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Drug Design, Development and Therapy


Archive: Volume 14, 2020

A Review on the Role of Denosumab in Fracture Prevention

Pang KL, Low NY, Chin KY

Drug Design, Development and Therapy 2020, 14:4029-4051

Published Date: 1 October 2020

Multifunctional Islet Transplantation Hydrogel Encapsulating A20 High-Expressing Islets

Bai X, Pei Q, Pu C, Chen Y, He S, Wang B

Drug Design, Development and Therapy 2020, 14:4021-4027

Published Date: 29 September 2020

Umbelliferone Inhibits Spermatogenic Defects and Testicular Injury in Lead-Intoxicated Rats by Suppressing Oxidative Stress and Inflammation, and Improving Nrf2/HO-1 Signaling

Alotaibi MF, Al-Joufi F, Abou Seif HS, Alzoghaibi MA, Djouhri L, Ahmeda AF, Mahmoud AM

Drug Design, Development and Therapy 2020, 14:4003-4019

Published Date: 29 September 2020

Challenges for Mesenchymal Stem Cell-Based Therapy for COVID-19

Li C, Zhao H, Wang B

Drug Design, Development and Therapy 2020, 14:3995-4001

Published Date: 29 September 2020

DPP-4 Inhibitor Linagliptin Ameliorates Oxidized LDL-Induced THP-1 Macrophage Foam Cell Formation and Inflammation

Wang H, Li Y, Zhang X, Xu Z, Zhou J, Shang W

Drug Design, Development and Therapy 2020, 14:3929-3940

Published Date: 25 September 2020

Antiemetic Prophylaxis with Fosaprepitant and 5-HT3-Receptor Antagonists in Pediatric Patients Undergoing Autologous Hematopoietic Stem Cell Transplantation

Cabanillas Stanchi KM, Willier S, Vek J, Schlegel P, Queudeville M, Rieflin N, Klaus V, Gansel M, Rupprecht JV, Flaadt T, Binder V, Feuchtinger T, Lang P, Handgretinger R, Döring M

Drug Design, Development and Therapy 2020, 14:3915-3927

Published Date: 25 September 2020

Phoenixin 14 Inhibits High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Experimental Mice

Yang F, Huang P, Shi L, Liu F, Tang A, Xu S

Drug Design, Development and Therapy 2020, 14:3865-3874

Published Date: 22 September 2020

Protective Effect of Pravastatin on Myocardial Ischemia Reperfusion Injury by Regulation of the miR-93/Nrf2/ARE Signal Pathway

Liu Z, Zhang F, Zhao L, Zhang X, Li Y, Liu L

Drug Design, Development and Therapy 2020, 14:3853-3864

Published Date: 22 September 2020

Synergistic Cytotoxic Effect from Combination of Wedelolactone and Cisplatin in HeLa Cell Line: A Novel Finding

Sarwar S, Yu JQ, Nadeem H, Huq F

Drug Design, Development and Therapy 2020, 14:3841-3852

Published Date: 22 September 2020

Bacterial Natural Compounds with Anti-Inflammatory and Immunomodulatory Properties (Mini Review)

Jenab A, Roghanian R, Emtiazi G

Drug Design, Development and Therapy 2020, 14:3787-3801

Published Date: 18 September 2020

Effect of 4-Fluoro-N-(4-Sulfamoylbenzyl) Benzene Sulfonamide on Acquisition and Expression of Nicotine-Induced Behavioral Sensitization and Striatal Adenosine Levels

Ur Rehman N, Abbas M, al-Rashida M, Tokhi A, Arshid MA, Khan MS, Ahmad I, Rauf K

Drug Design, Development and Therapy 2020, 14:3777-3786

Published Date: 17 September 2020

Exosomes Derived from Mesenchymal Stem Cells Protect the Myocardium Against Ischemia/Reperfusion Injury Through Inhibiting Pyroptosis

Tang J, Jin L, Liu Y, Li L, Ma Y, Lu L, Ma J, Ding P, Yang X, Liu J, Yang J

Drug Design, Development and Therapy 2020, 14:3765-3775

Published Date: 16 September 2020

The Potential Effects of Aliskiren on Atrial Remodeling Induced by Chronic Intermittent Hypoxia in Rats

Miao S, Yang Y, Li R, Yin L, Zhang K, Cheng L, Xu X, Wang W, Zhao Z, Li G

Drug Design, Development and Therapy 2020, 14:3755-3764

Published Date: 16 September 2020

Astragaloside IV: An Effective Drug for the Treatment of Cardiovascular Diseases

Tan YQ, Chen HW, Li J

Drug Design, Development and Therapy 2020, 14:3731-3746

Published Date: 15 September 2020

Synthesis and Bioactivity of N-(4-Chlorophenyl)-4-Methoxy-3-(Methylamino) Benzamide as a Potential Anti-HBV Agent

Cui AL, Sun WF, Zhong ZJ, Jin J, Xue ST, Wu S, Li YH, Li ZR

Drug Design, Development and Therapy 2020, 14:3723-3729

Published Date: 15 September 2020

LncRNA SNHG4 Attenuates Inflammatory Responses by Sponging miR-449c-5p and Up-Regulating STAT6 in Microglial During Cerebral Ischemia-Reperfusion Injury

Zhang S, Sun W, Liang Z, Yin X, Ji Z, Chen X, Wei M, Pei L

Drug Design, Development and Therapy 2020, 14:3683-3695

Published Date: 11 September 2020

Emodin Reverses the Epithelial–Mesenchymal Transition of Human Endometrial Stromal Cells by Inhibiting ILK/GSK-3β Pathway

Zheng Q, Wang J, Li W, Chen X, Chen S, Chen L

Drug Design, Development and Therapy 2020, 14:3663-3672

Published Date: 10 September 2020

Knockdown of lncRNA HOXA-AS3 Suppresses the Progression of Atherosclerosis via Sponging miR-455-5p

Chi K, Zhang J, Sun H, Liu Y, Li Y, Yuan T, Zhang F

Drug Design, Development and Therapy 2020, 14:3651-3662

Published Date: 9 September 2020

Research Status and Outlook of PD-1/PD-L1 Inhibitors for Cancer Therapy

Ai L, Chen J, Yan H, He Q, Luo P, Xu Z, Yang X

Drug Design, Development and Therapy 2020, 14:3625-3649

Published Date: 8 September 2020

Enhancing the Butyrylcholinesterase Activity in HEK-293 Cell Line by Dual-Promoter Vector Decorated on Lipofectamine

Mirzaie V, Eslaminejad T, Babaei H, Nematollahi-Mahani SN

Drug Design, Development and Therapy 2020, 14:3589-3599

Published Date: 4 September 2020

Pinocembrin Ameliorates Cognitive Impairment Induced by Vascular Dementia: Contribution of Reelin-dab1 Signaling Pathway

Kang ZC, Wang HG, Yang YL, Zhao XY, Zhou QM, Yang YL, Yang JY, Du GH

Drug Design, Development and Therapy 2020, 14:3577-3587

Published Date: 4 September 2020

Emodin Retarded Renal Fibrosis Through Regulating HGF and TGFβ–Smad Signaling Pathway

Yang F, Deng L, Li J, Chen M, Liu Y, Hu Y, Zhong W

Drug Design, Development and Therapy 2020, 14:3567-3575

Published Date: 3 September 2020

Ketamine Enhances Intranasal Dexmedetomidine-Induced Sedation in Children: A Randomized, Double-Blind Trial

Qian B, Zheng W, Shi J, Chen Z, Guo Y, Yao Y

Drug Design, Development and Therapy 2020, 14:3559-3565

Published Date: 26 August 2020

LncRNA PVT1 Suppresses the Progression of Renal Fibrosis via Inactivation of TGF-β Signaling Pathway

Cao L, Qin P, Zhang J, Qiao H, Shi P, Huo H

Drug Design, Development and Therapy 2020, 14:3547-3557

Published Date: 26 August 2020

Fatostatin in Combination with Tamoxifen Induces Synergistic Inhibition in ER-Positive Breast Cancer

Liu Y, Zhang N, Zhang H, Wang L, Duan Y, Wang X, Chen T, Liang Y, Li Y, Song X, Li C, Han D, Chen B, Zhao W, Yang Q

Drug Design, Development and Therapy 2020, 14:3535-3545

Published Date: 26 August 2020

Bone-Targeting Liposome-Encapsulated Salvianic Acid A Improves Nonunion Healing Through the Regulation of HDAC3-Mediated Endochondral Ossification

Zhou L, Wu H, Gao X, Zheng X, Chen H, Li H, Peng J, Liang W, Wang W, Qiu Z, Udduttula A, Wu K, Li L, Liu Y, Liu Y

Drug Design, Development and Therapy 2020, 14:3519-3533

Published Date: 26 August 2020

Application of Intravenous Lidocaine in Obese Patients Undergoing Painless Colonoscopy: A Prospective, Randomized, Double-Blind, Controlled Study

Li X, Lv X, Jiang Z, Nie X, Wang X, Li T, Zhang L, Liu S

Drug Design, Development and Therapy 2020, 14:3509-3518

Published Date: 27 August 2020

Exosomes-Coated miR-34a Displays Potent Antitumor Activity in Pancreatic Cancer Both in vitro and in vivo

Zuo L, Tao H, Xu H, Li C, Qiao G, Guo M, Cao S, Liu M, Lin X

Drug Design, Development and Therapy 2020, 14:3495-3507

Published Date: 25 August 2020

Video Education Reduces Pain and Anxiety Levels in Cancer Patients Who First Use Fentanyl Transdermal Patch: A Randomized Controlled Trial

Ye Z, Chen J, Zhang Y, Hu X, Xuan Z, Yang S, Mao X, Rao Y

Drug Design, Development and Therapy 2020, 14:3477-3483

Published Date: 25 August 2020

Analysis of the Doxorubicin and Doxorubicinol in the Plasma of Breast Cancer Patients for Monitoring the Toxicity of Doxorubicin

Harahap Y, Ardiningsih P, Corintias Winarti A, Purwanto DJ

Drug Design, Development and Therapy 2020, 14:3469-3475

Published Date: 25 August 2020

Transarterial Chemoembolization Combined with Sorafenib in Patients with BCLC Stage C Hepatocellular Carcinoma

Liu KC, Hao YH, Lv WF, Jia WD, Ji CS, Zhou CZ, Cheng DL, Xu SB, Gao ZG, Su MX, Shi CS

Drug Design, Development and Therapy 2020, 14:3461-3468

Published Date: 25 August 2020

Levonorgestrel Ameliorates Adenomyosis via lncRNA H19/miR-17/TLR4 Pathway

Liang N, Zhang W, Wang H, Shi W, Wang L, Ma L

Drug Design, Development and Therapy 2020, 14:3449-3460

Published Date: 24 August 2020

Sarsasapogenin Suppresses RANKL-Induced Osteoclastogenesis in vitro and Prevents Lipopolysaccharide-Induced Bone Loss in vivo

Peng J, Zhao K, Zhu J, Wang Y, Sun P, Yang Q, Zhang T, Han W, Hu W, Yang W, Ruan J, Qian Y

Drug Design, Development and Therapy 2020, 14:3435-3447

Published Date: 24 August 2020

Efficacy of Sub-Tenon Micro-Perfusion of Cyclophosphamide in Rabbits with Severe Ocular Inflammation

Zhao L, Peng M, Lin W, Tan Q, Khan MA, Lin D

Drug Design, Development and Therapy 2020, 14:3407-3416

Published Date: 20 August 2020

Galangin Improved Non-Alcoholic Fatty Liver Disease in Mice by Promoting Autophagy

Zhang X, Deng Y, Xiang J, Liu H, Zhang J, Liao J, Chen K, Liu B, Liu J, Pu Y

Drug Design, Development and Therapy 2020, 14:3393-3405

Published Date: 19 August 2020

Cinnamaldehyde Treatment of Prostate Cancer-Associated Fibroblasts Prevents Their Inhibitory Effect on T Cells Through Toll-Like Receptor 4

Mei J, Ma J, Xu Y, Wang Y, Hu M, Ma F, Qin Z, Xue R, Tao N

Drug Design, Development and Therapy 2020, 14:3363-3372

Published Date: 18 August 2020

Cannabis Extract CT-921 Has a High Efficacy–Adverse Effect Profile in a Neuropathic Pain Model

Rouhollahi E, MacLeod BA, Barr AM, Puil E

Drug Design, Development and Therapy 2020, 14:3351-3361

Published Date: 17 August 2020

New Benzofuran N-Acylhydrazone Reduces Cardiovascular Dysfunction in Obese Rats by Blocking TNF-Alpha Synthesis

Costa GC, Montagnoli TL, Da Silva JS, Alencar AKN, Reina Gamba LE, Alves BEO, Silva MMC, Trachez MM, Nascimento JHM, Pimentel-Coelho PM, Mendez-Otero R, Lima LM, Barreiro EJ, Sudo RT, Zapata-Sudo G

Drug Design, Development and Therapy 2020, 14:3337-3350

Published Date: 17 August 2020

Beneficial Effect of Genistein on Diabetes-Induced Brain Damage in the ob/ob Mouse Model

Li R, Ding XW, Geetha T, Al-Nakkash L, Broderick TL, Babu JR

Drug Design, Development and Therapy 2020, 14:3325-3336

Published Date: 17 August 2020

Assessment of a New Ginsenoside Rh2 Nanoniosomal Formulation for Enhanced Antitumor Efficacy on Prostate Cancer: An in vitro Study

Zare-Zardini H, Alemi A, Taheri-Kafrani A, Hosseini SA, Soltaninejad H, Hamidieh AA, Haghi Karamallah M, Farrokhifar M, Farrokhifar M

Drug Design, Development and Therapy 2020, 14:3315-3324

Published Date: 13 August 2020

Dual Targeting of Cell Growth and Phagocytosis by Erianin for Human Colorectal Cancer

Sun Y, Li G, Zhou Q, Shao D, Lv J, Zhou J

Drug Design, Development and Therapy 2020, 14:3301-3313

Published Date: 12 August 2020

Therapeutic Drug Monitoring of Rivastigmine and Donepezil Under Consideration of CYP2D6 Genotype-Dependent Metabolism of Donepezil

Ortner M, Stange M, Schneider H, Schröder C, Buerger K, Müller C, Müller-Sarnowski F, Diehl-Schmid J, Förstl H, Grimmer T, Steimer W

Drug Design, Development and Therapy 2020, 14:3251-3262

Published Date: 11 August 2020

Potential Impact of the Multi-Target Drug Approach in the Treatment of Some Complex Diseases

Makhoba XH, Viegas Jr C, Mosa RA, Viegas FPD, Pooe OJ

Drug Design, Development and Therapy 2020, 14:3235-3249

Published Date: 11 August 2020

A Review on Remdesivir: A Possible Promising Agent for the Treatment of COVID-19

Hashemian SM, Farhadi T, Velayati AA

Drug Design, Development and Therapy 2020, 14:3215-3222

Published Date: 6 August 2020

Suppression of c-Met-Overexpressing Tumors by a Novel c-Met/CD3 Bispecific Antibody

Huang L, Xie K, Li H, Wang R, Xu X, Chen K, Gu H, Fang J

Drug Design, Development and Therapy 2020, 14:3201-3214

Published Date: 7 August 2020

Curcumin Protects Against Radiotherapy-Induced Oxidative Injury to the Skin

Shabeeb D, Musa AE, Abd Ali HS, Najafi M

Drug Design, Development and Therapy 2020, 14:3159-3163

Published Date: 5 August 2020

Bioequivalence Study of Amitriptyline Hydrochloride Tablets in Healthy Chinese Volunteers Under Fasting and Fed Conditions

Zhai Y, Wu L, Zheng Y, Wu M, Huang Y, Huang Q, Shentu J, Zhao Q, Liu J

Drug Design, Development and Therapy 2020, 14:3131-3142

Published Date: 4 August 2020

The PPARγ Agonist Rosiglitazone Enhances the Radiosensitivity of Human Pancreatic Cancer Cells

Wang Z, Shen W, Li X, Feng Y, Qian K, Wang G, Gao Y, Xu X, Zhang S, Yue L, Cao J

Drug Design, Development and Therapy 2020, 14:3099-3110

Published Date: 31 July 2020

Nano-Graphene Oxide-supported APTES-Spermine, as Gene Delivery System, for Transfection of pEGFP-p53 into Breast Cancer Cell Lines

Mirzaie V, Ansari M, Nematollahi-Mahani SN, Moballegh Nasery M, Karimi B, Eslaminejad T, Pourshojaei Y

Drug Design, Development and Therapy 2020, 14:3087-3097

Published Date: 30 July 2020

The Climate is Changing for Metered-Dose Inhalers and Action is Needed

Pritchard JN

Drug Design, Development and Therapy 2020, 14:3043-3055

Published Date: 29 July 2020

Chrysin Attenuates the NLRP3 Inflammasome Cascade to Reduce Synovitis and Pain in KOA Rats

Liao T, Ding L, Wu P, Zhang L, Li X, Xu B, Zhang H, Ma Z, Xiao Y, Wang P

Drug Design, Development and Therapy 2020, 14:3015-3027

Published Date: 28 July 2020

Antiviral Agent Therapy Optimization in Special Populations of COVID-19 Patients

Li L, Wang X, Wang R, Hu Y, Jiang S, Lu X

Drug Design, Development and Therapy 2020, 14:3001-3013

Published Date: 28 July 2020

Cordycepin Inhibits Human Gestational Choriocarcinoma Cell Growth by Disrupting Centrosome Homeostasis

Wang CY, Tsai SW, Chien HH, Chen TY, Sheu SY, So EC, Huang BM

Drug Design, Development and Therapy 2020, 14:2987-3000

Published Date: 27 July 2020

Soluplus-Mediated Diosgenin Amorphous Solid Dispersion with High Solubility and High Stability: Development, Characterization and Oral Bioavailability

Liu P, Zhou J, Chang J, Liu X, Xue H, Wang R, Li Z, Li C, Wang J, Liu C

Drug Design, Development and Therapy 2020, 14:2959-2975

Published Date: 27 July 2020

Enhancement of Antitumor Efficacy of Paclitaxel-Loaded PEGylated Liposomes by N,N-Dimethyl Tertiary Amino Moiety in Pancreatic Cancer

Chen Y, Wang L, Luo S, Hu J, Huang X, Li PW, Zhang Y, Wu C, Tian BL

Drug Design, Development and Therapy 2020, 14:2945-2957

Published Date: 23 July 2020

The Effects of Dexmedetomidine and Ketamine on Oxidative Injuries and Histological Changes Following Blunt Chest Trauma

Kartal S, Kip G, Küçük A, Aşçı SS, Erdem Ö, Arslan M, Kavutçu M

Drug Design, Development and Therapy 2020, 14:2937-2943

Published Date: 23 July 2020

Triptolide Inhibits the Proliferation of HaCaT Cells Induced by IL22 via Upregulating miR-181b-5p

He Q, Zhang B, Hu F, Long J, Shi Q, Pi X, Chen H, Li J

Drug Design, Development and Therapy 2020, 14:2927-2935

Published Date: 22 July 2020

Film-Forming Sprays for Topical Drug Delivery

Umar AK, Butarbutar M, Sriwidodo S, Wathoni N

Drug Design, Development and Therapy 2020, 14:2909-2925

Published Date: 22 July 2020

The Anti-Inflammatory Effect of Different Doses of Aliskiren in Rat Models of Inflammation

Aziz TA, Kareem AA, Othman HH, Ahmed ZA

Drug Design, Development and Therapy 2020, 14:2841-2851

Published Date: 20 July 2020

Lentinan Inhibits AGE-Induced Inflammation and the Expression of Matrix-Degrading Enzymes in Human Chondrocytes

Zhang Z, Zha Z, Zhao Z, Liu W, Li W

Drug Design, Development and Therapy 2020, 14:2819-2829

Published Date: 17 July 2020

Cordycepin Alleviates Anterior Cruciate Ligament Transection (ACLT)-Induced Knee Osteoarthritis Through Regulating TGF-β Activity and Autophagy

Tao XM, Liu PF, Gu HY, Lian DB, Gao L, Tao WW, Yan D, Zhao B

Drug Design, Development and Therapy 2020, 14:2809-2817

Published Date: 17 July 2020

A Synthetic Peptide 2Abz23S29 Reduces Bacterial Titer and Induces Pro-Inflammatory Cytokines in a Murine Model of Urinary Tract Infection

Moazzezy N, Asadi Karam MR, Rafati S, Bouzari S, Oloomi M

Drug Design, Development and Therapy 2020, 14:2797-2807

Published Date: 17 July 2020

Promising Swellable Floating Bupropion Tablets: Formulation, in vitro/in vivo Evaluation and Comparative Pharmacokinetic Study in Human Volunteers

Teaima M, Abdel Hamid MM, Shoman NA, Jasti BR, El-Nabarawi MA

Drug Design, Development and Therapy 2020, 14:2741-2757

Published Date: 14 July 2020

Network Pharmacology-Based Prediction and Verification of the Active Ingredients and Potential Targets of Zuojinwan for Treating Colorectal Cancer

Huang S, Zhang Z, Li W, Kong F, Yi P, Huang J, Mao D, Peng W, Zhang S

Drug Design, Development and Therapy 2020, 14:2725-2740

Published Date: 14 July 2020

The Regulating Mechanism of Chrysophanol on Protein Level of CaM-CaMKIV to Protect PC12 Cells Against Aβ25-35-Induced Damage

Ye T, Gao HW, Xuan WT, Ye S, Zhou P, Li XQ, Wang Y, Song H, Liu YY, Cai B

Drug Design, Development and Therapy 2020, 14:2715-2723

Published Date: 13 July 2020

Ribbon Synapses and Hearing Impairment in Mice After in utero Sevoflurane Exposure

Yuan X, Liu H, Li Y, Li W, Yu H, Shen X

Drug Design, Development and Therapy 2020, 14:2685-2693

Published Date: 8 July 2020

Anti-Breast Cancer Effect of 2-Dodecyl-6-Methoxycyclohexa-2,5-Diene-1,4-Dione in vivo and in vitro Through MAPK Signaling Pathway

Zhou X, Wu X, Qin L, Lu S, Zhang H, Wei J, Chen L, Jiang L, Wu Y, Chen C, Huang R

Drug Design, Development and Therapy 2020, 14:2667-2684

Published Date: 7 July 2020

N-Acetyl-l-Leucine-Polyethyleneimine-Mediated Delivery of CpG Oligodeoxynucleotides 2006 Inhibits RAW264.7 Cell Osteoclastogenesis

Wang H, Yu W, Li H, Zheng Y, Chen Z, Lin H, Shen Y

Drug Design, Development and Therapy 2020, 14:2657-2665

Published Date: 7 July 2020

Evaluation of Bioequivalency and Pharmacokinetic Parameters for Two Formulations of Glimepiride 1-mg in Chinese Subjects

Ju G, Yan K, Xu Y, Chen S, Zheng Z, Qiu W

Drug Design, Development and Therapy 2020, 14:2637-2644

Published Date: 6 July 2020

The Expression and Therapeutic Potential of Checkpoint Kinase 2 in Laryngeal Squamous Cell Carcinoma

Tian Y, Wang Y, Xu S, Guan C, Zhang Q, Li W

Drug Design, Development and Therapy 2020, 14:2613-2622

Published Date: 6 July 2020

Structural Insight into the Mechanism of 4-Aminoquinolines Selectivity for the alpha2A-Adrenoceptor

Li Z, Li J, Liu L, Deng W, Liu Q, Liu R, Zhang W, He Z, Fan L, Yang Y, Duan Y, Hou H, Wang X, Yang Z, Wang X, Chen S, Wang Y, Huang N, Chen J

Drug Design, Development and Therapy 2020, 14:2585-2594

Published Date: 3 July 2020

Melatonin Alleviates Neuronal Damage After Intracerebral Hemorrhage in Hyperglycemic Rats

Liang F, Wang J, Zhu X, Wang Z, Zheng J, Sun Z, Xu S, Zhang J, Zhou J, Shi L

Drug Design, Development and Therapy 2020, 14:2573-2584

Published Date: 2 July 2020

Effects of Calcium and Annatto Tocotrienol Supplementation on Bone Loss Induced by Pantoprazole in Male Rats

Chin KY, Thong BKS, Kamalulloh RF, Mohamad NV, Wong SK, Mohd Arlamsyah A, Triliana R, Soelaiman IN

Drug Design, Development and Therapy 2020, 14:2561-2572

Published Date: 2 July 2020

Impact of Administration Time and Kv7 Subchannels on the Cardioprotective Efficacy of Kv7 Channel Inhibition

Hansen J, Johnsen J, Nielsen JM, Sørensen CB, Elkjær CC, Jespersen NR, Bøtker HE

Drug Design, Development and Therapy 2020, 14:2549-2560

Published Date: 2 July 2020

Synthesis and Biological Evaluations of Monocarbonyl Curcumin Inspired Pyrazole Analogues as Potential Anti-Colon Cancer Agent

Min Z, Zhu Y, Hong X, Yu Z, Ye M, Yuan Q, Hu X

Drug Design, Development and Therapy 2020, 14:2517-2534

Published Date: 29 June 2020

Management of Pediatric Systemic Lupus Erythematosus: Focus on Belimumab

Guzman M, Hui-Yuen JS

Drug Design, Development and Therapy 2020, 14:2503-2513

Published Date: 25 June 2020

Remogliflozin Etabonate in the Treatment of Type 2 Diabetes: Design, Development, and Place in Therapy

Mohan V, Mithal A, Joshi SR, Aravind SR, Chowdhury S

Drug Design, Development and Therapy 2020, 14:2487-2501

Published Date: 24 June 2020

Are Laboratory Parameter (Biomarker) Values Similar to the Healthy Volunteer Reference Range in Individuals with Diabetes

Brott DA, Goodman MJ, Hermann RP, Anderson I, Kiazand A

Drug Design, Development and Therapy 2020, 14:2473-2486

Published Date: 24 June 2020

Berberine Attenuates Arterial Plaque Formation in Atherosclerotic Rats with Damp-Heat Syndrome via Regulating Autophagy

Ke X, Huang Y, Li L, Xin F, Xu L, Zhang Y, Zeng Z, Lin F, Song Y

Drug Design, Development and Therapy 2020, 14:2449-2460

Published Date: 23 June 2020

Artificial Neural Network (ANN) Approach to Predict an Optimized pH-Dependent Mesalamine Matrix Tablet

Khan AM, Hanif M, Bukhari NI, Shamim R, Rasool F, Rasul S, Shafique S

Drug Design, Development and Therapy 2020, 14:2435-2448

Published Date: 22 June 2020

Aprepitant Sensitizes Acute Myeloid Leukemia Cells to the Cytotoxic Effects of Cytosine Arabinoside in vitro and in vivo

Wu H, Cheng X, Huang F, Shao G, Meng Y, Wang L, Wang T, Jia X, Yang T, Wang X, Fu C

Drug Design, Development and Therapy 2020, 14:2413-2422

Published Date: 18 June 2020

Sugar Codes Conjugated Alginate: An Innovative Platform to Make a Strategic Breakthrough in Simultaneous Prophylaxis of GERD and Helicobacter pylori Infection

Moayedi S, Yadegar A, Balalaie S, Yarmohammadi M, Zali MR, Suzuki H, Fricker G, Haririan I

Drug Design, Development and Therapy 2020, 14:2405-2412

Published Date: 17 June 2020

Metformin Decreases Insulin Resistance in Type 1 Diabetes Through Regulating p53 and RAP2A in vitro and in vivo

Ren GF, Xiao LL, Ma XJ, Yan YS, Jiao PF

Drug Design, Development and Therapy 2020, 14:2381-2392

Published Date: 17 June 2020

Activation of GPR40 Suppresses AGE-Induced Reduction of Type II Collagen and Aggrecan in Human SW1353 Chondrocytes

Gu J, Lin H, Zhang Y, Xu T, Wang T, Xue X, Zhang W, Liu H

Drug Design, Development and Therapy 2020, 14:2371-2379

Published Date: 15 June 2020

A Gastric Cancer Peptide GX1-Modified Nano-Lipid Carriers Encapsulating Paclitaxel: Design and Evaluation of Anti-Tumor Activity

Jian Y, Zhao M, Cao J, Fan T, Bu W, Yang Y, Li W, Zhang W, Qiao Y, Wang J, Wen A

Drug Design, Development and Therapy 2020, 14:2355-2370

Published Date: 12 June 2020

In vitro and in vivo Anti-Tumor Effects of Pan-HER Inhibitor Varlitinib on Cholangiocarcinoma Cell Lines

Dokduang H, Jamnongkarn W, Promraksa B, Suksawat M, Padthaisong S, Thanee M, Phetcharaburanin J, Namwat N, Sangkhamanon S, Titapun A, Khuntikeo N, Klanrit P, Loilome W

Drug Design, Development and Therapy 2020, 14:2319-2334

Published Date: 11 June 2020

Scalable in silico Simulation of Transdermal Drug Permeability: Application of BIOiSIM Platform

Maharao N, Antontsev V, Hou H, Walsh J, Varshney J

Drug Design, Development and Therapy 2020, 14:2307-2317

Published Date: 11 June 2020

Nimodipine Improves Cognitive Impairment After Subarachnoid Hemorrhage in Rats Through IncRNA NEAT1/miR-27a/MAPT Axis

Li JW, Ren SH, Ren JR, Zhen ZG, Li LR, Hao XD, Ji HM

Drug Design, Development and Therapy 2020, 14:2295-2306

Published Date: 10 June 2020

Combination Therapy of Lung Cancer Using Layer-by-Layer Cisplatin Prodrug and Curcumin Co-Encapsulated Nanomedicine

Hong Y, Che S, Hui B, Wang X, Zhang X, Ma H

Drug Design, Development and Therapy 2020, 14:2263-2274

Published Date: 9 June 2020

Combination Chemotherapy of Lung Cancer – Co-Delivery of Docetaxel Prodrug and Cisplatin Using Aptamer-Decorated Lipid–Polymer Hybrid Nanoparticles

Wu R, Zhang Z, Wang B, Chen G, Zhang Y, Deng H, Tang Z, Mao J, Wang L

Drug Design, Development and Therapy 2020, 14:2249-2261

Published Date: 9 June 2020

Parenteral Sustained Release Lipid Phase-Transition System of Ziprasidone: Fabrication and Evaluation for Schizophrenia Therapy

Khan UA, Parveen U, Hasan N, Ahmed MZ, Saad S, Ahmad FJ, Jain GK

Drug Design, Development and Therapy 2020, 14:2237-2247

Published Date: 9 June 2020

Treatment with a PPAR-γ Agonist Protects Against Hyperuricemic Nephropathy in a Rat Model

Wang X, Deng J, Xiong C, Chen H, Zhou Q, Xia Y, Shao X, Zou H

Drug Design, Development and Therapy 2020, 14:2221-2233

Published Date: 8 June 2020

Gastro-Protective Effects of Calycosin Against Precancerous Lesions of Gastric Carcinoma in Rats

Li D, Zhao L, Li Y, Kang X, Zhang S

Drug Design, Development and Therapy 2020, 14:2207-2219

Published Date: 9 June 2020

Effects of Voriconazole on the Pharmacokinetics of Vonoprazan in Rats

Shen J, Wang B, Wang S, Chen F, Meng D, Jiang H, Zhou Y, Geng P, Zhou Q, Liu B

Drug Design, Development and Therapy 2020, 14:2199-2206

Published Date: 4 June 2020

Development of 13-Cys-BBR as an Agent Having Dual Action of Anti-Thrombosis and Anti-Inflammation

Li G, Wang T, Zhang X, Zhao S, Wang Y, Wu J, Peng S, Zhao M

Drug Design, Development and Therapy 2020, 14:2187-2197

Published Date: 3 June 2020

Comparative Cholinesterase, α-Glucosidase Inhibitory, Antioxidant, Molecular Docking, and Kinetic Studies on Potent Succinimide Derivatives

Ahmad A, Ullah F, Sadiq A, Ayaz M, Saeed Jan M, Shahid M, Wadood A, Mahmood F, Rashid U, Ullah R, Sahibzada MUK, Alqahtani AS, Mahmood HM

Drug Design, Development and Therapy 2020, 14:2165-2178

Published Date: 3 June 2020

Analysis of Renal and Cardiac Outcomes in Male Participants in the Fabry Outcome Survey Starting Agalsidase Alfa Enzyme Replacement Therapy Before and After 18 Years of Age

Parini R, Pintos-Morell G, Hennermann JB, Hsu TR, Karabul N, Kalampoki V, Gurevich A, Ramaswami U

Drug Design, Development and Therapy 2020, 14:2149-2158

Published Date: 3 June 2020

Network Pharmacology and Experimental Evidence Reveal Dioscin Suppresses Proliferation, Invasion, and EMT via AKT/GSK3b/mTOR Signaling in Lung Adenocarcinoma

Mao W, Yin H, Chen W, Zhao T, Wu S, Jin H, Du B, Tan Y, Zhang R, He Y

Drug Design, Development and Therapy 2020, 14:2135-2147

Published Date: 28 May 2020

Effect of Lactoferrin Protein on Red Blood Cells and Macrophages: Mechanism of Parasite–Host Interaction [Corrigendum]

Anand N, Kanwar R, Dubey M, Vahishta RK, Sehgal R, Verma A, Kanwar J

Drug Design, Development and Therapy 2020, 14:2123-2124

Published Date: 28 May 2020

A Pharmacokinetic Drug Interaction Between Fimasartan and Linagliptin in Healthy Volunteers

Kang WY, Lee HW, Gwon MR, Cho S, Shim WS, Lee KT, Yang DH, Seong SJ, Yoon YR

Drug Design, Development and Therapy 2020, 14:2101-2111

Published Date: 26 May 2020

Dihydroartemisinin Inhibits the Proliferation of Leukemia Cells K562 by Suppressing PKM2 and GLUT1 Mediated Aerobic Glycolysis

Gao P, Shen S, Li X, Liu D, Meng Y, Liu Y, Zhu Y, Zhang J, Luo P, Gu L

Drug Design, Development and Therapy 2020, 14:2091-2100

Published Date: 27 May 2020

Resveratrol Exerts Anti-Osteoarthritic Effect by Inhibiting TLR4/NF-κB Signaling Pathway via the TLR4/Akt/FoxO1 Axis in IL-1β-Stimulated SW1353 Cells

Xu X, Liu X, Yang Y, He J, Jiang M, Huang Y, Liu X, Liu L, Gu H

Drug Design, Development and Therapy 2020, 14:2079-2090

Published Date: 26 May 2020

Synthesis and Biological Activity of Piperine Derivatives as Potential PPARγ Agonists

Wang Y, Yao Y, Liu J, Wu L, Liu T, Cui J, Lee DYW

Drug Design, Development and Therapy 2020, 14:2069-2078

Published Date: 26 May 2020

Glycine Improves Ischemic Stroke Through miR-19a-3p/AMPK/GSK-3β/HO-1 Pathway

Chen ZJ, Zhao XS, Fan TP, Qi HX, Li D

Drug Design, Development and Therapy 2020, 14:2021-2031

Published Date: 25 May 2020

A Triple Combination of Metformin, Acetylsalicylic Acid, and Oseltamivir Phosphate Impacts Tumour Spheroid Viability and Upends Chemoresistance in Triple-Negative Breast Cancer

Sambi M, Samuel V, Qorri B, Haq S, Burov SV, Markvicheva E, Harless W, Szewczuk MR

Drug Design, Development and Therapy 2020, 14:1995-2019

Published Date: 25 May 2020

Effects of Apatinib on the Pharmacokinetics of Nifedipine and Warfarin in Patients with Advanced Solid Tumors

Zhu YT, Teng Z, Zhang YF, Li W, Guo LX, Liu YP, Qu XJ, Wang QR, Mao SY, Chen XY, Zhong DF

Drug Design, Development and Therapy 2020, 14:1963-1970

Published Date: 20 May 2020

Alleviation of Liver Dysfunction, Oxidative Stress and Inflammation Underlies the Protective Effect of Ferulic Acid in Methotrexate-Induced Hepatotoxicity

Roghani M, Kalantari H, Khodayar MJ, Khorsandi L, Kalantar M, Goudarzi M, Kalantar H

Drug Design, Development and Therapy 2020, 14:1933-1941

Published Date: 20 May 2020

Inhibitory Effect of Lygodium Root on the Cytochrome P450 3A Enzyme in vitro and in vivo

Zhou Y, Hua A, Zhou Q, Geng P, Chen F, Yan L, Wang S, Wen C

Drug Design, Development and Therapy 2020, 14:1909-1919

Published Date: 19 May 2020

Applying Different Techniques to Improve the Bioavailability of Candesartan Cilexetil Antihypertensive Drug

Aly UF, Sarhan HA, Ali TFS, Sharkawy HAEB

Drug Design, Development and Therapy 2020, 14:1851-1865

Published Date: 14 May 2020

Pharmacokinetics and Metabolism Research of Shenkang Injection in Rats Based on UHPLC-MS/MS and UHPLC-Q-Orbitrap HRMS

Jiang X, Zhou L, Zuo L, Wang X, Shi Y, Du X, Zhang J, Liu L, Li Z, Xue L, Liu X, Sun Z

Drug Design, Development and Therapy 2020, 14:1837-1850

Published Date: 13 May 2020

Berberine Induces Autophagic Cell Death in Acute Lymphoblastic Leukemia by Inactivating AKT/mTORC1 Signaling

Liu J, Liu P, Xu T, Chen Z, Kong H, Chu W, Wang Y, Liu Y

Drug Design, Development and Therapy 2020, 14:1813-1823

Published Date: 12 May 2020

Pranlukast Antagonizes CD49f and Reduces Stemness in Triple-Negative Breast Cancer Cells

Velázquez-Quesada I, Ruiz-Moreno AJ, Casique-Aguirre D, Aguirre-Alvarado C, Cortés-Mendoza F, de la Fuente-Granada M, García-Pérez C, Pérez-Tapia SM, González-Arenas A, Segura-Cabrera A, Velasco-Velázquez MA

Drug Design, Development and Therapy 2020, 14:1799-1811

Published Date: 12 May 2020

Virtual Screening and Optimization of Novel mTOR Inhibitors for Radiosensitization of Hepatocellular Carcinoma

Feng YQ, Gu SX, Chen YS, Gao XD, Ren YX, Chen JC, Lu YY, Zhang H, Cao S

Drug Design, Development and Therapy 2020, 14:1779-1798

Published Date: 8 May 2020

Investigation of the Inhibitory Effect of Simvastatin on the Metabolism of Lidocaine Both in vitro and in vivo

Wang Y, Ou-yang Q, Huang W, Huang H, Zhuang X, Lin Q, Zeng D

Drug Design, Development and Therapy 2020, 14:1739-1747

Published Date: 6 May 2020

Pharmacokinetic Evaluation by Modeling and Simulation Analysis of a Donepezil Patch Formulation in Healthy Male Volunteers

Yoon SK, Bae KS, Hong DH, Kim SS, Choi YK, Lim HS

Drug Design, Development and Therapy 2020, 14:1729-1737

Published Date: 5 May 2020

High ACTN1 Is Associated with Poor Prognosis, and ACTN1 Silencing Suppresses Cell Proliferation and Metastasis in Oral Squamous Cell Carcinoma

Xie G, Zhao L, Chen Q, Tang D, Chen Q, Lu H, Cai J, Chen Z

Drug Design, Development and Therapy 2020, 14:1717-1727

Published Date: 5 May 2020

Pexidartinib, a Novel Small Molecule CSF-1R Inhibitor in Use for Tenosynovial Giant Cell Tumor: A Systematic Review of Pre-Clinical and Clinical Development

Benner B, Good L, Quiroga D, Schultz TE, Kassem M, Carson WE, Cherian MA, Sardesai S, Wesolowski R

Drug Design, Development and Therapy 2020, 14:1693-1704

Published Date: 4 May 2020

Pharmacokinetic-Based Drug–Drug Interactions with Anaplastic Lymphoma Kinase Inhibitors: A Review

Zhao D, Chen J, Chu M, Long X, Wang J

Drug Design, Development and Therapy 2020, 14:1663-1681

Published Date: 30 April 2020

Astaxanthin Attenuates Neuroinflammation in Status Epilepticus Rats by Regulating the ATP-P2X7R Signal

Wang M, Deng X, Xie Y, Chen Y

Drug Design, Development and Therapy 2020, 14:1651-1662

Published Date: 30 April 2020

Arsenic Disulfide Promoted Hypomethylation by Increasing DNA Methyltransferases Expression in Myelodysplastic Syndrome

Zhou QB, Liu ZT, Wang HZ, Guo XQ, Xu YG, Hu XM

Drug Design, Development and Therapy 2020, 14:1641-1650

Published Date: 30 April 2020

Effect of Eriodictyol on Collagen-Induced Arthritis in Rats by Akt/HIF-1α Pathway

Lei Z, Ouyang L, Gong Y, Wang Z, Yu B

Drug Design, Development and Therapy 2020, 14:1633-1639

Published Date: 29 April 2020

Bone Marrow Mesenchymal Stem Cell-Derived Exosomes Improves Spinal Cord Function After Injury in Rats by Activating Autophagy

Gu J, Jin ZS, Wang CM, Yan XF, Mao YQ, Chen S

Drug Design, Development and Therapy 2020, 14:1621-1631

Published Date: 29 April 2020

In vitro Multistage Malaria Transmission Blocking Activity of Selected Malaria Box Compounds

Malebo HM, D'Alessandro S, Ebstie YA, Sorè H, Tenoh Guedoung AR, Katani SJ, Parapini S, Taramelli D, Habluetzel A

Drug Design, Development and Therapy 2020, 14:1593-1607

Published Date: 28 April 2020

Metformin Inhibits Propofol-Induced Apoptosis of Mouse Hippocampal Neurons HT-22 Through Downregulating Cav-1

Ge J, Huang Y, Zhang Y, Liu L, Gu T, Liu X, Yao L, Cai M, Sun J, Song J

Drug Design, Development and Therapy 2020, 14:1561-1569

Published Date: 21 April 2020

ACE2 Attenuates Epithelial-Mesenchymal Transition in MLE-12 Cells Induced by Silica

Li S, Li Y, Xu H, Wei Z, Yang Y, Jin F, Zhang M, Wang C, Song W, Huo J, Zhao J, Yang X, Yang F

Drug Design, Development and Therapy 2020, 14:1547-1559

Published Date: 21 April 2020

Selection and Characterization of a Novel DNA Aptamer, Apt-07S Specific to Hepatocellular Carcinoma Cells

Yu XX, Ge KL, Liu N, Zhang JY, Xue ML, Ge YL

Drug Design, Development and Therapy 2020, 14:1535-1545

Published Date: 20 April 2020

Optimal Approach and Strategies to Strengthen Pharmacovigilance in Sub-Saharan Africa: A Cohort Study of Patients Treated with First-Line Artemisinin-Based Combination Therapies in the Nanoro Health and Demographic Surveillance System, Burkina Faso

Rouamba T, Sondo P, Derra K, Nakanabo-Diallo S, Bihoun B, Rouamba E, Tarnagda Z, Kazienga A, Valea I, Sorgho H, Pagnoni F, Samadoulougou-Kirakoya F, Tinto H

Drug Design, Development and Therapy 2020, 14:1507-1521

Published Date: 16 April 2020

Isoliquiritigenin Attenuates UUO-Induced Renal Inflammation and Fibrosis by Inhibiting Mincle/Syk/NF-Kappa B Signaling Pathway

Liao Y, Tan R, Li J, Liu T, Zhong X, Yan Y, Yang J, Lin X, Fan J, Wang L

Drug Design, Development and Therapy 2020, 14:1455-1468

Published Date: 14 April 2020

Salidroside Alleviates Cartilage Degeneration Through NF-κB Pathway in Osteoarthritis Rats

Gao H, Peng L, Li C, Ji Q, Li P

Drug Design, Development and Therapy 2020, 14:1445-1454

Published Date: 14 April 2020

Metabolite Profiling in Anticancer Drug Development: A Systematic Review

Muhamad N, Na-Bangchang K

Drug Design, Development and Therapy 2020, 14:1401-1444

Published Date: 9 April 2020

One-Pot Synthesis of Novel Thiazoles as Potential Anti-Cancer Agents

Sayed AR, Gomha SM, Taher EA, Muhammad ZA, El-Seedi HR, Gaber HM, Ahmed MM

Drug Design, Development and Therapy 2020, 14:1363-1375

Published Date: 3 April 2020

Proniosomal Telmisartan Tablets: Formulation, in vitro Evaluation and in vivo Comparative Pharmacokinetic Study in Rabbits

Teaima MH, Yasser M, El-Nabarawi MA, Helal DA

Drug Design, Development and Therapy 2020, 14:1319-1331

Published Date: 31 March 2020

Leishmania donovani Growth Inhibitors from Pathogen Box Compounds of Medicine for Malaria Venture

Tadele M, Abay SM, Makonnen E, Hailu A

Drug Design, Development and Therapy 2020, 14:1307-1317

Published Date: 31 March 2020

Alginate Suppresses Liver Fibrosis Through the Inhibition of Nuclear Factor-κB Signaling

Xia Z, Ding L, Zheng J, Xu Y, Jin W, Sheng X, Wu J

Drug Design, Development and Therapy 2020, 14:1295-1305

Published Date: 31 March 2020

Diterpene Ginkgolides Exert an Antidepressant Effect Through the NT3-TrkA and Ras-MAPK Pathways

Wang T, Bai S, Wang W, Chen Z, Chen J, Liang Z, Qi X, Shen H, Xie P

Drug Design, Development and Therapy 2020, 14:1279-1294

Published Date: 31 March 2020

Growth Factor Gene-Modified Mesenchymal Stem Cells in Tissue Regeneration

Nie WB, Zhang D, Wang LS

Drug Design, Development and Therapy 2020, 14:1241-1256

Published Date: 26 March 2020

Morusin Ameliorates IL-1β-Induced Chondrocyte Inflammation and Osteoarthritis via NF-κB Signal Pathway

Jia Y, He W, Zhang H, He L, Wang Y, Zhang T, Peng J, Sun P, Qian Y

Drug Design, Development and Therapy 2020, 14:1227-1240

Published Date: 26 March 2020

Comparison of Pharmacokinetics of Aprepitant in Healthy Chinese and Caucasian Subjects

Yang MJ, Xu HR, Li H, Chen WL, Yuan F, Li XN

Drug Design, Development and Therapy 2020, 14:1219-1226

Published Date: 24 March 2020

Miconazole Contributes to NRF2 Activation by Noncanonical P62-KEAP1 Pathway in Bladder Cancer Cells

Tsai TF, Chen PC, Lin YC, Chou KY, Chen HE, Ho CY, Lin JF, Hwang TIS

Drug Design, Development and Therapy 2020, 14:1209-1218

Published Date: 24 March 2020

Paeoniflorin Ameliorates Chronic Hypoxia/SU5416-Induced Pulmonary Arterial Hypertension by Inhibiting Endothelial-to-Mesenchymal Transition

Yu M, Peng L, Liu P, Yang M, Zhou H, Ding Y, Wang J, Huang W, Tan Q, Wang Y, Xie W, Kong H, Wang H

Drug Design, Development and Therapy 2020, 14:1191-1202

Published Date: 19 March 2020

A First-in-Human Dose Finding Study of Camrelizumab in Patients with Advanced or Metastatic Cancer in Australia

Lickliter JD, Gan HK, Voskoboynik M, Arulananda S, Gao B, Nagrial A, Grimison P, Harrison M, Zou J, Zhang L, Luo S, Lahn M, Kallender H, Mannucci A, Somma C, Woods K, Behren A, Fernandez-Penas P, Millward M, Meniawy T

Drug Design, Development and Therapy 2020, 14:1177-1189

Published Date: 18 March 2020

Hyaluronic Acid Capped, Irinotecan and Gene Co-Loaded Lipid-Polymer Hybrid Nanocarrier-Based Combination Therapy Platform for Colorectal Cancer

Wang Z, Zang A, Wei Y, An L, Hong D, Shi Y, Zhang J, Su S, Fang G

Drug Design, Development and Therapy 2020, 14:1095-1105

Published Date: 12 March 2020

Review on the Structures and Activities of Transthyretin Amyloidogenesis Inhibitors

Guo X, Liu Z, Zheng Y, Li Y, Li L, Liu H, Chen Z, Wu L

Drug Design, Development and Therapy 2020, 14:1057-1081

Published Date: 10 March 2020

KLF6 Induces Apoptosis in Human Lens Epithelial Cells Through the ATF4-ATF3-CHOP Axis

Tian F, Zhao J, Bu S, Teng H, Yang J, Zhang X, Li X, Dong L

Drug Design, Development and Therapy 2020, 14:1041-1055

Published Date: 9 March 2020

In silico Design and Synthesis of Tetrahydropyrimidinones and Tetrahydropyrimidinethiones as Potential Thymidylate Kinase Inhibitors Exerting Anti-TB Activity Against Mycobacterium tuberculosis

Venugopala KN, Tratrat C, Pillay M, Chandrashekharappa S, Al-Attraqchi OHA, Aldhubiab BE, Attimarad M, Alwassil OI, Nair AB, Sreeharsha N, Venugopala R, Morsy MA, Haroun M, Kumalo HM, Odhav B, Mlisana K

Drug Design, Development and Therapy 2020, 14:1027-1039

Published Date: 9 March 2020

Characterization and Evaluation of Antioxidant Activity of Aloe schelpei Reynolds

Teka T, Kassahun H

Drug Design, Development and Therapy 2020, 14:1003-1008

Published Date: 5 March 2020

Bisdemethoxycurcumin Inhibits Hepatocellular Carcinoma Proliferation Through Akt Inactivation via CYLD-Mediated Deubiquitination

Qiu C, Liu K, Zhang S, Gao S, Chen W, Li D, Huang Y

Drug Design, Development and Therapy 2020, 14:993-1001

Published Date: 5 March 2020

Study on the Formation of Antihypertensive Twin Drugs by Caffeic Acid and Ferulic Acid with Telmisartan

Li P, Peng Y, Ma Q, Li Z, Zhang X

Drug Design, Development and Therapy 2020, 14:977-992

Published Date: 5 March 2020

Perindopril in Breast Milk and Determination of Breastfed Infant Exposure: A Prospective Observational Study

Leggett C, Lwin EMP, Ritchie U, Song Y, Gerber JP, Turner S, Hague WM, Stark M, Upton R, Garg S

Drug Design, Development and Therapy 2020, 14:961-967

Published Date: 2 March 2020

Finasteride and Its Potential for the Treatment of Female Pattern Hair Loss: Evidence to Date

Iamsumang W, Leerunyakul K, Suchonwanit P

Drug Design, Development and Therapy 2020, 14:951-959

Published Date: 2 March 2020

The Traditional Chinese Medicine Compound, GRS, Alleviates Blood–Brain Barrier Dysfunction

Zhang Y, Hu Y, Li M, Wang J, Guo G, Li F, Yu B, Kou J

Drug Design, Development and Therapy 2020, 14:933-947

Published Date: 28 February 2020

Oxymatrine Liposomes for Intervertebral Disc Treatment: Formulation, in vitro and vivo Assessments

Wang H, Ding Y, Zhang W, Wei K, Pei Y, Zou C, Zhang C, Ding J, Fang H, Tan S

Drug Design, Development and Therapy 2020, 14:921-931

Published Date: 28 February 2020

Pleiotropic Anticancer Properties of Scorpion Venom Peptides: Rhopalurus princeps Venom as an Anticancer Agent

Mikaelian AG, Traboulay E, Zhang XM, Yeritsyan E, Pedersen PL, Ko YH, Matalka KZ

Drug Design, Development and Therapy 2020, 14:881-893

Published Date: 27 February 2020

The Advantages of Levodopa-Carbidopa Intestinal Gel for Patients with Advanced Parkinson’s Disease: A Systematic Review

Zhang XR, Jiang ZY, Zhang ZR, Chen HJ, Wu K, He JC, Xie CL

Drug Design, Development and Therapy 2020, 14:845-854

Published Date: 26 February 2020

Metalloprotoporphyrin Inhibition of HCV NS3-4A Protease: Structure–Activity Relationships

Hu K, Zhu Z, Mathahs MM, Tran H, Bommer J, Testa CA, Schmidt WN

Drug Design, Development and Therapy 2020, 14:757-771

Published Date: 24 February 2020

NVP-BSK805, an Inhibitor of JAK2 Kinase, Significantly Enhances the Radiosensitivity of Esophageal Squamous Cell Carcinoma in vitro and in vivo

Hua Y, Wang W, Zheng X, Yang L, Wu H, Hu Z, Li Y, Yue J, Jiang Z, Zhang X, Hou Q, Wu S

Drug Design, Development and Therapy 2020, 14:745-755

Published Date: 24 February 2020

Synthesis, Characterization, and Pharmacodynamics Study of Enrofloxacin Mesylate

Pei L, Yang W, Fu J, Liu M, Zhang T, Li D, Huang R, Zhang L, Peng G, Shu G, Yuan Z, Lin J, Zhang W, Zhong Z, Zhao L, Fu H

Drug Design, Development and Therapy 2020, 14:715-730

Published Date: 24 February 2020

Anti-Inflammatory Activity of Sanjie Zhentong Capsule Assessed By Network Pharmacology Analysis of Adenomyosis Treatment 

Du L, Du DH, Chen B, Ding Y, Zhang T, Xiao W

Drug Design, Development and Therapy 2020, 14:697-713

Published Date: 20 February 2020

Colon Targeting of Naringin for Enhanced Cytoprotection Against Indomethacin-Induced Colitis in Rabbits

El Naggar EE, Mohamed EA, Borg TM, El-Sheakh AR, Hamed MF

Drug Design, Development and Therapy 2020, 14:677-696

Published Date: 19 February 2020

Impacts of CYP2C19 Polymorphism and Clopidogrel Dosing on in-Stent Restenosis: A Retrospective Cohort Study in Chinese Patients

Zhang M, Wang J, Zhang Y, Zhang P, Jia Z, Ren M, Jia X, Ma L, Gao M, Hou Y

Drug Design, Development and Therapy 2020, 14:669-676

Published Date: 19 February 2020

A Comparative Study of Inhaled Nitric Oxide and an Intravenously Administered Nitric Oxide Donor in Acute Pulmonary Hypertension

Stene Hurtsén A, Zorikhin Nilsson I, Dogan EM, Nilsson KF

Drug Design, Development and Therapy 2020, 14:635-645

Published Date: 17 February 2020

Hydrogen Sulfide Protects Against High Glucose-Induced Human Umbilical Vein Endothelial Cell Injury Through Activating PI3K/Akt/eNOS Pathway

Lin F, Yang Y, Wei S, Huang X, Peng Z, Ke X, Zeng Z, Song Y

Drug Design, Development and Therapy 2020, 14:621-633

Published Date: 14 February 2020

Pharmacokinetics and Tolerability of Single and Multiple Intravenous Doses of Cefotetan Disodium in Healthy Chinese Volunteers

Liu J, Zhai Y, Wu L, Wu G, Zheng Y, Hu X, Shentu J

Drug Design, Development and Therapy 2020, 14:613-620

Published Date: 13 February 2020

Silibinin Augments the Antifibrotic Effect of Valsartan Through Inactivation of TGF-β1 Signaling in Kidney

Liu R, Wang Q, Ding Z, Zhang X, Li Y, Zang Y, Zhang G

Drug Design, Development and Therapy 2020, 14:603-611

Published Date: 13 February 2020

Lysosomal Acid Lipase Deficiency: Therapeutic Options

Pastores GM, Hughes DA

Drug Design, Development and Therapy 2020, 14:591-601

Published Date: 11 February 2020

Regulations of miR-183-5p and Snail-Mediated Shikonin-Reduced Epithelial-Mesenchymal Transition in Cervical Cancer Cells

Tang Q, Liu L, Zhang H, Xiao J, Hann SS

Drug Design, Development and Therapy 2020, 14:577-589

Published Date: 11 February 2020

Minoxidil and Its Use in Hair Disorders: A Review [Corrigendum]

Suchonwanit P, Thammarucha S, Leerunyakul K

Drug Design, Development and Therapy 2020, 14:575-576

Published Date: 10 February 2020

Optimization of a Benzothiazole Indolene Scaffold Targeting Bacterial Cell Wall Assembly

Chauhan J, Yu W, Cardinale S, Opperman TJ, MacKerell AD Jr, Fletcher S, de Leeuw EPH

Drug Design, Development and Therapy 2020, 14:567-574

Published Date: 10 February 2020

Focus on Notoginsenoside R1 in Metabolism and Prevention Against Human Diseases

Liu H, Yang J, Yang W, Hu S, Wu Y, Zhao B, Hu H, Du S

Drug Design, Development and Therapy 2020, 14:551-565

Published Date: 7 February 2020

Potential Use of Microbial Surfactant in Microemulsion Drug Delivery System: A Systematic Review

Ohadi M, Shahravan A, Dehghannoudeh N, Eslaminejad T, Banat IM, Dehghannoudeh G

Drug Design, Development and Therapy 2020, 14:541-550

Published Date: 5 February 2020

In silico Analysis, Molecular Docking, Molecular Dynamic, Cloning, Expression and Purification of Chimeric Protein in Colorectal Cancer Treatment [Erratum]

Dana H, Mahmoodi Chalbatani G, Gharagouzloo E, Miri SR, Memari F, Rasoolzadeh R, Zinatizadeh MR, Kheirandish Zarandi P, Marmari V

Drug Design, Development and Therapy 2020, 14:539-540

Published Date: 5 February 2020

Panax Notoginseng Ameliorates Podocyte EMT by Targeting the Wnt/β-Catenin Signaling Pathway in STZ-Induced Diabetic Rats

Xie L, Zhai R, Chen T, Gao C, Xue R, Wang N, Wang J, Xu Y, Gui D

Drug Design, Development and Therapy 2020, 14:527-538

Published Date: 5 February 2020

Design, Synthesis and Biological Evaluation of New HDAC1 and HDAC2 Inhibitors Endowed with Ligustrazine as a Novel Cap Moiety

Al-Sanea MM, Gotina L, Mohamed MFA, Grace Thomas Parambi D, Gomaa HAM, Mathew B, Youssif BGM, Alharbi KS, Elsayed ZM, Abdelgawad MA, Eldehna WM

Drug Design, Development and Therapy 2020, 14:497-508

Published Date: 4 February 2020

New Isatin–Indole Conjugates: Synthesis, Characterization, and a Plausible Mechanism of Their in vitro Antiproliferative Activity

Al-Wabli RI, Almomen AA, Almutairi MS, Keeton AB, Piazza GA, Attia MI

Drug Design, Development and Therapy 2020, 14:483-495

Published Date: 3 February 2020

Metformin Activates the AMPK-mTOR Pathway by Modulating lncRNA TUG1 to Induce Autophagy and Inhibit Atherosclerosis

You G, Long X, Song F, Huang J, Tian M, Xiao Y, Deng S, Wu Q

Drug Design, Development and Therapy 2020, 14:457-468

Published Date: 3 February 2020

Development of a Novel Controlled-Release Tablet of Pregabalin: Formulation Variation and Pharmacokinetics in Dogs and Humans

Kim KH, Lim SH, Shim CR, Park J, Song WH, Kwon MC, Lee JH, Park JS, Choi HG

Drug Design, Development and Therapy 2020, 14:445-456

Published Date: 30 January 2020

Calycosin Influences the Metabolism of Five Probe Drugs in Rats

Wu M, Lin Y, Wei Y, Du H, Ying X, Tan W, Tang B

Drug Design, Development and Therapy 2020, 14:429-434

Published Date: 29 January 2020

A New Validated HPLC-MS/MS Method for Quantification and Pharmacokinetic Evaluation of Dovitinib, a Multi-Kinase Inhibitor, in Mouse Plasma

AlRabiah H, Kadi AA, Aljohar HI, Attwa MW, Al-Shakliah NS, Attia SM, Mostafa GAE

Drug Design, Development and Therapy 2020, 14:407-415

Published Date: 28 January 2020

Reversible Small Molecule Inhibitors of MAO A and MAO B with Anilide Motifs

Hagenow J, Hagenow S, Grau K, Khanfar M, Hefke L, Proschak E, Stark H

Drug Design, Development and Therapy 2020, 14:371-393

Published Date: 28 January 2020

In silico Analysis, Molecular Docking, Molecular Dynamic, Cloning, Expression and Purification of Chimeric Protein in Colorectal Cancer Treatment

Dana H, Mahmoodi Chalbatani G, Gharagouzloo E, Miri SR, Memari F, Rasoolzadeh R, Zinatizadeh MR, Kheirandish Zarandi P, Marmari V

Drug Design, Development and Therapy 2020, 14:309-329

Published Date: 23 January 2020

Progress in Understanding the Molecular Mechanisms Underlying the Antitumour Effects of Ivermectin

Liu J, Zhang K, Cheng L, Zhu H, Xu T

Drug Design, Development and Therapy 2020, 14:285-296

Published Date: 21 January 2020

Apatinib in Patients with Relapsed or Refractory Diffuse Large B Cell Lymphoma: A Phase II, Open-Label, Single-Arm, Prospective Study

Ma X, Li L, Zhang L, Fu X, Li X, Wang X, Wu J, Sun Z, Zhang X, Feng X, Chang Y, Zhou Z, Nan F, Zhang J, Li Z, Zhang M

Drug Design, Development and Therapy 2020, 14:275-284

Published Date: 22 January 2020

The Impact of Loading Dose on Outcome in Stroke Patients Receiving Low-Dose Tissue Plasminogen Activator Thrombolytic Therapy

Wong YS, Sung SF, Wu CS, Hsu YC, Su YH, Hung LC, Ong CT

Drug Design, Development and Therapy 2020, 14:257-263

Published Date: 17 January 2020

Enhancing Betulinic Acid Dissolution Rate and Improving Antitumor Activity via Nanosuspension Constructed by Anti-Solvent Technique

Li S, Zhang J, Fang Y, Yi J, Lu Z, Chen Y, Guo B

Drug Design, Development and Therapy 2020, 14:243-256

Published Date: 16 January 2020

Electrospun PLA Fibers Containing Metronidazole for Periodontal Disease

Budai-Szűcs M, Léber A, Cui L, Józó M, Vályi P, Burián K, Kirschweng B, Csányi E, Pukánszky B

Drug Design, Development and Therapy 2020, 14:233-242

Published Date: 16 January 2020

Discovery of a Novel Benzenesulfonamide Analogue That Inhibits Proliferation and Metastasis Against Ovarian Cancer OVCAR-8 Cells

Jia Y, Li M, Cao Y, Feng W, Li X, Xue W, Shi H

Drug Design, Development and Therapy 2020, 14:207-216

Published Date: 15 January 2020

Baicalin Ameliorates Dexamethasone-Induced Osteoporosis by Regulation of the RANK/RANKL/OPG Signaling Pathway

Zhao Y, Wang HL, Li TT, Yang F, Tzeng CM

Drug Design, Development and Therapy 2020, 14:195-206

Published Date: 15 January 2020

Curcumin Combined with Thalidomide Reduces Expression of STAT3 and Bcl-xL, Leading to Apoptosis in Acute Myeloid Leukemia Cell Lines

Mohammadi Kian M, Salemi M, Bahadoran M, Haghi A, Dashti N, Mohammadi S, Rostami S, Chahardouli B, Babakhani D, Nikbakht M

Drug Design, Development and Therapy 2020, 14:185-194

Published Date: 15 January 2020

Isoborneol Attenuates Low-Density Lipoprotein Accumulation and Foam Cell Formation in Macrophages

Wang Y, Li Z, Liu B, Wu R, Gong H, Su Z, Zhang S

Drug Design, Development and Therapy 2020, 14:167-173

Published Date: 15 January 2020

Aloin Inhibits the Proliferation and Migration of Gastric Cancer Cells by Regulating NOX2–ROS-Mediated Pro-Survival Signal Pathways

Wang Z, Tang T, Wang S, Cai T, Tao H, Zhang Q, Qi S, Qi Z

Drug Design, Development and Therapy 2020, 14:145-155

Published Date: 14 January 2020

Metabolic Stability Assessment of Larotrectinib Using Liquid Chromatography Tandem Mass Spectrometry

Attwa MW, Kadi AA, Darwish HW

Drug Design, Development and Therapy 2020, 14:111-119

Published Date: 10 January 2020

Suitability of Amoxicillin–Clavulanic Acid for Administration via Prolonged Infusion

Fawaz S, Dixon B, Barton S, Mohamed A, Nabhani-Gebara S

Drug Design, Development and Therapy 2020, 14:103-109

Published Date: 10 January 2020

Curcumin Attenuates Oxaliplatin-Induced Liver Injury and Oxidative Stress by Activating the Nrf2 Pathway

Lu Y, Wu S, Xiang B, Li L, Lin Y

Drug Design, Development and Therapy 2020, 14:73-85

Published Date: 9 January 2020

Sappanone A Protects Against Myocardial Ischemia Reperfusion Injury by Modulation of Nrf2

Shi X, Tao G, Ji L, Tian G

Drug Design, Development and Therapy 2020, 14:61-71

Published Date: 8 January 2020

Engineering of Naproxen Loaded Polymer Hybrid Enteric Microspheres for Modified Release Tablets: Development, Characterization, in silico Modelling and in vivo Evaluation

Hameed HA, Khan S, Shahid M, Ullah R, Bari A, Ali SS, Hussain Z, Sohail M, Khan SU, Htar TT

Drug Design, Development and Therapy 2020, 14:27-41

Published Date: 7 January 2020

NMMHC IIA Inhibition Ameliorates Cerebral Ischemic/Reperfusion-Induced Neuronal Apoptosis Through Caspase-3/ROCK1/MLC Pathway

Wang GY, Wang TZ, Zhang YY, Li F, Yu BY, Kou JP

Drug Design, Development and Therapy 2020, 14:13-25

Published Date: 6 January 2020