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Drug Design, Development and Therapy
ISSN: 1177-8881
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Archive: Volume 9, 2015
Brivaracetam: review of its pharmacology and potential use as adjunctive therapy in patients with partial onset seizures [Corrigendum]
Mumoli L, Palleria C, Gasparini S, Citraro R, Labate A, Ferlazzo E, Gambardella A, De Sarro G, Russo E
Drug Design, Development and Therapy 2015, 9:6509-6510
Published Date: 18 December 2015
Study of bone-like hydroxyapatite/polyamino acid composite materials for their biological properties and effects on the reconstruction of long bone defects
Yan L, Jiang DM,
Drug Design, Development and Therapy 2015, 9:6497-6508
Published Date: 17 December 2015
Association of systolic blood pressure drop with intravenous administration of itraconazole in children with hemato-oncologic disease
Lee HJ, Lee B, Park JD, Jeong HJ, Choi YH, Ju HY, Hong CR, Lee JW, Kim H, Suh DI, Park KD, Kang HJ, Shin HY, Ahn HS
Drug Design, Development and Therapy 2015, 9:6489-6495
Published Date: 17 December 2015
Effect of caffeic acid phenethyl ester on bone formation in the expanded inter-premaxillary suture
Kazancioglu HO, Aksakalli S, Ezirganli S, Birlik M, Esrefoglu M, Acar AH
Drug Design, Development and Therapy 2015, 9:6483-6488
Published Date: 21 December 2015
Profile of deferasirox for the treatment of patients with non-transfusion-dependent thalassemia syndromes
Ricchi P, Marsella M
Drug Design, Development and Therapy 2015, 9:6475-6482
Published Date: 16 December 2015
Effects of vitamin C treatment on collar-induced intimal thickening
Arun MZ, Üstünes L, Sevin G, Özer E
Drug Design, Development and Therapy 2015, 9:6461-6473
Published Date: 15 December 2015
The study on the preparation and characterization of gene-loaded immunomagnetic albumin nanospheres and their anti-cell proliferative effect combined with magnetic fluid hyperthermia on GLC-82 cells
Zhang H, Hou XX, Lin M, Wang L, Li HB, Yuan CY, Liang C, Zhang J, Zhang DS
Drug Design, Development and Therapy 2015, 9:6445-6460
Published Date: 15 December 2015
Enhanced antitumoral activity of doxorubicin against lung cancer cells using biodegradable poly(butylcyanoacrylate) nanoparticles
Melguizo C, Cabeza L, Prados J, Ortiz R, Caba O, Rama AR, Delgado ÁV, Arias JL
Drug Design, Development and Therapy 2015, 9:6433-6444
Published Date: 14 December 2015
Autophagy facilitates lung adenocarcinoma resistance to cisplatin treatment by activation of AMPK/mTOR signaling pathway
Wu T, Wang MC, Jing L, Liu ZY, Guo H, Liu Y, Bai YY, Cheng YZ, Nan KJ, Liang X
Drug Design, Development and Therapy 2015, 9:6421-6431
Published Date: 14 December 2015
Idiopathic pulmonary fibrosis: current treatment options and critical appraisal of nintedanib
Bonella F, Stowasser S, Wollin L
Drug Design, Development and Therapy 2015, 9:6407-6419
Published Date: 14 December 2015
Phase II trial of docetaxel combined with nedaplatin for patients with recurrent and metastatic nasopharyngeal carcinoma
Peng PJ, Lv BJ, Tang C, Liao H, Lin Z, Liu YM, Wang ZH, Wang SY, Cheng ZB
Drug Design, Development and Therapy 2015, 9:6401-6405
Published Date: 10 December 2015
Identification of covalent active site inhibitors of dengue virus protease
Koh-Stenta X, Joy J, Wang SF, Kwek PZ, Wee JLK, Wan KF, Gayen S, Chen AS, Kang C, Lee MA, Poulsen A, Vasudevan SG, Hill J, Nacro K
Drug Design, Development and Therapy 2015, 9:6389-6399
Published Date: 10 December 2015
Effect of oral N-acetylcysteine on COPD patients with microsatellite polymorphism in the heme oxygenase-1 gene promoter
Zhang JQ, Zhang JQ, Fang LZ, Liu L, Fu WP, Dai LM
Drug Design, Development and Therapy 2015, 9:6379-6387
Published Date: 7 December 2015
Effects of intravitreal injection of netrin-1 in retinal neovascularization of streptozotocin-induced diabetic rats
Yu Y, Zou J, Han Y, Quyang L, He H, Hu P, Shao Y, Tu P
Drug Design, Development and Therapy 2015, 9:6363-6377
Published Date: 7 December 2015
Tanshinone IIA ameliorates dextran sulfate sodium-induced inflammatory bowel disease via the pregnane X receptor
Zhang X, Wang Y, Ma Z, Liang Q, Tang X, Hu D, Tan H, Xiao C, Gao Y
Drug Design, Development and Therapy 2015, 9:6343-6362
Published Date: 7 December 2015
Hypoglycemic effect and mechanism of honokiol on type 2 diabetic mice
Sun J, Fu X, Liu Y, Wang Y, Huo B, Guo Y, Gao X, Li W, Hu X
Drug Design, Development and Therapy 2015, 9:6327-6342
Published Date: 4 December 2015
Green tea extract as a treatment for patients with wild-type transthyretin amyloidosis: an observational study
aus dem Siepen F, Bauer R, Aurich M, Buss SJ, Steen H, Altland K, Katus HA, Kristen AV
Drug Design, Development and Therapy 2015, 9:6319-6325
Published Date: 4 December 2015
Ginkgo biloba extract mitigates liver fibrosis and apoptosis by regulating p38 MAPK, NF-κB/IκBα, and Bcl-2/Bax signaling
Wang YY, Wang R, Wang YJ, Peng RQ, Wu Y, Yuan YF
Drug Design, Development and Therapy 2015, 9:6303-6317
Published Date: 3 December 2015
Synthetic biology for pharmaceutical drug discovery
Trosset JY, Carbonell P
Drug Design, Development and Therapy 2015, 9:6285-6302
Published Date: 3 December 2015
Sulodexide therapy for the treatment of diabetic nephropathy, a meta-analysis and literature review
Li R, Xing J, Mu XJ, Wang H, Zhang L, Zhao Y, Zhang Y
Drug Design, Development and Therapy 2015, 9:6275-6283
Published Date: 3 December 2015
Xiaokeping mixture inhibits diabetic nephropathy in streptozotocin-induced rats through blocking TGF-β1/Smad7 signaling
Xin C, Xia Z, Jiang C, Lin M, Li G
Drug Design, Development and Therapy 2015, 9:6269-6274
Published Date: 30 November 2015
Enzymatic vitreolysis with recombinant tissue plasminogen activator for vitreomacular traction
Raczyńska D, Lipowski P, Zorena K, Skorek A, Glasner P
Drug Design, Development and Therapy 2015, 9:6259-6268
Published Date: 27 November 2015
Timosaponin B-II ameliorates diabetic nephropathy via TXNI P, mTOR, and NF-κB signaling pathways in alloxan-induced mice
Yuan YL, Guo CR, Cui LL, Ruan SX, Zhang CF, Ji D, Yang ZL, Li F
Drug Design, Development and Therapy 2015, 9:6247-6258
Published Date: 27 November 2015
The antiplasmodial and spleen protective role of crude Indigofera oblongifolia leaf extract traditionally used in the treatment of malaria in Saudi Arabia
Dkhil MA, Lubbad MY, Al-Shaebi EM, Delic D, Al-Quraishy S
Drug Design, Development and Therapy 2015, 9:6235-6246
Published Date: 25 November 2015
Hyaluronic acid abrogates ethanol-dependent inhibition of collagen biosynthesis in cultured human fibroblasts
Donejko M, Przylipiak A, Rysiak E, Miltyk W, Galicka E, Przylipiak J, Zaręba I, Surazynski A
Drug Design, Development and Therapy 2015, 9:6225-6233
Published Date: 24 November 2015
Different effects of statins on induction of diabetes mellitus: an experimental study
Zhao W, Zhao SP
Drug Design, Development and Therapy 2015, 9:6211-6223
Published Date: 24 November 2015
Radiotherapy potentiation with weekly cisplatin compared to standard every 3 weeks cisplatin chemotherapy for locoregionally advanced head and neck squamous cell carcinoma
Fayette J, Molin Y, Lavergne E, Montbarbon X, Racadot S, Poupart M, Ramade A, Zrounba P, Ceruse P, Pommier P
Drug Design, Development and Therapy 2015, 9:6203-6210
Published Date: 26 November 2015
Synthesis, structural characterization, and anticancer activity of a monobenzyltin compound against MCF-7 breast cancer cells
Fani S, Kamalidehghan B, Lo KM, Hashim NM, Chow KM, Ahmadipour F
Drug Design, Development and Therapy 2015, 9:6191-6201
Published Date: 23 November 2015
Spotlight on tavaborole for the treatment of onychomycosis
Jinna S, Finch J
Drug Design, Development and Therapy 2015, 9:6185-6190
Published Date: 20 November 2015
Prospective study on nanoparticle albumin-bound paclitaxel in advanced breast cancer: clinical results and biological observations in taxane-pretreated patients
Fabi A, Giannarelli D, Malaguti P, Ferretti G, Vari S, Papaldo P, Nisticò C, Caterino M, De Vita R, Mottolese M, Iacorossi L, Cognetti F
Drug Design, Development and Therapy 2015, 9:6177-6183
Published Date: 20 November 2015
Influence of glucosamine on the bioactivity of insulin delivered subcutaneously and in an oral nanodelivery system
Al-Kurdi ZI, Chowdhry BZ, Leharne SA, Qinna NA, Al Omari MMH, Badwan AA
Drug Design, Development and Therapy 2015, 9:6167-6176
Published Date: 19 November 2015
Protective effects of alginate–chitosan microspheres loaded with alkaloids from Coptis chinensis Franch. and Evodia rutaecarpa (Juss.) Benth. (Zuojin Pill) against ethanol-induced acute gastric mucosal injury in rats
Wang QS, Zhu XN, Jiang HL, Wang GF, Cui YL
Drug Design, Development and Therapy 2015, 9:6151-6165
Published Date: 19 November 2015
Efficacy and safety of a conversion from the original tacrolimus and mycophenolate mofetil to the generics Tacpan® and Mowel® after liver transplantation
Vollmar J, Bellmann MC, Darstein F, Hoppe-Lotichius M, Mittler J, Heise M, Rüttger B, Weyer V, Zimmermann A, Lang H, Galle PR, Zimmermann T
Drug Design, Development and Therapy 2015, 9:6139-6149
Published Date: 17 November 2015
Nanoethosomal transdermal delivery of vardenafil for treatment of erectile dysfunction: optimization, characterization, and in vivo evaluation
Fahmy UA
Drug Design, Development and Therapy 2015, 9:6129-6137
Published Date: 18 November 2015
Alpinetin inhibits lung cancer progression and elevates sensitization drug-resistant lung cancer cells to cis-diammined dichloridoplatium
Wu L, Yang W, Zhang SN, Lu JB
Drug Design, Development and Therapy 2015, 9:6119-6127
Published Date: 16 November 2015
DNAzyme-based probe for circulating microRNA detection in peripheral blood
Shao G, Ji S, Wu A, Liu C, Wang M, Zhang P, Jiao Q, Kang Y
Drug Design, Development and Therapy 2015, 9:6109-6117
Published Date: 16 November 2015
Protective effects of triptolide on retinal ganglion cells in a rat model of chronic glaucoma
Yang F, Wang DM, Wu LL, Li Y
Drug Design, Development and Therapy 2015, 9:6095-6107
Published Date: 16 November 2015
Profile of paritaprevir/ritonavir/ombitasvir plus dasabuvir in the treatment of chronic hepatitis C virus genotype 1 infection
Smith MA, Lim A
Drug Design, Development and Therapy 2015, 9:6083-6094
Published Date: 13 November 2015
Apatinib for molecular targeted therapy in tumor
Zhang H
Drug Design, Development and Therapy 2015, 9:6075-6081
Published Date: 13 November 2015
A single-arm Phase II validation study of preventing oxaliplatin-induced hypersensitivity reactions by dexamethasone: the AVOID trial
Yoshida Y, Hirata K, Matsuoka H, Iwamoto S, Kotaka M, Fujita H, Aisu N, Hoshino S, Kosaka T, Maeda K, Kiyomi F, Yamashita Y
Drug Design, Development and Therapy 2015, 9:6067-6073
Published Date: 12 November 2015
Could the FDA-approved anti-HIV PR inhibitors be promising anticancer agents? An answer from enhanced docking approach and molecular dynamics analyses
Arodola OA, Soliman MES
Drug Design, Development and Therapy 2015, 9:6055-6065
Published Date: 13 November 2015
Attenuation of myocardial fibrosis with curcumin is mediated by modulating expression of angiotensin II AT1/AT2 receptors and ACE2 in rats
Pang XF, Zhang LH, Bai F, Wang NP, Garner RE, McKallip RJ, Zhao ZQ
Drug Design, Development and Therapy 2015, 9:6043-6054
Published Date: 11 November 2015
Profile of suvorexant in the management of insomnia
Sutton EL
Drug Design, Development and Therapy 2015, 9:6035-6042
Published Date: 11 November 2015
The very-rapid and the ultra-rapid virologic response to two treatment options in patients with chronic hepatitis C: an interim report of a prospective randomized comparative effectiveness study
Yakoot M, Abdo AM, Yousry A, Helmy S
Drug Design, Development and Therapy 2015, 9:6027-6033
Published Date: 11 November 2015
6-Gingerol alleviates exaggerated vasoconstriction in diabetic rat aorta through direct vasodilation and nitric oxide generation
Ghareib SA, El-Bassossy HM, Elberry AA, Azhar A, Watson ML, Banjar ZM
Drug Design, Development and Therapy 2015, 9:6019-6026
Published Date: 9 November 2015
Glucose abnormalities in Asian patients with chronic hepatitis C
Bo Q, Orsenigo R, Wang J, Griffel L, Brass C
Drug Design, Development and Therapy 2015, 9:6009-6017
Published Date: 9 November 2015
Use of letrozole and clomiphene citrate combined with gonadotropins in clomiphene-resistant infertile women with polycystic ovary syndrome: a prospective study
Xi W, Liu S, Mao H, Yang Y, Xue X, Lu X
Drug Design, Development and Therapy 2015, 9:6001-6008
Published Date: 11 November 2015
Progesterone regulates the proliferation of breast cancer cells – in vitro evidence
Azeez JM, Sithul H, Hariharan I, Sreekumar S, Prabhakar J, Sreeja S, Pillai MR
Drug Design, Development and Therapy 2015, 9:5987-5999
Published Date: 9 November 2015
Mechanisms underlying the perifocal neuroprotective effect of the Nrf2–ARE signaling pathway after intracranial hemorrhage
Yin XP, Chen ZY, Zhou J, Wu D, Bao B
Drug Design, Development and Therapy 2015, 9:5973-5986
Published Date: 17 November 2015
Phytocompounds and modulatory effects of Anacardium microcarpum (cajui) on antibiotic drugs used in clinical infections
Barbosa-Filho VM, Waczuk EP, Leite NF, Menezes IRA, da Costa JGM, Lacerda SR, Adedara IA, Coutinho HDM, Posser T, Kamdem JP
Drug Design, Development and Therapy 2015, 9:5965-5972
Published Date: 6 November 2015
Lentinus squarrosulus (Mont.) mycelium enhanced antioxidant status in rat model
Mhd Omar NA, Abdullah S, Abdullah N, Kuppusamy UR, Abdulla MA, Sabaratnam V
Drug Design, Development and Therapy 2015, 9:5957-5964
Published Date: 6 November 2015
Tumor-induced VEGF-C overexpression in retroperitoneal lymph nodes in VX2 carcinoma-bearing rabbits
Huang YW, Zhou Y, Lan CY, Wang Y, Feng YL, Luo RZ, Liu JH
Drug Design, Development and Therapy 2015, 9:5949-5956
Published Date: 5 November 2015
Systematic review and meta-analysis: bezafibrate in patients with primary biliary cirrhosis [Erratum]
Yin Q, Li J, Xia Y, Zhang R, Wang J, Lu W, Zhou Y, Zheng Y, Abudumijiti H, Chen R, Chen K, Li S, Liu T, Wang F, Lu J, Zhou Y, Guo C
Drug Design, Development and Therapy 2015, 9:5947-5948
Published Date: 9 November 2015
Bauhinia championii flavone inhibits apoptosis and autophagy via the PI3K/Akt pathway in myocardial ischemia/reperfusion injury in rats
Jian J, Xuan FF, Qin FZ, Huang RB
Drug Design, Development and Therapy 2015, 9:5933-5945
Published Date: 6 November 2015
Efficacy and safety of ifosfamide-based chemotherapy for osteosarcoma: a meta-analysis
Fan XL, Cai GP, Zhu LL, Ding GM
Drug Design, Development and Therapy 2015, 9:5925-5932
Published Date: 4 November 2015
PACE4 regulates apoptosis in human prostate cancer cells via endoplasmic reticulum stress and mitochondrial signaling pathways
Yao Z, Sun B, Hong Q, Yan J, Mu D, Li J, Sheng H, Guo H
Drug Design, Development and Therapy 2015, 9:5911-5923
Published Date: 5 November 2015
Critical appraisal of Timothy grass pollen extract GRAZAX® in the management of allergic rhinitis
Scaparrotta A, Attanasi M, Petrosino MI, Di Filippo P, Di Pillo S, Chiarelli F
Drug Design, Development and Therapy 2015, 9:5897-5909
Published Date: 3 November 2015
In silico approach for the discovery of new PPARγ modulators among plant-derived polyphenols
Encinar JA, Fernández-Ballester G, Galiano-Ibarra V, Micol V
Drug Design, Development and Therapy 2015, 9:5877-5895
Published Date: 4 November 2015
Evaluation of the efficacy and safety of three dosing regimens of agalsidase alfa enzyme replacement therapy was underpowered
Ortiz A, Sanchez-Niño MD
Drug Design, Development and Therapy 2015, 9:5873-5875
Published Date: 2 November 2015
Efficacy and tolerability of oral oxycodone and oxycodone/naloxone combination in opioid-naïve cancer patients: a propensity analysis
Lazzari M, Greco MT, Marcassa C, Finocchi S, Caldarulo C, Corli O
Drug Design, Development and Therapy 2015, 9:5863-5872
Published Date: 2 November 2015
Arsenic sulfide combined with JQ1, chemotherapy agents, or celecoxib inhibit gastric and colon cancer cell growth
Zhang L, Tong Y, Zhang X, Pan M, Chen S
Drug Design, Development and Therapy 2015, 9:5851-5862
Published Date: 30 October 2015
The relevance of piroxicam for the prevention and treatment of nonmelanoma skin cancer and its precursors
Campione E, Paternò EJ, Candi E, Falconi M, Costanza G, Diluvio L, Terrinoni A, Bianchi L, Orlandi A
Drug Design, Development and Therapy 2015, 9:5843-5850
Published Date: 29 October 2015
Prevalence of the rs7903146C>T polymorphism in TCF7L2 gene for prediction of type 2 diabetes risk among Iranians of different ethnicities
Allahdini M, Kamalidehghan B, Akbari L, Azadfar P, Rahmani A, Ahmadipour F, Meng GY, Masserrat A, Houshmand M
Drug Design, Development and Therapy 2015, 9:5835-5841
Published Date: 28 October 2015
Profile of pridopidine and its potential in the treatment of Huntington disease: the evidence to date
Squitieri F, de Yebenes JG
Drug Design, Development and Therapy 2015, 9:5827-5833
Published Date: 28 October 2015
Development of oral dispersible tablets containing prednisolone nanoparticles for the management of pediatric asthma
Chen YD, Liang ZY, Cen YY, Zhang H, Han MG, Tian YQ, Zhang J, Li SJ, Yang DS
Drug Design, Development and Therapy 2015, 9:5815-5825
Published Date: 20 November 2015
Curcuma purpurascens BI. rhizome accelerates rat excisional wound healing: involvement of Hsp70/Bax proteins, antioxidant defense, and angiogenesis activity
Rouhollahi E, Moghadamtousi SZ, Hajiaghaalipour F, Zahedifard M, Tayeby F, Awang K, Abdulla MA, Mohamed Z
Drug Design, Development and Therapy 2015, 9:5805-5813
Published Date: 27 October 2015
Empagliflozin in the treatment of type 2 diabetes: evidence to date
Shubrook JH, Baradar Bokaie B, Adkins SE
Drug Design, Development and Therapy 2015, 9:5793-5803
Published Date: 30 October 2015
Efficacy of trabectedin in advanced soft tissue sarcoma: beyond lipo- and leiomyosarcoma
De Sanctis R, Marrari A, Marchetti S, Mussi C, Balzarini L, Lutman FR, Daolio P, Bastoni S, Bertuzzi AF, Quagliuolo V, Santoro A
Drug Design, Development and Therapy 2015, 9:5785-5791
Published Date: 27 October 2015
Reductive metabolism of oxymatrine is catalyzed by microsomal CYP3A4
Liu W, Shi J, Zhu L, Dong L, Luo F, Zhao M, Wang Y, Hu M, Lu L, Liu Z
Drug Design, Development and Therapy 2015, 9:5771-5783
Published Date: 30 October 2015
Rationale and clinical utility of the darunavir–cobicistat combination in the treatment of HIV/AIDS
Putcharoen O, Do T, Avihingsanon A, Ruxrungtham K
Drug Design, Development and Therapy 2015, 9:5763-5769
Published Date: 23 October 2015
Efficacy of thrombomodulin for acute exacerbation of idiopathic pulmonary fibrosis and nonspecific interstitial pneumonia: a nonrandomized prospective study
Abe M, Tsushima K, Matsumura T, Ishiwata T, Ichimura Y, Ikari J, Terada J, Tada Y, Sakao S, Tanabe N, Tatsumi K
Drug Design, Development and Therapy 2015, 9:5755-5762
Published Date: 23 October 2015
Antibacterial activity and therapeutic efficacy of Fl-PRPRPL-5, a cationic amphiphilic polyproline helix, in a mouse model of staphylococcal skin infection
Thangamani S, Nepal M, Chmielewski J, Seleem MN
Drug Design, Development and Therapy 2015, 9:5749-5754
Published Date: 22 October 2015
Mechanism and pharmacological rescue of berberine-induced hERG channel deficiency
Yan M, Zhang KP, Shi YH, Feng LF, Lv L, Li BX
Drug Design, Development and Therapy 2015, 9:5737-5747
Published Date: 22 October 2015
4-Hydroxyisoleucine ameliorates an insulin resistant-like state in 3T3-L1 adipocytes by regulating TACE/TIMP3 expression
Gao F, Du W, Zafar MI, Shafqat RA, Jian L, Cai Q, Lu FR
Drug Design, Development and Therapy 2015, 9:5727-5736
Published Date: 20 October 2015
Brivaracetam: review of its pharmacology and potential use as adjunctive therapy in patients with partial onset seizures
Mumoli L, Palleria C, Gasparini S, Citraro R, Labate A, Ferlazzo E, Gambardella A, De Sarro G, Russo E
Drug Design, Development and Therapy 2015, 9:5719-5725
Published Date: 19 October 2015
Evaluation of the cardiovascular effects of varenicline in rats
Selçuk EB, Sungu M, Parlakpinar H, Ermiş N, Taslıdere E, Vardı N, Yalçınsoy M, Sagır M, Polat A, Karatas M, Kayhan-Tetik B
Drug Design, Development and Therapy 2015, 9:5705-5717
Published Date: 22 October 2015
Overexpression of PI3K p110α contributes to acquired resistance to MET inhibitor, in MET-amplified SNU-5 gastric xenografts
Ji F, Liu X, Wu Y, Fang X, Huang G
Drug Design, Development and Therapy 2015, 9:5697-5704
Published Date: 19 October 2015
Safety and pharmacokinetics of dicloxacillin in healthy Chinese volunteers following single and multiple oral doses
Wu GL, Zheng YL, Zhou HL, Hu XJ, Liu J, Zhai Y, Zhu MX, Wu LH, Shentu JZ
Drug Design, Development and Therapy 2015, 9:5687-5695
Published Date: 16 October 2015
Bifunctional fused polypeptide inhibits the growth and metastasis of breast cancer
Liang AL, Qian HL, Zhang TT, Zhou N, Wang HJ, Men XT, Qi W, Zhang PP, Fu M, Liang X, Lin C, Liu YJ
Drug Design, Development and Therapy 2015, 9:5671-5686
Published Date: 16 October 2015
The role of taxanes in triple-negative breast cancer: literature review [Corrigendum]
Mustacchi G, De Laurentiis M
Drug Design, Development and Therapy 2015, 9:5669-5670
Published Date: 19 October 2015
Adenoviral delivery of truncated MMP-8 fused with the hepatocyte growth factor mutant 1K1 ameliorates liver cirrhosis and promotes hepatocyte proliferation
Liu JH, Li JB, Fu WW, Tang JC, Feng X, Chen J, Liang YL, Jin RA, Xie AY, Cai XJ
Drug Design, Development and Therapy 2015, 9:5655-5667
Published Date: 16 October 2015
Dacomitinib in lung cancer: a “lost generation” EGFR tyrosine-kinase inhibitor from a bygone era?
Ou SH, Soo RA
Drug Design, Development and Therapy 2015, 9:5641-5653
Published Date: 15 October 2015
Pain relief and improved physical function in knee osteoarthritis patients receiving ongoing hylan G-F 20, a high-molecular-weight hyaluronan, versus other treatment options: data from a large real-world longitudinal cohort in Canada
Petrella RJ, Wakeford C
Drug Design, Development and Therapy 2015, 9:5633-5640
Published Date: 15 October 2015
Development of PPAR-agonist GW0742 as antidiabetic drug: study in animals
Niu HS, Ku PM, Niu CS, Cheng JT, Lee KS
Drug Design, Development and Therapy 2015, 9:5625-5632
Published Date: 14 October 2015
Comment on a meta-analysis comparing hepatic resection or transarterial chemoembolization as initial treatment for hepatocellular carcinoma
Zhong JH, Xiang BD, Li LQ
Drug Design, Development and Therapy 2015, 9:5623-5624
Published Date: 13 October 2015
Paeoniflorin inhibits human glioma cells via STAT3 degradation by the ubiquitin–proteasome pathway
Nie XH, Ou-yang J, Xing Y, Li DY, Dong XY, Liu RE, Xu RX
Drug Design, Development and Therapy 2015, 9:5611-5622
Published Date: 13 October 2015
n-Butanol extract from Folium isatidis inhibits lipopolysaccharide-induced inflammatory cytokine production in macrophages and protects mice against lipopolysaccharide-induced endotoxic shock
Jiang LL, Lu YL, Jin JH, Dong LL, Xu FL, Chen SS, Wang ZY, Liang G, Shan XO
Drug Design, Development and Therapy 2015, 9:5601-5609
Published Date: 12 October 2015
Urinary kallidinogenase for the treatment of cerebral arterial stenosis
Zhao L, Zhao Y, Wan Q, Zhang H
Drug Design, Development and Therapy 2015, 9:5595-5600
Published Date: 13 October 2015
Acquired latent tuberculosis infection in psoriasis patients treated with etanercept in the People’s Republic of China
Li CR, Mao QX, Chen M, Jia WX, Yao X, Feng SY, Jia H, Gong JQ, Yang XY
Drug Design, Development and Therapy 2015, 9:5591-5594
Published Date: 12 October 2015
Arsenic sulfide inhibits cell migration and invasion of gastric cancer in vitro and in vivo
Zhang L, Kim S, Ding W, Tong Y, Zhang X, Pan M, Chen S
Drug Design, Development and Therapy 2015, 9:5579-5590
Published Date: 9 October 2015
Novel dehydroepiandrosterone troche supplementation improves the serum androgen profile of women undergoing in vitro fertilization
Keane KN, Hinchliffe PM, Namdar N, Conceicao JL, Newsholme P, Yovich JL
Drug Design, Development and Therapy 2015, 9:5569-5578
Published Date: 9 October 2015
Design, synthesis, and antitumor evaluation of histone deacetylase inhibitors with L-phenylglycine scaffold
Zhang Y, Li X, Hou J, Huang Y, Xu W
Drug Design, Development and Therapy 2015, 9:5553-5567
Published Date: 8 October 2015
Plumbagin suppresses epithelial to mesenchymal transition and stemness via inhibiting Nrf2-mediated signaling pathway in human tongue squamous cell carcinoma cells
Pan ST, Qin Y, Zhou ZW, He ZX, Zhang X, Yang T, Yang YX, Wang D, Zhou SF, Qiu JX
Drug Design, Development and Therapy 2015, 9:5511-5551
Published Date: 5 October 2015
Neuroprotective potential of ferulic acid in the rotenone model of Parkinson’s disease
Ojha S, Javed H, Azimullah S, Abul Khair SB, Haque ME
Drug Design, Development and Therapy 2015, 9:5499-5510
Published Date: 7 October 2015
Crizotinib as a personalized alternative for targeted anaplastic lymphoma kinase rearrangement in previously treated patients with non-small-cell lung cancer
Guo L, Zhang H, Shao W, Chen B
Drug Design, Development and Therapy 2015, 9:5491-5497
Published Date: 3 October 2015
3-Coumaranone derivatives as inhibitors of monoamine oxidase
Van Dyk AS, Petzer JP, Petzer A, Legoabe LJ
Drug Design, Development and Therapy 2015, 9:5479-5489
Published Date: 3 October 2015
A novel small-molecule inhibitor of HIV-1 entry
Heredia A, Latinovic OS, Barbault F, de Leeuw EPH
Drug Design, Development and Therapy 2015, 9:5469-5478
Published Date: 1 October 2015
Maraviroc: a review of its use in HIV infection and beyond
Woollard SM, Kanmogne GD
Drug Design, Development and Therapy 2015, 9:5447-5468
Published Date: 1 October 2015
The clinicopathological significance and drug target potential of FHIT in breast cancer, a meta-analysis and literature review
Su Y, Wang X, Li J, Xu J, Xu L
Drug Design, Development and Therapy 2015, 9:5439-5445
Published Date: 1 October 2015
A proposal for an individualized pharmacogenetic-guided isoniazid dosage regimen for patients with tuberculosis
Jung JA, Kim TE, Lee H, Jeong BH, Park HY, Jeon K, Kwon OJ, Ko JW, Choi R, Woo HI, Koh WJ, Lee SY
Drug Design, Development and Therapy 2015, 9:5433-5438
Published Date: 30 September 2015
Decreased expression of the APOA1–APOC3–APOA4 gene cluster is associated with risk of Alzheimer’s disease
Lin Q, Cao Y, Gao J
Drug Design, Development and Therapy 2015, 9:5421-5431
Published Date: 29 September 2015
Systematic review and meta-analysis: bezafibrate in patients with primary biliary cirrhosis
Yin Q, Li J, Xia Y, Zhang R, Wang J, Lu W, Zhou Y, Zheng Y, Abudumijiti H, Chen R, Chen K, Li S, Liu T, Wang F, Lu J, Zhou Y, Guo C
Drug Design, Development and Therapy 2015, 9:5407-5419
Published Date: 30 September 2015
Intravitreal anti-VEGF injections for treating wet age-related macular degeneration: a systematic review and meta-analysis
Ba J, Peng RS, Xu D, Li YH, Shi H, Wang QY, Yu J
Drug Design, Development and Therapy 2015, 9:5397-5405
Published Date: 28 September 2015
Ghrelin reduces liver impairment in a model of concanavalin A-induced acute hepatitis in mice
Mao YQ, Wang JB, Yu FJ, Cheng J, Li HQ, Guo CY, Fan XM
Drug Design, Development and Therapy 2015, 9:5385-5396
Published Date: 28 September 2015
Collagenase IV plays an important role in regulating hair cycle by inducing VEGF, IGF-1, and TGF-β expression
Hou C, Miao Y, Wang J, Wang X, Chen CY, Hu ZQ
Drug Design, Development and Therapy 2015, 9:5373-5383
Published Date: 25 September 2015
Utilization of cytogenetic biomarkers as a tool for assessment of radiation injury and evaluation of radiomodulatory effects of various medicinal plants – a review
Samarth RM, Samarth M, Matsumoto Y
Drug Design, Development and Therapy 2015, 9:5355-5372
Published Date: 25 September 2015
Efficacy and safety of a vaginal medicinal product containing three strains of probiotic bacteria: a multicenter, randomized, double-blind, and placebo-controlled trial
Tomusiak A, Strus M, Heczko PB, Adamski P, Stefański G, Mikołajczyk-Cichońska A, Suda-Szczurek M
Drug Design, Development and Therapy 2015, 9:5345-5354
Published Date: 25 September 2015
Effect of curcumin on aging retinal pigment epithelial cells
Zhu W, Wu Y, Meng YF, Wang JY, Xu M, Tao JJ, Lu J
Drug Design, Development and Therapy 2015, 9:5337-5344
Published Date: 25 September 2015
A novel derivative of doxorubicin, AD198, inhibits canine transitional cell carcinoma and osteosarcoma cells in vitro
Rathore K, Cekanova M
Drug Design, Development and Therapy 2015, 9:5323-5335
Published Date: 25 September 2015
Investigation of the bioequivalence of montelukast chewable tablets after a single oral administration using a validated LC-MS/MS method
Zaid AN, Abualhasan MN, Watson DG, Mousa A, Ghazal N, Bustami R
Drug Design, Development and Therapy 2015, 9:5315-5321
Published Date: 23 September 2015
Chamaejasmin B exerts anti-MDR effect in vitro and in vivo via initiating mitochondria-dependant intrinsic apoptosis pathway
Wang YJ, Li Q, Xiao HB, Li YJ, Yang Q, Kan XX, Chen Y, Liu XN, Weng XG, Chen X, Cai WY, Guo Y, Huang HF, Zhu XX
Drug Design, Development and Therapy 2015, 9:5301-5313
Published Date: 22 September 2015
Comparative efficacy, tolerability, and survival outcomes of various radiopharmaceuticals in castration-resistant prostate cancer with bone metastasis: a meta-analysis of randomized controlled trials
Tunio M, Al Asiri M, Al Hadab A, Bayoumi Y
Drug Design, Development and Therapy 2015, 9:5291-5299
Published Date: 21 September 2015
The rapid effects of budesonide plus formoterol in patients with obstructive airway diseases
Bayiz H, Ozkaya S, Dirican A, Ece F
Drug Design, Development and Therapy 2015, 9:5287-5290
Published Date: 21 September 2015
Clinicopathological significance and potential drug target of CDH1 in breast cancer: a meta-analysis and literature review
Huang R, Ding P, Yang F
Drug Design, Development and Therapy 2015, 9:5277-5285
Published Date: 18 September 2015
Improvement of oral bioavailability of lovastatin by using nanostructured lipid carriers
Zhou J, Zhou DX
Drug Design, Development and Therapy 2015, 9:5269-5275
Published Date: 18 September 2015
Clinically significant drug–drug interactions involving opioid analgesics used for pain treatment in patients with cancer: a systematic review
Kotlinska-Lemieszek A, Klepstad P, Haugen DF,
Drug Design, Development and Therapy 2015, 9:5255-5267
Published Date: 16 September 2015
Exposure–outcome analysis in depressed patients treated with paroxetine using population pharmacokinetics
Kim JR, Woo HI, Chun MR, Lim SW, Kim HD, Na HS, Chung MW, Myung W, Lee SY, Kim DK
Drug Design, Development and Therapy 2015, 9:5247-5254
Published Date: 16 September 2015
Cromoglycate, not ketotifen, ameliorated the injured effect of warm ischemia/reperfusion in rat liver: role of mast cell degranulation, oxidative stress, proinflammatory cytokine, and inducible nitric oxide synthase
El-Shitany NA, El-Desoky K
Drug Design, Development and Therapy 2015, 9:5237-5246
Published Date: 16 September 2015
MicroRNA-133b targets glutathione S-transferase π expression to increase ovarian cancer cell sensitivity to chemotherapy drugs
Chen S, Jiao JW, Sun KX, Zong ZH, Zhao Y
Drug Design, Development and Therapy 2015, 9:5225-5235
Published Date: 16 September 2015
Companion diagnostics and molecular imaging-enhanced approaches for oncology clinical trials
Van Heertum RL, Scarimbolo R, Ford R, Berdougo E, O’Neal M
Drug Design, Development and Therapy 2015, 9:5215-5223
Published Date: 11 September 2015
Eliglustat tartrate for the treatment of adults with type 1 Gaucher disease [Corrigendum]
Bennett LL, Turcotte K
Drug Design, Development and Therapy 2015, 9:5213-5214
Published Date: 11 September 2015
Dabigatran etexilate retards the initiation and progression of atherosclerotic lesions and inhibits the expression of oncostatin M in apolipoprotein E-deficient mice
Preusch MR, Ieronimakis N, Wijelath ES, Cabbage S, Ricks J, Bea F, Reyes M, van Ryn J, Rosenfeld ME
Drug Design, Development and Therapy 2015, 9:5203-5211
Published Date: 10 September 2015
Pentoxifylline and electromagnetic field improved bone fracture healing in rats
Atalay Y, Gunes N, Guner MD, Akpolat V, Celik MS, Guner R
Drug Design, Development and Therapy 2015, 9:5195-5201
Published Date: 9 September 2015
Exposure–response model for sibutramine and placebo: suggestion for application to long-term weight-control drug development
Han S, Jeon S, Hong T, Lee J, Bae SH, Park WS, Park G, Youn S, Jang DY, Kim KS, Yim DS
Drug Design, Development and Therapy 2015, 9:5185-5194
Published Date: 9 September 2015
Regulation of bone formation by baicalein via the mTORC1 pathway
Li SF, Tang JJ, Chen J, Zhang P, Wang T, Chen TY, Yan B, Huang B, Wang L, Huang MJ, Zhang ZM, Jin DD
Drug Design, Development and Therapy 2015, 9:5169-5183
Published Date: 9 September 2015
The IL-17A G-197A and IL-17F 7488T/C polymorphisms are associated with increased risk of cancer in Asians: a meta-analysis
Wang H, Zhang Y, Liu Z, Zhang Y, Zhao H, Du S
Drug Design, Development and Therapy 2015, 9:5159-5168
Published Date: 24 September 2015
Icariside II ameliorates diabetic nephropathy in streptozotocin-induced diabetic rats
Tian W, Lei H, Guan R, Xu Y, Li H, Wang L, Yang B, Gao Z, Xin Z
Drug Design, Development and Therapy 2015, 9:5147-5157
Published Date: 7 September 2015
Novel levocetirizine HCl tablets with enhanced palatability: synergistic effect of combining taste modifiers and effervescence technique
Labib GS
Drug Design, Development and Therapy 2015, 9:5135-5146
Published Date: 7 September 2015
Novel synthesizing method of pH-dependent doxorubicin-loaded anti-CD22-labelled drug delivery nanosystem
Sun M, Wang J, Lu Q, Xia G, Zhang Y, Song L, Fang Y
Drug Design, Development and Therapy 2015, 9:5123-5133
Published Date: 7 September 2015
The association of CXCR4 expression with clinicopathological significance and potential drug target in prostate cancer: a meta-analysis and literature review
Chen Q, Zhong T
Drug Design, Development and Therapy 2015, 9:5115-5122
Published Date: 7 September 2015
Anthocyanins inhibit high-glucose-induced cholesterol accumulation and inflammation by activating LXRα pathway in HK-2 cells
Du C, Shi Y, Ren Y, Wu H, Yao F, Wei J, Wu M, Hou Y, Duan H
Drug Design, Development and Therapy 2015, 9:5099-5113
Published Date: 4 September 2015
Distinct prognostic values and potential drug targets of ALDH1 isoenzymes in non-small-cell lung cancer
You Q, Guo H, Xu D
Drug Design, Development and Therapy 2015, 9:5087-5097
Published Date: 3 September 2015
Phase III study of pasireotide long-acting release in patients with metastatic neuroendocrine tumors and carcinoid symptoms refractory to available somatostatin analogues
Wolin EM, Jarzab B, Eriksson B, Walter T, Toumpanakis C, Morse MA, Tomassetti P, Weber MM, Fogelman DR, Ramage J, Poon D, Gadbaw B, Li J, Pasieka JL, Mahamat A, Swahn F, Newell-Price J, Mansoor W, Öberg K
Drug Design, Development and Therapy 2015, 9:5075-5086
Published Date: 3 September 2015
Paeonia lactiflora Pall. protects against ANIT-induced cholestasis by activating Nrf2 via PI3K/Akt signaling pathway
Ma X, Zhao Y, Zhu Y, Chen Z, Wang J, Li R, Chen C, Wei S, Li J, Liu B, Wang R, Li Y, Wang L, Xiao X
Drug Design, Development and Therapy 2015, 9:5061-5074
Published Date: 2 September 2015
Inhibition of HIV-1 by curcumin A, a novel curcumin analog
Kumari N, Kulkarni AA, Lin X, McLean C, Ammosova T, Ivanov A, Hipolito M, Nekhai S, Nwulia E
Drug Design, Development and Therapy 2015, 9:5051-5060
Published Date: 3 September 2015
Pharmacokinetics, pharmacodynamics, and tolerability of LC350189, a novel xanthine oxidase inhibitor, in healthy subjects
Yoon S, Shin D, Lee H, Jang IJ, Yu KS
Drug Design, Development and Therapy 2015, 9:5033-5049
Published Date: 31 August 2015
Bu-Shen-Ning-Xin Decoction ameliorated the osteoporotic phenotype of ovariectomized mice without affecting the serum estrogen concentration or uterus
Wang L, Qiu XM, Gui YY, Xu YP, Gober HJ, Li DJ
Drug Design, Development and Therapy 2015, 9:5019-5031
Published Date: 31 August 2015
Pharmacokinetic and nephroprotective benefits of using Schisandra chinensis extracts in a cyclosporine A-based immune-suppressive regime
Lai Q, Wei JB, Mahmoodurrahman M, Zhang CX, Quan SJ, Li TM, Yu Y
Drug Design, Development and Therapy 2015, 9:4997-5018
Published Date: 28 August 2015
A current review of folate receptor alpha as a potential tumor target in non-small-cell lung cancer
Shi H, Guo J, Li C, Wang Z
Drug Design, Development and Therapy 2015, 9:4989-4996
Published Date: 31 August 2015
Role of chymase in the local renin-angiotensin system in keloids: inhibition of chymase may be an effective therapeutic approach to treat keloids
Wang R, Chen J, Zhang Z, Cen Y
Drug Design, Development and Therapy 2015, 9:4979-4988
Published Date: 28 August 2015
Lipopolysaccharide-induced caveolin-1 phosphorylation-dependent increase in transcellular permeability precedes the increase in paracellular permeability
Wang N, Zhang D, Sun G, Zhang H, You Q, Shao M, Yue Y
Drug Design, Development and Therapy 2015, 9:4965-4977
Published Date: 28 August 2015
CXCR4 in breast cancer: oncogenic role and therapeutic targeting
Xu C, Zhao H, Chen H, Yao Q
Drug Design, Development and Therapy 2015, 9:4953-4964
Published Date: 28 August 2015
Insight into the mechanism of polyphenols on the activity of HMGR by molecular docking
Islam B, Sharma C, Adem A, Aburawi EH, Ojha S
Drug Design, Development and Therapy 2015, 9:4943-4951
Published Date: 28 August 2015
The effect of curcumin and its nanoformulation on adjuvant-induced arthritis in rats
Zheng ZL, Sun YH, Liu ZL, Zhang MQ, Li CQ, Cai H
Drug Design, Development and Therapy 2015, 9:4931-4942
Published Date: 27 August 2015
Immunosuppressive effects of the standardized extract of Phyllanthus amarus on cellular immune responses in Wistar-Kyoto rats
Ilangkovan M, Jantan I, Mesaik MA, Bukhari SNA
Drug Design, Development and Therapy 2015, 9:4917-4930
Published Date: 26 August 2015
Profile of omalizumab in the treatment of chronic spontaneous urticaria
Labrador-Horrillo M, Ferrer M
Drug Design, Development and Therapy 2015, 9:4909-4915
Published Date: 25 August 2015
Met tyrosine kinase inhibitor, PF-2341066, suppresses growth and invasion of nasopharyngeal carcinoma
Zhao Y, Zhang J, Tian Y, Xue C, Hu Z, Zhang L
Drug Design, Development and Therapy 2015, 9:4897-4907
Published Date: 26 August 2015
High-throughput sequencing of 16S rDNA amplicons characterizes bacterial composition in bronchoalveolar lavage fluid in patients with ventilator-associated pneumonia
Yang XJ, Wang YB, Zhou ZW, Wang GW, Wang XH, Liu QF, Zhou SF, Wang ZH
Drug Design, Development and Therapy 2015, 9:4883-4896
Published Date: 24 August 2015
Hydrogen sulfide-releasing naproxen suppresses colon cancer cell growth and inhibits NF-κB signaling
Kodela R, Nath N, Chattopadhyay M, Nesbitt DE, Velázquez-Martínez CA, Kashfi K
Drug Design, Development and Therapy 2015, 9:4873-4882
Published Date: 24 August 2015
Repurposing paclitaxel for the treatment of fibrosis: indication discovery for existing drugs
Chen XW, Duan W, Zhou SF
Drug Design, Development and Therapy 2015, 9:4869-4871
Published Date: 7 September 2015
Blood pyrrole-protein adducts as a diagnostic and prognostic index in pyrrolizidine alkaloid-hepatic sinusoidal obstruction syndrome
Gao H, Ruan JQ, Chen J, Li N, Ke CQ, Ye Y, Lin G, Wang JY
Drug Design, Development and Therapy 2015, 9:4861-4868
Published Date: 25 August 2015
Effects of histamine and its antagonists on murine T-cells and bone marrow-derived dendritic cells
Hu XF, Zafar MI, Gao F
Drug Design, Development and Therapy 2015, 9:4847-4860
Published Date: 21 August 2015
Nonalcoholic steatohepatitis: emerging targeted therapies to optimize treatment options
Milic S, Mikolasevic I, Krznaric-Zrnic I, Stanic M, Poropat G, Stimac D, Vlahovic-Palcevski V, Orlic L
Drug Design, Development and Therapy 2015, 9:4835-4845
Published Date: 20 August 2015
How we make cell therapy in Italy
Montemurro T, Viganò M, Budelli S, Montelatici E, Lavazza C, Marino L, Parazzi V, Lazzari L, Giordano R
Drug Design, Development and Therapy 2015, 9:4825-4834
Published Date: 20 August 2015
Translational challenges of animal models in Chagas disease drug development: a review
Chatelain E, Konar N
Drug Design, Development and Therapy 2015, 9:4807-4823
Published Date: 19 August 2015
Role of short-acting nitroglycerin in the management of ischemic heart disease
Boden WE, Padala SK, Cabral KP, Buschmann IR, Sidhu MS
Drug Design, Development and Therapy 2015, 9:4793-4805
Published Date: 19 August 2015
High glucose inhibits ClC-2 chloride channels and attenuates cell migration of rat keratinocytes
Pan F, Guo R, Cheng W, Chai L, Wang W, Cao C, Li S
Drug Design, Development and Therapy 2015, 9:4779-4791
Published Date: 28 August 2015
Effects of chalcone derivatives on players of the immune system
Lee JS, Bukhari SNA, Fauzi NM
Drug Design, Development and Therapy 2015, 9:4761-4778
Published Date: 19 August 2015
Incidence and risk of hypertension with bevacizumab in non-small-cell lung cancer patients: a meta-analysis of randomized controlled trials
Chen J, Lu Y, Zheng Y
Drug Design, Development and Therapy 2015, 9:4751-4760
Published Date: 18 August 2015
Association between glycemic control and antidiabetic drugs in type 2 diabetes mellitus patients with cardiovascular complications
Huri HZ, Ling DYH, Ahmad WAW
Drug Design, Development and Therapy 2015, 9:4735-4749
Published Date: 18 August 2015
Death receptor and mitochondria-mediated hepatocyte apoptosis underlies liver dysfunction in rats exposed to organic pollutants from drinking water
Yang GH, Zhou ZW, Cen YL, Gui XL, Zeng QB, Ao YX, Li Q, Wang SR, Li J, Zhang AH
Drug Design, Development and Therapy 2015, 9:4719-4733
Published Date: 18 August 2015
Development of telmisartan in the therapy of spinal cord injury: pre-clinical study in rats
Lin CM, Tsai JT, Chang CK, Cheng JT, Lin JW
Drug Design, Development and Therapy 2015, 9:4709-4717
Published Date: 14 August 2015
Paget’s disease of bone: an osteoimmunological disorder?
Numan MS, Amiable N, Brown JP, Michou L
Drug Design, Development and Therapy 2015, 9:4695-4707
Published Date: 14 August 2015
Enhancement of absorption and bioavailability of echinacoside by verapamil or clove oil
Shen JY, Yang XL, Yang ZL, Kou JP, Li F
Drug Design, Development and Therapy 2015, 9:4685-4693
Published Date: 14 August 2015
Treatment with metformin and a dipeptidyl peptidase-4 inhibitor elevates apelin levels in patients with type 2 diabetes mellitus
Fan YJ, Zhang Y, Li XS, Zheng H, Song YP, Zhang N, Shen CF, Fan XF, Ren FD, Shen JY, Ren GG, Yang JL
Drug Design, Development and Therapy 2015, 9:4679-4683
Published Date: 14 August 2015
Lefty-1 alleviates TGF-β1-induced fibroblast–myofibroblast transdifferentiation in NRK-49F cells
Zhang LJ, Zhang J, Xu CG, Zhou XJ, Wang W, Zheng RP, Hu W, Wu P
Drug Design, Development and Therapy 2015, 9:4669-4678
Published Date: 14 August 2015
Epidural injections with or without steroids in managing chronic low back pain secondary to lumbar spinal stenosis: a meta-analysis of 13 randomized controlled trials
Meng H, Fei Q, Wang B, Yang Y, Li D, Li J, Su N
Drug Design, Development and Therapy 2015, 9:4657-4667
Published Date: 13 August 2015
Myofibrotic malformation vessels: unique angiodysplasia toward the progression of hemorrhoidal disease
Li SL, Jing FY, Ma LL, Guo LL, Na F, An SL, Ye Y, Yang JM, Bao M, Kang D, Sun XL, Deng YJ
Drug Design, Development and Therapy 2015, 9:4649-4656
Published Date: 13 August 2015
Eliglustat tartrate for the treatment of adults with type 1 Gaucher disease
Bennett LL, Turcotte K
Drug Design, Development and Therapy 2015, 9:4639-4647
Published Date: 18 August 2015
PTEN insufficiency modulates ER+ breast cancer cell cycle progression and increases cell growth in vitro and in vivo
Chiang KC, Chen HY, Hsu SY, Pang JHS, Wang SY, Hsu JT, Yeh TS, Chen LW, Kuo SF, Sun CC, Lee JM, Yeh CN, Juang HH
Drug Design, Development and Therapy 2015, 9:4631-4638
Published Date: 13 August 2015
Pharmacokinetics and bioavailability study of two ondansetron oral soluble film formulations in fasting healthy male Chinese volunteers
Zhu YB, Zhang Q, Zou JJ, Wan M, Zhao Z, Zhu JR
Drug Design, Development and Therapy 2015, 9:4621-4629
Published Date: 12 August 2015
RGD-modified liposomes enhance efficiency of aclacinomycin A delivery: evaluation of their effect in lung cancer
Feng C, Li X, Dong C, Zhang X, Zhang X, Gao Y
Drug Design, Development and Therapy 2015, 9:4613-4620
Published Date: 11 August 2015
Relaxin inhibits cardiac fibrosis and endothelial–mesenchymal transition via the Notch pathway
Zhou X, Chen X, Cai JJ, Chen LZ, Gong YS, Wang LX, Gao Z, Zhang HQ, Huang WJ, Zhou H
Drug Design, Development and Therapy 2015, 9:4599-4611
Published Date: 11 August 2015
Pooled post hoc analysis of population pharmacokinetics of oxycodone and acetaminophen following a single oral dose of biphasic immediate-release/extended-release oxycodone/acetaminophen tablets
Franke RM, Morton T, Devarakonda K
Drug Design, Development and Therapy 2015, 9:4587-4597
Published Date: 11 August 2015
Therapeutic designed poly (lactic-co-glycolic acid) cylindrical oseltamivir phosphate-loaded implants impede tumor neovascularization, growth and metastasis in mouse model of human pancreatic carcinoma
Hrynyk M, Ellis JP, Haxho F, Allison S, Steele JAM, Abdulkhalek S, Neufeld RJ, Szewczuk MR
Drug Design, Development and Therapy 2015, 9:4573-4586
Published Date: 10 August 2015
Ceftobiprole for the treatment of pneumonia: a European perspective
Liapikou A, Cillóniz C, Torres A
Drug Design, Development and Therapy 2015, 9:4565-4572
Published Date: 18 August 2015
Effects of amoxicillin/clavulanic acid on the pharmacokinetics of valproic acid
Lee SY, Huh W, Jung JA, Yoo HM, Ko JW, Kim JR
Drug Design, Development and Therapy 2015, 9:4559-4563
Published Date: 10 August 2015
Evaluation of trends of drug-prescribing patterns based on WHO prescribing indicators at outpatient departments of four hospitals in southern Ethiopia
Summoro TS, Gidebo KD, Kanche ZZ, Woticha EW
Drug Design, Development and Therapy 2015, 9:4551-4557
Published Date: 10 August 2015
Navigating the chemical space of dipeptidyl peptidase-4 inhibitors
Shoombuatong W, Prachayasittikul V, Anuwongcharoen N, Songtawee N, Monnor T, Prachayasittikul S, Prachayasittikul V, Nantasenamat C
Drug Design, Development and Therapy 2015, 9:4515-4549
Published Date: 10 August 2015
Stepwise design, synthesis, and in vitro antifungal screening of (Z)-substituted-propenoic acid derivatives with potent broad-spectrum antifungal activity
Khedr MA
Drug Design, Development and Therapy 2015, 9:4501-4513
Published Date: 10 August 2015
Clinical development of galunisertib (LY2157299 monohydrate), a small molecule inhibitor of transforming growth factor-beta signaling pathway
Herbertz S, Sawyer JS, Stauber AJ, Gueorguieva I, Driscoll KE, Estrem ST, Cleverly AL, Desaiah D, Guba SC, Benhadji KA, Slapak CA, Lahn MM
Drug Design, Development and Therapy 2015, 9:4479-4499
Published Date: 10 August 2015
The efficacy and safety of panitumumab in the treatment of patients with metastatic colorectal cancer: a meta-analysis from five randomized controlled trials
Liang RF, Zheng LL
Drug Design, Development and Therapy 2015, 9:4471-4478
Published Date: 7 August 2015
Novel targeting of PEGylated liposomes for codelivery of TGF-β1 siRNA and four antitubercular drugs to human macrophages for the treatment of mycobacterial infection: a quantitative proteomic study
Niu NK, Yin JJ, Yang YX, Wang ZL, Zhou ZW, He ZX, Chen XW, Zhang XJ, Duan W, Yang TX, Zhou SF
Drug Design, Development and Therapy 2015, 9:4441-4470
Published Date: 7 August 2015
Transarterial chemoembolization versus hepatic resection in hepatocellular carcinoma treatment: a meta-analysis
Tian X, Dai Y, Wang D, Zhang L, Sui C, Meng F, Jiang S, Liu Y, Jiang Y
Drug Design, Development and Therapy 2015, 9:4431-4440
Published Date: 10 August 2015
High-throughput sequencing of 16S rDNA amplicons characterizes bacterial composition in cerebrospinal fluid samples from patients with purulent meningitis
Liu A, Wang C, Liang Z, Zhou ZW, Wang L, Ma Q, Wang G, Zhou SF, Wang Z
Drug Design, Development and Therapy 2015, 9:4417-4429
Published Date: 7 August 2015
Tongguan capsule ameliorates coronary artery stenosis in a 40-year-old woman
Ma H, Wang L, Huang DZ, Liu GQ, Zhang MZ
Drug Design, Development and Therapy 2015, 9:4413-4416
Published Date: 10 August 2015
High-throughput virtual screening with e-pharmacophore and molecular simulations study in the designing of pancreatic lipase inhibitors
Veeramachaneni GK, Raj KK, Chalasani LM, Bondili JS, Talluri VR
Drug Design, Development and Therapy 2015, 9:4397-4412
Published Date: 6 August 2015
The role of aflibercept in the management of diabetic macular edema
Chang AA, Hong T, Ewe SY, Bahrami B, Broadhead GK
Drug Design, Development and Therapy 2015, 9:4389-4396
Published Date: 6 August 2015
Itraconazole solid dispersion prepared by a supercritical fluid technique: preparation, in vitro characterization, and bioavailability in beagle dogs [Corrigendum]
Yin X, Daintree LS, Ding S, Ledger DM, Wang B, Zhao W, Qi J, Wu W, Han J
Drug Design, Development and Therapy 2015, 9:4387-4388
Published Date: 7 August 2015
Gamma scintigraphic evaluation of floating gastroretentive tablets of metformin HCl using a combination of three natural polymers in rabbits
Razavi M, Karimian H, Yeong CH, Chung LY, Nyamathulla S, Noordin MI
Drug Design, Development and Therapy 2015, 9:4373-4386
Published Date: 6 August 2015
Glycemic control and antidiabetic drugs in type 2 diabetes mellitus patients with renal complications
Huri HZ, Lim LP, Lim SK
Drug Design, Development and Therapy 2015, 9:4355-4371
Published Date: 7 August 2015
The pitfall of the transient, inconsistent anticancer capacity of antiestrogens and the mechanism of apparent antiestrogen resistance
Suba Z
Drug Design, Development and Therapy 2015, 9:4341-4353
Published Date: 6 August 2015
Modeling the longitudinal latent effect of pregabalin on self-reported changes in sleep disturbances in outpatients with generalized anxiety disorder managed in routine clinical practice
Ruiz MA, Álvarez E, Carrasco JL, Olivares JM, Pérez M, Rejas J
Drug Design, Development and Therapy 2015, 9:4329-4340
Published Date: 6 August 2015
Characterization of preclinical in vitro and in vivo pharmacokinetics properties for KBP-7018, a new tyrosine kinase inhibitor candidate for treatment of idiopathic pulmonary fibrosis
Huang Z, Li H, Zhang Q, Tan X, Lu F, Liu H, Li S
Drug Design, Development and Therapy 2015, 9:4319-4328
Published Date: 5 August 2015
The role of taxanes in triple-negative breast cancer: literature review
Mustacchi G, De Laurentiis M
Drug Design, Development and Therapy 2015, 9:4303-4318
Published Date: 5 August 2015
Randomized, open-label, blinded-endpoint, crossover, single-dose study to compare the pharmacodynamics of torasemide-PR 10 mg, torasemide-IR 10 mg, and furosemide-IR 40 mg, in patients with chronic heart failure
Ballester MR, Roig E, Gich I, Puntes M, Delgadillo J, Santos B, Antonijoan RM
Drug Design, Development and Therapy 2015, 9:4291-4302
Published Date: 5 August 2015
Hidden costs of antiretroviral treatment: the public health efficiency of drug packaging
Andreu-Crespo À, Llibre JM, Cardona-Peitx G, Sala-Piñol F, Clotet B, Bonafont-Pujol X
Drug Design, Development and Therapy 2015, 9:4287-4290
Published Date: 5 August 2015
Emerging treatment options to improve cardiovascular outcomes in patients with acute coronary syndrome: focus on losmapimod
Kragholm K, Newby LK, Melloni C
Drug Design, Development and Therapy 2015, 9:4279-4286
Published Date: 5 August 2015
Development of megestrol acetate solid dispersion nanoparticles for enhanced oral delivery by using a supercritical antisolvent process
Ha ES, Kim JS, Baek I, Yoo JW, Jung Y, Moon HR, Kim MS
Drug Design, Development and Therapy 2015, 9:4269-4277
Published Date: 4 August 2015
Design, synthesis, and anti-melanogenic effects of (E)-2-benzoyl-3-(substituted phenyl)acrylonitriles
Yun HY, Kim DH, Son S, Ullah S, Kim SJ, Kim YJ, Yoo JW, Jung YJ, Chun P, Moon HR
Drug Design, Development and Therapy 2015, 9:4259-4268
Published Date: 4 August 2015
Colon-targeted delivery of piceatannol enhances anti-colitic effects of the natural product: potential molecular mechanisms for therapeutic enhancement
Yum S, Jeong S, Lee S, Nam J, Kim W, Yoo JW, Kim MS, Lee BL, Jung Y
Drug Design, Development and Therapy 2015, 9:4247-4258
Published Date: 4 August 2015
Advances in cancer pain from bone metastasis
Zhu XC, Zhang JL, Ge CT, Yu YY, Wang P, Yuan TF, Fu CY
Drug Design, Development and Therapy 2015, 9:4239-4245
Published Date: 18 August 2015
Evaluation of glycine-bearing celecoxib derivatives as a colon-specific mutual prodrug acting on nuclear factor-κB, an anti-inflammatory target
Lee S, Lee Y, Kim W, Nam J, Jeong S, Yoo JW, Kim MS, Moon HR, Jung Y
Drug Design, Development and Therapy 2015, 9:4227-4237
Published Date: 7 August 2015
The first clinical experience on efficacy of topical flutamide on melasma compared with topical hydroquinone: a randomized clinical trial
Adalatkhah H, Sadeghi-Bazargani H
Drug Design, Development and Therapy 2015, 9:4219-4225
Published Date: 4 August 2015
Characterization of cubosomes as a targeted and sustained transdermal delivery system for capsaicin
Peng X, Zhou Y, Han K, Qin L, Dian L, Li G, Pan X, Wu C
Drug Design, Development and Therapy 2015, 9:4209-4218
Published Date: 3 August 2015
Antihypercholesterolemic and antioxidant efficacies of zerumbone on the formation, development, and establishment of atherosclerosis in cholesterol-fed rabbits
Hemn HO, Noordin MM, Rahman HS, Hazilawati H, Zuki A, Chartrand MS
Drug Design, Development and Therapy 2015, 9:4173-4208
Published Date: 3 August 2015
CTGF siRNA ameliorates tubular cell apoptosis and tubulointerstitial fibrosis in obstructed mouse kidneys in a Sirt1-independent manner
Ren Y, Du C, Yan L, Wei J, Wu H, Shi Y, Duan H
Drug Design, Development and Therapy 2015, 9:4155-4171
Published Date: 31 July 2015
Understanding the cross-resistance of oseltamivir to H1N1 and H5N1 influenza A neuraminidase mutations using multidimensional computational analyses
Singh A, Soliman ME
Drug Design, Development and Therapy 2015, 9:4137-4154
Published Date: 31 July 2015
Comparison of the pharmacokinetics and tolerability of HCP1004 (a fixed-dose combination of naproxen and esomeprazole strontium) and VIMOVO® (a marketed fixed-dose combination of naproxen and esomeprazole magnesium) in healthy volunteers
Choi YJ, Han HK, Shin D, Lim KS, Yu KS
Drug Design, Development and Therapy 2015, 9:4127-4135
Published Date: 31 July 2015
Nutrigenomic effects of edible bird’s nest on insulin signaling in ovariectomized rats
Hou ZP, Imam MU, Ismail M, Ooi DJ, Ideris A, Mahmud R
Drug Design, Development and Therapy 2015, 9:4115-4125
Published Date: 14 August 2015
Celecoxib coupled to dextran via a glutamic acid linker yields a polymeric prodrug suitable for colonic delivery
Lee Y, Kim J, Kim W, Nam J, Jeong S, Lee S, Yoo JW, Kim MS, Jung Y
Drug Design, Development and Therapy 2015, 9:4105-4113
Published Date: 30 July 2015
A bioinformatic and mechanistic study elicits the antifibrotic effect of ursolic acid through the attenuation of oxidative stress with the involvement of ERK, PI3K/Akt, and p38 MAPK signaling pathways in human hepatic stellate cells and rat liver
He WH, Shi F, Zhou ZW, Li BM, Zhang KH, Zhang XH, Ouyang CH, Zhou SF, Zhu X
Drug Design, Development and Therapy 2015, 9:3989-4104
Published Date: 31 July 2015
20(S)-ginsenoside Rg3 promotes senescence and apoptosis in gallbladder cancer cells via the p53 pathway
Zhang F, Li M, Wu X, Hu Y, Cao Y, Wang X, Xiang S, Li H, Jiang L, Tan Z, Lu W, Weng H, Shu Y, Gong W, Wang X, Zhang Y, Shi W, Dong P, Gu J, Liu Y
Drug Design, Development and Therapy 2015, 9:3969-3987
Published Date: 10 August 2015
Improved oral absorption of cilostazol via sulfonate salt formation with mesylate and besylate
Seo JH, Park JB, Choi WK, Park S, Sung YJ, Oh E, Bae SK
Drug Design, Development and Therapy 2015, 9:3961-3968
Published Date: 30 July 2015
Edible bird’s nest attenuates procoagulation effects of high-fat diet in rats
Yida Z, Imam MU, Ismail M, Ismail N, Hou ZP
Drug Design, Development and Therapy 2015, 9:3951-3959
Published Date: 29 July 2015
A novel in situ gel base of deacetylase gellan gum for sustained ophthalmic drug delivery of ketotifen: in vitro and in vivo evaluation
Zhu L, Ao J, Li P
Drug Design, Development and Therapy 2015, 9:3943-3949
Published Date: 29 July 2015
Combined treatment with olmesartan medoxomil and amlodipine besylate attenuates atherosclerotic lesion progression in a model of advanced atherosclerosis
Sievers P, Uhlmann L, Korkmaz-Icöz S, Fastner C, Bea F, Blessing E, Katus HA, Preusch MR
Drug Design, Development and Therapy 2015, 9:3935-3942
Published Date: 29 July 2015
Gallic acid attenuates dextran sulfate sodium-induced experimental colitis in BALB/c mice
Pandurangan AK, Mohebali N, Norhaizan ME, Looi CY
Drug Design, Development and Therapy 2015, 9:3923-3934
Published Date: 30 July 2015
The chemopreventive potential of Curcuma purpurascens rhizome in reducing azoxymethane-induced aberrant crypt foci in rats
Rouhollahi E, Moghadamtousi SZ, Al-Henhena N, Kunasegaran T, Hasanpourghadi M, Looi CY, Abd Malek SN, Awang K, Abdulla MA, Mohamed Z
Drug Design, Development and Therapy 2015, 9:3911-3922
Published Date: 27 July 2015
Zinc supplementation induces apoptosis and enhances antitumor efficacy of docetaxel in non-small-cell lung cancer
Kocdor H, Ates H, Aydin S, Cehreli R, Soyarat F, Kemanli P, Harmanci D, Cengiz H, Kocdor MA
Drug Design, Development and Therapy 2015, 9:3899-3909
Published Date: 27 July 2015
Ultrasound effects on brain-targeting mannosylated liposomes: in vitro and blood–brain barrier transport investigations
Zidan AS, Aldawsari H
Drug Design, Development and Therapy 2015, 9:3885-3898
Published Date: 24 July 2015
Aterofisiol® in carotid plaque evolution
Amato B, Compagna R, Amato M, Gallelli L, de Franciscis S, Serra R
Drug Design, Development and Therapy 2015, 9:3877-3884
Published Date: 23 July 2015
Dendrimer-coupled sonophoresis-mediated transdermal drug-delivery system for diclofenac
Huang B, Dong WJ, Yang GY, Wang W, Ji CH, Zhou FN
Drug Design, Development and Therapy 2015, 9:3867-3876
Published Date: 23 July 2015
Functional magnetic resonance imaging is a powerful approach to probing the mechanism of action of therapeutic drugs that act on the central nervous system
Zhou SF
Drug Design, Development and Therapy 2015, 9:3863-3865
Published Date: 23 July 2015
The brain signature of paracetamol in healthy volunteers: a double-blind randomized trial
Pickering G, Kastler A, Macian N, Pereira B, Valabrègue R, Lehericy S, Boyer L, Dubray C, Jean B
Drug Design, Development and Therapy 2015, 9:3853-3862
Published Date: 23 July 2015
Navigating into the binding pockets of the HER family protein kinases: discovery of novel EGFR inhibitor as antitumor agent
Liu W, Ning JF, Meng QW, Hu J, Zhao YB, Liu C, Cai L
Drug Design, Development and Therapy 2015, 9:3837-3851
Published Date: 23 July 2015
Effect of lactoferrin protein on red blood cells and macrophages: mechanism of parasite–host interaction
Anand N, Kanwar RK, Dubey ML, Vahishta RK, Sehgal R, Verma AK, Kanwar JR
Drug Design, Development and Therapy 2015, 9:3821-3835
Published Date: 27 July 2015
A new recombinant factor VIII: from genetics to clinical use
Kannicht C, Kohla G, Tiemeyer M, Walter O, Sandberg H
Drug Design, Development and Therapy 2015, 9:3817-3819
Published Date: 23 July 2015
Developments in managing severe chronic pain: role of oxycodone–naloxone extended release
Fanelli G, Fanelli A
Drug Design, Development and Therapy 2015, 9:3811-3816
Published Date: 22 July 2015
Adjunctive therapies to reduce thrombotic events in patients with a history of myocardial infarction: role of vorapaxar
Farag M, Patel H, Gorog DA
Drug Design, Development and Therapy 2015, 9:3801-3809
Published Date: 22 July 2015
Colon-targeted delivery of budesonide using dual pH- and time-dependent polymeric nanoparticles for colitis therapy
Naeem M, Choi MJ, Cao J, Lee Y, Ikram M, Yoon S, Lee J, Moon HR, Kim MS, Jung YJ, Yoo JW
Drug Design, Development and Therapy 2015, 9:3789-3799
Published Date: 21 July 2015
Design, development, drug-likeness, and molecular docking studies of novel piperidin-4-imine derivatives as antitubercular agents
Revathi R, Venkatesha Perumal R, Pai KSR, Arunkumar G, Sriram D, Kini SG
Drug Design, Development and Therapy 2015, 9:3779-3787
Published Date: 21 July 2015
Albumin-bound paclitaxel in solid tumors: clinical development and future directions
Kundranda MN, Niu J
Drug Design, Development and Therapy 2015, 9:3767-3777
Published Date: 24 July 2015
Bu-Shen-Ning-Xin decoction: inhibition of osteoclastogenesis by abrogation of the RANKL-induced NFATc1 and NF-κB signaling pathways via selective estrogen receptor α
Wang L, Qiu XM, Gui YY, Xu YP, Gober HJ, Li DJ
Drug Design, Development and Therapy 2015, 9:3755-3766
Published Date: 21 July 2015
Escherichia coli Nissle 1917 bacterial ghosts retain crucial surface properties and express chlamydial antigen: an imaging study of a delivery system for the ocular surface
Montanaro J, Inic-Kanada A, Ladurner A, Stein E, Belij S, Bintner N, Schlacher S, Schuerer N, Mayr UB, Lubitz W, Leisch N, Barisani-Asenbauer T
Drug Design, Development and Therapy 2015, 9:3741-3754
Published Date: 21 July 2015
Clinicopathological significance of matrix metalloproteinase-7 protein expression in esophageal cancer: a meta-analysis
Miao S, Zhou SY, Han CS, Zhang LN, Sun HB, Yang B
Drug Design, Development and Therapy 2015, 9:3729-3740
Published Date: 20 July 2015
Targeting brain cells with glutathione-modulated nanoliposomes: in vitro and in vivo study
Salem HF, Ahmed SM, Hassaballah AE, Omar MM
Drug Design, Development and Therapy 2015, 9:3705-3727
Published Date: 20 July 2015
Mechanisms underlying probucol-induced hERG-channel deficiency
Shi YQ, Yan CC, Zhang X, Yan M, Liu LR, Geng HZ, Lv L, Li BX
Drug Design, Development and Therapy 2015, 9:3695-3704
Published Date: 20 July 2015
The efficacy and safety of pemetrexed-based doublet therapy compared to pemetrexed alone for the second-line treatment of advanced non-small-cell lung cancer: an updated meta-analysis
Zhong AY, Xiong XL, Shi MH, Xu HJ
Drug Design, Development and Therapy 2015, 9:3685-3693
Published Date: 20 July 2015
Relationship between UGT1A1*6/*28 polymorphisms and severe toxicities in Chinese patients with pancreatic or biliary tract cancer treated with irinotecan-containing regimens
Yang C, Liu Y, Xi WQ, Zhou CF, Jiang JL, Ma T, Ye ZB, Zhang J, Zhu ZG
Drug Design, Development and Therapy 2015, 9:3677-3683
Published Date: 17 July 2015
Treatment of Staphylococcus aureus-induced chronic osteomyelitis with bone-like hydroxyapatite/poly amino acid loaded with rifapentine microspheres
Yan L, Jiang DM, Cao ZD, Wu J, Wang X, Wang ZL, Li YJ, Yi YF
Drug Design, Development and Therapy 2015, 9:3665-3676
Published Date: 16 July 2015
Bacteriophage-based therapy in cystic fibrosis-associated Pseudomonas aeruginosa infections: rationale and current status
Hraiech S, Brégeon F, Rolain JM
Drug Design, Development and Therapy 2015, 9:3653-3663
Published Date: 16 July 2015
Synthesis, antimicrobial and in vitro antitumor activities of a series of 1,2,3-thiadiazole and 1,2,3-selenadiazole derivatives
Mhaidat NM, Al-Smadi M, Al-Momani F, Alzoubi KH, Mansi I, Al-Balas Q
Drug Design, Development and Therapy 2015, 9:3645-3652
Published Date: 16 July 2015
2-acetylphenol analogs as potent reversible monoamine oxidase inhibitors
Legoabe LJ, Petzer A, Petzer JP
Drug Design, Development and Therapy 2015, 9:3635-3644
Published Date: 15 July 2015
A meta-analysis for C-X-C chemokine receptor type 4 as a prognostic marker and potential drug target in hepatocellular carcinoma
Hu F, Miao L, Zhao Y, Xiao YY, Xu Q
Drug Design, Development and Therapy 2015, 9:3625-3633
Published Date: 15 July 2015
Selective oropharyngeal decontamination versus selective digestive decontamination in critically ill patients: a meta-analysis of randomized controlled trials
Zhao D, Song J, Gao X, Gao F, Wu Y, Lu Y, Hou K
Drug Design, Development and Therapy 2015, 9:3617-3624
Published Date: 14 July 2015
Downregulation of miR203 induces overexpression of PIK3CA and predicts poor prognosis of gastric cancer patients
Liang M, Shi B, Liu J, He L, Yi G, Zhou L, Yu G, Zhou X
Drug Design, Development and Therapy 2015, 9:3607-3616
Published Date: 16 July 2015
Depot injectable biodegradable nanoparticles loaded with recombinant human bone morphogenetic protein-2: preparation, characterization, and in vivo evaluation
Hassan AH, Hosny KM, Murshid ZA, Alhadlaq A, Alyamani A, Naguib G
Drug Design, Development and Therapy 2015, 9:3599-3606
Published Date: 13 July 2015
Apparent Km of mitochondria for oxygen computed from Vmax measured in permeabilized muscle fibers is lower in water enriched in oxygen by electrolysis than injection
Zoll J, Bouitbir J, Sirvent P, Klein A, Charton A, Jimenez L, Péronnet FR, Geny B, Richard R
Drug Design, Development and Therapy 2015, 9:3589-3597
Published Date: 13 July 2015
Wound healing: a new perspective on glucosylated tetrahydrocurcumin
Bhaskar Rao A, Prasad E, Deepthi SS, Haritha V, Ramakrishna S, Madhusudan K, Surekha MV, Venkata Rao YSR
Drug Design, Development and Therapy 2015, 9:3579-3588
Published Date: 13 July 2015
Pharmacokinetic comparison of sustained- and immediate-release formulations of cilostazol after multiple oral doses in fed healthy male Korean volunteers
Kim YH, Ghim JL, Jung JA, Cho SH, Choe S, Choi HY, Bae KS, Lim HS
Drug Design, Development and Therapy 2015, 9:3571-3577
Published Date: 9 July 2015
Differential benefit risk assessment of DOACs in the treatment of venous thromboembolism: focus on dabigatran
Leung TS, Law EH
Drug Design, Development and Therapy 2015, 9:3557-3569
Published Date: 9 July 2015
Dolutegravir – a review of the pharmacology, efficacy, and safety in the treatment of HIV
Kandel CE, Walmsley SL
Drug Design, Development and Therapy 2015, 9:3547-3555
Published Date: 7 July 2015
Pancreatic cancer: optimizing treatment options, new, and emerging targeted therapies
Chiorean EG, Coveler AL
Drug Design, Development and Therapy 2015, 9:3529-3545
Published Date: 7 July 2015
Reverse phase protein arrays in signaling pathways: a data integration perspective
Creighton CJ, Huang S
Drug Design, Development and Therapy 2015, 9:3519-3527
Published Date: 7 July 2015
Effect of Clausena excavata Burm. f. (Rutaceae) leaf extract on wound healing and antioxidant activity in rats
Albaayit SFA, Abba Y, Rasedee A, Abdullah N
Drug Design, Development and Therapy 2015, 9:3507-3518
Published Date: 13 July 2015
Investigation of cyclooxygenase and signaling pathways involved in human platelet aggregation mediated by synergistic interaction of various agonists
Khan N, Farooq AD, Sadek B
Drug Design, Development and Therapy 2015, 9:3497-3506
Published Date: 6 July 2015
Phenolic indeno[1,2-b]indoles as ABCG2-selective potent and non-toxic inhibitors stimulating basal ATPase activity
Gozzi GJ, Bouaziz Z, Winter E, Daflon-Yunes N, Honorat M, Guragossian N, Marminon C, Valdameri G, Bollacke A, Guillon J, Pinaud N, Marchivie M, Cadena SM, Jose J, Le Borgne M, Di Pietro A
Drug Design, Development and Therapy 2015, 9:3481-3495
Published Date: 3 July 2015
Adaptive evolution and elucidating the potential inhibitor against schizophrenia to target DAOA (G72) isoforms
Sehgal SA, Mannan S, Kanwal S, Naveed I, Mir A
Drug Design, Development and Therapy 2015, 9:3471-3480
Published Date: 3 July 2015
Selective use of vandetanib in the treatment of thyroid cancer
Fallahi P, Di Bari F, Ferrari SM, Spisni R, Materazzi G, Miccoli P, Benvenga S, Antonelli A
Drug Design, Development and Therapy 2015, 9:3459-3470
Published Date: 3 July 2015
Siltuximab (CNTO 328): a promising option for human malignancies
Chen R, Chen B
Drug Design, Development and Therapy 2015, 9:3455-3458
Published Date: 2 July 2015
Animal models of ischemic stroke and their application in clinical research
Fluri F, Schuhmann MK, Kleinschnitz C
Drug Design, Development and Therapy 2015, 9:3445-3454
Published Date: 2 July 2015
Evaluation of the efficacy and safety of three dosing regimens of agalsidase alfa enzyme replacement therapy in adults with Fabry disease
Goláň L, Goker-Alpan O, Holida M, Kantola I, Klopotowski M, Kuusisto J, Linhart A, Musial J, Nicholls K, Gonzalez-Rodriguez D, Sharma R, Vujkovac B, Chang P, Wijatyk A
Drug Design, Development and Therapy 2015, 9:3435-3444
Published Date: 8 July 2015
Pharmacokinetics, pharmacodynamics, and safety of lesinurad, a selective uric acid reabsorption inhibitor, in healthy adult males
Shen Z, Rowlings C, Kerr B, Hingorani V, Manhard K, Quart B, Yeh LT, Storgard C
Drug Design, Development and Therapy 2015, 9:3423-3434
Published Date: 2 July 2015
Anti-VEGF treatment for myopic choroid neovascularization: from molecular characterization to update on clinical application
Zhang Y, Han Q, Ru Y, Bo Q, Wei RH
Drug Design, Development and Therapy 2015, 9:3413-3421
Published Date: 2 July 2015
Effect of vitamin C on inflammation and metabolic markers in hypertensive and/or diabetic obese adults: a randomized controlled trial
Ellulu MS, Rahmat A, Patimah I, Khaza’ai H, Abed Y
Drug Design, Development and Therapy 2015, 9:3405-3412
Published Date: 1 July 2015
Scientometrics of drug discovery efforts: pain-related molecular targets
Kissin I
Drug Design, Development and Therapy 2015, 9:3393-3404
Published Date: 1 July 2015
Discovery of 3-n-butyl-2,3-dihydro-1H-isoindol-1-one as a potential anti-ischemic stroke agent
Lan Z, Xu X, Xu W, Li J, Liang Z, Zhang X, Lei M, Zhao C
Drug Design, Development and Therapy 2015, 9:3377-3391
Published Date: 30 June 2015
Pirfenidone-loaded liposomes for lung targeting: preparation and in vitro/in vivo evaluation
Meng H, Xu Y
Drug Design, Development and Therapy 2015, 9:3369-3376
Published Date: 30 June 2015
Dose-dependent effects of atorvastatin on myocardial infarction
Barbarash O, Gruzdeva O, Uchasova E, Belik E, Dyleva Y, Karetnikova V
Drug Design, Development and Therapy 2015, 9:3361-3368
Published Date: 29 June 2015
Innovation of natural essential oil-loaded Orabase for local treatment of oral candidiasis
Labib GS, Aldawsari H
Drug Design, Development and Therapy 2015, 9:3349-3359
Published Date: 29 June 2015
The role of Gliadel wafers in the treatment of newly diagnosed GBM: a meta-analysis
Xing WK, Shao C, Qi ZY, Yang C, Wang Z
Drug Design, Development and Therapy 2015, 9:3341-3348
Published Date: 29 June 2015
Enzalutamide for the treatment of metastatic castration-resistant prostate cancer
Rodriguez-Vida A, Galazi M, Rudman S, Chowdhury S, Sternberg CN
Drug Design, Development and Therapy 2015, 9:3325-3339
Published Date: 29 June 2015
Exploration of natural product ingredients as inhibitors of human HMG-CoA reductase through structure-based virtual screening
Lin SH, Huang KJ, Weng CF, Shiuan D
Drug Design, Development and Therapy 2015, 9:3313-3324
Published Date: 26 June 2015
Synergistic antitumor effect of adenovirus armed with Drosophila melanogaster deoxyribonucleoside kinase and nucleoside analogs for human breast carcinoma in vitro and in vivo
Tang M, Zu C, He AN, Wang WQ, Chen B, Zheng XY
Drug Design, Development and Therapy 2015, 9:3301-3312
Published Date: 14 July 2015
Effect of renal impairment on the pharmacokinetics of levomilnacipran following a single oral dose of levomilnacipran extended-release capsule in humans
Chen L, Greenberg WM, Brand-Schieber E, Wangsa J, Periclou A, Ghahramani P
Drug Design, Development and Therapy 2015, 9:3293-3300
Published Date: 25 June 2015
Animal models of polymicrobial pneumonia
Hraiech S, Papazian L, Rolain JM, Bregeon F
Drug Design, Development and Therapy 2015, 9:3279-3292
Published Date: 26 June 2015
A meta-analysis for CXCR4 as a prognostic marker and potential drug target in non-small cell lung cancer
Zhang C, Li J, Han Y, Jiang J
Drug Design, Development and Therapy 2015, 9:3267-3278
Published Date: 24 June 2015
Improving dissolution and oral bioavailability of pranlukast hemihydrate by particle surface modification with surfactants and homogenization
Ha ES, Baek I, Yoo JW, Jung Y, Kim MS
Drug Design, Development and Therapy 2015, 9:3257-3266
Published Date: 24 June 2015
Development of biosimilars in an era of oncologic drug shortages
Li E, Subramanian J, Anderson S, Thomas D, McKinley J, Jacobs IA
Drug Design, Development and Therapy 2015, 9:3247-3255
Published Date: 24 June 2015
Sphingosine kinase 1 as an anticancer therapeutic target
Gao Y, Gao F, Chen K, Tian ML, Zhao DL
Drug Design, Development and Therapy 2015, 9:3239-3245
Published Date: 23 June 2015
Design of a gelatin microparticle-containing self-microemulsifying formulation for enhanced oral bioavailability of dutasteride
Baek I, Ha ES, Yoo JW, Jung Y, Kim MS
Drug Design, Development and Therapy 2015, 9:3231-3238
Published Date: 23 June 2015
Simvastatin prevents isoproterenol-induced cardiac hypertrophy through modulation of the JAK/STAT pathway
Al-Rasheed NM, Al-Oteibi MM, Al-Manee RZ, Al-Shareef SA, Al-Rasheed NM, Hasan IH, Mohamad RA, Mahmoud AM
Drug Design, Development and Therapy 2015, 9:3217-3229
Published Date: 23 June 2015
Disposition and metabolism of [14C]-levomilnacipran, a serotonin and norepinephrine reuptake inhibitor, in humans, monkeys, and rats
Brunner V, Maynadier B, Chen L, Roques L, Hude I, Séguier S, Barthe L, Hermann P
Drug Design, Development and Therapy 2015, 9:3199-3215
Published Date: 23 June 2015
Characterization of renal biomarkers for use in clinical trials: effect of preanalytical processing and qualification using samples from subjects with diabetes
Brott DA, Furlong ST, Adler SH, Hainer JW, Arani RB, Pinches M, Rossing P, Chaturvedi N
Drug Design, Development and Therapy 2015, 9:3191-3198
Published Date: 22 June 2015
Combination of erlotinib and a PARP inhibitor inhibits growth of A2780 tumor xenografts due to increased autophagy
Sui H, Shi C, Yan Z, Li H
Drug Design, Development and Therapy 2015, 9:3183-3190
Published Date: 22 June 2015
The impact of lipocalin-type-prostaglandin-D-synthase as a predictor of kidney disease in patients with type 2 diabetes
Bacci MR, Cavallari MR, de Rozier-Alves RM, Alves BCA, Fonseca FLA
Drug Design, Development and Therapy 2015, 9:3179-3182
Published Date: 22 June 2015
Therapeutic effects of C-28 methyl ester of 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid (CDDO-Me; bardoxolone methyl) on radiation-induced lung inflammation and fibrosis in mice
Wang YY, Zhang CY, Ma YQ, He ZX, Zhe H, Zhou SF
Drug Design, Development and Therapy 2015, 9:3163-3178
Published Date: 22 June 2015
Histone demethylase LSD1-mediated repression of GATA-2 is critical for erythroid differentiation
Guo Y, Fu X, Jin Y, Sun J, Liu Y, Huo B, Li X, Hu X
Drug Design, Development and Therapy 2015, 9:3153-3162
Published Date: 19 June 2015
Custom fractional factorial designs to develop atorvastatin self-nanoemulsifying and nanosuspension delivery systems – enhancement of oral bioavailability
Hashem FM, Al-Sawahli MM, Nasr M, Ahmed OA
Drug Design, Development and Therapy 2015, 9:3141-3152
Published Date: 19 June 2015
Gamma scintigraphic study of the hydrodynamically balanced matrix tablets of Metformin HCl in rabbits
Razavi M, Karimian H, Yeong CH, Sarji SA, Chung LY, Nyamathulla S, Noordin MI
Drug Design, Development and Therapy 2015, 9:3125-3139
Published Date: 19 June 2015
Anticancer activity of Nigella sativa (black seed) and its relationship with the thermal processing and quinone composition of the seed
Agbaria R, Gabarin A, Dahan A, Ben-Shabat S
Drug Design, Development and Therapy 2015, 9:3119-3124
Published Date: 18 June 2015
Insulin administration: present strategies and future directions for a noninvasive (possibly more physiological) delivery
Matteucci E, Giampietro O, Covolan V, Giustarini D, Fanti P, Rossi R
Drug Design, Development and Therapy 2015, 9:3109-3118
Published Date: 17 June 2015
Phase II study of reintroduction of oxaliplatin for advanced colorectal cancer in patients previously treated with oxaliplatin and irinotecan: RE-OPEN study
Suenaga M, Mizunuma N, Matsusaka S, Shinozaki E, Ozaka M, Ogura M, Yamaguchi T
Drug Design, Development and Therapy 2015, 9:3099-3108
Published Date: 16 June 2015
Inhibition of cyclooxygenase-2 prevents intra-abdominal adhesions by decreasing activity of peritoneal fibroblasts
Wei G, Chen X, Wang G, Jia P, Xu Q, Ping G, Wang K, Li X
Drug Design, Development and Therapy 2015, 9:3083-3098
Published Date: 15 June 2015
Profile of evolocumab and its potential in the treatment of hyperlipidemia
Cicero AF, Colletti A, Borghi C
Drug Design, Development and Therapy 2015, 9:3073-3082
Published Date: 15 June 2015
Antibiotic-modifying activity of riachin, a non-cyanogenic cyanoglycoside extracted from Bauhinia pentandra
Farias PAM, Figueredo FG, Lucas AMB, Moura RB, Coutinho HDM, Silva TMS, Martin ALAR, Fonteles MMF
Drug Design, Development and Therapy 2015, 9:3067-3072
Published Date: 15 June 2015
Cardioprotection against ischemia/reperfusion injury by QiShenYiQi Pill® via ameliorate of multiple mitochondrial dysfunctions
Chen JR, Wei J, Wang LY, Zhu Y, Li L, Olunga MA, Gao XM, Fan GW
Drug Design, Development and Therapy 2015, 9:3051-3066
Published Date: 15 June 2015
Efficiency and safety of subconjunctival injection of anti-VEGF agent – bevacizumab – in treating dry eye
Jiang X, Lv H, Qiu W, Liu Z, Li X, Wang W
Drug Design, Development and Therapy 2015, 9:3043-3050
Published Date: 12 June 2015
Effect of database profile variation on drug safety assessment: an analysis of spontaneous adverse event reports of Japanese cases
Nomura K, Takahashi K, Hinomura Y, Kawaguchi G, Matsushita Y, Marui H, Anzai T, Hashiguchi M, Mochizuki M
Drug Design, Development and Therapy 2015, 9:3031-3041
Published Date: 12 June 2015
Oleanolic acid induces mitochondrial-dependent apoptosis and G0/G1 phase arrest in gallbladder cancer cells
Li HF, Wang XA, Xiang SS, Hu YP, Jiang L, Shu YJ, Li ML, Wu XS, Zhang F, Ye YY, Weng H, Bao RF, Cao Y, Lu W, Dong Q, Liu YB
Drug Design, Development and Therapy 2015, 9:3017-3030
Published Date: 12 June 2015
Osteopontin promotes dendritic cell maturation and function in response to HBV antigens
Cui GY, Chen JN, He JQ, Lu C, Wei YF, Wang L, Xu XJ, Li LJ, Uede T, Diao HY
Drug Design, Development and Therapy 2015, 9:3003-3016
Published Date: 12 June 2015
Involvement of NF-κB and HSP70 signaling pathways in the apoptosis of MDA-MB-231 cells induced by a prenylated xanthone compound, α-mangostin, from Cratoxylum arborescens [Corrigendum]
Ibrahim MY, Hashim NM, Mohan S, Abdulla MA, Abdelwahab SI, Kamalidehghan B, Ghaderian M, Dehghan F, Ali LZ, Karimian H, Yahayu M, Ee GCL, Farjam AS, Ali HM
Drug Design, Development and Therapy 2015, 9:3001-3002
Published Date: 12 June 2015
Assessment of hydroxychloroquine maculopathy after cessation of treatment: an optical coherence tomography and multifocal electroretinography study
Moschos MM, Nitoda E, Chatziralli IP, Gatzioufas Z, Koutsandrea C, Kitsos G
Drug Design, Development and Therapy 2015, 9:2993-2999
Published Date: 11 June 2015
Protective effect of galangin in Concanavalin A- induced hepatitis in mice
Luo Q, Zhu L, Ding J, Zhuang X, Xu L, Chen F
Drug Design, Development and Therapy 2015, 9:2983-2992
Published Date: 10 June 2015
Oxidant/antioxidant status, paraoxonase activity, and lipid profile in plasma of ovariectomized rats under the influence of estrogen, estrogen combined with progesterone, and genistein
Agacayak E, Basaranoglu S, Tunc SY, Icen MS, Findik FM, Kaplan I, Evliyaoglu O, Gul T
Drug Design, Development and Therapy 2015, 9:2975-2982
Published Date: 10 June 2015
Immunostimulatory effects of the standardized extract of Tinospora crispa on innate immune responses in Wistar Kyoto rats
Ahmad W, Jantan I, Kumolosasi E, Abbas Bukhari SN
Drug Design, Development and Therapy 2015, 9:2961-2973
Published Date: 10 June 2015
A novel bispecific immunotoxin delivered by human bone marrow-derived mesenchymal stem cells to target blood vessels and vasculogenic mimicry of malignant gliomas
Zhang Y, Sun X, Huang M, Ke Y, Wang J, Liu X
Drug Design, Development and Therapy 2015, 9:2947-2959
Published Date: 11 June 2015
Inflammation, cytokines, the IL-17/IL-6/STAT3/NF-κB axis, and tumorigenesis
Chen XW, Zhou SF
Drug Design, Development and Therapy 2015, 9:2941-2946
Published Date: 8 June 2015
Cissus quadrangularis inhibits IL-1β induced inflammatory responses on chondrocytes and alleviates bone deterioration in osteotomized rats via p38 MAPK signaling
Kanwar JR, Samarasinghe RM, Kumar K, Arya R, Sharma S, Zhou SF, Sasidharan S, Kanwar RK
Drug Design, Development and Therapy 2015, 9:2927-2940
Published Date: 5 June 2015
Profile of ceftolozane/tazobactam and its potential in the treatment of complicated intra-abdominal infections
Skalweit MJ
Drug Design, Development and Therapy 2015, 9:2919-2925
Published Date: 4 June 2015
Dose proportionality and pharmacokinetics of carvedilol sustained-release formulation: a single dose-ascending 10-sequence incomplete block study
Kim YH, Choi HY, Noh YH, Lee SH, Lim HS, Kim C, Bae KS
Drug Design, Development and Therapy 2015, 9:2911-2918
Published Date: 8 June 2015
Small-molecule BH3 mimetic and pan-Bcl-2 inhibitor AT-101 enhances the antitumor efficacy of cisplatin through inhibition of APE1 repair and redox activity in non-small-cell lung cancer
Ren T, Shan J, Li M, Qing Y, Qian C, Wang G, Li Q, Lu G, Li C, Peng Y, Luo H, Zhang S, Yang Y, Cheng Y, Wang D, Zhou SF
Drug Design, Development and Therapy 2015, 9:2887-2910
Published Date: 8 June 2015
Spotlight on pembrolizumab in the treatment of advanced melanoma
Rajakulendran T, Adam DN
Drug Design, Development and Therapy 2015, 9:2883-2886
Published Date: 4 June 2015
Protective effect of Huang Gan formula in 5/6 nephrectomized rats by depressing the Wnt/β-catenin signaling pathway
Mo LQ, Xiao XY, Song SL, Miao H, Liu ST, Guo D, Li X, Bu C, Hou LB, Yang XX
Drug Design, Development and Therapy 2015, 9:2867-2881
Published Date: 3 June 2015
Clinicopathological significance and potential drug target of RUNX3 in non-small cell lung cancer: a meta-analysis
Xu L, Lan H, Su Y, Li J, Wan J
Drug Design, Development and Therapy 2015, 9:2855-2865
Published Date: 3 June 2015
Efficacy of fimasartan/hydrochlorothiazide combination in hypertensive patients inadequately controlled by fimasartan monotherapy
Rhee MY, Baek SH, Kim W, Park CG, Park SW, Oh BH, Kim SH, Kim JJ, Shin JH, Yoo BS, Rim SJ, Ha JW, Doh JH, Ahn Y, Chae JK, Park JB, Kim SK, Kim CH
Drug Design, Development and Therapy 2015, 9:2847-2854
Published Date: 2 June 2015
Cost-effectiveness analysis of lamivudine, telbivudine, and entecavir in treatment of chronic hepatitis B with adefovir dipivoxil resistance
Wang G, Liu Y, Qiu P, Zhou SF, Xu L, Wen P, Wen J, Xiao X
Drug Design, Development and Therapy 2015, 9:2839-2846
Published Date: 2 June 2015
Applications of calixarenes in cancer chemotherapy: facts and perspectives
Yousaf A, Abd Hamid S, Bunnori NM, Ishola AA
Drug Design, Development and Therapy 2015, 9:2831-2838
Published Date: 2 June 2015
Neuroprotective and antioxidant effects of ghrelin in an experimental glaucoma model
Can N, Catak O, Turgut B, Demir T, Ilhan N, Kuloglu T, Ozercan IH
Drug Design, Development and Therapy 2015, 9:2819-2829
Published Date: 2 June 2015
Bioequivalence evaluation of two amlodipine salts, besylate and orotate, each in a fixed-dose combination with olmesartan in healthy subjects
Lee SY, Kim JR, Jung JA, Huh W, Bahng MY, Ko JW
Drug Design, Development and Therapy 2015, 9:2811-2817
Published Date: 2 June 2015
Itraconazole solid dispersion prepared by a supercritical fluid technique: preparation, in vitro characterization, and bioavailability in beagle dogs
Yin X, Daintree LS, Ding S, Ledger DM, Wang B, Zhao W, Qi J, Wu W
Drug Design, Development and Therapy 2015, 9:2801-2810
Published Date: 28 May 2015
Isolation and evaluation of anticancer efficacy of stigmasterol in a mouse model of DMBA-induced skin carcinoma
Ali H, Dixit S, Ali D, Alqahtani SM, Alkahtani S, Alarifi S
Drug Design, Development and Therapy 2015, 9:2793-2800
Published Date: 28 May 2015
Clinical evaluation of the efficacy and safety of a medical device in various forms containing Triticum vulgare for the treatment of venous leg ulcers – a randomized pilot study
Romanelli M, Macchia M, Panduri S, Paggi B, Saponati G, Dini V
Drug Design, Development and Therapy 2015, 9:2787-2792
Published Date: 27 May 2015
Role of sodium tungstate as a potential antiplatelet agent
Fernández-Ruiz R, Pino M, Hurtado B, García de Frutos P, Caballo C, Escolar G, Gomis R, Diaz-Ricart M
Drug Design, Development and Therapy 2015, 9:2777-2786
Published Date: 26 May 2015
Population pharmacokinetics of methylphenidate hydrochloride extended-release multiple-layer beads in pediatric subjects with attention deficit hyperactivity disorder
Teuscher NS, Adjei A, Findling RL, Greenhill LL, Kupper RJ, Wigal S
Drug Design, Development and Therapy 2015, 9:2767-2775
Published Date: 26 May 2015
Combination therapy of fenofibrate and ursodeoxycholic acid in patients with primary biliary cirrhosis who respond incompletely to UDCA monotherapy: a meta-analysis
Zhang Y, Li S, He L, Wang F, Chen K, Li J, Liu T, Zheng Y, Wang J, Lu W, Zhou Y, Yin Q, Xia Y, Zhou Y, Lu J, Guo C
Drug Design, Development and Therapy 2015, 9:2757-2766
Published Date: 25 May 2015
Soluplus®/TPGS-based solid dispersions prepared by hot-melt extrusion equipped with twin-screw systems for enhancing oral bioavailability of valsartan
Lee JY, Kang WS, Piao J, Yoon IS, Kim DD, Cho HJ
Drug Design, Development and Therapy 2015, 9:2745-2756
Published Date: 22 May 2015
Antitumor effects of traditional Chinese medicine targeting the cellular apoptotic pathway
Xu HL, Zhao X, Liu XH, Xu PX, Zhang KM, Lin XK
Drug Design, Development and Therapy 2015, 9:2735-2744
Published Date: 21 May 2015
Effects of strontium ranelate on bone formation in the mid-palatal suture after rapid maxillary expansion
Zhao SY, Wang XX, Li N, Chen Y, Su YR, Zhang J
Drug Design, Development and Therapy 2015, 9:2725-2734
Published Date: 21 May 2015
Comments on a systematic review and meta-analysis of steroids for epidural injections in spinal stenosis
Manchikanti L, Hirsch JA
Drug Design, Development and Therapy 2015, 9:2721-2724
Published Date: 20 May 2015
Synthesis and characterization of tumor-targeted copolymer nanocarrier modified by transferrin
Liu R, Wang Y, Li X, Bao W, Xia G, Chen W, Cheng J, Xu Y, Guo L, Chen B
Drug Design, Development and Therapy 2015, 9:2705-2719
Published Date: 22 May 2015
Anti-Warburg effect of rosmarinic acid via miR-155 in gastric cancer cells
Han S, Yang SH, Cai Z, Pan DY, Li Z, Huang ZH, Zhang PS, Zhu HJ, Lei LJ, Wang WW
Drug Design, Development and Therapy 2015, 9:2695-2703
Published Date: 19 May 2015
Impact of JAK2(V617F) mutation status on treatment response to anagrelide in essential thrombocythemia: an observational, hypothesis-generating study
Cascavilla N, De Stefano V, Pane F, Pancrazzi A, Iurlo A, Gobbi M, Palandri F, Specchia G, Liberati AM, D’Adda M, Gaidano G, Fjerza R, Achenbach H, Smith J, Wilde P, Vannucchi AM
Drug Design, Development and Therapy 2015, 9:2687-2694
Published Date: 18 May 2015
The usefulness of ozone treatment in spinal pain
Bocci V, Borrelli E, Zanardi I, Travagli V
Drug Design, Development and Therapy 2015, 9:2677-2685
Published Date: 15 May 2015
DNA stabilization by the upregulation of estrogen signaling in BRCA gene mutation carriers
Suba Z
Drug Design, Development and Therapy 2015, 9:2663-2675
Published Date: 15 May 2015
A thorough QT study to assess the effects of tbo-filgrastim on cardiac repolarization in healthy subjects
Adar L, Avisar N, Lammerich A, Kleiman RB, Spiegelstein O
Drug Design, Development and Therapy 2015, 9:2653-2662
Published Date: 15 May 2015
Construction of interference vector targeting Ep-CAM gene and its effects on colorectal cancer cell proliferation
Qi Y, Zhou F, Zhang L, Liu L, Xu H, Guo H
Drug Design, Development and Therapy 2015, 9:2647-2652
Published Date: 14 May 2015
A study on the hemocompatibility of dendronized chitosan derivatives in red blood cells
Zhou YF, Li JM, Lu F, Deng JJ, Zhang JH, Fang PJ, Peng XS, Zhou SF
Drug Design, Development and Therapy 2015, 9:2635-2645
Published Date: 14 May 2015
Prevalence of the CYP2D6*10 (C100T), *4 (G1846A), and *14 (G1758A) alleles among Iranians of different ethnicities
Bagheri A, Kamalidehghan B, Haghshenas M, Azadfar P, Akbari L, Sangtarash MH, Vejdandoust F, Ahmadipour F, Meng GY, Houshmand M
Drug Design, Development and Therapy 2015, 9:2627-2634
Published Date: 13 May 2015
Fixed-combination treatments for intraocular hypertension in Chinese patients – focus on bimatoprost-timolol
Fang Y, Ling Z, Sun X
Drug Design, Development and Therapy 2015, 9:2617-2625
Published Date: 13 May 2015
A pharmacokinetic comparison of two voriconazole formulations and the effect of CYP2C19 polymorphism on their pharmacokinetic profiles
Chung H, Lee H, Han H, An H, Lim KS, Lee YJ, Cho JY, Yoon SH, Jang IJ, Yu KS
Drug Design, Development and Therapy 2015, 9:2609-2616
Published Date: 13 May 2015
A quest to increase safety of anesthetics by advancements in anesthesia monitoring: scientometric analysis
Vlassakov KV, Kissin I
Drug Design, Development and Therapy 2015, 9:2599-2608
Published Date: 11 May 2015
Ferrous sulfate, but not iron polymaltose complex, aggravates local and systemic inflammation and oxidative stress in dextran sodium sulfate-induced colitis in rats
Toblli JE, Cao G, Angerosa M
Drug Design, Development and Therapy 2015, 9:2585-2597
Published Date: 7 May 2015
Update on the clinical utility of once-daily tacrolimus in the management of transplantation
Revollo J
Drug Design, Development and Therapy 2015, 9:2581-2584
Published Date: 7 May 2015
Skin regeneration in deep second-degree scald injuries either by infusion pumping or topical application of recombinant human erythropoietin gel
Giri P, Ebert S, Braumann UD, Kremer M, Giri S, Machens HG, Bader A
Drug Design, Development and Therapy 2015, 9:2565-2579
Published Date: 11 May 2015
Aging-related rotenone-induced neurochemical and behavioral deficits: role of SIRT2 and redox imbalance, and neuroprotection by AK-7
Wang X, Guan Q, Wang M, Yang L, Bai J, Yan Z, Zhang Y, Liu Z
Drug Design, Development and Therapy 2015, 9:2553-2563
Published Date: 7 May 2015
The mazEF toxin–antitoxin system as an attractive target in clinical isolates of Enterococcus faecium and Enterococcus faecalis
Soheili S, Ghafourian S, Sekawi Z, Neela VK, Sadeghifard N, Taherikalani M, Khosravi A, Ramli R, Hamat RA
Drug Design, Development and Therapy 2015, 9:2553-2561
Published Date: 8 May 2015
Sonodynamic effect of hematoporphyrin monomethyl ether on ligature-induced periodontitis in rats
Zhuang DS, Han JL, Bi LJ, Wang YP, Hao YR, Zhou Q, Cao WW
Drug Design, Development and Therapy 2015, 9:2545-2551
Published Date: 6 May 2015
A prospective treatment for sepsis
Shahidi Bonjar MR, Shahidi Bonjar L
Drug Design, Development and Therapy 2015, 9:2537-2543
Published Date: 6 May 2015
Efficacy and safety of different doses of a slow-release corticosteroid implant for macular edema: meta-analysis of randomized controlled trials
Liu QY, He MM, Shi H, Wang QY, Du YR, Liu JL, Ren CD, Xu D, Yu J
Drug Design, Development and Therapy 2015, 9:2527-2535
Published Date: 5 May 2015
Impact of streptozotocin on altering normal glucose homeostasis during insulin testing in diabetic rats compared to normoglycemic rats
Qinna NA, Badwan AA
Drug Design, Development and Therapy 2015, 9:2515-2525
Published Date: 5 May 2015
Preparation and characterization of genipin-cross-linked silk fibroin/chitosan sustained-release microspheres
Zeng SG, Ye MW, Qiu JQ, Fang W, Rong MD, Guo ZH, Gao WF
Drug Design, Development and Therapy 2015, 9:2501-2514
Published Date: 4 May 2015
Body protective compound-157 enhances alkali-burn wound healing in vivo and promotes proliferation, migration, and angiogenesis in vitro
Huang T, Zhang K, Sun L, Xue X, Zhang C, Shu Z, Mu N, Gu J, Zhang W, Wang Y, Zhang Y, Zhang W
Drug Design, Development and Therapy 2015, 9:2485-2499
Published Date: 30 April 2015
Enhanced anti-inflammatory potential of cinnamate-zinc layered hydroxide in lipopolysaccharide-stimulated RAW 264.7 macrophages
Adewoyin M, Mohsin SMN, Arulselvan P, Hussein MZ, Fakurazi S
Drug Design, Development and Therapy 2015, 9:2475-2484
Published Date: 30 April 2015
The mechanism of CCN1-enhanced retinal neovascularization in oxygen-induced retinopathy through PI3K/Akt–VEGF signaling pathway
Di Y, Zhang Y, Yang H, Wang A, Chen X
Drug Design, Development and Therapy 2015, 9:2463-2473
Published Date: 30 April 2015
Structural dynamics and inhibitor searching for Wnt-4 protein using comparative computational studies
Hammad MA, Azam SS
Drug Design, Development and Therapy 2015, 9:2449-2461
Published Date: 29 April 2015
Preparation and clinical evaluation of nano-transferosomes for treatment of erectile dysfunction
Ali MFM, Salem HF, Abdelmohsen HF, Attia SK
Drug Design, Development and Therapy 2015, 9:2431-2447
Published Date: 29 April 2015
Pharmacokinetics of mitragynine in man
Trakulsrichai S, Sathirakul K, Auparakkitanon S, Krongvorakul J, Sueajai J, Noumjad N, Sukasem C, Wananukul W
Drug Design, Development and Therapy 2015, 9:2421-2429
Published Date: 29 April 2015
Ultrasound contrast agent loaded with nitric oxide as a theranostic microdevice
Grishenkov D, Gonon A, Weitzberg E, Lundberg JO, Harmark J, Cerroni B, Paradossi G, Janerot-Sjoberg B
Drug Design, Development and Therapy 2015, 9:2409-2419
Published Date: 29 April 2015
Wnt blockers inhibit the proliferation of lung cancer stem cells
Zhang X, Lou Y, Zheng X, Wang H, Sun J, Dong Q, Han B
Drug Design, Development and Therapy 2015, 9:2399-2407
Published Date: 28 April 2015
Development of acquired factor V inhibitor after treatment with ceftazidime: a case report and review of the literature
Cui QY, Shen HS, Wu TQ, Chen HF, Yu ZQ, Wang ZY
Drug Design, Development and Therapy 2015, 9:2395-2398
Published Date: 24 April 2015
Structure–activity exploration of a small-molecule Lipid II inhibitor
Fletcher S, Yu W, Huang J, Kwasny SM, Chauhan J, Opperman TJ, MacKerell Jr AD, de Leeuw EPH
Drug Design, Development and Therapy 2015, 9:2383-2394
Published Date: 24 April 2015
Apolipoprotein M regulates the orphan nuclear receptor LRH-1 gene expression through binding to its promoter region in HepG2 cells
Pan Y, Zhou HG, Zhou H, Hu M, Tang LJ
Drug Design, Development and Therapy 2015, 9:2375-2382
Published Date: 24 April 2015
Changing the face of hepatitis C management – the design and development of sofosbuvir
Noell BC, Besur SV, deLemos AS
Drug Design, Development and Therapy 2015, 9:2367-2374
Published Date: 24 April 2015
Comparative fasting bioavailability of two clopidogrel formulations in healthy Mediterranean volunteers: an in vitro–in vivo correlation
Zaid AN, Al Ramahi R, Bustami R, Mousa A, Khasawneh S
Drug Design, Development and Therapy 2015, 9:2359-2365
Published Date: 24 April 2015
Critical appraisal of bevacizumab in the treatment of ovarian cancer
Yoshida H, Yabuno A, Fujiwara K
Drug Design, Development and Therapy 2015, 9:2351-2358
Published Date: 28 April 2015
Efficacy and safety of ramosetron versus ondansetron for postoperative nausea and vomiting after general anesthesia: a meta-analysis of randomized clinical trials
Gao CJ, Li B, Xu LF, Lv FB, Cao GM, Wang HX, Wang F, Wu GH
Drug Design, Development and Therapy 2015, 9:2343-2350
Published Date: 23 April 2015
Modifying tetramethyl–nitrophenyl–imidazoline with amino acids: design, synthesis, and 3D-QSAR for improving inflammatory pain therapy
Jiang X, Wang Y, Zhu H, Wang Y, Zhao M, Zhao S, Wu J, Li S, Peng S
Drug Design, Development and Therapy 2015, 9:2329-2342
Published Date: 22 April 2015
A novel misoprostol delivery system for induction of labor: clinical utility and patient considerations
Stephenson ML, Wing DA
Drug Design, Development and Therapy 2015, 9:2321-2327
Published Date: 22 April 2015
Profile of conbercept in the treatment of neovascular age-related macular degeneration
Lu XM, Sun XD
Drug Design, Development and Therapy 2015, 9:2311-2320
Published Date: 22 April 2015
Preparation, characterization, and in vivo study of rhein-loaded poly(lactic-co-glycolic acid) nanoparticles for oral delivery
Yuan Z, Gu XH
Drug Design, Development and Therapy 2015, 9:2301-2309
Published Date: 21 April 2015
Evaluation of the protective effects of curcuminoid (curcumin and bisdemethoxycurcumin)-loaded liposomes against bone turnover in a cell-based model of osteoarthritis
Yeh CC, Su YH, Lin YJ, Chen PJ, Shi CS, Chen CN, Chang HI
Drug Design, Development and Therapy 2015, 9:2285-2300
Published Date: 20 April 2015
Brentuximab vedotin for treatment of relapsed or refractory malignant lymphoma: results of a systematic review and meta-analysis of prospective studies
Chen R, Wang F, Zhang H, Chen B
Drug Design, Development and Therapy 2015, 9:2277-2283
Published Date: 20 April 2015
RETRACTED ARTICLE: A novel glycyrrhetinic acid-modified oxaliplatin liposome for liver-targeting and in vitro/vivo evaluation
Chen J, Jiang H, Wu Y, Li Y, Gao Y
Drug Design, Development and Therapy 2015, 9:2265-2275
Published Date: 20 April 2015
HDACiDB: a database for histone deacetylase inhibitors
Murugan K, Sangeetha S, Ranjitha S, Vimala A, Al-Sohaibani S, Rameshkumar G
Drug Design, Development and Therapy 2015, 9:2257-2264
Published Date: 20 April 2015
Comparison of reendothelialization and neointimal formation with stents coated with antibodies against endoglin and CD34 in a porcine model
Cui S, Song XT, Ding C, Meng LJ, Lv SZ, Li K
Drug Design, Development and Therapy 2015, 9:2249-2256
Published Date: 17 April 2015
Promoting endothelial function by S-nitrosoglutathione through the HIF-1α/VEGF pathway stimulates neurorepair and functional recovery following experimental stroke in rats
Khan M, Dhammu TS, Matsuda F, Baarine M, Dhindsa TS, Singh I, Singh AK
Drug Design, Development and Therapy 2015, 9:2233-2247
Published Date: 17 April 2015
Emerging therapies for patients with symptoms of opioid-induced bowel dysfunction
Leppert W
Drug Design, Development and Therapy 2015, 9:2215-2231
Published Date: 16 April 2015
Anticancer activity of streptochlorin, a novel antineoplastic agent, in cholangiocarcinoma
Kwak TW, Shin HJ, Jeong YI, Han ME, Oh SO, Kim HJ, Kim DH, Kang DH
Drug Design, Development and Therapy 2015, 9:2201-2214
Published Date: 16 April 2015
Nanoparticle albumin-bound paclitaxel (nab-paclitaxel) as second-line chemotherapy in HER2-negative, taxane-pretreated metastatic breast cancer patients: prospective evaluation of activity, safety, and quality of life
Palumbo R, Sottotetti F, Trifirò G, Piazza E, Ferzi A, Gambaro A, Spinapolice EG, Pozzi E, Tagliaferri B, Teragni C, Bernardo A
Drug Design, Development and Therapy 2015, 9:2189-2199
Published Date: 15 April 2015
Transgenic animal models for study of the pathogenesis of Huntington’s disease and therapy
Chang RB, Liu XD, Li SH, Li XJ
Drug Design, Development and Therapy 2015, 9:2179-2188
Published Date: 15 April 2015
Clinicopathological significance and potential drug targeting of CDH1 in lung cancer: a meta-analysis and literature review
Yu Q, Guo Q, Chen L, Liu S
Drug Design, Development and Therapy 2015, 9:2171-2178
Published Date: 15 April 2015
Evaluation of combined famotidine with quercetin for the treatment of peptic ulcer: in vivo animal study
Abourehab MA, Khaled KA, Sarhan HA, Ahmed OA
Drug Design, Development and Therapy 2015, 9:2159-2169
Published Date: 13 April 2015
The clinicopathological significance of CDH1 in gastric cancer: a meta-analysis and systematic review
Zeng W, Zhu J, Shan L, Han Z, Aerxiding P, Quhai A, Zeng F, Wang Z, Li H
Drug Design, Development and Therapy 2015, 9:2149-2157
Published Date: 13 April 2015
Paclitaxel attenuates renal interstitial fibroblast activation and interstitial fibrosis by inhibiting STAT3 signaling
Zhang L, Xu X, Yang R, Chen J, Wang S, Yang JQ, Xiang X, He Z, Zhao Y, Dong Z, Zhang D
Drug Design, Development and Therapy 2015, 9:2139-2148
Published Date: 15 April 2015
Update on the management of severe hypertriglyceridemia – focus on free fatty acid forms of omega-3
Pirillo A, Catapano AL
Drug Design, Development and Therapy 2015, 9:2129-2137
Published Date: 10 April 2015
Roles of Ca2+/calmodulin-dependent protein kinase II in subcellular expression of striatal N-Methyl-D-aspartate receptors in L-3, 4-dihydroxyphenylalanine-induced dyskinetic rats
Gan J, Qi C, Liu Z
Drug Design, Development and Therapy 2015, 9:2119-2128
Published Date: 13 April 2015
D-cycloserine augmentation in behavioral therapy for obsessive-compulsive disorder: a meta-analysis
Xia J, Du Y, Han J, Liu G, Wang X
Drug Design, Development and Therapy 2015, 9:2101-2117
Published Date: 21 April 2015
Drug delivery strategies to enhance the permeability of the blood–brain barrier for treatment of glioma
Zhang F, Xu CL, Liu CM
Drug Design, Development and Therapy 2015, 9:2089-2100
Published Date: 9 April 2015
Management of severe sepsis: advances, challenges, and current status
Martin-Loeches I, Levy MM, Artigas A
Drug Design, Development and Therapy 2015, 9:2079-2088
Published Date: 9 April 2015
Impact of potential inappropriate NSAIDs use in chronic pain
Ussai S, Miceli L, Pisa FE, Bednarova R, Giordano A, Della Rocca G, Petelin R
Drug Design, Development and Therapy 2015, 9:2073-2077
Published Date: 9 April 2015
Efficacy and safety of cross-linked hyaluronic acid single injection on osteoarthritis of the knee: a post-marketing phase IV study
Bashaireh K, Naser Z, Hawadya KA, Sorour S, Al-Khateeb RN
Drug Design, Development and Therapy 2015, 9:2063-2072
Published Date: 8 April 2015
The biological effects of tocotrienol on bone: a review on evidence from rodent models
Chin KY, Ima-Nirwana S
Drug Design, Development and Therapy 2015, 9:2049-2061
Published Date: 8 April 2015
Quinoline-based clioquinol and nitroxoline exhibit anticancer activity inducing FoxM1 inhibition in cholangiocarcinoma cells
Chan-on W, Huyen NTB, Songtawee N, Suwanjang W, Prachayasittikul S, Prachayasittikul V
Drug Design, Development and Therapy 2015, 9:2033-2047
Published Date: 8 April 2015
Targeting the hypoxia pathway to treat pancreatic cancer
Erickson LA, Highsmith Jr WE, Fei P, Zhang J
Drug Design, Development and Therapy 2015, 9:2029-2031
Published Date: 8 April 2015
Schisandrin B inhibits cell growth and induces cellular apoptosis and autophagy in mouse hepatocytes and macrophages: implications for its hepatotoxicity
Zhang Y, Zhou ZW, Jin H, Hu C, He ZX, Yu ZL, Ko KM, Yang T, Zhang X, Pan SY, Zhou SF
Drug Design, Development and Therapy 2015, 9:2001-2027
Published Date: 9 April 2015
Aclidinium bromide/formoterol fixed-dose combination therapy for COPD: the evidence to date
Moitra S, Bhome AB, Brashier BB
Drug Design, Development and Therapy 2015, 9:1989-1999
Published Date: 7 April 2015
Canakinumab as rescue therapy in familial Mediterranean fever refractory to conventional treatment
Alpa M, Roccatello D
Drug Design, Development and Therapy 2015, 9:1983-1987
Published Date: 17 April 2015
The effects of amlodipine and platelet rich plasma on bone healing in rats
Atalay Y, Bozkurt MF, Gonul Y, Cakmak O, Agacayak KS, Köse I, Hazman O, Keles H, Turamanlar O, Eroglu M
Drug Design, Development and Therapy 2015, 9:1973-1981
Published Date: 7 April 2015
Effect of aliskiren on cardiovascular outcomes in patients with prehypertension: a meta-analysis of randomized controlled trials
Zhang JT, Chen KP, Guan T, Zhang S
Drug Design, Development and Therapy 2015, 9:1963-1971
Published Date: 2 April 2015
Gelatin nanoparticle-mediated intranasal delivery of substance P protects against 6-hydroxydopamine-induced apoptosis: an in vitro and in vivo study
Lu CT, Jin RR, Jiang YN, Lin Q, Yu WZ, Mao KL, Tian FR, Zhao YP, zhao YZ
Drug Design, Development and Therapy 2015, 9:1955-1962
Published Date: 7 April 2015
Impact of enzyme replacement therapy and hematopoietic stem cell transplantation in patients with Morquio A syndrome
Tomatsu S, Sawamoto K, Alméciga-Díaz CJ, Shimada T, Bober MB, Chinen Y, Yabe H, Montaño AM, Giugliani R, Kubaski F, Yasuda E, Rodríguez-López A, Espejo-Mojica AJ, Sánchez OF, Mason RW, Barrera LA, Mackenzie WG, Orii T
Drug Design, Development and Therapy 2015, 9:1937-1953
Published Date: 1 April 2015
Comparative efficacy, acceptability, and tolerability of lisdexamfetamine in child and adolescent ADHD: a meta-analysis of randomized, controlled trials
Maneeton B, Maneeton N, Likhitsathian S, Suttajit S, Narkpongphun A, Srisurapanont M, Woottiluk P
Drug Design, Development and Therapy 2015, 9:1927-1936
Published Date: 1 April 2015
Clinical and pharmacological properties of incobotulinumtoxinA and its use in neurological disorders
Jost WH, Benecke R, Hauschke D, Jankovic J, Kaňovský P, Roggenkämper P, Simpson DM, Comella CL
Drug Design, Development and Therapy 2015, 9:1913-1926
Published Date: 1 April 2015
Modeling, molecular dynamics, and docking assessment of transcription factor rho: a potential drug target in Brucella melitensis 16M
Pradeepkiran JA, Kumar KK, Kumar YN, Bhaskar M
Drug Design, Development and Therapy 2015, 9:1897-1912
Published Date: 31 March 2015
Visual detection of glial cell line-derived neurotrophic factor based on a molecular translator and isothermal strand-displacement polymerization reaction
Zhang LY, Xing T, Du LX, Li QM, Liu WD, Wang JY, Cai J
Drug Design, Development and Therapy 2015, 9:1889-1896
Published Date: 31 March 2015
A perspective on the benefit-risk assessment for new and emerging pharmaceuticals in Japan
Tanimoto T
Drug Design, Development and Therapy 2015, 9:1877-1888
Published Date: 31 March 2015
Liraglutide and obesity: a review of the data so far
Ladenheim EE
Drug Design, Development and Therapy 2015, 9:1867-1875
Published Date: 30 March 2015
Profile of atacicept and its potential in the treatment of systemic lupus erythematosus [Corrigendum]
Cogollo E, Silva MA, Isenberg D
Drug Design, Development and Therapy 2015, 9:1865-1866
Published Date: 31 March 2015
Comparative efficacy of pitavastatin and simvastatin in patients with hypercholesterolemia: a meta-analysis of randomized controlled clinical trials
Ma N, Cui LQ
Drug Design, Development and Therapy 2015, 9:1859-1864
Published Date: 31 March 2015
Design and evaluation of effervescent floating tablets based on hydroxyethyl cellulose and sodium alginate using pentoxifylline as a model drug
Abdel Rahim S, Carter PA, Elkordy AA
Drug Design, Development and Therapy 2015, 9:1843-1857
Published Date: 31 March 2015
Pharmacoinformatics approach for investigation of alternative potential hepatitis C virus nonstructural protein 5B inhibitors
Mirza MU, Ghori NUH, Ikram N, Adil AR, Manzoor S
Drug Design, Development and Therapy 2015, 9:1825-1841
Published Date: 27 March 2015
Paracellular permeation-enhancing effect of AT1002 C-terminal amidation in nasal delivery
Song KH, Kim SB, Shim CK, Chung SJ, Kim DD, Rhee SK, Choi GJ, Kim CH, Kim K
Drug Design, Development and Therapy 2015, 9:1815-1823
Published Date: 27 March 2015
Novel nanoliposomal delivery system for polydatin: preparation, characterization, and in vivo evaluation
Wang X, Guan Q, Chen W, Hu X, Li L
Drug Design, Development and Therapy 2015, 9:1805-1813
Published Date: 30 March 2015
Recent progress in fungus-derived bioactive agents for targeting of signaling machinery in cancer cells
Lin X, Farooqi AA, Ismail M
Drug Design, Development and Therapy 2015, 9:1797-1804
Published Date: 26 March 2015
Clinical significance of DAPK promoter hypermethylation in lung cancer: a meta-analysis
Li Y, Zhu M, Zhang X, Cheng D, Ma X
Drug Design, Development and Therapy 2015, 9:1785-1796
Published Date: 24 March 2015
Lost expression of ADAMTS5 protein associates with progression and poor prognosis of hepatocellular carcinoma
Li C, Xiong Y, Yang X, Wang L, Zhang S, Dai N, Li M, Ren T, Yang Y, Zhou SF, Gan L, Wang D
Drug Design, Development and Therapy 2015, 9:1773-1783
Published Date: 24 March 2015
Turoctocog alfa: an evidence-based review of its potential in the treatment of hemophilia A
Takedani H, Hirose J
Drug Design, Development and Therapy 2015, 9:1767-1772
Published Date: 24 March 2015
Effect of varying doses of tamoxifen on ovarian histopathology, serum VEGF, and endothelin 1 levels in ovarian hyperstimulation syndrome: an experimental study
Pala S, Atilgan R, Ozkan ZS, Kavak SB, Ilhan N, Akpolat N, Sapmaz E
Drug Design, Development and Therapy 2015, 9:1761-1766
Published Date: 24 March 2015
Design and prediction of new anticoagulants as a selective Factor IXa inhibitor via three-dimensional quantitative structure-property relationships of amidinobenzothiophene derivatives
Gao JS, Tong XP, Chang YQ, He YX, Mei YD, Tan PH, Guo JL, Liao GC, Xiao GK, Chen WM, Zhou SF, Sun PH
Drug Design, Development and Therapy 2015, 9:1743-1759
Published Date: 23 March 2015
Single and multiple dose pharmacokinetics and tolerability of HX-1171, a novel antioxidant, in healthy volunteers
Kim YH, Choi HY, Lee SH, Lim HS, Miki T, Kang JK, Han KG, Bae KS
Drug Design, Development and Therapy 2015, 9:1735-1742
Published Date: 23 March 2015
Brentuximab vedotin for relapsed or refractory Hodgkin’s lymphoma
Chen R, Chen B
Drug Design, Development and Therapy 2015, 9:1729-1733
Published Date: 23 March 2015
Glu-Trp-ONa or its acylated analogue (R-Glu-Trp-ONa) administration enhances the wound healing in the model of chronic skin wounds in rabbits
Shevtsov MA, Smagina LV, Kudriavtceva TA, Petlenko SV, Voronkina IV
Drug Design, Development and Therapy 2015, 9:1717-1727
Published Date: 20 March 2015
Solifenacin/tamsulosin fixed-dose combination therapy to treat lower urinary tract symptoms in patients with benign prostatic hyperplasia
Dimitropoulos K, Gravas S
Drug Design, Development and Therapy 2015, 9:1707-1716
Published Date: 19 March 2015
Complete genome-wide screening and subtractive genomic approach revealed new virulence factors, potential drug targets against bio-war pathogen Brucella melitensis 16M
Pradeepkiran JA, Sainath SB, Kumar KK, Bhaskar M
Drug Design, Development and Therapy 2015, 9:1691-1706
Published Date: 19 March 2015
Human colon carcinogenesis is associated with increased interleukin-17-driven inflammatory responses
Xie Z, Qu Y, Leng Y, Sun W, Ma S, Wei J, Hu J, Zhang X
Drug Design, Development and Therapy 2015, 9:1679-1689
Published Date: 18 March 2015
Synthesis and biological evaluation of a novel class of curcumin analogs as anti-inflammatory agents for prevention and treatment of sepsis in mouse model
Zhao C, Zhang Y, Zou P, Wang J, He W, Shi D, Li H, Liang G, Yang S
Drug Design, Development and Therapy 2015, 9:1663-1678
Published Date: 18 March 2015
A phase I/II study of biweekly capecitabine and irinotecan plus bevacizumab as second-line chemotherapy in patients with metastatic colorectal cancer
Suenaga M, Mizunuma N, Matsusaka S, Shinozaki E, Ozaka M, Ogura M, Chin K, Yamaguchi T
Drug Design, Development and Therapy 2015, 9:1653-1662
Published Date: 16 March 2015
The investigational Aurora kinase A inhibitor alisertib (MLN8237) induces cell cycle G2/M arrest, apoptosis, and autophagy via p38 MAPK and Akt/mTOR signaling pathways in human breast cancer cells
Li JP, Yang YX, Liu QL, Pan ST, He ZX, Zhang X, Yang T, Chen XW, Wang D, Qiu JX, Zhou SF
Drug Design, Development and Therapy 2015, 9:1627-1652
Published Date: 16 March 2015
Plumbagin induces G2/M arrest, apoptosis, and autophagy via p38 MAPK- and PI3K/Akt/mTOR-mediated pathways in human tongue squamous cell carcinoma cells
Pan ST, Qin Y, Zhou ZW, He ZX, Zhang X, Yang T, Yang YX, Wang D, Qiu JX, Zhou SF
Drug Design, Development and Therapy 2015, 9:1601-1626
Published Date: 16 March 2015
The application of click chemistry in the synthesis of agents with anticancer activity
Ma N, Wang Y, Zhao BX, Ye WC, Jiang S
Drug Design, Development and Therapy 2015, 9:1585-1599
Published Date: 12 March 2015
Pro-apoptotic and pro-autophagic effects of the Aurora kinase A inhibitor alisertib (MLN8237) on human osteosarcoma U-2 OS and MG-63 cells through the activation of mitochondria-mediated pathway and inhibition of p38 MAPK/PI3K/Akt/mTOR signaling pathway
Niu NK, Wang ZL, Pan ST, Ding HQ, Au GHT, He ZX, Zhou ZW, Xiao G, Yang YX, Zhang X, Yang T, Chen XW, Qiu JX, Zhou SF
Drug Design, Development and Therapy 2015, 9:1555-1584
Published Date: 12 March 2015
Induction of apoptosis and autophagy via sirtuin1- and PI3K/Akt/mTOR-mediated pathways by plumbagin in human prostate cancer cells
Zhou ZW, Li XX, He ZX, Pan ST, Yang Y, Zhang X, Chow K, Yang T, Qiu JX, Zhou Q, Tan J, Wang D, Zhou SF
Drug Design, Development and Therapy 2015, 9:1511-1554
Published Date: 12 March 2015
Em08red, a dual functional antiproliferative emodin analogue, is a downregulator of ErbB2 expression and inducer of intracellular oxidative stress
Liang FP, Lien JC, Wu YH, Chen CS, Juang SH
Drug Design, Development and Therapy 2015, 9:1499-1510
Published Date: 12 March 2015
Effect of a topical copper indomethacin gel on inflammatory parameters in a rat model of osteoarthritis
Yassin NZ, El-Shenawy SM, Abdel-Rahman RF, Yakoot M, Hassan M, Helmy S
Drug Design, Development and Therapy 2015, 9:1491-1498
Published Date: 12 March 2015
Positive effects on hematological and biochemical imbalances in patients with metastatic breast cancer stage IV, of BP-C1, a new anticancer substance
Lindkær-Jensen S, Larsen S, Habib-Lindkær-Jensen N, Fagertun HE
Drug Design, Development and Therapy 2015, 9:1481-1490
Published Date: 13 March 2015
Neuroprotective therapies for glaucoma
Song W, Huang P, Zhang C
Drug Design, Development and Therapy 2015, 9:1469-1479
Published Date: 11 March 2015
Design, synthesis, and antifungal activities of novel triazole derivatives containing the benzyl group
Xu K, Huang L, Xu Z, Wang Y, Bai G, Wu Q, Wang X, Yu S, Jiang Y
Drug Design, Development and Therapy 2015, 9:1459-1467
Published Date: 11 March 2015
Cryo-ablation improves anti-tumor immunity through recovering tumor educated dendritic cells in tumor-draining lymph nodes
He XZ, Wang QF, Han S, Wang HQ, Ye YY, Zhu ZY, Zhang SZ
Drug Design, Development and Therapy 2015, 9:1449-1458
Published Date: 10 March 2015
Liriodenine, an aporphine alkaloid from Enicosanthellum pulchrum, inhibits proliferation of human ovarian cancer cells through induction of apoptosis via the mitochondrial signaling pathway and blocking cell cycle progression
Nordin N, Majid NA, Hashim NM, Rahman MA, Hassan Z, Ali HM
Drug Design, Development and Therapy 2015, 9:1437-1448
Published Date: 10 March 2015
Improved corneal bioavailability of ofloxacin: biodegradable microsphere-loaded ion-activated in situ gel delivery system
Sayed EG, Hussein AK, Khaled KA, Ahmed OAA
Drug Design, Development and Therapy 2015, 9:1427-1435
Published Date: 10 March 2015
Single dose pharmacokinetics of the novel transdermal donepezil patch in healthy volunteers
Kim YH, Choi HY, Lim HS, Lee SH, Jeon HS, Hong D, Kim SS, Choi YK, Bae KS
Drug Design, Development and Therapy 2015, 9:1419-1426
Published Date: 10 March 2015
In vivo antitumor and antimetastatic effects of flavokawain B in 4T1 breast cancer cell-challenged mice
Abu N, Mohamad NE, Yeap SK, Lim KL, Akhtar MN, Zulfadli AJ, Beh BK, Abdullah MP, Omar AR, Alitheen NB
Drug Design, Development and Therapy 2015, 9:1401-1417
Published Date: 6 March 2015
Steroids as an adjunct for reducing the incidence of proliferative vitreoretinopathy after rhegmatogenous retinal detachment surgery: a systematic review and meta-analysis
Shi H, Guo T, Liu PC, Wang QY, Du YR, Liu QY, He MM, Liu JL, Yu J
Drug Design, Development and Therapy 2015, 9:1393-1400
Published Date: 6 March 2015
Development and optimization of carvedilol orodispersible tablets: enhancement of pharmacokinetic parameters in rabbits
Aljimaee YH, El-Helw AM, Ahmed OA, El-Say KM
Drug Design, Development and Therapy 2015, 9:1379-1392
Published Date: 5 March 2015
Evaluation of cationic polyamidoamine dendrimers’ dermal toxicity in the rat skin model
Winnicka K, Wroblewska M, Sosnowska K, Car H, Kasacka I
Drug Design, Development and Therapy 2015, 9:1367-1377
Published Date: 5 March 2015
Development and in vitro characterization of drug delivery system of rifapentine for osteoarticular tuberculosis
Wu J, Zuo Y, Hu YJ, Wang J, Li JD, Qiao B, Jiang DM
Drug Design, Development and Therapy 2015, 9:1359-1366
Published Date: 5 March 2015
Clinicopathological significance of CXCR4 in non-small cell lung cancer
Zhou X, He L, Hou G, Jiang B, Wang Y, Zhao L
Drug Design, Development and Therapy 2015, 9:1349-1358
Published Date: 5 March 2015
The effect of ethanol sclerotherapy of 5 minutes duration on cyst diameter and rat ovarian tissue in simple ovarian cysts
Şimşek M, Kuloğlu T, Pala Ş, Boztosun A, Can B, Atilgan R
Drug Design, Development and Therapy 2015, 9:1341-1347
Published Date: 5 March 2015
Profile of atacicept and its potential in the treatment of systemic lupus erythematosus
Cogollo E, Silva MA, Isenberg D
Drug Design, Development and Therapy 2015, 9:1331-1339
Published Date: 5 March 2015
Antitumor activity of SA12, a novel peptide, on SKBr-3 breast cancer cells via the mitochondrial apoptosis pathway
Yang L, Cui Y, Shen J, Lin F, Wang X, Long M, Wei J, Zhang H
Drug Design, Development and Therapy 2015, 9:1319-1330
Published Date: 2 March 2015
Danusertib, a potent pan-Aurora kinase and ABL kinase inhibitor, induces cell cycle arrest and programmed cell death and inhibits epithelial to mesenchymal transition involving the PI3K/Akt/mTOR-mediated signaling pathway in human gastric cancer AGS and NCI-N78 cells
Yuan CX, Zhou ZW, Yang YX, He ZX, Zhang X, Wang D, Yang T, Pan SY, Chen XW, Zhou SF
Drug Design, Development and Therapy 2015, 9:1293-1318
Published Date: 2 March 2015
In vitro and in vivo anti-angiogenic activity of girinimbine isolated from Murraya koenigii
Iman V, Karimian H, Mohan S, Hobani YH, Noordin MI, Mustafa MR, Noor SM
Drug Design, Development and Therapy 2015, 9:1281-1292
Published Date: 3 March 2015
Antitumoral materials with regenerative function obtained using a layer-by-layer technique
Ficai D, Sonmez M, Albu MG, Mihaiescu DE, Ficai A, Bleotu C
Drug Design, Development and Therapy 2015, 9:1269-1279
Published Date: 2 March 2015
A phase 1 randomized study evaluating the effect of omeprazole on the pharmacokinetics of a novel 5-hydroxytryptamine receptor 4 agonist, revexepride (SSP-002358), in healthy adults
Pierce D, Corcoran M, Velinova M, Hossack S, Hoppenbrouwers M, Martin P
Drug Design, Development and Therapy 2015, 9:1257-1268
Published Date: 27 February 2015
Noncoding RNAs as potential biomarkers to predict the outcome in pancreatic cancer
Jin K, Luo G, Xiao Z, Liu Z, Liu C, Ji S, Xu J, Liu L, Long J, Ni Q, Yu X
Drug Design, Development and Therapy 2015, 9:1247-1255
Published Date: 26 February 2015
Pharmacokinetic-pharmacodynamic analysis to evaluate the effect of moxifloxacin on QT interval prolongation in healthy Korean male subjects
Hong T, Han S, Lee J, Jeon S, Park GJ, Park WS, Lim KS, Chung JY, Yu KS, Yim DS
Drug Design, Development and Therapy 2015, 9:1233-1245
Published Date: 26 February 2015
Fluorescence detection of tramadol in healthy Chinese volunteers by high-performance liquid chromatography and bioequivalence assessment
Zhou X, Liu J
Drug Design, Development and Therapy 2015, 9:1225-1231
Published Date: 26 February 2015
Advantageous effects of immunosuppression with tacrolimus in comparison with cyclosporine A regarding renal function in patients after heart transplantation
Helmschrott M, Rivinius R, Ruhparwar A, Schmack B, Erbel C, Gleissner CA, Akhavanpoor M, Frankenstein L, Ehlermann P, Bruckner T, Katus HA, Doesch AO
Drug Design, Development and Therapy 2015, 9:1217-1224
Published Date: 24 February 2015
Pharmacokinetic interaction between udenafil and dapoxetine: a randomized, open-labeled crossover study in healthy male volunteers
Kim YH, Choi HY, Lee SH, Jeon HS, Lim HS, Bahng MY, Bae KS
Drug Design, Development and Therapy 2015, 9:1209-1216
Published Date: 23 February 2015
Koenimbin, a natural dietary compound of Murraya koenigii (L) Spreng: inhibition of MCF7 breast cancer cells and targeting of derived MCF7 breast cancer stem cells (CD44+/CD24-/low): an in vitro study
Ahmadipour F, Noordin MI, Mohan S, Arya A, Paydar M, Looi CY, Keong YS, Siyamak EN, Fani S, Firoozi M, Yong CL, Sukari MA, Kamalidehghan B
Drug Design, Development and Therapy 2015, 9:1193-1208
Published Date: 24 February 2015
Electrochemotherapy in combination with chemoradiotherapy in the treatment of oral carcinomas in advanced stages of disease: efficacy, safety, and clinical outcomes in a small number of selected cases
Domanico R, Trapasso S, Santoro M, Pingitore D, Allegra E
Drug Design, Development and Therapy 2015, 9:1185-1191
Published Date: 19 February 2015
Liraglutide reduces lipogenetic signals in visceral adipose of db/db mice with AMPK activation and Akt suppression
Shao Y, Yuan G, Zhang J, Guo X
Drug Design, Development and Therapy 2015, 9:1177-1184
Published Date: 18 February 2015
Hsa-microRNA-181a is a regulator of a number of cancer genes and a biomarker for endometrial carcinoma in patients: a bioinformatic and clinical study and the therapeutic implication
He S, Zeng S, Zhou ZW, He ZX, Zhou SF
Drug Design, Development and Therapy 2015, 9:1103-1175
Published Date: 18 February 2015
A computational and functional study elicits the ameliorating effect of the Chinese herbal formula Huo Luo Xiao Ling Dan on experimental ischemia-induced myocardial injury in rats via inhibition of apoptosis
Han XD, Zhou ZW, Yang W, Ye HC, Xu YZ, Huang YF, Zhang T, Zhou SF
Drug Design, Development and Therapy 2015, 9:1063-1102
Published Date: 18 February 2015
The pan-inhibitor of Aurora kinases danusertib induces apoptosis and autophagy and suppresses epithelial-to-mesenchymal transition in human breast cancer cells
Li JP, Yang YX, Liu QL, Zhou ZW, Pan ST, He ZX, Zhang X, Yang T, Pan SY, Duan W, He SM, Chen XW, Qiu JX, Zhou SF
Drug Design, Development and Therapy 2015, 9:1027-1062
Published Date: 17 February 2015
Bardoxolone methyl induces apoptosis and autophagy and inhibits epithelial-to-mesenchymal transition and stemness in esophageal squamous cancer cells
Wang YY, Yang YX, Zhao R, Pan ST, Zhe H, He ZX, Duan W, Zhang X, Yang TX, Qiu JX, Zhou SF
Drug Design, Development and Therapy 2015, 9:993-1026
Published Date: 17 February 2015
Synthesis of an anthraquinone derivative (DHAQC) and its effect on induction of G2/M arrest and apoptosis in breast cancer MCF-7 cell line
Yeap SK, Akhtar MN, Lim KL, Abu N, Ho WY, Zareen S, Roohani K, Ky H, Tan SW, Lajis N, Alitheen NB
Drug Design, Development and Therapy 2015, 9:983-992
Published Date: 17 February 2015
1-1-12 one-step wash-in scheme for desflurane low flow anesthesia: performance without nitrous oxide
Sathitkarnmanee T, Tribuddharat S, Nonlhaopol D, Thananun M, Somdee W
Drug Design, Development and Therapy 2015, 9:977-981
Published Date: 17 February 2015
Human mesenchymal stem cells as delivery of osteoprotegerin gene: homing and therapeutic effect for osteosarcoma
Qiao B, Shui W, Cai L, Guo SQ, Jiang DM
Drug Design, Development and Therapy 2015, 9:969-976
Published Date: 17 February 2015
Proteomic response to 5,6-dimethylxanthenone 4-acetic acid (DMXAA, vadimezan) in human non-small cell lung cancer A549 cells determined by the stable-isotope labeling by amino acids in cell culture (SILAC) approach
Pan ST, Zhou ZW, He ZX, Zhang X, Yang T, Yang YX, Wang D, Qiu JX, Zhou SF
Drug Design, Development and Therapy 2015, 9:937-968
Published Date: 17 February 2015
Effects of combined dietary supplementation with fenofibrate and Schisandrae Fructus pulp on lipid and glucose levels and liver function in normal and hypercholesterolemic mice
Zhu PL, Pan SY, Zhou SF, Zhang Y, Wang XY, Sun N, Chu ZS, Yu ZL, Ko KM
Drug Design, Development and Therapy 2015, 9:923-935
Published Date: 17 February 2015
Design, synthesis, and computational studies on dihydropyrimidine scaffolds as potential lipoxygenase inhibitors and cancer chemopreventive agents
Venugopala KN, Govender R, Khedr MA, Venugopala R, Aldhubiab BE, Harsha S, Odhav B
Drug Design, Development and Therapy 2015, 9:911-921
Published Date: 17 February 2015
Upregulation of PD-L1 and APE1 is associated with tumorigenesis and poor prognosis of gastric cancer
Qing Y, Li Q, Ren T, Xia W, Peng Y, Liu GL, Luo H, Yang YX, Dai XY, Zhou SF, Wang D
Drug Design, Development and Therapy 2015, 9:901-909
Published Date: 16 February 2015
Treatment with a herbal formula B401 enhances neuroprotection and angiogenesis in the R6/2 mouse model of Huntington’s disease
Wang SE, Lin CL, Hsu CH, Sheu SJ, Chien CT, Wu CH
Drug Design, Development and Therapy 2015, 9:887-900
Published Date: 16 February 2015
Tazarotene as alternative topical treatment for onychomycosis
Campione E, Paternò EJ, Costanza G, Diluvio L, Carboni I, Marino D, Favalli C, Chimenti S, Bianchi L, Orlandi A
Drug Design, Development and Therapy 2015, 9:879-886
Published Date: 16 February 2015
Anesthetic drug midazolam inhibits cardiac human ether-à-go-go-related gene channels: mode of action
Vonderlin N, Fischer F, Zitron E, Seyler C, Scherer D, Thomas D, Katus HA, Scholz EP,
Drug Design, Development and Therapy 2015, 9:867-877
Published Date: 16 February 2015
Estimation of the binding modes with important human cytochrome P450 enzymes, drug interaction potential, pharmacokinetics, and hepatotoxicity of ginger components using molecular docking, computational, and pharmacokinetic modeling studies
Qiu JX, Zhou ZW, He ZX, Zhang X, Zhou SF, Zhu S
Drug Design, Development and Therapy 2015, 9:841-866
Published Date: 16 February 2015
In vivo determination of the diclofenac skin reservoir: comparison between passive, occlusive, and iontophoretic application
Clijsen R, Baeyens JP, Barel AO, Clarys P
Drug Design, Development and Therapy 2015, 9:835-840
Published Date: 13 February 2015
Recent advances in combinatorial biosynthesis for drug discovery
Sun H, Liu Z, Zhao H, Ang EL
Drug Design, Development and Therapy 2015, 9:823-833
Published Date: 12 February 2015
Development of a test for recording both visual and auditory reaction times, potentially useful for future studies in patients on opioids therapy
Miceli L, Bednarova R, Rizzardo A, Samogin V, Della Rocca G
Drug Design, Development and Therapy 2015, 9:817-822
Published Date: 12 February 2015
Borreliacidal activity of Borrelia metal transporter A (BmtA) binding small molecules by manganese transport inhibition
Wagh D, Pothineni VR, Inayathullah M, Liu S, Kim KM, Rajadas J
Drug Design, Development and Therapy 2015, 9:805-816
Published Date: 10 February 2015
Efficacy and safety of a herbal mixture (Viron® tablets) in the treatment of patients with chronic hepatitis C virus infection: a prospective, randomized, open-label, proof-of-concept study
Shawkat H, Yakoot M, Shawkat T, Helmy S
Drug Design, Development and Therapy 2015, 9:799-804
Published Date: 11 February 2015
Development of lovastatin-loaded poly(lactic acid) microspheres for sustained oral delivery: in vitro and ex vivo evaluation
Guan QG, Chen W, Hu XM
Drug Design, Development and Therapy 2015, 9:791-798
Published Date: 10 February 2015
Clinical utility of eslicarbazepine: current evidence
Zaccara G, Giovannelli F, Cincotta M, Carelli A, Verrotti A
Drug Design, Development and Therapy 2015, 9:781-789
Published Date: 10 February 2015
The role of dasatinib in the management of chronic myeloid leukemia
Chen R, Chen B
Drug Design, Development and Therapy 2015, 9:773-779
Published Date: 9 February 2015
Effect and mechanism of fluoxetine on electrophysiology in vivo in a rat model of postmyocardial infarction depression
Liang J, Yuan X, Shi S, Wang F, Chen Y, Qu C, Chen J, Hu D, Yang B
Drug Design, Development and Therapy 2015, 9:763-772
Published Date: 10 February 2015
Clinical pharmacokinetics of AZD3199, an inhaled ultra-long-acting β2-adrenoreceptor agonist (uLABA)
Bjermer L, Kuna P, Jorup C, Bengtsson T, Rosenborg J
Drug Design, Development and Therapy 2015, 9:753-762
Published Date: 5 February 2015
A pharmacokinetic and pharmacodynamic drug interaction between rosuvastatin and valsartan in healthy subjects
Jung JA, Lee SY, Kim JR, Ko JW, Jang SB, Nam SY, Huh W
Drug Design, Development and Therapy 2015, 9:745-752
Published Date: 2 March 2015
Lack of the effect of lobeglitazone, a peroxisome proliferator-activated receptor-γ agonist, on the pharmacokinetics and pharmacodynamics of warfarin
Jung JA, Lee SY, Kim TE, Kim JR, Kim C, Huh W, Ko JW
Drug Design, Development and Therapy 2015, 9:737-743
Published Date: 2 March 2015
A fixed-dose combination tablet of gemigliptin and metformin sustained release has comparable pharmacodynamic, pharmacokinetic, and tolerability profiles to separate tablets in healthy subjects
Park SI, Lee H, Oh J, Lim KS, Jang IJ, Kim JA, Jung JH, Yu KS
Drug Design, Development and Therapy 2015, 9:729-736
Published Date: 4 February 2015
Treatment of alarming head and neck infantile hemangiomas with interferon-α2a: a clinical study in eleven consecutive patients
Zhang L, Zheng JW, Yuan WE
Drug Design, Development and Therapy 2015, 9:723-727
Published Date: 4 February 2015
Urine metabolomics in rats after administration of ketamine
Wen C, Zhang M, Ma J, Hu L, Wang X, Lin G
Drug Design, Development and Therapy 2015, 9:717-722
Published Date: 3 February 2015
Steroid for epidural injection in spinal stenosis: a systematic review and meta-analysis
Liu K, Liu PC, Liu R, Wu X, Cai M
Drug Design, Development and Therapy 2015, 9:707-716
Published Date: 30 January 2015
Design and in vivo evaluation of oxycodone once-a-day controlled-release tablets
Kim JY, Lee SH, Park CW, Rhee YS, Kim DW, Park J, Lee M, Seo JW, Park ES
Drug Design, Development and Therapy 2015, 9:695-706
Published Date: 30 January 2015
Sodium hyaluronate eye drops treatment for superficial corneal abrasion caused by mechanical damage: a randomized clinical trial in the People’s Republic of China
Lin T, Gong L
Drug Design, Development and Therapy 2015, 9:687-694
Published Date: 30 January 2015
Emerging options for the treatment of type 2 diabetes in Chinese patients: focus on arterial function and alogliptin
Wang H, Liu J, Zhao H
Drug Design, Development and Therapy 2015, 9:683-686
Published Date: 30 January 2015
Profile of delamanid for the treatment of multidrug-resistant tuberculosis
Szumowski JD, Lynch JB
Drug Design, Development and Therapy 2015, 9:677-682
Published Date: 29 January 2015
Apparent histological changes of adipocytes after treatment with CL 316,243, a ß-3-adrenergic receptor agonist
Ghorbani M, Teimourian S, Farzad R, Asl NN
Drug Design, Development and Therapy 2015, 9:669-676
Published Date: 11 February 2015
Antiaging therapy: a prospective hypothesis
Shahidi Bonjar MR, Shahidi Bonjar L
Drug Design, Development and Therapy 2015, 9:663-667
Published Date: 28 January 2015
Optimization of caseinate-coated simvastatin-zein nanoparticles: improved bioavailability and modified release characteristics
Ahmed OA, Hosny KM, Al-Sawahli MM, Fahmy UA
Drug Design, Development and Therapy 2015, 9:655-662
Published Date: 23 January 2015
Organic anion transporter 3- and organic anion transporting polypeptides 1B1- and 1B3-mediated transport of catalposide
Jeong HU, Kwon M, Lee Y, Yoo JS, Shin DH, Song IS, Lee HS
Drug Design, Development and Therapy 2015, 9:643-653
Published Date: 22 January 2015
Development of intramammary delivery systems containing lasalocid for the treatment of bovine mastitis: impact of solubility improvement on safety, efficacy, and milk distribution in dairy cattle
Wang W, Song Y, Petrovski K, Eats P, Trott DJ, Wong HS, Page SW, Perry J, Garg S
Drug Design, Development and Therapy 2015, 9:631-642
Published Date: 22 January 2015
Design of a new therapy for patients with chronic kidney disease: use of microarrays for selective hemoadsorption of uremic wastes and toxins to improve homeostasis
Shahidi Bonjar MR, Shahidi Bonjar L
Drug Design, Development and Therapy 2015, 9:625-629
Published Date: 19 January 2015
Altered γ-aminobutyric acid neurotransmission in major depressive disorder: a critical review of the supporting evidence and the influence of serotonergic antidepressants
Pehrson AL, Sanchez C
Drug Design, Development and Therapy 2015, 9:603-624
Published Date: 19 January 2015
Alisertib induces cell cycle arrest and autophagy and suppresses epithelial-to-mesenchymal transition involving PI3K/Akt/mTOR and sirtuin 1-mediated signaling pathways in human pancreatic cancer cells
Wang F, Li H, Yan XG, Zhou ZW, Yi ZG, He ZX, Pan ST, Yang YX, Wang ZZ, Zhang X, Yang T, Qiu JX, Zhou SF
Drug Design, Development and Therapy 2015, 9:575-601
Published Date: 17 January 2015
Combination therapy of ursodeoxycholic acid and budesonide for PBC–AIH overlap syndrome: a meta-analysis
Zhang H, Yang J, Zhu R, Zheng Y, Zhou Y, Dai W, Wang F, Chen K, Li J, Wang C, Li S, Liu T, Abudumijiti H, Zhou Z, Wang J, Lu W, Wang J, Xia Y, Zhou Y, Lu J, Guo C
Drug Design, Development and Therapy 2015, 9:567-574
Published Date: 17 January 2015
Stability of refrigerated miglustat after preparation in InOrpha® flavored suspending excipient for compounding of oral solutions and suspensions
Riahi S, Ambühl M, Stichler J, Bandilla D
Drug Design, Development and Therapy 2015, 9:561-566
Published Date: 17 January 2015
Plumbagin induces cell cycle arrest and autophagy and suppresses epithelial to mesenchymal transition involving PI3K/Akt/mTOR-mediated pathway in human pancreatic cancer cells
Wang F, Wang Q, Zhou ZW, Yu SN, Pan ST, He ZX, Zhang X, Wang D, Yang YX, Yang T, Sun T, Li M, Qiu JX, Zhou SF
Drug Design, Development and Therapy 2015, 9:537-560
Published Date: 17 January 2015
Rare sugar D-psicose prevents progression and development of diabetes in T2DM model Otsuka Long-Evans Tokushima Fatty rats
Hossain A, Yamaguchi F, Hirose K, Matsunaga T, Sui L, Hirata Y, Noguchi C, Katagi A, Kamitori K, Dong Y, Tsukamoto I, Tokuda M
Drug Design, Development and Therapy 2015, 9:525-535
Published Date: 17 January 2015
Assessment of prescribing, dispensing, and patient use pattern of antihypertensive drugs for patients attending outpatient department of Hiwot Fana Specialized University Hospital, Harar, Eastern Ethiopia
Shukrala F, Gabriel T
Drug Design, Development and Therapy 2015, 9:519-523
Published Date: 17 January 2015
HMG-CoA reductase inhibitory activity and phytocomponent investigation of Basella alba leaf extract as a treatment for hypercholesterolemia
Baskaran G, Salvamani S, Ahmad SA, Shaharuddin NA, Pattiram PD, Shukor MY
Drug Design, Development and Therapy 2015, 9:509-517
Published Date: 14 January 2015
Inhibition of mitotic Aurora kinase A by alisertib induces apoptosis and autophagy of human gastric cancer AGS and NCI-N78 cells
Yuan CX, Zhou ZW, Yang YX, He ZX, Zhang X, Wang D, Yang T, Wang NJ, Zhao RJ, Zhou SF
Drug Design, Development and Therapy 2015, 9:487-508
Published Date: 14 January 2015
Tacrolimus in preventing transplant rejection in Chinese patients – optimizing use
Li CJ, Li L
Drug Design, Development and Therapy 2015, 9:473-485
Published Date: 13 January 2015
Soy polysaccharide as a novel superdisintegrant in sildenafil citrate sublingual tablets: preparation, characterization, and in vivo evaluation
Hosny KM, Mosli HA, Hassan AH
Drug Design, Development and Therapy 2015, 9:465-472
Published Date: 12 January 2015
Alisertib, an Aurora kinase A inhibitor, induces apoptosis and autophagy but inhibits epithelial to mesenchymal transition in human epithelial ovarian cancer cells
Ding YH, Zhou ZW, Ha CF, Zhang XY, Pan ST, He ZX, Edelman JL, Wang D, Yang ZX, Zhang XJ, Duan W, Yang TX, Qiu JX, Zhou SF
Drug Design, Development and Therapy 2015, 9:425-464
Published Date: 9 January 2015
Letter to the editor: naltrexone sustained-release/bupropion sustained-release for the management of obesity: review of the data to date
Buehler AM
Drug Design, Development and Therapy 2015, 9:419-423
Published Date: 8 January 2015
Plumbagin elicits differential proteomic responses mainly involving cell cycle, apoptosis, autophagy, and epithelial-to-mesenchymal transition pathways in human prostate cancer PC-3 and DU145 cells
Qui JX, Zhou ZW, He ZX, Zhao RJ, Zhang X, Yang L, Zhou SF, Mao ZF
Drug Design, Development and Therapy 2015, 9:349-417
Published Date: 7 January 2015
Current and emerging treatment options for ANCA-associated vasculitis: potential role of belimumab and other BAFF/APRIL targeting agents
Lenert A, Lenert P
Drug Design, Development and Therapy 2015, 9:333-347
Published Date: 7 January 2015
Screening strategies to identify HSP70 modulators to treat Alzheimer’s disease
Repalli J, Meruelo D
Drug Design, Development and Therapy 2015, 9:321-331
Published Date: 7 January 2015
Solid lipid nanoparticles loaded with iron to overcome barriers for treatment of iron deficiency anemia
Hosny KM, Banjar ZM, Hariri AH, Hassan AH
Drug Design, Development and Therapy 2015, 9:313-320
Published Date: 8 January 2015
Sample sizes in dosage investigational clinical trials: a systematic evaluation
Huang JH, Su QM, Yang J, Lv YH, He YC, Chen JC, Xu L, Wang K, Zheng QS
Drug Design, Development and Therapy 2015, 9:305-312
Published Date: 7 January 2015
Vipegitide: a folded peptidomimetic partial antagonist of α2β1 integrin with antiplatelet aggregation activity
Momic T, Katzhendler J, Shai E, Noy E, Senderowitz H, Eble JA, Marcinkiewicz C, Varon D, Lazarovici P
Drug Design, Development and Therapy 2015, 9:291-304
Published Date: 5 January 2015
Comparison of peginterferon alfa-2a and alfa-2b for treatment of patients with chronic hepatitis C:a retrospective study using the Japanese Interferon Database
Sato I, Shimbo T, Kawasaki Y, Masaki N
Drug Design, Development and Therapy 2015, 9:283-290
Published Date: 30 December 2014
Nanoparticle formulation by Büchi B-90 Nano Spray Dryer for oral mucoadhesion
Harsha SN, Aldhubiab BE, Nair AB, Alhaider IA, Attimarad M, Venugopala KN, Srinivasan S, Gangadhar N, Asif AH
Drug Design, Development and Therapy 2015, 9:273-282
Published Date: 23 January 2015
RETRACTED ARTICLE: Coffee and caffeine potentiate the antiamyloidogenic activity of melatonin via inhibition of Aβ oligomerization and modulation of the Tau-mediated pathway in N2a/APP cells
Zhang LF, Zhou ZW, Wang ZH, Du YH, He ZX, Cao CH, Zhou SF
Drug Design, Development and Therapy 2015, 9:241-272
Published Date: 24 December 2014
Synthesis and characterization of a novel chemically designed (Globo)3–DTPA–KLH antigen
Hajmohammadi M, Siadat SD, Ghorbani M, Shafiee Ardestani M, Teimourian S, Asgari V, Ahangari Cohan R, Hajmohammadi M, Hajmohammadi A, Behzadi R, Rajabnezhad S, Namvar Asl N
Drug Design, Development and Therapy 2015, 9:217-239
Published Date: 22 December 2014
Clinicopathological significance and potential drug target of T-cadherin in NSCLC
Wang Z, Wang B, Guo H, Shi G, Hong X
Drug Design, Development and Therapy 2015, 9:207-216
Published Date: 19 December 2014
Postsynaptic density protein 95-regulated NR2B tyrosine phosphorylation and interactions of Fyn with NR2B in levodopa-induced dyskinesia rat models
Ba M, Kong M, Ma G
Drug Design, Development and Therapy 2015, 9:199-206
Published Date: 19 December 2014
Glycyrrhetinic acid and E.resveratroloside act as potential plant derived compounds against dopamine receptor D3 for Parkinson’s disease: a pharmacoinformatics study
Mirza MU, Mirza AH, Ghori NUH, Ferdous S
Drug Design, Development and Therapy 2015, 9:187-198
Published Date: 18 December 2014
A thorough QT study in the context of an uptitration regimen with selexipag, a selective oral prostacyclin receptor agonist
Hoch M, Darpo B, Remenova T, Stoltz R, Zhou M, Kaufmann P, Bruderer S, Dingemanse J
Drug Design, Development and Therapy 2015, 9:175-185
Published Date: 17 December 2014
Clinical effect of a positive surgical margin after hepatectomy on survival of patients with intrahepatic cholangiocarcinoma
Yeh CN, Hsieh FJ, Chiang KC, Chen JS, Yeh TS, Jan YY, Chen MF
Drug Design, Development and Therapy 2015, 9:163-174
Published Date: 17 December 2014
Profile of netupitant/palonosetron (NEPA) fixed dose combination and its potential in the treatment of chemotherapy-induced nausea and vomiting (CINV)
Navari RM
Drug Design, Development and Therapy 2015, 9:155-161
Published Date: 17 December 2014
Designing biologic selectivity for inflammatory bowel disease – role of vedolizumab
Krupka N, Baumgart DC
Drug Design, Development and Therapy 2015, 9:147-154
Published Date: 17 December 2014
Schisandra chinensis regulates drug metabolizing enzymes and drug transporters via activation of Nrf2-mediated signaling pathway
He JL, Zhou ZW, Yin JJ, He CQ, Zhou SF, Yu Y
Drug Design, Development and Therapy 2015, 9:127-146
Published Date: 17 December 2014
Pharmacological approaches to improving cognitive function in Down syndrome: current status and considerations
Gardiner KJ
Drug Design, Development and Therapy 2015, 9:103-125
Published Date: 17 December 2014
Analysis of malignancies in patients after heart transplantation with subsequent immunosuppressive therapy
Rivinius R, Helmschrott M, Ruhparwar A, Schmack B, Klein B, Erbel C, Gleissner CA, Akhavanpoor M, Frankenstein L, Darche FF, Thomas D, Ehlermann P, Bruckner T, Katus HA, Doesch AO
Drug Design, Development and Therapy 2015, 9:93-102
Published Date: 17 December 2014
Arsenic sulfide, the main component of realgar, a traditional Chinese medicine, induces apoptosis of gastric cancer cells in vitro and in vivo
Zhang L, Tian W, Kim S, Ding W, Tong Y, Chen S
Drug Design, Development and Therapy 2015, 9:79-92
Published Date: 16 December 2014
An evidence-based update on the pharmacological activities and possible molecular targets of Lycium barbarum polysaccharides
Cheng J, Zhou ZW, Sheng HP, He LJ, Fan XW, He ZX, Sun T, Zhang X, Zhao RJ, Gu L, Cao CH, Zhou SF
Drug Design, Development and Therapy 2015, 9:33-78
Published Date: 17 December 2014
Microemulsion of babassu oil as a natural product to improve human immune system function
Pessoa RS, França EL, Ribeiro EB, Lanes PK, Chaud NG, Moraes LC, Honorio-França AC
Drug Design, Development and Therapy 2015, 9:21-31
Published Date: 16 December 2014
Temsirolimus for patients with metastatic renal cell carcinoma: outcomes in patients receiving temsirolimus within a compassionate use program in a tertiary referral center
Afshar M, Pascoe J, Whitmarsh S, James N, Porfiri E
Drug Design, Development and Therapy 2015, 9:13-19
Published Date: 17 December 2014
Impact of crystal polymorphism on the systemic bioavailability of rifaximin, an antibiotic acting locally in the gastrointestinal tract, in healthy volunteers
Blandizzi C, Viscomi GC, Scarpignato C
Drug Design, Development and Therapy 2015, 9:1-11
Published Date: 16 December 2014