Back to Journals » Drug Design, Development and Therapy » Volume 14 » default

Drug Design, Development and Therapy


Archive: Volume 14, 2020

Metalloprotoporphyrin Inhibition of HCV NS3-4A Protease: Structure–Activity Relationships

Hu K, Zhu Z, Mathahs MM, Tran H, Bommer J, Testa CA, Schmidt WN

Drug Design, Development and Therapy 2020, 14:757-771

Published Date: 24 February 2020

NVP-BSK805, an Inhibitor of JAK2 Kinase, Significantly Enhances the Radiosensitivity of Esophageal Squamous Cell Carcinoma in vitro and in vivo

Hua Y, Wang W, Zheng X, Yang L, Wu H, Hu Z, Li Y, Yue J, Jiang Z, Zhang X, Hou Q, Wu S

Drug Design, Development and Therapy 2020, 14:745-755

Published Date: 24 February 2020

Synthesis, Characterization, and Pharmacodynamics Study of Enrofloxacin Mesylate

Pei L, Yang W, Fu J, Liu M, Zhang T, Li D, Huang R, Zhang L, Peng G, Shu G, Yuan Z, Lin J, Zhang W, Zhong Z, Zhao L, Fu H

Drug Design, Development and Therapy 2020, 14:715-730

Published Date: 24 February 2020

Anti-Inflammatory Activity of Sanjie Zhentong Capsule Assessed By Network Pharmacology Analysis of Adenomyosis Treatment 

Du L, Du DH, Chen B, Ding Y, Zhang T, Xiao W

Drug Design, Development and Therapy 2020, 14:697-713

Published Date: 20 February 2020

Colon Targeting of Naringin for Enhanced Cytoprotection Against Indomethacin-Induced Colitis in Rabbits

El Naggar EE, Mohamed EA, Borg TM, El-Sheakh AR, Hamed MF

Drug Design, Development and Therapy 2020, 14:677-696

Published Date: 19 February 2020

Impacts of CYP2C19 Polymorphism and Clopidogrel Dosing on in-Stent Restenosis: A Retrospective Cohort Study in Chinese Patients

Zhang M, Wang J, Zhang Y, Zhang P, Jia Z, Ren M, Jia X, Ma L, Gao M, Hou Y

Drug Design, Development and Therapy 2020, 14:669-676

Published Date: 19 February 2020

A Comparative Study of Inhaled Nitric Oxide and an Intravenously Administered Nitric Oxide Donor in Acute Pulmonary Hypertension

Stene Hurtsén A, Zorikhin Nilsson I, Dogan EM, Nilsson KF

Drug Design, Development and Therapy 2020, 14:635-645

Published Date: 17 February 2020

Hydrogen Sulfide Protects Against High Glucose-Induced Human Umbilical Vein Endothelial Cell Injury Through Activating PI3K/Akt/eNOS Pathway

Lin F, Yang Y, Wei S, Huang X, Peng Z, Ke X, Zeng Z, Song Y

Drug Design, Development and Therapy 2020, 14:621-633

Published Date: 14 February 2020

Pharmacokinetics and Tolerability of Single and Multiple Intravenous Doses of Cefotetan Disodium in Healthy Chinese Volunteers

Liu J, Zhai Y, Wu L, Wu G, Zheng Y, Hu X, Shentu J

Drug Design, Development and Therapy 2020, 14:613-620

Published Date: 13 February 2020

Silibinin Augments the Antifibrotic Effect of Valsartan Through Inactivation of TGF-β1 Signaling in Kidney

Liu R, Wang Q, Ding Z, Zhang X, Li Y, Zang Y, Zhang G

Drug Design, Development and Therapy 2020, 14:603-611

Published Date: 13 February 2020

Lysosomal Acid Lipase Deficiency: Therapeutic Options

Pastores GM, Hughes DA

Drug Design, Development and Therapy 2020, 14:591-601

Published Date: 11 February 2020

Regulations of miR-183-5p and Snail-Mediated Shikonin-Reduced Epithelial-Mesenchymal Transition in Cervical Cancer Cells

Tang Q, Liu L, Zhang H, Xiao J, Hann SS

Drug Design, Development and Therapy 2020, 14:577-589

Published Date: 11 February 2020

Minoxidil and Its Use in Hair Disorders: A Review [Corrigendum]

Suchonwanit P, Thammarucha S, Leerunyakul K

Drug Design, Development and Therapy 2020, 14:575-576

Published Date: 10 February 2020

Optimization of a Benzothiazole Indolene Scaffold Targeting Bacterial Cell Wall Assembly

Chauhan J, Yu W, Cardinale S, Opperman TJ, MacKerell AD Jr, Fletcher S, de Leeuw EPH

Drug Design, Development and Therapy 2020, 14:567-574

Published Date: 10 February 2020

Focus on Notoginsenoside R1 in Metabolism and Prevention Against Human Diseases

Liu H, Yang J, Yang W, Hu S, Wu Y, Zhao B, Hu H, Du S

Drug Design, Development and Therapy 2020, 14:551-565

Published Date: 7 February 2020

Potential Use of Microbial Surfactant in Microemulsion Drug Delivery System: A Systematic Review

Ohadi M, Shahravan A, Dehghannoudeh N, Eslaminejad T, Banat IM, Dehghannoudeh G

Drug Design, Development and Therapy 2020, 14:541-550

Published Date: 5 February 2020

In silico Analysis, Molecular Docking, Molecular Dynamic, Cloning, Expression and Purification of Chimeric Protein in Colorectal Cancer Treatment [Erratum]

Dana H, Mahmoodi Chalbatani G, Gharagouzloo E, Miri SR, Memari F, Rasoolzadeh R, Zinatizadeh MR, Kheirandish Zarandi P, Marmari V

Drug Design, Development and Therapy 2020, 14:539-540

Published Date: 5 February 2020

Panax Notoginseng Ameliorates Podocyte EMT by Targeting the Wnt/β-Catenin Signaling Pathway in STZ-Induced Diabetic Rats

Xie L, Zhai R, Chen T, Gao C, Xue R, Wang N, Wang J, Xu Y, Gui D

Drug Design, Development and Therapy 2020, 14:527-538

Published Date: 5 February 2020

Design, Synthesis and Biological Evaluation of New HDAC1 and HDAC2 Inhibitors Endowed with Ligustrazine as a Novel Cap Moiety

Al-Sanea MM, Gotina L, Mohamed MFA, Grace Thomas Parambi D, Gomaa HAM, Mathew B, Youssif BGM, Alharbi KS, Elsayed ZM, Abdelgawad MA, Eldehna WM

Drug Design, Development and Therapy 2020, 14:497-508

Published Date: 4 February 2020

New Isatin–Indole Conjugates: Synthesis, Characterization, and a Plausible Mechanism of Their in vitro Antiproliferative Activity

Al-Wabli RI, Almomen AA, Almutairi MS, Keeton AB, Piazza GA, Attia MI

Drug Design, Development and Therapy 2020, 14:483-495

Published Date: 3 February 2020

Metformin Activates the AMPK-mTOR Pathway by Modulating lncRNA TUG1 to Induce Autophagy and Inhibit Atherosclerosis

You G, Long X, Song F, Huang J, Tian M, Xiao Y, Deng S, Wu Q

Drug Design, Development and Therapy 2020, 14:457-468

Published Date: 3 February 2020

Development of a Novel Controlled-Release Tablet of Pregabalin: Formulation Variation and Pharmacokinetics in Dogs and Humans

Kim KH, Lim SH, Shim CR, Park J, Song WH, Kwon MC, Lee JH, Park JS, Choi HG

Drug Design, Development and Therapy 2020, 14:445-456

Published Date: 30 January 2020

Calycosin Influences the Metabolism of Five Probe Drugs in Rats

Wu M, Lin Y, Wei Y, Du H, Ying X, Tan W, Tang B

Drug Design, Development and Therapy 2020, 14:429-434

Published Date: 29 January 2020

A New Validated HPLC-MS/MS Method for Quantification and Pharmacokinetic Evaluation of Dovitinib, a Multi-Kinase Inhibitor, in Mouse Plasma

AlRabiah H, Kadi AA, Aljohar HI, Attwa MW, Al-Shakliah NS, Attia SM, Mostafa GAE

Drug Design, Development and Therapy 2020, 14:407-415

Published Date: 28 January 2020

Reversible Small Molecule Inhibitors of MAO A and MAO B with Anilide Motifs

Hagenow J, Hagenow S, Grau K, Khanfar M, Hefke L, Proschak E, Stark H

Drug Design, Development and Therapy 2020, 14:371-393

Published Date: 28 January 2020

In silico Analysis, Molecular Docking, Molecular Dynamic, Cloning, Expression and Purification of Chimeric Protein in Colorectal Cancer Treatment

Dana H, Mahmoodi Chalbatani G, Gharagouzloo E, Miri SR, Memari F, Rasoolzadeh R, Zinatizadeh MR, Kheirandish Zarandi P, Marmari V

Drug Design, Development and Therapy 2020, 14:309-329

Published Date: 23 January 2020

Progress in Understanding the Molecular Mechanisms Underlying the Antitumour Effects of Ivermectin

Liu J, Zhang K, Cheng L, Zhu H, Xu T

Drug Design, Development and Therapy 2020, 14:285-296

Published Date: 21 January 2020

Apatinib in Patients with Relapsed or Refractory Diffuse Large B Cell Lymphoma: A Phase II, Open-Label, Single-Arm, Prospective Study

Ma X, Li L, Zhang L, Fu X, Li X, Wang X, Wu J, Sun Z, Zhang X, Feng X, Chang Y, Zhou Z, Nan F, Zhang J, Li Z, Zhang M

Drug Design, Development and Therapy 2020, 14:275-284

Published Date: 22 January 2020

The Impact of Loading Dose on Outcome in Stroke Patients Receiving Low-Dose Tissue Plasminogen Activator Thrombolytic Therapy

Wong YS, Sung SF, Wu CS, Hsu YC, Su YH, Hung LC, Ong CT

Drug Design, Development and Therapy 2020, 14:257-263

Published Date: 17 January 2020

Enhancing Betulinic Acid Dissolution Rate and Improving Antitumor Activity via Nanosuspension Constructed by Anti-Solvent Technique

Li S, Zhang J, Fang Y, Yi J, Lu Z, Chen Y, Guo B

Drug Design, Development and Therapy 2020, 14:243-256

Published Date: 16 January 2020

Electrospun PLA Fibers Containing Metronidazole for Periodontal Disease

Budai-Szűcs M, Léber A, Cui L, Józó M, Vályi P, Burián K, Kirschweng B, Csányi E, Pukánszky B

Drug Design, Development and Therapy 2020, 14:233-242

Published Date: 16 January 2020

Discovery of a Novel Benzenesulfonamide Analogue That Inhibits Proliferation and Metastasis Against Ovarian Cancer OVCAR-8 Cells

Jia Y, Li M, Cao Y, Feng W, Li X, Xue W, Shi H

Drug Design, Development and Therapy 2020, 14:207-216

Published Date: 15 January 2020

Baicalin Ameliorates Dexamethasone-Induced Osteoporosis by Regulation of the RANK/RANKL/OPG Signaling Pathway

Zhao Y, Wang HL, Li TT, Yang F, Tzeng CM

Drug Design, Development and Therapy 2020, 14:195-206

Published Date: 15 January 2020

Curcumin Combined with Thalidomide Reduces Expression of STAT3 and Bcl-xL, Leading to Apoptosis in Acute Myeloid Leukemia Cell Lines

Mohammadi Kian M, Salemi M, Bahadoran M, Haghi A, Dashti N, Mohammadi S, Rostami S, Chahardouli B, Babakhani D, Nikbakht M

Drug Design, Development and Therapy 2020, 14:185-194

Published Date: 15 January 2020

Isoborneol Attenuates Low-Density Lipoprotein Accumulation and Foam Cell Formation in Macrophages

Wang Y, Li Z, Liu B, Wu R, Gong H, Su Z, Zhang S

Drug Design, Development and Therapy 2020, 14:167-173

Published Date: 15 January 2020

Aloin Inhibits the Proliferation and Migration of Gastric Cancer Cells by Regulating NOX2–ROS-Mediated Pro-Survival Signal Pathways

Wang Z, Tang T, Wang S, Cai T, Tao H, Zhang Q, Qi S, Qi Z

Drug Design, Development and Therapy 2020, 14:145-155

Published Date: 14 January 2020

Metabolic Stability Assessment of Larotrectinib Using Liquid Chromatography Tandem Mass Spectrometry

Attwa MW, Kadi AA, Darwish HW

Drug Design, Development and Therapy 2020, 14:111-119

Published Date: 10 January 2020

Suitability of Amoxicillin–Clavulanic Acid for Administration via Prolonged Infusion

Fawaz S, Dixon B, Barton S, Mohamed A, Nabhani-Gebara S

Drug Design, Development and Therapy 2020, 14:103-109

Published Date: 10 January 2020

Curcumin Attenuates Oxaliplatin-Induced Liver Injury and Oxidative Stress by Activating the Nrf2 Pathway

Lu Y, Wu S, Xiang B, Li L, Lin Y

Drug Design, Development and Therapy 2020, 14:73-85

Published Date: 9 January 2020

Sappanone A Protects Against Myocardial Ischemia Reperfusion Injury by Modulation of Nrf2

Shi X, Tao G, Ji L, Tian G

Drug Design, Development and Therapy 2020, 14:61-71

Published Date: 8 January 2020

Engineering of Naproxen Loaded Polymer Hybrid Enteric Microspheres for Modified Release Tablets: Development, Characterization, in silico Modelling and in vivo Evaluation

Hameed HA, Khan S, Shahid M, Ullah R, Bari A, Ali SS, Hussain Z, Sohail M, Khan SU, Htar TT

Drug Design, Development and Therapy 2020, 14:27-41

Published Date: 7 January 2020

NMMHC IIA Inhibition Ameliorates Cerebral Ischemic/Reperfusion-Induced Neuronal Apoptosis Through Caspase-3/ROCK1/MLC Pathway

Wang GY, Wang TZ, Zhang YY, Li F, Yu BY, Kou JP

Drug Design, Development and Therapy 2020, 14:13-25

Published Date: 6 January 2020