Back to Journals » Drug Design, Development and Therapy » Volume 16

Drug Design, Development and Therapy

ISSN: 1177-8881


Archive: Volume 16, 2022

Risk Factors for Hepatic Encephalopathy in Hepatocellular Carcinoma After Sorafenib or Lenvatinib Treatment: A Real-World Study

Chen B, Zhang L, Cheng J, Wu T, Lei J, Yang X, Zhang R, Safadi R, Li Y, Si T, Lu Y

Drug Design, Development and Therapy 2022, 16:4429-4437

Published Date: 28 December 2022

Notoginsenoside R1 Promotes Proliferation and Osteogenic Differentiation of hPDLSCs via Wnt/β-Catenin Signaling Pathway

Han R, Zhang W, Zhang L, Zou J, Yang Y, Li H, Zhang J

Drug Design, Development and Therapy 2022, 16:4399-4409

Published Date: 23 December 2022

Chemical Chaperones to Inhibit Endoplasmic Reticulum Stress: Implications in Diseases

Jeon JH, Im S, Kim HS, Lee D, Jeong K, Ku JM, Nam TG

Drug Design, Development and Therapy 2022, 16:4385-4397

Published Date: 23 December 2022

Anti-Inflammatory Activation of Phellodendri Chinensis Cortex is Mediated by Berberine Erythrocytes Self-Assembly Targeted Delivery System

Li M, Qin Z, Yu Q, Huang Z, Cheng J, Zhong L, Liu Y, Xie J, Li Y, Chen J, Zhan R, Su Z

Drug Design, Development and Therapy 2022, 16:4365-4383

Published Date: 23 December 2022

Antiviral Activity of Oridonin Against Herpes Simplex Virus Type 1

Jiang K, Feng J, Qi X, Ran L, Xie L

Drug Design, Development and Therapy 2022, 16:4311-4323

Published Date: 20 December 2022

Effect of Rifampicin on the Pharmacokinetics of Evogliptin in Healthy Volunteers

Shin Y, Choi C, Oh ES, Kim CO, Park K, Park MS

Drug Design, Development and Therapy 2022, 16:4301-4310

Published Date: 20 December 2022

Design and Optimization of Rivaroxaban-Cyclodextrin-Polymer Triple Complex Formulation with Improved Solubility

Kang JH, Lee JE, Jeong SJ, Park CW, Kim DW, Weon KY

Drug Design, Development and Therapy 2022, 16:4279-4289

Published Date: 16 December 2022

Development, in vitro Evaluation, and in vivo Study of Adhesive Buccal Films for the Treatment of Diabetic Pediatrics via Trans Mucosal Delivery of Gliclazide

Gaber DA, Alburaykan AI, Alruthea LM, Aldohan NS, Alharbi RF, Aljohani AR, Albilaihi HM, Adogim SS

Drug Design, Development and Therapy 2022, 16:4235-4250

Published Date: 13 December 2022

Canagliflozin Attenuates Hepatic Steatosis and Atherosclerosis Progression in Western Diet-Fed ApoE-Knockout Mice

Zuo Q, Zhang G, He L, Ma S, Ma H, Zhai J, Wang Z, Zhang T, Wang Y, Guo Y

Drug Design, Development and Therapy 2022, 16:4161-4177

Published Date: 6 December 2022

Effect of Remimazolam Tosilate on Respiratory Depression in Elderly Patients Undergoing Gastroscopy: A Multicentered, Prospective, and Randomized Study

Hu B, Jiang K, Shi W, Xiao S, Zhang S, Zhang Y, Zhou Y, Tan C, Tan S, Zou X

Drug Design, Development and Therapy 2022, 16:4151-4159

Published Date: 5 December 2022

Thalidomide Attenuates Skin Lesions and Inflammation in Rosacea-Like Mice Induced by Long-Term Exposure of LL-37

Kang Y, Zhang C, He Y, Zhang Z, Liu H, Wei Z, Yang J

Drug Design, Development and Therapy 2022, 16:4127-4138

Published Date: 2 December 2022

Liquiritin Protects Against Cardiac Fibrosis After Myocardial Infarction by Inhibiting CCL5 Expression and the NF-κB Signaling Pathway

Han X, Yang Y, Zhang M, Li L, Xue Y, Jia Q, Wang X, Guan S

Drug Design, Development and Therapy 2022, 16:4111-4125

Published Date: 2 December 2022

Remimazolam Tosylate Combined with Low-Dose Propofol Improves Sedation and Safety in Hysteroscopy

Zhang F, Chang H, Qing W, Yu R, Liao Q, Tong J

Drug Design, Development and Therapy 2022, 16:4101-4108

Published Date: 29 November 2022

Integrated Network Pharmacology Analysis and Experimental Validation to Investigate the Molecular Mechanism of Triptolide in the Treatment of Membranous Nephropathy

Zhang PN, Tang JY, Yang KZ, Zheng QY, Dong ZC, Geng YL, Liu YN, Liu WJ

Drug Design, Development and Therapy 2022, 16:4061-4076

Published Date: 23 November 2022

Design of 1,4-Dihydropyridine Hybrid Benzamide Derivatives: Synthesis and Evaluation of Analgesic Activity and Their Molecular Docking Studies

Akbar I, Radhakrishnan S, Karpakavalli M, Manilal A, Hatamleh AA, Alnafisi BK, Ahamed A, Balasubramani R

Drug Design, Development and Therapy 2022, 16:4021-4039

Published Date: 21 November 2022

Decoding the Key Functional Combined Components Group and Uncovering the Molecular Mechanism of Longdan Xiegan Decoction in Treating Uveitis

Zheng YX, Wang KX, Chen SJ, Liao MX, Chen YP, Guan DG, Wu J, Xiong K

Drug Design, Development and Therapy 2022, 16:3991-4011

Published Date: 17 November 2022

Remimazolam: An Updated Review of a New Sedative and Anaesthetic

Hu Q, Liu X, Wen C, Li D, Lei X

Drug Design, Development and Therapy 2022, 16:3957-3974

Published Date: 15 November 2022

ED-71 Prevents Glucocorticoid-Induced Osteoporosis by Regulating Osteoblast Differentiation via Notch and Wnt/β-Catenin Pathways

Rong X, Kou Y, Zhang Y, Yang P, Tang R, Liu H, Li M

Drug Design, Development and Therapy 2022, 16:3929-3946

Published Date: 15 November 2022

Metabolomics Provides Insights into Renoprotective Effects of Semaglutide in Obese Mice

Chen X, Chen S, Ren Q, Niu S, Pan X, Yue L, Li Z, Zhu R, Jia Z, Chen X, Zhen R, Ban J

Drug Design, Development and Therapy 2022, 16:3893-3913

Published Date: 9 November 2022

Comparative Pharmacokinetics and Safety of Imrecoxib, a Novel Selective Cyclooxygenase-2 Inhibitor, in Elderly Healthy Subjects

Yang L, Shen Q, Hu C, Wang Y, Zhu X, Shu S, Luo Z

Drug Design, Development and Therapy 2022, 16:3865-3876

Published Date: 8 November 2022

Screening of Adapalene Microsponges Fabrication Parameters with Insight on the In vitro Biological Effectiveness

Yehia RM, Attia DA, Elmazar MM, El-Nabarawi MA, Teaima MH

Drug Design, Development and Therapy 2022, 16:3847-3864

Published Date: 4 November 2022

Biological Mechanisms and Related Natural Inhibitors of CD36 in Nonalcoholic Fatty Liver

Feng Y, Sun W, Sun F, Yin G, Liang P, Chen S, Liu X, Jiang T, Zhang F

Drug Design, Development and Therapy 2022, 16:3829-3845

Published Date: 4 November 2022

Targeting mTOR Complex 2 in Castration-Resistant Prostate Cancer with Acquired Docetaxel Resistance

Huang Y, Zhai Y, Wu M, Chang C, Luo J, Hong D, Zhao Q, Dai Y, Liu J

Drug Design, Development and Therapy 2022, 16:3817-3828

Published Date: 4 November 2022

Madecassic Acid Ameliorates the Progression of Osteoarthritis: An in vitro and in vivo Study

Fu X, He S, Wang L, Xue Y, Qiao S, An J, Xia T

Drug Design, Development and Therapy 2022, 16:3793-3804

Published Date: 1 November 2022

Integrated Metabonomics and Network Pharmacology to Reveal the Action Mechanism Effect of Shaoyao Decoction on Ulcerative Colitis

Wu J, Luo Y, Shen Y, Hu Y, Zhu F, Wu J, Liu Y

Drug Design, Development and Therapy 2022, 16:3739-3776

Published Date: 27 October 2022

Switching from a Non-Protease Inhibitor-Based Regimen to the Fixed Dose Combination of Darunavir/Cobicistat/Emtricitabine/Tenofovir Alafenamide in Clinical Practice [Corrigendum]

Ranzenigo M, Gianotti N, Galli L, Poli A, Mastrangelo A, Bruzzesi E, Chiurlo M, Nozza S, Bossolasco S, Spagnuolo V, Mancusi D, Termini R, Carini E, Lazzarin A, Castagna A

Drug Design, Development and Therapy 2022, 16:3737-3738

Published Date: 27 October 2022

Sufentanil Combined with Nalbuphine via Patient-Controlled Intravenous Analgesia After Cesarean Section: A Retrospective Evaluation

Wang L, Wang Y, Ma Y, Mu X, Zhang Z, Wang H, Zheng Z, Nie H

Drug Design, Development and Therapy 2022, 16:3711-3721

Published Date: 21 October 2022

A Review of Population Pharmacokinetic Models of Posaconazole

Ding Q, Huang S, Sun Z, Chen K, Li X, Pei Q

Drug Design, Development and Therapy 2022, 16:3691-3709

Published Date: 20 October 2022

Chikungunya Vaccine Candidates: Current Landscape and Future Prospects

Schmidt C, Schnierle BS

Drug Design, Development and Therapy 2022, 16:3663-3673

Published Date: 20 October 2022

Impact of Remdesivir on SARS-CoV-2 Clearance in a Real-Life Setting: A Matched-Cohort Study

Spagnuolo V, Voarino M, Tonelli M, Galli L, Poli A, Bruzzesi E, Racca S, Clementi N, Oltolini C, Tresoldi M, Rovere Querini P, Dagna L, Zangrillo A, Ciceri F, Clementi M, Castagna A

Drug Design, Development and Therapy 2022, 16:3645-3654

Published Date: 19 October 2022

Smilax glabra Roxb.: A Review of Its Traditional Usages, Phytochemical Constituents, Pharmacological Properties, and Clinical Applications

Wu H, Wang Y, Zhang B, Li YL, Ren ZX, Huang JJ, Zhang ZQ, Lin ZJ, Zhang XM

Drug Design, Development and Therapy 2022, 16:3621-3643

Published Date: 19 October 2022

Management of Axial Spondyloarthritis – Insights into Upadacitinib

Braun J, Kiltz U, Baraliakos X

Drug Design, Development and Therapy 2022, 16:3609-3620

Published Date: 19 October 2022

Exosomes Derived from Hypoxic Glioma Cells Reduce the Sensitivity of Glioma Cells to Temozolomide Through Carrying miR-106a-5p

Wu P, Guo J, Yang H, Yuan D, Wang C, Wang Z

Drug Design, Development and Therapy 2022, 16:3589-3598

Published Date: 13 October 2022

A Review of Herbal Medicine-Based Phytochemical of Garcinia as Molecular Therapy for Breast Cancer

Triyasa KS, Diantini A, Barliana MI

Drug Design, Development and Therapy 2022, 16:3573-3588

Published Date: 12 October 2022

Semaglutide May Alleviate Hepatic Steatosis in T2DM Combined with NFALD Mice via miR-5120/ABHD6

Li R, Ye Z, She D, Fang P, Zong G, Hu K, Kong D, Xu W, Li L, Zhou Y, Zhang K, Xue Y

Drug Design, Development and Therapy 2022, 16:3557-3572

Published Date: 12 October 2022

The Novel Compounds with Biological Activity Derived from Soil Fungi in the Past Decade

Zhang D, Li S, Fan M, Zhao C

Drug Design, Development and Therapy 2022, 16:3493-3555

Published Date: 12 October 2022

Efficacy of Chloral Hydrate Oral Solution for Sedation in Pediatrics: a Systematic Review and Meta-Analysis [Corrigendum]

Chen Z, Lin M, Huang Z, Zeng L, Huang L, Yu D, Zhang L

Drug Design, Development and Therapy 2022, 16:3491-3492

Published Date: 11 October 2022

Preparation, in vitro and in vivo Evaluation of Thermosensitive in situ Gel Loaded with Ibuprofen-Solid Lipid Nanoparticles for Rectal Delivery [Retraction]

Huang CH, Hu PY, Wu QY, Xia MY, Zhang WL, Lei ZQ, Li DX, Zhang GS, Feng JF

Drug Design, Development and Therapy 2022, 16:3445-3446

Published Date: 6 October 2022

Profile of Remimazolam in Anesthesiology: A Narrative Review of Clinical Research Progress

Wang M, Zhao X, Yin P, Bao X, Tang H, Kang X

Drug Design, Development and Therapy 2022, 16:3431-3444

Published Date: 3 October 2022

Pharmacokinetics of Herb-Drug Interactions of Plumbagin and Tazemetostat in Rats by UPLC-MS/MS

Li H, Wang YJ, Geng XN, Kang YR, Wang YL, Qiu XJ

Drug Design, Development and Therapy 2022, 16:3385-3394

Published Date: 29 September 2022

Protective Effects of p-CA Against Acute Liver Damage Induced by LPS/D-GalN in Wistar Albino Rats

Mehdi S, Ahmad FUD, Lodhi AH, Khurshid U, Khalid AA, Sidiq SS, Hussain L, Baig MS

Drug Design, Development and Therapy 2022, 16:3327-3342

Published Date: 28 September 2022

Network and Experimental Pharmacology to Decode the Action of Wendan Decoction Against Generalized Anxiety Disorder

Jin Q, Li J, Chen GY, Wu ZY, Liu XY, Liu Y, Chen L, Wu XY, Liu Y, Zhao X, Song YH

Drug Design, Development and Therapy 2022, 16:3297-3314

Published Date: 27 September 2022

Synthesis and Bioactivity Evaluation of a Novel 1,2,4-Oxadiazole Derivative in vitro and in 3×Tg Mice

Luo Z, Wang Y, Pang S, Gao S, Liu N, Gao X, Zhang L, Qi X, Yang Y, Zhang L

Drug Design, Development and Therapy 2022, 16:3285-3296

Published Date: 25 September 2022

Non-Inferior Efficacy of Tenofovir Disoproxil to Tenofovir Disoproxil Fumarate in Virologically Suppressed Chronic Hepatitis B Patients

Yim HJ, Kim JH, Cho YK, Kweon YO, Cho HC, Hwang JS, Lee C, Koh MS, Baek YH, Park YM, Lee JH, Kim SU, Kang MK, Park NH, Lee JS, Chon YE, Cheon GJ, Chae HB, Sohn JH, Lim YS

Drug Design, Development and Therapy 2022, 16:3263-3274

Published Date: 23 September 2022

Ibrutinib-Associated Cardiotoxicity: From the Pharmaceutical to the Clinical

Dong R, Yan Y, Zeng X, Lin N, Tan B

Drug Design, Development and Therapy 2022, 16:3225-3239

Published Date: 20 September 2022

Effect of Weight-Adjusted Phenylephrine, Norepinephrine, and Metaraminol for Elective Cesarean Delivery on Neonatal Acid–Base Status: A Randomized Controlled Trial

Liu T, Cheng Z, Zou S, Xu C, Pan S, Zeng H, Shan Y, Feng Y, Zhang H

Drug Design, Development and Therapy 2022, 16:3215-3223

Published Date: 21 September 2022

Combined Treatment of Tanshinone I and Epirubicin Revealed Enhanced Inhibition of Hepatocellular Carcinoma by Targeting PI3K/AKT/HIF-1α

Zhao J, Lin E, Cai C, Zhang M, Li D, Cai S, Zeng G, Yin Z, Wang B, Li P, Hong X, Chen J, Zou B, Li J

Drug Design, Development and Therapy 2022, 16:3197-3213

Published Date: 19 September 2022

Cyclosporine A (0.05%) Ophthalmic Gel in the Treatment of Dry Eye Disease: A Multicenter, Randomized, Double-Masked, Phase III, COSMO Trial

Peng W, Jiang X, Zhu L, Li X, Zhou Q, Jie Y, You Z, Wu M, Jin X, Li X, Zhou S

Drug Design, Development and Therapy 2022, 16:3183-3194

Published Date: 20 September 2022

Guanmaitong Granule Attenuates Atherosclerosis by Inhibiting Inflammatory Immune Response in ApoE−/− Mice Fed High-Fat Diet

Yang M, Jiao H, Li Y, Zhang L, Zhang J, Zhong X, Xue Y

Drug Design, Development and Therapy 2022, 16:3145-3168

Published Date: 16 September 2022

Preclinical Pharmacokinetics, Tissue Distribution and in vitro Metabolism of FHND6091, a Novel Oral Proteasome Inhibitor

Yang X, Liu A, Yang L, Wen T, Wang J, Shi J, Zhou H, Chen Z, Lei M, Zhu Y

Drug Design, Development and Therapy 2022, 16:3087-3107

Published Date: 13 September 2022

Dihydromyricetin Attenuates Cerebral Ischemia Reperfusion Injury by Inhibiting SPHK1/mTOR Signaling and Targeting Ferroptosis

Xie J, Zhang T, Li P, Wang D, Liu T, Xu S

Drug Design, Development and Therapy 2022, 16:3071-3085

Published Date: 11 September 2022

Dioscin Regulating Bone Marrow Apoptosis in Aplastic Anemia

Zhang L, Ni R, Li J, Fan L, Song Y, Wang H, Wang A, Liu B

Drug Design, Development and Therapy 2022, 16:3041-3053

Published Date: 8 September 2022

Alpha-Chymotrypsin Protects Against Acute Lung, Kidney, and Liver Injuries and Increases Survival in CLP-Induced Sepsis in Rats Through Inhibition of TLR4/NF-κB Pathway

Senousy SR, Ahmed ASF, Abdelhafeez DA, Khalifa MMA, Abourehab MAS, El-Daly M

Drug Design, Development and Therapy 2022, 16:3023-3039

Published Date: 8 September 2022

Identification of Drug Combination Therapies for SARS-CoV-2: A Molecular Dynamics Simulations Approach

Abdel-Halim H, Hajar M, Hasouneh L, Abdelmalek SMA

Drug Design, Development and Therapy 2022, 16:2995-3013

Published Date: 9 September 2022

Levistilide a Induces Ferroptosis by Activating the Nrf2/HO-1 Signaling Pathway in Breast Cancer Cells

Jing S, Lu Y, Zhang J, Ren Y, Mo Y, Liu D, Duan L, Yuan Z, Wang C, Wang Q

Drug Design, Development and Therapy 2022, 16:2981-2993

Published Date: 7 September 2022

Sinomenine Inhibits Orthodontic Tooth Movement and Root Resorption in Rats and Enhances Osteogenic Differentiation of PDLSCs

Li H, Li Y, Zou J, Yang Y, Han R, Zhang J

Drug Design, Development and Therapy 2022, 16:2949-2965

Published Date: 5 September 2022

Oral Selective Estrogen Receptor Degraders (SERDs) in Breast Cancer: Advances, Challenges, and Current Status

Downton T, Zhou F, Segara D, Jeselsohn R, Lim E

Drug Design, Development and Therapy 2022, 16:2933-2948

Published Date: 2 September 2022

Protective Effects of Pioglitazone on Cognitive Impairment and the Underlying Mechanisms: A Review of Literature

Alhowail A, Alsikhan R, Alsaud M, Aldubayan M, Rabbani SI

Drug Design, Development and Therapy 2022, 16:2919-2931

Published Date: 31 August 2022

Characterization of Selective and Potent JAK1 Inhibitors Intended for the Inhaled Treatment of Asthma

Nilsson M, Rhedin M, Hendrickx R, Berglund S, Piras A, Blomgran P, Cavallin A, Collins M, Dahl G, Dekkak B, Ericsson T, Hagberg N, Holmberg AA, Leffler A, Lundqvist AJ, Markou T, Pinkerton J, Rönnblom L, Siu S, Taylor V, Wennberg T, Zervas D, Laurence ADJ, Mitra S, Belvisi MG, Birrell M, Borde A

Drug Design, Development and Therapy 2022, 16:2901-2917

Published Date: 31 August 2022

Effect of Puerarin on Osteogenic Differentiation in vitro and on New Bone Formation in vivo

Yang Y, Chen D, Li Y, Zou J, Han R, Li H, Zhang J

Drug Design, Development and Therapy 2022, 16:2885-2900

Published Date: 27 August 2022

Effects of Lactobacillus plantarum HFY15 on Lupus Nephritis in Mice by Regulation of the TGF-β1 Signaling Pathway

Cheng L, Yao P, Wang H, Yuan Q, Wang X, Feng W, Sun F, Wang Q

Drug Design, Development and Therapy 2022, 16:2851-2860

Published Date: 26 August 2022

Mahuang Decoction Attenuates Airway Inflammation and Remodeling in Asthma via Suppression of the SP1/FGFR3/PI3K/AKT Axis

Wei L, Gou X, Su B, Han H, Guo T, Liu L, Wang L, Zhang L, Chen W

Drug Design, Development and Therapy 2022, 16:2833-2850

Published Date: 26 August 2022

Tackling Microbial Resistance with Isatin-Decorated Thiazole Derivatives: Design, Synthesis, and in vitro Evaluation of Antimicrobial and Antibiofilm Activity

Kassab RM, Al-Hussain SA, Elleboudy NS, Albohy A, Zaki MEA, Abouzid KAM, Muhammad ZA

Drug Design, Development and Therapy 2022, 16:2817-2832

Published Date: 25 August 2022

SIRT1/FOXO1 Axis-Mediated Hippocampal Angiogenesis is Involved in the Antidepressant Effect of Chaihu Shugan San

Zhang S, Lu Y, Shi W, Ren Y, Xiao K, Chen W, Li L, Zhao J

Drug Design, Development and Therapy 2022, 16:2783-2801

Published Date: 23 August 2022

Ginsenoside Rd Promotes Cardiac Repair After Myocardial Infarction by Modulating Monocytes/Macrophages Subsets Conversion

Zhao T, Wang X, Liu Q, Yang T, Qu H, Zhou H

Drug Design, Development and Therapy 2022, 16:2767-2782

Published Date: 22 August 2022

A Real-World Study on the Effect of Imrecoxib for Patients with Axial Spondyloarthritis

Zong HX, Xu SQ, Wang JX, Chu YR, Chen K, Wang C, Tong WQ, Wang XL

Drug Design, Development and Therapy 2022, 16:2755-2765

Published Date: 22 August 2022

Recent Advances in Nano-Formulations for Skin Wound Repair Applications

Lin Y, Chen Z, Liu Y, Wang J, Lv W, Peng R

Drug Design, Development and Therapy 2022, 16:2707-2728

Published Date: 16 August 2022

Intravenous Lidocaine Significantly Reduces the Propofol Dose in Elderly Patients Undergoing Gastroscopy: A Randomized Controlled Trial

Hu S, Wang M, Li S, Zhou W, Zhang Y, Shi H, Ye P, Sun J, Liu F, Zhang W, Zheng L, Hou Q, Wang Y, Sun W, Chen Y, Lu Z, Ji Z, Liao L, Lv X, Wang Y, Wang X, Yang H

Drug Design, Development and Therapy 2022, 16:2695-2705

Published Date: 12 August 2022

Brolucizumab for the Treatment of Degenerative Macular Conditions: A Review of Clinical Studies

Karasavvidou EM, Tranos P, Panos GD

Drug Design, Development and Therapy 2022, 16:2659-2680

Published Date: 9 August 2022

Targeting Indoleamine Dioxygenase and Tryptophan Dioxygenase in Cancer Immunotherapy: Clinical Progress and Challenges

Peng X, Zhao Z, Liu L, Bai L, Tong R, Yang H, Zhong L

Drug Design, Development and Therapy 2022, 16:2639-2657

Published Date: 8 August 2022

The Preventive and Therapeutic Effects of Ajwa Date Fruit Extract Against Acute Diclofenac Toxicity-Induced Colopathy: An Experimental Study

Hassan SMA, Aboonq MS, Albadawi EA, Aljehani Y, Abdel-Latif HM, Mariah RA, Shafik NM, Soliman TM, Abdel-Gawad AR, Omran FM, Abdellah WA, Shehata A, Shahada H, Baghdadi HH, Aly HY, Saad A, Nabo MMH, Almilaibary A, Eltahir HM, El Sayed SM, Abu-Elnaga MAM, Elbastawisy YM

Drug Design, Development and Therapy 2022, 16:2601-2616

Published Date: 6 August 2022

The Extract of Ilex cornuta Bark Promotes Bone Healing by Activating Adenosine A2A Receptor

Zheng X, Wang J, Zhou J, Wang D

Drug Design, Development and Therapy 2022, 16:2569-2587

Published Date: 4 August 2022

Pleiotropic Effects of Ticagrelor: Influence on CYP4F2 Gene and Protein Expression in HUVEC and HepG2, and Escherichia coli Bacterial Survival

Meskauskaite U, Andruskeviciute S, Ciapiene I, Giedraitiene A, Lesauskaite V, Tatarunas V

Drug Design, Development and Therapy 2022, 16:2559-2568

Published Date: 4 August 2022

Effects of Uremic Clearance Granules on p38 MAPK/NF-κB Signaling Pathway, Microbial and Metabolic Profiles in End-Stage Renal Disease Rats Receiving Peritoneal Dialysis

Li X, Zheng J, Wang J, Tang X, Zhang F, Liu S, Liao Y, Chen X, Xie W, Tang Y

Drug Design, Development and Therapy 2022, 16:2529-2544

Published Date: 3 August 2022

Trimetazidine Reduces Cardiac Fibrosis in Rats by Inhibiting NOX2-Mediated Endothelial-to-Mesenchymal Transition

Chen X, Xia X, Dong T, Lin Z, Du L, Zhou H

Drug Design, Development and Therapy 2022, 16:2517-2527

Published Date: 3 August 2022

Anti-Inflammatory Effects and Molecular Mechanisms of Shenmai Injection in Treating Acute Pancreatitis: Network Pharmacology Analysis and Experimental Verification

He Y, Hu C, Liu S, Xu M, Liang G, Du D, Liu T, Cai F, Chen Z, Tan Q, Deng L, Xia Q

Drug Design, Development and Therapy 2022, 16:2479-2495

Published Date: 2 August 2022

The Role of Histone H3 Methylation in Acute Kidney Injury

Zhao YB, Wei W, Lin XX, Chai YF, Jin H

Drug Design, Development and Therapy 2022, 16:2453-2461

Published Date: 2 August 2022

Induction of Apoptosis and Autophagy via sirtuin1- and PI3K/Akt/mTOR-Mediated Pathways by Plumbagin in Human Prostate Cancer Cells [Retraction]

Zhou Z, Li X, He Z, Pan S, Yang Y, Zhang X, Chow K, Yang T, Qiu J, Zhou Q, Tan J, Wang D, Zhou S

Drug Design, Development and Therapy 2022, 16:2437-2438

Published Date: 29 July 2022

Study of the Mechanism of Antiemetic Effect of Lavandula angustifolia Mill. Essential Oil Based on Ca2+/CaMKII/ERK1/2 Pathway

Li J, Wang X, Xun S, Guo Q, Wang Y, Jia Y, Wang W, Wang Y, Li T, Tang T, Zou J, Wang M, Yang M, Wang F, Zhang X, Wang C

Drug Design, Development and Therapy 2022, 16:2407-2422

Published Date: 26 July 2022

A Novel Delivery System of RGD-HSA Loaded GEM/CUR Nanoparticles for the Treatment of Pancreatic Cancer Therapy

Ma T, Jiang JL, Qi WX, Chen JY, Xu HP

Drug Design, Development and Therapy 2022, 16:2395-2406

Published Date: 26 July 2022

Pharmacokinetic Study of Nalbuphine in Surgical Patients Undergoing General Anesthesia with Varying Degrees of Liver Dysfunction

Gao XN, Nie XY, Gao JL, Heng TF, Zhang YQ, Hua L, Sun YQ, Feng ZY, Wang MX, Jia L

Drug Design, Development and Therapy 2022, 16:2383-2393

Published Date: 26 July 2022

Icariin and Competing Endogenous RNA Network: A Potential Protective Strategy Against Contrast-Induced Acute Kidney Injury

Lin Y, Zhu G, Li X, Yu H, Luo Y, Lin J, Li R, Huang Z

Drug Design, Development and Therapy 2022, 16:2343-2363

Published Date: 23 July 2022

A Potent EGFR Inhibitor, N-Phenyl Pyrazoline Derivative Suppresses Aggressiveness and Cancer Stem Cell-Like Phenotype of Cervical Cancer Cells

Mustofa, Satriyo PB, Suma AAT, Waskitha SSW, Wahyuningsih TD, Sholikhah EN

Drug Design, Development and Therapy 2022, 16:2325-2339

Published Date: 20 July 2022

Magnesium Lithospermate B Protects Against Cisplatin-Induced Acute Kidney Injury via Alleviating Mitochondrial Dysfunction

Shen D, Guo M, Geng X, Yu J, Zhang Z, Lin J, Lin P, Ding X, Xu X

Drug Design, Development and Therapy 2022, 16:2293-2304

Published Date: 15 July 2022

Population Pharmacokinetic Modelling for Nifedipine to Evaluate the Effect of Parathyroid Hormone on CYP3A in Patients with Chronic Kidney Disease

Fu C, Pei Q, Liang W, Yang B, Li W, Liu J, Tan H, Guo C, Zhang H, Yang G

Drug Design, Development and Therapy 2022, 16:2261-2274

Published Date: 13 July 2022

Paeoniflorin Ameliorates BiPN by Reducing IL6 Levels and Regulating PARKIN-Mediated Mitochondrial Autophagy

Sun R, Liu J, Yu M, Xia M, Zhang Y, Sun X, Xu Y, Cui X

Drug Design, Development and Therapy 2022, 16:2241-2259

Published Date: 13 July 2022

Effects of Dexmedetomidine Administered Through Different Routes on Kidney Tissue in Rats with Spinal Cord Ischaemia–Reperfusion Injury

Şengel N, Köksal Z, Dursun AD, Kurtipek Ö, Sezen ŞC, Arslan M, Kavutçu M

Drug Design, Development and Therapy 2022, 16:2229-2239

Published Date: 13 July 2022

Effects of Super-Activated Platelet Lysate on Early Healing of Tooth Extraction Sockets in Rats

Guo X, Lu H, Liu C, Zhang Y, Bi L

Drug Design, Development and Therapy 2022, 16:2213-2227

Published Date: 13 July 2022

Recent Progress in the Development of Opaganib for the Treatment of Covid-19

Smith CD, Maines LW, Keller SN, Katz Ben-Yair V, Fathi R, Plasse TF, Levitt ML

Drug Design, Development and Therapy 2022, 16:2199-2211

Published Date: 12 July 2022

Combination Therapy of Ezetimibe and Rosuvastatin for Dyslipidemia: Current Insights

Chilbert MR, VanDuyn D, Salah S, Clark CM, Ma Q

Drug Design, Development and Therapy 2022, 16:2177-2186

Published Date: 7 July 2022

The Role of Dexmedetomidine in Tumor-Progressive Factors in the Perioperative Period and Cancer Recurrence: A Narrative Review

Cai Q, Liu G, Huang L, Guan Y, Wei H, Dou Z, Liu D, Hu Y, Gao M

Drug Design, Development and Therapy 2022, 16:2161-2175

Published Date: 6 July 2022

Orexin-A Reverse Bone Mass Loss Induced by Chronic Intermittent Hypoxia Through OX1R-Nrf2/HIF-1α Pathway

Gu H, Ru Y, Wang W, Cai G, Gu L, Ye J, Zhang WB, Wang L

Drug Design, Development and Therapy 2022, 16:2145-2160

Published Date: 5 July 2022

Palmatine Protects Against MSU-Induced Gouty Arthritis via Regulating the NF-κB/NLRP3 and Nrf2 Pathways

Cheng JJ, Ma XD, Ai GX, Yu QX, Chen XY, Yan F, Li YC, Xie JH, Su ZR, Xie QF

Drug Design, Development and Therapy 2022, 16:2119-2132

Published Date: 2 July 2022

Shikonin Could Be Used to Treat Tubal Pregnancy via Enhancing Ferroptosis Sensitivity

Lai Y, Zeng F, Chen Z, Feng M, Huang Y, Qiu P, Zeng L, Ke Y, Deng G, Gao J

Drug Design, Development and Therapy 2022, 16:2083-2099

Published Date: 1 July 2022

Pharmacological Aspects of Natural Quercetin in Rheumatoid Arthritis

Tang M, Zeng Y, Peng W, Xie X, Yang Y, Ji B, Li F

Drug Design, Development and Therapy 2022, 16:2043-2053

Published Date: 29 June 2022

Inhibition of Axitinib on Buspirone Metabolism in vitro and in vivo

Zhang BW, Pang NH, Xu RA, Qu GE, Tang CR

Drug Design, Development and Therapy 2022, 16:2031-2042

Published Date: 30 June 2022

Protective Effect of Hedyotis diffusa Willd. Ethanol Extract on Isoniazid-Induced Liver Injury in the Zebrafish Model

Wang X, Zhao J, Zhang R, Liu X, Ma C, Cao G, Wei Y, Yang P

Drug Design, Development and Therapy 2022, 16:1995-2015

Published Date: 27 June 2022

Nano Sized Hydroxyapatite-Polylactic Acid-Vancomycin in Alleviation of Chronic Osteomyelitis

Lv XF, Zhou DM, Sun XH, Zhao Z

Drug Design, Development and Therapy 2022, 16:1983-1993

Published Date: 27 June 2022

Switching from a Non-Protease inhibitor-Based Regimen To the Fixed Dose Combination of Darunavir/Cobicistat/Emtricitabine/Tenofovir Alafenamide in Clinical Practice

Ranzenigo M, Gianotti N, Galli L, Poli A, Mastrangelo A, Bruzzesi E, Chiurlo M, Nozza S, Bossolasco S, Spagnuolo V, Mancusi D, Termini R, Carini E, Lazzarin A, Castagna A

Drug Design, Development and Therapy 2022, 16:1975-1982

Published Date: 27 June 2022

Human Growth Hormone Fragment 176–191 Peptide Enhances the Toxicity of Doxorubicin-Loaded Chitosan Nanoparticles Against MCF-7 Breast Cancer Cells

Habibullah MM, Mohan S, Syed NK, Makeen HA, Jamal QMS, Alothaid H, Bantun F, Alhazmi A, Hakamy A, Kaabi YA, Samlan G, Lohani M, Thangavel N, Al-Kasim MA

Drug Design, Development and Therapy 2022, 16:1963-1974

Published Date: 27 June 2022

Dietary Supplement of Anoectochilus roxburghii (Wall.) Lindl. Polysaccharides Ameliorates Cognitive Dysfunction Induced by High Fat Diet via “Gut-Brain” Axis

Fu L, Zhu W, Tian D, Tang Y, Ye Y, Wei Q, Zhang C, Qiu W, Qin D, Yang X, Huang Y

Drug Design, Development and Therapy 2022, 16:1931-1945

Published Date: 20 June 2022

Comprehensive Analysis of Metabolic Changes in Male Mice Exposed to Sodium Valproate Based on GC-MS Analysis

Gao Y, Jiang D, Wang C, An G, Zhu L, Cui C

Drug Design, Development and Therapy 2022, 16:1915-1930

Published Date: 17 June 2022

Population Pharmacokinetics of Tigecycline: A Systematic Review

Zhou CC, Huang F, Zhang JM, Zhuang YG

Drug Design, Development and Therapy 2022, 16:1885-1896

Published Date: 17 June 2022

The Steady-State Comparative Bioavailability of Intramuscular Risperidone ISM and Oral Risperidone: An Open-Label, One-Sequence Study [Corrigendum]

Walling DP, Hassman HA, Anta L, Ochoa L, Ayani I, Martínez J, Gutierro I

Drug Design, Development and Therapy 2022, 16:1791-1792

Published Date: 13 June 2022

Effects of Simvastatin on the Metabolism of Vonoprazan in Rats Both in vitro and in vivo

Hong Y, Dai DP, Cai JP, Wang SH, Wang YR, Zhao FL, Zhou S, Zhou Q, Geng PW, Zhou YF, Xu X, Shi JH, Luo QF

Drug Design, Development and Therapy 2022, 16:1779-1789

Published Date: 9 June 2022

Anti-Hyperglycemic Agents in the Adjuvant Treatment of Sepsis: Improving Intestinal Barrier Function

Wang YF, Li JW, Wang DP, Jin K, Hui JJ, Xu HY

Drug Design, Development and Therapy 2022, 16:1697-1711

Published Date: 4 June 2022

THSD7B Mutation Induces Platinum Resistance in Small Cell Lung Cancer Patients

Yao Z, Lin A, Yi Y, Shen W, Zhang J, Luo P

Drug Design, Development and Therapy 2022, 16:1679-1695

Published Date: 3 June 2022

The Antithrombotic Effect of Recombinant Neorudin on Thrombi

Liu YB, Zhang L, Zhou XC, Zhou Y, Liu Y, Zheng C, Xu X, Geng PP, Hao CH, Zhao ZY, Wu CT, Jin JD

Drug Design, Development and Therapy 2022, 16:1667-1678

Published Date: 2 June 2022

Determination of the Cut-off Value for Imatinib Plasma Levels Linked to Occurrence of Bone Pain in CML Patients

Hamza MS, Shouman SA, Abdelfattah R, Moussa HS, Omran MM

Drug Design, Development and Therapy 2022, 16:1595-1604

Published Date: 30 May 2022

Novel 2-(5-Aryl-4,5-Dihydropyrazol-1-yl)thiazol-4-One as EGFR Inhibitors: Synthesis, Biological Assessment and Molecular Docking Insights

Al-Warhi T, El Kerdawy AM, Said MA, Albohy A, Elsayed ZM, Aljaeed N, Elkaeed EB, Eldehna WM, Abdel-Aziz HA, Abdelmoaz MA

Drug Design, Development and Therapy 2022, 16:1457-1471

Published Date: 16 May 2022

Silibinin Schiff Base Derivatives Counteract CCl4-Induced Acute Liver Injury by Enhancing Anti-Inflammatory and Antiapoptotic Bioactivities

Xu R, Qiu S, Zhang J, Liu X, Zhang L, Xing H, You M, Wang M, Lu Y, Zhang P, Zhu J

Drug Design, Development and Therapy 2022, 16:1441-1456

Published Date: 16 May 2022

Compatibility and Stability of Ten Commonly Used Clinical Drugs in Pediatric Electrolyte Supplements Injection

Shen H, Fu Y, Chen Y, Xia W, Jia ZJ, Yu Q, Zhang L, Han L

Drug Design, Development and Therapy 2022, 16:1433-1440

Published Date: 12 May 2022

RETRACTED ARTICLE: Preparation, in vitro and in vivo Evaluation of Thermosensitive in situ Gel Loaded with Ibuprofen-Solid Lipid Nanoparticles for Rectal Delivery

Huang CH, Hu PY, Wu QY, Xia MY, Zhang WL, Lei ZQ, Li DX, Zhang GS, Feng JF

Drug Design, Development and Therapy 2022, 16:1407-1431

Published Date: 12 May 2022

Gancao Xiexin Decoction Ameliorates Ulcerative Colitis in Mice via Modulating Gut Microbiota and Metabolites

Luo YT, Wu J, Zhu FY, Wu JQ, Wu P, Liu YC

Drug Design, Development and Therapy 2022, 16:1383-1405

Published Date: 9 May 2022

Pharmacokinetics and Safety of Single and Multiple Doses of Peficitinib (ASP015K) in Healthy Chinese Subjects

Gao X, He X, Oshima H, Miyatake D, Otsuka Y, Kato K, Cai C, Wojtkowski T, Song N, Kaneko Y, Shi A

Drug Design, Development and Therapy 2022, 16:1365-1381

Published Date: 9 May 2022

Knee Osteoarthritis Therapy: Recent Advances in Intra-Articular Drug Delivery Systems

Ma L, Zheng X, Lin R, Sun AR, Song J, Ye Z, Liang D, Zhang M, Tian J, Zhou X, Cui L, Liu Y, Liu Y

Drug Design, Development and Therapy 2022, 16:1311-1347

Published Date: 4 May 2022

Novel Liposomal Rolipram Formulation for Clinical Application to Reduce Emesis

Gobejishvili L, Rodriguez WE, Bauer P, Wang Y, Soni C, Lydic T, Barve S, McClain C, Maldonado C

Drug Design, Development and Therapy 2022, 16:1301-1309

Published Date: 3 May 2022

Isoliquiritigenin Ameliorates Ischemia-Induced Myocardial Injury via Modulating the Nrf2/HO-1 Pathway in Mice

Yao D, Shi B, Wang S, Bao L, Tan M, Shen H, Zhang Z, Pan X, Yang Y, Wu Y, Gong K

Drug Design, Development and Therapy 2022, 16:1273-1287

Published Date: 29 April 2022

The Emerging Potential of Parthenolide Nanoformulations in Tumor Therapy

An T, Yin H, Lu Y, Liu F

Drug Design, Development and Therapy 2022, 16:1255-1272

Published Date: 29 April 2022

Integrated Network Pharmacology and Metabolomics Analysis to Reveal the Potential Mechanism of Siwu Paste on Aplastic Anemia Induced by Chemotherapy Drugs

He D, Dan W, Du Q, Shen BB, Chen L, Fang LZ, Kuang JJ, Tang CY, Cai P, Yu R, Zhang SH, Huang JH

Drug Design, Development and Therapy 2022, 16:1231-1254

Published Date: 28 April 2022

Intrathecal Injection of Ropivacaine Reduces Cervical Resistance in Late-Pregnant Rats

Hu Y, Fan LJ, Jiang YM, Liu H, Yong H, Peng C

Drug Design, Development and Therapy 2022, 16:1183-1189

Published Date: 26 April 2022

Effect of Systemic Lidocaine on Postoperative Early Recovery Quality in Patients Undergoing Supratentorial Tumor Resection

Zhao K, Dong Y, Su G, Wang Y, Ji T, Wu N, Cui X, Li W, Yang Y, Chen X

Drug Design, Development and Therapy 2022, 16:1171-1181

Published Date: 22 April 2022

Carvacrol Alleviates Hyperuricemia-Induced Oxidative Stress and Inflammation by Modulating the NLRP3/NF-κB Pathwayt

Riaz M, Al Kury LT, Atzaz N, Alattar A, Alshaman R, Shah FA, Li S

Drug Design, Development and Therapy 2022, 16:1159-1170

Published Date: 22 April 2022

Analagesic and Anti-Inflammatory Potentials of a Less Ulcerogenic Thiadiazinethione Derivative in Animal Models: Biochemical and Histochemical Correlates

Rahman K, Ali G, Khan R, Khan I, Ali I, Mosa OF, Ahmed A, Ayaz M, Nawaz A, Murthy HCA

Drug Design, Development and Therapy 2022, 16:1143-1157

Published Date: 21 April 2022

Dezocine Has the Potential to Regulate the Clinical and Biological Features of Tumors

Hu X, Luo B, Qiu L, Chen S, Wu Q, Chen Q, Liu X, Ling C, Deng S, Yuan M, Hu P

Drug Design, Development and Therapy 2022, 16:1121-1129

Published Date: 20 April 2022

Design, Synthesis, and Biological Evaluation of 2-Anilino-4-Triazolpyrimidine Derivatives as CDK4/HDACs Inhibitors

Wang S, Han S, Cheng W, Miao R, Li S, Tian X, Kan Q

Drug Design, Development and Therapy 2022, 16:1083-1097

Published Date: 11 April 2022

Progress on SARS-CoV-2 3CLpro Inhibitors: Inspiration from SARS-CoV 3CLpro Peptidomimetics and Small-Molecule Anti-Inflammatory Compounds

Zhu J, Zhang H, Lin Q, Lyu J, Lu Lu, Chen H, Zhang X, Zhang Y, Chen K

Drug Design, Development and Therapy 2022, 16:1067-1082

Published Date: 8 April 2022

Synergistic Effect of Combined Sub-Tenon Triamcinolone and Intravitreal Anti-VEGF Therapy for Uveitic Macular Edema

Lin D, Hu J, Wu K, Feng K, Zhao X, Lu Q, Ren M, Cao J, Liu R, Dai M, Nan K, Wang Y

Drug Design, Development and Therapy 2022, 16:1055-1066

Published Date: 8 April 2022

Therapeutic Potential of Janus Kinase Inhibitors for the Management of Interstitial Lung Disease

Huo R, Guo Q, Hu J, Li N, Gao R, Mi L, Zhang Z, Liu H, Guo Z, Zhao H, Zhang L, Xu K

Drug Design, Development and Therapy 2022, 16:991-998

Published Date: 2 April 2022

Involvement of Huanglian Jiedu Decoction on Microglia with Abnormal Sphingolipid Metabolism in Alzheimer’s Disease

Qi YY, Heng X, Yao ZY, Qu SY, Ge PY, Zhao X, Ni S, Guo R, Yang NY, Zhang QC, Zhu HX

Drug Design, Development and Therapy 2022, 16:931-950

Published Date: 30 March 2022

Molecular Mechanism Underlying Effects of Wumeiwan on Steroid-Dependent Asthma: A Network Pharmacology, Molecular Docking, and Experimental Verification Study

Lyu M, Wang Y, Chen Q, Qin J, Hou D, Huang S, Shao D, Gong X, Huang G, Zhang S, Zhang Z, Cui H

Drug Design, Development and Therapy 2022, 16:909-929

Published Date: 30 March 2022

Design, Synthesis and Biological Evaluation of 1,4-Benzenesulfonamide Derivatives as Glyoxalase I Inhibitors

Audat SA, Al-Balas QA, Al-Oudat BA, Athamneh MJ, Bryant-Friedrich A

Drug Design, Development and Therapy 2022, 16:873-885

Published Date: 28 March 2022

Clotrimazole Inhibits HCC Migration and Invasion by Modulating the ERK-p65 Signaling Pathway

Liu X, Gao J, Sun Y, Zhang F, Guo W, Zhang S

Drug Design, Development and Therapy 2022, 16:863-871

Published Date: 29 March 2022

Antidepressant-Like Effect and Mechanism of Ginsenoside Rd on Rodent Models of Depression

Li Y, Wang ML, Zhang B, Fan XX, Tang Q, Yu X, Li LN, Fan AR, Chang HS, Zhang LZ

Drug Design, Development and Therapy 2022, 16:843-861

Published Date: 28 March 2022

Use of Antivirals in SARS-CoV-2 Infection. Critical Review of the Role of Remdesivir

Moreno S, Alcázar B, Dueñas C, González del Castillo J, Olalla J, Antela A

Drug Design, Development and Therapy 2022, 16:827-841

Published Date: 25 March 2022

Co-Administration with Voriconazole Doubles the Exposure of Ruxolitinib in Patients with Hematological Malignancies

Zhao Y, Chen P, Dou L, Li F, Li M, Xu L, Chen J, Jia M, Huang S, Wang N, Luan S, Yang J, Bai N, Liu D

Drug Design, Development and Therapy 2022, 16:817-825

Published Date: 25 March 2022

cRGD Urokinase Liposomes for Thrombolysis in Rat Model of Acute Pulmonary Microthromboembolism

Liang C, Huang T, Zhang X, Rao H, Jin Z, Pan X, Li J, Mo Y, Cai Y, Wu J

Drug Design, Development and Therapy 2022, 16:801-816

Published Date: 25 March 2022

Yishen Qingli Heluo Granule in the Treatment of Chronic Kidney Disease: Network Pharmacology Analysis and Experimental Validation

Sun X, Huang Y, Zhu S, Yan J, Gan K, Xu Z, Wang S, Kang X, Zhang J, Sun W

Drug Design, Development and Therapy 2022, 16:769-787

Published Date: 24 March 2022

Clinical Characteristics and Risk Factors of Lung Injury Induced by Nab-Paclitaxel

Yoshioka K, Abe M, Shiko Y, Koshikawa K, Kawasaki Y, Iwasawa S, Terada J, Tsushima K, Tatsumi K, Suzuki T

Drug Design, Development and Therapy 2022, 16:759-767

Published Date: 22 March 2022

Comparing Efficacy of Different Analgesic Modalities in Patients Undergoing Total Knee Arthroplasty [Response To Letter]

Xiao R, Liu LF, Luo YR, Liu C, Jin XB, Zhou W, Xu GH

Drug Design, Development and Therapy 2022, 16:737-738

Published Date: 18 March 2022

A Systematic Review of the Global Intervention for SARS-CoV-2 Combating: From Drugs Repurposing to Molnupiravir Approval

Ashour NA, Abo Elmaaty A, Sarhan AA, Elkaeed EB, Moussa AM, Erfan IA, Al-Karmalawy AA

Drug Design, Development and Therapy 2022, 16:685-715

Published Date: 15 March 2022

The Astragaloside IV Derivative LS-102 Ameliorates Obesity-Related Nephropathy

Li Z, Yang W, Yang Y, Wu J, Luo P, Liu Y

Drug Design, Development and Therapy 2022, 16:647-664

Published Date: 14 March 2022

Platelet Rich Plasma and Its Use in Hair Regrowth: A Review

Paichitrojjana A, Paichitrojjana A

Drug Design, Development and Therapy 2022, 16:635-645

Published Date: 10 March 2022

Determination of the Dose-Response Relationship of Epidural Dexmedetomidine Combined with Ropivacaine for Labor Analgesia

Ni JX, Feng JL, Yao SJ, Ni LF, Song SB, Song CZ, Qian XW, Mei Z, Yu J

Drug Design, Development and Therapy 2022, 16:609-618

Published Date: 6 March 2022

New Series of VEGFR-2 Inhibitors and Apoptosis Enhancers: Design, Synthesis and Biological Evaluation

Abdallah AE, Mabrouk RR, Elnagar MR, Farrag AM, Kalaba MH, Sharaf MH, El-Fakharany EM, Bakhotmah DA, Elkaeed EB, Al Ward MMS

Drug Design, Development and Therapy 2022, 16:587-607

Published Date: 3 March 2022

Alleviating Aspirin-Induced Gastric Injury by Binding Aspirin to β-Lactoglobulin

Chen J, Gong M, Huang Z, Wang F, Wang Y, Hu Z, Zeng Z, Wang Y

Drug Design, Development and Therapy 2022, 16:571-586

Published Date: 1 March 2022

α-Mangostin Treats Early-Stage Adjuvant-Induced Arthritis of Rat by Regulating the CAP-SIRT1 Pathway in Macrophages

Chen WG, Zhang SS, Pan S, Wang ZF, Xu JY, Sheng XH, Yin Q, Wu YJ

Drug Design, Development and Therapy 2022, 16:509-520

Published Date: 27 February 2022

Safety, Pharmacokinetics and Pharmacodynamics of the Selective Glucocorticoid Receptor Modulator Velsecorat (AZD7594) Following Inhalation in Healthy Volunteers

Prothon S, Aurivillius M, Tehler U, Eriksson UG, Aggarwal A, Chen Y

Drug Design, Development and Therapy 2022, 16:485-497

Published Date: 23 February 2022

Noncanonical Wnt5a Signaling Suppresses Hippo/TAZ-Mediated Osteogenesis Partly Through the Canonical Wnt Pathway in SCAPs

Fu Y, Ma D, Fan F, Sun T, Han R, Yang Y, Zhang J

Drug Design, Development and Therapy 2022, 16:469-483

Published Date: 22 February 2022

Network Pharmacology and Molecular Docking Study of the Chinese Miao Medicine Sidaxue in the Treatment of Rheumatoid Arthritis

Wu N, Yuan T, Yin Z, Yuan X, Sun J, Wu Z, Zhang Q, Redshaw C, Yang S, Dai X

Drug Design, Development and Therapy 2022, 16:435-466

Published Date: 19 February 2022

Spray with Nitric Oxide Donor Accelerates Wound Healing: Potential Off-the-Shelf Solution for Therapy?

Igrunkova A, Fayzullin A, Churbanov S, Shevchenko P, Serejnikova N, Chepelova N, Pahomov D, Blinova E, Mikaelyan K, Zaborova V, Gurevich K, Urakov A, Vanin A, Timashev P, Shekhter A

Drug Design, Development and Therapy 2022, 16:349-362

Published Date: 16 February 2022

Emodin-Induced Autophagy Against Cell Apoptosis Through the PI3K/AKT/mTOR Pathway in Human Hepatocytes [Corrigendum]

Zheng X, Yang S, Zhang R, Wang S, Li G, Zhou S

Drug Design, Development and Therapy 2022, 16:345-347

Published Date: 16 February 2022

Uncovering the Potential Mechanisms of Coptis chinensis Franch. for Serious Mental Illness by Network Pharmacology and Pharmacology-Based Analysis

Qi Y, Ni S, Heng X, Qu S, Ge P, Zhao X, Yao Z, Guo R, Yang N, Zhang Q, Zhu H

Drug Design, Development and Therapy 2022, 16:325-342

Published Date: 9 February 2022

The Role of Progesterone Receptors in Breast Cancer

Li Z, Wei H, Li S, Wu P, Mao X

Drug Design, Development and Therapy 2022, 16:305-314

Published Date: 26 January 2022

Feasibility of Catalpol Intranasal Administration and Its Protective Effect on Acute Cerebral Ischemia in Rats via Anti-Oxidative and Anti-Apoptotic Mechanisms

Wang J, Zhang Y, Zhang M, Sun S, Zhong Y, Han L, Xu Y, Wan D, Zhang J, Zhu H

Drug Design, Development and Therapy 2022, 16:279-296

Published Date: 25 January 2022

Inhibition of JNK Phosphorylation by Curcumin Analog C66 Protects LPS-Induced Acute Lung Injury [Corrigendum]

Xiao Z, Xu F, Zhu X, Bai B, Guo L, Liang G, Shan X, Zhang Y, Zhao Y, Zhang B

Drug Design, Development and Therapy 2022, 16:249-250

Published Date: 19 January 2022

Advances in Engineered Three-Dimensional (3D) Body Articulation Unit Models

Chen Y, Wang Y, Luo SC, Zheng X, Kankala RK, Wang SB, Chen AZ

Drug Design, Development and Therapy 2022, 16:213-235

Published Date: 18 January 2022

Clinical Utility of Elosulfase Alfa in the Treatment of Morquio A Syndrome

Lee CL, Chuang CK, Chiu HC, Tu RY, Lo YT, Chang YH, Lin SP, Lin HY

Drug Design, Development and Therapy 2022, 16:143-154

Published Date: 10 January 2022

Berbamine Suppresses the Growth of Gastric Cancer Cells by Inactivating the BRD4/c-MYC Signaling Pathway

Li H, Luo K, Yang Z, Chen M, Yang X, Wang J, Ying Y, Wu D, Wang Q

Drug Design, Development and Therapy 2022, 16:129-141

Published Date: 11 January 2022

Intramuscular Corticosteroid Therapy in the Treatment of Alopecia Areata: A Time-to-Event Analysis

Chanprapaph K, Pomsoong C, Kositkuljorn C, Suchonwanit P

Drug Design, Development and Therapy 2022, 16:107-116

Published Date: 7 January 2022

Inhibition of CXCR4 in Spinal Cord and DRG with AMD3100 Attenuates Colon-Bladder Cross-Organ Sensitization

Zhang H, Dong X, Yang Z, Zhao J, Lu Q, Zhu J, Li L, Yi S, Xu J

Drug Design, Development and Therapy 2022, 16:67-81

Published Date: 6 January 2022

Promising Natural Products in New Drug Design, Development, and Therapy for Skin Disorders: An Overview of Scientific Evidence and Understanding Their Mechanism of Action

Mohd Zaid NA, Sekar M, Bonam SR, Gan SH, Lum PT, Begum MY, Mat Rani NNI, Vaijanathappa J, Wu YS, Subramaniyan V, Fuloria NK, Fuloria S

Drug Design, Development and Therapy 2022, 16:23-66

Published Date: 6 January 2022

Fatostatin in Combination with Tamoxifen Induces Synergistic Inhibition in ER-Positive Breast Cancer [Corrigendum]

Liu Y, Zhang N, Zhang H, Wang L, Duan Y, Wang X, Chen T, Liang Y, Li Y, Song X, Li C, Han D, Chen B, Zhao W, Yang Q

Drug Design, Development and Therapy 2022, 16:1-2

Published Date: 5 January 2022