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Drug Design, Development and Therapy


Archive: Volume 13, 2019

Radioprotective Potential of Sulindac Sulfide to Prevent DNA Damage Due to Ionizing Radiation

Torabizadeh SA, Rezaeifar M, Jomehzadeh A, Nabizadeh Haghighi F, Ansari M

Drug Design, Development and Therapy 2019, 13:4127-4134

Published Date: 6 December 2019

Efficacy and Safety of Combined Vitrectomy with Intravitreal Dexamethasone Implant for Advanced Stage Epiretinal Membrane

Iovino C, Giannaccare G, Pellegrini M, Bernabei F, Braghiroli M, Caporossi T, Peiretti E

Drug Design, Development and Therapy 2019, 13:4107-4114

Published Date: 3 December 2019

Profile of Tofacitinib in the Treatment of Ulcerative Colitis: An Evidence-Based Review of Recent Data

Varyani F, Argyriou K, Phillips F, Tsakiridou E, Moran GW

Drug Design, Development and Therapy 2019, 13:4091-4105

Published Date: 2 December 2019

Liraglutide Improves Non-Alcoholic Fatty Liver Disease In Diabetic Mice By Modulating Inflammatory Signaling Pathways

Luo Y, Yang P, Li Z, Luo Y, Shen J, Li R, Zheng H, Liang Y, Xia N

Drug Design, Development and Therapy 2019, 13:4065-4074

Published Date: 2 December 2019

Delivery Of Curcumin Nanoliposomes Using Surface Modified With CD133 Aptamers For Prostate Cancer

Ma Q, Qian W, Tao W, Zhou Y, Xue B

Drug Design, Development and Therapy 2019, 13:4021-4033

Published Date: 28 November 2019

Transformation of Meloxicam Containing Nanosuspension into Surfactant-Free Solid Compositions to Increase the Product Stability and Drug Bioavailability for Rapid Analgesia

Bartos C, Ambrus R, Katona G, Sovány T, Gáspár R, Márki Á, Ducza E, Ivanov A, Tömösi F, Janáky T, Szabó-Révész P

Drug Design, Development and Therapy 2019, 13:4007-4020

Published Date: 28 November 2019

A Network Pharmacology-Based Strategy For Predicting Active Ingredients And Potential Targets Of LiuWei DiHuang Pill In Treating Type 2 Diabetes Mellitus

He D, Huang JH, Zhang ZY, Du Q, Peng WJ, Yu R, Zhang SF, Zhang SH, Qin YH

Drug Design, Development and Therapy 2019, 13:3989-4005

Published Date: 28 November 2019

Postconditioning Protection Against Myocardiocyte Anoxia/Reoxygenation Injury From Penehyclidine Hydrochloride

Ren JY, Lin DM, Wang CB, Yang YL, Wang ZQ, Cui BQ, Ma J

Drug Design, Development and Therapy 2019, 13:3977-3988

Published Date: 26 November 2019

Effects Of Triptolide On Tooth Movement And Root Resorption In Rats

Yang F, Wang XX, Ma D, Cui Q, Zheng DH, Liu XC, Zhang J

Drug Design, Development and Therapy 2019, 13:3963-3975

Published Date: 25 November 2019

Icariin Alleviates IL-1β-Induced Matrix Degradation By Activating The Nrf2/ARE Pathway In Human Chondrocytes

Zuo S, Zou W, Wu RM, Yang J, Fan JN, Zhao XK, Li HY

Drug Design, Development and Therapy 2019, 13:3949-3961

Published Date: 21 November 2019

Alteration of Amino Acid Profiling Influenced by the Active Ingredients of DanHong Injection After Prescription Optimization

Guo Z, Zhu Y, Xu W, Luo K, Xiao H, Wang Z

Drug Design, Development and Therapy 2019, 13:3939-3947

Published Date: 21 November 2019

Assessment Of Spanlastic Vesicles Of Zolmitriptan For Treating Migraine In Rats

El-Nabarawy NA, Teaima MH, Helal DA

Drug Design, Development and Therapy 2019, 13:3929-3937

Published Date: 21 November 2019

The Effects Of Sevoflurane On The Progression And Cisplatinum Sensitivity Of Cervical Cancer Cells

Xue F, Xu Y, Song Y, Zhang W, Li R, Zhu X

Drug Design, Development and Therapy 2019, 13:3919-3928

Published Date: 18 November 2019

Efficacy And Safety Of Apatinib Treatment In Platinum-Resistant Recurrent Epithelial Ovarian Cancer: A Real World Study

Zhang J, Li A, Jiang Q, Zheng F, Zhu H

Drug Design, Development and Therapy 2019, 13:3913-3918

Published Date: 15 November 2019

Hesperidin: A Therapeutic Agent For Obesity

Xiong H, Wang J, Ran Q, Lou G, Peng C, Gan Q, Hu J, Sun J, Yao R, Huang Q

Drug Design, Development and Therapy 2019, 13:3855-3866

Published Date: 12 November 2019

Safety, pharmacokinetics and pharmacodynamics of the selective glucocorticoid receptor modulator AZD7594, following inhalation in healthy Japanese volunteers

Prothon S, Wählby Hamrén U, Tehler U, Yoon E, Forsman H, Arfvidsson C, Aggarwal A, Chen Y

Drug Design, Development and Therapy 2019, 13:3845-3853

Published Date: 12 November 2019

Comparing The Efficacy Of An Anti-Human VEGF-A Neutralizing Antibody Versus Bevacizumab On A Laser-Induced Choroidal Neovascularization (CNV) Rhesus Monkey Model

Olvera-Montaño O, Baiza-Duran L, Quintana-Hau JD, Quiñonez-Alvarado MG, Zeng W, Gong L, Muñoz-Villegas P

Drug Design, Development and Therapy 2019, 13:3813-3821

Published Date: 4 November 2019

Smart Targeting To Improve Cancer Therapeutics

Morales-Cruz M, Delgado Y, Castillo B, Figueroa CM, Molina AM, Torres A, Milián M, Griebenow K

Drug Design, Development and Therapy 2019, 13:3753-3772

Published Date: 30 October 2019

Baseline Lymphopenia: A Predictor Of Poor Outcomes In HER2 positive Metastatic Breast Cancer Treated With Trastuzumab

Che YQ, Zhang Y, Wang D, Liu HY, Shen D, Luo Y

Drug Design, Development and Therapy 2019, 13:3727-3734

Published Date: 29 October 2019

miR- 26a Sensitizes Melanoma Cells To Dabrafenib Via Targeting HMGB1-Dependent Autophagy Pathways

Yu Y, Xiang N, Lin M, Huang JW, Zhang J, Cheng B, Ji C

Drug Design, Development and Therapy 2019, 13:3717-3726

Published Date: 29 October 2019

Cardio- Renal Outcomes With Long- Term Agalsidase Alfa Enzyme Replacement Therapy: A 10- Year Fabry Outcome Survey (FOS) Analysis

Ramaswami U, Beck M, Hughes D, Kampmann C, Botha J, Pintos-Morell G, West ML, Niu DM, Nicholls K, Giugliani R

Drug Design, Development and Therapy 2019, 13:3705-3715

Published Date: 25 October 2019

Exosomes Derived From Bone Marrow Mesenchymal Stem Cells Inhibit Complement Activation In Rats With Spinal Cord Injury

Zhao C, Zhou X, Qiu J, Xin D, Li T, Chu X, Yuan H, Wang H, Wang Z, Wang D

Drug Design, Development and Therapy 2019, 13:3693-3704

Published Date: 24 October 2019

Glucoside Derivatives Of Podophyllotoxin: Synthesis, Physicochemical Properties, And Cytotoxicity

Zi CT, Yang L, Kong QH, Li HM, Yang XZ, Ding ZT, Jiang ZH, Hu JM, Zhou J

Drug Design, Development and Therapy 2019, 13:3683-3692

Published Date: 23 October 2019

Olmesartan Medoxomil, An Angiotensin II-Receptor Blocker, Ameliorates Renal Injury In db/db Mice

Zhu Y, Li ZL, Ding A, Yang H, Zhu WP, Cui TX, Zhang HT, Zhang H

Drug Design, Development and Therapy 2019, 13:3657-3667

Published Date: 22 October 2019

The Effect Of Food On The Pharmacokinetic Properties And Bioequivalence Of Two Formulations Of Levocetirizine Dihydrochloride In Healthy Chinese Volunteers

Cheng Y, Lin BJ, Guo JH, Huang BL, Fang LP, Que WC, Liu MB, Chen XF, Qiu HQ

Drug Design, Development and Therapy 2019, 13:3625-3634

Published Date: 18 October 2019

In-vitro blood-brain barrier models for drug screening and permeation studies: an overview

Bagchi S, Chhibber T, Lahooti B, Verma A, Borse V, Jayant RD

Drug Design, Development and Therapy 2019, 13:3591-3605

Published Date: 18 October 2019

Diammonium Glycyrrhizinate Mitigates Liver Injury Via Inhibiting Proliferation Of NKT Cells And Promoting Proliferation Of Tregs

Gao M, Li X, He L, Yang J, Ye X, Xiao F, Wei H

Drug Design, Development and Therapy 2019, 13:3579-3589

Published Date: 16 October 2019

Indole-2-Carboxamide Derivative LG25 Inhibits Triple-Negative Breast Cancer Growth By Suppressing Akt/mTOR/NF-κB Signalling Pathway

Xu X, Rajamanickam V, Shu S, Liu Z, Yan T, He J, Liu Z, Guo G, Liang G, Wang Y

Drug Design, Development and Therapy 2019, 13:3539-3550

Published Date: 11 October 2019

Aucubin Protects Chondrocytes Against IL-1β-Induced Apoptosis In Vitro And Inhibits Osteoarthritis In Mice Model

Wang B, Jiang Y, Yao Z, Chen P, Yu B, Wang S

Drug Design, Development and Therapy 2019, 13:3529-3538

Published Date: 9 October 2019

20(S)-Ginsenoside Rg3 Promotes Senescence And Apoptosis In Gallbladder Cancer Cells Via The P53 Pathway [Corrigendum]

Zhang F, Li M, Wu X, Hu Y, Cao Y, Wang X, Xiang S, Li H, Jiang L, Tan Z, Lu W, Weng H, Shu Y, Gong W, Wang X, Zhang Y, Shi W, Dong P, Gu J, Liu Y

Drug Design, Development and Therapy 2019, 13:3527-3528

Published Date: 8 October 2019

Thrombospondin-1 Serum Levels In Hypertensive Patients With Endothelial Dysfunction After One Year Of Treatment With Perindopril

Buda V, Andor M, Cristescu C, Tomescu MC, Muntean DM, Bâibâță DE, Bordejevic DA, Danciu C, Dalleur O, Coricovac D, Crainiceanu Z, Tudor A, Ledeti I, Petrescu L

Drug Design, Development and Therapy 2019, 13:3515-3526

Published Date: 8 October 2019

The Osteoprotective Effects Of Kaempferol: The Evidence From In Vivo And In Vitro Studies

Wong SK, Chin KY, Ima-Nirwana S

Drug Design, Development and Therapy 2019, 13:3497-3514

Published Date: 7 October 2019

Enzyme Inhibitory, Antioxidant And Antibacterial Potentials Of Synthetic Symmetrical And Unsymmetrical Thioureas

Naz S, Zahoor M, Umar MN, Ali B, Ullah R, Shahat AA, Mahmood HM, Sahibzada MUK

Drug Design, Development and Therapy 2019, 13:3485-3495

Published Date: 7 October 2019

Dexmedetomidine Attenuates Neuroinflammation In LPS-Stimulated BV2 Microglia Cells Through Upregulation Of miR-340

Bao Y, Zhu Y, He G, Ni H, Liu C, Ma L, Zhang L, Shi D

Drug Design, Development and Therapy 2019, 13:3465-3475

Published Date: 3 October 2019

Efficacy, Safety And Feasibility Of Antiemetic Prophylaxis With Fosaprepitant, Granisetron And Dexamethasone In Pediatric Patients With Hemato-Oncological Malignancies

Cabanillas Stanchi KM, Ebinger M, Hartmann U, Queudeville M, Feucht J, Ost M, Koch MS, Malaval C, Mezger M, Schober S, Weber S, Michaelis S, Lange V, Lang P, Handgretinger R, Döring M

Drug Design, Development and Therapy 2019, 13:3439-3451

Published Date: 30 September 2019

The Efficacy And Safety Of Apatinib Treatment For Patients With Metastatic Or Recurrent Cervical Cancer: A Retrospective Study

Yu J, Xu Z, Li A, Zhang J, Wang Y, Zhao H, Zhu H

Drug Design, Development and Therapy 2019, 13:3419-3424

Published Date: 26 September 2019

Hydrogels For Peptide Hormones Delivery: Therapeutic And Tissue Engineering Applications

Doostmohammadi M, Ameri A, Mohammadinejad R, Dehghannoudeh N, Banat IM, Ohadi M, Dehghannoudeh G

Drug Design, Development and Therapy 2019, 13:3405-3418

Published Date: 26 September 2019

Paclitaxel alleviated sepsis-induced acute lung injury by activating MUC1 and suppressing TLR-4/NF-κB pathway

Wang YM, Ji R, Chen WW, Huang SW, Zheng YJ, Yang ZT, Qu HP, Chen H, Mao EQ, Chen Y, Chen EZ

Drug Design, Development and Therapy 2019, 13:3391-3404

Published Date: 24 September 2019

Design, Synthesis, And Evaluation Of Cyanopyridines As Anti-Colorectal Cancer Agents Via Inhibiting STAT3 Pathway

Xu L, Shi L, Qiu S, Chen S, Lin M, Xiang Y, Zhao C, Zhu J, Shen L, Zuo Z

Drug Design, Development and Therapy 2019, 13:3369-3381

Published Date: 24 September 2019

Effects of loratadine, a histamine H1 receptor antagonist, on the skeletal system of young male rats

Folwarczna J, Konarek N, Freier K, Karbowniczek D, Londzin P, Janas A

Drug Design, Development and Therapy 2019, 13:3357-3367

Published Date: 23 September 2019

Effect Of Chinese Herb Danzhi Xiaoyao Pills On Pharmacokinetics Of Venlafaxine In Beagles

Zhu Y, Li S, Chen K, Ma K, Wu D, Qiu X

Drug Design, Development and Therapy 2019, 13:3343-3355

Published Date: 20 September 2019

Bioequivalence Study Of A Fixed-Dose Combination Tablet Containing Melitracen 10 mg And Flupentixol 0.5 mg In Healthy Chinese Volunteers Under Fasted And Fed Conditions

Wu L, Xu C, Wu G, Zhou H, Lv D, Zhai Y, Huang Y, Tang W, Li F, Shentu J

Drug Design, Development and Therapy 2019, 13:3331-3342

Published Date: 19 September 2019

Effects of quercetin, sitagliptin alone or in combination in testicular toxicity induced by doxorubicin in rats

Ahmed ZA, Abtar AN, Othman HH, Aziz TA

Drug Design, Development and Therapy 2019, 13:3321-3329

Published Date: 20 September 2019

Muscone Promotes The Adipogenic Differentiation Of Human Gingival Mesenchymal Stem Cells By Inhibiting The Wnt/β-Catenin Signaling Pathway

Yuan WX, Wang XX, Zheng DH, Ma D, Cui Q, Yang F, Zhang J

Drug Design, Development and Therapy 2019, 13:3291-3306

Published Date: 18 September 2019

A novel curcumin-loaded composite dressing facilitates wound healing due to its natural antioxidant effect

Zhao Y, Dai C, Wang Z, Chen W, Liu J, Zhuo R, Yu A, Huang S

Drug Design, Development and Therapy 2019, 13:3269-3280

Published Date: 16 September 2019

Carbocisteine inhibits the expression of Muc5b in COPD mouse model

Song Y, Wang W, Xie Y, Xiang B, Huang X, Guan W, Zheng J

Drug Design, Development and Therapy 2019, 13:3259-3268

Published Date: 16 September 2019

Identification of substandard drug products using electronic tongue: cefdinir suspension as a pilot example

Abu-Khalaf N, Zaid AN, Jaradat N, Alkilany AM, Abulateefeh SR, Al Ramahi R, Ghanem M

Drug Design, Development and Therapy 2019, 13:3249-3258

Published Date: 16 September 2019

Preclinical pharmacodynamic and pharmacokinetic characterization of the major metabolites of cariprazine

Kiss B, Némethy Z, Fazekas K, Kurkó D, Gyertyán I, Sághy K, Laszlovszky I, Farkas B, Kirschner N, Bolf-Terjéki E, Balázs O, Lendvai B

Drug Design, Development and Therapy 2019, 13:3229-3248

Published Date: 16 September 2019

Ubenimex induces apoptotic and autophagic cell death in rat GH3 and MMQ cells through the ROS/ERK pathway

Wang Y, Pang B, Zhang R, Fu Y, Pang Q

Drug Design, Development and Therapy 2019, 13:3217-3228

Published Date: 12 September 2019

Palliative chemotherapy with or without anti-EGFR therapy for de novo metastatic nasopharyngeal carcinoma: a propensity score-matching study

Sun XS, Liang YJ, Li XY, Liu SL, Chen QY, Tang LQ, Mai HQ

Drug Design, Development and Therapy 2019, 13:3207-3216

Published Date: 10 September 2019

Downregulation of p66Shc can reduce oxidative stress and apoptosis in oxidative stress model of marginal cells of stria vascularis in Sprague Dawley rats

Hao C, Wu X, Zhou R, Zhang H, Zhou Y, Wang X, Feng Y, Mei L, He C, Cai X, Wu L

Drug Design, Development and Therapy 2019, 13:3199-3206

Published Date: 10 September 2019

Omalizumab for chronic spontaneous urticaria in “complex” patients: data from real-life clinical practice

Vollono L, Piccolo A, Lanna C, Esposito M, Bavetta M, Campione E, Bianchi L, Diluvio L

Drug Design, Development and Therapy 2019, 13:3181-3186

Published Date: 6 September 2019

Emodin-induced autophagy against cell apoptosis through the PI3K/AKT/mTOR pathway in human hepatocytes

Zheng X, Yang S, Zhang R, Wang S, Li G, Zhou S

Drug Design, Development and Therapy 2019, 13:3171-3180

Published Date: 3 September 2019

Mifepristone inhibits IGF-1 signaling pathway in the treatment of uterine leiomyomas

Shen Q, Zou S, Sheng B, Zhao M, Sun LZ, Zhu X

Drug Design, Development and Therapy 2019, 13:3161-3170

Published Date: 3 September 2019

Dexmedetomidine protects H9c2 cardiomyocytes against oxygen-glucose deprivation/reoxygenation-induced intracellular calcium overload and apoptosis through regulating FKBP12.6/RyR2 signaling

Yuan M, Meng XW, Ma J, Liu H, Song SY, Chen QC, Liu HY, Zhang J, Song N, Ji FH, Peng K

Drug Design, Development and Therapy 2019, 13:3137-3149

Published Date: 2 September 2019

Pharmacokinetic and bioequivalence study between two formulations of S-1 in Korean gastric cancer patients

Lee HW, Seong SJ, Kang WY, Ohk B, Gwon MR, Kim BK, Cho S, Cho K, Sung YK, Yoon YR, Kim JG

Drug Design, Development and Therapy 2019, 13:3127-3136

Published Date: 3 September 2019

Silibinin attenuates high-fat diet-induced renal fibrosis of diabetic nephropathy

Liu K, Zhou S, Liu J, Wang Y, Zhu F, Liu M

Drug Design, Development and Therapy 2019, 13:3117-3126

Published Date: 29 August 2019

Therapeutic potential of BLT1 antagonist for COPD: involvement of inducing autophagy and ameliorating inflammation

Zhang L, Huang J, Dong R, Feng Y, Zhou M

Drug Design, Development and Therapy 2019, 13:3105-3116

Published Date: 4 September 2019

Polyphyllin VI induces apoptosis and autophagy in human osteosarcoma cells by modulation of ROS/JNK activation

Yuan YL, Jiang N, Li ZY, Song ZZ, Yang ZH, Xue WH, Zhang XJ, Du Y

Drug Design, Development and Therapy 2019, 13:3091-3103

Published Date: 28 August 2019

Antiproliferative activity and possible mechanism of action of certain 5-methoxyindole tethered C-5 functionalized isatins

Almutairi MS, Hassan ES, Keeton AB, Piazza GA, Abdelhameed AS, Attia MI

Drug Design, Development and Therapy 2019, 13:3069-3078

Published Date: 27 August 2019

Ketamine and depression: a narrative review

Corriger A, Pickering G

Drug Design, Development and Therapy 2019, 13:3051-3067

Published Date: 27 August 2019

Arsenic sulfide induces miR-4665-3p to inhibit gastric cancer cell invasion and migration

Zhang X, Tan Z, Kang T, Zhu C, Chen S

Drug Design, Development and Therapy 2019, 13:3037-3049

Published Date: 26 August 2019

Isolation, pharmacological evaluation and molecular docking studies of bioactive compounds from Grewia optiva

Ul Bari W, Zahoor M, Zeb A, Sahibzada MUK, Ullah R, Shahat AA, Mahmood HM, Khan I

Drug Design, Development and Therapy 2019, 13:3029-3036

Published Date: 26 August 2019

Synthesis and antitumor evaluation of neolaxiflorin B inspired compounds

Liu JP, Xiao YZ, Hu Y, Li XN, Wu MJ, Zhao Y, Zhao Y, Ma ZJ, Shen J

Drug Design, Development and Therapy 2019, 13:3021-3028

Published Date: 23 August 2019

Network pharmacology study on the active components of Pterocypsela elata and the mechanism of their effect against cerebral ischemia

Niu B, Zhang H, Li C, Yan F, Song Y, Hai G, Jiao Y, Feng Y

Drug Design, Development and Therapy 2019, 13:3009-3019

Published Date: 5 September 2019

The development of an oral GLP-1 receptor agonist for the management of type 2 diabetes: evidence to date

Antza C, Nirantharakumar K, Doundoulakis I, Tahrani AA, Toulis KA

Drug Design, Development and Therapy 2019, 13:2985-2996

Published Date: 22 August 2019

Attractor – a new turning point in drug discovery

Hou X, Li M, Jia C, Zhang X, Wang Y

Drug Design, Development and Therapy 2019, 13:2957-2968

Published Date: 22 August 2019

Total extract of Xin Jia Xuan Bai Cheng Qi decoction inhibits pulmonary fibrosis via the TGF-β/Smad signaling pathways in vivo and in vitro

Qin H, Wen HT, Gu KJ, Hu XD, Yang T, Yan XF, Ye TJ, Huo JL, Hu J

Drug Design, Development and Therapy 2019, 13:2873-2886

Published Date: 19 August 2019

Validated UPLC-MS/MS method for quantification of fruquintinib in rat plasma and its application to pharmacokinetic study

Mei YB, Luo SB, Ye LY, Zhang Q, Guo J, Qiu XJ, Xie SL

Drug Design, Development and Therapy 2019, 13:2865-2871

Published Date: 15 August 2019

Overexpression of SOX9 alleviates the progression of human osteoarthritis in vitro and in vivo

Ouyang Y, Wang W, Tu B, Zhu Y, Fan C, Li Y

Drug Design, Development and Therapy 2019, 13:2833-2842

Published Date: 13 August 2019

Protective effects of tiopronin against oxidative stress in severely burned patients

Qin FJ, Hu XH, Chen Z, Chen X, Shen YM

Drug Design, Development and Therapy 2019, 13:2827-2832

Published Date: 13 August 2019

eIF2α promotes vascular remodeling via autophagy in monocrotaline-induced pulmonary arterial hypertension rats

Guo L, Li Y, Tian Y, Gong S, Chen X, Peng T, Wang A, Jiang Z

Drug Design, Development and Therapy 2019, 13:2799-2809

Published Date: 13 August 2019

Minoxidil and its use in hair disorders: a review

Suchonwanit P, Thammarucha S, Leerunyakul K

Drug Design, Development and Therapy 2019, 13:2777-2786

Published Date: 9 August 2019

Effects of acarbose and metformin on the inflammatory state in newly diagnosed type 2 diabetes patients: a one-year randomized clinical study

Mo D, Liu S, Ma H, Tian H, Yu H, Zhang X, Tong N, Liao J, Ren Y

Drug Design, Development and Therapy 2019, 13:2769-2776

Published Date: 9 August 2019

Cerebral protection of epigallocatechin gallate (EGCG) via preservation of mitochondrial function and ERK inhibition in a rat resuscitation model

Qin S, Chen MH, Fang W, Tan XF, Xie L, Yang YG, Qin T, Li N

Drug Design, Development and Therapy 2019, 13:2759-2768

Published Date: 7 August 2019

Liraglutide attenuates cardiac remodeling and improves heart function after abdominal aortic constriction through blocking angiotensin II type 1 receptor in rats

Zheng RH, Bai XJ, Zhang WW, Wang J, Bai F, Yan CP, James EA, Bose HS, Wang NP, Zhao Z

Drug Design, Development and Therapy 2019, 13:2745-2757

Published Date: 6 August 2019

Neuroprotective effects of melatonin and celecoxib against ethanol-induced neurodegeneration: a computational and pharmacological approach

Al Kury LT, Zeb A, Abidin ZU, Irshad N, Malik I, Alvi AM, Khalil AAK, Ahmad S, Faheem M, Khan AU, Shah FA, Li S

Drug Design, Development and Therapy 2019, 13:2715-2727

Published Date: 2 August 2019

Orcinol glucoside facilitates the shift of MSC fate to osteoblast and prevents adipogenesis via Wnt/β-catenin signaling pathway

Zhou X, Liu Z, Huang B, Yan H, Yang C, Li Q, Jin D

Drug Design, Development and Therapy 2019, 13:2703-2713

Published Date: 5 August 2019

Systemic taurine treatment provides neuroprotection against retinal photoreceptor degeneration and visual function impairments

Tao Y, He M, Yang Q, Ma Z, Qu Y, Chen W, Peng G, Teng D

Drug Design, Development and Therapy 2019, 13:2689-2702

Published Date: 7 August 2019

Dextromethorphan and memantine after ketamine analgesia: a randomized control trial

Martin E, Sorel M, Morel V, Marcaillou F, Picard P, Delage N, Tiberghien F, Crosmary MC, Najjar M, Colamarino R, Créach C, Lietar B, Brumauld de Montgazon G, Margot-Duclot A, Loriot MA, Narjoz C, Lambert C, Pereira B, Pickering G

Drug Design, Development and Therapy 2019, 13:2677-2688

Published Date: 2 August 2019

Carvedilol attenuates carbon tetrachloride-induced liver fibrosis and hepatic sinusoidal capillarization in mice

Wu Y, Li Z, Xiu AY, Meng DX, Wang SN, Zhang CQ

Drug Design, Development and Therapy 2019, 13:2667-2676

Published Date: 1 August 2019

An investigation of the stability of meropenem in elastomeric infusion devices

Foy F, Luna G, Martinez J, Nizich Z, Seet J, Lie K, Sunderland B, Czarniak P

Drug Design, Development and Therapy 2019, 13:2655-2665

Published Date: 1 August 2019

Efficacy of chloral hydrate oral solution for sedation in pediatrics: a systematic review and meta-analysis

Chen Z, Lin M, Huang Z, Zeng L, Huang L, Yu D, Zhang L

Drug Design, Development and Therapy 2019, 13:2643-2653

Published Date: 31 July 2019

Effects of ondansetron and [6]-gingerol on pica and gut microbiota in rats treated with cisplatin

Feng X, Cheng Q, Meng Q, Yang Y, Nie K

Drug Design, Development and Therapy 2019, 13:2633-2641

Published Date: 1 August 2019

Role of heat shock protein 22 in the protective effect of geranylgeranylacetone in response to oxidized-LDL

Gong R, Li XY, Chen HJ, Xu CC, Fang HY, Xiang J, Wu YQ

Drug Design, Development and Therapy 2019, 13:2619-2632

Published Date: 30 July 2019

Effects of losartan and atorvastatin on the development of early posttraumatic joint stiffness in a rat model

Baranowski A, Schlemmer L, Förster K, Slotina E, Mickan T, Truffel S, Klein A, Mattyasovszky SG, Hofmann A, Ritz U, Rommens PM

Drug Design, Development and Therapy 2019, 13:2603-2618

Published Date: 30 July 2019

Astragaloside IV protects endothelial progenitor cells from the damage of ox-LDL via the LOX-1/NLRP3 inflammasome pathway

Qian W, Cai X, Qian Q, Zhuang Q, Yang W, Zhang X, Zhao L

Drug Design, Development and Therapy 2019, 13:2579-2589

Published Date: 29 July 2019

Erythropoietin enhances osteogenic differentiation of human periodontal ligament stem cells via Wnt/β-catenin signaling pathway

Zheng DH, Wang XX, Ma D, Zhang LN, Qiao QF, Zhang J

Drug Design, Development and Therapy 2019, 13:2543-2552

Published Date: 26 July 2019

Downregulation of microRNA-23b-3p alleviates IL-1β-induced injury in chondrogenic CHON-001 cells

Yang Q, Zhou Y, Cai P, Fu W, Wang J, Wei Q, Li X

Drug Design, Development and Therapy 2019, 13:2503-2512

Published Date: 23 July 2019

Physicochemical properties and drug-release mechanisms of dual-release bilayer tablet containing mirabegron and fesoterodine fumarate

Lee HG, Park YS, Jeong JH, Kwon YB, Shin DH, Kim JY, Rhee YS, Park ES, Kim DW, Park CW

Drug Design, Development and Therapy 2019, 13:2459-2474

Published Date: 23 July 2019

Synthesis and antihepatotoxic activity of dihydropyrimidinone derivatives linked with 1,4-benzodioxane

Bhat MA, Al-Omar MA, Khan AA, Alanazi AM, Naglah AM

Drug Design, Development and Therapy 2019, 13:2393-2404

Published Date: 18 July 2019

A new approach of ocular nebulization with vitamin B12 versus oxytocin for the treatment of dry eye disease: an in vivo confocal microscopy study

Yang J, Liu Y, Xu Y, Li X, Fu J, Jiang X, Chou Y, Ma J, Hao R, Zhang R, Qiu W, Li X

Drug Design, Development and Therapy 2019, 13:2381-2391

Published Date: 18 July 2019

MicroRNA-664 suppresses the growth of cervical cancer cells via targeting c-Kit

Lv M, Ou R, Zhang Q, Lin F, Li X, Wang K, Xu Y

Drug Design, Development and Therapy 2019, 13:2371-2379

Published Date: 17 July 2019

Plumbagin promotes human hepatoma SMMC-7721 cell apoptosis via caspase-3/vimentin signal-mediated EMT

Wei Y, Lv B, Xie J, Zhang Y, Lin Y, Wang S, Zhong J, Chen Y, Peng Y, Ma J

Drug Design, Development and Therapy 2019, 13:2343-2355

Published Date: 15 July 2019

Lycopene protects against myocardial ischemia-reperfusion injury by inhibiting mitochondrial permeability transition pore opening

Li X, Jia P, Huang Z, Liu S, Miao J, Guo Y, Wu N, Jia D

Drug Design, Development and Therapy 2019, 13:2331-2342

Published Date: 11 July 2019

Differences in tolerability of pirfenidone between elderly and younger patients with idiopathic pulmonary fibrosis

Sakayori M, Terada J, Abe M, Hirasawa Y, Suzuki K, Yoshioka K, Tsushima K, Tatsumi K

Drug Design, Development and Therapy 2019, 13:2295-2303

Published Date: 11 July 2019

Durability of INI-containing regimens after switching from PI-containing regimens: a single-centre cohort of drug-experienced HIV-infected subjects

Giacomelli A, Ranzani A, Oreni L, Gervasi E, Lupo A, Ridolfo AL, Galli M, Rusconi S

Drug Design, Development and Therapy 2019, 13:2271-2282

Published Date: 9 July 2019

The protective effect and mechanism of the FXR agonist obeticholic acid via targeting gut microbiota in non-alcoholic fatty liver disease

Zhang DY, Zhu L, Liu HN, Tseng YJ, Weng SQ, Liu TT, Dong L, Shen XZ

Drug Design, Development and Therapy 2019, 13:2249-2270

Published Date: 5 July 2019

Jatrorrhizine inhibits colorectal carcinoma proliferation and metastasis through Wnt/β-catenin signaling pathway and epithelial–mesenchymal transition

Wang P, Gao XY, Yang SQ, Sun ZX, Dian LL, Qasim M, Phyo AT, Liang ZS, Sun YF

Drug Design, Development and Therapy 2019, 13:2235-2247

Published Date: 8 July 2019

Delivery of folic acid-modified liposomal curcumin for targeted cervical carcinoma therapy

Wang WY, Cao YX, Zhou X, Wei B

Drug Design, Development and Therapy 2019, 13:2205-2213

Published Date: 4 July 2019

Activation of the P38/CREB/MMP13 axis is associated with osteoarthritis

Ji B, Ma Y, Wang H, Fang X, Shi P

Drug Design, Development and Therapy 2019, 13:2195-2204

Published Date: 3 July 2019

Tablet or capsule form of generic mycophenolate mofetil (My-Rept®) after liver transplantation: a prospective randomized trial

Kim JM, Oh JW, Kim S, Rhu J, Lee JS, Kim KS, Choi GS, Joh JW

Drug Design, Development and Therapy 2019, 13:2187-2193

Published Date: 2 July 2019

Evaluation of novel pyrimidine derivatives as a new class of mushroom tyrosinase inhibitor

Mirmortazavi SS, Farvandi M, Ghafouri H, Mohammadi A, Shourian M

Drug Design, Development and Therapy 2019, 13:2169-2178

Published Date: 8 July 2019

Preemptive analgesia after lumbar spine surgery by pregabalin and celecoxib: a prospective study

Kien NT, Geiger P, Van Chuong H, Cuong NM, Van Dinh N, Pho DC, Anh VT, Giang NT

Drug Design, Development and Therapy 2019, 13:2145-2152

Published Date: 3 July 2019

Role of GRP78 inhibiting artesunate-induced ferroptosis in KRAS mutant pancreatic cancer cells

Wang K, Zhang Z, Wang M, Cao X, Qi J, Wang D, Gong A, Zhu H

Drug Design, Development and Therapy 2019, 13:2135-2144

Published Date: 2 July 2019

Ginsenoside Rb1 pretreatment reverses hippocampal changes in BDNF/TrkB mRNA and protein in rats subjected to acute immobilization stress

Kang X, Hong W, Xie K, Tang H, Tang J, Luo S, Geng W, Jia D

Drug Design, Development and Therapy 2019, 13:2127-2134

Published Date: 1 July 2019

Phosphocreatine attenuates Gynura segetum-induced hepatocyte apoptosis via a SIRT3-SOD2-mitochondrial reactive oxygen species pathway

Li DP, Chen YL, Jiang HY, Chen Y, Zeng XQ, Xu LL, Ye Y, Ke CQ, Lin G, Wang JY, Gao H

Drug Design, Development and Therapy 2019, 13:2081-2096

Published Date: 27 June 2019

Dexmedetomidine protects PC12 cells from lidocaine-induced cytotoxicity via downregulation of Stathmin 1

Tan Y, Bi X, Wang Q, Li Y, Zhang N, Lao J, Liu X

Drug Design, Development and Therapy 2019, 13:2067-2079

Published Date: 3 July 2019

Ginsenoside Rg3 protects mouse leydig cells against triptolide by downregulation of miR-26a

Liang H, Zhang S, Li Z

Drug Design, Development and Therapy 2019, 13:2057-2066

Published Date: 24 June 2019

A novel mutation panel for predicting etoposide resistance in small-cell lung cancer

Qiu Z, Lin A, Li K, Lin W, Wang Q, Wei T, Zhu W, Luo P, Zhang J

Drug Design, Development and Therapy 2019, 13:2021-2041

Published Date: 21 June 2019

TMF inhibits miR-29a/Wnt/β-catenin signaling through upregulating Foxo3a activity in osteoarthritis chondrocytes

Huang X, Chen Z, Shi W, Zhang R, Li L, Liu H, Wu L

Drug Design, Development and Therapy 2019, 13:2009-2019

Published Date: 19 June 2019

Evaluating guselkumab: an anti-IL-23 antibody for the treatment of plaque psoriasis

Yang EJ, Smith MP, Ly K, Bhutani T

Drug Design, Development and Therapy 2019, 13:1993-2000

Published Date: 18 June 2019

Efficacy and safety of total glucosides of paeony combined with methotrexate and leflunomide for active rheumatoid arthritis: a meta-analysis

Huang Y, Wang H, Chen Z, Wang Y, Qin K, Huang Y, Ba X, Lin W, Tu S

Drug Design, Development and Therapy 2019, 13:1969-1984

Published Date: 17 June 2019

The neuroprotective effect of bisperoxovandium (pyridin-2-squaramide) in intracerebral hemorrhage

Liao XY, Lei Y, Chen SF, Cheng J, Zhao D, Zhang ZF, Han X, Zhang Y, Liao HB, Zhuang Y, Chen J, Zhou HB, Wan Q, Zou YY

Drug Design, Development and Therapy 2019, 13:1957-1967

Published Date: 13 June 2019

Solutol®HS15+pluronicF127 and Solutol®HS15+pluronicL61 mixed micelle systems for oral delivery of genistein

Ding P, Chen Y, Cao G, Shen H, Ju J, Li W

Drug Design, Development and Therapy 2019, 13:1947-1956

Published Date: 7 June 2019

Notopterol-induced apoptosis and differentiation in human acute myeloid leukemia HL-60 cells

Huang Q, Wang L, Ran Q, Wang J, Wang C, He H, Li L, Qi H

Drug Design, Development and Therapy 2019, 13:1927-1940

Published Date: 6 June 2019

Decreased sEng plasma levels in hypertensive patients with endothelial dysfunction under chronic treatment with Perindopril

Buda V, Andor M, Baibata DE, Cozlac R, Radu G, Coricovac D, Danciu C, Ledeti I, Cheveresan A, Nica C, Tuduce P, Tomescu MC

Drug Design, Development and Therapy 2019, 13:1915-1925

Published Date: 4 June 2019

Effects of Qi Teng Xiao Zhuo granules on circRNA expression profiles in rats with chronic glomerulonephritis

Gao JR, Jiang NN, Jiang H, Wei LB, Gao YC, Qin XJ, Zhu MQ, Wang J

Drug Design, Development and Therapy 2019, 13:1901-1913

Published Date: 4 June 2019

Efficacy and toxicity of cladribine for the treatment of refractory acute myeloid leukemia: a meta-analysis

Zhou A, Han Q, Song H, Zi J, Ma J, Ge Z

Drug Design, Development and Therapy 2019, 13:1867-1878

Published Date: 29 May 2019

Therapeutic potential of pravastatin for random skin flaps necrosis: involvement of promoting angiogenesis and inhibiting apoptosis and oxidative stress [Corrigendum]

Lin J, Jia C, Wang Y, Jiang S, Jia Z, Chen N, Sheng S, Li S, Jiang L, Xu H, Zhou K, Chen Y

Drug Design, Development and Therapy 2019, 13:1865-1866

Published Date: 29 May 2019

Use of lidocaine to prevent postoperative coughing after partial laryngectomy: comparison of three delivery methods

Wang Y, Lu WS, Qiao H, Zhao J, Fan Q

Drug Design, Development and Therapy 2019, 13:1835-1841

Published Date: 27 May 2019

A novel non-invasive monitoring assay of 5-azacitidine efficacy using global DNA methylation of peripheral blood in myelodysplastic syndrome

Asano M, Ohyashiki JH, Kobayashi-Kawana C, Umezu T, Imanishi S, Azuma K, Akahane D, Fujimoto H, Ito Y, Ohyashiki K

Drug Design, Development and Therapy 2019, 13:1821-1833

Published Date: 30 May 2019

Ferulic acid attenuates liver fibrosis and hepatic stellate cell activation via inhibition of TGF-β/Smad signaling pathway [Corrigendum]

Mu M, Zuo S, Wu RM, Deng KS, Lu S, Zhu JJ, Zou GL, Yang J, Cheng ML, Zhao XK

Drug Design, Development and Therapy 2019, 13:1819-1820

Published Date: 24 May 2019

Frequency, clinical features and differential response to therapy of concurrent ALK/EGFR alterations in Chinese lung cancer patients

Liu J, Mu Z, Liu L, Li K, Jiang R, Chen P, Zhou Q, Jin M, Ma Y, Xie Y, Xiang J, Li B, Ma Y, Mao X, Zhang L, Zhang T, Wu D

Drug Design, Development and Therapy 2019, 13:1809-1817

Published Date: 23 May 2019

Effect of dexmedetomidine on etomidate-induced myoclonus: a randomized, double-blind controlled trial

Miao S, Zou L, Wang G, Wang X, Liu S, Shi M

Drug Design, Development and Therapy 2019, 13:1803-1808

Published Date: 27 May 2019

Low-dose doxycycline inhibits hydrogen peroxide-induced oxidative stress, MMP-2 up-regulation and contractile dysfunction in human saphenous vein grafts

Saeed M, Arun MZ, Guzeloglu M, Onursal C, Gokce G, Korkmaz CG, Reel B

Drug Design, Development and Therapy 2019, 13:1791-1801

Published Date: 23 May 2019

Synthesis, comparative docking, and pharmacological activity of naproxen amino acid derivatives as possible anti-inflammatory and analgesic agents

Elhenawy AA, Al-Harbi LM, Moustafa GO, El-Gazzar MA, Abdel-Rahman RF, Salim AE

Drug Design, Development and Therapy 2019, 13:1773-1790

Published Date: 24 May 2019

SU5416 attenuated lipopolysaccharide-induced acute lung injury in mice by modulating properties of vascular endothelial cells

Huang X, Zhu J, Jiang Y, Xu C, Lv Q, Yu D, Shi K, Ruan Z, Wang Y

Drug Design, Development and Therapy 2019, 13:1763-1772

Published Date: 23 May 2019

Population pharmacokinetic analysis of tramadol and O-desmethyltramadol with genetic polymorphism of CYP2D6

Lee J, Yoo H, Bae JW, Lee S, Shin K

Drug Design, Development and Therapy 2019, 13:1751-1761

Published Date: 23 May 2019

The effect of midazolam administration for the prevention of emergence agitation in pediatric patients with extreme fear and non-cooperation undergoing dental treatment under sevoflurane anesthesia, a double-blind, randomized study

Kawai M, Kurata S, Sanuki T, Mishima G, Kiriishi K, Watanabe T, Ozaki-Honda Y, Yoshida M, Okayasu I, Ayuse T, Tanoue N, Ayuse T

Drug Design, Development and Therapy 2019, 13:1729-1737

Published Date: 17 May 2019

Genetic variations in the transcription factors GATA4 and GATA6 and bleeding complications in patients receiving warfarin therapy

Yee J, Kim W, Chang BC, Chung JE, Lee KE, Gwak HS

Drug Design, Development and Therapy 2019, 13:1717-1727

Published Date: 17 May 2019

Sevoflurane post-conditioning alleviates neonatal rat hypoxic-ischemic cerebral injury via Ezh2-regulated autophagy

Xue H, Xu Y, Wang S, Wu ZY, Li XY, Zhang YH, Niu JY, Gao QS, Zhao P

Drug Design, Development and Therapy 2019, 13:1691-1706

Published Date: 15 May 2019

Efficacy of a recombinant single-chain fragment variable region, VasSF, as a new drug for vasculitis [Corrigendum]

Kameoka Y, Kishi F, Koura M, Yamakawa Y, Nagasawa R, Ito F, Matsuda J, Suzuki O, Nakayama T, Suzuki K

Drug Design, Development and Therapy 2019, 13:1689-1690

Published Date: 22 May 2019

Cardiovascular adverse events during treatment with darunavir-based regimens in an Italian observational study

Antinori A, Rusconi S, Gianotti N, Bini T, Mancusi D, Termini R

Drug Design, Development and Therapy 2019, 13:1667-1685

Published Date: 14 May 2019

Dexibuprofen amide derivatives as potential anticancer agents: synthesis, in silico docking, bioevaluation, and molecular dynamic simulation

Ashraf Z, Mahmood T, Hassan M, Afzal S, Rafique H, Afzal K, Latip J

Drug Design, Development and Therapy 2019, 13:1643-1657

Published Date: 14 May 2019

Pharmacokinetics of fixed-dose combination of atorvastatin and metformin compared with individual tablets

Ghim JL, Phuong NTT, Kim MJ, Kim EJ, Song GS, Ahn S, Shin JG, Kim EY

Drug Design, Development and Therapy 2019, 13:1623-1632

Published Date: 13 May 2019

Formulation and evaluation of simvastatin polymeric nanoparticles loaded in hydrogel for optimum wound healing purpose

Farghaly Aly U, Abou-Taleb HA, Abdellatif AH, Sameh Tolba N

Drug Design, Development and Therapy 2019, 13:1567-1580

Published Date: 10 May 2019

In silico and in vitro studies of lupeol and iso-orientin as potential antidiabetic agents in a rat model

Malik A, Jamil U, Butt TT, Waquar S, Gan SH, Shafique H, Jafar TH

Drug Design, Development and Therapy 2019, 13:1501-1513

Published Date: 6 May 2019

Resveratrol reduces liver endoplasmic reticulum stress and improves insulin sensitivity in vivo and in vitro

Zhao H, Zhang Y, Shu L, Song G, Ma H

Drug Design, Development and Therapy 2019, 13:1473-1485

Published Date: 2 May 2019

Therapeutic potential of pravastatin for random skin flaps necrosis: involvement of promoting angiogenesis and inhibiting apoptosis and oxidative stress

Lin J, Jia C, Wang Y, Jiang S, Jia Z, Chen N, Sheng S, Li S, Jiang L, Xu H, Zhou K, Chen Y

Drug Design, Development and Therapy 2019, 13:1461-1472

Published Date: 1 May 2019

Synthesis of a vanadyl (IV) folate complex for the treatment of diabetes: spectroscopic, structural, and biological characterization

Naglah AM, Refat MS, Al-Omar MA, Bhat MA, AlKahtani HM, Al-Wasidi AS

Drug Design, Development and Therapy 2019, 13:1409-1420

Published Date: 30 April 2019

The TwistDock workflow for evaluation of bivalent Smac mimetics targeting XIAP

Huang Q, Peng Y, Peng Y, Wei D, Wei Y, Feng S

Drug Design, Development and Therapy 2019, 13:1373-1388

Published Date: 26 April 2019

Codelivery of GRP78 siRNA and docetaxel via RGD-PEG-DSPE/DOPA/CaP nanoparticles for the treatment of castration-resistant prostate cancer

Zhang X, He Z, Xiang L, Li L, Zhang H, Lin F, Cao H

Drug Design, Development and Therapy 2019, 13:1357-1372

Published Date: 29 April 2019

Clinical efficacy of 60-mg dexlansoprazole and 40-mg esomeprazole after 24 weeks for the on-demand treatment of gastroesophageal reflux disease grades A and B: a prospective randomized trial

Chiang HH, Wu DC, Hsu PI, Kuo CH, Tai WC, Yang SC, Wu KL, Yao CC, Tsai CE, Liang CM, Wang YK, Wang JW, Huang CF, Chuah SK

Drug Design, Development and Therapy 2019, 13:1347-1356

Published Date: 26 April 2019

Caffeic acid phenethyl ester suppressed growth and metastasis of nasopharyngeal carcinoma cells by inactivating the NF-κB pathway

Liang Y, Feng G, Wu L, Zhong S, Gao X, Tong Y, Cui W, Qin Y, Xu WQ, Xiao X, Zhang Z, Huang G, Zhou X

Drug Design, Development and Therapy 2019, 13:1335-1345

Published Date: 26 April 2019

Epigallocatechin-3-gallate enhances the osteoblastogenic differentiation of human adipose-derived stem cells

Zhang J, Wu K, Xu T, Wu J, Li P, Wang H, Wu H, Wu G

Drug Design, Development and Therapy 2019, 13:1311-1321

Published Date: 23 April 2019

Effects of dezocine for the prevention of postoperative catheter-related bladder discomfort: a prospective randomized trial

Zhang GF, Guo J, Qiu LL, Li SM, Zheng M, Xia JY, Yang JJ

Drug Design, Development and Therapy 2019, 13:1281-1288

Published Date: 23 April 2019

Pharmacokinetics and pharmacodynamics of the novel Nrf2 activator omaveloxolone in primates

Reisman SA, Gahir SS, Lee CY, Proksch JW, Sakamoto M, Ward KW

Drug Design, Development and Therapy 2019, 13:1259-1270

Published Date: 17 April 2019

The molecular mechanisms of Aloin induce gastric cancer cells apoptosis by targeting High Mobility Group Box 1

Tao H, Tang T, Wang S, Wang Z, Ma Y, Cai T, Cheng X, Qi S, Zhang Y, Qi Z

Drug Design, Development and Therapy 2019, 13:1221-1231

Published Date: 17 April 2019

Effect of butorphanol on etomidate-induced myoclonus: a systematic review and meta-analysis

Hua J, Miao S, Shi M, Tu Q, Wang X, Liu S, Wang G, Gan J

Drug Design, Development and Therapy 2019, 13:1213-1220

Published Date: 16 April 2019

Beneficial effects of resveratrol and exercise training on cardiac and aortic function and structure in the 3xTg mouse model of Alzheimer’s disease

Esfandiarei M, Hoxha B, Talley NA, Anderson MR, Alkhouli MF, Squire MA, Eckman DM, Babu JR, Lopaschuk GD, Broderick TL

Drug Design, Development and Therapy 2019, 13:1197-1211

Published Date: 17 April 2019

Tetramethylpyrazine attenuated bupivacaine-induced neurotoxicity in SH-SY5Y cells through regulating apoptosis, autophagy and oxidative damage

Wang S, Xia B, Qiao Z, Duan L, Wang G, Meng W, Liu Z, Wang Y, Zhang M

Drug Design, Development and Therapy 2019, 13:1187-1196

Published Date: 17 April 2019

Effect of umbelliferone on adjuvant-induced arthritis in rats by MAPK/NF-κB pathway

Ouyang L, Dan Y, Shao Z, Yang S, Yang C, Liu G, Zhou W, Duan D

Drug Design, Development and Therapy 2019, 13:1163-1170

Published Date: 11 April 2019

Quizartinib (AC220): a promising option for acute myeloid leukemia

Zhou F, Ge Z, Chen B

Drug Design, Development and Therapy 2019, 13:1117-1125

Published Date: 8 April 2019

A novel hybrid compound LLP2A-alendronate accelerates open fracture healing in a rabbit model

Wang Z, Zhao Y, Zhang D, Qi B, Xiao W, Hu X, Yu A

Drug Design, Development and Therapy 2019, 13:1077-1086

Published Date: 5 April 2019

Systematic elucidation of the mechanism of geraniol via network pharmacology

Zhang YF, Huang Y, Ni YH, Xu ZM

Drug Design, Development and Therapy 2019, 13:1069-1075

Published Date: 4 April 2019

Transportan-derived cell-penetrating peptide delivers siRNA to inhibit replication of influenza virus in vivo

Zhang C, Ren W, Liu Q, Tan Z, Li J, Tong C

Drug Design, Development and Therapy 2019, 13:1059-1068

Published Date: 4 April 2019

Formulation and bioequivalence studies of choline alfoscerate tablet comparing with soft gelatin capsule in healthy male volunteers

Min MH, Park JH, Hur JH, Shin HC, Cho YJ, Kim DD

Drug Design, Development and Therapy 2019, 13:1049-1058

Published Date: 5 April 2019

Metabolism of remimazolam in primary human hepatocytes during continuous long-term infusion in a 3-D bioreactor system

Freyer N, Knöspel F, Damm G, Greuel S, Schneider C, Seehofer D, Stöhr T, Petersen KU, Zeilinger K

Drug Design, Development and Therapy 2019, 13:1033-1047

Published Date: 2 April 2019

Jinlong capsule inhibits migration and invasion in human glioblastoma cells via the modulation of mTOR/S6 signaling pathway

Shi J, Zhang W, He L, Kong F, Pan M, Guo J, Xu X, Guo J, Wang H, Wang Y

Drug Design, Development and Therapy 2019, 13:1023-1032

Published Date: 1 April 2019

Efficacy and safety of paricalcitol in patients undergoing hemodialysis: a meta-analysis

Liu Y, Liu LY, Jia Y, Wu MY, Sun YY, Ma FZ

Drug Design, Development and Therapy 2019, 13:999-1009

Published Date: 28 March 2019

Emodin alleviates myocardial ischemia/reperfusion injury by inhibiting gasdermin D-mediated pyroptosis in cardiomyocytes

Ye B, Chen X, Dai S, Han J, Liang X, Lin S, Cai X, Huang Z, Huang W

Drug Design, Development and Therapy 2019, 13:975-990

Published Date: 25 March 2019

Mechanistic research holds promise for bacterial vaccines and phage therapies for Pseudomonas aeruginosa

Hoggarth A, Weaver A, Pu Q, Huang T, Schettler J, Chen F, Yuan X, Wu M

Drug Design, Development and Therapy 2019, 13:909-924

Published Date: 20 March 2019

Protective role of quercetin against manganese-induced injury in the liver, kidney, and lung; and hematological parameters in acute and subchronic rat models [Retraction]

Bahar E, Lee GH, Bhattarai KR, Lee HY, Kim HK, Handigund M, Choi MK, Han SY, Chae HJ, Yoon H

Drug Design, Development and Therapy 2019, 13:907-908

Published Date: 18 March 2019

Drug-release system of microchannel transport used in minimally invasive surgery for hemostasis

Huang H, Liu H, Zhou H, Liang Z, Song D, Zhang Y, Huang W, Zhao X, Wu B, Ye G, Huang Y

Drug Design, Development and Therapy 2019, 13:881-896

Published Date: 12 March 2019

Efficacy and safety of tacrolimus in induction therapy of patients with lupus nephritis

Zhou TB, Lin SJ, Yang S, Lin WS

Drug Design, Development and Therapy 2019, 13:857-869

Published Date: 12 March 2019

Clinical efficacy and safety of rituximab in lupus nephritis

Zhong Z, Li H, Zhong H, Zhou T

Drug Design, Development and Therapy 2019, 13:845-856

Published Date: 11 March 2019

Single-use suvorexant for treating insomnia during overnight polysomnography in patients with suspected obstructive sleep apnea: a single-center experience

Matsumura T, Terada J, Yoshimura C, Koshikawa K, Kinoshita T, Yahaba M, Nagashima K, Sakao S, Tatsumi K

Drug Design, Development and Therapy 2019, 13:809-816

Published Date: 28 February 2019

Utility of nintedanib for severe idiopathic pulmonary fibrosis: a single-center retrospective study [Corrigendum]

Abe M, Tsushima K, Sakayori M, Suzuki K, Ikari J, Terada J, Tatsumi K

Drug Design, Development and Therapy 2019, 13:807-808

Published Date: 28 February 2019

Physicochemical characterization and phase I study of CMAB008, an infliximab biosimilar produced by a different expression system

An Q, Zheng Y, Zhao Y, Liu T, Guo H, Zhang D, Qian W, Wang H, Guo Y, Hou S, Li J

Drug Design, Development and Therapy 2019, 13:791-805

Published Date: 12 March 2019

Synthesis, structure elucidation, and antifungal potential of certain new benzodioxole–imidazole molecular hybrids bearing ester functionalities

Al-Wabli RI, Al-Ghamdi AR, Ghabbour HA, Al-Agamy MH, Attia MI

Drug Design, Development and Therapy 2019, 13:775-789

Published Date: 26 February 2019

Ginkgolide B ameliorates myocardial ischemia reperfusion injury in rats via inhibiting endoplasmic reticulum stress

Guo C, Zhang J, Zhang P, Si A, Zhang Z, Zhao L, Lv F, Zhao G

Drug Design, Development and Therapy 2019, 13:767-774

Published Date: 26 February 2019

Monosialoganglioside protects against bupivacaine-induced neurotoxicity caused by endoplasmic reticulum stress in rats

Liu B, Ji J, Feng Q, Luo X, Yan X, Ni Y, He Y, Mao Z, Liu J

Drug Design, Development and Therapy 2019, 13:707-718

Published Date: 19 February 2019

Dexmedetomidine attenuates the neurotoxicity of propofol toward primary hippocampal neurons in vitro via Erk1/2/CREB/BDNF signaling pathways

Tu Y, Liang Y, Xiao Y, Lv J, Guan R, Xiao F, Xie Y, Xiao Q

Drug Design, Development and Therapy 2019, 13:695-706

Published Date: 19 February 2019

Synthesis of budesonide conjugates and their anti-inflammatory effects: a preliminary study

Yan Y, Wang P, Li R, Sun Y, Zhang R, Huo C, Xing J, Dong Y

Drug Design, Development and Therapy 2019, 13:681-694

Published Date: 19 February 2019

Update in treatment of uveitic macular edema

Koronis S, Stavrakas P, Balidis M, Kozeis N, Tranos PG

Drug Design, Development and Therapy 2019, 13:667-680

Published Date: 19 February 2019

Ginkgo biloba extract-761 protects myocardium by regulating Akt/Nrf2 signal pathway

Chen X, Ren S, Dong J, Qiu C, Chen Y, Tao H

Drug Design, Development and Therapy 2019, 13:647-655

Published Date: 13 February 2019

Epigallocatechin-3-gallate in the prevention and treatment of hepatocellular carcinoma: experimental findings and translational perspectives

Bimonte S, Albino V, Piccirillo M, Nasto A, Molino C, Palaia R, Cascella M

Drug Design, Development and Therapy 2019, 13:611-621

Published Date: 12 February 2019

Emodin induces apoptosis and autophagy of fibroblasts obtained from patient with ankylosing spondylitis

Ma C, Wen B, Zhang Q, Shao P, Gu W, Qu K, Shi Y, Wang B

Drug Design, Development and Therapy 2019, 13:601-609

Published Date: 11 February 2019

The underlying mechanisms of Jie-Du-Hua-Yu granule for protecting rat liver failure

Qiu H, Mao D, Tang N, Long F, Zhang R, Wang M, Shi Q, Li J, Jiang Q, Chen Y, Wang X

Drug Design, Development and Therapy 2019, 13:589-600

Published Date: 11 February 2019

Cathepsin G cleaves and activates IL-36γ and promotes the inflammation of psoriasis

Guo J, Tu J, Hu YY, Song GX, Yin ZQ

Drug Design, Development and Therapy 2019, 13:581-588

Published Date: 8 February 2019

Efficacy of a recombinant single-chain fragment variable region, VasSF, as a new drug for vasculitis

Kameoka Y, Kishi F, Koura M, Yamakawa Y, Nagasawa R, Ito F, Matsuda J, Suzuki O, Nakayama T, Suzuki K

Drug Design, Development and Therapy 2019, 13:555-568

Published Date: 5 February 2019

The benefit of taxane-based therapies over fluoropyrimidine plus platinum (FP) in the treatment of esophageal cancer: a meta-analysis of clinical studies

Wang T, Yu J, Liu M, Chen Y, Zhu C, Lu L, Wang M, Min L, Liu X, Zhang X, Gubat JA, Chen Y

Drug Design, Development and Therapy 2019, 13:539-553

Published Date: 5 February 2019

Safety and efficacy of atezolizumab in the treatment of cancers: a systematic review and pooled-analysis

Tie Y, Yang H, Zhao R, Zheng H, Yang D, Zhao J, Liu M

Drug Design, Development and Therapy 2019, 13:523-538

Published Date: 4 February 2019

Bisperoxovanadium protects against spinal cord injury by regulating autophagy via activation of ERK1/2 signaling

Tang Y, Li K, Yang C, Huang K, Zhou J, Shi Y, Xie K, Liu J

Drug Design, Development and Therapy 2019, 13:513-521

Published Date: 1 February 2019

A nucleoside-sparing regimen of dolutegravir plus ritonavir-boosted atazanavir in HIV-1-infected patients with virological failure: the DOLATAV study

Spagnuolo V, Galli L, Poli A, Bigoloni A, Fumagalli L, Gianotti N, Nozza S, Ferrari D, Locatelli M, Lazzarin A, Castagna A

Drug Design, Development and Therapy 2019, 13:477-479

Published Date: 24 January 2019

Qingxin kaiqiao fang ameliorates memory impairment and inhibits apoptosis in APP/PS1 double transgenic mice through the MAPK pathway

Gao SY, Lin J, Wang T, Shen Y, Li Y, Yang W, Zhou K, Hu H

Drug Design, Development and Therapy 2019, 13:459-475

Published Date: 23 January 2019

Structure–activity relationship of an antimicrobial peptide, Phylloseptin-PHa: balance of hydrophobicity and charge determines the selectivity of bioactivities

Liu Y, Du Q, Ma C, Xi X, Wang L, Zhou M, Burrows JF, Chen T, Wang H

Drug Design, Development and Therapy 2019, 13:447-458

Published Date: 23 January 2019

MicroRNA-339 inhibits human hepatocellular carcinoma proliferation and invasion via targeting ZNF689

Zeng H, Zheng J, Wen S, Luo J, Shao G, Zhang Y

Drug Design, Development and Therapy 2019, 13:435-445

Published Date: 22 January 2019

Design, synthesis, and biologic evaluation of novel chrysin derivatives as cytotoxic agents and caspase-3/7 activators

Al-Oudat BA, Alqudah MA, Audat SA, Al-Balas QA, El-Elimat T, Hassan MA, Frhat IN, Azaizeh MM

Drug Design, Development and Therapy 2019, 13:423-433

Published Date: 22 January 2019

A real-life experience of sorafenib treatment for patients with advanced hepatocellular carcinoma: a retrospective analysis at Cathay General Hospital, 2007–2015

Huang CC, Chen HY, Chang RH, Liao PA, Lien HH, Hung CS, Yang SS, Hu JT

Drug Design, Development and Therapy 2019, 13:397-404

Published Date: 22 January 2019

Screening of novel HSP-inducing compounds to conserve cardiomyocyte function in experimental atrial fibrillation

van Marion DMS, Hu X, Zhang D, Hoogstra-Berends F, Seerden JPG, Loen L, Heeres A, Steen H, Henning RH, Brundel BJJM

Drug Design, Development and Therapy 2019, 13:345-364

Published Date: 18 January 2019

YB-1 modulates the drug resistance of glioma cells by activation of MDM2/p53 pathway

Tong H, Zhao K, Zhang J, Zhu J, Xiao J

Drug Design, Development and Therapy 2019, 13:317-326

Published Date: 14 January 2019

A brief report of toxicity end points of HER2 vaccines for the treatment of patients with HER2+ breast cancer

Costa R, Zaman S, Sharpe S, Helenowski I, Shaw C, Han H, Soliman H, Czerniecki B

Drug Design, Development and Therapy 2019, 13:309-316

Published Date: 14 January 2019

Antistaphylococcal evaluation of indole–naphthalene hybrid analogs

Ashraf K, Yasrebi K, Adeniyi ET, Hertlein T, Ohlsen K, Lalk M, Erdmann F, Hilgeroth A

Drug Design, Development and Therapy 2019, 13:275-283

Published Date: 10 January 2019

Catalpol prevents denervated muscular atrophy related to the inhibition of autophagy and reduces BAX/BCL2 ratio via mTOR pathway

Wang Y, Shao YL, Gao YQ, Wan GR, Wan D, Zhu HF, Qiu Y, Ye XY

Drug Design, Development and Therapy 2019, 13:243-253

Published Date: 31 December 2018

A colon-specific prodrug of metoclopramide ameliorates colitis in an experimental rat model

Yang Y, Kim W, Kim D, Jeong S, Yoo JW, Jung Y

Drug Design, Development and Therapy 2019, 13:231-242

Published Date: 28 December 2018

Xyloketal derivative C53N protects against mild traumatic brain injury in mice

Liang F, Su F, Wang X, Long S, Zheng Y, He X, Pang J, Pei Z

Drug Design, Development and Therapy 2019, 13:173-182

Published Date: 27 December 2018

Urapidil, compared to nitroglycerin, has better clinical safety in the treatment of hypertensive patients with acute heart failure: a meta-analysis

Shi J, Li Y, Xing C, Peng P, Shi H, Ding H, Zheng P, Ning G, Feng S

Drug Design, Development and Therapy 2019, 13:161-172

Published Date: 27 December 2018

Fenofibrate modified-release pellets with lag phase and high oral bioavailability

Li F, Zheng X, Bao YC, Chen T, Zeng J, Xu XL, Yan C, Feng LL

Drug Design, Development and Therapy 2019, 13:141-151

Published Date: 24 December 2018

Tetrandrine suppresses cervical cancer growth by inducing apoptosis in vitro and in vivo

Zhang H, Xie B, Zhang Z, Sheng X, Zhang S

Drug Design, Development and Therapy 2019, 13:119-127

Published Date: 20 December 2018

Tocilizumab in the treatment of rheumatoid arthritis: an evidence-based review and patient selection

Biggioggero M, Crotti C, Becciolini A, Favalli EG

Drug Design, Development and Therapy 2019, 13:57-70

Published Date: 19 December 2018

Ocular side effects of levitra® (vardenafil) – results of a double-blind crossover study in healthy male subjects

Roessler G, Vobig M, Walter P, Mazinani BAE

Drug Design, Development and Therapy 2019, 13:37-43

Published Date: 18 December 2018

Multimetal organic frameworks as drug carriers: aceclofenac as a drug candidate

Al Haydar M, Abid HR, Sunderland B, Wang S

Drug Design, Development and Therapy 2019, 13:23-35

Published Date: 18 December 2018

Cytoprotective effects of molsidomine against methotrexate-induced hepatotoxicity: an experimental rat study

Samdanci ET, Huz M, Ozhan O, Tanbek K, Pamukcu E, Akatli AN, Parlakpinar H

Drug Design, Development and Therapy 2019, 13:13-21

Published Date: 20 December 2018