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Drug Design, Development and Therapy


Archive: Volume 9, 2015

Brivaracetam: review of its pharmacology and potential use as adjunctive therapy in patients with partial onset seizures [Corrigendum]

Mumoli L, Palleria C, Gasparini S, Citraro R, Labate A, Ferlazzo E, Gambardella A, De Sarro G, Russo E

Drug Design, Development and Therapy 2015, 9:6509-6510

Published Date: 18 December 2015

Association of systolic blood pressure drop with intravenous administration of itraconazole in children with hemato-oncologic disease

Lee HJ, Lee B, Park JD, Jeong HJ, Choi YH, Ju HY, Hong CR, Lee JW, Kim H, Suh DI, Park KD, Kang HJ, Shin HY, Ahn HS

Drug Design, Development and Therapy 2015, 9:6489-6495

Published Date: 17 December 2015

Effect of caffeic acid phenethyl ester on bone formation in the expanded inter-premaxillary suture

Kazancioglu HO, Aksakalli S, Ezirganli S, Birlik M, Esrefoglu M, Acar AH

Drug Design, Development and Therapy 2015, 9:6483-6488

Published Date: 21 December 2015

Effects of vitamin C treatment on collar-induced intimal thickening

Arun MZ, Üstünes L, Sevin G, Özer E

Drug Design, Development and Therapy 2015, 9:6461-6473

Published Date: 15 December 2015

Enhanced antitumoral activity of doxorubicin against lung cancer cells using biodegradable poly(butylcyanoacrylate) nanoparticles

Melguizo C, Cabeza L, Prados J, Ortiz R, Caba O, Rama AR, Delgado ÁV, Arias JL

Drug Design, Development and Therapy 2015, 9:6433-6444

Published Date: 14 December 2015

Autophagy facilitates lung adenocarcinoma resistance to cisplatin treatment by activation of AMPK/mTOR signaling pathway

Wu T, Wang MC, Jing L, Liu ZY, Guo H, Liu Y, Bai YY, Cheng YZ, Nan KJ, Liang X

Drug Design, Development and Therapy 2015, 9:6421-6431

Published Date: 14 December 2015

Idiopathic pulmonary fibrosis: current treatment options and critical appraisal of nintedanib

Bonella F, Stowasser S, Wollin L

Drug Design, Development and Therapy 2015, 9:6407-6419

Published Date: 14 December 2015

Phase II trial of docetaxel combined with nedaplatin for patients with recurrent and metastatic nasopharyngeal carcinoma

Peng PJ, Lv BJ, Tang C, Liao H, Lin Z, Liu YM, Wang ZH, Wang SY, Cheng ZB

Drug Design, Development and Therapy 2015, 9:6401-6405

Published Date: 10 December 2015

Identification of covalent active site inhibitors of dengue virus protease

Koh-Stenta X, Joy J, Wang SF, Kwek PZ, Wee JLK, Wan KF, Gayen S, Chen AS, Kang C, Lee MA, Poulsen A, Vasudevan SG, Hill J, Nacro K

Drug Design, Development and Therapy 2015, 9:6389-6399

Published Date: 10 December 2015

Effect of oral N-acetylcysteine on COPD patients with microsatellite polymorphism in the heme oxygenase-1 gene promoter

Zhang JQ, Zhang JQ, Fang LZ, Liu L, Fu WP, Dai LM

Drug Design, Development and Therapy 2015, 9:6379-6387

Published Date: 7 December 2015

Effects of intravitreal injection of netrin-1 in retinal neovascularization of streptozotocin-induced diabetic rats

Yu Y, Zou J, Han Y, Quyang L, He H, Hu P, Shao Y, Tu P

Drug Design, Development and Therapy 2015, 9:6363-6377

Published Date: 7 December 2015

Tanshinone IIA ameliorates dextran sulfate sodium-induced inflammatory bowel disease via the pregnane X receptor

Zhang X, Wang Y, Ma Z, Liang Q, Tang X, Hu D, Tan H, Xiao C, Gao Y

Drug Design, Development and Therapy 2015, 9:6343-6362

Published Date: 7 December 2015

Hypoglycemic effect and mechanism of honokiol on type 2 diabetic mice

Sun J, Fu X, Liu Y, Wang Y, Huo B, Guo Y, Gao X, Li W, Hu X

Drug Design, Development and Therapy 2015, 9:6327-6342

Published Date: 4 December 2015

Green tea extract as a treatment for patients with wild-type transthyretin amyloidosis: an observational study

aus dem Siepen F, Bauer R, Aurich M, Buss SJ, Steen H, Altland K, Katus HA, Kristen AV

Drug Design, Development and Therapy 2015, 9:6319-6325

Published Date: 4 December 2015

Ginkgo biloba extract mitigates liver fibrosis and apoptosis by regulating p38 MAPK, NF-κB/IκBα, and Bcl-2/Bax signaling

Wang YY, Wang R, Wang YJ, Peng RQ, Wu Y, Yuan YF

Drug Design, Development and Therapy 2015, 9:6303-6317

Published Date: 3 December 2015

Synthetic biology for pharmaceutical drug discovery

Trosset JY, Carbonell P

Drug Design, Development and Therapy 2015, 9:6285-6302

Published Date: 3 December 2015

Sulodexide therapy for the treatment of diabetic nephropathy, a meta-analysis and literature review

Li R, Xing J, Mu XJ, Wang H, Zhang L, Zhao Y, Zhang Y

Drug Design, Development and Therapy 2015, 9:6275-6283

Published Date: 3 December 2015

Enzymatic vitreolysis with recombinant tissue plasminogen activator for vitreomacular traction

Raczyńska D, Lipowski P, Zorena K, Skorek A, Glasner P

Drug Design, Development and Therapy 2015, 9:6259-6268

Published Date: 27 November 2015

Timosaponin B-II ameliorates diabetic nephropathy via TXNI P, mTOR, and NF-κB signaling pathways in alloxan-induced mice

Yuan YL, Guo CR, Cui LL, Ruan SX, Zhang CF, Ji D, Yang ZL, Li F

Drug Design, Development and Therapy 2015, 9:6247-6258

Published Date: 27 November 2015

Hyaluronic acid abrogates ethanol-dependent inhibition of collagen biosynthesis in cultured human fibroblasts

Donejko M, Przylipiak A, Rysiak E, Miltyk W, Galicka E, Przylipiak J, Zaręba I, Surazynski A

Drug Design, Development and Therapy 2015, 9:6225-6233

Published Date: 24 November 2015

Different effects of statins on induction of diabetes mellitus: an experimental study

Zhao W, Zhao SP

Drug Design, Development and Therapy 2015, 9:6211-6223

Published Date: 24 November 2015

Radiotherapy potentiation with weekly cisplatin compared to standard every 3 weeks cisplatin chemotherapy for locoregionally advanced head and neck squamous cell carcinoma 

Fayette J, Molin Y, Lavergne E, Montbarbon X, Racadot S, Poupart M, Ramade A, Zrounba P, Ceruse P, Pommier P

Drug Design, Development and Therapy 2015, 9:6203-6210

Published Date: 26 November 2015

Synthesis, structural characterization, and anticancer activity of a monobenzyltin compound against MCF-7 breast cancer cells

Fani S, Kamalidehghan B, Lo KM, Hashim NM, Chow KM, Ahmadipour F

Drug Design, Development and Therapy 2015, 9:6191-6201

Published Date: 23 November 2015

Spotlight on tavaborole for the treatment of onychomycosis

Jinna S, Finch J

Drug Design, Development and Therapy 2015, 9:6185-6190

Published Date: 20 November 2015

Prospective study on nanoparticle albumin-bound paclitaxel in advanced breast cancer: clinical results and biological observations in taxane-pretreated patients

Fabi A, Giannarelli D, Malaguti P, Ferretti G, Vari S, Papaldo P, Nisticò C, Caterino M, De Vita R, Mottolese M, Iacorossi L, Cognetti F

Drug Design, Development and Therapy 2015, 9:6177-6183

Published Date: 20 November 2015

Influence of glucosamine on the bioactivity of insulin delivered subcutaneously and in an oral nanodelivery system

Al-Kurdi ZI, Chowdhry BZ, Leharne SA, Qinna NA, Al Omari MMH, Badwan AA

Drug Design, Development and Therapy 2015, 9:6167-6176

Published Date: 19 November 2015

Efficacy and safety of a conversion from the original tacrolimus and mycophenolate mofetil to the generics Tacpan® and Mowel® after liver transplantation

Vollmar J, Bellmann MC, Darstein F, Hoppe-Lotichius M, Mittler J, Heise M, Rüttger B, Weyer V, Zimmermann A, Lang H, Galle PR, Zimmermann T

Drug Design, Development and Therapy 2015, 9:6139-6149

Published Date: 17 November 2015

DNAzyme-based probe for circulating microRNA detection in peripheral blood

Shao G, Ji S, Wu A, Liu C, Wang M, Zhang P, Jiao Q, Kang Y

Drug Design, Development and Therapy 2015, 9:6109-6117

Published Date: 16 November 2015

Protective effects of triptolide on retinal ganglion cells in a rat model of chronic glaucoma

Yang F, Wang DM, Wu LL, Li Y

Drug Design, Development and Therapy 2015, 9:6095-6107

Published Date: 16 November 2015

Apatinib for molecular targeted therapy in tumor

Zhang H

Drug Design, Development and Therapy 2015, 9:6075-6081

Published Date: 13 November 2015

A single-arm Phase II validation study of preventing oxaliplatin-induced hypersensitivity reactions by dexamethasone: the AVOID trial

Yoshida Y, Hirata K, Matsuoka H, Iwamoto S, Kotaka M, Fujita H, Aisu N, Hoshino S, Kosaka T, Maeda K, Kiyomi F, Yamashita Y

Drug Design, Development and Therapy 2015, 9:6067-6073

Published Date: 12 November 2015

Attenuation of myocardial fibrosis with curcumin is mediated by modulating expression of angiotensin II AT1/AT2 receptors and ACE2 in rats

Pang XF, Zhang LH, Bai F, Wang NP, Garner RE, McKallip RJ, Zhao ZQ

Drug Design, Development and Therapy 2015, 9:6043-6054

Published Date: 11 November 2015

Profile of suvorexant in the management of insomnia

Sutton EL

Drug Design, Development and Therapy 2015, 9:6035-6042

Published Date: 11 November 2015

6-Gingerol alleviates exaggerated vasoconstriction in diabetic rat aorta through direct vasodilation and nitric oxide generation

Ghareib SA, El-Bassossy HM, Elberry AA, Azhar A, Watson ML, Banjar ZM

Drug Design, Development and Therapy 2015, 9:6019-6026

Published Date: 9 November 2015

Glucose abnormalities in Asian patients with chronic hepatitis C

Bo Q, Orsenigo R, Wang J, Griffel L, Brass C

Drug Design, Development and Therapy 2015, 9:6009-6017

Published Date: 9 November 2015

Progesterone regulates the proliferation of breast cancer cells – in vitro evidence

Azeez JM, Sithul H, Hariharan I, Sreekumar S, Prabhakar J, Sreeja S, Pillai MR

Drug Design, Development and Therapy 2015, 9:5987-5999

Published Date: 9 November 2015

Phytocompounds and modulatory effects of Anacardium microcarpum (cajui) on antibiotic drugs used in clinical infections

Barbosa-Filho VM, Waczuk EP, Leite NF, Menezes IRA, da Costa JGM, Lacerda SR, Adedara IA, Coutinho HDM, Posser T, Kamdem JP

Drug Design, Development and Therapy 2015, 9:5965-5972

Published Date: 6 November 2015

Lentinus squarrosulus (Mont.) mycelium enhanced antioxidant status in rat model

Mhd Omar NA, Abdullah S, Abdullah N, Kuppusamy UR, Abdulla MA, Sabaratnam V

Drug Design, Development and Therapy 2015, 9:5957-5964

Published Date: 6 November 2015

Tumor-induced VEGF-C overexpression in retroperitoneal lymph nodes in VX2 carcinoma-bearing rabbits

Huang YW, Zhou Y, Lan CY, Wang Y, Feng YL, Luo RZ, Liu JH

Drug Design, Development and Therapy 2015, 9:5949-5956

Published Date: 5 November 2015

Systematic review and meta-analysis: bezafibrate in patients with primary biliary cirrhosis [Erratum]

Yin Q, Li J, Xia Y, Zhang R, Wang J, Lu W, Zhou Y, Zheng Y, Abudumijiti H, Chen R, Chen K, Li S, Liu T, Wang F, Lu J, Zhou Y, Guo C

Drug Design, Development and Therapy 2015, 9:5947-5948

Published Date: 9 November 2015

Efficacy and safety of ifosfamide-based chemotherapy for osteosarcoma: a meta-analysis

Fan XL, Cai GP, Zhu LL, Ding GM

Drug Design, Development and Therapy 2015, 9:5925-5932

Published Date: 4 November 2015

PACE4 regulates apoptosis in human prostate cancer cells via endoplasmic reticulum stress and mitochondrial signaling pathways

Yao Z, Sun B, Hong Q, Yan J, Mu D, Li J, Sheng H, Guo H

Drug Design, Development and Therapy 2015, 9:5911-5923

Published Date: 5 November 2015

Critical appraisal of Timothy grass pollen extract GRAZAX® in the management of allergic rhinitis

Scaparrotta A, Attanasi M, Petrosino MI, Di Filippo P, Di Pillo S, Chiarelli F

Drug Design, Development and Therapy 2015, 9:5897-5909

Published Date: 3 November 2015

In silico approach for the discovery of new PPARγ modulators among plant-derived polyphenols

Encinar JA, Fernández-Ballester G, Galiano-Ibarra V, Micol V

Drug Design, Development and Therapy 2015, 9:5877-5895

Published Date: 4 November 2015

Efficacy and tolerability of oral oxycodone and oxycodone/naloxone combination in opioid-naïve cancer patients: a propensity analysis

Lazzari M, Greco MT, Marcassa C, Finocchi S, Caldarulo C, Corli O

Drug Design, Development and Therapy 2015, 9:5863-5872

Published Date: 2 November 2015

Arsenic sulfide combined with JQ1, chemotherapy agents, or celecoxib inhibit gastric and colon cancer cell growth

Zhang L, Tong Y, Zhang X, Pan M, Chen S

Drug Design, Development and Therapy 2015, 9:5851-5862

Published Date: 30 October 2015

The relevance of piroxicam for the prevention and treatment of nonmelanoma skin cancer and its precursors

Campione E, Paternò EJ, Candi E, Falconi M, Costanza G, Diluvio L, Terrinoni A, Bianchi L, Orlandi A

Drug Design, Development and Therapy 2015, 9:5843-5850

Published Date: 29 October 2015

Prevalence of the rs7903146C>T polymorphism in TCF7L2 gene for prediction of type 2 diabetes risk among Iranians of different ethnicities

Allahdini M, Kamalidehghan B, Akbari L, Azadfar P, Rahmani A, Ahmadipour F, Meng GY, Masserrat A, Houshmand M

Drug Design, Development and Therapy 2015, 9:5835-5841

Published Date: 28 October 2015

Development of oral dispersible tablets containing prednisolone nanoparticles for the management of pediatric asthma

Chen YD, Liang ZY, Cen YY, Zhang H, Han MG, Tian YQ, Zhang J, Li SJ, Yang DS

Drug Design, Development and Therapy 2015, 9:5815-5825

Published Date: 20 November 2015

Curcuma purpurascens BI. rhizome accelerates rat excisional wound healing: involvement of Hsp70/Bax proteins, antioxidant defense, and angiogenesis activity

Rouhollahi E, Moghadamtousi SZ, Hajiaghaalipour F, Zahedifard M, Tayeby F, Awang K, Abdulla MA, Mohamed Z

Drug Design, Development and Therapy 2015, 9:5805-5813

Published Date: 27 October 2015

Empagliflozin in the treatment of type 2 diabetes: evidence to date

Shubrook JH, Baradar Bokaie B, Adkins SE

Drug Design, Development and Therapy 2015, 9:5793-5803

Published Date: 30 October 2015

Efficacy of trabectedin in advanced soft tissue sarcoma: beyond lipo- and leiomyosarcoma

De Sanctis R, Marrari A, Marchetti S, Mussi C, Balzarini L, Lutman FR, Daolio P, Bastoni S, Bertuzzi AF, Quagliuolo V, Santoro A

Drug Design, Development and Therapy 2015, 9:5785-5791

Published Date: 27 October 2015

Reductive metabolism of oxymatrine is catalyzed by microsomal CYP3A4

Liu W, Shi J, Zhu L, Dong L, Luo F, Zhao M, Wang Y, Hu M, Lu L, Liu Z

Drug Design, Development and Therapy 2015, 9:5771-5783

Published Date: 30 October 2015

Rationale and clinical utility of the darunavir–cobicistat combination in the treatment of HIV/AIDS

Putcharoen O, Do T, Avihingsanon A, Ruxrungtham K

Drug Design, Development and Therapy 2015, 9:5763-5769

Published Date: 23 October 2015

Efficacy of thrombomodulin for acute exacerbation of idiopathic pulmonary fibrosis and nonspecific interstitial pneumonia: a nonrandomized prospective study

Abe M, Tsushima K, Matsumura T, Ishiwata T, Ichimura Y, Ikari J, Terada J, Tada Y, Sakao S, Tanabe N, Tatsumi K

Drug Design, Development and Therapy 2015, 9:5755-5762

Published Date: 23 October 2015

Mechanism and pharmacological rescue of berberine-induced hERG channel deficiency

Yan M, Zhang KP, Shi YH, Feng LF, Lv L, Li BX

Drug Design, Development and Therapy 2015, 9:5737-5747

Published Date: 22 October 2015

4-Hydroxyisoleucine ameliorates an insulin resistant-like state in 3T3-L1 adipocytes by regulating TACE/TIMP3 expression

Gao F, Du W, Zafar MI, Shafqat RA, Jian L, Cai Q, Lu FR

Drug Design, Development and Therapy 2015, 9:5727-5736

Published Date: 20 October 2015

Brivaracetam: review of its pharmacology and potential use as adjunctive therapy in patients with partial onset seizures

Mumoli L, Palleria C, Gasparini S, Citraro R, Labate A, Ferlazzo E, Gambardella A, De Sarro G, Russo E

Drug Design, Development and Therapy 2015, 9:5719-5725

Published Date: 19 October 2015

Evaluation of the cardiovascular effects of varenicline in rats

Selçuk EB, Sungu M, Parlakpinar H, Ermiş N, Taslıdere E, Vardı N, Yalçınsoy M, Sagır M, Polat A, Karatas M, Kayhan-Tetik B

Drug Design, Development and Therapy 2015, 9:5705-5717

Published Date: 22 October 2015

Safety and pharmacokinetics of dicloxacillin in healthy Chinese volunteers following single and multiple oral doses

Wu GL, Zheng YL, Zhou HL, Hu XJ, Liu J, Zhai Y, Zhu MX, Wu LH, Shentu JZ

Drug Design, Development and Therapy 2015, 9:5687-5695

Published Date: 16 October 2015

Bifunctional fused polypeptide inhibits the growth and metastasis of breast cancer

Liang AL, Qian HL, Zhang TT, Zhou N, Wang HJ, Men XT, Qi W, Zhang PP, Fu M, Liang X, Lin C, Liu YJ

Drug Design, Development and Therapy 2015, 9:5671-5686

Published Date: 16 October 2015

The role of taxanes in triple-negative breast cancer: literature review [Corrigendum]

Mustacchi G, De Laurentiis M

Drug Design, Development and Therapy 2015, 9:5669-5670

Published Date: 19 October 2015

Adenoviral delivery of truncated MMP-8 fused with the hepatocyte growth factor mutant 1K1 ameliorates liver cirrhosis and promotes hepatocyte proliferation

Liu JH, Li JB, Fu WW, Tang JC, Feng X, Chen J, Liang YL, Jin RA, Xie AY, Cai XJ

Drug Design, Development and Therapy 2015, 9:5655-5667

Published Date: 16 October 2015

Development of PPAR-agonist GW0742 as antidiabetic drug: study in animals

Niu HS, Ku PM, Niu CS, Cheng JT, Lee KS

Drug Design, Development and Therapy 2015, 9:5625-5632

Published Date: 14 October 2015

Paeoniflorin inhibits human glioma cells via STAT3 degradation by the ubiquitin–proteasome pathway

Nie XH, Ou-yang J, Xing Y, Li DY, Dong XY, Liu RE, Xu RX

Drug Design, Development and Therapy 2015, 9:5611-5622

Published Date: 13 October 2015

Urinary kallidinogenase for the treatment of cerebral arterial stenosis

Zhao L, Zhao Y, Wan Q, Zhang H

Drug Design, Development and Therapy 2015, 9:5595-5600

Published Date: 13 October 2015

Acquired latent tuberculosis infection in psoriasis patients treated with etanercept in the People’s Republic of China

Li CR, Mao QX, Chen M, Jia WX, Yao X, Feng SY, Jia H, Gong JQ, Yang XY

Drug Design, Development and Therapy 2015, 9:5591-5594

Published Date: 12 October 2015

Arsenic sulfide inhibits cell migration and invasion of gastric cancer in vitro and in vivo

Zhang L, Kim S, Ding W, Tong Y, Zhang X, Pan M, Chen S

Drug Design, Development and Therapy 2015, 9:5579-5590

Published Date: 9 October 2015

Novel dehydroepiandrosterone troche supplementation improves the serum androgen profile of women undergoing in vitro fertilization

Keane KN, Hinchliffe PM, Namdar N, Conceicao JL, Newsholme P, Yovich JL

Drug Design, Development and Therapy 2015, 9:5569-5578

Published Date: 9 October 2015

Design, synthesis, and antitumor evaluation of histone deacetylase inhibitors with L-phenylglycine scaffold

Zhang Y, Li X, Hou J, Huang Y, Xu W

Drug Design, Development and Therapy 2015, 9:5553-5567

Published Date: 8 October 2015

Plumbagin suppresses epithelial to mesenchymal transition and stemness via inhibiting Nrf2-mediated signaling pathway in human tongue squamous cell carcinoma cells

Pan ST, Qin Y, Zhou ZW, He ZX, Zhang X, Yang T, Yang YX, Wang D, Zhou SF, Qiu JX

Drug Design, Development and Therapy 2015, 9:5511-5551

Published Date: 5 October 2015

Neuroprotective potential of ferulic acid in the rotenone model of Parkinson’s disease

Ojha S, Javed H, Azimullah S, Abul Khair SB, Haque ME

Drug Design, Development and Therapy 2015, 9:5499-5510

Published Date: 7 October 2015

3-Coumaranone derivatives as inhibitors of monoamine oxidase

Van Dyk AS, Petzer JP, Petzer A, Legoabe LJ

Drug Design, Development and Therapy 2015, 9:5479-5489

Published Date: 3 October 2015

A novel small-molecule inhibitor of HIV-1 entry

Heredia A, Latinovic OS, Barbault F, de Leeuw EPH

Drug Design, Development and Therapy 2015, 9:5469-5478

Published Date: 1 October 2015

Maraviroc: a review of its use in HIV infection and beyond

Woollard SM, Kanmogne GD

Drug Design, Development and Therapy 2015, 9:5447-5468

Published Date: 1 October 2015

A proposal for an individualized pharmacogenetic-guided isoniazid dosage regimen for patients with tuberculosis

Jung JA, Kim TE, Lee H, Jeong BH, Park HY, Jeon K, Kwon OJ, Ko JW, Choi R, Woo HI, Koh WJ, Lee SY

Drug Design, Development and Therapy 2015, 9:5433-5438

Published Date: 30 September 2015

Systematic review and meta-analysis: bezafibrate in patients with primary biliary cirrhosis

Yin Q, Li J, Xia Y, Zhang R, Wang J, Lu W, Zhou Y, Zheng Y, Abudumijiti H, Chen R, Chen K, Li S, Liu T, Wang F, Lu J, Zhou Y, Guo C

Drug Design, Development and Therapy 2015, 9:5407-5419

Published Date: 30 September 2015

Ghrelin reduces liver impairment in a model of concanavalin A-induced acute hepatitis in mice

Mao YQ, Wang JB, Yu FJ, Cheng J, Li HQ, Guo CY, Fan XM

Drug Design, Development and Therapy 2015, 9:5385-5396

Published Date: 28 September 2015

Collagenase IV plays an important role in regulating hair cycle by inducing VEGF, IGF-1, and TGF-β expression

Hou C, Miao Y, Wang J, Wang X, Chen CY, Hu ZQ

Drug Design, Development and Therapy 2015, 9:5373-5383

Published Date: 25 September 2015

Efficacy and safety of a vaginal medicinal product containing three strains of probiotic bacteria: a multicenter, randomized, double-blind, and placebo-controlled trial

Tomusiak A, Strus M, Heczko PB, Adamski P, Stefański G, Mikołajczyk-Cichońska A, Suda-Szczurek M

Drug Design, Development and Therapy 2015, 9:5345-5354

Published Date: 25 September 2015

Effect of curcumin on aging retinal pigment epithelial cells

Zhu W, Wu Y, Meng YF, Wang JY, Xu M, Tao JJ, Lu J

Drug Design, Development and Therapy 2015, 9:5337-5344

Published Date: 25 September 2015

Investigation of the bioequivalence of montelukast chewable tablets after a single oral administration using a validated LC-MS/MS method

Zaid AN, Abualhasan MN, Watson DG, Mousa A, Ghazal N, Bustami R

Drug Design, Development and Therapy 2015, 9:5315-5321

Published Date: 23 September 2015

Chamaejasmin B exerts anti-MDR effect in vitro and in vivo via initiating mitochondria-dependant intrinsic apoptosis pathway

Wang YJ, Li Q, Xiao HB, Li YJ, Yang Q, Kan XX, Chen Y, Liu XN, Weng XG, Chen X, Cai WY, Guo Y, Huang HF, Zhu XX

Drug Design, Development and Therapy 2015, 9:5301-5313

Published Date: 22 September 2015

The rapid effects of budesonide plus formoterol in patients with obstructive airway diseases

Bayiz H, Ozkaya S, Dirican A, Ece F

Drug Design, Development and Therapy 2015, 9:5287-5290

Published Date: 21 September 2015

Exposure–outcome analysis in depressed patients treated with paroxetine using population pharmacokinetics

Kim JR, Woo HI, Chun MR, Lim SW, Kim HD, Na HS, Chung MW, Myung W, Lee SY, Kim DK

Drug Design, Development and Therapy 2015, 9:5247-5254

Published Date: 16 September 2015

Companion diagnostics and molecular imaging-enhanced approaches for oncology clinical trials

Van Heertum RL, Scarimbolo R, Ford R, Berdougo E, O’Neal M

Drug Design, Development and Therapy 2015, 9:5215-5223

Published Date: 11 September 2015

Eliglustat tartrate for the treatment of adults with type 1 Gaucher disease [Corrigendum]

Bennett LL, Turcotte K

Drug Design, Development and Therapy 2015, 9:5213-5214

Published Date: 11 September 2015

Dabigatran etexilate retards the initiation and progression of atherosclerotic lesions and inhibits the expression of oncostatin M in apolipoprotein E-deficient mice

Preusch MR, Ieronimakis N, Wijelath ES, Cabbage S, Ricks J, Bea F, Reyes M, van Ryn J, Rosenfeld ME

Drug Design, Development and Therapy 2015, 9:5203-5211

Published Date: 10 September 2015

Pentoxifylline and electromagnetic field improved bone fracture healing in rats

Atalay Y, Gunes N, Guner MD, Akpolat V, Celik MS, Guner R

Drug Design, Development and Therapy 2015, 9:5195-5201

Published Date: 9 September 2015

Exposure–response model for sibutramine and placebo: suggestion for application to long-term weight-control drug development

Han S, Jeon S, Hong T, Lee J, Bae SH, Park WS, Park G, Youn S, Jang DY, Kim KS, Yim DS

Drug Design, Development and Therapy 2015, 9:5185-5194

Published Date: 9 September 2015

Regulation of bone formation by baicalein via the mTORC1 pathway

Li SF, Tang JJ, Chen J, Zhang P, Wang T, Chen TY, Yan B, Huang B, Wang L, Huang MJ, Zhang ZM, Jin DD

Drug Design, Development and Therapy 2015, 9:5169-5183

Published Date: 9 September 2015

The IL-17A G-197A and IL-17F 7488T/C polymorphisms are associated with increased risk of cancer in Asians: a meta-analysis

Wang H, Zhang Y, Liu Z, Zhang Y, Zhao H, Du S

Drug Design, Development and Therapy 2015, 9:5159-5168

Published Date: 24 September 2015

Icariside II ameliorates diabetic nephropathy in streptozotocin-induced diabetic rats

Tian W, Lei H, Guan R, Xu Y, Li H, Wang L, Yang B, Gao Z, Xin Z

Drug Design, Development and Therapy 2015, 9:5147-5157

Published Date: 7 September 2015

Novel synthesizing method of pH-dependent doxorubicin-loaded anti-CD22-labelled drug delivery nanosystem

Sun M, Wang J, Lu Q, Xia G, Zhang Y, Song L, Fang Y

Drug Design, Development and Therapy 2015, 9:5123-5133

Published Date: 7 September 2015

Anthocyanins inhibit high-glucose-induced cholesterol accumulation and inflammation by activating LXRα pathway in HK-2 cells

Du C, Shi Y, Ren Y, Wu H, Yao F, Wei J, Wu M, Hou Y, Duan H

Drug Design, Development and Therapy 2015, 9:5099-5113

Published Date: 4 September 2015

Phase III study of pasireotide long-acting release in patients with metastatic neuroendocrine tumors and carcinoid symptoms refractory to available somatostatin analogues

Wolin EM, Jarzab B, Eriksson B, Walter T, Toumpanakis C, Morse MA, Tomassetti P, Weber MM, Fogelman DR, Ramage J, Poon D, Gadbaw B, Li J, Pasieka JL, Mahamat A, Swahn F, Newell-Price J, Mansoor W, Öberg K

Drug Design, Development and Therapy 2015, 9:5075-5086

Published Date: 3 September 2015

Paeonia lactiflora Pall. protects against ANIT-induced cholestasis by activating Nrf2 via PI3K/Akt signaling pathway

Ma X, Zhao Y, Zhu Y, Chen Z, Wang J, Li R, Chen C, Wei S, Li J, Liu B, Wang R, Li Y, Wang L, Xiao X

Drug Design, Development and Therapy 2015, 9:5061-5074

Published Date: 2 September 2015

Inhibition of HIV-1 by curcumin A, a novel curcumin analog

Kumari N, Kulkarni AA, Lin X, McLean C, Ammosova T, Ivanov A, Hipolito M, Nekhai S, Nwulia E

Drug Design, Development and Therapy 2015, 9:5051-5060

Published Date: 3 September 2015

Pharmacokinetic and nephroprotective benefits of using Schisandra chinensis extracts in a cyclosporine A-based immune-suppressive regime

Lai Q, Wei JB, Mahmoodurrahman M, Zhang CX, Quan SJ, Li TM, Yu Y

Drug Design, Development and Therapy 2015, 9:4997-5018

Published Date: 28 August 2015

CXCR4 in breast cancer: oncogenic role and therapeutic targeting

Xu C, Zhao H, Chen H, Yao Q

Drug Design, Development and Therapy 2015, 9:4953-4964

Published Date: 28 August 2015

Insight into the mechanism of polyphenols on the activity of HMGR by molecular docking

Islam B, Sharma C, Adem A, Aburawi EH, Ojha S

Drug Design, Development and Therapy 2015, 9:4943-4951

Published Date: 28 August 2015

The effect of curcumin and its nanoformulation on adjuvant-induced arthritis in rats

Zheng ZL, Sun YH, Liu ZL, Zhang MQ, Li CQ, Cai H

Drug Design, Development and Therapy 2015, 9:4931-4942

Published Date: 27 August 2015

Immunosuppressive effects of the standardized extract of Phyllanthus amarus on cellular immune responses in Wistar-Kyoto rats

Ilangkovan M, Jantan I, Mesaik MA, Bukhari SNA

Drug Design, Development and Therapy 2015, 9:4917-4930

Published Date: 26 August 2015

Profile of omalizumab in the treatment of chronic spontaneous urticaria

Labrador-Horrillo M, Ferrer M

Drug Design, Development and Therapy 2015, 9:4909-4915

Published Date: 25 August 2015

Met tyrosine kinase inhibitor, PF-2341066, suppresses growth and invasion of nasopharyngeal carcinoma

Zhao Y, Zhang J, Tian Y, Xue C, Hu Z, Zhang L

Drug Design, Development and Therapy 2015, 9:4897-4907

Published Date: 26 August 2015

Hydrogen sulfide-releasing naproxen suppresses colon cancer cell growth and inhibits NF-κB signaling

Kodela R, Nath N, Chattopadhyay M, Nesbitt DE, Velázquez-Martínez CA, Kashfi K

Drug Design, Development and Therapy 2015, 9:4873-4882

Published Date: 24 August 2015

Blood pyrrole-protein adducts as a diagnostic and prognostic index in pyrrolizidine alkaloid-hepatic sinusoidal obstruction syndrome

Gao H, Ruan JQ, Chen J, Li N, Ke CQ, Ye Y, Lin G, Wang JY

Drug Design, Development and Therapy 2015, 9:4861-4868

Published Date: 25 August 2015

Nonalcoholic steatohepatitis: emerging targeted therapies to optimize treatment options

Milic S, Mikolasevic I, Krznaric-Zrnic I, Stanic M, Poropat G, Stimac D, Vlahovic-Palcevski V, Orlic L

Drug Design, Development and Therapy 2015, 9:4835-4845

Published Date: 20 August 2015

How we make cell therapy in Italy

Montemurro T, Viganò M, Budelli S, Montelatici E, Lavazza C, Marino L, Parazzi V, Lazzari L, Giordano R

Drug Design, Development and Therapy 2015, 9:4825-4834

Published Date: 20 August 2015

Role of short-acting nitroglycerin in the management of ischemic heart disease

Boden WE, Padala SK, Cabral KP, Buschmann IR, Sidhu MS

Drug Design, Development and Therapy 2015, 9:4793-4805

Published Date: 19 August 2015

High glucose inhibits ClC-2 chloride channels and attenuates cell migration of rat keratinocytes

Pan F, Guo R, Cheng W, Chai L, Wang W, Cao C, Li S

Drug Design, Development and Therapy 2015, 9:4779-4791

Published Date: 28 August 2015

Effects of chalcone derivatives on players of the immune system

Lee JS, Bukhari SNA, Fauzi NM

Drug Design, Development and Therapy 2015, 9:4761-4778

Published Date: 19 August 2015

Death receptor and mitochondria-mediated hepatocyte apoptosis underlies liver dysfunction in rats exposed to organic pollutants from drinking water

Yang GH, Zhou ZW, Cen YL, Gui XL, Zeng QB, Ao YX, Li Q, Wang SR, Li J, Zhang AH

Drug Design, Development and Therapy 2015, 9:4719-4733

Published Date: 18 August 2015

Development of telmisartan in the therapy of spinal cord injury: pre-clinical study in rats

Lin CM, Tsai JT, Chang CK, Cheng JT, Lin JW

Drug Design, Development and Therapy 2015, 9:4709-4717

Published Date: 14 August 2015

Paget’s disease of bone: an osteoimmunological disorder?

Numan MS, Amiable N, Brown JP, Michou L

Drug Design, Development and Therapy 2015, 9:4695-4707

Published Date: 14 August 2015

Enhancement of absorption and bioavailability of echinacoside by verapamil or clove oil

Shen JY, Yang XL, Yang ZL, Kou JP, Li F

Drug Design, Development and Therapy 2015, 9:4685-4693

Published Date: 14 August 2015

Treatment with metformin and a dipeptidyl peptidase-4 inhibitor elevates apelin levels in patients with type 2 diabetes mellitus

Fan YJ, Zhang Y, Li XS, Zheng H, Song YP, Zhang N, Shen CF, Fan XF, Ren FD, Shen JY, Ren GG, Yang JL

Drug Design, Development and Therapy 2015, 9:4679-4683

Published Date: 14 August 2015

Lefty-1 alleviates TGF-β1-induced fibroblast–myofibroblast transdifferentiation in NRK-49F cells

Zhang LJ, Zhang J, Xu CG, Zhou XJ, Wang W, Zheng RP, Hu W, Wu P

Drug Design, Development and Therapy 2015, 9:4669-4678

Published Date: 14 August 2015

Myofibrotic malformation vessels: unique angiodysplasia toward the progression of hemorrhoidal disease

Li SL, Jing FY, Ma LL, Guo LL, Na F, An SL, Ye Y, Yang JM, Bao M, Kang D, Sun XL, Deng YJ

Drug Design, Development and Therapy 2015, 9:4649-4656

Published Date: 13 August 2015

Eliglustat tartrate for the treatment of adults with type 1 Gaucher disease

Bennett LL, Turcotte K

Drug Design, Development and Therapy 2015, 9:4639-4647

Published Date: 18 August 2015

PTEN insufficiency modulates ER+ breast cancer cell cycle progression and increases cell growth in vitro and in vivo

Chiang KC, Chen HY, Hsu SY, Pang JHS, Wang SY, Hsu JT, Yeh TS, Chen LW, Kuo SF, Sun CC, Lee JM, Yeh CN, Juang HH

Drug Design, Development and Therapy 2015, 9:4631-4638

Published Date: 13 August 2015

RGD-modified liposomes enhance efficiency of aclacinomycin A delivery: evaluation of their effect in lung cancer

Feng C, Li X, Dong C, Zhang X, Zhang X, Gao Y

Drug Design, Development and Therapy 2015, 9:4613-4620

Published Date: 11 August 2015

Relaxin inhibits cardiac fibrosis and endothelial–mesenchymal transition via the Notch pathway

Zhou X, Chen X, Cai JJ, Chen LZ, Gong YS, Wang LX, Gao Z, Zhang HQ, Huang WJ, Zhou H

Drug Design, Development and Therapy 2015, 9:4599-4611

Published Date: 11 August 2015

Ceftobiprole for the treatment of pneumonia: a European perspective

Liapikou A, Cillóniz C, Torres A

Drug Design, Development and Therapy 2015, 9:4565-4572

Published Date: 18 August 2015

Effects of amoxicillin/clavulanic acid on the pharmacokinetics of valproic acid

Lee SY, Huh W, Jung JA, Yoo HM, Ko JW, Kim JR

Drug Design, Development and Therapy 2015, 9:4559-4563

Published Date: 10 August 2015

Navigating the chemical space of dipeptidyl peptidase-4 inhibitors

Shoombuatong W, Prachayasittikul V, Anuwongcharoen N, Songtawee N, Monnor T, Prachayasittikul S, Prachayasittikul V, Nantasenamat C

Drug Design, Development and Therapy 2015, 9:4515-4549

Published Date: 10 August 2015

Clinical development of galunisertib (LY2157299 monohydrate), a small molecule inhibitor of transforming growth factor-beta signaling pathway

Herbertz S, Sawyer JS, Stauber AJ, Gueorguieva I, Driscoll KE, Estrem ST, Cleverly AL, Desaiah D, Guba SC, Benhadji KA, Slapak CA, Lahn MM

Drug Design, Development and Therapy 2015, 9:4479-4499

Published Date: 10 August 2015

Novel targeting of PEGylated liposomes for codelivery of TGF-β1 siRNA and four antitubercular drugs to human macrophages for the treatment of mycobacterial infection: a quantitative proteomic study

Niu NK, Yin JJ, Yang YX, Wang ZL, Zhou ZW, He ZX, Chen XW, Zhang XJ, Duan W, Yang TX, Zhou SF

Drug Design, Development and Therapy 2015, 9:4441-4470

Published Date: 7 August 2015

Transarterial chemoembolization versus hepatic resection in hepatocellular carcinoma treatment: a meta-analysis

Tian X, Dai Y, Wang D, Zhang L, Sui C, Meng F, Jiang S, Liu Y, Jiang Y

Drug Design, Development and Therapy 2015, 9:4431-4440

Published Date: 10 August 2015

High-throughput sequencing of 16S rDNA amplicons characterizes bacterial composition in cerebrospinal fluid samples from patients with purulent meningitis

Liu A, Wang C, Liang Z, Zhou ZW, Wang L, Ma Q, Wang G, Zhou SF, Wang Z

Drug Design, Development and Therapy 2015, 9:4417-4429

Published Date: 7 August 2015

Tongguan capsule ameliorates coronary artery stenosis in a 40-year-old woman

Ma H, Wang L, Huang DZ, Liu GQ, Zhang MZ

Drug Design, Development and Therapy 2015, 9:4413-4416

Published Date: 10 August 2015

High-throughput virtual screening with e-pharmacophore and molecular simulations study in the designing of pancreatic lipase inhibitors

Veeramachaneni GK, Raj KK, Chalasani LM, Bondili JS, Talluri VR

Drug Design, Development and Therapy 2015, 9:4397-4412

Published Date: 6 August 2015

The role of aflibercept in the management of diabetic macular edema

Chang AA, Hong T, Ewe SY, Bahrami B, Broadhead GK

Drug Design, Development and Therapy 2015, 9:4389-4396

Published Date: 6 August 2015

Gamma scintigraphic evaluation of floating gastroretentive tablets of metformin HCl using a combination of three natural polymers in rabbits

Razavi M, Karimian H, Yeong CH, Chung LY, Nyamathulla S, Noordin MI

Drug Design, Development and Therapy 2015, 9:4373-4386

Published Date: 6 August 2015

The role of taxanes in triple-negative breast cancer: literature review

Mustacchi G, De Laurentiis M

Drug Design, Development and Therapy 2015, 9:4303-4318

Published Date: 5 August 2015

Hidden costs of antiretroviral treatment: the public health efficiency of drug packaging

Andreu-Crespo À, Llibre JM, Cardona-Peitx G, Sala-Piñol F, Clotet B, Bonafont-Pujol X

Drug Design, Development and Therapy 2015, 9:4287-4290

Published Date: 5 August 2015

Development of megestrol acetate solid dispersion nanoparticles for enhanced oral delivery by using a supercritical antisolvent process

Ha ES, Kim JS, Baek I, Yoo JW, Jung Y, Moon HR, Kim MS

Drug Design, Development and Therapy 2015, 9:4269-4277

Published Date: 4 August 2015

Design, synthesis, and anti-melanogenic effects of (E)-2-benzoyl-3-(substituted phenyl)acrylonitriles

Yun HY, Kim DH, Son S, Ullah S, Kim SJ, Kim YJ, Yoo JW, Jung YJ, Chun P, Moon HR

Drug Design, Development and Therapy 2015, 9:4259-4268

Published Date: 4 August 2015

Colon-targeted delivery of piceatannol enhances anti-colitic effects of the natural product: potential molecular mechanisms for therapeutic enhancement

Yum S, Jeong S, Lee S, Nam J, Kim W, Yoo JW, Kim MS, Lee BL, Jung Y

Drug Design, Development and Therapy 2015, 9:4247-4258

Published Date: 4 August 2015

Advances in cancer pain from bone metastasis

Zhu XC, Zhang JL, Ge CT, Yu YY, Wang P, Yuan TF, Fu CY

Drug Design, Development and Therapy 2015, 9:4239-4245

Published Date: 18 August 2015

Evaluation of glycine-bearing celecoxib derivatives as a colon-specific mutual prodrug acting on nuclear factor-κB, an anti-inflammatory target

Lee S, Lee Y, Kim W, Nam J, Jeong S, Yoo JW, Kim MS, Moon HR, Jung Y

Drug Design, Development and Therapy 2015, 9:4227-4237

Published Date: 7 August 2015

Characterization of cubosomes as a targeted and sustained transdermal delivery system for capsaicin

Peng X, Zhou Y, Han K, Qin L, Dian L, Li G, Pan X, Wu C

Drug Design, Development and Therapy 2015, 9:4209-4218

Published Date: 3 August 2015

Nutrigenomic effects of edible bird’s nest on insulin signaling in ovariectomized rats

Hou ZP, Imam MU, Ismail M, Ooi DJ, Ideris A, Mahmud R

Drug Design, Development and Therapy 2015, 9:4115-4125

Published Date: 14 August 2015

Celecoxib coupled to dextran via a glutamic acid linker yields a polymeric prodrug suitable for colonic delivery

Lee Y, Kim J, Kim W, Nam J, Jeong S, Lee S, Yoo JW, Kim MS, Jung Y

Drug Design, Development and Therapy 2015, 9:4105-4113

Published Date: 30 July 2015

20(S)-ginsenoside Rg3 promotes senescence and apoptosis in gallbladder cancer cells via the p53 pathway

Zhang F, Li M, Wu X, Hu Y, Cao Y, Wang X, Xiang S, Li H, Jiang L, Tan Z, Lu W, Weng H, Shu Y, Gong W, Wang X, Zhang Y, Shi W, Dong P, Gu J, Liu Y

Drug Design, Development and Therapy 2015, 9:3969-3987

Published Date: 10 August 2015

Improved oral absorption of cilostazol via sulfonate salt formation with mesylate and besylate

Seo JH, Park JB, Choi WK, Park S, Sung YJ, Oh E, Bae SK

Drug Design, Development and Therapy 2015, 9:3961-3968

Published Date: 30 July 2015

Edible bird’s nest attenuates procoagulation effects of high-fat diet in rats

Yida Z, Imam MU, Ismail M, Ismail N, Hou ZP

Drug Design, Development and Therapy 2015, 9:3951-3959

Published Date: 29 July 2015

Combined treatment with olmesartan medoxomil and amlodipine besylate attenuates atherosclerotic lesion progression in a model of advanced atherosclerosis

Sievers P, Uhlmann L, Korkmaz-Icöz S, Fastner C, Bea F, Blessing E, Katus HA, Preusch MR

Drug Design, Development and Therapy 2015, 9:3935-3942

Published Date: 29 July 2015

Gallic acid attenuates dextran sulfate sodium-induced experimental colitis in BALB/c mice

Pandurangan AK, Mohebali N, Norhaizan ME, Looi CY

Drug Design, Development and Therapy 2015, 9:3923-3934

Published Date: 30 July 2015

The chemopreventive potential of Curcuma purpurascens rhizome in reducing azoxymethane-induced aberrant crypt foci in rats

Rouhollahi E, Moghadamtousi SZ, Al-Henhena N, Kunasegaran T, Hasanpourghadi M, Looi CY, Abd Malek SN, Awang K, Abdulla MA, Mohamed Z

Drug Design, Development and Therapy 2015, 9:3911-3922

Published Date: 27 July 2015

Zinc supplementation induces apoptosis and enhances antitumor efficacy of docetaxel in non-small-cell lung cancer

Kocdor H, Ates H, Aydin S, Cehreli R, Soyarat F, Kemanli P, Harmanci D, Cengiz H, Kocdor MA

Drug Design, Development and Therapy 2015, 9:3899-3909

Published Date: 27 July 2015

Aterofisiol® in carotid plaque evolution

Amato B, Compagna R, Amato M, Gallelli L, de Franciscis S, Serra R

Drug Design, Development and Therapy 2015, 9:3877-3884

Published Date: 23 July 2015

Dendrimer-coupled sonophoresis-mediated transdermal drug-delivery system for diclofenac

Huang B, Dong WJ, Yang GY, Wang W, Ji CH, Zhou FN

Drug Design, Development and Therapy 2015, 9:3867-3876

Published Date: 23 July 2015

The brain signature of paracetamol in healthy volunteers: a double-blind randomized trial

Pickering G, Kastler A, Macian N, Pereira B, Valabrègue R, Lehericy S, Boyer L, Dubray C, Jean B

Drug Design, Development and Therapy 2015, 9:3853-3862

Published Date: 23 July 2015

Navigating into the binding pockets of the HER family protein kinases: discovery of novel EGFR inhibitor as antitumor agent

Liu W, Ning JF, Meng QW, Hu J, Zhao YB, Liu C, Cai L

Drug Design, Development and Therapy 2015, 9:3837-3851

Published Date: 23 July 2015

Effect of lactoferrin protein on red blood cells and macrophages: mechanism of parasite–host interaction

Anand N, Kanwar RK, Dubey ML, Vahishta RK, Sehgal R, Verma AK, Kanwar JR

Drug Design, Development and Therapy 2015, 9:3821-3835

Published Date: 27 July 2015

A new recombinant factor VIII: from genetics to clinical use

Kannicht C, Kohla G, Tiemeyer M, Walter O, Sandberg H

Drug Design, Development and Therapy 2015, 9:3817-3819

Published Date: 23 July 2015

Colon-targeted delivery of budesonide using dual pH- and time-dependent polymeric nanoparticles for colitis therapy

Naeem M, Choi MJ, Cao J, Lee Y, Ikram M, Yoon S, Lee J, Moon HR, Kim MS, Jung YJ, Yoo JW

Drug Design, Development and Therapy 2015, 9:3789-3799

Published Date: 21 July 2015

Design, development, drug-likeness, and molecular docking studies of novel piperidin-4-imine derivatives as antitubercular agents

Revathi R, Venkatesha Perumal R, Pai KSR, Arunkumar G, Sriram D, Kini SG

Drug Design, Development and Therapy 2015, 9:3779-3787

Published Date: 21 July 2015

Escherichia coli Nissle 1917 bacterial ghosts retain crucial surface properties and express chlamydial antigen: an imaging study of a delivery system for the ocular surface

Montanaro J, Inic-Kanada A, Ladurner A, Stein E, Belij S, Bintner N, Schlacher S, Schuerer N, Mayr UB, Lubitz W, Leisch N, Barisani-Asenbauer T

Drug Design, Development and Therapy 2015, 9:3741-3754

Published Date: 21 July 2015

Clinicopathological significance of matrix metalloproteinase-7 protein expression in esophageal cancer: a meta-analysis

Miao S, Zhou SY, Han CS, Zhang LN, Sun HB, Yang B

Drug Design, Development and Therapy 2015, 9:3729-3740

Published Date: 20 July 2015

Targeting brain cells with glutathione-modulated nanoliposomes: in vitro and in vivo study

Salem HF, Ahmed SM, Hassaballah AE, Omar MM

Drug Design, Development and Therapy 2015, 9:3705-3727

Published Date: 20 July 2015

Mechanisms underlying probucol-induced hERG-channel deficiency

Shi YQ, Yan CC, Zhang X, Yan M, Liu LR, Geng HZ, Lv L, Li BX

Drug Design, Development and Therapy 2015, 9:3695-3704

Published Date: 20 July 2015

Synthesis, antimicrobial and in vitro antitumor activities of a series of 1,2,3-thiadiazole and 1,2,3-selenadiazole derivatives

Mhaidat NM, Al-Smadi M, Al-Momani F, Alzoubi KH, Mansi I, Al-Balas Q

Drug Design, Development and Therapy 2015, 9:3645-3652

Published Date: 16 July 2015

2-acetylphenol analogs as potent reversible monoamine oxidase inhibitors

Legoabe LJ, Petzer A, Petzer JP

Drug Design, Development and Therapy 2015, 9:3635-3644

Published Date: 15 July 2015

Downregulation of miR203 induces overexpression of PIK3CA and predicts poor prognosis of gastric cancer patients

Liang M, Shi B, Liu J, He L, Yi G, Zhou L, Yu G, Zhou X

Drug Design, Development and Therapy 2015, 9:3607-3616

Published Date: 16 July 2015

Apparent Km of mitochondria for oxygen computed from Vmax measured in permeabilized muscle fibers is lower in water enriched in oxygen by electrolysis than injection

Zoll J, Bouitbir J, Sirvent P, Klein A, Charton A, Jimenez L, Péronnet FR, Geny B, Richard R

Drug Design, Development and Therapy 2015, 9:3589-3597

Published Date: 13 July 2015

Wound healing: a new perspective on glucosylated tetrahydrocurcumin

Bhaskar Rao A, Prasad E, Deepthi SS, Haritha V, Ramakrishna S, Madhusudan K, Surekha MV, Venkata Rao YSR

Drug Design, Development and Therapy 2015, 9:3579-3588

Published Date: 13 July 2015

Effect of Clausena excavata Burm. f. (Rutaceae) leaf extract on wound healing and antioxidant activity in rats

Albaayit SFA, Abba Y, Rasedee A, Abdullah N

Drug Design, Development and Therapy 2015, 9:3507-3518

Published Date: 13 July 2015

Phenolic indeno[1,2-b]indoles as ABCG2-selective potent and non-toxic inhibitors stimulating basal ATPase activity

Gozzi GJ, Bouaziz Z, Winter E, Daflon-Yunes N, Honorat M, Guragossian N, Marminon C, Valdameri G, Bollacke A, Guillon J, Pinaud N, Marchivie M, Cadena SM, Jose J, Le Borgne M, Di Pietro A

Drug Design, Development and Therapy 2015, 9:3481-3495

Published Date: 3 July 2015

Adaptive evolution and elucidating the potential inhibitor against schizophrenia to target DAOA (G72) isoforms

Sehgal SA, Mannan S, Kanwal S, Naveed I, Mir A

Drug Design, Development and Therapy 2015, 9:3471-3480

Published Date: 3 July 2015

Selective use of vandetanib in the treatment of thyroid cancer

Fallahi P, Di Bari F, Ferrari SM, Spisni R, Materazzi G, Miccoli P, Benvenga S, Antonelli A

Drug Design, Development and Therapy 2015, 9:3459-3470

Published Date: 3 July 2015

Animal models of ischemic stroke and their application in clinical research

Fluri F, Schuhmann MK, Kleinschnitz C

Drug Design, Development and Therapy 2015, 9:3445-3454

Published Date: 2 July 2015

Evaluation of the efficacy and safety of three dosing regimens of agalsidase alfa enzyme replacement therapy in adults with Fabry disease

Goláň L, Goker-Alpan O, Holida M, Kantola I, Klopotowski M, Kuusisto J, Linhart A, Musial J, Nicholls K, Gonzalez-Rodriguez D, Sharma R, Vujkovac B, Chang P, Wijatyk A

Drug Design, Development and Therapy 2015, 9:3435-3444

Published Date: 8 July 2015

Pharmacokinetics, pharmacodynamics, and safety of lesinurad, a selective uric acid reabsorption inhibitor, in healthy adult males

Shen Z, Rowlings C, Kerr B, Hingorani V, Manhard K, Quart B, Yeh LT, Storgard C

Drug Design, Development and Therapy 2015, 9:3423-3434

Published Date: 2 July 2015

Effect of vitamin C on inflammation and metabolic markers in hypertensive and/or diabetic obese adults: a randomized controlled trial

Ellulu MS, Rahmat A, Patimah I, Khaza’ai H, Abed Y

Drug Design, Development and Therapy 2015, 9:3405-3412

Published Date: 1 July 2015

Discovery of 3-n-butyl-2,3-dihydro-1H-isoindol-1-one as a potential anti-ischemic stroke agent

Lan Z, Xu X, Xu W, Li J, Liang Z, Zhang X, Lei M, Zhao C

Drug Design, Development and Therapy 2015, 9:3377-3391

Published Date: 30 June 2015

Dose-dependent effects of atorvastatin on myocardial infarction

Barbarash O, Gruzdeva O, Uchasova E, Belik E, Dyleva Y, Karetnikova V

Drug Design, Development and Therapy 2015, 9:3361-3368

Published Date: 29 June 2015

The role of Gliadel wafers in the treatment of newly diagnosed GBM: a meta-analysis

Xing WK, Shao C, Qi ZY, Yang C, Wang Z

Drug Design, Development and Therapy 2015, 9:3341-3348

Published Date: 29 June 2015

Enzalutamide for the treatment of metastatic castration-resistant prostate cancer

Rodriguez-Vida A, Galazi M, Rudman S, Chowdhury S, Sternberg CN

Drug Design, Development and Therapy 2015, 9:3325-3339

Published Date: 29 June 2015

Effect of renal impairment on the pharmacokinetics of levomilnacipran following a single oral dose of levomilnacipran extended-release capsule in humans

Chen L, Greenberg WM, Brand-Schieber E, Wangsa J, Periclou A, Ghahramani P

Drug Design, Development and Therapy 2015, 9:3293-3300

Published Date: 25 June 2015

Animal models of polymicrobial pneumonia

Hraiech S, Papazian L, Rolain JM, Bregeon F

Drug Design, Development and Therapy 2015, 9:3279-3292

Published Date: 26 June 2015

Development of biosimilars in an era of oncologic drug shortages

Li E, Subramanian J, Anderson S, Thomas D, McKinley J, Jacobs IA

Drug Design, Development and Therapy 2015, 9:3247-3255

Published Date: 24 June 2015

Sphingosine kinase 1 as an anticancer therapeutic target

Gao Y, Gao F, Chen K, Tian ML, Zhao DL

Drug Design, Development and Therapy 2015, 9:3239-3245

Published Date: 23 June 2015

Simvastatin prevents isoproterenol-induced cardiac hypertrophy through modulation of the JAK/STAT pathway

Al-Rasheed NM, Al-Oteibi MM, Al-Manee RZ, Al-Shareef SA, Al-Rasheed NM, Hasan IH, Mohamad RA, Mahmoud AM

Drug Design, Development and Therapy 2015, 9:3217-3229

Published Date: 23 June 2015

Disposition and metabolism of [14C]-levomilnacipran, a serotonin and norepinephrine reuptake inhibitor, in humans, monkeys, and rats

Brunner V, Maynadier B, Chen L, Roques L, Hude I, Séguier S, Barthe L, Hermann P

Drug Design, Development and Therapy 2015, 9:3199-3215

Published Date: 23 June 2015

Characterization of renal biomarkers for use in clinical trials: effect of preanalytical processing and qualification using samples from subjects with diabetes

Brott DA, Furlong ST, Adler SH, Hainer JW, Arani RB, Pinches M, Rossing P, Chaturvedi N

Drug Design, Development and Therapy 2015, 9:3191-3198

Published Date: 22 June 2015

The impact of lipocalin-type-prostaglandin-D-synthase as a predictor of kidney disease in patients with type 2 diabetes

Bacci MR, Cavallari MR, de Rozier-Alves RM, Alves BCA, Fonseca FLA

Drug Design, Development and Therapy 2015, 9:3179-3182

Published Date: 22 June 2015

Histone demethylase LSD1-mediated repression of GATA-2 is critical for erythroid differentiation

Guo Y, Fu X, Jin Y, Sun J, Liu Y, Huo B, Li X, Hu X

Drug Design, Development and Therapy 2015, 9:3153-3162

Published Date: 19 June 2015

Gamma scintigraphic study of the hydrodynamically balanced matrix tablets of Metformin HCl in rabbits

Razavi M, Karimian H, Yeong CH, Sarji SA, Chung LY, Nyamathulla S, Noordin MI

Drug Design, Development and Therapy 2015, 9:3125-3139

Published Date: 19 June 2015

Insulin administration: present strategies and future directions for a noninvasive (possibly more physiological) delivery

Matteucci E, Giampietro O, Covolan V, Giustarini D, Fanti P, Rossi R

Drug Design, Development and Therapy 2015, 9:3109-3118

Published Date: 17 June 2015

Phase II study of reintroduction of oxaliplatin for advanced colorectal cancer in patients previously treated with oxaliplatin and irinotecan: RE-OPEN study

Suenaga M, Mizunuma N, Matsusaka S, Shinozaki E, Ozaka M, Ogura M, Yamaguchi T

Drug Design, Development and Therapy 2015, 9:3099-3108

Published Date: 16 June 2015

Inhibition of cyclooxygenase-2 prevents intra-abdominal adhesions by decreasing activity of peritoneal fibroblasts

Wei G, Chen X, Wang G, Jia P, Xu Q, Ping G, Wang K, Li X

Drug Design, Development and Therapy 2015, 9:3083-3098

Published Date: 15 June 2015

Profile of evolocumab and its potential in the treatment of hyperlipidemia

Cicero AF, Colletti A, Borghi C

Drug Design, Development and Therapy 2015, 9:3073-3082

Published Date: 15 June 2015

Antibiotic-modifying activity of riachin, a non-cyanogenic cyanoglycoside extracted from Bauhinia pentandra

Farias PAM, Figueredo FG, Lucas AMB, Moura RB, Coutinho HDM, Silva TMS, Martin ALAR, Fonteles MMF

Drug Design, Development and Therapy 2015, 9:3067-3072

Published Date: 15 June 2015

Cardioprotection against ischemia/reperfusion injury by QiShenYiQi Pill® via ameliorate of multiple mitochondrial dysfunctions

Chen JR, Wei J, Wang LY, Zhu Y, Li L, Olunga MA, Gao XM, Fan GW

Drug Design, Development and Therapy 2015, 9:3051-3066

Published Date: 15 June 2015

Efficiency and safety of subconjunctival injection of anti-VEGF agent – bevacizumab – in treating dry eye

Jiang X, Lv H, Qiu W, Liu Z, Li X, Wang W

Drug Design, Development and Therapy 2015, 9:3043-3050

Published Date: 12 June 2015

Effect of database profile variation on drug safety assessment: an analysis of spontaneous adverse event reports of Japanese cases

Nomura K, Takahashi K, Hinomura Y, Kawaguchi G, Matsushita Y, Marui H, Anzai T, Hashiguchi M, Mochizuki M

Drug Design, Development and Therapy 2015, 9:3031-3041

Published Date: 12 June 2015

Oleanolic acid induces mitochondrial-dependent apoptosis and G0/G1 phase arrest in gallbladder cancer cells

Li HF, Wang XA, Xiang SS, Hu YP, Jiang L, Shu YJ, Li ML, Wu XS, Zhang F, Ye YY, Weng H, Bao RF, Cao Y, Lu W, Dong Q, Liu YB

Drug Design, Development and Therapy 2015, 9:3017-3030

Published Date: 12 June 2015

Osteopontin promotes dendritic cell maturation and function in response to HBV antigens

Cui GY, Chen JN, He JQ, Lu C, Wei YF, Wang L, Xu XJ, Li LJ, Uede T, Diao HY

Drug Design, Development and Therapy 2015, 9:3003-3016

Published Date: 12 June 2015

Involvement of NF-κB and HSP70 signaling pathways in the apoptosis of MDA-MB-231 cells induced by a prenylated xanthone compound, α-mangostin, from Cratoxylum arborescens [Corrigendum]

Ibrahim MY, Hashim NM, Mohan S, Abdulla MA, Abdelwahab SI, Kamalidehghan B, Ghaderian M, Dehghan F, Ali LZ, Karimian H, Yahayu M, Ee GCL, Farjam AS, Ali HM

Drug Design, Development and Therapy 2015, 9:3001-3002

Published Date: 12 June 2015

Assessment of hydroxychloroquine maculopathy after cessation of treatment: an optical coherence tomography and multifocal electroretinography study

Moschos MM, Nitoda E, Chatziralli IP, Gatzioufas Z, Koutsandrea C, Kitsos G

Drug Design, Development and Therapy 2015, 9:2993-2999

Published Date: 11 June 2015

Protective effect of galangin in Concanavalin A- induced hepatitis in mice

Luo Q, Zhu L, Ding J, Zhuang X, Xu L, Chen F

Drug Design, Development and Therapy 2015, 9:2983-2992

Published Date: 10 June 2015

Oxidant/antioxidant status, paraoxonase activity, and lipid profile in plasma of ovariectomized rats under the influence of estrogen, estrogen combined with progesterone, and genistein

Agacayak E, Basaranoglu S, Tunc SY, Icen MS, Findik FM, Kaplan I, Evliyaoglu O, Gul T

Drug Design, Development and Therapy 2015, 9:2975-2982

Published Date: 10 June 2015

Immunostimulatory effects of the standardized extract of Tinospora crispa on innate immune responses in Wistar Kyoto rats

Ahmad W, Jantan I, Kumolosasi E, Abbas Bukhari SN

Drug Design, Development and Therapy 2015, 9:2961-2973

Published Date: 10 June 2015

Cissus quadrangularis inhibits IL-1β induced inflammatory responses on chondrocytes and alleviates bone deterioration in osteotomized rats via p38 MAPK signaling

Kanwar JR, Samarasinghe RM, Kumar K, Arya R, Sharma S, Zhou SF, Sasidharan S, Kanwar RK

Drug Design, Development and Therapy 2015, 9:2927-2940

Published Date: 5 June 2015

Small-molecule BH3 mimetic and pan-Bcl-2 inhibitor AT-101 enhances the antitumor efficacy of cisplatin through inhibition of APE1 repair and redox activity in non-small-cell lung cancer

Ren T, Shan J, Li M, Qing Y, Qian C, Wang G, Li Q, Lu G, Li C, Peng Y, Luo H, Zhang S, Yang Y, Cheng Y, Wang D, Zhou SF

Drug Design, Development and Therapy 2015, 9:2887-2910

Published Date: 8 June 2015

Spotlight on pembrolizumab in the treatment of advanced melanoma

Rajakulendran T, Adam DN

Drug Design, Development and Therapy 2015, 9:2883-2886

Published Date: 4 June 2015

Protective effect of Huang Gan formula in 5/6 nephrectomized rats by depressing the Wnt/β-catenin signaling pathway

Mo LQ, Xiao XY, Song SL, Miao H, Liu ST, Guo D, Li X, Bu C, Hou LB, Yang XX

Drug Design, Development and Therapy 2015, 9:2867-2881

Published Date: 3 June 2015

Efficacy of fimasartan/hydrochlorothiazide combination in hypertensive patients inadequately controlled by fimasartan monotherapy

Rhee MY, Baek SH, Kim W, Park CG, Park SW, Oh BH, Kim SH, Kim JJ, Shin JH, Yoo BS, Rim SJ, Ha JW, Doh JH, Ahn Y, Chae JK, Park JB, Kim SK, Kim CH

Drug Design, Development and Therapy 2015, 9:2847-2854

Published Date: 2 June 2015

Cost-effectiveness analysis of lamivudine, telbivudine, and entecavir in treatment of chronic hepatitis B with adefovir dipivoxil resistance

Wang G, Liu Y, Qiu P, Zhou SF, Xu L, Wen P, Wen J, Xiao X

Drug Design, Development and Therapy 2015, 9:2839-2846

Published Date: 2 June 2015

Applications of calixarenes in cancer chemotherapy: facts and perspectives

Yousaf A, Abd Hamid S, Bunnori NM, Ishola AA

Drug Design, Development and Therapy 2015, 9:2831-2838

Published Date: 2 June 2015

Neuroprotective and antioxidant effects of ghrelin in an experimental glaucoma model

Can N, Catak O, Turgut B, Demir T, Ilhan N, Kuloglu T, Ozercan IH

Drug Design, Development and Therapy 2015, 9:2819-2829

Published Date: 2 June 2015

Itraconazole solid dispersion prepared by a supercritical fluid technique: preparation, in vitro characterization, and bioavailability in beagle dogs

Yin X, Daintree LS, Ding S, Ledger DM, Wang B, Zhao W, Qi J, Wu W

Drug Design, Development and Therapy 2015, 9:2801-2810

Published Date: 28 May 2015

Isolation and evaluation of anticancer efficacy of stigmasterol in a mouse model of DMBA-induced skin carcinoma

Ali H, Dixit S, Ali D, Alqahtani SM, Alkahtani S, Alarifi S

Drug Design, Development and Therapy 2015, 9:2793-2800

Published Date: 28 May 2015

Role of sodium tungstate as a potential antiplatelet agent

Fernández-Ruiz R, Pino M, Hurtado B, García de Frutos P, Caballo C, Escolar G, Gomis R, Diaz-Ricart M

Drug Design, Development and Therapy 2015, 9:2777-2786

Published Date: 26 May 2015

Combination therapy of fenofibrate and ursodeoxycholic acid in patients with primary biliary cirrhosis who respond incompletely to UDCA monotherapy: a meta-analysis

Zhang Y, Li S, He L, Wang F, Chen K, Li J, Liu T, Zheng Y, Wang J, Lu W, Zhou Y, Yin Q, Xia Y, Zhou Y, Lu J, Guo C

Drug Design, Development and Therapy 2015, 9:2757-2766

Published Date: 25 May 2015

Antitumor effects of traditional Chinese medicine targeting the cellular apoptotic pathway

Xu HL, Zhao X, Liu XH, Xu PX, Zhang KM, Lin XK

Drug Design, Development and Therapy 2015, 9:2735-2744

Published Date: 21 May 2015

Effects of strontium ranelate on bone formation in the mid-palatal suture after rapid maxillary expansion

Zhao SY, Wang XX, Li N, Chen Y, Su YR, Zhang J

Drug Design, Development and Therapy 2015, 9:2725-2734

Published Date: 21 May 2015

Synthesis and characterization of tumor-targeted copolymer nanocarrier modified by transferrin

Liu R, Wang Y, Li X, Bao W, Xia G, Chen W, Cheng J, Xu Y, Guo L, Chen B

Drug Design, Development and Therapy 2015, 9:2705-2719

Published Date: 22 May 2015

Anti-Warburg effect of rosmarinic acid via miR-155 in gastric cancer cells

Han S, Yang SH, Cai Z, Pan DY, Li Z, Huang ZH, Zhang PS, Zhu HJ, Lei LJ, Wang WW

Drug Design, Development and Therapy 2015, 9:2695-2703

Published Date: 19 May 2015

Impact of JAK2(V617F) mutation status on treatment response to anagrelide in essential thrombocythemia: an observational, hypothesis-generating study

Cascavilla N, De Stefano V, Pane F, Pancrazzi A, Iurlo A, Gobbi M, Palandri F, Specchia G, Liberati AM, D’Adda M, Gaidano G, Fjerza R, Achenbach H, Smith J, Wilde P, Vannucchi AM

Drug Design, Development and Therapy 2015, 9:2687-2694

Published Date: 18 May 2015

The usefulness of ozone treatment in spinal pain

Bocci V, Borrelli E, Zanardi I, Travagli V

Drug Design, Development and Therapy 2015, 9:2677-2685

Published Date: 15 May 2015

A thorough QT study to assess the effects of tbo-filgrastim on cardiac repolarization in healthy subjects

Adar L, Avisar N, Lammerich A, Kleiman RB, Spiegelstein O

Drug Design, Development and Therapy 2015, 9:2653-2662

Published Date: 15 May 2015

Construction of interference vector targeting Ep-CAM gene and its effects on colorectal cancer cell proliferation

Qi Y, Zhou F, Zhang L, Liu L, Xu H, Guo H

Drug Design, Development and Therapy 2015, 9:2647-2652

Published Date: 14 May 2015

A study on the hemocompatibility of dendronized chitosan derivatives in red blood cells

Zhou YF, Li JM, Lu F, Deng JJ, Zhang JH, Fang PJ, Peng XS, Zhou SF

Drug Design, Development and Therapy 2015, 9:2635-2645

Published Date: 14 May 2015

Prevalence of the CYP2D6*10 (C100T), *4 (G1846A), and *14 (G1758A) alleles among Iranians of different ethnicities

Bagheri A, Kamalidehghan B, Haghshenas M, Azadfar P, Akbari L, Sangtarash MH, Vejdandoust F, Ahmadipour F, Meng GY, Houshmand M

Drug Design, Development and Therapy 2015, 9:2627-2634

Published Date: 13 May 2015

A pharmacokinetic comparison of two voriconazole formulations and the effect of CYP2C19 polymorphism on their pharmacokinetic profiles

Chung H, Lee H, Han H, An H, Lim KS, Lee YJ, Cho JY, Yoon SH, Jang IJ, Yu KS

Drug Design, Development and Therapy 2015, 9:2609-2616

Published Date: 13 May 2015

Skin regeneration in deep second-degree scald injuries either by infusion pumping or topical application of recombinant human erythropoietin gel

Giri P, Ebert S, Braumann UD, Kremer M, Giri S, Machens HG, Bader A

Drug Design, Development and Therapy 2015, 9:2565-2579

Published Date: 11 May 2015

Aging-related rotenone-induced neurochemical and behavioral deficits: role of SIRT2 and redox imbalance, and neuroprotection by AK-7

Wang X, Guan Q, Wang M, Yang L, Bai J, Yan Z, Zhang Y, Liu Z

Drug Design, Development and Therapy 2015, 9:2553-2563

Published Date: 7 May 2015

The mazEF toxin–antitoxin system as an attractive target in clinical isolates of Enterococcus faecium and Enterococcus faecalis

Soheili S, Ghafourian S, Sekawi Z, Neela VK, Sadeghifard N, Taherikalani M, Khosravi A, Ramli R, Hamat RA

Drug Design, Development and Therapy 2015, 9:2553-2561

Published Date: 8 May 2015

Sonodynamic effect of hematoporphyrin monomethyl ether on ligature-induced periodontitis in rats

Zhuang DS, Han JL, Bi LJ, Wang YP, Hao YR, Zhou Q, Cao WW

Drug Design, Development and Therapy 2015, 9:2545-2551

Published Date: 6 May 2015

A prospective treatment for sepsis

Shahidi Bonjar MR, Shahidi Bonjar L

Drug Design, Development and Therapy 2015, 9:2537-2543

Published Date: 6 May 2015

Efficacy and safety of different doses of a slow-release corticosteroid implant for macular edema: meta-analysis of randomized controlled trials

Liu QY, He MM, Shi H, Wang QY, Du YR, Liu JL, Ren CD, Xu D, Yu J

Drug Design, Development and Therapy 2015, 9:2527-2535

Published Date: 5 May 2015

Preparation and characterization of genipin-cross-linked silk fibroin/chitosan sustained-release microspheres

Zeng SG, Ye MW, Qiu JQ, Fang W, Rong MD, Guo ZH, Gao WF

Drug Design, Development and Therapy 2015, 9:2501-2514

Published Date: 4 May 2015

Body protective compound-157 enhances alkali-burn wound healing in vivo and promotes proliferation, migration, and angiogenesis in vitro

Huang T, Zhang K, Sun L, Xue X, Zhang C, Shu Z, Mu N, Gu J, Zhang W, Wang Y, Zhang Y, Zhang W

Drug Design, Development and Therapy 2015, 9:2485-2499

Published Date: 30 April 2015

Enhanced anti-inflammatory potential of cinnamate-zinc layered hydroxide in lipopolysaccharide-stimulated RAW 264.7 macrophages

Adewoyin M, Mohsin SMN, Arulselvan P, Hussein MZ, Fakurazi S

Drug Design, Development and Therapy 2015, 9:2475-2484

Published Date: 30 April 2015

Preparation and clinical evaluation of nano-transferosomes for treatment of erectile dysfunction

Ali MFM, Salem HF, Abdelmohsen HF, Attia SK

Drug Design, Development and Therapy 2015, 9:2431-2447

Published Date: 29 April 2015

Pharmacokinetics of mitragynine in man

Trakulsrichai S, Sathirakul K, Auparakkitanon S, Krongvorakul J, Sueajai J, Noumjad N, Sukasem C, Wananukul W

Drug Design, Development and Therapy 2015, 9:2421-2429

Published Date: 29 April 2015

Ultrasound contrast agent loaded with nitric oxide as a theranostic microdevice

Grishenkov D, Gonon A, Weitzberg E, Lundberg JO, Harmark J, Cerroni B, Paradossi G, Janerot-Sjoberg B

Drug Design, Development and Therapy 2015, 9:2409-2419

Published Date: 29 April 2015

Wnt blockers inhibit the proliferation of lung cancer stem cells

Zhang X, Lou Y, Zheng X, Wang H, Sun J, Dong Q, Han B

Drug Design, Development and Therapy 2015, 9:2399-2407

Published Date: 28 April 2015

Development of acquired factor V inhibitor after treatment with ceftazidime: a case report and review of the literature

Cui QY, Shen HS, Wu TQ, Chen HF, Yu ZQ, Wang ZY

Drug Design, Development and Therapy 2015, 9:2395-2398

Published Date: 24 April 2015

Structure–activity exploration of a small-molecule Lipid II inhibitor

Fletcher S, Yu W, Huang J, Kwasny SM, Chauhan J, Opperman TJ, MacKerell Jr AD, de Leeuw EPH

Drug Design, Development and Therapy 2015, 9:2383-2394

Published Date: 24 April 2015

Comparative fasting bioavailability of two clopidogrel formulations in healthy Mediterranean volunteers: an in vitro–in vivo correlation

Zaid AN, Al Ramahi R, Bustami R, Mousa A, Khasawneh S

Drug Design, Development and Therapy 2015, 9:2359-2365

Published Date: 24 April 2015

Critical appraisal of bevacizumab in the treatment of ovarian cancer

Yoshida H, Yabuno A, Fujiwara K

Drug Design, Development and Therapy 2015, 9:2351-2358

Published Date: 28 April 2015

Modifying tetramethyl–nitrophenyl–imidazoline with amino acids: design, synthesis, and 3D-QSAR for improving inflammatory pain therapy

Jiang X, Wang Y, Zhu H, Wang Y, Zhao M, Zhao S, Wu J, Li S, Peng S

Drug Design, Development and Therapy 2015, 9:2329-2342

Published Date: 22 April 2015

A novel glycyrrhetinic acid-modified oxaliplatin liposome for liver-targeting and in vitro/vivo evaluation

Chen J, Jiang H, Wu Y, Li Y, Gao Y

Drug Design, Development and Therapy 2015, 9:2265-2275

Published Date: 20 April 2015

HDACiDB: a database for histone deacetylase inhibitors

Murugan K, Sangeetha S, Ranjitha S, Vimala A, Al-Sohaibani S, Rameshkumar G

Drug Design, Development and Therapy 2015, 9:2257-2264

Published Date: 20 April 2015

Anticancer activity of streptochlorin, a novel antineoplastic agent, in cholangiocarcinoma

Kwak TW, Shin HJ, Jeong YI, Han ME, Oh SO, Kim HJ, Kim DH, Kang DH

Drug Design, Development and Therapy 2015, 9:2201-2214

Published Date: 16 April 2015

Nanoparticle albumin-bound paclitaxel (nab-paclitaxel) as second-line chemotherapy in HER2-negative, taxane-pretreated metastatic breast cancer patients: prospective evaluation of activity, safety, and quality of life

Palumbo R, Sottotetti F, Trifirò G, Piazza E, Ferzi A, Gambaro A, Spinapolice EG, Pozzi E, Tagliaferri B, Teragni C, Bernardo A

Drug Design, Development and Therapy 2015, 9:2189-2199

Published Date: 15 April 2015

Evaluation of combined famotidine with quercetin for the treatment of peptic ulcer: in vivo animal study

Abourehab MA, Khaled KA, Sarhan HA, Ahmed OA

Drug Design, Development and Therapy 2015, 9:2159-2169

Published Date: 13 April 2015

The clinicopathological significance of CDH1 in gastric cancer: a meta-analysis and systematic review

Zeng W, Zhu J, Shan L, Han Z, Aerxiding P, Quhai A, Zeng F, Wang Z, Li H

Drug Design, Development and Therapy 2015, 9:2149-2157

Published Date: 13 April 2015

Paclitaxel attenuates renal interstitial fibroblast activation and interstitial fibrosis by inhibiting STAT3 signaling

Zhang L, Xu X, Yang R, Chen J, Wang S, Yang JQ, Xiang X, He Z, Zhao Y, Dong Z, Zhang D

Drug Design, Development and Therapy 2015, 9:2139-2148

Published Date: 15 April 2015

D-cycloserine augmentation in behavioral therapy for obsessive-compulsive disorder: a meta-analysis

Xia J, Du Y, Han J, Liu G, Wang X

Drug Design, Development and Therapy 2015, 9:2101-2117

Published Date: 21 April 2015

Management of severe sepsis: advances, challenges, and current status

Martin-Loeches I, Levy MM, Artigas A

Drug Design, Development and Therapy 2015, 9:2079-2088

Published Date: 9 April 2015

Impact of potential inappropriate NSAIDs use in chronic pain

Ussai S, Miceli L, Pisa FE, Bednarova R, Giordano A, Della Rocca G, Petelin R

Drug Design, Development and Therapy 2015, 9:2073-2077

Published Date: 9 April 2015

Efficacy and safety of cross-linked hyaluronic acid single injection on osteoarthritis of the knee: a post-marketing phase IV study

Bashaireh K, Naser Z, Hawadya KA, Sorour S, Al-Khateeb RN

Drug Design, Development and Therapy 2015, 9:2063-2072

Published Date: 8 April 2015

Quinoline-based clioquinol and nitroxoline exhibit anticancer activity inducing FoxM1 inhibition in cholangiocarcinoma cells

Chan-on W, Huyen NTB, Songtawee N, Suwanjang W, Prachayasittikul S, Prachayasittikul V

Drug Design, Development and Therapy 2015, 9:2033-2047

Published Date: 8 April 2015

Targeting the hypoxia pathway to treat pancreatic cancer

Erickson LA, Highsmith Jr WE, Fei P, Zhang J

Drug Design, Development and Therapy 2015, 9:2029-2031

Published Date: 8 April 2015

Schisandrin B inhibits cell growth and induces cellular apoptosis and autophagy in mouse hepatocytes and macrophages: implications for its hepatotoxicity

Zhang Y, Zhou ZW, Jin H, Hu C, He ZX, Yu ZL, Ko KM, Yang T, Zhang X, Pan SY, Zhou SF

Drug Design, Development and Therapy 2015, 9:2001-2027

Published Date: 9 April 2015

The effects of amlodipine and platelet rich plasma on bone healing in rats

Atalay Y, Bozkurt MF, Gonul Y, Cakmak O, Agacayak KS, Köse I, Hazman O, Keles H, Turamanlar O, Eroglu M

Drug Design, Development and Therapy 2015, 9:1973-1981

Published Date: 7 April 2015

Gelatin nanoparticle-mediated intranasal delivery of substance P protects against 6-hydroxydopamine-induced apoptosis: an in vitro and in vivo study

Lu CT, Jin RR, Jiang YN, Lin Q, Yu WZ, Mao KL, Tian FR, Zhao YP, zhao YZ

Drug Design, Development and Therapy 2015, 9:1955-1962

Published Date: 7 April 2015

Impact of enzyme replacement therapy and hematopoietic stem cell transplantation in patients with Morquio A syndrome

Tomatsu S, Sawamoto K, Alméciga-Díaz CJ, Shimada T, Bober MB, Chinen Y, Yabe H, Montaño AM, Giugliani R, Kubaski F, Yasuda E, Rodríguez-López A, Espejo-Mojica AJ, Sánchez OF, Mason RW, Barrera LA, Mackenzie WG, Orii T

Drug Design, Development and Therapy 2015, 9:1937-1953

Published Date: 1 April 2015

Comparative efficacy, acceptability, and tolerability of lisdexamfetamine in child and adolescent ADHD: a meta-analysis of randomized, controlled trials

Maneeton B, Maneeton N, Likhitsathian S, Suttajit S, Narkpongphun A, Srisurapanont M, Woottiluk P

Drug Design, Development and Therapy 2015, 9:1927-1936

Published Date: 1 April 2015

Clinical and pharmacological properties of incobotulinumtoxinA and its use in neurological disorders

Jost WH, Benecke R, Hauschke D, Jankovic J, Kaňovský P, Roggenkämper P, Simpson DM, Comella CL

Drug Design, Development and Therapy 2015, 9:1913-1926

Published Date: 1 April 2015

Liraglutide and obesity: a review of the data so far

Ladenheim EE

Drug Design, Development and Therapy 2015, 9:1867-1875

Published Date: 30 March 2015

Pharmacoinformatics approach for investigation of alternative potential hepatitis C virus nonstructural protein 5B inhibitors

Mirza MU, Ghori NUH, Ikram N, Adil AR, Manzoor S

Drug Design, Development and Therapy 2015, 9:1825-1841

Published Date: 27 March 2015

Paracellular permeation-enhancing effect of AT1002 C-terminal amidation in nasal delivery

Song KH, Kim SB, Shim CK, Chung SJ, Kim DD, Rhee SK, Choi GJ, Kim CH, Kim K

Drug Design, Development and Therapy 2015, 9:1815-1823

Published Date: 27 March 2015

Novel nanoliposomal delivery system for polydatin: preparation, characterization, and in vivo evaluation

Wang X, Guan Q, Chen W, Hu X, Li L

Drug Design, Development and Therapy 2015, 9:1805-1813

Published Date: 30 March 2015

Clinical significance of DAPK promoter hypermethylation in lung cancer: a meta-analysis

Li Y, Zhu M, Zhang X, Cheng D, Ma X

Drug Design, Development and Therapy 2015, 9:1785-1796

Published Date: 24 March 2015

Lost expression of ADAMTS5 protein associates with progression and poor prognosis of hepatocellular carcinoma

Li C, Xiong Y, Yang X, Wang L, Zhang S, Dai N, Li M, Ren T, Yang Y, Zhou SF, Gan L, Wang D

Drug Design, Development and Therapy 2015, 9:1773-1783

Published Date: 24 March 2015

Design and prediction of new anticoagulants as a selective Factor IXa inhibitor via three-dimensional quantitative structure-property relationships of amidinobenzothiophene derivatives

Gao JS, Tong XP, Chang YQ, He YX, Mei YD, Tan PH, Guo JL, Liao GC, Xiao GK, Chen WM, Zhou SF, Sun PH

Drug Design, Development and Therapy 2015, 9:1743-1759

Published Date: 23 March 2015

Single and multiple dose pharmacokinetics and tolerability of HX-1171, a novel antioxidant, in healthy volunteers

Kim YH, Choi HY, Lee SH, Lim HS, Miki T, Kang JK, Han KG, Bae KS

Drug Design, Development and Therapy 2015, 9:1735-1742

Published Date: 23 March 2015

Glu-Trp-ONa or its acylated analogue (R-Glu-Trp-ONa) administration enhances the wound healing in the model of chronic skin wounds in rabbits

Shevtsov MA, Smagina LV, Kudriavtceva TA, Petlenko SV, Voronkina IV

Drug Design, Development and Therapy 2015, 9:1717-1727

Published Date: 20 March 2015

Human colon carcinogenesis is associated with increased interleukin-17-driven inflammatory responses

Xie Z, Qu Y, Leng Y, Sun W, Ma S, Wei J, Hu J, Zhang X

Drug Design, Development and Therapy 2015, 9:1679-1689

Published Date: 18 March 2015

Synthesis and biological evaluation of a novel class of curcumin analogs as anti-inflammatory agents for prevention and treatment of sepsis in mouse model

Zhao C, Zhang Y, Zou P, Wang J, He W, Shi D, Li H, Liang G, Yang S

Drug Design, Development and Therapy 2015, 9:1663-1678

Published Date: 18 March 2015

A phase I/II study of biweekly capecitabine and irinotecan plus bevacizumab as second-line chemotherapy in patients with metastatic colorectal cancer

Suenaga M, Mizunuma N, Matsusaka S, Shinozaki E, Ozaka M, Ogura M, Chin K, Yamaguchi T

Drug Design, Development and Therapy 2015, 9:1653-1662

Published Date: 16 March 2015

Plumbagin induces G2/M arrest, apoptosis, and autophagy via p38 MAPK- and PI3K/Akt/mTOR-mediated pathways in human tongue squamous cell carcinoma cells

Pan ST, Qin Y, Zhou ZW, He ZX, Zhang X, Yang T, Yang YX, Wang D, Qiu JX, Zhou SF

Drug Design, Development and Therapy 2015, 9:1601-1626

Published Date: 16 March 2015

The application of click chemistry in the synthesis of agents with anticancer activity

Ma N, Wang Y, Zhao BX, Ye WC, Jiang S

Drug Design, Development and Therapy 2015, 9:1585-1599

Published Date: 12 March 2015

Induction of apoptosis and autophagy via sirtuin1- and PI3K/Akt/mTOR-mediated pathways by plumbagin in human prostate cancer cells

Zhou ZW, Li XX, He ZX, Pan ST, Yang Y, Zhang X, Chow K, Yang T, Qiu JX, Zhou Q, Tan J, Wang D, Zhou SF

Drug Design, Development and Therapy 2015, 9:1511-1554

Published Date: 12 March 2015

Effect of a topical copper indomethacin gel on inflammatory parameters in a rat model of osteoarthritis

Yassin NZ, El-Shenawy SM, Abdel-Rahman RF, Yakoot M, Hassan M, Helmy S

Drug Design, Development and Therapy 2015, 9:1491-1498

Published Date: 12 March 2015

Positive effects on hematological and biochemical imbalances in patients with metastatic breast cancer stage IV, of BP-C1, a new anticancer substance

Lindkær-Jensen S, Larsen S, Habib-Lindkær-Jensen N, Fagertun HE

Drug Design, Development and Therapy 2015, 9:1481-1490

Published Date: 13 March 2015

Neuroprotective therapies for glaucoma

Song W, Huang P, Zhang C

Drug Design, Development and Therapy 2015, 9:1469-1479

Published Date: 11 March 2015

Design, synthesis, and antifungal activities of novel triazole derivatives containing the benzyl group

Xu K, Huang L, Xu Z, Wang Y, Bai G, Wu Q, Wang X, Yu S, Jiang Y

Drug Design, Development and Therapy 2015, 9:1459-1467

Published Date: 11 March 2015

Cryo-ablation improves anti-tumor immunity through recovering tumor educated dendritic cells in tumor-draining lymph nodes

He XZ, Wang QF, Han S, Wang HQ, Ye YY, Zhu ZY, Zhang SZ

Drug Design, Development and Therapy 2015, 9:1449-1458

Published Date: 10 March 2015

Improved corneal bioavailability of ofloxacin: biodegradable microsphere-loaded ion-activated in situ gel delivery system

Sayed EG, Hussein AK, Khaled KA, Ahmed OAA

Drug Design, Development and Therapy 2015, 9:1427-1435

Published Date: 10 March 2015

Single dose pharmacokinetics of the novel transdermal donepezil patch in healthy volunteers

Kim YH, Choi HY, Lim HS, Lee SH, Jeon HS, Hong D, Kim SS, Choi YK, Bae KS

Drug Design, Development and Therapy 2015, 9:1419-1426

Published Date: 10 March 2015

In vivo antitumor and antimetastatic effects of flavokawain B in 4T1 breast cancer cell-challenged mice

Abu N, Mohamad NE, Yeap SK, Lim KL, Akhtar MN, Zulfadli AJ, Beh BK, Abdullah MP, Omar AR, Alitheen NB

Drug Design, Development and Therapy 2015, 9:1401-1417

Published Date: 6 March 2015

Development and optimization of carvedilol orodispersible tablets: enhancement of pharmacokinetic parameters in rabbits

Aljimaee YH, El-Helw AM, Ahmed OA, El-Say KM

Drug Design, Development and Therapy 2015, 9:1379-1392

Published Date: 5 March 2015

Evaluation of cationic polyamidoamine dendrimers’ dermal toxicity in the rat skin model

Winnicka K, Wroblewska M, Sosnowska K, Car H, Kasacka I

Drug Design, Development and Therapy 2015, 9:1367-1377

Published Date: 5 March 2015

Development and in vitro characterization of drug delivery system of rifapentine for osteoarticular tuberculosis

Wu J, Zuo Y, Hu YJ, Wang J, Li JD, Qiao B, Jiang DM

Drug Design, Development and Therapy 2015, 9:1359-1366

Published Date: 5 March 2015

Clinicopathological significance of CXCR4 in non-small cell lung cancer

Zhou X, He L, Hou G, Jiang B, Wang Y, Zhao L

Drug Design, Development and Therapy 2015, 9:1349-1358

Published Date: 5 March 2015

The effect of ethanol sclerotherapy of 5 minutes duration on cyst diameter and rat ovarian tissue in simple ovarian cysts

Şimşek M, Kuloğlu T, Pala Ş, Boztosun A, Can B, Atilgan R

Drug Design, Development and Therapy 2015, 9:1341-1347

Published Date: 5 March 2015

Profile of atacicept and its potential in the treatment of systemic lupus erythematosus

Cogollo E, Silva MA, Isenberg D

Drug Design, Development and Therapy 2015, 9:1331-1339

Published Date: 5 March 2015

Antitumor activity of SA12, a novel peptide, on SKBr-3 breast cancer cells via the mitochondrial apoptosis pathway

Yang L, Cui Y, Shen J, Lin F, Wang X, Long M, Wei J, Zhang H

Drug Design, Development and Therapy 2015, 9:1319-1330

Published Date: 2 March 2015

In vitro and in vivo anti-angiogenic activity of girinimbine isolated from Murraya koenigii

Iman V, Karimian H, Mohan S, Hobani YH, Noordin MI, Mustafa MR, Noor SM

Drug Design, Development and Therapy 2015, 9:1281-1292

Published Date: 3 March 2015

Antitumoral materials with regenerative function obtained using a layer-by-layer technique

Ficai D, Sonmez M, Albu MG, Mihaiescu DE, Ficai A, Bleotu C

Drug Design, Development and Therapy 2015, 9:1269-1279

Published Date: 2 March 2015

Noncoding RNAs as potential biomarkers to predict the outcome in pancreatic cancer

Jin K, Luo G, Xiao Z, Liu Z, Liu C, Ji S, Xu J, Liu L, Long J, Ni Q, Yu X

Drug Design, Development and Therapy 2015, 9:1247-1255

Published Date: 26 February 2015

Pharmacokinetic-pharmacodynamic analysis to evaluate the effect of moxifloxacin on QT interval prolongation in healthy Korean male subjects

Hong T, Han S, Lee J, Jeon S, Park GJ, Park WS, Lim KS, Chung JY, Yu KS, Yim DS

Drug Design, Development and Therapy 2015, 9:1233-1245

Published Date: 26 February 2015

Advantageous effects of immunosuppression with tacrolimus in comparison with cyclosporine A regarding renal function in patients after heart transplantation

Helmschrott M, Rivinius R, Ruhparwar A, Schmack B, Erbel C, Gleissner CA, Akhavanpoor M, Frankenstein L, Ehlermann P, Bruckner T, Katus HA, Doesch AO

Drug Design, Development and Therapy 2015, 9:1217-1224

Published Date: 24 February 2015

Pharmacokinetic interaction between udenafil and dapoxetine: a randomized, open-labeled crossover study in healthy male volunteers

Kim YH, Choi HY, Lee SH, Jeon HS, Lim HS, Bahng MY, Bae KS

Drug Design, Development and Therapy 2015, 9:1209-1216

Published Date: 23 February 2015

Koenimbin, a natural dietary compound of Murraya koenigii (L) Spreng: inhibition of MCF7 breast cancer cells and targeting of derived MCF7 breast cancer stem cells (CD44+/CD24-/low): an in vitro study

Ahmadipour F, Noordin MI, Mohan S, Arya A, Paydar M, Looi CY, Keong YS, Siyamak EN, Fani S, Firoozi M, Yong CL, Sukari MA, Kamalidehghan B

Drug Design, Development and Therapy 2015, 9:1193-1208

Published Date: 24 February 2015

The pan-inhibitor of Aurora kinases danusertib induces apoptosis and autophagy and suppresses epithelial-to-mesenchymal transition in human breast cancer cells

Li JP, Yang YX, Liu QL, Zhou ZW, Pan ST, He ZX, Zhang X, Yang T, Pan SY, Duan W, He SM, Chen XW, Qiu JX, Zhou SF

Drug Design, Development and Therapy 2015, 9:1027-1062

Published Date: 17 February 2015

Bardoxolone methyl induces apoptosis and autophagy and inhibits epithelial-to-mesenchymal transition and stemness in esophageal squamous cancer cells

Wang YY, Yang YX, Zhao R, Pan ST, Zhe H, He ZX, Duan W, Zhang X, Yang TX, Qiu JX, Zhou SF

Drug Design, Development and Therapy 2015, 9:993-1026

Published Date: 17 February 2015

Synthesis of an anthraquinone derivative (DHAQC) and its effect on induction of G2/M arrest and apoptosis in breast cancer MCF-7 cell line

Yeap SK, Akhtar MN, Lim KL, Abu N, Ho WY, Zareen S, Roohani K, Ky H, Tan SW, Lajis N, Alitheen NB

Drug Design, Development and Therapy 2015, 9:983-992

Published Date: 17 February 2015

1-1-12 one-step wash-in scheme for desflurane low flow anesthesia: performance without nitrous oxide

Sathitkarnmanee T, Tribuddharat S, Nonlhaopol D, Thananun M, Somdee W

Drug Design, Development and Therapy 2015, 9:977-981

Published Date: 17 February 2015

Human mesenchymal stem cells as delivery of osteoprotegerin gene: homing and therapeutic effect for osteosarcoma

Qiao B, Shui W, Cai L, Guo SQ, Jiang DM

Drug Design, Development and Therapy 2015, 9:969-976

Published Date: 17 February 2015

Design, synthesis, and computational studies on dihydropyrimidine scaffolds as potential lipoxygenase inhibitors and cancer chemopreventive agents

Venugopala KN, Govender R, Khedr MA, Venugopala R, Aldhubiab BE, Harsha S, Odhav B

Drug Design, Development and Therapy 2015, 9:911-921

Published Date: 17 February 2015

Upregulation of PD-L1 and APE1 is associated with tumorigenesis and poor prognosis of gastric cancer

Qing Y, Li Q, Ren T, Xia W, Peng Y, Liu GL, Luo H, Yang YX, Dai XY, Zhou SF, Wang D

Drug Design, Development and Therapy 2015, 9:901-909

Published Date: 16 February 2015

Treatment with a herbal formula B401 enhances neuroprotection and angiogenesis in the R6/2 mouse model of Huntington’s disease

Wang SE, Lin CL, Hsu CH, Sheu SJ, Chien CT, Wu CH

Drug Design, Development and Therapy 2015, 9:887-900

Published Date: 16 February 2015

Tazarotene as alternative topical treatment for onychomycosis

Campione E, Paternò EJ, Costanza G, Diluvio L, Carboni I, Marino D, Favalli C, Chimenti S, Bianchi L, Orlandi A

Drug Design, Development and Therapy 2015, 9:879-886

Published Date: 16 February 2015

Anesthetic drug midazolam inhibits cardiac human ether-à-go-go-related gene channels: mode of action

Vonderlin N, Fischer F, Zitron E, Seyler C, Scherer D, Thomas D, Katus HA, Scholz EP,

Drug Design, Development and Therapy 2015, 9:867-877

Published Date: 16 February 2015

Recent advances in combinatorial biosynthesis for drug discovery

Sun H, Liu Z, Zhao H, Ang EL

Drug Design, Development and Therapy 2015, 9:823-833

Published Date: 12 February 2015

Development of a test for recording both visual and auditory reaction times, potentially useful for future studies in patients on opioids therapy

Miceli L, Bednarova R, Rizzardo A, Samogin V, Della Rocca G

Drug Design, Development and Therapy 2015, 9:817-822

Published Date: 12 February 2015

Borreliacidal activity of Borrelia metal transporter A (BmtA) binding small molecules by manganese transport inhibition

Wagh D, Pothineni VR, Inayathullah M, Liu S, Kim KM, Rajadas J

Drug Design, Development and Therapy 2015, 9:805-816

Published Date: 10 February 2015

Clinical utility of eslicarbazepine: current evidence

Zaccara G, Giovannelli F, Cincotta M, Carelli A, Verrotti A

Drug Design, Development and Therapy 2015, 9:781-789

Published Date: 10 February 2015

Effect and mechanism of fluoxetine on electrophysiology in vivo in a rat model of postmyocardial infarction depression

Liang J, Yuan X, Shi S, Wang F, Chen Y, Qu C, Chen J, Hu D, Yang B

Drug Design, Development and Therapy 2015, 9:763-772

Published Date: 10 February 2015

Clinical pharmacokinetics of AZD3199, an inhaled ultra-long-acting β2-adrenoreceptor agonist (uLABA)

Bjermer L, Kuna P, Jorup C, Bengtsson T, Rosenborg J

Drug Design, Development and Therapy 2015, 9:753-762

Published Date: 5 February 2015

A pharmacokinetic and pharmacodynamic drug interaction between rosuvastatin and valsartan in healthy subjects

Jung JA, Lee SY, Kim JR, Ko JW, Jang SB, Nam SY, Huh W

Drug Design, Development and Therapy 2015, 9:745-752

Published Date: 2 March 2015

Urine metabolomics in rats after administration of ketamine

Wen C, Zhang M, Ma J, Hu L, Wang X, Lin G

Drug Design, Development and Therapy 2015, 9:717-722

Published Date: 3 February 2015

Steroid for epidural injection in spinal stenosis: a systematic review and meta-analysis

Liu K, Liu PC, Liu R, Wu X, Cai M

Drug Design, Development and Therapy 2015, 9:707-716

Published Date: 30 January 2015

Design and in vivo evaluation of oxycodone once-a-day controlled-release tablets

Kim JY, Lee SH, Park CW, Rhee YS, Kim DW, Park J, Lee M, Seo JW, Park ES

Drug Design, Development and Therapy 2015, 9:695-706

Published Date: 30 January 2015

Profile of delamanid for the treatment of multidrug-resistant tuberculosis

Szumowski JD, Lynch JB

Drug Design, Development and Therapy 2015, 9:677-682

Published Date: 29 January 2015

Apparent histological changes of adipocytes after treatment with CL 316,243, a ß-3-adrenergic receptor agonist

Ghorbani M, Teimourian S, Farzad R, Asl NN

Drug Design, Development and Therapy 2015, 9:669-676

Published Date: 11 February 2015

Antiaging therapy: a prospective hypothesis

Shahidi Bonjar MR, Shahidi Bonjar L

Drug Design, Development and Therapy 2015, 9:663-667

Published Date: 28 January 2015

Organic anion transporter 3- and organic anion transporting polypeptides 1B1- and 1B3-mediated transport of catalposide

Jeong HU, Kwon M, Lee Y, Yoo JS, Shin DH, Song IS, Lee HS

Drug Design, Development and Therapy 2015, 9:643-653

Published Date: 22 January 2015

Alisertib induces cell cycle arrest and autophagy and suppresses epithelial-to-mesenchymal transition involving PI3K/Akt/mTOR and sirtuin 1-mediated signaling pathways in human pancreatic cancer cells

Wang F, Li H, Yan XG, Zhou ZW, Yi ZG, He ZX, Pan ST, Yang YX, Wang ZZ, Zhang X, Yang T, Qiu JX, Zhou SF

Drug Design, Development and Therapy 2015, 9:575-601

Published Date: 17 January 2015

Combination therapy of ursodeoxycholic acid and budesonide for PBC–AIH overlap syndrome: a meta-analysis

Zhang H, Yang J, Zhu R, Zheng Y, Zhou Y, Dai W, Wang F, Chen K, Li J, Wang C, Li S, Liu T, Abudumijiti H, Zhou Z, Wang J, Lu W, Wang J, Xia Y, Zhou Y, Lu J, Guo C

Drug Design, Development and Therapy 2015, 9:567-574

Published Date: 17 January 2015

Plumbagin induces cell cycle arrest and autophagy and suppresses epithelial to mesenchymal transition involving PI3K/Akt/mTOR-mediated pathway in human pancreatic cancer cells

Wang F, Wang Q, Zhou ZW, Yu SN, Pan ST, He ZX, Zhang X, Wang D, Yang YX, Yang T, Sun T, Li M, Qiu JX, Zhou SF

Drug Design, Development and Therapy 2015, 9:537-560

Published Date: 17 January 2015

Rare sugar D-psicose prevents progression and development of diabetes in T2DM model Otsuka Long-Evans Tokushima Fatty rats

Hossain A, Yamaguchi F, Hirose K, Matsunaga T, Sui L, Hirata Y, Noguchi C, Katagi A, Kamitori K, Dong Y, Tsukamoto I, Tokuda M

Drug Design, Development and Therapy 2015, 9:525-535

Published Date: 17 January 2015

HMG-CoA reductase inhibitory activity and phytocomponent investigation of Basella alba leaf extract as a treatment for hypercholesterolemia

Baskaran G, Salvamani S, Ahmad SA, Shaharuddin NA, Pattiram PD, Shukor MY

Drug Design, Development and Therapy 2015, 9:509-517

Published Date: 14 January 2015

Inhibition of mitotic Aurora kinase A by alisertib induces apoptosis and autophagy of human gastric cancer AGS and NCI-N78 cells

Yuan CX, Zhou ZW, Yang YX, He ZX, Zhang X, Wang D, Yang T, Wang NJ, Zhao RJ, Zhou SF

Drug Design, Development and Therapy 2015, 9:487-508

Published Date: 14 January 2015

Alisertib, an Aurora kinase A inhibitor, induces apoptosis and autophagy but inhibits epithelial to mesenchymal transition in human epithelial ovarian cancer cells

Ding YH, Zhou ZW, Ha CF, Zhang XY, Pan ST, He ZX, Edelman JL, Wang D, Yang ZX, Zhang XJ, Duan W, Yang TX, Qiu JX, Zhou SF

Drug Design, Development and Therapy 2015, 9:425-464

Published Date: 9 January 2015

Solid lipid nanoparticles loaded with iron to overcome barriers for treatment of iron deficiency anemia

Hosny KM, Banjar ZM, Hariri AH, Hassan AH

Drug Design, Development and Therapy 2015, 9:313-320

Published Date: 8 January 2015

Sample sizes in dosage investigational clinical trials: a systematic evaluation

Huang JH, Su QM, Yang J, Lv YH, He YC, Chen JC, Xu L, Wang K, Zheng QS

Drug Design, Development and Therapy 2015, 9:305-312

Published Date: 7 January 2015

Vipegitide: a folded peptidomimetic partial antagonist of α2β1 integrin with antiplatelet aggregation activity

Momic T, Katzhendler J, Shai E, Noy E, Senderowitz H, Eble JA, Marcinkiewicz C, Varon D, Lazarovici P

Drug Design, Development and Therapy 2015, 9:291-304

Published Date: 5 January 2015

Nanoparticle formulation by Büchi B-90 Nano Spray Dryer for oral mucoadhesion

Harsha SN, Aldhubiab BE, Nair AB, Alhaider IA, Attimarad M, Venugopala KN, Srinivasan S, Gangadhar N, Asif AH

Drug Design, Development and Therapy 2015, 9:273-282

Published Date: 23 January 2015

Synthesis and characterization of a novel chemically designed (Globo)3–DTPA–KLH antigen

Hajmohammadi M, Siadat SD, Ghorbani M, Shafiee Ardestani M, Teimourian S, Asgari V, Ahangari Cohan R, Hajmohammadi M, Hajmohammadi A, Behzadi R, Rajabnezhad S, Namvar Asl N

Drug Design, Development and Therapy 2015, 9:217-239

Published Date: 22 December 2014

Clinicopathological significance and potential drug target of T-cadherin in NSCLC

Wang Z, Wang B, Guo H, Shi G, Hong X

Drug Design, Development and Therapy 2015, 9:207-216

Published Date: 19 December 2014

A thorough QT study in the context of an uptitration regimen with selexipag, a selective oral prostacyclin receptor agonist

Hoch M, Darpo B, Remenova T, Stoltz R, Zhou M, Kaufmann P, Bruderer S, Dingemanse J

Drug Design, Development and Therapy 2015, 9:175-185

Published Date: 17 December 2014

Clinical effect of a positive surgical margin after hepatectomy on survival of patients with intrahepatic cholangiocarcinoma

Yeh CN, Hsieh FJ, Chiang KC, Chen JS, Yeh TS, Jan YY, Chen MF

Drug Design, Development and Therapy 2015, 9:163-174

Published Date: 17 December 2014

Analysis of malignancies in patients after heart transplantation with subsequent immunosuppressive therapy

Rivinius R, Helmschrott M, Ruhparwar A, Schmack B, Klein B, Erbel C, Gleissner CA, Akhavanpoor M, Frankenstein L, Darche FF, Thomas D, Ehlermann P, Bruckner T, Katus HA, Doesch AO

Drug Design, Development and Therapy 2015, 9:93-102

Published Date: 17 December 2014

An evidence-based update on the pharmacological activities and possible molecular targets of Lycium barbarum polysaccharides

Cheng J, Zhou ZW, Sheng HP, He LJ, Fan XW, He ZX, Sun T, Zhang X, Zhao RJ, Gu L, Cao CH, Zhou SF

Drug Design, Development and Therapy 2015, 9:33-78

Published Date: 17 December 2014

Microemulsion of babassu oil as a natural product to improve human immune system function

Pessoa RS, França EL, Ribeiro EB, Lanes PK, Chaud NG, Moraes LC, Honorio-França AC

Drug Design, Development and Therapy 2015, 9:21-31

Published Date: 16 December 2014