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Drug Design, Development and Therapy


Archive: Volume 15, 2021

Potential Mechanism of S. baicalensis on Lipid Metabolism Explored via Network Pharmacology and Untargeted Lipidomics

Ge PY, Qi YY, Qu SY, Zhao X, Ni S, Yao ZY, Guo R, Yang NY, Zhang QC, Zhu HX

Drug Design, Development and Therapy 2021, 15:1915-1930

Published Date: 4 May 2021

Protective Effects of Silymarin Against D-Gal/LPS-Induced Organ Damage and Inflammation in Mice

Zhao X, Wang H, Yang Y, Gou Y, Wang Z, Yang D, Li C

Drug Design, Development and Therapy 2021, 15:1903-1914

Published Date: 4 May 2021

Study on Hepatotoxicity of Rhubarb Based on Metabolomics and Network Pharmacology

Li S, Wang Y, Li C, Yang N, Yu H, Zhou W, Chen S, Yang S, Li Y

Drug Design, Development and Therapy 2021, 15:1883-1902

Published Date: 4 May 2021

Camrelizumab Combined with FOLFOX4 Regimen as First-Line Therapy for Advanced Hepatocellular Carcinomas: A Sub-Cohort of a Multicenter Phase Ib/II Study

Li H, Qin S, Liu Y, Chen Z, Ren Z, Xiong J, Meng Z, Zhang X, Wang L, Zhang X, Zou J

Drug Design, Development and Therapy 2021, 15:1873-1882

Published Date: 3 May 2021

Exosomal Circ-XIAP Promotes Docetaxel Resistance in Prostate Cancer by Regulating miR-1182/TPD52 Axis

Zhang H, Li M, Zhang J, Shen Y, Gui Q

Drug Design, Development and Therapy 2021, 15:1835-1849

Published Date: 3 May 2021

OSU-03012 Disrupts Akt Signaling and Prevents Endometrial Carcinoma Progression in vitro and in vivo

Ding L, Ren C, Yang L, Wu Z, Li F, Jiang D, Zhu Y, Lu J

Drug Design, Development and Therapy 2021, 15:1797-1810

Published Date: 30 April 2021

Integrating Network Pharmacology and Experimental Validation to Decipher the Mechanism of Action of Huanglian Jiedu Decoction in Treating Atherosclerosis

Liang J, Huang Y, Mai Z, Zhan Q, Lin H, Xie Y, Wang H, Liu Y, Luo C

Drug Design, Development and Therapy 2021, 15:1779-1795

Published Date: 30 April 2021

Alendronate Alleviated Femoral Head Necrosis and Upregulated BMP2/EIF2AK3/EIF2A/ATF4 Pathway in Liquid Nitrogen Treated Rats

Rong K, Li X, Jiang W, Wu X, Xia Q, Chen J, Yin X

Drug Design, Development and Therapy 2021, 15:1717-1724

Published Date: 23 April 2021

Rituximab Therapy for Treatment of Pemphigus in Southeast Asians

Kanokrungsee S, Anuntrangsee T, Tankunakorn J, Srisuwanwattana P, Suchonwanit P, Chanprapaph K

Drug Design, Development and Therapy 2021, 15:1677-1690

Published Date: 22 April 2021

Lactobacillus plantarum ZS62 Alleviates Alcohol-Induced Gastric Injury in Mice via an Anti-Oxidative Mechanism

Wu Y, Hu J, Long X, Pan Y, Mu J, Park KY, Zhao X

Drug Design, Development and Therapy 2021, 15:1667-1676

Published Date: 22 April 2021

Temozolomide-Induced Changes in Gut Microbial Composition in a Mouse Model of Brain Glioma

Li XC, Wu BS, Jiang Y, Li J, Wang ZF, Ma C, Li YR, Yao J, Jin XQ, Li ZQ

Drug Design, Development and Therapy 2021, 15:1641-1652

Published Date: 21 April 2021

Population Pharmacokinetics and Safety of Oral Tetra-Arsenic Tetra-Sulfide Formula in Pediatric Acute Promyelocytic Leukemia

Zhang L, Yang XM, Chen J, Hu L, Yang F, Zhou Y, Zhao BB, Zhao W, Zhu XF

Drug Design, Development and Therapy 2021, 15:1633-1640

Published Date: 21 April 2021

In vitro Preparation and Evaluation of Sustained-Release Microcapsules of Salvianolic Acid

Wang YH, Qu T, Wang XL, Yang RP

Drug Design, Development and Therapy 2021, 15:1623-1631

Published Date: 21 April 2021

Pharmacological Management of Gastro-Esophageal Reflux Disease: An Update of the State-of-the-Art

Savarino V, Marabotto E, Zentilin P, Demarzo MG, de Bortoli N, Savarino E

Drug Design, Development and Therapy 2021, 15:1609-1621

Published Date: 19 April 2021

An Ensemble Model for Prediction of Vancomycin Trough Concentrations in Pediatric Patients

Huang X, Yu Z, Bu S, Lin Z, Hao X, He W, Yu P, Wang Z, Gao F, Zhang J, Chen J

Drug Design, Development and Therapy 2021, 15:1549-1559

Published Date: 14 April 2021

Preparation Optimization of Bovine Serum Albumin Nanoparticles and Its Application for siRNA Delivery

Wang Y, Chen S, Yang X, Zhang S, Cui C

Drug Design, Development and Therapy 2021, 15:1531-1547

Published Date: 14 April 2021

Solasodine, Isolated from Solanum sisymbriifolium Fruits, Has a Potent Anti-Tumor Activity Against Pancreatic Cancer

Fan Y, Li Z, Wu L, Lin F, Shao J, Ma X, Yao Y, Zhuang W, Wang Y

Drug Design, Development and Therapy 2021, 15:1509-1519

Published Date: 13 April 2021

Pharmaceutical Development of 5-Fluorouracil-Eluting Stents for the Potential Treatment of Gastrointestinal Cancers and Related Obstructions

Arafat M, Song Y, Brewer K, Fouladian P, Parikh A, Albrecht H, Blencowe A, Garg S

Drug Design, Development and Therapy 2021, 15:1495-1507

Published Date: 9 April 2021

Low-Dose Triple Antihypertensive Combination Therapy in Patients with Hypertension: A Randomized, Double-Blind, Phase II Study [Corrigendum]

Hong SJ, Sung KC, Lim SW, Kim SY, Kim W, Shin J, Park S, Kim HY, Rhee MY

Drug Design, Development and Therapy 2021, 15:1477-1478

Published Date: 7 April 2021

Amino Acid Conjugates of Aminothiazole and Aminopyridine as Potential Anticancer Agents: Synthesis, Molecular Docking and in vitro Evaluation

Naz S, Shah FA, Nadeem H, sarwar S, Tan Z, Imran M, Ali T, Li JB, Li S

Drug Design, Development and Therapy 2021, 15:1459-1476

Published Date: 1 April 2021

White Tip Silver Needle (Slightly Fermented White Tea) Flavonoids Help Prevent Aging via Antioxidative and Anti-Inflammatory Effects

Li C, He J, Yang Y, Gou Y, Wang Z, Chen H, Zhao X

Drug Design, Development and Therapy 2021, 15:1441-1457

Published Date: 31 March 2021

The Risks of miRNA Therapeutics: In a Drug Target Perspective [Erratum]

Zhang S, Cheng Z, Wang Y, Han T

Drug Design, Development and Therapy 2021, 15:1423-1424

Published Date: 30 March 2021

Edaravone Alleviated Propofol-Induced Neurotoxicity in Developing Hippocampus by mBDNF/TrkB/PI3K Pathway

Yang Y, Yi J, Pan M, Hu B, Duan H

Drug Design, Development and Therapy 2021, 15:1409-1422

Published Date: 30 March 2021

Caspase Cascade Activation During Apoptotic Cell Death of Human Lung Carcinoma Cells A549 Induced by Marine Sponge Callyspongia aerizusa

Hadisaputri YE, Andika R, Sopyan I, Zuhrotun A, Maharani R, Rachmat R, Abdulah R

Drug Design, Development and Therapy 2021, 15:1357-1368

Published Date: 29 March 2021

Inhibitory Effects of Periplocin on Lymphoma Cells: A Network Pharmacology Approach and Experimental Validation

Zhao R, Han C, Dai S, Wei S, Xiang X, Wang Y, Zhao R, Zhao L, Shan B

Drug Design, Development and Therapy 2021, 15:1333-1344

Published Date: 26 March 2021

Nα-1, 3-Benzenedicarbonyl-Bis-(Amino Acid) and Dipeptide Candidates: Synthesis, Cytotoxic, Antimicrobial and Molecular Docking Investigation

Naglah AM, Moustafa GO, Elhenawy AA, Mounier MM, El-Sayed H, Al-Omar MA, Almehizia AA, Bhat MA

Drug Design, Development and Therapy 2021, 15:1315-1332

Published Date: 25 March 2021

Synthesis of Michael Adducts as Key Building Blocks for Potential Analgesic Drugs: In vitro, in vivo and in silico Explorations

Ahmad S, Mahnashi MH, Alyami BA, Alqahtani YS, Ullah F, Ayaz M, Tariq M, Sadiq A, Rashid U

Drug Design, Development and Therapy 2021, 15:1299-1313

Published Date: 23 March 2021

Application of Topical Immunotherapy in the Treatment of Alopecia Areata: A Review and Update

Mahasaksiri T, Kositkuljorn C, Anuntrangsee T, Suchonwanit P

Drug Design, Development and Therapy 2021, 15:1285-1298

Published Date: 23 March 2021

Role of p38 Mitogen-Activated Protein Kinase in Asthma and COPD: Pathogenic Aspects and Potential Targeted Therapies

Pelaia C, Vatrella A, Gallelli L, Lombardo N, Sciacqua A, Savino R, Pelaia G

Drug Design, Development and Therapy 2021, 15:1275-1284

Published Date: 23 March 2021

Study on the Mechanism of Jiawei Shengjiang Powder in Improving Male Asthma-Induced Asthenospermia Based on Network Pharmacology and Bioinformatics

Wang JS, Gong XF, Feng JL, Li HS, Li X, Deng S, Ren PZ, Wang JM, Lv MS, Jin RF, Chen QY, Wang B, Cui HS

Drug Design, Development and Therapy 2021, 15:1245-1259

Published Date: 19 March 2021

Drug Discovery and Development in Rare Diseases: Taking a Closer Look at the Tafamidis Story

Burton A, Castaño A, Bruno M, Riley S, Schumacher J, Sultan MB, See Tai S, Judge DP, Patel JK, Kelly JW

Drug Design, Development and Therapy 2021, 15:1225-1243

Published Date: 18 March 2021

Potential Anti-Coronavirus Agents and the Pharmacologic Mechanisms

Yang Y, Cui X, Wei H, Guo C, Zhang Y

Drug Design, Development and Therapy 2021, 15:1213-1223

Published Date: 17 March 2021

Repeated Doses of Ketamine Affect the Infant Rat Urogenital System

Kasıkara H, Sungu N, Arslan M, Kucuk A, Ozturk L, Afandiyeva N, Kavutcu M

Drug Design, Development and Therapy 2021, 15:1157-1165

Published Date: 11 March 2021

Antibacterial and Antimicrobial Effects of Xanthorrhizol in the Prevention of Dental Caries: A Systematic Review

Khalid GS, Hamrah MH, Ghafary ES, Hosseini S, Almasi F

Drug Design, Development and Therapy 2021, 15:1149-1156

Published Date: 11 March 2021

The Efficacy and Safety of Abrocitinib as a Treatment Option for Atopic Dermatitis: A Short Report of the Clinical Data

Napolitano M, Fabbrocini G, Ruggiero A, Marino V, Nocerino M, Patruno C

Drug Design, Development and Therapy 2021, 15:1135-1147

Published Date: 10 March 2021

Withanone from Withania somnifera Attenuates SARS-CoV-2 RBD and Host ACE2 Interactions to Rescue Spike Protein Induced Pathologies in Humanized Zebrafish Model

Balkrishna A, Pokhrel S, Singh H, Joshi M, Mulay VP, Haldar S, Varshney A

Drug Design, Development and Therapy 2021, 15:1111-1133

Published Date: 11 March 2021

Safety, Tolerability and Pharmacokinetics of Single and Multiple Ascending Doses of Benfotiamine in Healthy Subjects

Sheng L, Cao W, Lin P, Chen W, Xu H, Zhong C, Yuan F, Chen H, Li H, Liu C, Yang M, Li X

Drug Design, Development and Therapy 2021, 15:1101-1110

Published Date: 9 March 2021

Investigation of the Active Ingredients and Mechanism of Polygonum cuspidatum in Asthma Based on Network Pharmacology and Experimental Verification

Bi J, Lin YH, Sun Y, Zhang M, Chen Q, Miu X, Tang L, Liu J, Zhu L, Ni Z, Wang X

Drug Design, Development and Therapy 2021, 15:1075-1089

Published Date: 9 March 2021

An Overview of Bimekizumab for the Treatment of Psoriatic Arthritis: The Evidence so Far

G Oliveira D, Faria R, Torres T

Drug Design, Development and Therapy 2021, 15:1045-1053

Published Date: 9 March 2021

Role of Oxidative Stress and Reduced Endogenous Hydrogen Sulfide in Diabetic Nephropathy

Hussain Lodhi A, Ahmad FUD, Furwa K, Madni A

Drug Design, Development and Therapy 2021, 15:1031-1043

Published Date: 5 March 2021

Epigallocatechin-3-Gallate Promotes the in vitro Maturation and Embryo Development Following IVF of Porcine Oocytes

Huang K, Li C, Gao F, Fan Y, Zeng F, Meng L, Li L, Zhang S, Wei H

Drug Design, Development and Therapy 2021, 15:1013-1020

Published Date: 4 March 2021

The Effect of Nintedanib on T-Cell Activation, Subsets and Functions

Ubieta K, Thomas MJ, Wollin L

Drug Design, Development and Therapy 2021, 15:997-1011

Published Date: 8 March 2021

Dihydroartemisinin Inhibits TGF-β-Induced Fibrosis in Human Tenon Fibroblasts via Inducing Autophagy

Wang X, Song W, Zhang F, Huang R

Drug Design, Development and Therapy 2021, 15:973-981

Published Date: 3 March 2021

Characterization of Oxygenated Heterocyclic Compounds and in vitro Antioxidant Activity of Pomelo Essential Oil

Li G, Cheng Y, Zhang T, Li Y, Han L, Liang G

Drug Design, Development and Therapy 2021, 15:937-947

Published Date: 2 March 2021

Lidocaine Inhibits Myoblast Cell Migration and Myogenic Differentiation Through Activation of the Notch Pathway

Ling X, Ma X, Kuang X, Zou Y, Zhang H, Tang H, Du H, Zhu B, Huang H, Xia Q, Chen M, Mao D, Chen D, Shen H, Yan J

Drug Design, Development and Therapy 2021, 15:927-936

Published Date: 2 March 2021

Bitter Taste Receptor as a Therapeutic Target in Orthopaedic Disorders

Cheng W, Yao M, Liu F

Drug Design, Development and Therapy 2021, 15:895-903

Published Date: 26 February 2021

Low Frequency of Integrase Inhibitor Resistance Mutations Among Therapy-Naïve HIV Patients in Southeast China

Lai J, Liu Y, Han X, Huang A, Lin J, Ao W, Ye H, Chen Y

Drug Design, Development and Therapy 2021, 15:889-894

Published Date: 26 February 2021

Effects of Sugammadex versus Neostigmine on Intraoperative Coagulation Profiles in Patients with Thyroidectomy

Zhao D, Fang J, Xiong W, Lin J, Chen W, Wu C

Drug Design, Development and Therapy 2021, 15:829-834

Published Date: 25 February 2021

Efficacy and Safety of Retinol Palmitate Ophthalmic Solution in the Treatment of Dry Eye: A Japanese Phase II Clinical Trial [Corrigendum]

Toshida H, Funaki T, Ono K, Tabuchi N, Watanabe S, Seki T, Otake H, Kato T, Ebihara N, Murakami A

Drug Design, Development and Therapy 2021, 15:813-816

Published Date: 24 February 2021

Convallatoxin Promotes M2 Macrophage Polarization to Attenuate Atherosclerosis Through PPARγ-Integrin αvβ5 Signaling Pathway

Zhang Y, Shi X, Han J, Peng W, Fang Z, Zhou Y, Xu X, Lin J, Xiao F, Zhao L, Lin Y

Drug Design, Development and Therapy 2021, 15:803-812

Published Date: 23 February 2021

Mechanism of Action of Xiaoyao San in Treatment of Ischemic Stroke is Related to Anti-Apoptosis and Activation of PI3K/Akt Pathway

Xu Y, Chen W, Chen Z, Huang M, Yang F, Zhang Y

Drug Design, Development and Therapy 2021, 15:753-767

Published Date: 22 February 2021

The Effectiveness of Ruxolitinib for Acute/Chronic Graft-versus-Host Disease in Children: A Retrospective Study

Yang W, Zhu G, Qin M, Li Z, Wang B, Yang J, Wang T

Drug Design, Development and Therapy 2021, 15:743-752

Published Date: 22 February 2021

Addition of Celebrex and Pregabalin to Ropivacaine for Posterior Spinal Surgery: A Randomized, Double-Blinded, Placebo-Controlled Trial

Zhang Y, He B, Zhao J, Zhang M, Ren Q, Zhang W, Xu S, Quan Z, Ou Y

Drug Design, Development and Therapy 2021, 15:735-742

Published Date: 22 February 2021

The Risks of miRNA Therapeutics: In a Drug Target Perspective

Zhang S, Cheng Z, Wang Y, Han T

Drug Design, Development and Therapy 2021, 15:721-733

Published Date: 22 February 2021

Danggui Buxue Decoction in the Treatment of Metastatic Colon Cancer: Network Pharmacology Analysis and Experimental Validation

Feng SH, Zhao B, Zhan X, Motanyane R, Wang SM, Li A

Drug Design, Development and Therapy 2021, 15:705-720

Published Date: 24 February 2021

Glucocorticoid-Like Activity of Escin: A New Mechanism for an Old Drug

Gallelli L, Cione E, Wang T, Zhang L

Drug Design, Development and Therapy 2021, 15:699-704

Published Date: 24 February 2021

Trans-Cinnamaldehyde Increases Random Pattern Flap Survival Through Activation of the Nitric Oxide Pathway

Luo X, Zhao B, Chen B, Chen H, Han T, Bsoul NBN, Yan H

Drug Design, Development and Therapy 2021, 15:679-688

Published Date: 18 February 2021

Thiazole-Based Thiosemicarbazones: Synthesis, Cytotoxicity Evaluation and Molecular Docking Study

Gomha SM, Abdelhady HA, Hassain DZH, Abdelmonsef AH, El-Naggar M, Elaasser MM, Mahmoud HK

Drug Design, Development and Therapy 2021, 15:659-677

Published Date: 17 February 2021

Progress in Clinical Research on Gonadotropin-Releasing Hormone Receptor Antagonists for the Treatment of Prostate Cancer

Liu YF, Fu SQ, Yan YC, Gong BB, Xie WJ, Yang XR, Sun T, Ma M

Drug Design, Development and Therapy 2021, 15:639-649

Published Date: 16 February 2021

Effect of Different Dosage Frequency of Polymyxin B on Rat Nephrotoxicity

Sun W, Hu B, Zhang X, Wang Y, Xiang Z, Lin G

Drug Design, Development and Therapy 2021, 15:611-616

Published Date: 16 February 2021

Effects of Quercetin on the Efficacy of Various Chemotherapeutic Drugs in Cervical Cancer Cells

Xu W, Xie S, Chen X, Pan S, Qian H, Zhu X

Drug Design, Development and Therapy 2021, 15:577-588

Published Date: 15 February 2021

Self-Nanoemulsifying Drug Delivery System of Genkwanin: A Novel Approach for Anti-Colitis-Associated Colorectal Cancer

Yin HF, Yin CM, Ouyang T, Sun SD, Chen WG, Yang XL, He X, Zhang CF

Drug Design, Development and Therapy 2021, 15:557-576

Published Date: 12 February 2021

Magnesium Isoglycyrrhizinate Alleviates Arsenic Trioxide-Induced Cardiotoxicity: Contribution of Nrf2 and TLR4/NF-κB Signaling Pathway

Zheng B, Yang Y, Li J, Li J, Zuo S, Chu X, Xu S, Ma D, Chu L

Drug Design, Development and Therapy 2021, 15:543-556

Published Date: 12 February 2021

Synergistic Anticancer Strategy of Sonodynamic Therapy Combined with PI-103 Against Hepatocellular Carcinoma

Yang H, Jing H, Han X, Tan H, Cheng W

Drug Design, Development and Therapy 2021, 15:531-542

Published Date: 11 February 2021

L-Cysteine Provides Neuroprotection of Hypoxia-Ischemia Injury in Neonatal Mice via a PI3K/Akt-Dependent Mechanism

Li T, Li J, Li T, Zhao Y, Ke H, Wang S, Liu D, Wang Z

Drug Design, Development and Therapy 2021, 15:517-529

Published Date: 11 February 2021

Loganin Attenuates Septic Acute Renal Injury with the Participation of AKT and Nrf2/HO-1 Signaling Pathways

Zhang J, Wang C, Kang K, Liu H, Liu X, Jia X, Yu K

Drug Design, Development and Therapy 2021, 15:501-513

Published Date: 11 February 2021

EGCG Regulates Cell Apoptosis of Human Umbilical Vein Endothelial Cells Grown on 316L Stainless Steel for Stent Implantation

Wang J, Wang Y, Zhao Y, Zhao J, Zhang B, Xu K

Drug Design, Development and Therapy 2021, 15:493-499

Published Date: 11 February 2021

Profile of Enfortumab Vedotin in the Treatment of Urothelial Carcinoma: The Evidence to Date

Moussa M, Papatsoris A, Abou Chakra M, Dellis A

Drug Design, Development and Therapy 2021, 15:453-462

Published Date: 11 February 2021

Effect of Evodiamine on Rat Colonic Hypermotility Induced by Water Avoidance Stress and the Underlying Mechanism

Ren H, Yuan F, Tan W, Ding Y, An P, Luo H

Drug Design, Development and Therapy 2021, 15:441-452

Published Date: 10 February 2021

Design, Synthesis, Molecular Modelling, and Biological Evaluation of Oleanolic Acid-Arylidene Derivatives as Potential Anti-Inflammatory Agents

Hassan Mir R, Godavari G, Siddiqui NA, Ahmad B, Mothana RA, Ullah R, Almarfadi OM, Jachak SM, Masoodi MH

Drug Design, Development and Therapy 2021, 15:385-397

Published Date: 4 February 2021

Thiazolidine Derivatives Attenuate Carrageenan-Induced Inflammatory Pain in Mice

Malik Z, Abbas M, Al Kury LT, Shah FA, Alam M, Khan AU, Nadeem H, Alghamdi S, Sahibzada MUK, Li S

Drug Design, Development and Therapy 2021, 15:369-384

Published Date: 4 February 2021

Irisin Protects Against Hind Limb Ischemia Reperfusion Injury

Küçük A, Polat Y, Kılıçarslan A, Süngü N, Kartal H, Dursun AD, Arslan M

Drug Design, Development and Therapy 2021, 15:361-368

Published Date: 4 February 2021

New Approach in Ocular Drug Delivery: In vitro and ex vivo Investigation of Cyclodextrin-Containing, Mucoadhesive Eye Drop Formulations

Bíró T, Bocsik A, Jurišić Dukovski B, Gróf I, Lovrić J, Csóka I, Deli MA, Aigner Z

Drug Design, Development and Therapy 2021, 15:351-360

Published Date: 3 February 2021

CircNRIP1 Modulates the miR-515-5p/IL-25 Axis to Control 5-Fu and Cisplatin Resistance in Nasopharyngeal Carcinoma

Lin J, Qin H, Han Y, Li X, Zhao Y, Zhai G

Drug Design, Development and Therapy 2021, 15:323-330

Published Date: 27 January 2021

Phenotyping Study of Cyclophosphamide 4-Hydroxylation in Malay Cancer Patients

Fityatal Hasanah YI, Harahap Y, Purwanto DJ

Drug Design, Development and Therapy 2021, 15:305-313

Published Date: 26 January 2021

Physcion Protects Rats Against Cerebral Ischemia-Reperfusion Injury via Inhibition of TLR4/NF-kB Signaling Pathway

Dong X, Wang L, Song G, Cai X, Wang W, Chen J, Wang G

Drug Design, Development and Therapy 2021, 15:277-287

Published Date: 25 January 2021

Effects of Caffeic Acid and Its Derivatives on Bone: A Systematic Review

Ekeuku SO, Pang KL, Chin KY

Drug Design, Development and Therapy 2021, 15:259-275

Published Date: 22 January 2021

Paeoniflorin Sensitizes Breast Cancer Cells to Tamoxifen by Downregulating microRNA-15b via the FOXO1/CCND1/β-Catenin Axis

Wang Y, Wang Q, Li X, Luo G, Shen M, Shi J, Wang X, Tang L

Drug Design, Development and Therapy 2021, 15:245-257

Published Date: 22 January 2021

Gracillin Isolated from Reineckia carnea Induces Apoptosis of A549 Cells via the Mitochondrial Pathway

Yang J, Cao L, Li Y, Liu H, Zhang M, Ma H, Wang B, Yuan X, Liu Q

Drug Design, Development and Therapy 2021, 15:233-243

Published Date: 20 January 2021

Galangin Improved Non-Alcoholic Fatty Liver Disease in Mice by Promoting Autophagy [Corrigendum]

Zhang X, Deng Y, Xiang J, Liu H, Zhang J, Liao J, Chen K, Liu B, Liu J, Pu Y

Drug Design, Development and Therapy 2021, 15:231-232

Published Date: 20 January 2021

Clinical Significance of Continuable Treatment with Nintedanib Over 12 Months for Idiopathic Pulmonary Fibrosis in a Real-World Setting

Kato M, Sasaki S, Tateyama M, Arai Y, Motomura H, Sumiyoshi I, Ochi Y, Watanabe J, Ihara H, Togo S, Takahashi K

Drug Design, Development and Therapy 2021, 15:223-230

Published Date: 18 January 2021

H2O2-Inactivated Salmonella typhimurium RE88 Strain as a New Cancer Vaccine Carrier: Evaluation in a Mouse Model of Cancer

Fan Y, Bai T, Tian Y, Zhou B, Wang Y, Yang L

Drug Design, Development and Therapy 2021, 15:209-222

Published Date: 15 January 2021

Quaternary Lidocaine Derivatives: Past, Present, and Future

Wang Q, Zhang Y, Liu J, Zhang W

Drug Design, Development and Therapy 2021, 15:195-207

Published Date: 14 January 2021

Bioequivalence and Pharmacokinetic Profiles of Generic and Branded Obeticholic Acid in Healthy Chinese Subjects Under Fasting and Fed Conditions

Wang MN, Yu HT, Li YQ, Zeng Y, Yang S, Yang GP, Pei Q, Huang J

Drug Design, Development and Therapy 2021, 15:185-193

Published Date: 14 January 2021

Combination of Sodium Cantharidinate with Cisplatin Synergistically Hampers Growth of Cervical Cancer

Chen X, Zhou M, Fan W, Yang M, Yang L

Drug Design, Development and Therapy 2021, 15:171-183

Published Date: 13 January 2021

Subcutaneous Delivery of High-Dose/Volume Biologics: Current Status and Prospect for Future Advancements

Badkar AV, Gandhi RB, Davis SP, LaBarre MJ

Drug Design, Development and Therapy 2021, 15:159-170

Published Date: 13 January 2021

Capsaicin Inhibits Proliferation and Induces Apoptosis in Breast Cancer by Down-Regulating FBI-1-Mediated NF-κB Pathway

Chen M, Xiao C, Jiang W, Yang W, Qin Q, Tan Q, Lian B, Liang Z, Wei C

Drug Design, Development and Therapy 2021, 15:125-140

Published Date: 12 January 2021

Chronic Obstructive Pulmonary Disease Treatment and Pharmacist-Led Medication Management

Li LC, Han YY, Zhang ZH, Zhou WC, Fang HM, Qu J, Kan LD

Drug Design, Development and Therapy 2021, 15:111-124

Published Date: 12 January 2021

Network Pharmacology and Experimental Evidence Identify the Mechanism of Astragaloside IV in Oxaliplatin Neurotoxicity

Xu J, Guan Z, Wang X, Sun D, Li Y, Pei B, Lu Y, Yuan L, Zhang X

Drug Design, Development and Therapy 2021, 15:99-110

Published Date: 12 January 2021

A Review of Drug Therapy in Vestibular Schwannoma

Long J, Zhang Y, Huang X, Ren J, Zhong P, Wang B

Drug Design, Development and Therapy 2021, 15:75-85

Published Date: 8 January 2021

Inhibition of Pre-B Cell Colony Enhancing Factor Reduces Lung Injury in Rats Receiving Cardiopulmonary Bypass

Lu C, Yang W, Zhou J, Zhang Z, Gong Y, Hu F, Yu W, Dong X

Drug Design, Development and Therapy 2021, 15:51-60

Published Date: 7 January 2021

RASSF1A Enhances Chemosensitivity of NSCLC Cells Through Activating Autophagy by Regulating MAP1S to Inactivate Keap1-Nrf2 Pathway

Wang J, Zhang X, Yang F, Yang Y, Wang T, Liu W, Zhou H, Zhao W

Drug Design, Development and Therapy 2021, 15:21-35

Published Date: 6 January 2021

Current Status and Perspectives of Protease Inhibitors and Their Combination with Nanosized Drug Delivery Systems for Targeted Cancer Therapy

Rudzińska M, Daglioglu C, Savvateeva LV, Kaci FN, Antoine R, Zamyatnin Jr AA

Drug Design, Development and Therapy 2021, 15:9-20

Published Date: 6 January 2021