drug Design, Development and Therapy 2019, 13:1409-1420

Published Date: 30 April 2019

The TwistDock workflow for evaluation of bivalent Smac mimetics targeting XIAP

Huang Q, Peng Y, Peng Y, Wei D, Wei Y, Feng S

Drug Design, Development and Therapy 2019, 13:1373-1388

Published Date: 26 April 2019

Codelivery of GRP78 siRNA and docetaxel via RGD-PEG-DSPE/DOPA/CaP nanoparticles for the treatment of castration-resistant prostate cancer

Zhang X, He Z, Xiang L, Li L, Zhang H, Lin F, Cao H

Drug Design, Development and Therapy 2019, 13:1357-1372

Published Date: 29 April 2019

Clinical efficacy of 60-mg dexlansoprazole and 40-mg esomeprazole after 24 weeks for the on-demand treatment of gastroesophageal reflux disease grades A and B: a prospective randomized trial

Chiang HH, Wu DC, Hsu PI, Kuo CH, Tai WC, Yang SC, Wu KL, Yao CC, Tsai CE, Liang CM, Wang YK, Wang JW, Huang CF, Chuah SK

Drug Design, Development and Therapy 2019, 13:1347-1356

Published Date: 26 April 2019

Caffeic acid phenethyl ester suppressed growth and metastasis of nasopharyngeal carcinoma cells by inactivating the NF-κB pathway

Liang Y, Feng G, Wu L, Zhong S, Gao X, Tong Y, Cui W, Qin Y, Xu WQ, Xiao X, Zhang Z, Huang G, Zhou X

Drug Design, Development and Therapy 2019, 13:1335-1345

Published Date: 26 April 2019

Epigallocatechin-3-gallate enhances the osteoblastogenic differentiation of human adipose-derived stem cells

Zhang J, Wu K, Xu T, Wu J, Li P, Wang H, Wu H, Wu G

Drug Design, Development and Therapy 2019, 13:1311-1321

Published Date: 23 April 2019

Effects of dezocine for the prevention of postoperative catheter-related bladder discomfort: a prospective randomized trial

Zhang GF, Guo J, Qiu LL, Li SM, Zheng M, Xia JY, Yang JJ

Drug Design, Development and Therapy 2019, 13:1281-1288

Published Date: 23 April 2019

Pharmacokinetics and pharmacodynamics of the novel Nrf2 activator omaveloxolone in primates

Reisman SA, Gahir SS, Lee CY, Proksch JW, Sakamoto M, Ward KW

Drug Design, Development and Therapy 2019, 13:1259-1270

Published Date: 17 April 2019

The molecular mechanisms of Aloin induce gastric cancer cells apoptosis by targeting High Mobility Group Box 1

Tao H, Tang T, Wang S, Wang Z, Ma Y, Cai T, Cheng X, Qi S, Zhang Y, Qi Z

Drug Design, Development and Therapy 2019, 13:1221-1231

Published Date: 17 April 2019

Effect of butorphanol on etomidate-induced myoclonus: a systematic review and meta-analysis

Hua J, Miao S, Shi M, Tu Q, Wang X, Liu S, Wang G, Gan J

Drug Design, Development and Therapy 2019, 13:1213-1220

Published Date: 16 April 2019

Beneficial effects of resveratrol and exercise training on cardiac and aortic function and structure in the 3xTg mouse model of Alzheimer’s disease

Esfandiarei M, Hoxha B, Talley NA, Anderson MR, Alkhouli MF, Squire MA, Eckman DM, Babu JR, Lopaschuk GD, Broderick TL

Drug Design, Development and Therapy 2019, 13:1197-1211

Published Date: 17 April 2019

Tetramethylpyrazine attenuated bupivacaine-induced neurotoxicity in SH-SY5Y cells through regulating apoptosis, autophagy and oxidative damage

Wang S, Xia B, Qiao Z, Duan L, Wang G, Meng W, Liu Z, Wang Y, Zhang M

Drug Design, Development and Therapy 2019, 13:1187-1196

Published Date: 17 April 2019

Effect of umbelliferone on adjuvant-induced arthritis in rats by MAPK/NF-κB pathway

Ouyang L, Dan Y, Shao Z, Yang S, Yang C, Liu G, Zhou W, Duan D

Drug Design, Development and Therapy 2019, 13:1163-1170

Published Date: 11 April 2019

Quizartinib (AC220): a promising option for acute myeloid leukemia

Zhou F, Ge Z, Chen B

Drug Design, Development and Therapy 2019, 13:1117-1125

Published Date: 8 April 2019

A novel hybrid compound LLP2A-alendronate accelerates open fracture healing in a rabbit model

Wang Z, Zhao Y, Zhang D, Qi B, Xiao W, Hu X, Yu A

Drug Design, Development and Therapy 2019, 13:1077-1086

Published Date: 5 April 2019

Systematic elucidation of the mechanism of geraniol via network pharmacology

Zhang YF, Huang Y, Ni YH, Xu ZM

Drug Design, Development and Therapy 2019, 13:1069-1075

Published Date: 4 April 2019

Transportan-derived cell-penetrating peptide delivers siRNA to inhibit replication of influenza virus in vivo

Zhang C, Ren W, Liu Q, Tan Z, Li J, Tong C

Drug Design, Development and Therapy 2019, 13:1059-1068

Published Date: 4 April 2019

Formulation and bioequivalence studies of choline alfoscerate tablet comparing with soft gelatin capsule in healthy male volunteers

Min MH, Park JH, Hur JH, Shin HC, Cho YJ, Kim DD

Drug Design, Development and Therapy 2019, 13:1049-1058

Published Date: 5 April 2019

Metabolism of remimazolam in primary human hepatocytes during continuous long-term infusion in a 3-D bioreactor system

Freyer N, Knöspel F, Damm G, Greuel S, Schneider C, Seehofer D, Stöhr T, Petersen KU, Zeilinger K

Drug Design, Development and Therapy 2019, 13:1033-1047

Published Date: 2 April 2019

Jinlong capsule inhibits migration and invasion in human glioblastoma cells via the modulation of mTOR/S6 signaling pathway

Shi J, Zhang W, He L, Kong F, Pan M, Guo J, Xu X, Guo J, Wang H, Wang Y

Drug Design, Development and Therapy 2019, 13:1023-1032

Published Date: 1 April 2019

Efficacy and safety of paricalcitol in patients undergoing hemodialysis: a meta-analysis

Liu Y, Liu LY, Jia Y, Wu MY, Sun YY, Ma FZ

Drug Design, Development and Therapy 2019, 13:999-1009

Published Date: 28 March 2019

Emodin alleviates myocardial ischemia/reperfusion injury by inhibiting gasdermin D-mediated pyroptosis in cardiomyocytes

Ye B, Chen X, Dai S, Han J, Liang X, Lin S, Cai X, Huang Z, Huang W

Drug Design, Development and Therapy 2019, 13:975-990

Published Date: 25 March 2019

Mechanistic research holds promise for bacterial vaccines and phage therapies for Pseudomonas aeruginosa

Hoggarth A, Weaver A, Pu Q, Huang T, Schettler J, Chen F, Yuan X, Wu M

Drug Design, Development and Therapy 2019, 13:909-924

Published Date: 20 March 2019

Protective role of quercetin against manganese-induced injury in the liver, kidney, and lung; and hematological parameters in acute and subchronic rat models [Retraction]

Bahar E, Lee GH, Bhattarai KR, Lee HY, Kim HK, Handigund M, Choi MK, Han SY, Chae HJ, Yoon H

Drug Design, Development and Therapy 2019, 13:907-908

Published Date: 18 March 2019

Drug-release system of microchannel transport used in minimally invasive surgery for hemostasis

Huang H, Liu H, Zhou H, Liang Z, Song D, Zhang Y, Huang W, Zhao X, Wu B, Ye G, Huang Y

Drug Design, Development and Therapy 2019, 13:881-896

Published Date: 12 March 2019

Efficacy and safety of tacrolimus in induction therapy of patients with lupus nephritis

Zhou TB, Lin SJ, Yang S, Lin WS

Drug Design, Development and Therapy 2019, 13:857-869

Published Date: 12 March 2019

Clinical efficacy and safety of rituximab in lupus nephritis

Zhong Z, Li H, Zhong H, Zhou T

Drug Design, Development and Therapy 2019, 13:845-856

Published Date: 11 March 2019

Single-use suvorexant for treating insomnia during overnight polysomnography in patients with suspected obstructive sleep apnea: a single-center experience

Matsumura T, Terada J, Yoshimura C, Koshikawa K, Kinoshita T, Yahaba M, Nagashima K, Sakao S, Tatsumi K

Drug Design, Development and Therapy 2019, 13:809-816

Published Date: 28 February 2019

Utility of nintedanib for severe idiopathic pulmonary fibrosis: a single-center retrospective study [Corrigendum]

Abe M, Tsushima K, Sakayori M, Suzuki K, Ikari J, Terada J, Tatsumi K

Drug Design, Development and Therapy 2019, 13:807-808

Published Date: 28 February 2019

Physicochemical characterization and phase I study of CMAB008, an infliximab biosimilar produced by a different expression system

An Q, Zheng Y, Zhao Y, Liu T, Guo H, Zhang D, Qian W, Wang H, Guo Y, Hou S, Li J

Drug Design, Development and Therapy 2019, 13:791-805

Published Date: 12 March 2019

Synthesis, structure elucidation, and antifungal potential of certain new benzodioxole–imidazole molecular hybrids bearing ester functionalities

Al-Wabli RI, Al-Ghamdi AR, Ghabbour HA, Al-Agamy MH, Attia MI

Drug Design, Development and Therapy 2019, 13:775-789

Published Date: 26 February 2019

Ginkgolide B ameliorates myocardial ischemia reperfusion injury in rats via inhibiting endoplasmic reticulum stress

Guo C, Zhang J, Zhang P, Si A, Zhang Z, Zhao L, Lv F, Zhao G

Drug Design, Development and Therapy 2019, 13:767-774

Published Date: 26 February 2019

Monosialoganglioside protects against bupivacaine-induced neurotoxicity caused by endoplasmic reticulum stress in rats

Liu B, Ji J, Feng Q, Luo X, Yan X, Ni Y, He Y, Mao Z, Liu J

Drug Design, Development and Therapy 2019, 13:707-718

Published Date: 19 February 2019

Dexmedetomidine attenuates the neurotoxicity of propofol toward primary hippocampal neurons in vitro via Erk1/2/CREB/BDNF signaling pathways

Tu Y, Liang Y, Xiao Y, Lv J, Guan R, Xiao F, Xie Y, Xiao Q

Drug Design, Development and Therapy 2019, 13:695-706

Published Date: 19 February 2019

Synthesis of budesonide conjugates and their anti-inflammatory effects: a preliminary study

Yan Y, Wang P, Li R, Sun Y, Zhang R, Huo C, Xing J, Dong Y

Drug Design, Development and Therapy 2019, 13:681-694

Published Date: 19 February 2019

Update in treatment of uveitic macular edema

Koronis S, Stavrakas P, Balidis M, Kozeis N, Tranos PG

Drug Design, Development and Therapy 2019, 13:667-680

Published Date: 19 February 2019

Ginkgo biloba extract-761 protects myocardium by regulating Akt/Nrf2 signal pathway

Chen X, Ren S, Dong J, Qiu C, Chen Y, Tao H

Drug Design, Development and Therapy 2019, 13:647-655

Published Date: 13 February 2019

Epigallocatechin-3-gallate in the prevention and treatment of hepatocellular carcinoma: experimental findings and translational perspectives

Bimonte S, Albino V, Piccirillo M, Nasto A, Molino C, Palaia R, Cascella M

Drug Design, Development and Therapy 2019, 13:611-621

Published Date: 12 February 2019

Emodin induces apoptosis and autophagy of fibroblasts obtained from patient with ankylosing spondylitis

Ma C, Wen B, Zhang Q, Shao P, Gu W, Qu K, Shi Y, Wang B

Drug Design, Development and Therapy 2019, 13:601-609

Published Date: 11 February 2019

The underlying mechanisms of Jie-Du-Hua-Yu granule for protecting rat liver failure

Qiu H, Mao D, Tang N, Long F, Zhang R, Wang M, Shi Q, Li J, Jiang Q, Chen Y, Wang X

Drug Design, Development and Therapy 2019, 13:589-600

Published Date: 11 February 2019

Cathepsin G cleaves and activates IL-36γ and promotes the inflammation of psoriasis

Guo J, Tu J, Hu YY, Song GX, Yin ZQ

Drug Design, Development and Therapy 2019, 13:581-588

Published Date: 8 February 2019

Efficacy of a recombinant single-chain fragment variable region, VasSF, as a new drug for vasculitis

Kameoka Y, Kishi F, Koura M, Yamakawa Y, Nagasawa R, Ito F, Matsuda J, Suzuki O, Nakayama T, Suzuki K

Drug Design, Development and Therapy 2019, 13:555-568

Published Date: 5 February 2019

The benefit of taxane-based therapies over fluoropyrimidine plus platinum (FP) in the treatment of esophageal cancer: a meta-analysis of clinical studies

Wang T, Yu J, Liu M, Chen Y, Zhu C, Lu L, Wang M, Min L, Liu X, Zhang X, Gubat JA, Chen Y

Drug Design, Development and Therapy 2019, 13:539-553

Published Date: 5 February 2019

Safety and efficacy of atezolizumab in the treatment of cancers: a systematic review and pooled-analysis

Tie Y, Yang H, Zhao R, Zheng H, Yang D, Zhao J, Liu M

Drug Design, Development and Therapy 2019, 13:523-538

Published Date: 4 February 2019

Bisperoxovanadium protects against spinal cord injury by regulating autophagy via activation of ERK1/2 signaling

Tang Y, Li K, Yang C, Huang K, Zhou J, Shi Y, Xie K, Liu J

Drug Design, Development and Therapy 2019, 13:513-521

Published Date: 1 February 2019

A nucleoside-sparing regimen of dolutegravir plus ritonavir-boosted atazanavir in HIV-1-infected patients with virological failure: the DOLATAV study

Spagnuolo V, Galli L, Poli A, Bigoloni A, Fumagalli L, Gianotti N, Nozza S, Ferrari D, Locatelli M, Lazzarin A, Castagna A

Drug Design, Development and Therapy 2019, 13:477-479

Published Date: 24 January 2019

Qingxin kaiqiao fang ameliorates memory impairment and inhibits apoptosis in APP/PS1 double transgenic mice through the MAPK pathway

Gao SY, Lin J, Wang T, Shen Y, Li Y, Yang W, Zhou K, Hu H

Drug Design, Development and Therapy 2019, 13:459-475

Published Date: 23 January 2019

Structure–activity relationship of an antimicrobial peptide, Phylloseptin-PHa: balance of hydrophobicity and charge determines the selectivity of bioactivities

Liu Y, Du Q, Ma C, Xi X, Wang L, Zhou M, Burrows JF, Chen T, Wang H

Drug Design, Development and Therapy 2019, 13:447-458

Published Date: 23 January 2019

MicroRNA-339 inhibits human hepatocellular carcinoma proliferation and invasion via targeting ZNF689

Zeng H, Zheng J, Wen S, Luo J, Shao G, Zhang Y

Drug Design, Development and Therapy 2019, 13:435-445

Published Date: 22 January 2019

Design, synthesis, and biologic evaluation of novel chrysin derivatives as cytotoxic agents and caspase-3/7 activators

Al-Oudat BA, Alqudah MA, Audat SA, Al-Balas QA, El-Elimat T, Hassan MA, Frhat IN, Azaizeh MM

Drug Design, Development and Therapy 2019, 13:423-433

Published Date: 22 January 2019

A real-life experience of sorafenib treatment for patients with advanced hepatocellular carcinoma: a retrospective analysis at Cathay General Hospital, 2007–2015

Huang CC, Chen HY, Chang RH, Liao PA, Lien HH, Hung CS, Yang SS, Hu JT

Drug Design, Development and Therapy 2019, 13:397-404

Published Date: 22 January 2019

Screening of novel HSP-inducing compounds to conserve cardiomyocyte function in experimental atrial fibrillation

van Marion DMS, Hu X, Zhang D, Hoogstra-Berends F, Seerden JPG, Loen L, Heeres A, Steen H, Henning RH, Brundel BJJM

Drug Design, Development and Therapy 2019, 13:345-364

Published Date: 18 January 2019

YB-1 modulates the drug resistance of glioma cells by activation of MDM2/p53 pathway

Tong H, Zhao K, Zhang J, Zhu J, Xiao J

Drug Design, Development and Therapy 2019, 13:317-326

Published Date: 14 January 2019

A brief report of toxicity end points of HER2 vaccines for the treatment of patients with HER2+ breast cancer

Costa R, Zaman S, Sharpe S, Helenowski I, Shaw C, Han H, Soliman H, Czerniecki B

Drug Design, Development and Therapy 2019, 13:309-316

Published Date: 14 January 2019

Antistaphylococcal evaluation of indole–naphthalene hybrid analogs

Ashraf K, Yasrebi K, Adeniyi ET, Hertlein T, Ohlsen K, Lalk M, Erdmann F, Hilgeroth A

Drug Design, Development and Therapy 2019, 13:275-283

Published Date: 10 January 2019

Catalpol prevents denervated muscular atrophy related to the inhibition of autophagy and reduces BAX/BCL2 ratio via mTOR pathway

Wang Y, Shao YL, Gao YQ, Wan GR, Wan D, Zhu HF, Qiu Y, Ye XY

Drug Design, Development and Therapy 2019, 13:243-253

Published Date: 31 December 2018

A colon-specific prodrug of metoclopramide ameliorates colitis in an experimental rat model

Yang Y, Kim W, Kim D, Jeong S, Yoo JW, Jung Y

Drug Design, Development and Therapy 2019, 13:231-242

Published Date: 28 December 2018

Xyloketal derivative C53N protects against mild traumatic brain injury in mice

Liang F, Su F, Wang X, Long S, Zheng Y, He X, Pang J, Pei Z

Drug Design, Development and Therapy 2019, 13:173-182

Published Date: 27 December 2018

Urapidil, compared to nitroglycerin, has better clinical safety in the treatment of hypertensive patients with acute heart failure: a meta-analysis

Shi J, Li Y, Xing C, Peng P, Shi H, Ding H, Zheng P, Ning G, Feng S

Drug Design, Development and Therapy 2019, 13:161-172

Published Date: 27 December 2018

Fenofibrate modified-release pellets with lag phase and high oral bioavailability

Li F, Zheng X, Bao YC, Chen T, Zeng J, Xu XL, Yan C, Feng LL

Drug Design, Development and Therapy 2019, 13:141-151

Published Date: 24 December 2018

Tetrandrine suppresses cervical cancer growth by inducing apoptosis in vitro and in vivo

Zhang H, Xie B, Zhang Z, Sheng X, Zhang S

Drug Design, Development and Therapy 2019, 13:119-127

Published Date: 20 December 2018

Tocilizumab in the treatment of rheumatoid arthritis: an evidence-based review and patient selection

Biggioggero M, Crotti C, Becciolini A, Favalli EG

Drug Design, Development and Therapy 2019, 13:57-70

Published Date: 19 December 2018

Ocular side effects of levitra® (vardenafil) – results of a double-blind crossover study in healthy male subjects

Roessler G, Vobig M, Walter P, Mazinani BAE

Drug Design, Development and Therapy 2019, 13:37-43

Published Date: 18 December 2018

Multimetal organic frameworks as drug carriers: aceclofenac as a drug candidate

Al Haydar M, Abid HR, Sunderland B, Wang S

Drug Design, Development and Therapy 2019, 13:23-35

Published Date: 18 December 2018

Cytoprotective effects of molsidomine against methotrexate-induced hepatotoxicity: an experimental rat study

Samdanci ET, Huz M, Ozhan O, Tanbek K, Pamukcu E, Akatli AN, Parlakpinar H

Drug Design, Development and Therapy 2019, 13:13-21

Published Date: 20 December 2018

3-n-butylphthalide exerts neuroprotective effects by enhancing anti-oxidation and attenuating mitochondrial dysfunction in an in vitro model of ischemic stroke

Chen N, Zhou Z, Li J, Li B, Feng J, He D, Luo Y, Zheng X, Luo J, Zhang J

Drug Design, Development and Therapy 2018, 12:4261-4271

Published Date: 14 December 2018

MMI-0100 ameliorates lung inflammation in a mouse model of acute respiratory distress syndrome by reducing endothelial expression of ICAM-1

He B, Geng S, Zhou W, Rui Y, Mu X, Zhang C, You Q, Su X

Drug Design, Development and Therapy 2018, 12:4253-4260

Published Date: 13 December 2018

Gamma linolic acid regulates PHD2 mediated hypoxia and mitochondrial apoptosis in DEN induced Hepatocellular carcinoma

Cui H, Han F, Zhang L, Wang L, Kumar M

Drug Design, Development and Therapy 2018, 12:4241-4252

Published Date: 13 December 2018

Iron oxide nanoparticles as nanocarriers to improve chlorin e6-based sonosensitivity in sonodynamic therapy

Zhang P, Ren Z, Chen Z, Zhu J, Liang J, Liao R, Wen J

Drug Design, Development and Therapy 2018, 12:4207-4216

Published Date: 10 December 2018

Recent development in the strategies projected for chikungunya vaccine in humans

Goyal M, Chauhan A, Goyal V, Jaiswal N, Singh S, Singh M

Drug Design, Development and Therapy 2018, 12:4195-4206

Published Date: 10 December 2018

ADAR1 silencing-induced HUVEC apoptosis is mediated by FGFR2 under hypoxia stress

Jiang Y, Wang Z, Chen X, Wang W, Wang X

Drug Design, Development and Therapy 2018, 12:4181-4189

Published Date: 10 December 2018

Best tigecycline dosing for treatment of infections caused by multidrug-resistant pathogens in critically ill patients with different body weights

Ibrahim MM, Abuelmatty AM, Mohamed GH, Nasr MA, Hussein AK, Ebaed MED, Sarhan HA

Drug Design, Development and Therapy 2018, 12:4171-4179

Published Date: 7 December 2018

SREBP-2, a new target of metformin?

Zhang F, Sun W, Chen J, Jiang L, Yang P, Huang Y, Gong A, Liu S, Ma S

Drug Design, Development and Therapy 2018, 12:4163-4170

Published Date: 6 December 2018

Quercetin inhibits transforming growth factor β1-induced epithelial–mesenchymal transition in human retinal pigment epithelial cells via the Smad pathway

Cai W, Yu D, Fan J, Liang X, Jin H, Liu C, Zhu M, Shen T, Zhang R, Hu W, Wei Q, Yu J

Drug Design, Development and Therapy 2018, 12:4149-4161

Published Date: 6 December 2018

Synthesis of small peptide compounds, molecular docking, and inhibitory activity evaluation against phosphatases PTP1B and SHP2

Kostrzewa T, Sahu KK, Gorska-Ponikowska M, Tuszynski JA, Kuban-Jankowska A

Drug Design, Development and Therapy 2018, 12:4139-4147

Published Date: 5 December 2018

The role of various transporters in the placental uptake of ofloxacin in an in vitro model of human villous trophoblasts

Polachek H, Debotton N, Feinshtein V, Rubin M, Ben-Zvi Z, Holcberg G, Agbaria R, Dahan A

Drug Design, Development and Therapy 2018, 12:4129-4138

Published Date: 4 December 2018

N-acetylcysteine amide provides neuroprotection via Nrf2-ARE pathway in a mouse model of traumatic brain injury

Zhou Y, Wang HD, Zhou XM, Fang J, Zhu L, Ding K

Drug Design, Development and Therapy 2018, 12:4117-4127

Published Date: 4 December 2018

Ferulic acid attenuates liver fibrosis and hepatic stellate cell activation via inhibition of TGF-β/Smad signaling pathway

Mu M, Zuo S, Wu RM, Deng KS, Lu S, Zhu JJ, Zou GL, Yang J, Cheng ML, Zhao XK

Drug Design, Development and Therapy 2018, 12:4107-4115

Published Date: 3 December 2018

The synergistic effect of 2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-glucoside combined with Adriamycin on MCF-7 breast cancer cells

Shen JF, Zhang YZ, Shen H, Pan H, Xu LS, Yuan LN, Ding ZY

Drug Design, Development and Therapy 2018, 12:4083-4094

Published Date: 30 November 2018

Beraprost sodium preconditioning prevents inflammation, apoptosis, and autophagy during hepatic ischemia-reperfusion injury in mice via the P38 and JNK pathways

Deng J, Feng J, Liu T, Lu X, Wang W, Liu N, Lv Y, Liu Q, Guo C, Zhou Y

Drug Design, Development and Therapy 2018, 12:4067-4082

Published Date: 29 November 2018

Spotlight on inhaled ciprofloxacin and its potential in the treatment of non-cystic fibrosis bronchiectasis

Chorepsima S, Kechagias KS, Kalimeris G, Triarides NA, Falagas ME

Drug Design, Development and Therapy 2018, 12:4059-4066

Published Date: 27 November 2018

Pharmacokinetics of single- and multiple-dose roflumilast: an open-label, three-way crossover study in healthy Chinese volunteers

Huang J, Fu CX, Yang XY, Cui C, Yang S, Kuang Y, Guo CX, Hu P, Pei Q, Yang GP

Drug Design, Development and Therapy 2018, 12:4047-4057

Published Date: 26 November 2018

Schisandrin B elicits the Keap1-Nrf2 defense system via carbene reactive metabolite which is less harmful to mice liver

Feng S, Qiu B, Zou L, Liu K, Xu X, Zhu H

Drug Design, Development and Therapy 2018, 12:4033-4046

Published Date: 23 November 2018

Icariin promotes the migration of bone marrow stromal cells via the SDF-1α/HI F-1α/CXCR 4 pathway

Zhu H, Wang X, Han Y, Zhang W, Xin W, Zheng X, Zhang J

Drug Design, Development and Therapy 2018, 12:4023-4031

Published Date: 22 November 2018

Schisandrin B protects against angiotensin II-induced endotheliocyte deficits by targeting Keap1 and activating Nrf2 pathway

Han J, Shi X, Zheng Z, Zhang B, Shi F, Jiang L, Xu J

Drug Design, Development and Therapy 2018, 12:3985-3997

Published Date: 22 November 2018

Valproic acid enhances the viability of random pattern skin flaps: involvement of enhancing angiogenesis and inhibiting oxidative stress and apoptosis

Wu H, Ding J, Wang L, Lin J, Li S, Xiang G, Jiang L, Xu H, Gao W, Zhou K

Drug Design, Development and Therapy 2018, 12:3951-3960

Published Date: 16 November 2018

Gene transfer to rat cerebral cortex mediated by polysorbate 80 and poloxamer 188 nonionic surfactant vesicles

Attia N, Mashal M, Soto-Sánchez C, Martinez-Navarrete G., Fernández E, Grijalvo S, Eritja R, Puras G, Pedraz JL

Drug Design, Development and Therapy 2018, 12:3937-3949

Published Date: 16 November 2018

Arsenic sulfide amplifies JQ1 toxicity via mitochondrial pathway in gastric and colon cancer cells

Tan Z, Zhang X, Kang T, Zhang L, Chen S

Drug Design, Development and Therapy 2018, 12:3913-3927

Published Date: 14 November 2018

A study on screening and antitumor effect of CD55-specific ligand peptide in cervical cancer cells

Liu G, Yin Q, Ji H, Wang Y, Liu H, Jiang L, Zhu F, Li B

Drug Design, Development and Therapy 2018, 12:3899-3912

Published Date: 13 November 2018

CTL019 (tisagenlecleucel): CAR-T therapy for relapsed and refractory B-cell acute lymphoblastic leukemia

Vairy S, Lopes Garcia J, Teira P, Bittencourt H

Drug Design, Development and Therapy 2018, 12:3885-3898

Published Date: 12 November 2018

Risankizumab: an anti-IL-23 antibody for the treatment of psoriasis

Haugh IM, Preston AK, Kivelevitch DN, Menter AM

Drug Design, Development and Therapy 2018, 12:3879-3883

Published Date: 12 November 2018

The therapeutic effects of traditional Chinese medicine Fusu agent in LPS-induced acute lung injury model rats

Gao P, Zhao Z, Zhang C, Wang C, Long K, Guo L, Li B

Drug Design, Development and Therapy 2018, 12:3867-3878

Published Date: 13 November 2018

The effects of macrolides in children with reactive airway disease: a systematic review and meta-analysis of randomized controlled trials

Lei WT, Lin HH, Tsai MC, Hung HH, Cheng YJ, Liu SJ, Lin CY, Yeh TL

Drug Design, Development and Therapy 2018, 12:3825-3845

Published Date: 8 November 2018

An insight into new strategies to combat antifungal drug resistance

Zheng YH, Ma YY, Ding Y, Chen XQ, Gao GX

Drug Design, Development and Therapy 2018, 12:3807-3816

Published Date: 5 November 2018

The effect of food and liquid pH on the integrity of enteric-coated beads from cysteamine bitartrate delayed-release capsules [Corrigendum]

Pavloff N, Hauser TA, Williams C, Isbell SL, Cadieux B, Johnson M

Drug Design, Development and Therapy 2018, 12:3797-3798

Published Date: 5 November 2018

Histopathological study of liver tissue due to methadone consumption and its effect on liver enzymes and inflammatory indices in rat

Amraei M, Mohamadpour M, Hafezi Ahmadi MR, Azizi M, Daemi A, Omidi M, Shirzadpour E

Drug Design, Development and Therapy 2018, 12:3785-3795

Published Date: 5 November 2018

Concomitant food intake does not affect the efficacy of entecavir in chronic hepatitis B patients with virological response: a randomized, multicenter, noninferiority trial

Cho EJ, Yu SJ, Kwon SY, Kim JH, Kim DY, Kim W, Lee JS, Lee JW, Lee YJ, Chae HB, Yoon JH

Drug Design, Development and Therapy 2018, 12:3767-3774

Published Date: 2 November 2018

Identification of new inhibitors of Mdm2–p53 interaction via pharmacophore and structure-based virtual screening

Atatreh N, Ghattas MA, Bardaweel SK, Al Rawashdeh S, Al Sorkhy M

Drug Design, Development and Therapy 2018, 12:3741-3752

Published Date: 2 November 2018

Two-drug regimens for treatment of naïve HIV-1 infection and as maintenance therapy

Corado KC, Caplan MR, Daar ES

Drug Design, Development and Therapy 2018, 12:3731-3740

Published Date: 1 November 2018

Efficacy evaluation of reteplase in a novel canine acute pulmonary thromboembolism model developed by minimally invasive surgery and digital subtraction angiography

Zhang Y, Liu H, Zhang Y, Wu Q, Zhang Y, Zhang J, Zhou X, Jiao H, Fan F, Xue Q, Wang X, Zhong Z

Drug Design, Development and Therapy 2018, 12:3717-3730

Published Date: 1 November 2018

Saponins enhance exon skipping of 2′-O-methyl phosphorothioate oligonucleotide in vitro and in vivo

Wang M, Wu B, Shah SN, Lu P, Lu Q

Drug Design, Development and Therapy 2018, 12:3705-3715

Published Date: 31 October 2018

Meta-analysis of rosuvastatin efficacy in prevention of contrast-induced acute kidney injury

Zhang J, Guo Y, Jin Q, Bian L, Lin P

Drug Design, Development and Therapy 2018, 12:3685-3690

Published Date: 31 October 2018

Formononetin induces vasorelaxation in rat thoracic aorta via regulation of the PI3K/PTEN/Akt signaling pathway

Li T, Zhong Y, Tang T, Luo J, Cui H, Fan R, Wang Y, Wang D

Drug Design, Development and Therapy 2018, 12:3675-3684

Published Date: 1 November 2018

Efficacy and safety of Tongfu powder in acute pancreatitis patients with gastrointestinal dysfunction: a clinical trial

Miao B, Li FW, Zhang SW, Wang H, Qi WJ, Wang C

Drug Design, Development and Therapy 2018, 12:3665-3673

Published Date: 31 October 2018

Pharmacokinetic evaluation of a transdermal anastrozole-in-adhesive formulation

Regenthal R, Voskanian M, Baumann F, Teichert J, Brätter C, Aigner A, Abraham G

Drug Design, Development and Therapy 2018, 12:3653-3664

Published Date: 1 November 2018

Transfer of rosuvastatin into breast milk: liquid chromatography–mass spectrometry methodology and clinical recommendations

Lwin EMP, Leggett C, Ritchie U, Gerber C, Song Y, Hague W, Turner S, Upton R, Garg S

Drug Design, Development and Therapy 2018, 12:3645-3651

Published Date: 29 October 2018

Pharmacokinetic and bioequivalence study comparing a fimasartan/rosuvastatin fixed-dose combination with the concomitant administration of fimasartan and rosuvastatin in healthy subjects

Kang WY, Seong SJ, Ohk B, Gwon MR, Kim BK, Cho S, Shim WS, Lee KT, Kim EH, Yang DH, Lee HW, Yoon YR

Drug Design, Development and Therapy 2018, 12:3607-3615

Published Date: 26 October 2018

Asiatic acid protests against myocardial ischemia/reperfusion injury via modulation of glycometabolism in rat cardiomyocyte

Dai Y, Wang Z, Quan M, Lv Y, Li Y, Xin HB, Qian Y

Drug Design, Development and Therapy 2018, 12:3573-3582

Published Date: 25 October 2018

Lobaplatin inhibits breast cancer progression, cell proliferation while it induces cell apoptosis by downregulating MTDH expression

Tian W, Hao S, Gao B, Jiang Y, Zhang X, Zhang S, Guo L, Zhao J, Zhang G, Chen Y, Li Z, Luo D

Drug Design, Development and Therapy 2018, 12:3563-3571

Published Date: 29 October 2018

Entrectinib and other ALK/TRK inhibitors for the treatment of neuroblastoma

Pacenta HL, Macy ME

Drug Design, Development and Therapy 2018, 12:3549-3561

Published Date: 23 October 2018

Glutathione S-transferase π: a potential role in antitumor therapy

Dong S, Sha H, Xu X, Hu T, Lou R, Li H, Wu J, Dan C, Feng J

Drug Design, Development and Therapy 2018, 12:3535-3547

Published Date: 23 October 2018

Antioxidative stress effects of vitamins C, E, and B12, and their combination can protect the liver against acetaminophen-induced hepatotoxicity in rats

Abdulkhaleq FM, Alhussainy TM, Badr MM, Abu Khalil AA, Gammoh O, Ghanim BY, Qinna NA

Drug Design, Development and Therapy 2018, 12:3525-3533

Published Date: 18 October 2018

Intranasal niosomes of nefopam with improved bioavailability: preparation, optimization, and in-vivo evaluation

Abou-Taleb HA, Khallaf RA, Abdel-Aleem JA

Drug Design, Development and Therapy 2018, 12:3501-3516

Published Date: 17 October 2018

The retinoprotective role of phenytoin

Bartollino S, Chiosi F, di Staso S, Uva M, Pascotto A, Rinaldi M, Keppel Hesselink JM, Costagliola C

Drug Design, Development and Therapy 2018, 12:3485-3489

Published Date: 16 October 2018

The efficacy and safety of aflibercept and conbercept in diabetic macular edema

Cai S, Yang Q, Li X, Zhang Y

Drug Design, Development and Therapy 2018, 12:3471-3483

Published Date: 15 October 2018

Inhibition of sialidase activity as a therapeutic approach

Glanz VY, Myasoedova VA, Grechko AV, Orekhov AN

Drug Design, Development and Therapy 2018, 12:3431-3437

Published Date: 10 October 2018

All-trans retinoic acid can antagonize osteoblastogenesis induced by different BMPs irrespective of their dimerization types and dose-efficiencies

Liu Y, Ma X, Guo J, Lin Z, Zhou M, Bi W, Liu J, Wang J, Lu H, Wu G

Drug Design, Development and Therapy 2018, 12:3419-3430

Published Date: 10 October 2018

Synthesis and anticancer activity of dimeric podophyllotoxin derivatives

Zi C, Yang L, Xu F, Dong F, Yang D, Li Y, Ding Z, Zhou J, Jiang Z, Hu J

Drug Design, Development and Therapy 2018, 12:3393-3406

Published Date: 9 October 2018

Immediate release tablet formulation of varenicline salicylate and comparative pharmacokinetic study in human volunteers

Kwak SS, Lee ES, Yoon HY, Kim CH, Goo YT, Kang MJ, Lee S, Lee BS, Jeon HR, Oh CH, Choi YW

Drug Design, Development and Therapy 2018, 12:3377-3392

Published Date: 9 October 2018

Utility of nintedanib for severe idiopathic pulmonary fibrosis: a single-center retrospective study

Abe M, Tsushima K, Sakayori M, Suzuki K, Ikari J, Terada J, Tatsumi K

Drug Design, Development and Therapy 2018, 12:3369-3375

Published Date: 9 October 2018

Therapeutic effects of tyroserleutide on lung metastasis of human hepatocellular carcinoma SK-HEP-1 and its mechanism affecting ICAM-1 and MMP-2 and -9

Che X, Lu R, Fu Z, Sun Y, Zhu Z, Li J, Wang S, Jia J, Wang Q, Yao Z

Drug Design, Development and Therapy 2018, 12:3357-3368

Published Date: 9 October 2018

Indirubin suppresses ovarian cancer cell viabilities through the STAT3 signaling pathway

Chen L, Wang J, Wu J, Zheng Q, Hu J

Drug Design, Development and Therapy 2018, 12:3335-3342

Published Date: 4 October 2018

Evaluation of methotrexate-conjugated gadolinium(III) for cancer diagnosis and treatment

Xu D, Lu ST, Li YS, Baidya A, Mei H, He Y, Wu B

Drug Design, Development and Therapy 2018, 12:3301-3309

Published Date: 5 October 2018

Effect of butorphanol on opioid-induced cough: a meta-analysis of randomized controlled trials

Zhang J, Miao S, Tu Q, Shi M, Zou L, Liu S, Wang G

Drug Design, Development and Therapy 2018, 12:3263-3268

Published Date: 2 October 2018

Baicalin suppresses proliferation, migration, and invasion in human glioblastoma cells via Ca2+-dependent pathway

Zhu Y, Fang J, Wang H, Fei M, Tang T, Liu K, Niu W, Zhou Y

Drug Design, Development and Therapy 2018, 12:3247-3261

Published Date: 2 October 2018

Copper-64: a real theranostic agent

Gutfilen B, Souza SAL, Valentini G

Drug Design, Development and Therapy 2018, 12:3235-3245

Published Date: 2 October 2018

Lactobacilli with superoxide dismutase-like or catalase activity are more effective in alleviating inflammation in an inflammatory bowel disease mouse model

Tomusiak-Plebanek A, Heczko P, Skowron B, Baranowska A, Okoń K, Thor PJ, Strus M

Drug Design, Development and Therapy 2018, 12:3221-3233

Published Date: 28 September 2018

Synergistic combination therapy of lung cancer using paclitaxel- and triptolide-coloaded lipid–polymer hybrid nanoparticles

Liu J, Cheng H, Han L, Qiang Z, Zhang X, Gao W, Zhao K, Song Y

Drug Design, Development and Therapy 2018, 12:3199-3209

Published Date: 25 September 2018

Colorectal cancer combination therapy using drug and gene co-delivered, targeted poly(ethylene glycol)-ε-poly(caprolactone) nanocarriers

Wang Z, Wei Y, Fang G, Hong D, An L, Jiao T, Shi Y, Zang A

Drug Design, Development and Therapy 2018, 12:3171-3180

Published Date: 24 September 2018

Intravenous tranexamic acid use in revision total joint arthroplasty: a meta-analysis

Kuo FC, Lin PY, Wang JW, Lin PC, Lee MS, Chen AF

Drug Design, Development and Therapy 2018, 12:3163-3170

Published Date: 24 September 2018

Current development of biodegradable polymeric materials for biomedical applications

Song R, Murphy M, Li C, Ting K, Soo C, Zheng Z

Drug Design, Development and Therapy 2018, 12:3117-3145

Published Date: 24 September 2018

A targeted therapy for melanoma by graphene oxide composite with microRNA carrier

Liu C, Xie H, Yu JG, Chen X, Tang S, Sun L, Chen X, Peng D, Zhang X, Zhou J

Drug Design, Development and Therapy 2018, 12:3095-3106

Published Date: 21 September 2018

Comparison of the efficacy and survival analysis of neoadjuvant chemotherapy for Her-2-positive breast cancer

Li S, Wei W, Jiang Y, Li Q, Huang Q, Yang H, Liu J

Drug Design, Development and Therapy 2018, 12:3085-3093

Published Date: 21 September 2018

Effects of hydroxyethyl starch 130/0.4 on the kidney tissue of rats with ureteral obstruction

Güneş I, Süngü N, Kılıçarslan A, Şıvgın V, Alkan M, Küçük A, Boyunağa H, Ünal Y, Arslan M

Drug Design, Development and Therapy 2018, 12:3061-3070

Published Date: 20 September 2018

Chemotherapeutic drug targeting to lungs by way of microspheres after intravenous administration

Sangi S, SreeHarsha N, Bawadekji A, Al Ali M

Drug Design, Development and Therapy 2018, 12:3051-3060

Published Date: 18 September 2018

Sintered dicalcium pyrophosphate treatment attenuates estrogen deficiency-associated disc degeneration in ovariectomized rats

Chen CH, Chen WC, Lin CY, Chen CH, Tsuang YH, Kuo YJ

Drug Design, Development and Therapy 2018, 12:3033-3041

Published Date: 18 September 2018

Zoledronate inhibits fibroblasts’ proliferation and activation via targeting TGF-β signaling pathway

Zhao Z, Shen W, Zhu H, Lin L, Jiang G, Zhu Y, Song H, Wu L

Drug Design, Development and Therapy 2018, 12:3021-3031

Published Date: 17 September 2018

Novel anti-inflammatory film as a delivery system for the external medication with bioactive phytochemical “Apocynin”

Anter HM, Abu Hashim II, Awadin W, Meshali MM

Drug Design, Development and Therapy 2018, 12:2981-3001

Published Date: 13 September 2018

Astragaloside IV represses high glucose-induced mesangial cells activation by enhancing autophagy via SIRT1 deacetylation of NF-κB P65 subunit

Wang X, Gao Y, Tian N, Zhu Z, Wang T, Xu J, Wu B, Zhang N

Drug Design, Development and Therapy 2018, 12:2971-2980

Published Date: 12 September 2018

Saikosaponin A modulates remodeling of Kv4.2-mediated A-type voltage-gated potassium currents in rat chronic temporal lobe epilepsy

Hong Y, Deng N, Jin H, Xuan Z, Qian YX, Wu ZY, Xie W

Drug Design, Development and Therapy 2018, 12:2945-2958

Published Date: 11 September 2018

GlycoPEGylated recombinant factor IX for hemophilia B in context

Santagostino E, Mancuso ME

Drug Design, Development and Therapy 2018, 12:2933-2943

Published Date: 11 September 2018

Papaverine hydrochloride containing nanostructured lyotropic liquid crystal formulation as a potential drug delivery system for the treatment of erectile dysfunction

Berkó S, Zsikó S, Deák G, Gácsi A, Kovács A, Budai-Szűcs M, Pajor L, Bajory Z, Csányi E

Drug Design, Development and Therapy 2018, 12:2923-2931

Published Date: 12 September 2018

In vitro and in vivo evaluation of cephalosporins for the treatment of Lyme disease

Pothineni VR, Parekh MB, Babar MM, Ambati A, Maguire P, Inayathullah M, Kim K, Tayebi L, Potula HS, Rajadas J

Drug Design, Development and Therapy 2018, 12:2915-2921

Published Date: 11 September 2018

Chemopreventive activity of sulforaphane

Jiang X, Liu Y, Ma L, Ji R, Qu Y, Xin Y, Lv G

Drug Design, Development and Therapy 2018, 12:2905-2913

Published Date: 11 September 2018

Inhibitor of IGF1 receptor alleviates the inflammation process in the diabetic kidney mouse model without activating SOCS2

Li J, Dong R, Yu J, Yi S, Da J, Yu F, Zha Y

Drug Design, Development and Therapy 2018, 12:2887-2896

Published Date: 11 September 2018

Eremomycin pyrrolidide: a novel semisynthetic glycopeptide with improved chemotherapeutic properties

Olsufyeva EN, Shchekotikhin AE, Bychkova EN, Pereverzeva ER, Treshalin ID, Mirchink EP, Isakova EB, Chernobrovkin MG, Kozlov RS, Dekhnich AV, Preobrazhenskaya MN

Drug Design, Development and Therapy 2018, 12:2875-2885

Published Date: 10 September 2018

Profile of atezolizumab in the treatment of metastatic non-small-cell lung cancer: patient selection and perspectives

Facchinetti F, Bordi P, Leonetti A, Buti S, Tiseo M

Drug Design, Development and Therapy 2018, 12:2857-2873

Published Date: 10 September 2018

Macrocyclic lactones inhibit nasopharyngeal carcinoma cells proliferation through PAK1 inhibition and reduce in vivo tumor growth

Gallardo F, Mariamé B, Gence R, Tilkin-Mariamé AF

Drug Design, Development and Therapy 2018, 12:2805-2814

Published Date: 7 September 2018

The effect of food and liquid pH on the integrity of enteric-coated beads from cysteamine bitartrate delayed-release capsules

Pavloff N, Hauser TA, Williams C, Isbell SL, Cadieux B, Johnson M

Drug Design, Development and Therapy 2018, 12:2795-2804

Published Date: 6 September 2018

Efficacy and safety of a fixed-dose combination of nimesulide/pantoprazole compared to naproxen/esomeprazole for pain relief in patients with osteoarticular diseases and dyspeptic symptoms

Scheinberg M, Pott Júnior H, Macêdo EA, Bocchi de Oliveira MF, Ecclissato C, Amazonas RB

Drug Design, Development and Therapy 2018, 12:2775-2783

Published Date: 6 September 2018

Are laboratory parameter (biomarker) values similar to the healthy volunteer reference range in all patient populations?

Brott DA, Goodman MJ, Hermann RP, Merz M, Calvo R, Poorkhalkali N, Kiazand A

Drug Design, Development and Therapy 2018, 12:2757-2773

Published Date: 6 September 2018

Safety and efficacy of elbasvir/grazoprevir for the treatment of chronic hepatitis C: current evidence

Morikawa K, Nakamura A, Shimazaki T, Sakamoto N

Drug Design, Development and Therapy 2018, 12:2749-2756

Published Date: 5 September 2018

17β-estradiol ameliorates oxidative stress and blue light-emitting diode-induced retinal degeneration by decreasing apoptosis and enhancing autophagy

Wei Q, Liang X, Peng Y, Yu D, Zhang R, Jin H, Fan J, Cai W, Ren C, Yu J

Drug Design, Development and Therapy 2018, 12:2715-2730

Published Date: 4 September 2018

Fasudil inhibits actin polymerization and collagen synthesis and induces apoptosis in human urethral scar fibroblasts via the Rho/ROCK pathway

Li XD, Wu YP, Chen SH, Liang YC, Lin TT, Lin T, Wei Y, Xue XY, Zheng QS, Xu N

Drug Design, Development and Therapy 2018, 12:2707-2713

Published Date: 3 September 2018

The total alkaloids from Coptis chinensis Franch improve cognitive deficits in type 2 diabetic rats

Li JC, Shen XF, Shao JA, Tao MM, Gu J, Li J, Huang N

Drug Design, Development and Therapy 2018, 12:2695-2706

Published Date: 31 August 2018

Asenapine pharmacokinetics and tolerability in a pediatric population

Dogterom P, Riesenberg R, de Greef R, Dennie J, Johnson M, Pilla Reddy V, Miltenburg AMM, Findling RL, Jakate A, Carrothers TJ, Troyer MD

Drug Design, Development and Therapy 2018, 12:2677-2693

Published Date: 30 August 2018

Profile of pitolisant in the management of narcolepsy: design, development, and place in therapy

Romigi A, Vitrani G, Lo Giudice T, Centonze D, Franco V

Drug Design, Development and Therapy 2018, 12:2665-2675

Published Date: 30 August 2018

Inhibiting eEF-2 kinase-mediated autophagy enhanced the cytocidal effect of AKT inhibitor on human nasopharyngeal carcinoma

Zhao YY, Tian Y, Liu L, Zhan JH, Hou X, Chen X, Zhou T, Huang Y, Zhang L

Drug Design, Development and Therapy 2018, 12:2655-2663

Published Date: 29 August 2018

A novel multifunctional anti-CEA-IL15 molecule displays potent antitumor activities

Liu Y, Wang Y, Xing J, Li Y, Liu J, Wang Z

Drug Design, Development and Therapy 2018, 12:2645-2654

Published Date: 29 August 2018

Spectroscopic and molecular modeling studies of binding interaction between bovine serum albumin and roflumilast

Wani TA, Bakheit AH, Ansari MN, Al-Majed ARA, Al-Qahtani BM, Zargar S

Drug Design, Development and Therapy 2018, 12:2627-2634

Published Date: 28 August 2018

Fabrication and characterization of dexibuprofen nanocrystals using microchannel fluidic rector

Khan J, Bashir S, Khan MA, Mohammad MA, Isreb M

Drug Design, Development and Therapy 2018, 12:2617-2626

Published Date: 29 August 2018

Genetically engineered drug rhCNB induces apoptosis and cell cycle arrest in both gastric cancer cells and hepatoma cells

Guo Y, Huang Y, Tian S, Xie X, Xing G, Fu J

Drug Design, Development and Therapy 2018, 12:2567-2575

Published Date: 20 August 2018

MEK inhibitors for the treatment of NRAS mutant melanoma

Sarkisian S, Davar D

Drug Design, Development and Therapy 2018, 12:2553-2565

Published Date: 20 August 2018

Development of prednisolone-containing eye drop formulations by cyclodextrin complexation and antimicrobial, mucoadhesive biopolymer

Bíró T, Horvát G, Budai-Szűcs M, Csányi E, Urbán E, Facskó A, Szabó-Révész P, Csóka I, Aigner Z

Drug Design, Development and Therapy 2018, 12:2529-2537

Published Date: 15 August 2018

Current research for a vaccine against Lassa hemorrhagic fever virus

Warner BM, Safronetz D, Stein DR

Drug Design, Development and Therapy 2018, 12:2519-2527

Published Date: 14 August 2018

Baicalin provides neuroprotection in traumatic brain injury mice model through Akt/Nrf2 pathway

Fang J, Wang H, Zhou J, Dai W, Zhu Y, Zhou Y, Wang X, Zhou M

Drug Design, Development and Therapy 2018, 12:2497-2508

Published Date: 10 August 2018

Milnacipran poorly modulates pain in patients suffering from fibromyalgia: a randomized double-blind controlled study

Pickering G, Macian N, Delage N, Picard P, Cardot JM, Sickout-Arondo S, Giron F, Dualé C, Pereira B, Marcaillou F

Drug Design, Development and Therapy 2018, 12:2485-2496

Published Date: 10 August 2018

Preclinical safety evaluation of hepatic arterial infusion of oncolytic poxvirus

Cho E, Ryu EJ, Jiang F, Jeon UB, Cho M, Kim CH, Kim M, Kim ND, Hwang TH

Drug Design, Development and Therapy 2018, 12:2467-2474

Published Date: 8 August 2018

Systematic review and meta-analysis of the benefit of celecoxib in treating advanced non-small-cell lung cancer

Yi L, Zhang W, Zhang H, Shen J, Zou J, Luo P, Zhang J

Drug Design, Development and Therapy 2018, 12:2455-2466

Published Date: 7 August 2018

Antihyperlipidemic studies of newly synthesized phenolic derivatives: in silico and in vivo approaches

Aqeel MT, ur-Rahman N, Khan A, Ashraf Z, Latif M, Rafique H, Rasheed U

Drug Design, Development and Therapy 2018, 12:2443-2453

Published Date: 9 August 2018

Monitoring antiangiogenesis of bevacizumab in zebrafish

Zhang J, Gao BL, Zhang WC, Qian ZJ, Xiang Y

Drug Design, Development and Therapy 2018, 12:2423-2430

Published Date: 6 August 2018

Sinomenine inhibits the growth of melanoma by enhancement of autophagy via PI3K/AKT/mTOR inhibition

Sun Z, Zheng L, Liu X, Xing W, Liu X

Drug Design, Development and Therapy 2018, 12:2413-2421

Published Date: 6 August 2018

Zafirlukast in combination with pseudohypericin attenuates spinal cord injury and motor function in experimental mice

Chen XG, Hua F, Wang SG, Xu YY, Yue HT, Sun J

Drug Design, Development and Therapy 2018, 12:2389-2402

Published Date: 1 August 2018

Comparison of biosimilar filgrastim with a reference product: pharmacokinetics, pharmacodynamics, and safety profiles in healthy volunteers

Choi C, Yoo BW, Kim CO, Hong T, Jin BH, Seo KS, Jang JY, Park MS

Drug Design, Development and Therapy 2018, 12:2381-2387

Published Date: 1 August 2018

Pharmacological mechanism of roflumilast in the treatment of asthma–COPD overlap

Zhang X, Chen Y, Fan L, Ye J, Fan J, Xu X, You D, Liu S, Chen X, Luo P

Drug Design, Development and Therapy 2018, 12:2371-2379

Published Date: 1 August 2018

Doxorubicin-conjugated dexamethasone induced MCF-7 apoptosis without entering the nucleus and able to overcome MDR-1-induced resistance

Chaikomon K, Chattong S, Chaiya T, Tiwawech D, Sritana-Anant Y, Sereemaspun A, Manotham K

Drug Design, Development and Therapy 2018, 12:2361-2369

Published Date: 1 August 2018

Discovery of nonnucleoside inhibitors of polymerase from infectious pancreatic necrosis virus (IPNV)

Bello-Pérez M, Falco A, Galiano V, Coll J, Perez L, Encinar JA

Drug Design, Development and Therapy 2018, 12:2337-2359

Published Date: 30 July 2018

Role of janus kinase inhibitors in the treatment of alopecia areata

Triyangkulsri K, Suchonwanit P

Drug Design, Development and Therapy 2018, 12:2323-2335

Published Date: 27 July 2018

Care pathways and treatment patterns for patients with heart failure in China: results from a cross-sectional survey

Jackson JDS, Cotton SE, Bruce Wirta S, Proenca CC, Zhang M, Lahoz R, Balas B, Calado FJ

Drug Design, Development and Therapy 2018, 12:2311-2321

Published Date: 26 July 2018

Pharmacokinetic interaction between fimasartan and atorvastatin in healthy male volunteers

Choi Y, Lee S, Jang IJ, Yu KS

Drug Design, Development and Therapy 2018, 12:2301-2309

Published Date: 24 July 2018

Effects of the traditional Chinese medicine baicalein on the viability of random pattern skin flaps in rats

Lin R, Lin J, Li S, Ding J, Wu H, Xiang G, Li S, Huang Y, Lin D, Gao W, Kong J, Xu H, Zhou K

Drug Design, Development and Therapy 2018, 12:2267-2276

Published Date: 23 July 2018

The effects of bisphosphonates on osteoporotic patients after lumbar fusion: a meta-analysis

Liu WB, Zhao WT, Shen P, Zhang FJ

Drug Design, Development and Therapy 2018, 12:2233-2240

Published Date: 17 July 2018

Radiosensitivity enhancement by combined treatment of nimotuzumab and celecoxib on nasopharyngeal carcinoma cells

Huang JF, Yuan XP, Pang QF, Zhang HW, Yu JH, Yang B, Zhou LY, Zhang FZ, Liu FJ

Drug Design, Development and Therapy 2018, 12:2223-2231

Published Date: 16 July 2018

Emodin mitigates podocytes apoptosis induced by endoplasmic reticulum stress through the inhibition of the PERK pathway in diabetic nephropathy

Tian N, Gao Y, Wang X, Wu X, Zou D, Zhu Z, Han ZJ, Wang T, Shi Y

Drug Design, Development and Therapy 2018, 12:2195-2211

Published Date: 13 July 2018

Antifungal activity of Cardiospermum halicacabum L. (Sapindaceae) against Trichophyton rubrum occurs through molecular interaction with fungal Hsp90

Gaziano R, Campione E, Iacovelli F, Marino D, Pica F, Di Francesco P, Aquaro S, Menichini F, Falconi M, Bianchi L

Drug Design, Development and Therapy 2018, 12:2185-2193

Published Date: 12 July 2018

A case report of toxic epidermal necrolysis associated with AZD-9291

Wang J, Cheng XY, Lu Y, Zhou BR

Drug Design, Development and Therapy 2018, 12:2163-2167

Published Date: 11 July 2018

Effect of green tea catechins on the pharmacokinetics of digoxin in humans

Kim TE, Shin KH, Park JE, Kim MG, Yun YM, Choi DH, Kwon KJ, Lee J

Drug Design, Development and Therapy 2018, 12:2139-2147

Published Date: 10 July 2018

Development of a tin oxide carrier with mesoporous structure for improving the dissolution rate and oral relative bioavailability of fenofibrate

Bai A, Wu C, Liu X, Lv H, Xu X, Cao Y, Shang W, Hu L, Liu Y

Drug Design, Development and Therapy 2018, 12:2129-2138

Published Date: 10 July 2018

Self-nanomicellizing solid dispersion of edaravone: part II: in vivo assessment of efficacy against behavior deficits and safety in Alzheimer’s disease model

Parikh A, Kathawala K, Li JT, Chen C, Shan Z, Cao X, Wang YJ, Garg S, Zhou XF

Drug Design, Development and Therapy 2018, 12:2111-2128

Published Date: 9 July 2018

Design and development of ICCA as a dual inhibitor of GPIIb/IIIa and P-selectin receptors

Chen H, Lu A, Zhang X, Gui L, Wang YN, Wu J, Feng H, Peng S, Zhao M

Drug Design, Development and Therapy 2018, 12:2097-2110

Published Date: 9 July 2018

Safety and efficacy of durvalumab (MEDI4736) in various solid tumors

Yang H, Shen K, Zhu C, Li Q, Zhao Y, Ma X

Drug Design, Development and Therapy 2018, 12:2085-2096

Published Date: 6 July 2018

Self-nanomicellizing solid dispersion of edaravone: part I – oral bioavailability improvement

Parikh A, Kathawala K, Tan CC, Garg S, Zhou XF

Drug Design, Development and Therapy 2018, 12:2051-2069

Published Date: 5 July 2018

Antiangiogenic cytokines as potential new therapeutic targets for resveratrol in diabetic retinopathy

Popescu M, Bogdan C, Pintea A, Rugină D, Ionescu C

Drug Design, Development and Therapy 2018, 12:1985-1996

Published Date: 3 July 2018

Pharmacokinetics of placental protein 13 after intravenous and subcutaneous administration in rabbits

Drobnjak T, Meiri H, Mandalà M, Huppertz B, Gizurarson S

Drug Design, Development and Therapy 2018, 12:1977-1983

Published Date: 3 July 2018

Gemcitabine hydrochloride microspheres used for intravesical treatment of superficial bladder cancer: a comprehensive in vitro/ex vivo/in vivo evaluation

Karavana SY, Ay Şenyiğit Z, Çalışkan Ç, Sevin G, İlem Özdemir D, Erzurumlu Y, Şen S, Baloğlu E

Drug Design, Development and Therapy 2018, 12:1959-1975

Published Date: 2 July 2018

Daptomycin: a comparison of two intravenous formulations

Frankenfeld C, Mittal S, Melendez Y, Mendez-Vigo L, Lamp KC, Keller KN, Bertolami SR

Drug Design, Development and Therapy 2018, 12:1953-1958

Published Date: 29 June 2018

Mechanism of Yanghe Pingchuan granules treatment for airway remodeling in asthma

Pan LY, Han YQ, Wang YZ, Chen QQ, Wu Y, Sun Y

Drug Design, Development and Therapy 2018, 12:1941-1951

Published Date: 27 June 2018

Electroporation-enhanced transdermal diclofenac sodium delivery into the knee joint in a rat model of acute arthritis

Hartmann P, Butt E, Fehér Á, Szilágyi ÁL, Jász KD, Balázs B, Bakonyi M, Berkó S, Erős G, Boros M, Horváth G, Varga E, Csányi E

Drug Design, Development and Therapy 2018, 12:1917-1930

Published Date: 27 June 2018

The mechanism of botulinum A on Raynaud syndrome

Zhou Y, Liu Y, Hao Y, Feng Y, Pan L, Liu W, Li B, Xiao L, Jin L, Nie Z

Drug Design, Development and Therapy 2018, 12:1905-1915

Published Date: 26 June 2018

Modes of cell death induced by tetrahydroisoquinoline-based analogs in MDA-MB-231 breast and A549 lung cancer cell lines

Nel M, Joubert AM, Dohle W, Potter BVL, Theron AE

Drug Design, Development and Therapy 2018, 12:1881-1904

Published Date: 25 June 2018

Additive effect of oral LDD175 to tamsulosin and finasteride in a benign prostate hyperplasia rat model

Choi BR, Kim HK, Soni KK, Karna KK, Lee SW, So I, Park JK

Drug Design, Development and Therapy 2018, 12:1855-1863

Published Date: 22 June 2018

Salidroside ameliorates autophagy and activation of hepatic stellate cells in mice via NF-κB and TGF-β1/Smad3 pathways

Feng J, Chen K, Xia Y, Wu L, Li J, Li S, Wang W, Lu X, Liu T, Guo C

Drug Design, Development and Therapy 2018, 12:1837-1853

Published Date: 22 June 2018

Sevoflurane anaesthesia during pregnancy in mice induces hearing impairment in the offspring

Shen X, Xiao Y, Li W, Chen K, Yu H

Drug Design, Development and Therapy 2018, 12:1827-1836

Published Date: 22 June 2018

Use of levosimendan in the treatment of cerebral vascular vasospasm: a case study

Onichimowski D, Nosek K, Goraj R, Jalali R, Wińska A, Pawlos A, Tuyakov B

Drug Design, Development and Therapy 2018, 12:1777-1783

Published Date: 20 June 2018

Clinical efficacy of nab-paclitaxel in patients with metastatic pancreatic cancer

De Luca R, Blasi L, Alù M, Gristina V, Cicero G

Drug Design, Development and Therapy 2018, 12:1769-1775

Published Date: 19 June 2018

Linezolid: a review of its properties, function, and use in critical care

Hashemian SMR, Farhadi T, Ganjparvar M

Drug Design, Development and Therapy 2018, 12:1759-1767

Published Date: 18 June 2018

Lights and shadows of NSAIDs in bone healing: the role of prostaglandins in bone metabolism

Lisowska B, Kosson D, Domaracka K

Drug Design, Development and Therapy 2018, 12:1753-1758

Published Date: 18 June 2018

Annatto-derived tocotrienol stimulates osteogenic activity in preosteoblastic MC3T3-E1 cells: a temporal sequential study

Wan Hasan WN, Abd Ghafar N, Chin KY, Ima-Nirwana S

Drug Design, Development and Therapy 2018, 12:1715-1726

Published Date: 13 June 2018

Effect of food on the pharmacokinetic characteristics of a single oral dose of LCB01-0371, a novel oxazolidinone antibiotic

Sunwoo J, Kim YK, Choi Y, Yu KS, Nam H, Cho YL, Yoon S, Chung JY

Drug Design, Development and Therapy 2018, 12:1707-1714

Published Date: 11 June 2018

Chloroquine and hydroxychloroquine are associated with reduced cardiovascular risk: a systematic review and meta-analysis

Liu D, Li X, Zhang Y, Kwong JSW, Li L, Zhang Y, Xu C, Li Q, Sun X, Tian H, Li S

Drug Design, Development and Therapy 2018, 12:1685-1695

Published Date: 11 June 2018

Burden of heart failure on caregivers in China: results from a cross-sectional survey

Jackson JDS, Cotton SE, Bruce Wirta S, Proenca CC, Zhang M, Lahoz R, Calado FJ

Drug Design, Development and Therapy 2018, 12:1669-1678

Published Date: 8 June 2018

Burden of heart failure on patients from China: results from a cross-sectional survey

Jackson JDS, Cotton SE, Bruce Wirta S, Proenca CC, Zhang M, Lahoz R, Calado FJ

Drug Design, Development and Therapy 2018, 12:1659-1668

Published Date: 8 June 2018

AMPK/AS160 mediates tiliroside derivatives-stimulated GLUT4 translocation in muscle cells

Zhang C, Jiang Y, Liu J, Jin M, Qin N, Chen Y, Niu W, Duan H

Drug Design, Development and Therapy 2018, 12:1581-1587

Published Date: 1 June 2018

Optimization of a combined wet milling process in order to produce poly(vinyl alcohol) stabilized nanosuspension

Bartos C, Jójárt-Laczkovich O, Katona G, Budai-Szűcs M, Ambrus R, Bocsik A, Gróf I, Deli MA, Szabó-Révész P

Drug Design, Development and Therapy 2018, 12:1567-1580

Published Date: 31 May 2018

2-Amino-1,3,4-thiadiazole as a potential scaffold for promising antimicrobial agents

Serban G, Stanasel O, Serban E, Bota S

Drug Design, Development and Therapy 2018, 12:1545-1566

Published Date: 31 May 2018

Formulation and in vitro characterization of rifampicin-loaded porous poly (ε-caprolactone) microspheres for sustained skeletal delivery

Mei Q, Luo P, Zuo Y, Li J, Zou Q, Li Y, Jiang D, Wang Y

Drug Design, Development and Therapy 2018, 12:1533-1544

Published Date: 31 May 2018

Incidence and risk of cardiac toxicities in patients with relapsed and refractory multiple myeloma treated with carfilzomib

Zhao F, Yang B, Wang J, Zhang R, Liu J, Yin F, Xu W, He C

Drug Design, Development and Therapy 2018, 12:1525-1531

Published Date: 30 May 2018

Spotlight on olaparib in the treatment of BRCA-mutated ovarian cancer: design, development and place in therapy

Lorusso D, Tripodi E, Maltese G, Lepori S, Sabatucci I, Bogani G, Raspagliesi F

Drug Design, Development and Therapy 2018, 12:1501-1509

Published Date: 29 May 2018

Pharmacological activities, mechanisms of action, and safety of salidroside in the central nervous system

Zhong ZF, Han J, Zhang JZ, Xiao Q, Hu J, Chen LD

Drug Design, Development and Therapy 2018, 12:1479-1489

Published Date: 24 May 2018

Synthesis and evaluation of ortho-[18F]fluorocelecoxib for COX-2 cholangiocarcinoma imaging

Chang CW, Yeh CN, Chung YH, Chen YR, Tien SW, Chen TW, Farn SS, Huang YC, Yu CS

Drug Design, Development and Therapy 2018, 12:1467-1478

Published Date: 24 May 2018

nab-Paclitaxel/carboplatin in elderly patients with advanced squamous non-small cell lung cancer: a retrospective analysis of a Phase III trial

Gridelli C, Chen T, Ko A, O'Brien ME, Ong TJ, Socinski MA, Postmus PE

Drug Design, Development and Therapy 2018, 12:1445-1451

Published Date: 24 May 2018

In silico and in vivo characterization of cabralealactone, solasodin and salvadorin in a rat model: potential anti-inflammatory agents

Malik A, Arooj M, Butt TT, Zahid S, Zahid F, Jafar TH, Waquar S, Gan SH, Ahmad S, Mirza MU

Drug Design, Development and Therapy 2018, 12:1431-1443

Published Date: 24 May 2018

The anti-cataract molecular mechanism study in selenium cataract rats for baicalin ophthalmic nanoparticles

Li N, Han Z, Li L, Zhang B, Liu Z, Li J

Drug Design, Development and Therapy 2018, 12:1399-1411

Published Date: 23 May 2018

Effects of hemocoagulase agkistrodon on the coagulation factors and its procoagulant activities

Li H, Huang Y, Wu X, Wu T, Cao Y, Wang Q, Qiu Y, Fu W, Zhang Q, Pang J

Drug Design, Development and Therapy 2018, 12:1385-1398

Published Date: 23 May 2018

Antihyperglycemic and anti-inflammatory effects of fermented food paste in high-fat diet and streptozotocin-challenged mice

Zulkawi N, Ng KH, Zamberi NR, Yeap SK, Satharasinghe DA, Tan SW, Ho WY, Abd Rashid NY, Md Lazim MI, Jamaluddin A, Alitheen NB, Long K

Drug Design, Development and Therapy 2018, 12:1373-1383

Published Date: 23 May 2018

REST, not REST4, is a risk factor associated with radiotherapy plus chemotherapy efficacy in glioma

Li C, Zou H, Wang ZF, Tang X, Fan X, Zhang K, Liu J, Li Z

Drug Design, Development and Therapy 2018, 12:1363-1371

Published Date: 22 May 2018

Immature platelets and antiplatelet therapy response to aspirin in Kawasaki disease

Pi L, Che D, Long HF, Fang ZZ, Li JW, Lin SY, Liu YF, Li M, Bao LJ, Li W, Zhang Y, Deng QL, Liu TC, Zhang L, Gu XQ

Drug Design, Development and Therapy 2018, 12:1353-1362

Published Date: 23 May 2018

Assessment of the effects of levosimendan and thymoquinone on lung injury after myocardial ischemia reperfusion in rats

Sezen SC, Kucuk A, Özer A, Kılıç Y, Mardin B, Alkan M, Erkent FD, Arslan M, Ünal Y, Oktar GL, Tosun M

Drug Design, Development and Therapy 2018, 12:1347-1352

Published Date: 22 May 2018

Design and preparation of derivatives of oleanolic and glycyrrhetinic acids with cytotoxic properties

Wang R, Li Y, Huai XD, Zheng QX, Wang W, Li HJ, Huai QY

Drug Design, Development and Therapy 2018, 12:1321-1336

Published Date: 21 May 2018

Glycyrrhizic acid ameliorates myocardial ischemic injury by the regulation of inflammation and oxidative state

Xu CL, Liang CH, Sun WX, Chen JD, Chen XH

Drug Design, Development and Therapy 2018, 12:1311-1319

Published Date: 18 May 2018

Vicenin-2 inhibits Wnt/β-catenin signaling and induces apoptosis in HT-29 human colon cancer cell line

Yang D, Zhang X, Zhang W, Rengarajan T

Drug Design, Development and Therapy 2018, 12:1303-1310

Published Date: 18 May 2018

Rapeseed protein-derived antioxidant peptide RAP alleviates renal fibrosis through MAPK/NF-κB signaling pathways in diabetic nephropathy

Zhang M, Yan Z, Bu L, An C, Wang D, Liu X, Zhang J, Yang W, Deng BC, Xie J, Zhang B

Drug Design, Development and Therapy 2018, 12:1255-1268

Published Date: 15 May 2018

Computer-aided design of amino acid-based therapeutics: a review

Farhadi T, Hashemian SM

Drug Design, Development and Therapy 2018, 12:1239-1254

Published Date: 14 May 2018

Semen Brassicae ameliorates hepatic fibrosis by regulating transforming growth factor-β1/Smad, nuclear factor-κB, and AKT signaling pathways in rats

Cao S, Zheng B, Chen T, Chang X, Yin B, Huang ZH, Shuai P, Han L

Drug Design, Development and Therapy 2018, 12:1205-1213

Published Date: 11 May 2018

Schisandrin B ameliorated chondrocytes inflammation and osteoarthritis via suppression of NF-κB and MAPK signal pathways

Ran J, Ma C, Xu K, Xu L, He Y, Moqbel SAA, Hu P, Jiang L, Chen W, Bao J, Xiong Y, Wu L

Drug Design, Development and Therapy 2018, 12:1195-1204

Published Date: 9 May 2018

Insight into resistance mechanism of anaplastic lymphoma kinase to alectinib and JH-VIII-157-02 caused by G1202R solvent front mutation

Wang H, Wang Y, Guo W, Du B, Huang X, Wu R, Yang B, Lin X, Wu Y

Drug Design, Development and Therapy 2018, 12:1183-1193

Published Date: 9 May 2018

The cytochrome P450 isoenzyme and some new opportunities for the prediction of negative drug interaction in vivo

Sychev DA, Ashraf GM, Svistunov AA, Maksimov ML, Tarasov VV, Chubarev VN, Otdelenov VA, Denisenko NP, Barreto GE, Aliev G

Drug Design, Development and Therapy 2018, 12:1147-1156

Published Date: 8 May 2018

Identification of Mycobacterium tuberculosis BioA inhibitors by using structure-based virtual screening

Singh S, Khare G, Bahal RK, Ghosh PC, Tyagi AK

Drug Design, Development and Therapy 2018, 12:1065-1079

Published Date: 1 May 2018

Inactivation of nuclear factor κB by MIP-based drug combinations augments cell death of breast cancer cells

Subramaniam M, Liew SK, In LLA, Awang K, Ahmed N, Nagoor NH

Drug Design, Development and Therapy 2018, 12:1053-1063

Published Date: 1 May 2018

Pharmacokinetic characteristics of telaprevir in healthy Korean male subjects and comparisons with Japanese

Choi Y, Yoon S, Matsumoto K, Ohta Y, Lee S, Yu KS, Jang IJ

Drug Design, Development and Therapy 2018, 12:1045-1051

Published Date: 30 April 2018

Spotlight on isavuconazole in the treatment of invasive aspergillosis and mucormycosis: design, development, and place in therapy

Jenks JD, Salzer HJ, Prattes J, Krause R, Buchheidt D, Hoenigl M

Drug Design, Development and Therapy 2018, 12:1033-1044

Published Date: 30 April 2018

Symmetric dimeric adamantanes for exploring the structure of two viroporins: influenza virus M2 and hepatitis C virus p7

Mandour YM, Breitinger U, Ma C, Wang J, Boeckler FM, Breitinger HG, Zlotos DP

Drug Design, Development and Therapy 2018, 12:1019-1031

Published Date: 30 April 2018

Astragalus polysaccharides protect cardiac stem and progenitor cells by the inhibition of oxidative stress-mediated apoptosis in diabetic hearts

Chen W, Ju J, Yang Y, Wang H, Chen W, Zhao X, Ye H, Zhang Y

Drug Design, Development and Therapy 2018, 12:943-954

Published Date: 20 April 2018

Comparison of tadalafil pharmacokinetics after administration of a new orodispersible film versus a film-coated tablet

Park SI, Heo SH, Kim G, Chang S, Song KH, Kim MG, Jin EH, Kim J, Lee S, Hong JH

Drug Design, Development and Therapy 2018, 12:935-942

Published Date: 20 April 2018

Chitosan–alginate BSA-gel-capsules for local chemotherapy against drug-resistant breast cancer

Shen H, Li F, Wang D, Yang Z, Yao C, Ye Y, Wang X

Drug Design, Development and Therapy 2018, 12:921-934

Published Date: 19 April 2018

Design, synthesis, and structure–activity relationships of 2-benzylidene-1-indanone derivatives as anti-inflammatory agents for treatment of acute lung injury

Xiao S, Zhang W, Chen H, Fang B, Qiu Y, Chen X, Chen L, Shu S, Zhang Y, Zhao Y, Liu Z, Liang G

Drug Design, Development and Therapy 2018, 12:887-899

Published Date: 19 April 2018

Population pharmacokinetics and dosing optimization of cefathiamidine in children with hematologic infection

Zhi LJ, Wang L, Chen XK, Zhai XY, Wen L, Dong L, Jacqz-Aigrain E, Shi ZR, Zhao W

Drug Design, Development and Therapy 2018, 12:855-862

Published Date: 17 April 2018

Reevaluation of the post-marketing safety of Shuxuening injection based on real-world and evidence-based evaluations

Wang C, Shi QP, Ding F, Jiang XD, Tang W, Yu ML, Zhu JH

Drug Design, Development and Therapy 2018, 12:757-767

Published Date: 5 April 2018

Chrysin suppresses proliferation, migration, and invasion in glioblastoma cell lines via mediating the ERK/Nrf2 signaling pathway

Wang J, Wang HD, Sun KJ, Wang XL, Pan H, Zhu JH, Ji XJ, Li X

Drug Design, Development and Therapy 2018, 12:721-733

Published Date: 3 April 2018

Preparation and in vitro/in vivo evaluation of PLGA microspheres containing norquetiapine for long-acting injection

Park CW, Lee HJ, Oh DW, Kang JH, Han CS, Kim DW

Drug Design, Development and Therapy 2018, 12:711-719

Published Date: 5 April 2018

Organic mononitrites of 1,2-propanediol act as an effective NO-releasing vasodilator in pulmonary hypertension and exhibit no cross-tolerance with nitroglycerin in anesthetized pigs

Nilsson KF, Goździk W, Frostell C, Zieliński S, Zielińska M, Ratajczak K, Skrzypczak P, Rodziewicz S, Albert J, Gustafsson LE

Drug Design, Development and Therapy 2018, 12:685-694

Published Date: 29 March 2018

The role of propranolol as a radiosensitizer in gastric cancer treatment

Liao XH, Chaudhary P, Qiu G, Che XM, Fan L

Drug Design, Development and Therapy 2018, 12:639-645

Published Date: 28 March 2018

Benralizumab in the treatment of severe asthma: design, development and potential place in therapy

Pelaia C, Vatrella A, Bruni A, Terracciano R, Pelaia G

Drug Design, Development and Therapy 2018, 12:619-628

Published Date: 21 March 2018

Rucaparib: a novel PARP inhibitor for BRCA advanced ovarian cancer

Colombo I, Lheureux S, Oza AM

Drug Design, Development and Therapy 2018, 12:605-617

Published Date: 21 March 2018

Tendinopathy: injury, repair, and current exploration

Lipman K, Wang CC, Ting K, Soo C, Zheng Z

Drug Design, Development and Therapy 2018, 12:591-603

Published Date: 20 March 2018

The hydroxypropyl–β-cyclodextrin complexation of toltrazuril for enhancing bioavailability

Zhang L, Liu MX, Lu CC, Ren DD, Fan GQ, Liu C, Liu MJ, Shu G, Peng GN, Yuan ZX, Zhong ZJ, Zhang W, Fu HL

Drug Design, Development and Therapy 2018, 12:583-589

Published Date: 19 March 2018

Bioequivalence of a biosimilar enoxaparin sodium to Clexane® after single 100 mg subcutaneous dose: results of a randomized, double-blind, crossover study in healthy volunteers

Martínez González J, Monreal M, Ayani Almagia I, Llaudó Garín J, Ochoa Díaz de Monasterioguren L, Gutierro Adúriz I

Drug Design, Development and Therapy 2018, 12:575-582

Published Date: 19 March 2018

Pharmacokinetic and bioequivalence study of a telmisartan/S-amlodipine fixed-dose combination (CKD-828) formulation and coadministered telmisartan and S-amlodipine in healthy subjects

Kang WY, Seong SJ, Ohk B, Gwon M, Kim BK, La S, Kim HJ, Cho S, Yoon Y, Yang DH, Lee HW

Drug Design, Development and Therapy 2018, 12:545-553

Published Date: 14 March 2018

Involvement of NF-κB and HSP70 signaling pathways in the apoptosis of MDA-MB-231 cells induced by a prenylated xanthone compound, α-mangostin, from Cratoxylum arborescens [Corrigendum] [Retraction]

Ibrahim MY, Mohd Hashim N, Mohan S, Mohd Ali H, Abdelwahab S, Kamalidehghan B, Ghaderian M, Dehghan F, Salim LZ, Karimian H, Yahayu M, Ee Cheng Lian G, Abdulla M, Farjam AS

Drug Design, Development and Therapy 2018, 12:533-534

Published Date: 13 March 2018

Can dexmedetomidine reduce atrial fibrillation after cardiac surgery? A systematic review and meta-analysis

Zhu ZP, Zhou HM, Ni YJ, Wu C, Zhang CJ, Ling XY

Drug Design, Development and Therapy 2018, 12:521-531

Published Date: 12 March 2018

Inhibitory effect of celecoxib on agomelatine metabolism in vitro and in vivo

He JY, Fang P, Zheng X, Wang CC, Liu TH, Zhang BW, Wen J, Xu RA

Drug Design, Development and Therapy 2018, 12:513-519

Published Date: 9 March 2018

Development of small bisquaternary cholinesterase inhibitors as drugs for pre-treatment of nerve agent poisonings

Kuca K, Karasova JZ, Soukup O, Kassa J, Novotna E, Sepsova V, Horova A, Pejchal J, Hrabinova M, Vodakova E, Jun D, Nepovimova E, Valis M, Musilek K

Drug Design, Development and Therapy 2018, 12:505-512

Published Date: 9 March 2018

Synovial tissue quantitative proteomics analysis reveals paeoniflorin decreases LIFR and ASPN proteins in experimental rheumatoid arthritis

Yang S, Xing ZH, Liu T, Zhou J, Liang QH, Tang T, Cui HJ, Peng WJ, Xiong XG, Wang Y

Drug Design, Development and Therapy 2018, 12:463-473

Published Date: 6 March 2018

Intra-articular platelet-rich plasma versus hyaluronic acid in the treatment of knee osteoarthritis: a meta-analysis

Zhang HF, Wang CG, Li H, Huang YT, Li ZJ

Drug Design, Development and Therapy 2018, 12:445-453

Published Date: 5 March 2018

Efficacy of atorvastatin on the prevention of contrast-induced acute kidney injury: a meta-analysis

Liu L, Liu Y, Wu M, Sun Y, Ma F

Drug Design, Development and Therapy 2018, 12:437-444

Published Date: 2 March 2018

Risk factors for calcineurin inhibitor nephrotoxicity after renal transplantation: a systematic review and meta-analysis

Xia T, Zhu S, Wen Y, Gao S, Li M, Tao X, Zhang F, Chen W

Drug Design, Development and Therapy 2018, 12:417-428

Published Date: 28 February 2018

Magnesium: does it reduce ischemia/reperfusion injury in an adnexal torsion rat model?

Celik Kavak E, Gulcu Bulmus F, Bulmus O, Kavak SB, Kocaman N

Drug Design, Development and Therapy 2018, 12:409-415

Published Date: 28 February 2018

Fasudil inhibits proliferation and migration of Hep-2 laryngeal carcinoma cells

Zhang X, Wu N

Drug Design, Development and Therapy 2018, 12:373-381

Published Date: 23 February 2018

Therapeutic potential of bimatoprost for the treatment of eyebrow hypotrichosis

Chanasumon N, Sriphojanart T, Suchonwanit P

Drug Design, Development and Therapy 2018, 12:365-372

Published Date: 22 February 2018

Formulation design and development of matrix diffusion controlled transdermal drug delivery of glimepiride

Akram MR, Ahmad M, Abrar A, Sarfraz RM, Mahmood A

Drug Design, Development and Therapy 2018, 12:349-364

Published Date: 21 February 2018

Short-term efficacy of intravitreal conbercept in treatment-naive patients with polypoidal choroidal vasculopathy

Peng Y, Zhang X, Li M, Liu B, Mi L, Zuo C, Wen F

Drug Design, Development and Therapy 2018, 12:339-345

Published Date: 19 February 2018

Pharmacokinetics and tolerability of eletriptan hydrobromide in healthy Korean subjects

Kim YK, Shin KH, Alderman J, Yu KS, Jang IJ, Lee S

Drug Design, Development and Therapy 2018, 12:331-337

Published Date: 19 February 2018

Berberine nanoparticles with enhanced in vitro bioavailability: characterization and antimicrobial activity

Sahibzada MUK, Sadiq A, Faidah HS, Khurram M, Amin MU, Haseeb A, Kakar M

Drug Design, Development and Therapy 2018, 12:303-312

Published Date: 14 February 2018

Comparison of the long-term efficacy and safety of generic tacrolimus, Tacrobell, with Prograf in liver transplant recipients

Choi HJ, Kim DG, Kwak BJ, Han JH, Hong TH, You YK

Drug Design, Development and Therapy 2018, 12:295-301

Published Date: 13 February 2018

Asthma and poly(ADP-ribose) polymerase inhibition: a new therapeutic approach

Zaffini R, Gotte G, Menegazzi M

Drug Design, Development and Therapy 2018, 12:281-293

Published Date: 12 February 2018

Reference ranges for antiepileptic drugs revisited: a practical approach to establish national guidelines

Reimers A, Berg JA, Burns ML, Brodtkorb E, Johannessen SI, Johannessen Landmark C

Drug Design, Development and Therapy 2018, 12:271-280

Published Date: 8 February 2018

Experimental and molecular modeling approach to optimize suitable polymers for fabrication of stable fluticasone nanoparticles with enhanced dissolution and antimicrobial activity

Ahmed S, Govender T, Khan I, ur Rehman N, Ali W, Shah SMH, Khan S, Hussain Z, Ullah R, Alsaid MS

Drug Design, Development and Therapy 2018, 12:255-269

Published Date: 5 February 2018

Dysregulation of Neuregulin-1/ErbB signaling in the hippocampus of rats after administration of doxorubicin

Liao D, Guo Y, Xiang D, Dang R, Xu P, Cai H, Cao L, Jiang P

Drug Design, Development and Therapy 2018, 12:231-239

Published Date: 30 January 2018

Durvalumab: an investigational anti-PD-L1 monoclonal antibody for the treatment of urothelial carcinoma

Faiena I, Cummings AL, Crosetti AM, Pantuck AJ, Chamie K, Drakaki A

Drug Design, Development and Therapy 2018, 12:209-215

Published Date: 23 January 2018

Bispecific antibodies: design, therapy, perspectives

Sedykh SE, Prinz VV, Buneva VN, Nevinsky GA

Drug Design, Development and Therapy 2018, 12:195-208

Published Date: 22 January 2018

Anticonvulsant and reproductive toxicological studies of the imidazole-based histamine H3R antagonist 2-18 in mice

Bastaki SM, Abdulrazzaq YM, Shafiullah M, Więcek M, Kieć-Kononowicz K, Sadek B

Drug Design, Development and Therapy 2018, 12:179-194

Published Date: 19 January 2018

Involvement of microRNA-146a in diabetic peripheral neuropathy through the regulation of inflammation

Feng Y, Chen L, Luo Q, Wu M, Chen Y, Shi X

Drug Design, Development and Therapy 2018, 12:171-177

Published Date: 17 January 2018

Efficacy and side effects of intravenous theophylline in acute asthma: a systematic review and meta-analysis

Mahemuti G, Zhang H, Li J, Tieliwaerdi N, Ren L

Drug Design, Development and Therapy 2018, 12:99-120

Published Date: 10 January 2018

Peptides derived from Plasmodium falciparum leucine-rich repeat 1 bind to serine/threonine phosphatase type 1 and inhibit parasite growth in vitro

Pierrot C, Zhang X, Zanghi G, Fréville A, Rebollo A, Khalife J

Drug Design, Development and Therapy 2018, 12:85-88

Published Date: 9 January 2018

Quantitative assessment of the effects of chitosan intervention on blood pressure control

Huang H, Zou Y, Chi H

Drug Design, Development and Therapy 2018, 12:67-75

Published Date: 28 December 2017

The oral bioavailability, excretion and cytochrome P450 inhibition properties of epiberberine: an in vivo and in vitro evaluation

Chen N, Yang X, Guo C, Bi X, Chen J, Chen H, Li H, Lin H, Zhang Y

Drug Design, Development and Therapy 2018, 12:57-65

Published Date: 28 December 2017

Portulaca oleracea L. alleviates liver injury in streptozotocin-induced diabetic mice

Zheng G, Mo F, Ling C, Peng H, Gu W, Li M, Chen Z

Drug Design, Development and Therapy 2018, 12:47-55

Published Date: 28 December 2017

Clinical features of hypophosphatemic osteomalacia induced by long-term low-dose adefovir dipivoxil

Zhu S, Yang YH, Gao RW, Li R, Zou YZ, Feng L, Zhang B

Drug Design, Development and Therapy 2018, 12:41-45

Published Date: 27 December 2017

Leishmaniasis in humans: drug or vaccine therapy?

Ghorbani M, Farhoudi R

Drug Design, Development and Therapy 2018, 12:25-40

Published Date: 22 December 2017

Intra-articular collagenase injection increases range of motion in a rat knee flexion contracture model

Wong K, Trudel G, Laneuville O

Drug Design, Development and Therapy 2018, 12:15-24

Published Date: 21 December 2017

HX575: established biosimilarity in the treatment of renal anemia and 10 years of clinical experience

Dellanna F, Goldsmith D, Krendyukov A, Seidl A, Höbel N, Combe C

Drug Design, Development and Therapy 2018, 12:9-14

Published Date: 18 December 2017

Resveratrol as a potential therapeutic drug for respiratory system diseases

Zhu X, Lei X, Dong W

Drug Design, Development and Therapy 2017, 11:3591-3598

Published Date: 15 December 2017

EUREKA study – the evaluation of real-life use of a biophotonic system in chronic wound management: an interim analysis

Romanelli M, Piaggesi A, Scapagnini G, Dini V, Janowska A, Iacopi E, Scarpa C, Fauverghe S, Bassetto F

Drug Design, Development and Therapy 2017, 11:3551-3558

Published Date: 11 December 2017

Comparative pharmacokinetics of a fixed-dose combination vs concomitant administration of telmisartan and S-amlodipine in healthy adult volunteers

Oh M, Park SE, Ghim JL, Choi YK, Shim EJ, Shin JG, Kim EY

Drug Design, Development and Therapy 2017, 11:3543-3550

Published Date: 11 December 2017

Gut microbiota–derived short-chain fatty acids and kidney diseases

Li L, Ma L, Fu P

Drug Design, Development and Therapy 2017, 11:3531-3542

Published Date: 11 December 2017

Regulation profile of the intestinal peptide transporter 1 (PepT1)

Wang CY, Liu S, Xie XN, Tan ZR

Drug Design, Development and Therapy 2017, 11:3511-3517

Published Date: 8 December 2017

Functional assessment of CYP3A4 allelic variants on lidocaine metabolism in vitro

Fang P, Tang P, Xu R, Zheng X, Wen J, Bao S, Cai J, Hu G

Drug Design, Development and Therapy 2017, 11:3503-3510

Published Date: 7 December 2017

Anacetrapib as a potential cardioprotective strategy

Di Bartolo BA, Nicholls SJ

Drug Design, Development and Therapy 2017, 11:3497-3502

Published Date: 7 December 2017

Involvement of poly(ADP-ribose) polymerase-1 in development of spinal cord injury in Chinese individuals: a Chinese clinical study

Meng Q, Yang G, Li R, Nie J, Zhou W, Yu H, Chen B, Jiang L, Shang J

Drug Design, Development and Therapy 2017, 11:3491-3495

Published Date: 6 December 2017

Preparation and evaluation of RGD and TAT co-modified docetaxel-loaded liposome

Zhu R, Tian Y

Drug Design, Development and Therapy 2017, 11:3481-3489

Published Date: 6 December 2017

Variability in the therapeutic management of advanced ovarian cancer patients: a five-country survey of oncologists

Audibert C, Perlaky A, Stuntz M, Glass D

Drug Design, Development and Therapy 2017, 11:3471-3479

Published Date: 6 December 2017

Hepatoprotective effect of calculus bovis sativus on nonalcoholic fatty liver disease in mice by inhibiting oxidative stress and apoptosis of hepatocytes

He WX, Xu YJ, Zhang CL, Lu JL, Li J, Xiang D, Yang JY, Chang MJ, Liu D

Drug Design, Development and Therapy 2017, 11:3449-3460

Published Date: 5 December 2017

High-dose atorvastatin versus moderate dose on early vascular protection after ST-elevation myocardial infarction

Gavazzoni M, Gorga E, Derosa G, Maffioli P, Metra M, Raddino R

Drug Design, Development and Therapy 2017, 11:3425-3434

Published Date: 4 December 2017

A novel transdermal nanoethosomal gel of betahistine dihydrochloride for weight gain control: in-vitro and in-vivo characterization

El-Menshawe SF, Ali AA, Halawa AA, Srag El-Din AS

Drug Design, Development and Therapy 2017, 11:3377-3388

Published Date: 28 November 2017

The coexpression of multi-immune inhibitory receptors on T lymphocytes in primary non-small-cell lung cancer

Guo WJ, Liu SH, Zhang XL, Chen YT, Qian RL, Zou ZY, Chen X, Luo P

Drug Design, Development and Therapy 2017, 11:3367-3376

Published Date: 28 November 2017

Andrographolide enhanced 5-fluorouracil-induced antitumor effect in colorectal cancer via inhibition of c-MET pathway

Su M, Qin B, Liu F, Chen Y, Zhang R

Drug Design, Development and Therapy 2017, 11:3333-3341

Published Date: 23 November 2017

Fentanyl-induced respiratory depression is attenuated in pregnant patients

Cao X, Liu S, Sun J, Yu M, Fang Y, Ding Z

Drug Design, Development and Therapy 2017, 11:3325-3332

Published Date: 22 November 2017

Severe hypertriglyceridemia and colchicine intoxication following suicide attempt

Lev S, Snyder D, Azran C, Zolotarsky V, Dahan A

Drug Design, Development and Therapy 2017, 11:3321-3324

Published Date: 22 November 2017

Anticancer effect of dentatin and dentatin-hydroxypropyl-β-cyclodextrin complex on human colon cancer (HT-29) cell line

AL-Abboodi AS, Rasedee A, Abdul AB, Taufiq-Yap YH, Alkaby WA, Ghaji MS, Waziri PM, Al-Qubaisi MS

Drug Design, Development and Therapy 2017, 11:3309-3319

Published Date: 23 November 2017

Pharmacodynamic testing and new validated HPLC method to assess the interchangeability between multi-source orlistat capsules

Zaid AN, Zohud N, E'layan B, Aburadi T, Jaradat N, Ali I, Hussein F, Ghanem M, Qaddomi A, Abu Zaaror Y

Drug Design, Development and Therapy 2017, 11:3291-3298

Published Date: 21 November 2017

In silico-based identification of human α-enolase inhibitors to block cancer cell growth metabolically

Lung J, Chen KL, Hung CH, Chen CC, Hung MS, Lin YC, Wu CY, Lee KD, Shih NY, Tsai YH

Drug Design, Development and Therapy 2017, 11:3281-3290

Published Date: 16 November 2017

Differences of statin activity in 2D and 3D pancreatic cancer cell cultures

Paškevičiūtė M, Petrikaitė V

Drug Design, Development and Therapy 2017, 11:3273-3280

Published Date: 16 November 2017

Role of nebulized glycopyrrolate in the treatment of chronic obstructive pulmonary disease

Santus P, Radovanovic D, Cristiano A, Valenti V, Rizzi M

Drug Design, Development and Therapy 2017, 11:3257-3271

Published Date: 15 November 2017

Novel production method of innovative antiangiogenic and antitumor small peptides in Escherichia coli

Setrerrahmane S, Yu J, Hao J, Zheng H, Xu H

Drug Design, Development and Therapy 2017, 11:3207-3220

Published Date: 8 November 2017

Impact of baseline blood pressure on the magnitude of blood pressure lowering by nifedipine gastrointestinal therapeutic system: refreshing the Wilder’s principle

Hu HJ, Zhang JD, Wang Y, Tian ZJ, Liu DM, Zhang GM, Gu GQ, Zheng HM, Xie RQ, Cui W

Drug Design, Development and Therapy 2017, 11:3179-3186

Published Date: 6 November 2017

Baracle® vs Baraclude® for 48 weeks in patients with treatment-naïve chronic hepatitis B: a comparison of efficacy and safety

Kim DY, Kim JH, Tak WY, Yeon JE, Lee JH, Yoon JH, Lee YJ, Lee BS, Han BH, Lee HC

Drug Design, Development and Therapy 2017, 11:3145-3152

Published Date: 31 October 2017

Severe eosinophilic asthma: from the pathogenic role of interleukin-5 to the therapeutic action of mepolizumab

Pelaia C, Vatrella A, Busceti MT, Gallelli L, Terracciano R, Savino R, Pelaia G

Drug Design, Development and Therapy 2017, 11:3137-3144

Published Date: 30 October 2017

Vitamin D levels in systemic sclerosis patients: a meta-analysis

An L, Sun M, Chen F, Li J

Drug Design, Development and Therapy 2017, 11:3119-3125

Published Date: 27 October 2017

High-dose dexamethasone induced LPS-stimulated rat alveolar macrophages apoptosis

Zeng S, Qiao H, Lv XW, Fan D, Liu T, Xie D

Drug Design, Development and Therapy 2017, 11:3097-3104

Published Date: 25 October 2017

Enhanced antitumor efficacy of poly(D,L-lactide-co-glycolide)-based methotrexate-loaded implants on sarcoma 180 tumor-bearing mice

Gao L, Xia L, Zhang R, Duan D, Liu X, Xu J, Luo L

Drug Design, Development and Therapy 2017, 11:3065-3075

Published Date: 20 October 2017

10H-3,6-Diazaphenothiazine induces G2/M phase cell cycle arrest and caspase-dependent apoptosis and inhibits cell invasion of A2780 ovarian carcinoma cells through the regulation of NF-κB and (BIRC6-XIAP) complexes

Zhang J, Ming C, Zhang W, Okechukwu PN, Morak-Młodawska B, Pluta K, Jeleń M, Akim AM, Ang KP, Ooi KK

Drug Design, Development and Therapy 2017, 11:3045-3063

Published Date: 24 October 2017

Failure mode and effects analysis drastically reduced potential risks in clinical trial conduct

Lee H, Lee H, Baik J, Kim HJ, Kim R

Drug Design, Development and Therapy 2017, 11:3035-3043

Published Date: 19 October 2017

Edaravone inhibits pressure overload-induced cardiac fibrosis and dysfunction by reducing expression of angiotensin II AT1 receptor

Zhang WW, Bai F, Wang J, Zheng RH, Yang LW, James EA, Zhao ZQ

Drug Design, Development and Therapy 2017, 11:3019-3033

Published Date: 16 October 2017

Amelioration of collagen-induced arthritis using antigen-loaded dendritic cells modified with NF-κB decoy oligodeoxynucleotides

Jiang HM, Hu HG, Zhang YL, Yue P, Ning LC, Zhou Y, Shi P, Yuan R

Drug Design, Development and Therapy 2017, 11:2997-3007

Published Date: 13 October 2017

5H-benzo[h]thiazolo[2,3-b]quinazolines ameliorate NDEA-induced hepatocellular carcinogenesis in rats through IL-6 downregulation along with oxidative and metabolic stress reduction

Keshari AK, Singh AK, Kumar U, Raj V, Rai A, Kumar P, Kumar D, Maity B, Nath S, Prakash A, Saha S

Drug Design, Development and Therapy 2017, 11:2981-2995

Published Date: 13 October 2017

Protective effect of DA-9401 in finasteride-induced apoptosis in rat testis: inositol requiring kinase 1 and c-Jun N-terminal kinase pathway

Soni KK, Shin YS, Choi BR, Karna KK, Kim HK, Lee SW, Kim CY, Park JK

Drug Design, Development and Therapy 2017, 11:2969-2979

Published Date: 11 October 2017

Halofuginone ameliorates inflammation in severe acute hepatitis B virus (HBV)-infected SD rats through AMPK activation

Zhan WL, Kang YH, Chen N, Mao CS, Kang Y, Shang J

Drug Design, Development and Therapy 2017, 11:2947-2955

Published Date: 10 October 2017

Short vs prolonged dual antiplatelet treatment upon endovascular stenting of peripheral arteries

Kronlage M, Wassmann M, Vogel B, Müller OJ, Blessing E, Katus H, Erbel C

Drug Design, Development and Therapy 2017, 11:2937-2945

Published Date: 6 October 2017

Spotlight on ertugliflozin and its potential in the treatment of type 2 diabetes: evidence to date

Cinti F, Moffa S, Impronta F, Cefalo CMA, Sun VA, Sorice GP, Mezza T, Giaccari A

Drug Design, Development and Therapy 2017, 11:2905-2919

Published Date: 3 October 2017

Current perspective on rituximab in rheumatic diseases

Schioppo T, Ingegnoli F

Drug Design, Development and Therapy 2017, 11:2891-2904

Published Date: 3 October 2017

The new era of nanotechnology, an alternative to change cancer treatment

Jurj A, Braicu C, Pop LA, Tomuleasa C, Gherman CD, Berindan-Neagoe I

Drug Design, Development and Therapy 2017, 11:2871-2890

Published Date: 27 September 2017

Downregulation of A20 increases the cytotoxicity of IFN-γ in hepatocellular carcinoma cells

Yin L, Fang Z, Shen N, Qiu Y, Li A, Zhang Y

Drug Design, Development and Therapy 2017, 11:2841-2850

Published Date: 26 September 2017

Eluxadoline in the treatment of diarrhea-predominant irritable bowel syndrome

Özdener AE, Rivkin A

Drug Design, Development and Therapy 2017, 11:2827-2840

Published Date: 26 September 2017

Axitinib in the treatment of renal cell carcinoma: design, development, and place in therapy

Bellesoeur A, Carton E, Alexandre J, Goldwasser F, Huillard O

Drug Design, Development and Therapy 2017, 11:2801-2811

Published Date: 21 September 2017

Dexmedetomidine reduces the neuronal apoptosis related to cardiopulmonary bypass by inhibiting activation of the JAK2–STAT3 pathway

Chen Y, Zhang X, Zhang B, He G, Zhou L, Xie Y

Drug Design, Development and Therapy 2017, 11:2787-2799

Published Date: 26 September 2017

Biodegradable rifampicin-releasing coating of surgical meshes for the prevention of bacterial infections

Reinbold J, Hierlemann T, Urich L, Uhde AK, Müller I, Weindl T, Vogel U, Schlensak C, Wendel HP, Krajewski S

Drug Design, Development and Therapy 2017, 11:2753-2762

Published Date: 18 September 2017

The roles of epigallocatechin-3-gallate in the treatment of neuropathic pain: an update on preclinical in vivo studies and future perspectives

Bimonte S, Cascella M, Schiavone V, Mehrabi-Kermani F, Cuomo A

Drug Design, Development and Therapy 2017, 11:2737-2742

Published Date: 13 September 2017

Pharmacokinetic and safety evaluation of MB12066, an NQO1 substrate

Lee HW, Seong SJ, Ohk B, Kang WY, Gwon MR, Kim BK, Kim HJ, Yoon YR

Drug Design, Development and Therapy 2017, 11:2719-2725

Published Date: 13 September 2017

Localized neuropathic pain: an expert consensus on local treatments

Pickering G, Martin E, Tiberghien F, Delorme C, Mick G

Drug Design, Development and Therapy 2017, 11:2709-2718

Published Date: 13 September 2017

Metal organic frameworks as a drug delivery system for flurbiprofen

AL Haydar M, Abid HR, Sunderland B, Wang S

Drug Design, Development and Therapy 2017, 11:2685-2695

Published Date: 11 September 2017

Cissus quadrangularis inhibits IL-1β induced inflammatory responses on chondrocytes and alleviates bone deterioration in osteotomized rats via p38 MAPK signaling [Corrigendum]

Kanwar JR, Samarasinghe RM, Kumar K, Arya R, Sanjeev S, Zhou SF, Sasidharan S, Kanwar RK

Drug Design, Development and Therapy 2017, 11:2683-2684

Published Date: 12 September 2017

Extended infusion versus intermittent infusion of imipenem in the treatment of ventilator-associated pneumonia

Ibrahim MM, Tammam TF, Ebaed MED, Sarhan HA, Gad GF, Hussein AK

Drug Design, Development and Therapy 2017, 11:2677-2682

Published Date: 6 September 2017

Palatability and physical properties of potassium-binding resin RDX7675: comparison with sodium polystyrene sulfonate

Zann V, McDermott J, Jacobs JW, Davidson JP, Lin F, Korner P, Blanks RC, Rosenbaum DP

Drug Design, Development and Therapy 2017, 11:2663-2673

Published Date: 6 September 2017

In vitro inhibitory activities of magnolol against Candida spp.

Zhou PR, Fu JY, Hua H, Liu XS

Drug Design, Development and Therapy 2017, 11:2653-2661

Published Date: 6 September 2017

Radium 223 dichloride for prostate cancer treatment

Deshayes E, Roumiguie M, Thibault C, Beuzeboc P, Cachin F, Hennequin C, Huglo D, Rozet F, Kassab-Chahmi D, Rebillard X, Houédé N

Drug Design, Development and Therapy 2017, 11:2643-2651

Published Date: 6 September 2017

Recent developments in the clinical pharmacology of rolapitant: subanalyses in specific populations

Rapoport BL, Aapro M, Chasen MR, Jordan K, Navari RM, Schnadig I, Schwartzberg L

Drug Design, Development and Therapy 2017, 11:2621-2629

Published Date: 5 September 2017

Protective role of quercetin against manganese-induced injury in the liver, kidney, and lung; and hematological parameters in acute and subchronic rat models

Bahar E, Lee GH, Bhattarai KR, Lee HY, Kim HK, Handigund M, Choi MK, Han SY, Chae HJ, Yoon H

Drug Design, Development and Therapy 2017, 11:2605-2619

Published Date: 5 September 2017

Puerarin transport across rat nasal epithelial cells and the influence of compatibility with paeoniflorin and menthol

Zhang L, Du S, Lu Y, Liu C, Wu H, Tian Z, Wang M, Yang C

Drug Design, Development and Therapy 2017, 11:2581-2593

Published Date: 1 September 2017

Quantum mechanics implementation in drug-design workflows: does it really help?

Arodola OA, Soliman MES

Drug Design, Development and Therapy 2017, 11:2551-2564

Published Date: 31 August 2017

New insight into the pathogenesis of nail psoriasis and overview of treatment strategies

Ventura A, Mazzeo M, Gaziano R, Galluzzo M, Bianchi L, Campione E

Drug Design, Development and Therapy 2017, 11:2527-2535

Published Date: 30 August 2017

Secondary prevention of major cerebrovascular events with seven different statins: a multi-treatment meta-analysis

Zhong P, Wu D, Ye X, Wu Y, Li T, Tong S, Liu X

Drug Design, Development and Therapy 2017, 11:2517-2526

Published Date: 30 August 2017

Therapy with pamidronate in children with osteogenesis imperfecta

Marginean O, Tamasanu RC, Mang N, Mozos I, Brad GF

Drug Design, Development and Therapy 2017, 11:2507-2515

Published Date: 28 August 2017

Advances in the delivery of buprenorphine for opioid dependence

Rosenthal RN, Goradia VV

Drug Design, Development and Therapy 2017, 11:2493-2505

Published Date: 28 August 2017

Paeoniflorin suppresses pancreatic cancer cell growth by upregulating HTRA3 expression

Li YJ, Gong LL, Qi RL, Sun Q, Xia XX, He HH, Ren JS, Zhu ON, Zhuo DB

Drug Design, Development and Therapy 2017, 11:2481-2491

Published Date: 23 August 2017