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Drug Design, Development and Therapy


Archive: Volume 15, 2021

Dynamics of Endocytosis and Degradation of Antibody-Drug Conjugate T-DM1 in HER2 Positive Cancer Cells

Liang K, Mei S, Gao X, Peng S, Zhan J

Drug Design, Development and Therapy 2021, 15:5135-5150

Published Date: 24 December 2021

Downregulation of IRF2 Alleviates Sepsis-Related Acute Kidney Injury in vitro and in vivo

Zhang Y, Zhang Y, Yang A, Xia F

Drug Design, Development and Therapy 2021, 15:5123-5132

Published Date: 22 December 2021

Establishment of Sunitinib-Resistant Xenograft Model of Renal Cell Carcinoma and the Identification of Drug-Resistant Hub Genes and Pathways

Xie Y, Shangguan W, Chen Z, Zheng Z, Chen Y, Zhong Q, Zhang Y, Yang J, Zhu D, Xie W

Drug Design, Development and Therapy 2021, 15:5061-5074

Published Date: 16 December 2021

Drug Repurposing: Deferasirox Inhibits the Anti-Apoptotic Activity of Mcl-1

Bourafai-Aziez A, Benabderrahmane M, Paysant H, Weiswald LB, Poulain L, Carlier L, Ravault D, Jouanne M, Coadou G, Oulyadi H, Voisin-Chiret AS, Sopková-de Oliveira Santos J, Sebban M

Drug Design, Development and Therapy 2021, 15:5035-5059

Published Date: 15 December 2021

(Rose Bengal)/(Eosin Yellow)-Gold-Polypyrrole Hybrids: A Design for Dual Photo-Active Nano-System with Ultra-High Loading Capacity

El-Kholy AI, Abdel Fadeel D, Nasr M, Fadel M, El-Sherbiny I

Drug Design, Development and Therapy 2021, 15:5011-5023

Published Date: 14 December 2021

Bio-Guided Isolation of Two New Hypoglycemic Triterpenoid Saponins from Polygonum capitatum

Huang D, Du Z, Chen Y, Dong Z, Wang X, Li M, Zhang F, Chen W, Sun L

Drug Design, Development and Therapy 2021, 15:5001-5010

Published Date: 14 December 2021

Cell-Penetrating Peptide-Modified Graphene Oxide Nanoparticles Loaded with Rictor siRNA for the Treatment of Triple-Negative Breast Cancer

Yang YY, Zhang W, Liu H, Jiang JJ, Wang WJ, Jia ZY

Drug Design, Development and Therapy 2021, 15:4961-4972

Published Date: 10 December 2021

Effects of Dezocine and Sufentanil on Th1/Th2 Balance in Breast Cancer Patients Undergoing Surgery

Hu X, Luo B, Wu Q, Chen Q, Lu P, Huang J, Liang X, Ling C, Li Y

Drug Design, Development and Therapy 2021, 15:4925-4938

Published Date: 2 December 2021

Network Pharmacology and Experimental Validation to Reveal the Pharmacological Mechanisms of Liuwei Dihuang Decoction Against Intervertebral Disc Degeneration

Zhang H, Yao S, Zhang Z, Zhou C, Fu F, Bian Y, Luo H, Li Y, Yan S, Ge Y, Chen Y, Zhan K, Ge Y, Chen Z, Yue M, Li X, Du W, Jin H, Tong P, Ruan H, Wu C

Drug Design, Development and Therapy 2021, 15:4911-4924

Published Date: 2 December 2021

Protective Effects of Mogroside V on Oxidative Stress Induced by H2O2 in Skin Fibroblasts

Mo Q, Fu H, Zhao D, Zhang J, Wang C, Wang D, Li M

Drug Design, Development and Therapy 2021, 15:4901-4909

Published Date: 1 December 2021

Ventilagolin Suppresses Migration, Invasion and Epithelial-Mesenchymal Transition of Hepatocellular Carcinoma Cells by Downregulating Pim-1

Liu Y, Cheng DH, Lai KD, Su H, Lu GS, Wang L, Lv JH

Drug Design, Development and Therapy 2021, 15:4885-4899

Published Date: 1 December 2021

Ruxolitinib for Treatment of Steroid-Refractory Graft-versus-Host Disease: Real-World Data from Chinese Patients

Wei C, Zhang X, Liang D, Yang J, Du J, Yue C, Deng L

Drug Design, Development and Therapy 2021, 15:4875-4883

Published Date: 30 November 2021

The Pharmacokinetic Effect of Itraconazole and Voriconazole on Ripretinib in Beagle Dogs by UPLC-MS/MS Technique

Wang H, Zhou C, Su Y, Gou K, Geng X, Qiu X

Drug Design, Development and Therapy 2021, 15:4865-4873

Published Date: 30 November 2021

Methylcobalamin Protects Melanocytes from H2O2-Induced Oxidative Stress by Activating the Nrf2/HO-1 Pathway

An R, Li D, Dong Y, She Q, Zhou T, Nie X, Pan R, Deng Y

Drug Design, Development and Therapy 2021, 15:4837-4848

Published Date: 30 November 2021

UPLC–MS/MS and Network Pharmacology-Based Analysis of Bioactive Anti-Depression Compounds in Betel Nut

Yang Y, Huang H, Cui Z, Chu J, Du G

Drug Design, Development and Therapy 2021, 15:4827-4836

Published Date: 30 November 2021

Oroxin B Attenuates Ovariectomy-Induced Bone Loss by Suppressing Osteoclast Formation and Activity

Huang JM, Wang CZ, Lu SY, Wang Z, Yan ZQ

Drug Design, Development and Therapy 2021, 15:4811-4825

Published Date: 30 November 2021

Berberine Influences the Survival of Fat Grafting by Inhibiting Autophagy and Apoptosis of Human Adipose Derived Mesenchymal Stem Cells

Pang H, Zhou Y, Wang J, Wu H, Liu X, Gao F, Xiao Z

Drug Design, Development and Therapy 2021, 15:4795-4809

Published Date: 30 November 2021

Toxicological Evaluation of a Probiotic-Based Delivery System for P8 Protein as an Anti-Colorectal Cancer Drug

An BC, Yoon YS, Park HJ, Park S, Kim TY, Ahn JY, Kwon D, Choi O, Heo JY, Ryu Y, Kim JH, Eom H, Chung MJ

Drug Design, Development and Therapy 2021, 15:4761-4793

Published Date: 27 November 2021

Hearing Protection Outcomes of Analog Electrode Arrays Coated with Different Drug-Eluting Polymer Films Implanted into Guinea Pig Cochleae [Corrigendum]

Huang Y, Yu H, Liang M, Hou S, Chen JM, Zhang F, Sun X, Jia H, Yang J

Drug Design, Development and Therapy 2021, 15:4759-4760

Published Date: 24 November 2021

Inhibition of Lipopolysaccharide-Induced Inflammatory Bone Loss by Saikosaponin D is Associated with Regulation of the RANKL/RANK Pathway

Wu X, Zhao K, Fang X, Lu F, Zhang W, Song X, Chen L, Sun J, Chen H

Drug Design, Development and Therapy 2021, 15:4741-4757

Published Date: 23 November 2021

Clinical Effect of Doxycycline Combined with Compound Sulfamethoxazole and Rifampicin in the Treatment of Brucellosis Spondylitis

Yang XM, Jia YL, Zhang Y, Zhang PN, Yao Y, Yin YL, Tian Y

Drug Design, Development and Therapy 2021, 15:4733-4740

Published Date: 23 November 2021

Therapeutic Effects and Safe Uses of Plant-Derived Polyphenolic Compounds in Cardiovascular Diseases: A Review

Alotaibi BS, Ijaz M, Buabeid M, Kharaba ZJ, Yaseen HS, Murtaza G

Drug Design, Development and Therapy 2021, 15:4713-4732

Published Date: 20 November 2021

Activation of GPR18 by Resolvin D2 Relieves Pain and Improves Bladder Function in Cyclophosphamide-Induced Cystitis Through Inhibiting TRPV1

Lu Q, Yang Y, Zhang H, Chen C, Zhao J, Yang Z, Fan Y, Li L, Feng H, Zhu J, Yi S

Drug Design, Development and Therapy 2021, 15:4687-4699

Published Date: 15 November 2021

A Retrospective Cohort Study Evaluates Clinical Value of Anlotinib in Persistent, Metastatic, or Recurrent Cervical Cancer After Failure of First-Line Therapy

Yang H, Sun S, Mei Z, Xiang Q, Yang C, Chen M, Xie C, Zhou Y, Qiu H

Drug Design, Development and Therapy 2021, 15:4665-4674

Published Date: 16 November 2021

Transdermal Delivery of Telmisartan: Formulation, in vitro, ex vivo, Iontophoretic Permeation Enhancement and Comparative Pharmacokinetic Study in Rats

Teaima M, Abdelmonem R, Adel YA, El-Nabarawi MA, El-Nawawy TM

Drug Design, Development and Therapy 2021, 15:4603-4614

Published Date: 10 November 2021

Prunella vulgaris L. Attenuates Experimental Autoimmune Thyroiditis by Inhibiting HMGB1/TLR9 Signaling

Guo Q, Qu H, Zhang H, Zhong X

Drug Design, Development and Therapy 2021, 15:4559-4574

Published Date: 4 November 2021

Chemistry, Biosynthesis, Physicochemical and Biological Properties of Rubiadin: A Promising Natural Anthraquinone for New Drug Discovery and Development

Watroly MN, Sekar M, Fuloria S, Gan SH, Jeyabalan S, Wu YS, Subramaniyan V, Sathasivam KV, Ravi S, Mat Rani NNI, Lum PT, Vaijanathappa J, Meenakshi DU, Mani S, Fuloria NK

Drug Design, Development and Therapy 2021, 15:4527-4549

Published Date: 3 November 2021

Anti-Inflammatory Effects of Curcumin in the Inflammatory Diseases: Status, Limitations and Countermeasures

Peng Y, Ao M, Dong B, Jiang Y, Yu L, Chen Z, Hu C, Xu R

Drug Design, Development and Therapy 2021, 15:4503-4525

Published Date: 2 November 2021

Artemisinin Improves Acetylcholine-Induced Vasodilatation in Rats with Primary Hypertension

Liu X, Wang X, Pan Y, Zhao L, Sun S, Luo A, Bao C, Tang H, Han Y

Drug Design, Development and Therapy 2021, 15:4489-4502

Published Date: 2 November 2021

Enhancement of Cancer Chemotherapeutic Efficacy via Bone-Targeted Drug Delivery Carrier in Bone Metastases

Xue X, Yu J, Lu F, Jiang H, Wang X

Drug Design, Development and Therapy 2021, 15:4455-4468

Published Date: 28 October 2021

An Overview on the Potential Roles of EGCG in the Treatment of COVID-19 Infection

Bimonte S, Forte CA, Cuomo M, Esposito G, Cascella M, Cuomo A

Drug Design, Development and Therapy 2021, 15:4447-4454

Published Date: 28 October 2021

The Effects of Primary Unconjugated Bile Acids on Nanoencapsulated Pharmaceutical Formulation of Hydrophilic Drugs: Pharmacological Implications

Mooranian A, Foster T, Ionescu CM, Carey L, Walker D, Jones M, Wagle SR, Kovacevic B, Chester J, Johnstone E, Kuthubutheen J, Brown D, Atlas MD, Mikov M, Al-Salami H

Drug Design, Development and Therapy 2021, 15:4423-4434

Published Date: 23 October 2021

Mechanism of Yinqin Oral Liquid in the Treatment of Chronic Pharyngitis Based on Network Pharmacology

Ji S, Xu F, Zhu R, Wang C, Guo D, Jiang Y

Drug Design, Development and Therapy 2021, 15:4413-4421

Published Date: 20 October 2021

Unravelling the Protective Effects of Emodin Against Cyclophosphamide Induced Gonadotoxicity in Male Wistar Rats

Wang Y, Zou Z, Jaisi A, Olatunji OJ

Drug Design, Development and Therapy 2021, 15:4403-4411

Published Date: 19 October 2021

The Steady-State Comparative Bioavailability of Intramuscular Risperidone ISM and Oral Risperidone: An Open-Label, One-Sequence Study

Walling DP, Hassman HA, Anta L, Ochoa L, Ayani I, Martínez J, Gutierro I

Drug Design, Development and Therapy 2021, 15:4371-4382

Published Date: 15 October 2021

Translational Regulation in Hepatocellular Carcinogenesis

Bracic Tomazic S, Schatz C, Haybaeck J

Drug Design, Development and Therapy 2021, 15:4359-4369

Published Date: 14 October 2021

The Expanding Role of Pyridine and Dihydropyridine Scaffolds in Drug Design

Ling Y, Hao ZY, Liang D, Zhang CL, Liu YF, Wang Y

Drug Design, Development and Therapy 2021, 15:4289-4338

Published Date: 13 October 2021

Triptolide is a Promising Therapeutic Approach in Treating Thyroid Cancer Based on in silico and in vitro Experiment

Wang F, An SJ, Yin Y, Li JJ, Sun CH, Lan J, Zhao WJ, Li CQ

Drug Design, Development and Therapy 2021, 15:4275-4287

Published Date: 11 October 2021

The Therapeutic Effects of Curcumin in Early Septic Acute Kidney Injury: An Experimental Study

Wang S, Zhao P, Zhang Y, Zhu L, Zhu J, Luo Y, Li Q

Drug Design, Development and Therapy 2021, 15:4243-4255

Published Date: 7 October 2021

Saroglitazar – A Potential Therapeutic Option in Treating NASH? [Letter]

Shuja SH, Eqbal F, Rehman H

Drug Design, Development and Therapy 2021, 15:4227-4228

Published Date: 8 October 2021

Development and Characterization of Ulvan Polysaccharides-Based Hydrogel Films for Potential Wound Dressing Applications

Sulastri E, Zubair MS, Lesmana R, Mohammed AFA, Wathoni N

Drug Design, Development and Therapy 2021, 15:4213-4226

Published Date: 5 October 2021

Novel Anti-Tubulin Compounds from Trigonella foenum-graecum Seeds; Insights into In-vitro and Molecular Docking Studies

Alghamdi SS, Suliman RS, Alsaeed AS, Almutairi KK, Aljammaz NA, Altolayyan A, Ali R, Alhallaj A

Drug Design, Development and Therapy 2021, 15:4195-4211

Published Date: 5 October 2021

Synthesis of Novel Pinocembrin Amino Acid Derivatives and Their Antiaging Effect on Caenorhabditis elegans via the Modulating DAF-16/FOXO

Wang W, Feng X, Du Y, Liu C, Pang X, Jiang K, Wang X, Liu Y

Drug Design, Development and Therapy 2021, 15:4177-4193

Published Date: 5 October 2021

Development of an UPLC-MS/MS Method for the Quantitative Analysis of Upadacitinib in Beagle Dog Plasma and Pharmacokinetics Study

Wang MJ, Zhao YH, Fan C, Wang YJ, Wang XQ, Qiu XJ, Shen RL

Drug Design, Development and Therapy 2021, 15:4167-4175

Published Date: 2 October 2021

The Role of Pretreatment 18F-FDG PET/CT for Early Prediction of Neoadjuvant Chemotherapy Response in Patients with Locoregionally Advanced Nasopharyngeal Carcinoma

Yao J, Wang Y, Lin Y, Yang Y, Wan J, Gong X, Zhang F, Zhang W, Marks T, Wang S, Jin H, Shan H

Drug Design, Development and Therapy 2021, 15:4157-4166

Published Date: 1 October 2021

Transcriptome-Based Analysis Reveals Therapeutic Effects of Resveratrol on Endometriosis in aRat Model

Wang C, Chen Z, Zhao X, Lin C, Hong S, Lou Y, Shi X, Zhao M, Yang X, Guan MX, Xi Y

Drug Design, Development and Therapy 2021, 15:4141-4155

Published Date: 29 September 2021

Orally Deliverable Dual-Targeted Pellets for the Synergistic Treatment of Ulcerative Colitis

Tang X, Yang M, Gu Y, Jiang L, Du Y, Liu J

Drug Design, Development and Therapy 2021, 15:4105-4123

Published Date: 29 September 2021

Topical Lidocaine for Chronic Pain Treatment

Voute M, Morel V, Pickering G

Drug Design, Development and Therapy 2021, 15:4091-4103

Published Date: 29 September 2021

Evolution of Drug Delivery Systems for Recurrent Aphthous Stomatitis

Suharyani I, Fouad Abdelwahab Mohammed A, Muchtaridi M, Wathoni N, Abdassah M

Drug Design, Development and Therapy 2021, 15:4071-4089

Published Date: 27 September 2021

Synergistic Dose Permutation of Isolated Alkaloid and Sterol for Anticancer Effect on Young Swiss Albino Mice

Aljarba NH, Ali H, Alkahtani S

Drug Design, Development and Therapy 2021, 15:4043-4052

Published Date: 23 September 2021

Antioxidant, Anti-Aging and Organ Protective Effects of Total Saponins from Aralia taibaiensis

Li H, Zhai B, Sun J, Fan Y, Zou J, Cheng J, Zhang X, Shi Y, Guo D

Drug Design, Development and Therapy 2021, 15:4025-4042

Published Date: 23 September 2021

A Network Pharmacology Study on the Molecular Mechanism of Protocatechualdehyde in the Treatment of Diabetic Cataract

Cheng X, Song Z, Wang X, Xu S, Dong L, Bai J, Li G, Zhang C

Drug Design, Development and Therapy 2021, 15:4011-4023

Published Date: 23 September 2021

Non-Alcoholic Steatohepatitis (NASH) – A Review of a Crowded Clinical Landscape, Driven by a Complex Disease

Fraile JM, Palliyil S, Barelle C, Porter AJ, Kovaleva M

Drug Design, Development and Therapy 2021, 15:3997-4009

Published Date: 22 September 2021

Selection of DNA Aptamers Recognizing EpCAM-Positive Prostate Cancer by Cell-SELEX for in vitro and in vivo MR Imaging

Zhong J, Ding J, Deng L, Xiang Y, Liu D, Zhang Y, Chen X, Yang Q

Drug Design, Development and Therapy 2021, 15:3985-3996

Published Date: 21 September 2021

Stability of Amoxicillin and Clavulanic Acid in Separate Containers for Administration via a Y-Site

Fawaz S, Merzouk M, Barton S, Nabhani-Gebara S

Drug Design, Development and Therapy 2021, 15:3979-3984

Published Date: 21 September 2021

Ketamine Induces Ferroptosis of Liver Cancer Cells by Targeting lncRNA PVT1/miR-214-3p/GPX4

He GN, Bao NR, Wang S, Xi M, Zhang TH, Chen FS

Drug Design, Development and Therapy 2021, 15:3965-3978

Published Date: 18 September 2021

LC–MS/MS Estimation of Rociletinib Levels in Human Liver Microsomes: Application to Metabolic Stability Estimation

Attwa MW, Abdelhameed AS, Kadi AA

Drug Design, Development and Therapy 2021, 15:3915-3925

Published Date: 15 September 2021

The Anticancer Potential of Maslinic Acid and Its Derivatives: A Review

Yu L, Xie X, Cao X, Chen J, Chen G, Chen Y, Li G, Qin J, Peng F, Peng C

Drug Design, Development and Therapy 2021, 15:3863-3879

Published Date: 9 September 2021

In vitro Comparison of Pancreatic Enzyme Preparations Available in the Indian Market

Shrikhande SV, Prasad VGM, Domínguez-Muñoz JE, Weigl KE, Sarda KD

Drug Design, Development and Therapy 2021, 15:3835-3843

Published Date: 7 September 2021

Integrating Network Pharmacology and Experimental Verification to Explore the Mechanism of Effect of Zuojin Pills in Pancreatic Cancer Treatment

Wang K, Miao X, Kong F, Huang S, Mo J, Jin C, Zheng Y

Drug Design, Development and Therapy 2021, 15:3749-3764

Published Date: 4 September 2021

The Legislative Approach and System Improvement of China’s Compulsory Licensing for Drug Patents

Cao Z, Chen Y, Jiang W, Li W

Drug Design, Development and Therapy 2021, 15:3717-3731

Published Date: 1 September 2021

Retrospective Study of the Effects of Zoledronic Acid on Muscle Mass in Osteoporosis Patients

Huang CF, Shiao MS, Mao TY

Drug Design, Development and Therapy 2021, 15:3711-3715

Published Date: 27 August 2021

Puerarin Alleviates UUO-Induced Inflammation and Fibrosis by Regulating the NF-κB P65/STAT3 and TGFβ1/Smads Signaling Pathways

Wang J, Ge S, Wang Y, Liu Y, Qiu L, Li J, Huang X, Sun L

Drug Design, Development and Therapy 2021, 15:3697-3708

Published Date: 24 August 2021

Effects of Avitinib on CYP450 Enzyme Activity in vitro and in vivo in Rats

Shi Y, Meng D, Wang S, Geng P, Xu T, Zhou Q, Zhou Y, Li W, Chen X

Drug Design, Development and Therapy 2021, 15:3661-3673

Published Date: 21 August 2021

Icariin, an Up-and-Coming Bioactive Compound Against Neurological Diseases: Network Pharmacology-Based Study and Literature Review

Wang S, Ma J, Zeng Y, Zhou G, Wang Y, Zhou W, Sun X, Wu M

Drug Design, Development and Therapy 2021, 15:3619-3641

Published Date: 20 August 2021

Bi-aryl Analogues of Salicylic Acids: Design, Synthesis and SAR Study to Ameliorate Endoplasmic Reticulum Stress

Kim YE, Kim DH, Choi A, Jang S, Jeong K, Kim YM, Nam TG

Drug Design, Development and Therapy 2021, 15:3593-3604

Published Date: 17 August 2021

Gene Therapy for Rdh12-Associated Retinal Diseases Helps to Delay Retinal Degeneration and Vision Loss

Bian J, Chen H, Sun J, Cao Y, An J, Pan Q, Qi M

Drug Design, Development and Therapy 2021, 15:3581-3591

Published Date: 17 August 2021

The Clinical Efficacy of Three Different Follicle-Stimulating Hormones for Follicle Growth and Development in Long-Protocol Controlled Ovarian Hyperstimulation Treatment

Zhang XQ, Zhang LJ, Zhu XL, Xu H, Luo YQ, Yao L, Huang QW, Nong YQ, Liu WJ, Liu FH

Drug Design, Development and Therapy 2021, 15:3573-3580

Published Date: 16 August 2021

Prompt Agalsidase Alfa Therapy Initiation is Associated with Improved Renal and Cardiovascular Outcomes in a Fabry Outcome Survey Analysis

Hughes D, Linhart A, Gurevich A, Kalampoki V, Jazukeviciene D, Feriozzi S

Drug Design, Development and Therapy 2021, 15:3561-3572

Published Date: 16 August 2021

The Synergistic Effect of Ginkgo biloba Extract 50 and Aspirin Against Platelet Aggregation

Ke J, Li MT, Huo YJ, Cheng YQ, Guo SF, Wu Y, Zhang L, Ma J, Liu AJ, Han Y

Drug Design, Development and Therapy 2021, 15:3543-3560

Published Date: 14 August 2021

Effectiveness and Anticancer Activity of a Novel Phenolic Compound from Garcinia porrecta Against the MCF-7 Breast Cancer Cell Line in vitro and in silico

Darwati D, Safitri AN, Ambardhani N, Mayanti T, Nurlelasari N, Kurnia D

Drug Design, Development and Therapy 2021, 15:3523-3533

Published Date: 12 August 2021

Quercetin Prevents Oxidative Stress-Induced Injury of Periodontal Ligament Cells and Alveolar Bone Loss in Periodontitis

Wei Y, Fu J, Wu W, Ma P, Ren L, Yi Z, Wu J

Drug Design, Development and Therapy 2021, 15:3509-3522

Published Date: 12 August 2021

The Reproductive Toxicity of Monosodium Glutamate by Damaging GnRH Neurons Cannot Be Relieved Spontaneously Over Time

Wang CX, Zhang Y, Li QF, Sun HL, Chong HL, Jiang JX, Li QC

Drug Design, Development and Therapy 2021, 15:3499-3508

Published Date: 12 August 2021

Establishment of Prognostic Nomograms for Predicting the Survival of HR-Positive, HER2-Negative Metastatic Breast Cancer Patients Treated with Everolimus

Duan F, Song C, Ma Y, Jiang K, Xu F, Bi X, Huang J, Hong R, Huang Z, Lu Q, Yuan Z, Wang S, Xia W

Drug Design, Development and Therapy 2021, 15:3463-3473

Published Date: 10 August 2021

Ecust004 Suppresses Breast Cancer Cell Growth, Invasion, and Migration via EMT Regulation

Liu Z, Huang L, Sun L, Nie H, Liang Y, Huang J, Wu F, Hu X

Drug Design, Development and Therapy 2021, 15:3451-3461

Published Date: 10 August 2021

Hearing Protection Outcomes of Analog Electrode Arrays Coated with Different Drug-Eluting Polymer Films Implanted into Guinea Pig Cochleae

Huang Y, Yu H, Liang M, Hou S, Chen JM, Zhang F, Sun X, Jia H, Yang J

Drug Design, Development and Therapy 2021, 15:3443-3450

Published Date: 11 August 2021

Network Pharmacology and Experimental Evidence: PI3K/AKT Signaling Pathway is Involved in the Antidepressive Roles of Chaihu Shugan San

Zhang S, Lu Y, Chen W, Shi W, Zhao Q, Zhao J, Li L

Drug Design, Development and Therapy 2021, 15:3425-3441

Published Date: 5 August 2021

What to Do About Missed Doses? A Retrospective Study of Olanzapine in the Elderly

Xiao T, Wang Z, Li G, Huang S, Zhu X, Liu S, Li X, Hu J, Shang D, Wen Y

Drug Design, Development and Therapy 2021, 15:3411-3423

Published Date: 4 August 2021

Evidence and Current Use of Levosimendan in the Treatment of Heart Failure: Filling the Gap

Conti N, Gatti M, Raschi E, Diemberger I, Potena L

Drug Design, Development and Therapy 2021, 15:3391-3409

Published Date: 4 August 2021

COVID-19: Vaccine Delivery System, Drug Repurposing and Application of Molecular Modeling Approach

Abd El Hadi SR, Zien El-Deen EE, Bahaa MM, Sadakah AA, Yassin HA

Drug Design, Development and Therapy 2021, 15:3313-3330

Published Date: 30 July 2021

Imidazole as a Promising Medicinal Scaffold: Current Status and Future Direction

Alghamdi SS, Suliman RS, Almutairi K, Kahtani K, Aljatli D

Drug Design, Development and Therapy 2021, 15:3289-3312

Published Date: 29 July 2021

Effect of Berberine on Hyperuricemia and Kidney Injury: A Network Pharmacology Analysis and Experimental Validation in a Mouse Model

Li Q, Huang Z, Liu D, Zheng J, Xie J, Chen J, Zeng H, Su Z, Li Y

Drug Design, Development and Therapy 2021, 15:3241-3254

Published Date: 27 July 2021

Baicalin Alleviates Oxidative Stress and Inflammation in Diabetic Nephropathy via Nrf2 and MAPK Signaling Pathway

Ma L, Wu F, Shao Q, Chen G, Xu L, Lu F

Drug Design, Development and Therapy 2021, 15:3207-3221

Published Date: 21 July 2021

A Network Pharmacology-Based Investigation to the Pharmacodynamic Material Basis and Mechanisms of the Anti-Inflammatory and Anti-Viral Effect of Isatis indigotica

Deng J, Ma Y, He Y, Yang H, Chen Y, Wang L, Huang D, Qiu S, Tao X, Chen W

Drug Design, Development and Therapy 2021, 15:3193-3206

Published Date: 20 July 2021

Analysis of Clinical Trials of New Drugs for Liver Diseases in China

Lin L, Li H

Drug Design, Development and Therapy 2021, 15:3181-3191

Published Date: 20 July 2021

Baicalin Rescues Cognitive Dysfunction, Mitigates Neurodegeneration, and Exerts Anti-Epileptic Effects Through Activating TLR4/MYD88/Caspase-3 Pathway in Rats

Yang J, Jia Z, Xiao Z, Zhao J, Lu Y, Chu L, Shao H, Pei L, Zhang S, Chen Y

Drug Design, Development and Therapy 2021, 15:3163-3180

Published Date: 20 July 2021

Evaluation of Natural Bioactive-Derived Punicalagin Niosomes in Skin-Aging Processes Accelerated by Oxidant and Ultraviolet Radiation

Mohamad EA, Aly AA, Khalaf AA, Ahmed MI, Kamel RM, Abdelnaby SM, Abdelzaher YH, Sedrak MG, Mousa SA

Drug Design, Development and Therapy 2021, 15:3151-3162

Published Date: 17 July 2021

Wogonin Alleviates Kidney Tubular Epithelial Injury in Diabetic Nephropathy by Inhibiting PI3K/Akt/NF-κB Signaling Pathways

Lei L, Zhao J, Liu XQ, Chen J, Qi XM, Xia LL, Wu YG

Drug Design, Development and Therapy 2021, 15:3131-3150

Published Date: 16 July 2021

Design, Synthesis, Characterization and in vivo Antidiabetic Activity Evaluation of Some Chalcone Derivatives

Welday Kahssay S, Hailu GS, Taye Desta K

Drug Design, Development and Therapy 2021, 15:3119-3129

Published Date: 17 July 2021

The Potential Use of Ceftazidime-Avibactam Against Carbapenem Resistant Klebsiella pneumoniae Clinical Isolates Harboring Different Carbapenemase Types in a Thai University Hospital

Nasomsong W, Nulsopapon P, Changpradub D, Pongchaidecha M, Pungcharoenkijkul S, Juntanawiwat P, Simsiriporn W, Santimaleeworagun W

Drug Design, Development and Therapy 2021, 15:3095-3104

Published Date: 16 July 2021

In vitro Antimicrobial Activity of Fosfomycin, Rifampin, Vancomycin, Daptomycin Alone and in Combination Against Vancomycin-Resistant Enterococci

Tong J, Jiang Y, Xu H, Jin X, Zhang L, Ying S, Yu W, Qiu Y

Drug Design, Development and Therapy 2021, 15:3049-3055

Published Date: 12 July 2021

A Call to Action by the Italian Mesotherapy Society on Scientific Research

Mammucari M, Paolucci T, Russo D, Maggiori E, Di Marzo R, Migliore A, Massafra U, Ronconi G, Ferrara PE, Gori F, Bifarini B, Brauneis S, Vellucci R, Mediati RD, Violo B, Natoli S, Pediliggieri C, Di Campli C, Collina MC

Drug Design, Development and Therapy 2021, 15:3041-3047

Published Date: 12 July 2021

Effects of Exenatide on Coagulation and Platelet Aggregation in Patients with Type 2 Diabetes

Zhang Y, Chen R, Jia Y, Chen M, Shuai Z

Drug Design, Development and Therapy 2021, 15:3027-3040

Published Date: 12 July 2021

Review of Allopregnanolone Agonist Therapy for the Treatment of Depressive Disorders

Walkery A, Leader LD, Cooke E, VandenBerg A

Drug Design, Development and Therapy 2021, 15:3017-3026

Published Date: 9 July 2021

Total Flavone of Abelmoschus manihot Ameliorates Stress-Induced Microbial Alterations Drive Intestinal Barrier Injury in DSS Colitis

Wang R, Chen T, Wang Q, Yuan XM, Duan ZL, Feng ZY, Ding Y, Bu F, Shi GP, Chen YG

Drug Design, Development and Therapy 2021, 15:2999-3016

Published Date: 8 July 2021

Assessing Palatability of a New Amphetamine Extended-Release Tablet Formulation for the Treatment of ADHD

Pardo A, King TR, Rafla E, Kando JC

Drug Design, Development and Therapy 2021, 15:2979-2985

Published Date: 8 July 2021

Spotlight on Melphalan Flufenamide: An Up-and-Coming Therapy for the Treatment of Myeloma

Morabito F, Tripepi G, Martino EA, Vigna E, Mendicino F, Morabito L, Todoerti K, Al-Janazreh H, D’Arrigo G, Canale FA, Cutrona G, Neri A, Martino M, Gentile M

Drug Design, Development and Therapy 2021, 15:2969-2978

Published Date: 8 July 2021

Pharmacokinetic Study of Frovatriptan Succinate Tablet After Single and Multiple Oral Doses in Chinese Healthy Subjects

Zheng H, Xia Y, Qu S, Fan L, Zhang J, Ma Z, Chen Y, Fan H

Drug Design, Development and Therapy 2021, 15:2961-2968

Published Date: 7 July 2021

A Phase I Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of TPN171H, a Novel Phosphodiesterase Type 5 Inhibitor, in Healthy Subjects

Qian H, Chen Q, Liang L, Zou Y, Pu H, Xin L, Song R, Li T, Zhu H, Wang Y, Tian G, Shen J, Jiang H, Yu C, Wang Z, Jia J

Drug Design, Development and Therapy 2021, 15:2947-2959

Published Date: 6 July 2021

Mechanism of Tetrandrine Against Endometrial Cancer Based on Network Pharmacology

Shang W, Zhang J, Song H, Zhu S, Zhang A, Hua Y, Han S, Fu Y

Drug Design, Development and Therapy 2021, 15:2907-2919

Published Date: 6 July 2021

Evaluation of Ceftazidime/Avibactam Administration in Enterobacteriaceae and Pseudomonas aeruginosa Bloodstream Infections by Monte Carlo Simulation

Dai Y, Chang W, Zhou X, Yu W, Huang C, Chen Y, Ma X, Lu H, Ji R, Ying C, Wang P, Liu Z, Yuan Q, Xiao Y

Drug Design, Development and Therapy 2021, 15:2899-2905

Published Date: 6 July 2021

A Novel Folic Acid Receptor-Targeted Drug Delivery System Based on Curcumin-Loaded β-Cyclodextrin Nanoparticles for Cancer Treatment

Hong W, Guo F, Yu N, Ying S, Lou B, Wu J, Gao Y, Ji X, Wang H, Li A, Wang G, Yang G

Drug Design, Development and Therapy 2021, 15:2843-2855

Published Date: 30 June 2021

Profiling Pretomanid as a Therapeutic Option for TB Infection: Evidence to Date

Stancil SL, Mirzayev F, Abdel-Rahman SM

Drug Design, Development and Therapy 2021, 15:2815-2830

Published Date: 28 June 2021

Study on the Inhibitory Effect of Curcumin on GBM and Its Potential Mechanism

Su X, Chen S, Lu H, Li H, Qin C

Drug Design, Development and Therapy 2021, 15:2769-2781

Published Date: 28 June 2021

Progress in Redirecting Antiparasitic Drugs for Cancer Treatment

Huang H, He Q, Guo B, Xu X, Wu Y, Li X

Drug Design, Development and Therapy 2021, 15:2747-2767

Published Date: 22 June 2021

Chemistry, Pharmacology and Therapeutic Potential of Swertiamarin – A Promising Natural Lead for New Drug Discovery and Development

Muhamad Fadzil NS, Sekar M, Gan SH, Bonam SR, Wu YS, Vaijanathappa J, Ravi S, Lum PT, Dhadde SB

Drug Design, Development and Therapy 2021, 15:2721-2746

Published Date: 21 June 2021

Prospective Application of Two New Pyridine-Based Zinc (II) Amide Carboxylate in Management of Alzheimer’s Disease: Synthesis, Characterization, Computational and in vitro Approaches

Zafar R, Naureen H, Zubair M, Shahid K, Saeed Jan M, Akhtar S, Ahmad H, Waseem W, Haider A, Ali S, Tariq M, Sadiq A

Drug Design, Development and Therapy 2021, 15:2679-2694

Published Date: 21 June 2021

Immunoregulatory Effect of Acanthopanax trifoliatus (L.) Merr. Polysaccharide on T1DM Mice

Li P, Chen Y, Luo L, Yang H, Pan Y

Drug Design, Development and Therapy 2021, 15:2629-2639

Published Date: 18 June 2021

Effect of a 2-HP-β-Cyclodextrin Formulation on the Biological Transport and Delivery of Chemotherapeutic PLGA Nanoparticles

Zheng K, Huang Z, Huang J, Liu X, Ban J, Huang X, Luo H, Chen Z, Xie Q, Chen Y, Lu Z

Drug Design, Development and Therapy 2021, 15:2605-2618

Published Date: 17 June 2021

Synthesis, Radiolabeling, and Preliminary in vivo Evaluation of [68Ga] IPCAT-NOTA as an Imaging Agent for Dopamine Transporter

Farn SS, Chang KW, Lin WC, Yu HM, Lin KL, Tseng YC, Chang Y, Yu CS, Lin WJ

Drug Design, Development and Therapy 2021, 15:2577-2591

Published Date: 17 June 2021

Estrogen and Preeclampsia: Potential of Estrogens as Therapeutic Agents in Preeclampsia

Shu C, Han S, Xu P, Wang Y, Cheng T, Hu C

Drug Design, Development and Therapy 2021, 15:2543-2550

Published Date: 15 June 2021

The Current Evidence for the Use of Safinamide for the Treatment of Parkinson’s Disease

Abbruzzese G, Barone P, Lopiano L, Stocchi F

Drug Design, Development and Therapy 2021, 15:2507-2517

Published Date: 10 June 2021

Inhibitors Targeting YAP in Gastric Cancer: Current Status and Future Perspectives

Yong J, Li Y, Lin S, Wang Z, Xu Y

Drug Design, Development and Therapy 2021, 15:2445-2456

Published Date: 9 June 2021

High-Dose Dexmedetomidine Promotes Apoptosis in Fetal Rat Hippocampal Neurons

Wei Q, Chen J, Xiao F, Tu Y, Zhong Y, Xie Y

Drug Design, Development and Therapy 2021, 15:2433-2444

Published Date: 8 June 2021

Tetramethylpyrazine Improves Cognitive Function of Alzheimer’s Disease Mice by Regulating SSTR4 Ubiquitination

Weng G, Zhou B, Liu T, Huang Z, Huang S

Drug Design, Development and Therapy 2021, 15:2385-2399

Published Date: 1 June 2021

Pharmacokinetics, Tolerability and Pharmacogenetics of DA-8031 After Multiple Ascending Doses in Healthy Male Subjects

Hwang S, Lee DY, Cho JY, Chung JY, Jang IJ, Yu KS, Lee S

Drug Design, Development and Therapy 2021, 15:2375-2384

Published Date: 1 June 2021

Topical Delivery of Levocarnitine to the Cornea and Anterior Eye by Thermosensitive in-situ Gel for Dry Eye Disease

Ma B, Pang L, Huang P, Bai J, Zhang Z, Wu H, Cai M, Yang J, Xu Y, Yin X, Qu C, Ni J

Drug Design, Development and Therapy 2021, 15:2357-2373

Published Date: 2 June 2021

Cinnamaldehyde Improves Metabolic Functions in Streptozotocin-Induced Diabetic Mice by Regulating Gut Microbiota

Zhao H, Wu H, Duan M, Liu R, Zhu Q, Zhang K, Wang L

Drug Design, Development and Therapy 2021, 15:2339-2355

Published Date: 1 June 2021

Novel Phenolic Compounds as Potential Dual EGFR and COX-2 Inhibitors: Design, Semisynthesis, in vitro Biological Evaluation and in silico Insights

Abdelgawad MA, Musa A, Almalki AH, Alzarea SI, Mostafa EM, Hegazy MM, Mostafa-Hedeab G, Ghoneim MM, Parambi DGT, Bakr RB, Al-Muaikel NS, Alanazi AS, Alharbi M, Ahmad W, Bukhari SNA, Al-Sanea MM

Drug Design, Development and Therapy 2021, 15:2325-2337

Published Date: 31 May 2021

Selective Inhibition of 11β-Hydroxysteroid Dehydrogenase Type 1 Attenuates High-Fat Diet-Induced Hepatic Steatosis in Mice

Li H, Sheng J, Wang J, Gao H, Yu J, Ding G, Ding N, He W, Zha J

Drug Design, Development and Therapy 2021, 15:2309-2324

Published Date: 31 May 2021

Incidence and Risk Factors of Hepatic Fibrosis in Psoriatic Patients Receiving Methotrexate with Concomitant Acitretin Therapy and Methotrexate Monotherapy

Rattanakaemakorn P, Pinyowiwat P, Iamsumang W, Chanprapaph K, Suchonwanit P

Drug Design, Development and Therapy 2021, 15:2299-2307

Published Date: 28 May 2021

Clinical Application of Cytokines in Cancer Immunotherapy

Qiu Y, Su M, Liu L, Tang Y, Pan Y, Sun J

Drug Design, Development and Therapy 2021, 15:2269-2287

Published Date: 27 May 2021

A Review of Romiplostim Mechanism of Action and Clinical Applicability

Bussel JB, Soff G, Balduzzi A, Cooper N, Lawrence T, Semple JW

Drug Design, Development and Therapy 2021, 15:2243-2268

Published Date: 26 May 2021

Enhanced Accumulation of Cisplatin in Ovarian Cancer Cells from Combination with Wedelolactone and Resulting Inhibition of Multiple Epigenetic Drivers

Sarwar S, Alamro AA, Alghamdi AA, Naeem K, Ullah S, Arif M, Yu JQ, Huq F

Drug Design, Development and Therapy 2021, 15:2211-2227

Published Date: 25 May 2021

Fixed Dose Single Tablet Formulation with Differential Release of Amlodipine Besylate and Simvastatin and Its Pharmacokinetic Profile: QbD and Risk Assessment Approach

Kanwal U, Mukhtar S, Waheed M, Mehreen A, Abbas N, Shamim R, Hussain K, Rasool F, Hussain A, Bukhari NI

Drug Design, Development and Therapy 2021, 15:2193-2210

Published Date: 24 May 2021

Development of UPLC-MS/MS Method for Studying the Pharmacokinetic Interaction Between Dasatinib and Posaconazole in Rats

Yang S, Zhang X, Wang Y, Wen C, Wang C, Zhou Z, Lin G

Drug Design, Development and Therapy 2021, 15:2171-2178

Published Date: 24 May 2021

Effect of Dexmedetomidine on Postoperative Sleep Quality: A Systematic Review

Huang X, Lin D, Sun Y, Wu A, Wei C

Drug Design, Development and Therapy 2021, 15:2161-2170

Published Date: 21 May 2021

Toxicities and Associated Factors in Patients Receiving Temozolomide-Containing Regimens: A 12-Year Analysis of Hospital Data

Shi C, Wang X, Diao C, Zhu H, Yuan Q, Liu J, Li S, Gu M, Zhang Y

Drug Design, Development and Therapy 2021, 15:2151-2159

Published Date: 20 May 2021

Pharmacokinetics of Linezolid Dose Adjustment for Creatinine Clearance in Critically Ill Patients: A Multicenter, Prospective, Open-Label, Observational Study

Wang X, Wang Y, Yao F, Chen S, Hou Y, Zheng Z, Luo J, Qiu B, Li Z, Wang Y, Wu Z, Lan J, Chen C

Drug Design, Development and Therapy 2021, 15:2129-2141

Published Date: 19 May 2021

Canagliflozin Facilitates Reverse Cholesterol Transport Through Activation of AMPK/ABC Transporter Pathway

Zhao Y, Li Y, Liu Q, Tang Q, Zhang Z, Zhang J, Huang C, Huang H, Zhang G, Zhou J, Yan J, Xia Y, Zhang Z, He J

Drug Design, Development and Therapy 2021, 15:2117-2128

Published Date: 18 May 2021

Antifungal Efficacy and Safety of Cycloheximide as a Supplement in Optisol-GS

Dal Pizzol M, Freitas EC, Locatelli C, Guareze F, Reginatto P, Machado G, Fuentefria A, Marinho D

Drug Design, Development and Therapy 2021, 15:2091-2098

Published Date: 18 May 2021

Protective Effect of Lemon Peel Extract on Oxidative Stress in H9c2 Rat Heart Cell Injury

Wang J, Zhai Y, Ou M, Bian Y, Tang C, Zhang W, Cheng Y, Li G

Drug Design, Development and Therapy 2021, 15:2047-2058

Published Date: 14 May 2021

Silver Nanoparticle-Coated Ethyl Cellulose Inhibits Tumor Necrosis Factor-α of Breast Cancer Cells

Abdellatif AAH, Alsharidah M, Al Rugaie O, Tawfeek HM, Tolba NS

Drug Design, Development and Therapy 2021, 15:2035-2046

Published Date: 13 May 2021

PTBP1 Targets ILK to Regulate the Hypoxia-Induced Phenotypic Transformation of Pulmonary Artery Smooth Muscle Cells

Yan G, Sun R, Chen Z, Pan X, Sheng Z, Tang C

Drug Design, Development and Therapy 2021, 15:2025-2033

Published Date: 13 May 2021

FTY720 Inhibits the Development of Collagen-Induced Arthritis in Mice by Suppressing the Recruitment of CD4+ T Lymphocytes

Zhu C, Wen S, Li J, Meng H, Zhang J, Zhao K, Wang L, Zhang Y

Drug Design, Development and Therapy 2021, 15:1981-1992

Published Date: 11 May 2021

Bempedoic Acid for Heterozygous Familial Hypercholesterolemia: From Bench to Bedside

Agarwala A, Quispe R, Goldberg AC, Michos ED

Drug Design, Development and Therapy 2021, 15:1955-1963

Published Date: 10 May 2021

Consolidation Treatment and Long-Term Prognosis of Rituximab in Minimal Change Disease and Focal Segmental Glomerular Sclerosis

Lin L, Wang W, Wu Y, Xie J, Li X, Pan X, Zhang W, Xu J, Cai Y, Ren H, Chen N

Drug Design, Development and Therapy 2021, 15:1945-1953

Published Date: 10 May 2021

Potential Mechanism of S. baicalensis on Lipid Metabolism Explored via Network Pharmacology and Untargeted Lipidomics

Ge PY, Qi YY, Qu SY, Zhao X, Ni S, Yao ZY, Guo R, Yang NY, Zhang QC, Zhu HX

Drug Design, Development and Therapy 2021, 15:1915-1930

Published Date: 4 May 2021

Protective Effects of Silymarin Against D-Gal/LPS-Induced Organ Damage and Inflammation in Mice

Zhao X, Wang H, Yang Y, Gou Y, Wang Z, Yang D, Li C

Drug Design, Development and Therapy 2021, 15:1903-1914

Published Date: 4 May 2021

Study on Hepatotoxicity of Rhubarb Based on Metabolomics and Network Pharmacology

Li S, Wang Y, Li C, Yang N, Yu H, Zhou W, Chen S, Yang S, Li Y

Drug Design, Development and Therapy 2021, 15:1883-1902

Published Date: 4 May 2021

Camrelizumab Combined with FOLFOX4 Regimen as First-Line Therapy for Advanced Hepatocellular Carcinomas: A Sub-Cohort of a Multicenter Phase Ib/II Study

Li H, Qin S, Liu Y, Chen Z, Ren Z, Xiong J, Meng Z, Zhang X, Wang L, Zhang X, Zou J

Drug Design, Development and Therapy 2021, 15:1873-1882

Published Date: 3 May 2021

Exosomal Circ-XIAP Promotes Docetaxel Resistance in Prostate Cancer by Regulating miR-1182/TPD52 Axis

Zhang H, Li M, Zhang J, Shen Y, Gui Q

Drug Design, Development and Therapy 2021, 15:1835-1849

Published Date: 3 May 2021

OSU-03012 Disrupts Akt Signaling and Prevents Endometrial Carcinoma Progression in vitro and in vivo

Ding L, Ren C, Yang L, Wu Z, Li F, Jiang D, Zhu Y, Lu J

Drug Design, Development and Therapy 2021, 15:1797-1810

Published Date: 30 April 2021

Integrating Network Pharmacology and Experimental Validation to Decipher the Mechanism of Action of Huanglian Jiedu Decoction in Treating Atherosclerosis

Liang J, Huang Y, Mai Z, Zhan Q, Lin H, Xie Y, Wang H, Liu Y, Luo C

Drug Design, Development and Therapy 2021, 15:1779-1795

Published Date: 30 April 2021

Alendronate Alleviated Femoral Head Necrosis and Upregulated BMP2/EIF2AK3/EIF2A/ATF4 Pathway in Liquid Nitrogen Treated Rats

Rong K, Li X, Jiang W, Wu X, Xia Q, Chen J, Yin X

Drug Design, Development and Therapy 2021, 15:1717-1724

Published Date: 23 April 2021

Rituximab Therapy for Treatment of Pemphigus in Southeast Asians

Kanokrungsee S, Anuntrangsee T, Tankunakorn J, Srisuwanwattana P, Suchonwanit P, Chanprapaph K

Drug Design, Development and Therapy 2021, 15:1677-1690

Published Date: 22 April 2021

Lactobacillus plantarum ZS62 Alleviates Alcohol-Induced Gastric Injury in Mice via an Anti-Oxidative Mechanism

Wu Y, Hu J, Long X, Pan Y, Mu J, Park KY, Zhao X

Drug Design, Development and Therapy 2021, 15:1667-1676

Published Date: 22 April 2021

Temozolomide-Induced Changes in Gut Microbial Composition in a Mouse Model of Brain Glioma

Li XC, Wu BS, Jiang Y, Li J, Wang ZF, Ma C, Li YR, Yao J, Jin XQ, Li ZQ

Drug Design, Development and Therapy 2021, 15:1641-1652

Published Date: 21 April 2021

Population Pharmacokinetics and Safety of Oral Tetra-Arsenic Tetra-Sulfide Formula in Pediatric Acute Promyelocytic Leukemia

Zhang L, Yang XM, Chen J, Hu L, Yang F, Zhou Y, Zhao BB, Zhao W, Zhu XF

Drug Design, Development and Therapy 2021, 15:1633-1640

Published Date: 21 April 2021

In vitro Preparation and Evaluation of Sustained-Release Microcapsules of Salvianolic Acid

Wang YH, Qu T, Wang XL, Yang RP

Drug Design, Development and Therapy 2021, 15:1623-1631

Published Date: 21 April 2021

Pharmacological Management of Gastro-Esophageal Reflux Disease: An Update of the State-of-the-Art

Savarino V, Marabotto E, Zentilin P, Demarzo MG, de Bortoli N, Savarino E

Drug Design, Development and Therapy 2021, 15:1609-1621

Published Date: 19 April 2021

An Ensemble Model for Prediction of Vancomycin Trough Concentrations in Pediatric Patients

Huang X, Yu Z, Bu S, Lin Z, Hao X, He W, Yu P, Wang Z, Gao F, Zhang J, Chen J

Drug Design, Development and Therapy 2021, 15:1549-1559

Published Date: 14 April 2021

Preparation Optimization of Bovine Serum Albumin Nanoparticles and Its Application for siRNA Delivery

Wang Y, Chen S, Yang X, Zhang S, Cui C

Drug Design, Development and Therapy 2021, 15:1531-1547

Published Date: 14 April 2021

Solasodine, Isolated from Solanum sisymbriifolium Fruits, Has a Potent Anti-Tumor Activity Against Pancreatic Cancer

Fan Y, Li Z, Wu L, Lin F, Shao J, Ma X, Yao Y, Zhuang W, Wang Y

Drug Design, Development and Therapy 2021, 15:1509-1519

Published Date: 13 April 2021

Pharmaceutical Development of 5-Fluorouracil-Eluting Stents for the Potential Treatment of Gastrointestinal Cancers and Related Obstructions

Arafat M, Song Y, Brewer K, Fouladian P, Parikh A, Albrecht H, Blencowe A, Garg S

Drug Design, Development and Therapy 2021, 15:1495-1507

Published Date: 9 April 2021

Low-Dose Triple Antihypertensive Combination Therapy in Patients with Hypertension: A Randomized, Double-Blind, Phase II Study [Corrigendum]

Hong SJ, Sung KC, Lim SW, Kim SY, Kim W, Shin J, Park S, Kim HY, Rhee MY

Drug Design, Development and Therapy 2021, 15:1477-1478

Published Date: 7 April 2021

Amino Acid Conjugates of Aminothiazole and Aminopyridine as Potential Anticancer Agents: Synthesis, Molecular Docking and in vitro Evaluation

Naz S, Shah FA, Nadeem H, sarwar S, Tan Z, Imran M, Ali T, Li JB, Li S

Drug Design, Development and Therapy 2021, 15:1459-1476

Published Date: 1 April 2021

White Tip Silver Needle (Slightly Fermented White Tea) Flavonoids Help Prevent Aging via Antioxidative and Anti-Inflammatory Effects

Li C, He J, Yang Y, Gou Y, Wang Z, Chen H, Zhao X

Drug Design, Development and Therapy 2021, 15:1441-1457

Published Date: 31 March 2021

The Risks of miRNA Therapeutics: In a Drug Target Perspective [Erratum]

Zhang S, Cheng Z, Wang Y, Han T

Drug Design, Development and Therapy 2021, 15:1423-1424

Published Date: 30 March 2021

Edaravone Alleviated Propofol-Induced Neurotoxicity in Developing Hippocampus by mBDNF/TrkB/PI3K Pathway

Yang Y, Yi J, Pan M, Hu B, Duan H

Drug Design, Development and Therapy 2021, 15:1409-1422

Published Date: 30 March 2021

Caspase Cascade Activation During Apoptotic Cell Death of Human Lung Carcinoma Cells A549 Induced by Marine Sponge Callyspongia aerizusa

Hadisaputri YE, Andika R, Sopyan I, Zuhrotun A, Maharani R, Rachmat R, Abdulah R

Drug Design, Development and Therapy 2021, 15:1357-1368

Published Date: 29 March 2021

Inhibitory Effects of Periplocin on Lymphoma Cells: A Network Pharmacology Approach and Experimental Validation

Zhao R, Han C, Dai S, Wei S, Xiang X, Wang Y, Zhao R, Zhao L, Shan B

Drug Design, Development and Therapy 2021, 15:1333-1344

Published Date: 26 March 2021

Nα-1, 3-Benzenedicarbonyl-Bis-(Amino Acid) and Dipeptide Candidates: Synthesis, Cytotoxic, Antimicrobial and Molecular Docking Investigation

Naglah AM, Moustafa GO, Elhenawy AA, Mounier MM, El-Sayed H, Al-Omar MA, Almehizia AA, Bhat MA

Drug Design, Development and Therapy 2021, 15:1315-1332

Published Date: 25 March 2021

Synthesis of Michael Adducts as Key Building Blocks for Potential Analgesic Drugs: In vitro, in vivo and in silico Explorations

Ahmad S, Mahnashi MH, Alyami BA, Alqahtani YS, Ullah F, Ayaz M, Tariq M, Sadiq A, Rashid U

Drug Design, Development and Therapy 2021, 15:1299-1313

Published Date: 23 March 2021

Application of Topical Immunotherapy in the Treatment of Alopecia Areata: A Review and Update

Mahasaksiri T, Kositkuljorn C, Anuntrangsee T, Suchonwanit P

Drug Design, Development and Therapy 2021, 15:1285-1298

Published Date: 23 March 2021

Role of p38 Mitogen-Activated Protein Kinase in Asthma and COPD: Pathogenic Aspects and Potential Targeted Therapies

Pelaia C, Vatrella A, Gallelli L, Lombardo N, Sciacqua A, Savino R, Pelaia G

Drug Design, Development and Therapy 2021, 15:1275-1284

Published Date: 23 March 2021

Study on the Mechanism of Jiawei Shengjiang Powder in Improving Male Asthma-Induced Asthenospermia Based on Network Pharmacology and Bioinformatics

Wang JS, Gong XF, Feng JL, Li HS, Li X, Deng S, Ren PZ, Wang JM, Lv MS, Jin RF, Chen QY, Wang B, Cui HS

Drug Design, Development and Therapy 2021, 15:1245-1259

Published Date: 19 March 2021

Drug Discovery and Development in Rare Diseases: Taking a Closer Look at the Tafamidis Story

Burton A, Castaño A, Bruno M, Riley S, Schumacher J, Sultan MB, See Tai S, Judge DP, Patel JK, Kelly JW

Drug Design, Development and Therapy 2021, 15:1225-1243

Published Date: 18 March 2021

Potential Anti-Coronavirus Agents and the Pharmacologic Mechanisms

Yang Y, Cui X, Wei H, Guo C, Zhang Y

Drug Design, Development and Therapy 2021, 15:1213-1223

Published Date: 17 March 2021

Repeated Doses of Ketamine Affect the Infant Rat Urogenital System

Kasıkara H, Sungu N, Arslan M, Kucuk A, Ozturk L, Afandiyeva N, Kavutcu M

Drug Design, Development and Therapy 2021, 15:1157-1165

Published Date: 11 March 2021

Antibacterial and Antimicrobial Effects of Xanthorrhizol in the Prevention of Dental Caries: A Systematic Review

Khalid GS, Hamrah MH, Ghafary ES, Hosseini S, Almasi F

Drug Design, Development and Therapy 2021, 15:1149-1156

Published Date: 11 March 2021

The Efficacy and Safety of Abrocitinib as a Treatment Option for Atopic Dermatitis: A Short Report of the Clinical Data

Napolitano M, Fabbrocini G, Ruggiero A, Marino V, Nocerino M, Patruno C

Drug Design, Development and Therapy 2021, 15:1135-1147

Published Date: 10 March 2021

Withanone from Withania somnifera Attenuates SARS-CoV-2 RBD and Host ACE2 Interactions to Rescue Spike Protein Induced Pathologies in Humanized Zebrafish Model

Balkrishna A, Pokhrel S, Singh H, Joshi M, Mulay VP, Haldar S, Varshney A

Drug Design, Development and Therapy 2021, 15:1111-1133

Published Date: 11 March 2021

Safety, Tolerability and Pharmacokinetics of Single and Multiple Ascending Doses of Benfotiamine in Healthy Subjects

Sheng L, Cao W, Lin P, Chen W, Xu H, Zhong C, Yuan F, Chen H, Li H, Liu C, Yang M, Li X

Drug Design, Development and Therapy 2021, 15:1101-1110

Published Date: 9 March 2021

Investigation of the Active Ingredients and Mechanism of Polygonum cuspidatum in Asthma Based on Network Pharmacology and Experimental Verification

Bi J, Lin YH, Sun Y, Zhang M, Chen Q, Miu X, Tang L, Liu J, Zhu L, Ni Z, Wang X

Drug Design, Development and Therapy 2021, 15:1075-1089

Published Date: 9 March 2021

An Overview of Bimekizumab for the Treatment of Psoriatic Arthritis: The Evidence so Far

G Oliveira D, Faria R, Torres T

Drug Design, Development and Therapy 2021, 15:1045-1053

Published Date: 9 March 2021

Role of Oxidative Stress and Reduced Endogenous Hydrogen Sulfide in Diabetic Nephropathy

Hussain Lodhi A, Ahmad FUD, Furwa K, Madni A

Drug Design, Development and Therapy 2021, 15:1031-1043

Published Date: 5 March 2021

Epigallocatechin-3-Gallate Promotes the in vitro Maturation and Embryo Development Following IVF of Porcine Oocytes

Huang K, Li C, Gao F, Fan Y, Zeng F, Meng L, Li L, Zhang S, Wei H

Drug Design, Development and Therapy 2021, 15:1013-1020

Published Date: 4 March 2021

The Effect of Nintedanib on T-Cell Activation, Subsets and Functions

Ubieta K, Thomas MJ, Wollin L

Drug Design, Development and Therapy 2021, 15:997-1011

Published Date: 8 March 2021

Dihydroartemisinin Inhibits TGF-β-Induced Fibrosis in Human Tenon Fibroblasts via Inducing Autophagy

Wang X, Song W, Zhang F, Huang R

Drug Design, Development and Therapy 2021, 15:973-981

Published Date: 3 March 2021

Characterization of Oxygenated Heterocyclic Compounds and in vitro Antioxidant Activity of Pomelo Essential Oil

Li G, Cheng Y, Zhang T, Li Y, Han L, Liang G

Drug Design, Development and Therapy 2021, 15:937-947

Published Date: 2 March 2021

Lidocaine Inhibits Myoblast Cell Migration and Myogenic Differentiation Through Activation of the Notch Pathway

Ling X, Ma X, Kuang X, Zou Y, Zhang H, Tang H, Du H, Zhu B, Huang H, Xia Q, Chen M, Mao D, Chen D, Shen H, Yan J

Drug Design, Development and Therapy 2021, 15:927-936

Published Date: 2 March 2021

Bitter Taste Receptor as a Therapeutic Target in Orthopaedic Disorders

Cheng W, Yao M, Liu F

Drug Design, Development and Therapy 2021, 15:895-903

Published Date: 26 February 2021

Low Frequency of Integrase Inhibitor Resistance Mutations Among Therapy-Naïve HIV Patients in Southeast China

Lai J, Liu Y, Han X, Huang A, Lin J, Ao W, Ye H, Chen Y

Drug Design, Development and Therapy 2021, 15:889-894

Published Date: 26 February 2021

Effects of Sugammadex versus Neostigmine on Intraoperative Coagulation Profiles in Patients with Thyroidectomy

Zhao D, Fang J, Xiong W, Lin J, Chen W, Wu C

Drug Design, Development and Therapy 2021, 15:829-834

Published Date: 25 February 2021

Efficacy and Safety of Retinol Palmitate Ophthalmic Solution in the Treatment of Dry Eye: A Japanese Phase II Clinical Trial [Corrigendum]

Toshida H, Funaki T, Ono K, Tabuchi N, Watanabe S, Seki T, Otake H, Kato T, Ebihara N, Murakami A

Drug Design, Development and Therapy 2021, 15:813-816

Published Date: 24 February 2021

Convallatoxin Promotes M2 Macrophage Polarization to Attenuate Atherosclerosis Through PPARγ-Integrin αvβ5 Signaling Pathway

Zhang Y, Shi X, Han J, Peng W, Fang Z, Zhou Y, Xu X, Lin J, Xiao F, Zhao L, Lin Y

Drug Design, Development and Therapy 2021, 15:803-812

Published Date: 23 February 2021

Mechanism of Action of Xiaoyao San in Treatment of Ischemic Stroke is Related to Anti-Apoptosis and Activation of PI3K/Akt Pathway

Xu Y, Chen W, Chen Z, Huang M, Yang F, Zhang Y

Drug Design, Development and Therapy 2021, 15:753-767

Published Date: 22 February 2021

The Effectiveness of Ruxolitinib for Acute/Chronic Graft-versus-Host Disease in Children: A Retrospective Study

Yang W, Zhu G, Qin M, Li Z, Wang B, Yang J, Wang T

Drug Design, Development and Therapy 2021, 15:743-752

Published Date: 22 February 2021

Addition of Celebrex and Pregabalin to Ropivacaine for Posterior Spinal Surgery: A Randomized, Double-Blinded, Placebo-Controlled Trial

Zhang Y, He B, Zhao J, Zhang M, Ren Q, Zhang W, Xu S, Quan Z, Ou Y

Drug Design, Development and Therapy 2021, 15:735-742

Published Date: 22 February 2021

The Risks of miRNA Therapeutics: In a Drug Target Perspective

Zhang S, Cheng Z, Wang Y, Han T

Drug Design, Development and Therapy 2021, 15:721-733

Published Date: 22 February 2021

Danggui Buxue Decoction in the Treatment of Metastatic Colon Cancer: Network Pharmacology Analysis and Experimental Validation

Feng SH, Zhao B, Zhan X, Motanyane R, Wang SM, Li A

Drug Design, Development and Therapy 2021, 15:705-720

Published Date: 24 February 2021

Glucocorticoid-Like Activity of Escin: A New Mechanism for an Old Drug

Gallelli L, Cione E, Wang T, Zhang L

Drug Design, Development and Therapy 2021, 15:699-704

Published Date: 24 February 2021

Trans-Cinnamaldehyde Increases Random Pattern Flap Survival Through Activation of the Nitric Oxide Pathway

Luo X, Zhao B, Chen B, Chen H, Han T, Bsoul NBN, Yan H

Drug Design, Development and Therapy 2021, 15:679-688

Published Date: 18 February 2021

Thiazole-Based Thiosemicarbazones: Synthesis, Cytotoxicity Evaluation and Molecular Docking Study

Gomha SM, Abdelhady HA, Hassain DZH, Abdelmonsef AH, El-Naggar M, Elaasser MM, Mahmoud HK

Drug Design, Development and Therapy 2021, 15:659-677

Published Date: 17 February 2021

Progress in Clinical Research on Gonadotropin-Releasing Hormone Receptor Antagonists for the Treatment of Prostate Cancer

Liu YF, Fu SQ, Yan YC, Gong BB, Xie WJ, Yang XR, Sun T, Ma M

Drug Design, Development and Therapy 2021, 15:639-649

Published Date: 16 February 2021

Effect of Different Dosage Frequency of Polymyxin B on Rat Nephrotoxicity

Sun W, Hu B, Zhang X, Wang Y, Xiang Z, Lin G

Drug Design, Development and Therapy 2021, 15:611-616

Published Date: 16 February 2021

Effects of Quercetin on the Efficacy of Various Chemotherapeutic Drugs in Cervical Cancer Cells

Xu W, Xie S, Chen X, Pan S, Qian H, Zhu X

Drug Design, Development and Therapy 2021, 15:577-588

Published Date: 15 February 2021

Self-Nanoemulsifying Drug Delivery System of Genkwanin: A Novel Approach for Anti-Colitis-Associated Colorectal Cancer

Yin HF, Yin CM, Ouyang T, Sun SD, Chen WG, Yang XL, He X, Zhang CF

Drug Design, Development and Therapy 2021, 15:557-576

Published Date: 12 February 2021

Magnesium Isoglycyrrhizinate Alleviates Arsenic Trioxide-Induced Cardiotoxicity: Contribution of Nrf2 and TLR4/NF-κB Signaling Pathway

Zheng B, Yang Y, Li J, Li J, Zuo S, Chu X, Xu S, Ma D, Chu L

Drug Design, Development and Therapy 2021, 15:543-556

Published Date: 12 February 2021

Synergistic Anticancer Strategy of Sonodynamic Therapy Combined with PI-103 Against Hepatocellular Carcinoma

Yang H, Jing H, Han X, Tan H, Cheng W

Drug Design, Development and Therapy 2021, 15:531-542

Published Date: 11 February 2021

L-Cysteine Provides Neuroprotection of Hypoxia-Ischemia Injury in Neonatal Mice via a PI3K/Akt-Dependent Mechanism

Li T, Li J, Li T, Zhao Y, Ke H, Wang S, Liu D, Wang Z

Drug Design, Development and Therapy 2021, 15:517-529

Published Date: 11 February 2021

Loganin Attenuates Septic Acute Renal Injury with the Participation of AKT and Nrf2/HO-1 Signaling Pathways

Zhang J, Wang C, Kang K, Liu H, Liu X, Jia X, Yu K

Drug Design, Development and Therapy 2021, 15:501-513

Published Date: 11 February 2021

EGCG Regulates Cell Apoptosis of Human Umbilical Vein Endothelial Cells Grown on 316L Stainless Steel for Stent Implantation

Wang J, Wang Y, Zhao Y, Zhao J, Zhang B, Xu K

Drug Design, Development and Therapy 2021, 15:493-499

Published Date: 11 February 2021

Profile of Enfortumab Vedotin in the Treatment of Urothelial Carcinoma: The Evidence to Date

Moussa M, Papatsoris A, Abou Chakra M, Dellis A

Drug Design, Development and Therapy 2021, 15:453-462

Published Date: 11 February 2021

Effect of Evodiamine on Rat Colonic Hypermotility Induced by Water Avoidance Stress and the Underlying Mechanism

Ren H, Yuan F, Tan W, Ding Y, An P, Luo H

Drug Design, Development and Therapy 2021, 15:441-452

Published Date: 10 February 2021

Design, Synthesis, Molecular Modelling, and Biological Evaluation of Oleanolic Acid-Arylidene Derivatives as Potential Anti-Inflammatory Agents

Hassan Mir R, Godavari G, Siddiqui NA, Ahmad B, Mothana RA, Ullah R, Almarfadi OM, Jachak SM, Masoodi MH

Drug Design, Development and Therapy 2021, 15:385-397

Published Date: 4 February 2021

Thiazolidine Derivatives Attenuate Carrageenan-Induced Inflammatory Pain in Mice

Malik Z, Abbas M, Al Kury LT, Shah FA, Alam M, Khan AU, Nadeem H, Alghamdi S, Sahibzada MUK, Li S

Drug Design, Development and Therapy 2021, 15:369-384

Published Date: 4 February 2021

Irisin Protects Against Hind Limb Ischemia Reperfusion Injury

Küçük A, Polat Y, Kılıçarslan A, Süngü N, Kartal H, Dursun AD, Arslan M

Drug Design, Development and Therapy 2021, 15:361-368

Published Date: 4 February 2021

New Approach in Ocular Drug Delivery: In vitro and ex vivo Investigation of Cyclodextrin-Containing, Mucoadhesive Eye Drop Formulations

Bíró T, Bocsik A, Jurišić Dukovski B, Gróf I, Lovrić J, Csóka I, Deli MA, Aigner Z

Drug Design, Development and Therapy 2021, 15:351-360

Published Date: 3 February 2021

CircNRIP1 Modulates the miR-515-5p/IL-25 Axis to Control 5-Fu and Cisplatin Resistance in Nasopharyngeal Carcinoma

Lin J, Qin H, Han Y, Li X, Zhao Y, Zhai G

Drug Design, Development and Therapy 2021, 15:323-330

Published Date: 27 January 2021

Phenotyping Study of Cyclophosphamide 4-Hydroxylation in Malay Cancer Patients

Fityatal Hasanah YI, Harahap Y, Purwanto DJ

Drug Design, Development and Therapy 2021, 15:305-313

Published Date: 26 January 2021

Physcion Protects Rats Against Cerebral Ischemia-Reperfusion Injury via Inhibition of TLR4/NF-kB Signaling Pathway

Dong X, Wang L, Song G, Cai X, Wang W, Chen J, Wang G

Drug Design, Development and Therapy 2021, 15:277-287

Published Date: 25 January 2021

Effects of Caffeic Acid and Its Derivatives on Bone: A Systematic Review

Ekeuku SO, Pang KL, Chin KY

Drug Design, Development and Therapy 2021, 15:259-275

Published Date: 22 January 2021

Paeoniflorin Sensitizes Breast Cancer Cells to Tamoxifen by Downregulating microRNA-15b via the FOXO1/CCND1/β-Catenin Axis

Wang Y, Wang Q, Li X, Luo G, Shen M, Shi J, Wang X, Tang L

Drug Design, Development and Therapy 2021, 15:245-257

Published Date: 22 January 2021

Gracillin Isolated from Reineckia carnea Induces Apoptosis of A549 Cells via the Mitochondrial Pathway

Yang J, Cao L, Li Y, Liu H, Zhang M, Ma H, Wang B, Yuan X, Liu Q

Drug Design, Development and Therapy 2021, 15:233-243

Published Date: 20 January 2021

Galangin Improved Non-Alcoholic Fatty Liver Disease in Mice by Promoting Autophagy [Corrigendum]

Zhang X, Deng Y, Xiang J, Liu H, Zhang J, Liao J, Chen K, Liu B, Liu J, Pu Y

Drug Design, Development and Therapy 2021, 15:231-232

Published Date: 20 January 2021

Clinical Significance of Continuable Treatment with Nintedanib Over 12 Months for Idiopathic Pulmonary Fibrosis in a Real-World Setting

Kato M, Sasaki S, Tateyama M, Arai Y, Motomura H, Sumiyoshi I, Ochi Y, Watanabe J, Ihara H, Togo S, Takahashi K

Drug Design, Development and Therapy 2021, 15:223-230

Published Date: 18 January 2021

H2O2-Inactivated Salmonella typhimurium RE88 Strain as a New Cancer Vaccine Carrier: Evaluation in a Mouse Model of Cancer

Fan Y, Bai T, Tian Y, Zhou B, Wang Y, Yang L

Drug Design, Development and Therapy 2021, 15:209-222

Published Date: 15 January 2021

Quaternary Lidocaine Derivatives: Past, Present, and Future

Wang Q, Zhang Y, Liu J, Zhang W

Drug Design, Development and Therapy 2021, 15:195-207

Published Date: 14 January 2021

Bioequivalence and Pharmacokinetic Profiles of Generic and Branded Obeticholic Acid in Healthy Chinese Subjects Under Fasting and Fed Conditions

Wang MN, Yu HT, Li YQ, Zeng Y, Yang S, Yang GP, Pei Q, Huang J

Drug Design, Development and Therapy 2021, 15:185-193

Published Date: 14 January 2021

Combination of Sodium Cantharidinate with Cisplatin Synergistically Hampers Growth of Cervical Cancer

Chen X, Zhou M, Fan W, Yang M, Yang L

Drug Design, Development and Therapy 2021, 15:171-183

Published Date: 13 January 2021

Subcutaneous Delivery of High-Dose/Volume Biologics: Current Status and Prospect for Future Advancements

Badkar AV, Gandhi RB, Davis SP, LaBarre MJ

Drug Design, Development and Therapy 2021, 15:159-170

Published Date: 13 January 2021

Capsaicin Inhibits Proliferation and Induces Apoptosis in Breast Cancer by Down-Regulating FBI-1-Mediated NF-κB Pathway

Chen M, Xiao C, Jiang W, Yang W, Qin Q, Tan Q, Lian B, Liang Z, Wei C

Drug Design, Development and Therapy 2021, 15:125-140

Published Date: 12 January 2021

Chronic Obstructive Pulmonary Disease Treatment and Pharmacist-Led Medication Management

Li LC, Han YY, Zhang ZH, Zhou WC, Fang HM, Qu J, Kan LD

Drug Design, Development and Therapy 2021, 15:111-124

Published Date: 12 January 2021

Network Pharmacology and Experimental Evidence Identify the Mechanism of Astragaloside IV in Oxaliplatin Neurotoxicity

Xu J, Guan Z, Wang X, Sun D, Li Y, Pei B, Lu Y, Yuan L, Zhang X

Drug Design, Development and Therapy 2021, 15:99-110

Published Date: 12 January 2021

A Review of Drug Therapy in Vestibular Schwannoma

Long J, Zhang Y, Huang X, Ren J, Zhong P, Wang B

Drug Design, Development and Therapy 2021, 15:75-85

Published Date: 8 January 2021

Inhibition of Pre-B Cell Colony Enhancing Factor Reduces Lung Injury in Rats Receiving Cardiopulmonary Bypass

Lu C, Yang W, Zhou J, Zhang Z, Gong Y, Hu F, Yu W, Dong X

Drug Design, Development and Therapy 2021, 15:51-60

Published Date: 7 January 2021

RASSF1A Enhances Chemosensitivity of NSCLC Cells Through Activating Autophagy by Regulating MAP1S to Inactivate Keap1-Nrf2 Pathway

Wang J, Zhang X, Yang F, Yang Y, Wang T, Liu W, Zhou H, Zhao W

Drug Design, Development and Therapy 2021, 15:21-35

Published Date: 6 January 2021

Current Status and Perspectives of Protease Inhibitors and Their Combination with Nanosized Drug Delivery Systems for Targeted Cancer Therapy

Rudzińska M, Daglioglu C, Savvateeva LV, Kaci FN, Antoine R, Zamyatnin Jr AA

Drug Design, Development and Therapy 2021, 15:9-20

Published Date: 6 January 2021