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Drug Design, Development and Therapy
ISSN: 1177-8881
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Archive: Volume 15, 2021
Identification of Active Ingredients of Huangqi Guizhi Wuwu Decoction for Promoting Nerve Function Recovery After Ischemic Stroke Using HT22 Live-Cell-Based Affinity Chromatography Combined with HPLC-MS/MS
He Y, Zheng H, Zhong L, Zhong N, Wen G, Wang L, Zhang Y
Drug Design, Development and Therapy 2021, 15:5165-5178
Published Date: 30 December 2021
Lactobacillus fermentum CQPC08 Attenuates Exercise-Induced Fatigue in Mice Through Its Antioxidant Effects and Effective Intervention of Galactooligosaccharide
Liu D, Liu DC, Fan H, Wang Y
Drug Design, Development and Therapy 2021, 15:5151-5164
Published Date: 24 December 2021
Dynamics of Endocytosis and Degradation of Antibody-Drug Conjugate T-DM1 in HER2 Positive Cancer Cells
Liang K, Mei S, Gao X, Peng S, Zhan J
Drug Design, Development and Therapy 2021, 15:5135-5150
Published Date: 24 December 2021
In vitro Preparation and Evaluation of Sustained-Release Microcapsules of Salvianolic Acid [Retraction]
Wang YH, Qu T, Wang XL, Yang RP
Drug Design, Development and Therapy 2021, 15:5133-5134
Published Date: 23 December 2021
Downregulation of IRF2 Alleviates Sepsis-Related Acute Kidney Injury in vitro and in vivo
Zhang Y, Zhang Y, Yang A, Xia F
Drug Design, Development and Therapy 2021, 15:5123-5132
Published Date: 22 December 2021
Simultaneous Determination of Loratadine and Its Metabolite Desloratadine in Beagle Plasma by LC-MS/MS and Application for Pharmacokinetics Study of Loratadine Tablets and Omeprazole‑Induced Drug–Drug Interaction
Zhang Y, Zhang J, Xu Q, Wang Y, Wu W, Wang W, Li X, Zhang T
Drug Design, Development and Therapy 2021, 15:5109-5122
Published Date: 22 December 2021
Comparative Pharmacokinetics/Pharmacodynamics of Fixed-Dose Combination of Esomeprazole and Calcium Carbonate (AD-206) to the Conventional Esomeprazole
Bae S, Kwon J, Lee SB, Jang IJ, Yu KS, Lee S
Drug Design, Development and Therapy 2021, 15:5099-5108
Published Date: 21 December 2021
Progestin-Primed Ovarian Stimulation with Clomiphene Citrate Supplementation May Be More Feasible for Young Women with Diminished Ovarian Reserve Compared with Standard Progestin-Primed Ovarian Stimulation: A Retrospective Study
Lin Y, Chen Q, Zhu J, Teng Y, Huang X, Chen X
Drug Design, Development and Therapy 2021, 15:5087-5097
Published Date: 21 December 2021
Val109Asp Polymorphism of the Omentin-1 Gene and Incidence of Knee Osteoarthritis in a Chinese Han Population: A Correlation Analysis
Chen R, Zhang Y, Xu H, Hu H, Chen M, Shuai Z
Drug Design, Development and Therapy 2021, 15:5075-5086
Published Date: 21 December 2021
Establishment of Sunitinib-Resistant Xenograft Model of Renal Cell Carcinoma and the Identification of Drug-Resistant Hub Genes and Pathways
Xie Y, Shangguan W, Chen Z, Zheng Z, Chen Y, Zhong Q, Zhang Y, Yang J, Zhu D, Xie W
Drug Design, Development and Therapy 2021, 15:5061-5074
Published Date: 16 December 2021
Drug Repurposing: Deferasirox Inhibits the Anti-Apoptotic Activity of Mcl-1
Bourafai-Aziez A, Benabderrahmane M, Paysant H, Weiswald LB, Poulain L, Carlier L, Ravault D, Jouanne M, Coadou G, Oulyadi H, Voisin-Chiret AS, Sopková-de Oliveira Santos J, Sebban M
Drug Design, Development and Therapy 2021, 15:5035-5059
Published Date: 15 December 2021
Effect of Different Concentrations of Esmolol on Perioperative Hemodynamics and Analgesia in Patients Undergoing Colectomy: A Prospective, Randomized Controlled Study
Song F, Jin Y, Li P, Zheng C, Zhao X
Drug Design, Development and Therapy 2021, 15:5025-5033
Published Date: 14 December 2021
(Rose Bengal)/(Eosin Yellow)-Gold-Polypyrrole Hybrids: A Design for Dual Photo-Active Nano-System with Ultra-High Loading Capacity
El-Kholy AI, Abdel Fadeel D, Nasr M, Fadel M, El-Sherbiny I
Drug Design, Development and Therapy 2021, 15:5011-5023
Published Date: 14 December 2021
Bio-Guided Isolation of Two New Hypoglycemic Triterpenoid Saponins from Polygonum capitatum
Huang D, Du Z, Chen Y, Dong Z, Wang X, Li M, Zhang F, Chen W, Sun L
Drug Design, Development and Therapy 2021, 15:5001-5010
Published Date: 14 December 2021
Pro-Angiogenic Effects of Essential Oil from Perilla frutescens and Its Main Component (Perillaldehyde) on Zebrafish Embryos and Human Umbilical Vein Endothelial Cells
Zhou F, Dai O, Peng C, Xiong L, Ao H, Liu F, Zhou QM
Drug Design, Development and Therapy 2021, 15:4985-4999
Published Date: 11 December 2021
Knockdown of TRIM8 Protects HK-2 Cells Against Hypoxia/Reoxygenation-Induced Injury by Inhibiting Oxidative Stress-Mediated Apoptosis and Pyroptosis via PI3K/Akt Signal Pathway
Zhang BH, Liu H, Yuan Y, Weng XD, Du Y, Chen H, Chen ZY, Wang L, Liu XH
Drug Design, Development and Therapy 2021, 15:4973-4983
Published Date: 10 December 2021
Cell-Penetrating Peptide-Modified Graphene Oxide Nanoparticles Loaded with Rictor siRNA for the Treatment of Triple-Negative Breast Cancer
Yang YY, Zhang W, Liu H, Jiang JJ, Wang WJ, Jia ZY
Drug Design, Development and Therapy 2021, 15:4961-4972
Published Date: 10 December 2021
New Progress in Improving the Delivery Methods of Bisphosphonates in the Treatment of Bone Tumors
Zhong Y, Li S
Drug Design, Development and Therapy 2021, 15:4939-4959
Published Date: 10 December 2021
Effects of Dezocine and Sufentanil on Th1/Th2 Balance in Breast Cancer Patients Undergoing Surgery
Hu X, Luo B, Wu Q, Chen Q, Lu P, Huang J, Liang X, Ling C, Li Y
Drug Design, Development and Therapy 2021, 15:4925-4938
Published Date: 2 December 2021
Network Pharmacology and Experimental Validation to Reveal the Pharmacological Mechanisms of Liuwei Dihuang Decoction Against Intervertebral Disc Degeneration
Zhang H, Yao S, Zhang Z, Zhou C, Fu F, Bian Y, Luo H, Li Y, Yan S, Ge Y, Chen Y, Zhan K, Ge Y, Chen Z, Yue M, Li X, Du W, Jin H, Tong P, Ruan H, Wu C
Drug Design, Development and Therapy 2021, 15:4911-4924
Published Date: 2 December 2021
Protective Effects of Mogroside V on Oxidative Stress Induced by H2O2 in Skin Fibroblasts
Mo Q, Fu H, Zhao D, Zhang J, Wang C, Wang D, Li M
Drug Design, Development and Therapy 2021, 15:4901-4909
Published Date: 1 December 2021
Ventilagolin Suppresses Migration, Invasion and Epithelial-Mesenchymal Transition of Hepatocellular Carcinoma Cells by Downregulating Pim-1
Liu Y, Cheng DH, Lai KD, Su H, Lu GS, Wang L, Lv JH
Drug Design, Development and Therapy 2021, 15:4885-4899
Published Date: 1 December 2021
Ruxolitinib for Treatment of Steroid-Refractory Graft-versus-Host Disease: Real-World Data from Chinese Patients
Wei C, Zhang X, Liang D, Yang J, Du J, Yue C, Deng L
Drug Design, Development and Therapy 2021, 15:4875-4883
Published Date: 30 November 2021
The Pharmacokinetic Effect of Itraconazole and Voriconazole on Ripretinib in Beagle Dogs by UPLC-MS/MS Technique
Wang H, Zhou C, Su Y, Gou K, Geng X, Qiu X
Drug Design, Development and Therapy 2021, 15:4865-4873
Published Date: 30 November 2021
New Insights of Anti-Hyperglycemic Agents and Traditional Chinese Medicine on Gut Microbiota in Type 2 Diabetes
Chen Y, Wang M
Drug Design, Development and Therapy 2021, 15:4849-4863
Published Date: 30 November 2021
Methylcobalamin Protects Melanocytes from H2O2-Induced Oxidative Stress by Activating the Nrf2/HO-1 Pathway
An R, Li D, Dong Y, She Q, Zhou T, Nie X, Pan R, Deng Y
Drug Design, Development and Therapy 2021, 15:4837-4848
Published Date: 30 November 2021
UPLC–MS/MS and Network Pharmacology-Based Analysis of Bioactive Anti-Depression Compounds in Betel Nut
Yang Y, Huang H, Cui Z, Chu J, Du G
Drug Design, Development and Therapy 2021, 15:4827-4836
Published Date: 30 November 2021
Oroxin B Attenuates Ovariectomy-Induced Bone Loss by Suppressing Osteoclast Formation and Activity
Huang JM, Wang CZ, Lu SY, Wang Z, Yan ZQ
Drug Design, Development and Therapy 2021, 15:4811-4825
Published Date: 30 November 2021
Berberine Influences the Survival of Fat Grafting by Inhibiting Autophagy and Apoptosis of Human Adipose Derived Mesenchymal Stem Cells
Pang H, Zhou Y, Wang J, Wu H, Liu X, Gao F, Xiao Z
Drug Design, Development and Therapy 2021, 15:4795-4809
Published Date: 30 November 2021
Toxicological Evaluation of a Probiotic-Based Delivery System for P8 Protein as an Anti-Colorectal Cancer Drug
An BC, Yoon YS, Park HJ, Park S, Kim TY, Ahn JY, Kwon D, Choi O, Heo JY, Ryu Y, Kim JH, Eom H, Chung MJ
Drug Design, Development and Therapy 2021, 15:4761-4793
Published Date: 27 November 2021
Hearing Protection Outcomes of Analog Electrode Arrays Coated with Different Drug-Eluting Polymer Films Implanted into Guinea Pig Cochleae [Corrigendum]
Huang Y, Yu H, Liang M, Hou S, Chen JM, Zhang F, Sun X, Jia H, Yang J
Drug Design, Development and Therapy 2021, 15:4759-4760
Published Date: 24 November 2021
Inhibition of Lipopolysaccharide-Induced Inflammatory Bone Loss by Saikosaponin D is Associated with Regulation of the RANKL/RANK Pathway
Wu X, Zhao K, Fang X, Lu F, Zhang W, Song X, Chen L, Sun J, Chen H
Drug Design, Development and Therapy 2021, 15:4741-4757
Published Date: 23 November 2021
Clinical Effect of Doxycycline Combined with Compound Sulfamethoxazole and Rifampicin in the Treatment of Brucellosis Spondylitis
Yang XM, Jia YL, Zhang Y, Zhang PN, Yao Y, Yin YL, Tian Y
Drug Design, Development and Therapy 2021, 15:4733-4740
Published Date: 23 November 2021
Therapeutic Effects and Safe Uses of Plant-Derived Polyphenolic Compounds in Cardiovascular Diseases: A Review
Alotaibi BS, Ijaz M, Buabeid M, Kharaba ZJ, Yaseen HS, Murtaza G
Drug Design, Development and Therapy 2021, 15:4713-4732
Published Date: 20 November 2021
Antifungal Effects and Potential Mechanisms of Benserazide Hydrochloride Alone and in Combination with Fluconazole Against Candida albicans
Chen X, Wu J, Sun L, Nie J, Su S, Sun S
Drug Design, Development and Therapy 2021, 15:4701-4711
Published Date: 16 November 2021
Activation of GPR18 by Resolvin D2 Relieves Pain and Improves Bladder Function in Cyclophosphamide-Induced Cystitis Through Inhibiting TRPV1
Lu Q, Yang Y, Zhang H, Chen C, Zhao J, Yang Z, Fan Y, Li L, Feng H, Zhu J, Yi S
Drug Design, Development and Therapy 2021, 15:4687-4699
Published Date: 15 November 2021
The Efficacy and Safety of Remimazolam Tosilate versus Etomidate-Propofol in Elderly Outpatients Undergoing Colonoscopy: A Prospective, Randomized, Single-Blind, Non-Inferiority Trial
Liu X, Ding B, Shi F, Zhang Y, Liu L, Sha Y, Zhao T
Drug Design, Development and Therapy 2021, 15:4675-4685
Published Date: 16 November 2021
A Retrospective Cohort Study Evaluates Clinical Value of Anlotinib in Persistent, Metastatic, or Recurrent Cervical Cancer After Failure of First-Line Therapy
Yang H, Sun S, Mei Z, Xiang Q, Yang C, Chen M, Xie C, Zhou Y, Qiu H
Drug Design, Development and Therapy 2021, 15:4665-4674
Published Date: 16 November 2021
A New Strategy for the Rapid Identification and Validation of the Direct Targets of Aconitine-Induced Cardiotoxicity
Wei J, Fan S, Yu H, Shu L, Li Y
Drug Design, Development and Therapy 2021, 15:4649-4664
Published Date: 13 November 2021
The Effect of Metformin on the Proliferation, Apoptosis and CD133 mRNA Expression of Colon Cancer Stem Cells by Upregulation of miR 342-3p
Zhang Y, Chen R, Deng L, Shuai Z, Chen M
Drug Design, Development and Therapy 2021, 15:4633-4647
Published Date: 11 November 2021
A review on the molecular basis underlying the protective effects of Andrographis paniculata and andrographolide against myocardial injury
Wong SK, Chin KY, Ima-Nirwana S
Drug Design, Development and Therapy 2021, 15:4615-4632
Published Date: 10 November 2021
Transdermal Delivery of Telmisartan: Formulation, in vitro, ex vivo, Iontophoretic Permeation Enhancement and Comparative Pharmacokinetic Study in Rats
Teaima M, Abdelmonem R, Adel YA, El-Nabarawi MA, El-Nawawy TM
Drug Design, Development and Therapy 2021, 15:4603-4614
Published Date: 10 November 2021
Exploring the Underlying Mechanism of Shenyankangfu Tablet in the Treatment of Glomerulonephritis Through Network Pharmacology, Machine Learning, Molecular Docking, and Experimental Validation
Jin M, Ren W, Zhang W, Liu L, Yin Z, Li D
Drug Design, Development and Therapy 2021, 15:4585-4601
Published Date: 9 November 2021
A Validated HPLC-MS/MS Method for Quantification of Methotrexate and Application for Therapeutic Drug Monitoring in Children and Adults with Non-Hodgkin Lymphoma
Feng Z, Gao J, Gao X, Hua L, Nie X, Sun Y, Wang M
Drug Design, Development and Therapy 2021, 15:4575-4583
Published Date: 5 November 2021
Prunella vulgaris L. Attenuates Experimental Autoimmune Thyroiditis by Inhibiting HMGB1/TLR9 Signaling
Guo Q, Qu H, Zhang H, Zhong X
Drug Design, Development and Therapy 2021, 15:4559-4574
Published Date: 4 November 2021
Efficacy of Pre-Treatment with Remimazolam on Prevention of Propofol-Induced Injection Pain in Patients Undergoing Abortion or Curettage: A Prospective, Double-Blinded, Randomized and Placebo-Controlled Clinical Trial
Guan X, Jiao Z, Gong X, Cao H, Liu S, Lan H, Huang X, Tan Y, Xu B, Lin C
Drug Design, Development and Therapy 2021, 15:4551-4558
Published Date: 4 November 2021
Chemistry, Biosynthesis, Physicochemical and Biological Properties of Rubiadin: A Promising Natural Anthraquinone for New Drug Discovery and Development
Watroly MN, Sekar M, Fuloria S, Gan SH, Jeyabalan S, Wu YS, Subramaniyan V, Sathasivam KV, Ravi S, Mat Rani NNI, Lum PT, Vaijanathappa J, Meenakshi DU, Mani S, Fuloria NK
Drug Design, Development and Therapy 2021, 15:4527-4549
Published Date: 3 November 2021
Anti-Inflammatory Effects of Curcumin in the Inflammatory Diseases: Status, Limitations and Countermeasures
Peng Y, Ao M, Dong B, Jiang Y, Yu L, Chen Z, Hu C, Xu R
Drug Design, Development and Therapy 2021, 15:4503-4525
Published Date: 2 November 2021
Artemisinin Improves Acetylcholine-Induced Vasodilatation in Rats with Primary Hypertension
Liu X, Wang X, Pan Y, Zhao L, Sun S, Luo A, Bao C, Tang H, Han Y
Drug Design, Development and Therapy 2021, 15:4489-4502
Published Date: 2 November 2021
An Industrial Procedure for Pharmacodynamic Improvement of Metformin HCl via Granulation with Its Paracellular Pathway Enhancer Using Factorial Experimental Design
Mady OY, Al-Shoubki AA, Donia AA
Drug Design, Development and Therapy 2021, 15:4469-4487
Published Date: 2 November 2021
Enhancement of Cancer Chemotherapeutic Efficacy via Bone-Targeted Drug Delivery Carrier in Bone Metastases
Xue X, Yu J, Lu F, Jiang H, Wang X
Drug Design, Development and Therapy 2021, 15:4455-4468
Published Date: 28 October 2021
An Overview on the Potential Roles of EGCG in the Treatment of COVID-19 Infection
Bimonte S, Forte CA, Cuomo M, Esposito G, Cascella M, Cuomo A
Drug Design, Development and Therapy 2021, 15:4447-4454
Published Date: 28 October 2021
Cinobufagin Suppresses the Characteristics of Osteosarcoma Cancer Cells by Inhibiting the IL-6-OPN-STAT3 Pathway [Retraction]
Zhang C, Ma K, Li WY
Drug Design, Development and Therapy 2021, 15:4445-4446
Published Date: 27 October 2021
Effect of 2% Hyaluronic Acid on the Rate of Healing of Corneal Epithelial Defect After Pterygium Surgery: A Randomized Controlled Trial
Chaidaroon W, Satayawut N, Tananuvat N
Drug Design, Development and Therapy 2021, 15:4435-4443
Published Date: 27 October 2021
The Effects of Primary Unconjugated Bile Acids on Nanoencapsulated Pharmaceutical Formulation of Hydrophilic Drugs: Pharmacological Implications
Mooranian A, Foster T, Ionescu CM, Carey L, Walker D, Jones M, Wagle SR, Kovacevic B, Chester J, Johnstone E, Kuthubutheen J, Brown D, Atlas MD, Mikov M, Al-Salami H
Drug Design, Development and Therapy 2021, 15:4423-4434
Published Date: 23 October 2021
Mechanism of Yinqin Oral Liquid in the Treatment of Chronic Pharyngitis Based on Network Pharmacology
Ji S, Xu F, Zhu R, Wang C, Guo D, Jiang Y
Drug Design, Development and Therapy 2021, 15:4413-4421
Published Date: 20 October 2021
Unravelling the Protective Effects of Emodin Against Cyclophosphamide Induced Gonadotoxicity in Male Wistar Rats
Wang Y, Zou Z, Jaisi A, Olatunji OJ
Drug Design, Development and Therapy 2021, 15:4403-4411
Published Date: 19 October 2021
Formulation and Evaluation of Baclofen-Meloxicam Orally Disintegrating Tablets (ODTs) Using Co-Processed Excipients and Improvement of ODTs Performance Using Six Sigma Method
Abdelmonem R, Abdellatif MM, Al-Samadi IEI, El-Nabarawi MA
Drug Design, Development and Therapy 2021, 15:4383-4402
Published Date: 16 October 2021
The Steady-State Comparative Bioavailability of Intramuscular Risperidone ISM and Oral Risperidone: An Open-Label, One-Sequence Study
Walling DP, Hassman HA, Anta L, Ochoa L, Ayani I, Martínez J, Gutierro I
Drug Design, Development and Therapy 2021, 15:4371-4382
Published Date: 15 October 2021
Translational Regulation in Hepatocellular Carcinogenesis
Bracic Tomazic S, Schatz C, Haybaeck J
Drug Design, Development and Therapy 2021, 15:4359-4369
Published Date: 14 October 2021
Maackiain Protects the Kidneys of Type 2 Diabetic Rats via Modulating the Nrf2/HO-1 and TLR4/NF-κB/Caspase-3 Pathways
Guo J, Li J, Wei H, Liang Z
Drug Design, Development and Therapy 2021, 15:4339-4358
Published Date: 14 October 2021
The Expanding Role of Pyridine and Dihydropyridine Scaffolds in Drug Design
Ling Y, Hao ZY, Liang D, Zhang CL, Liu YF, Wang Y
Drug Design, Development and Therapy 2021, 15:4289-4338
Published Date: 13 October 2021
Triptolide is a Promising Therapeutic Approach in Treating Thyroid Cancer Based on in silico and in vitro Experiment
Wang F, An SJ, Yin Y, Li JJ, Sun CH, Lan J, Zhao WJ, Li CQ
Drug Design, Development and Therapy 2021, 15:4275-4287
Published Date: 11 October 2021
Investigation of the Active Ingredients and Mechanism of Hudi Enteric-Coated Capsules in DSS-Induced Ulcerative Colitis Mice Based on Network Pharmacology and Experimental Verification
Ding P, Liu J, Li Q, Lu Q, Li J, Shi R, Shi L, Mao T, Ge D, Niu H, Peng G, Wang Z
Drug Design, Development and Therapy 2021, 15:4259-4273
Published Date: 8 October 2021
Synthesis of Novel Pinocembrin Amino Acid Derivatives and Their Antiaging Effect on Caenorhabditis elegans via the Modulating DAF-16/FOXO [Corrigendum]
Wang W, Feng X, Du Y, Liu C, Pang X, Jiang K, Wang X, Liu Y
Drug Design, Development and Therapy 2021, 15:4257-4258
Published Date: 11 October 2021
The Therapeutic Effects of Curcumin in Early Septic Acute Kidney Injury: An Experimental Study
Wang S, Zhao P, Zhang Y, Zhu L, Zhu J, Luo Y, Li Q
Drug Design, Development and Therapy 2021, 15:4243-4255
Published Date: 7 October 2021
A Promising Single Oral Disintegrating Tablet for Co-Delivery of Pitavastatin Calcium and Lornoxicam Using Co-Processed Excipients: Formulation, Characterization and Pharmacokinetic Study
Teaima MH, Abdel-Haleem KM, Osama R, El-Nabarawi MA, Elnahas OS
Drug Design, Development and Therapy 2021, 15:4229-4242
Published Date: 7 October 2021
Saroglitazar – A Potential Therapeutic Option in Treating NASH? [Letter]
Shuja SH, Eqbal F, Rehman H
Drug Design, Development and Therapy 2021, 15:4227-4228
Published Date: 8 October 2021
Development and Characterization of Ulvan Polysaccharides-Based Hydrogel Films for Potential Wound Dressing Applications
Sulastri E, Zubair MS, Lesmana R, Mohammed AFA, Wathoni N
Drug Design, Development and Therapy 2021, 15:4213-4226
Published Date: 5 October 2021
Novel Anti-Tubulin Compounds from Trigonella foenum-graecum Seeds; Insights into In-vitro and Molecular Docking Studies
Alghamdi SS, Suliman RS, Alsaeed AS, Almutairi KK, Aljammaz NA, Altolayyan A, Ali R, Alhallaj A
Drug Design, Development and Therapy 2021, 15:4195-4211
Published Date: 5 October 2021
Synthesis of Novel Pinocembrin Amino Acid Derivatives and Their Antiaging Effect on Caenorhabditis elegans via the Modulating DAF-16/FOXO
Wang W, Feng X, Du Y, Liu C, Pang X, Jiang K, Wang X, Liu Y
Drug Design, Development and Therapy 2021, 15:4177-4193
Published Date: 5 October 2021
Development of an UPLC-MS/MS Method for the Quantitative Analysis of Upadacitinib in Beagle Dog Plasma and Pharmacokinetics Study
Wang MJ, Zhao YH, Fan C, Wang YJ, Wang XQ, Qiu XJ, Shen RL
Drug Design, Development and Therapy 2021, 15:4167-4175
Published Date: 2 October 2021
The Role of Pretreatment 18F-FDG PET/CT for Early Prediction of Neoadjuvant Chemotherapy Response in Patients with Locoregionally Advanced Nasopharyngeal Carcinoma
Yao J, Wang Y, Lin Y, Yang Y, Wan J, Gong X, Zhang F, Zhang W, Marks T, Wang S, Jin H, Shan H
Drug Design, Development and Therapy 2021, 15:4157-4166
Published Date: 1 October 2021
Transcriptome-Based Analysis Reveals Therapeutic Effects of Resveratrol on Endometriosis in aRat Model
Wang C, Chen Z, Zhao X, Lin C, Hong S, Lou Y, Shi X, Zhao M, Yang X, Guan MX, Xi Y
Drug Design, Development and Therapy 2021, 15:4141-4155
Published Date: 29 September 2021
Identification of Active Compounds and Mechanism of Huangtu Decoction for the Treatment of Ulcerative Colitis by Network Pharmacology Combined with Experimental Verification
Chen W, He L, Zhong L, Sun J, Zhang L, Wei D, Wu C
Drug Design, Development and Therapy 2021, 15:4125-4140
Published Date: 29 September 2021
Orally Deliverable Dual-Targeted Pellets for the Synergistic Treatment of Ulcerative Colitis
Tang X, Yang M, Gu Y, Jiang L, Du Y, Liu J
Drug Design, Development and Therapy 2021, 15:4105-4123
Published Date: 29 September 2021
Topical Lidocaine for Chronic Pain Treatment
Voute M, Morel V, Pickering G
Drug Design, Development and Therapy 2021, 15:4091-4103
Published Date: 29 September 2021
Evolution of Drug Delivery Systems for Recurrent Aphthous Stomatitis
Suharyani I, Fouad Abdelwahab Mohammed A, Muchtaridi M, Wathoni N, Abdassah M
Drug Design, Development and Therapy 2021, 15:4071-4089
Published Date: 27 September 2021
The Synergistic Effects of Astragalus mongholicus and Salvia miltiorrhiza on Coronary Heart Disease Identified by Network Pharmacology and Experiment
Zhang Y, Wang J, Liu YM, Chen YY, Yang XC, Duan L
Drug Design, Development and Therapy 2021, 15:4053-4069
Published Date: 27 September 2021
Synergistic Dose Permutation of Isolated Alkaloid and Sterol for Anticancer Effect on Young Swiss Albino Mice
Aljarba NH, Ali H, Alkahtani S
Drug Design, Development and Therapy 2021, 15:4043-4052
Published Date: 23 September 2021
Antioxidant, Anti-Aging and Organ Protective Effects of Total Saponins from Aralia taibaiensis
Li H, Zhai B, Sun J, Fan Y, Zou J, Cheng J, Zhang X, Shi Y, Guo D
Drug Design, Development and Therapy 2021, 15:4025-4042
Published Date: 23 September 2021
A Network Pharmacology Study on the Molecular Mechanism of Protocatechualdehyde in the Treatment of Diabetic Cataract
Cheng X, Song Z, Wang X, Xu S, Dong L, Bai J, Li G, Zhang C
Drug Design, Development and Therapy 2021, 15:4011-4023
Published Date: 23 September 2021
Non-Alcoholic Steatohepatitis (NASH) – A Review of a Crowded Clinical Landscape, Driven by a Complex Disease
Fraile JM, Palliyil S, Barelle C, Porter AJ, Kovaleva M
Drug Design, Development and Therapy 2021, 15:3997-4009
Published Date: 22 September 2021
Selection of DNA Aptamers Recognizing EpCAM-Positive Prostate Cancer by Cell-SELEX for in vitro and in vivo MR Imaging
Zhong J, Ding J, Deng L, Xiang Y, Liu D, Zhang Y, Chen X, Yang Q
Drug Design, Development and Therapy 2021, 15:3985-3996
Published Date: 21 September 2021
Stability of Amoxicillin and Clavulanic Acid in Separate Containers for Administration via a Y-Site
Fawaz S, Merzouk M, Barton S, Nabhani-Gebara S
Drug Design, Development and Therapy 2021, 15:3979-3984
Published Date: 21 September 2021
Ketamine Induces Ferroptosis of Liver Cancer Cells by Targeting lncRNA PVT1/miR-214-3p/GPX4
He GN, Bao NR, Wang S, Xi M, Zhang TH, Chen FS
Drug Design, Development and Therapy 2021, 15:3965-3978
Published Date: 18 September 2021
CpG Oligodeoxynucleotide Developed to Activate Primate Immune Responses Promotes Antitumoral Effects in Combination with a Neoantigen-Based mRNA Cancer Vaccine
Li Q, Ren J, Liu W, Jiang G, Hu R
Drug Design, Development and Therapy 2021, 15:3953-3963
Published Date: 18 September 2021
Gellan Gum-Based Bilayer Mucoadhesive Films Loaded with Moxifloxacin Hydrochloride and Clove Oil for Possible Treatment of Periodontitis
Li A, Khan IN, Khan IU, Yousaf AM, Shahzad Y
Drug Design, Development and Therapy 2021, 15:3937-3952
Published Date: 16 September 2021
Umbilical Cord Mesenchymal Stem Cell Therapy for Regenerative Treatment of Rheumatoid Arthritis: Opportunities and Challenges
Lv X, Wang L, Zou X, Huang S
Drug Design, Development and Therapy 2021, 15:3927-3936
Published Date: 15 September 2021
LC–MS/MS Estimation of Rociletinib Levels in Human Liver Microsomes: Application to Metabolic Stability Estimation
Attwa MW, Abdelhameed AS, Kadi AA
Drug Design, Development and Therapy 2021, 15:3915-3925
Published Date: 15 September 2021
Modeling and Simulation for Individualized Therapy of Amisulpride in Chinese Patients with Schizophrenia: Focus on Interindividual Variability, Therapeutic Reference Range and the Laboratory Alert Level
Huang S, Li L, Wang Z, Xiao T, Li X, Liu S, Zhang M, Lu H, Wen Y, Shang D
Drug Design, Development and Therapy 2021, 15:3903-3913
Published Date: 14 September 2021
Sugammadex, the Guardian of Deep Muscle Relaxation During Conventional and Robot-Assisted Laparoscopic Surgery: A Narrative Review
Sun Y, Wu Z, Wang Q, Chen R, Sun S, Lin Y
Drug Design, Development and Therapy 2021, 15:3893-3901
Published Date: 14 September 2021
Recent Advances of Microfluidic Platforms for Controlled Drug Delivery in Nanomedicine
Ejeta F
Drug Design, Development and Therapy 2021, 15:3881-3891
Published Date: 10 September 2021
The Anticancer Potential of Maslinic Acid and Its Derivatives: A Review
Yu L, Xie X, Cao X, Chen J, Chen G, Chen Y, Li G, Qin J, Peng F, Peng C
Drug Design, Development and Therapy 2021, 15:3863-3879
Published Date: 9 September 2021
The Jieduan-Niwan (JDNW) Formula Ameliorates Hepatocyte Apoptosis: A Study of the Inhibition of E2F1-Mediated Apoptosis Signaling Pathways in Acute-on-Chronic Liver Failure (ACLF) Using Rats
Hou W, Hao Y, Yang W, Tian T, Fang P, Du Y, Gao L, Gao Y, Zhang Q
Drug Design, Development and Therapy 2021, 15:3845-3862
Published Date: 8 September 2021
In vitro Comparison of Pancreatic Enzyme Preparations Available in the Indian Market
Shrikhande SV, Prasad VGM, Domínguez-Muñoz JE, Weigl KE, Sarda KD
Drug Design, Development and Therapy 2021, 15:3835-3843
Published Date: 7 September 2021
Resveratrol Pretreatment Inhibits Myocardial Apoptosis in Rats Following Coronary Microembolization via Inducing the PI3K/Akt/GSK-3β Signaling Cascade
Li T, Chen Z, Zhou Y, Li H, Xie J, Li L
Drug Design, Development and Therapy 2021, 15:3821-3834
Published Date: 7 September 2021
An Overview of Lenalidomide in Combination with Rituximab for the Treatment of Adult Patients with Follicular Lymphoma: The Evidence to Date
Yilmaz U, Salihoglu A, Soysal T
Drug Design, Development and Therapy 2021, 15:3809-3820
Published Date: 7 September 2021
An Integrated Analysis of Network Pharmacology and Experimental Validation to Reveal the Mechanism of Chinese Medicine Formula Naotaifang in Treating Cerebral Ischemia-Reperfusion Injury
Yang T, Chen X, Mei Z, Liu X, Feng Z, Liao J, Deng Y, Ge J
Drug Design, Development and Therapy 2021, 15:3783-3808
Published Date: 7 September 2021
Pore-Forming Toxins During Bacterial Infection: Molecular Mechanisms and Potential Therapeutic Targets
Hu H, Liu M, Sun S
Drug Design, Development and Therapy 2021, 15:3773-3781
Published Date: 7 September 2021
Determination of the 90% Effective Dose of Phenylephrine Boluses to Treat Spinal Anesthesia-Induced Hypotension in Patients with Severe Preeclampsia during Cesarean Delivery: A Pilot Study
Liu JP, Pan ZB, Zhu M, Zhu GW, Song DB, Chen XZ, Qian XW
Drug Design, Development and Therapy 2021, 15:3765-3772
Published Date: 7 September 2021
Integrating Network Pharmacology and Experimental Verification to Explore the Mechanism of Effect of Zuojin Pills in Pancreatic Cancer Treatment
Wang K, Miao X, Kong F, Huang S, Mo J, Jin C, Zheng Y
Drug Design, Development and Therapy 2021, 15:3749-3764
Published Date: 4 September 2021
Bardoxolone-Methyl Prevents Oxidative Stress-Mediated Apoptosis and Extracellular Matrix Degradation in vitro and Alleviates Osteoarthritis in vivo
Pang Z, Jiang Z, Zhu R, Song C, Tang H, Cao L, Guo C
Drug Design, Development and Therapy 2021, 15:3735-3747
Published Date: 4 September 2021
A Novel Bispecific Immunotoxin Delivered by Human Bone Marrow-Derived Mesenchymal Stem Cells to Target Blood Vessels and Vasculogenic Mimicry of Malignant Gliomas [Retraction]
Zhang Y, Sun X, Huang M, Ke Y, Wang J, Liu X
Drug Design, Development and Therapy 2021, 15:3733-3734
Published Date: 2 September 2021
The Legislative Approach and System Improvement of China’s Compulsory Licensing for Drug Patents
Cao Z, Chen Y, Jiang W, Li W
Drug Design, Development and Therapy 2021, 15:3717-3731
Published Date: 1 September 2021
Retrospective Study of the Effects of Zoledronic Acid on Muscle Mass in Osteoporosis Patients
Huang CF, Shiao MS, Mao TY
Drug Design, Development and Therapy 2021, 15:3711-3715
Published Date: 27 August 2021
Role of Folate, Cobalamin, and Probiotics in COVID-19 Disease Management [Letter]
Asad D, Shuja SH
Drug Design, Development and Therapy 2021, 15:3709-3710
Published Date: 25 August 2021
Puerarin Alleviates UUO-Induced Inflammation and Fibrosis by Regulating the NF-κB P65/STAT3 and TGFβ1/Smads Signaling Pathways
Wang J, Ge S, Wang Y, Liu Y, Qiu L, Li J, Huang X, Sun L
Drug Design, Development and Therapy 2021, 15:3697-3708
Published Date: 24 August 2021
Oleanolic Acid Attenuates Morphine Withdrawal Symptoms in Rodents: Association with Regulation of Dopamine Function
Shi Z, Pan S, Wang L, Li S
Drug Design, Development and Therapy 2021, 15:3685-3696
Published Date: 24 August 2021
Multivariate Assessment for Bioequivalence Based on the Correlation of Random Effect
An H, Shin D
Drug Design, Development and Therapy 2021, 15:3675-3683
Published Date: 23 August 2021
Effects of Avitinib on CYP450 Enzyme Activity in vitro and in vivo in Rats
Shi Y, Meng D, Wang S, Geng P, Xu T, Zhou Q, Zhou Y, Li W, Chen X
Drug Design, Development and Therapy 2021, 15:3661-3673
Published Date: 21 August 2021
Doxazosin Attenuates Liver Fibrosis by Inhibiting Autophagy in Hepatic Stellate Cells via Activation of the PI3K/Akt/mTOR Signaling Pathway
Xiu AY, Ding Q, Li Z, Zhang CQ
Drug Design, Development and Therapy 2021, 15:3643-3659
Published Date: 21 August 2021
Icariin, an Up-and-Coming Bioactive Compound Against Neurological Diseases: Network Pharmacology-Based Study and Literature Review
Wang S, Ma J, Zeng Y, Zhou G, Wang Y, Zhou W, Sun X, Wu M
Drug Design, Development and Therapy 2021, 15:3619-3641
Published Date: 20 August 2021
Hydroxyapatite Nanoparticles Facilitate Osteoblast Differentiation and Bone Formation Within Sagittal Suture During Expansion in Rats [Corrigendum]
Liang W, Ding P, Li G, Lu E, Zhao Z
Drug Design, Development and Therapy 2021, 15:3617-3618
Published Date: 20 August 2021
Combination Therapy of Metastatic Castration-Recurrent Prostate Cancer: Hyaluronic Acid Decorated, Cabazitaxel-Prodrug and Orlistat Co-Loaded Nano-System
Qu Z, Ren Y, Shen H, Wang H, Shi L, Tong D
Drug Design, Development and Therapy 2021, 15:3605-3616
Published Date: 20 August 2021
Bi-aryl Analogues of Salicylic Acids: Design, Synthesis and SAR Study to Ameliorate Endoplasmic Reticulum Stress
Kim YE, Kim DH, Choi A, Jang S, Jeong K, Kim YM, Nam TG
Drug Design, Development and Therapy 2021, 15:3593-3604
Published Date: 17 August 2021
Gene Therapy for Rdh12-Associated Retinal Diseases Helps to Delay Retinal Degeneration and Vision Loss
Bian J, Chen H, Sun J, Cao Y, An J, Pan Q, Qi M
Drug Design, Development and Therapy 2021, 15:3581-3591
Published Date: 17 August 2021
The Clinical Efficacy of Three Different Follicle-Stimulating Hormones for Follicle Growth and Development in Long-Protocol Controlled Ovarian Hyperstimulation Treatment
Zhang XQ, Zhang LJ, Zhu XL, Xu H, Luo YQ, Yao L, Huang QW, Nong YQ, Liu WJ, Liu FH
Drug Design, Development and Therapy 2021, 15:3573-3580
Published Date: 16 August 2021
Prompt Agalsidase Alfa Therapy Initiation is Associated with Improved Renal and Cardiovascular Outcomes in a Fabry Outcome Survey Analysis
Hughes D, Linhart A, Gurevich A, Kalampoki V, Jazukeviciene D, Feriozzi S
Drug Design, Development and Therapy 2021, 15:3561-3572
Published Date: 16 August 2021
The Synergistic Effect of Ginkgo biloba Extract 50 and Aspirin Against Platelet Aggregation
Ke J, Li MT, Huo YJ, Cheng YQ, Guo SF, Wu Y, Zhang L, Ma J, Liu AJ, Han Y
Drug Design, Development and Therapy 2021, 15:3543-3560
Published Date: 14 August 2021
Lower Background Infusion of Oxycodone for Patient-Controlled Intravenous Analgesia, Combined with Ropivacaine Intercostal Nerve Block, in Patients Undergoing Thoracoscopic Lobectomy for Lung Cancer: A Randomized, Double-Blind, Controlled Clinical Trial
Zhang Y, Yan W, Chen Y, Fan Z, Chen J
Drug Design, Development and Therapy 2021, 15:3535-3542
Published Date: 13 August 2021
Effectiveness and Anticancer Activity of a Novel Phenolic Compound from Garcinia porrecta Against the MCF-7 Breast Cancer Cell Line in vitro and in silico
Darwati D, Safitri AN, Ambardhani N, Mayanti T, Nurlelasari N, Kurnia D
Drug Design, Development and Therapy 2021, 15:3523-3533
Published Date: 12 August 2021
Quercetin Prevents Oxidative Stress-Induced Injury of Periodontal Ligament Cells and Alveolar Bone Loss in Periodontitis
Wei Y, Fu J, Wu W, Ma P, Ren L, Yi Z, Wu J
Drug Design, Development and Therapy 2021, 15:3509-3522
Published Date: 12 August 2021
The Reproductive Toxicity of Monosodium Glutamate by Damaging GnRH Neurons Cannot Be Relieved Spontaneously Over Time
Wang CX, Zhang Y, Li QF, Sun HL, Chong HL, Jiang JX, Li QC
Drug Design, Development and Therapy 2021, 15:3499-3508
Published Date: 12 August 2021
Efficacy, Pharmacokinetics, Biodistribution and Excretion of a Novel Acylated Long-Acting Insulin Analogue INS061 in Rats
Pan K, Shi X, Liu K, Wang J, Chen Y
Drug Design, Development and Therapy 2021, 15:3487-3498
Published Date: 10 August 2021
Transferrin-Decorated Protein-Lipid Hybrid Nanoparticle Efficiently Delivers Cisplatin and Docetaxel for Targeted Lung Cancer Treatment
Mao K, Zhang W, Yu L, Yu Y, Liu H, Zhang X
Drug Design, Development and Therapy 2021, 15:3475-3486
Published Date: 10 August 2021
Establishment of Prognostic Nomograms for Predicting the Survival of HR-Positive, HER2-Negative Metastatic Breast Cancer Patients Treated with Everolimus
Duan F, Song C, Ma Y, Jiang K, Xu F, Bi X, Huang J, Hong R, Huang Z, Lu Q, Yuan Z, Wang S, Xia W
Drug Design, Development and Therapy 2021, 15:3463-3473
Published Date: 10 August 2021
Ecust004 Suppresses Breast Cancer Cell Growth, Invasion, and Migration via EMT Regulation
Liu Z, Huang L, Sun L, Nie H, Liang Y, Huang J, Wu F, Hu X
Drug Design, Development and Therapy 2021, 15:3451-3461
Published Date: 10 August 2021
Hearing Protection Outcomes of Analog Electrode Arrays Coated with Different Drug-Eluting Polymer Films Implanted into Guinea Pig Cochleae
Huang Y, Yu H, Liang M, Hou S, Chen JM, Zhang F, Sun X, Jia H, Yang J
Drug Design, Development and Therapy 2021, 15:3443-3450
Published Date: 11 August 2021
Network Pharmacology and Experimental Evidence: PI3K/AKT Signaling Pathway is Involved in the Antidepressive Roles of Chaihu Shugan San
Zhang S, Lu Y, Chen W, Shi W, Zhao Q, Zhao J, Li L
Drug Design, Development and Therapy 2021, 15:3425-3441
Published Date: 5 August 2021
What to Do About Missed Doses? A Retrospective Study of Olanzapine in the Elderly
Xiao T, Wang Z, Li G, Huang S, Zhu X, Liu S, Li X, Hu J, Shang D, Wen Y
Drug Design, Development and Therapy 2021, 15:3411-3423
Published Date: 4 August 2021
Evidence and Current Use of Levosimendan in the Treatment of Heart Failure: Filling the Gap
Conti N, Gatti M, Raschi E, Diemberger I, Potena L
Drug Design, Development and Therapy 2021, 15:3391-3409
Published Date: 4 August 2021
Effect of Intravenous Lidocaine on Serum Interleukin-17 After Video-Assisted Thoracic Surgery for Non-Small-Cell Lung Cancer: A Randomized, Double-Blind, Placebo-Controlled Trial
Hou YH, Shi WC, Cai S, Liu H, Zheng Z, Qi FW, Li C, Feng XM, Peng K, Ji FH
Drug Design, Development and Therapy 2021, 15:3379-3390
Published Date: 3 August 2021
Real-World Use of Dalbavancin in the Era of Empowerment of Outpatient Antimicrobial Treatment: A Careful Appraisal Beyond Approved Indications Focusing on Unmet Clinical Needs
Gatti M, Andreoni M, Pea F, Viale P
Drug Design, Development and Therapy 2021, 15:3349-3378
Published Date: 3 August 2021
Hydroxyapatite Nanoparticles Facilitate Osteoblast Differentiation and Bone Formation Within Sagittal Suture During Expansion in Rats [Corrigendum]
Liang W, Ding P, Li G, Lu E, Zhao Z
Drug Design, Development and Therapy 2021, 15:3347-3348
Published Date: 2 August 2021
Qilin Pill Exerts Therapeutic Effect on Resection-Induced Premature Ovarian Insufficiency Rats by Inhibiting the MAPK and PI3K-AKT Signaling Pathways
Li D, Jia Y, Hou Y, Chen D, Zheng C, Chen L, Zhou L, Sun Z
Drug Design, Development and Therapy 2021, 15:3331-3345
Published Date: 30 July 2021
COVID-19: Vaccine Delivery System, Drug Repurposing and Application of Molecular Modeling Approach
Abd El Hadi SR, Zien El-Deen EE, Bahaa MM, Sadakah AA, Yassin HA
Drug Design, Development and Therapy 2021, 15:3313-3330
Published Date: 30 July 2021
Imidazole as a Promising Medicinal Scaffold: Current Status and Future Direction
Alghamdi SS, Suliman RS, Almutairi K, Kahtani K, Aljatli D
Drug Design, Development and Therapy 2021, 15:3289-3312
Published Date: 29 July 2021
Bioequivalence and Pharmacokinetic Evaluation of Two Oral Formulations of Regorafenib: An Open-Label, Randomised, Single-Dose, Two-Period, Two-Way Crossover Clinical Trial in Healthy Chinese Volunteers Under Fasting and Fed Conditions
Zhang Q, Wang Z, Wu J, Zhou Z, Zhou R, Hu W
Drug Design, Development and Therapy 2021, 15:3277-3288
Published Date: 29 July 2021
Network Pharmacology Prediction and Molecular Docking-Based Strategy to Discover the Potential Pharmacological Mechanism of Huai Hua San Against Ulcerative Colitis
Liu J, Liu J, Tong X, Peng W, Wei S, Sun T, Wang Y, Zhang B, Li W
Drug Design, Development and Therapy 2021, 15:3255-3276
Published Date: 28 July 2021
Effect of Berberine on Hyperuricemia and Kidney Injury: A Network Pharmacology Analysis and Experimental Validation in a Mouse Model
Li Q, Huang Z, Liu D, Zheng J, Xie J, Chen J, Zeng H, Su Z, Li Y
Drug Design, Development and Therapy 2021, 15:3241-3254
Published Date: 27 July 2021
Dual-Functional Peptide Driven Liposome Codelivery System for Efficient Treatment of Doxorubicin-Resistant Breast Cancer
Ahmed KS, Liu S, Mao J, Zhang J, Qiu L
Drug Design, Development and Therapy 2021, 15:3223-3239
Published Date: 27 July 2021
Baicalin Alleviates Oxidative Stress and Inflammation in Diabetic Nephropathy via Nrf2 and MAPK Signaling Pathway
Ma L, Wu F, Shao Q, Chen G, Xu L, Lu F
Drug Design, Development and Therapy 2021, 15:3207-3221
Published Date: 21 July 2021
A Network Pharmacology-Based Investigation to the Pharmacodynamic Material Basis and Mechanisms of the Anti-Inflammatory and Anti-Viral Effect of Isatis indigotica
Deng J, Ma Y, He Y, Yang H, Chen Y, Wang L, Huang D, Qiu S, Tao X, Chen W
Drug Design, Development and Therapy 2021, 15:3193-3206
Published Date: 20 July 2021
Analysis of Clinical Trials of New Drugs for Liver Diseases in China
Lin L, Li H
Drug Design, Development and Therapy 2021, 15:3181-3191
Published Date: 20 July 2021
Baicalin Rescues Cognitive Dysfunction, Mitigates Neurodegeneration, and Exerts Anti-Epileptic Effects Through Activating TLR4/MYD88/Caspase-3 Pathway in Rats
Yang J, Jia Z, Xiao Z, Zhao J, Lu Y, Chu L, Shao H, Pei L, Zhang S, Chen Y
Drug Design, Development and Therapy 2021, 15:3163-3180
Published Date: 20 July 2021
RETRACTED ARTICLE: Evaluation of Natural Bioactive-Derived Punicalagin Niosomes in Skin-Aging Processes Accelerated by Oxidant and Ultraviolet Radiation
Mohamad EA, Aly AA, Khalaf AA, Ahmed MI, Kamel RM, Abdelnaby SM, Abdelzaher YH, Sedrak MG, Mousa SA
Drug Design, Development and Therapy 2021, 15:3151-3162
Published Date: 17 July 2021
Wogonin Alleviates Kidney Tubular Epithelial Injury in Diabetic Nephropathy by Inhibiting PI3K/Akt/NF-κB Signaling Pathways
Lei L, Zhao J, Liu XQ, Chen J, Qi XM, Xia LL, Wu YG
Drug Design, Development and Therapy 2021, 15:3131-3150
Published Date: 16 July 2021
Design, Synthesis, Characterization and in vivo Antidiabetic Activity Evaluation of Some Chalcone Derivatives
Welday Kahssay S, Hailu GS, Taye Desta K
Drug Design, Development and Therapy 2021, 15:3119-3129
Published Date: 17 July 2021
Qing-Luo-Yin Alleviated Monocytes/Macrophages-Mediated Inflammation in Rats with Adjuvant-Induced Arthritis by Disrupting Their Interaction with (Pre)-Adipocytes Through PPAR-γ Signaling
Wang R, Li DF, Hu YF, Liao Q, Jiang TT, Olatunji OJ, Yang K, Zuo J
Drug Design, Development and Therapy 2021, 15:3105-3118
Published Date: 16 July 2021
The Potential Use of Ceftazidime-Avibactam Against Carbapenem Resistant Klebsiella pneumoniae Clinical Isolates Harboring Different Carbapenemase Types in a Thai University Hospital
Nasomsong W, Nulsopapon P, Changpradub D, Pongchaidecha M, Pungcharoenkijkul S, Juntanawiwat P, Simsiriporn W, Santimaleeworagun W
Drug Design, Development and Therapy 2021, 15:3095-3104
Published Date: 16 July 2021
Starch Nanoparticles for Enhancement of Oral Bioavailability of a Newly Synthesized Thienopyrimidine Derivative with Anti-Proliferative Activity Against Pancreatic Cancer
Gardouh AR, Srag El-Din AS, Salem MSH, Moustafa Y, Gad S
Drug Design, Development and Therapy 2021, 15:3071-3093
Published Date: 16 July 2021
Profile of Ipragliflozin, an Oral SGLT-2 Inhibitor for the Treatment of Type 2 Diabetes: The Evidence to Date
Alkabbani W, Gamble JM
Drug Design, Development and Therapy 2021, 15:3057-3069
Published Date: 14 July 2021
In vitro Antimicrobial Activity of Fosfomycin, Rifampin, Vancomycin, Daptomycin Alone and in Combination Against Vancomycin-Resistant Enterococci
Tong J, Jiang Y, Xu H, Jin X, Zhang L, Ying S, Yu W, Qiu Y
Drug Design, Development and Therapy 2021, 15:3049-3055
Published Date: 12 July 2021
A Call to Action by the Italian Mesotherapy Society on Scientific Research
Mammucari M, Paolucci T, Russo D, Maggiori E, Di Marzo R, Migliore A, Massafra U, Ronconi G, Ferrara PE, Gori F, Bifarini B, Brauneis S, Vellucci R, Mediati RD, Violo B, Natoli S, Pediliggieri C, Di Campli C, Collina MC
Drug Design, Development and Therapy 2021, 15:3041-3047
Published Date: 12 July 2021
Effects of Exenatide on Coagulation and Platelet Aggregation in Patients with Type 2 Diabetes
Zhang Y, Chen R, Jia Y, Chen M, Shuai Z
Drug Design, Development and Therapy 2021, 15:3027-3040
Published Date: 12 July 2021
Review of Allopregnanolone Agonist Therapy for the Treatment of Depressive Disorders
Walkery A, Leader LD, Cooke E, VandenBerg A
Drug Design, Development and Therapy 2021, 15:3017-3026
Published Date: 9 July 2021
Total Flavone of Abelmoschus manihot Ameliorates Stress-Induced Microbial Alterations Drive Intestinal Barrier Injury in DSS Colitis
Wang R, Chen T, Wang Q, Yuan XM, Duan ZL, Feng ZY, Ding Y, Bu F, Shi GP, Chen YG
Drug Design, Development and Therapy 2021, 15:2999-3016
Published Date: 8 July 2021
An Update Review of Biosimilars of Adalimumab in Psoriasis – Bioequivalence and Interchangeability
Zhou X, Chen Z, Bi X
Drug Design, Development and Therapy 2021, 15:2987-2998
Published Date: 8 July 2021
Assessing Palatability of a New Amphetamine Extended-Release Tablet Formulation for the Treatment of ADHD
Pardo A, King TR, Rafla E, Kando JC
Drug Design, Development and Therapy 2021, 15:2979-2985
Published Date: 8 July 2021
Spotlight on Melphalan Flufenamide: An Up-and-Coming Therapy for the Treatment of Myeloma
Morabito F, Tripepi G, Martino EA, Vigna E, Mendicino F, Morabito L, Todoerti K, Al-Janazreh H, D’Arrigo G, Canale FA, Cutrona G, Neri A, Martino M, Gentile M
Drug Design, Development and Therapy 2021, 15:2969-2978
Published Date: 8 July 2021
Pharmacokinetic Study of Frovatriptan Succinate Tablet After Single and Multiple Oral Doses in Chinese Healthy Subjects
Zheng H, Xia Y, Qu S, Fan L, Zhang J, Ma Z, Chen Y, Fan H
Drug Design, Development and Therapy 2021, 15:2961-2968
Published Date: 7 July 2021
A Phase I Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of TPN171H, a Novel Phosphodiesterase Type 5 Inhibitor, in Healthy Subjects
Qian H, Chen Q, Liang L, Zou Y, Pu H, Xin L, Song R, Li T, Zhu H, Wang Y, Tian G, Shen J, Jiang H, Yu C, Wang Z, Jia J
Drug Design, Development and Therapy 2021, 15:2947-2959
Published Date: 6 July 2021
The Development of Disease-Modifying Therapies for Osteoarthritis (DMOADs): The Evidence to Date
Oo WM, Little C, Duong V, Hunter DJ
Drug Design, Development and Therapy 2021, 15:2921-2945
Published Date: 6 July 2021
Mechanism of Tetrandrine Against Endometrial Cancer Based on Network Pharmacology
Shang W, Zhang J, Song H, Zhu S, Zhang A, Hua Y, Han S, Fu Y
Drug Design, Development and Therapy 2021, 15:2907-2919
Published Date: 6 July 2021
Evaluation of Ceftazidime/Avibactam Administration in Enterobacteriaceae and Pseudomonas aeruginosa Bloodstream Infections by Monte Carlo Simulation
Dai Y, Chang W, Zhou X, Yu W, Huang C, Chen Y, Ma X, Lu H, Ji R, Ying C, Wang P, Liu Z, Yuan Q, Xiao Y
Drug Design, Development and Therapy 2021, 15:2899-2905
Published Date: 6 July 2021
Hepatoprotective Effects of Polysaccharide from Anoectochilus roxburghii (Wall.) Lindl. on Rat Liver Injury Induced by CCl4
Yu X, Huang L, You C, Huang L
Drug Design, Development and Therapy 2021, 15:2885-2897
Published Date: 6 July 2021
Superhydrophobic Surface for Enhancing the Bioavailability of Salbutamol Sulfate from Cross-Linked Microspheres: Formulation, Characterization, and in vivo Evaluation
Gaber D, Abdoun S, Alfuraihy A, Altasan B, Alsubaiyel A
Drug Design, Development and Therapy 2021, 15:2869-2884
Published Date: 2 July 2021
Pentamidine Inhibits Ovarian Cancer Cell Proliferation and Migration by Maintaining Stability of PTEN in vitro
Wu Y, Zhang Z, Kou Z
Drug Design, Development and Therapy 2021, 15:2857-2868
Published Date: 1 July 2021
A Novel Folic Acid Receptor-Targeted Drug Delivery System Based on Curcumin-Loaded β-Cyclodextrin Nanoparticles for Cancer Treatment
Hong W, Guo F, Yu N, Ying S, Lou B, Wu J, Gao Y, Ji X, Wang H, Li A, Wang G, Yang G
Drug Design, Development and Therapy 2021, 15:2843-2855
Published Date: 30 June 2021
Exploration of the Effect and Mechanism of Fructus Lycii, Rehmanniae Radix Praeparata, and Paeonia lactiflora in the Treatment of AMD Based on Network Pharmacology and in vitro Experimental Verification
Chen X, Zuo J, Hu T, Shi X, Zhu Y, Wu H, Xia Y, Shi W, Wei W
Drug Design, Development and Therapy 2021, 15:2831-2842
Published Date: 28 June 2021
Profiling Pretomanid as a Therapeutic Option for TB Infection: Evidence to Date
Stancil SL, Mirzayev F, Abdel-Rahman SM
Drug Design, Development and Therapy 2021, 15:2815-2830
Published Date: 28 June 2021
Comparison of Stimulated Cycles with Low Dose r-FSH versus Hormone Replacement Cycles for Endometrial Preparation Prior to Frozen-Thawed Embryo Transfer in Young Women with Polycystic Ovarian Syndrome: A Single-Center Retrospective Cohort Study from China
Li L, Gao DD, Zhang Y, Song JY, Sun ZG
Drug Design, Development and Therapy 2021, 15:2805-2813
Published Date: 28 June 2021
Network Pharmacology Analysis of the Mechanisms of Compound Herba Sarcandrae (Fufang Zhongjiefeng) Aerosol in Chronic Pharyngitis Treatment
Zhang Y, Yuan T, Li Y, Wu N, Dai X
Drug Design, Development and Therapy 2021, 15:2783-2803
Published Date: 28 June 2021
Study on the Inhibitory Effect of Curcumin on GBM and Its Potential Mechanism
Su X, Chen S, Lu H, Li H, Qin C
Drug Design, Development and Therapy 2021, 15:2769-2781
Published Date: 28 June 2021
Progress in Redirecting Antiparasitic Drugs for Cancer Treatment
Huang H, He Q, Guo B, Xu X, Wu Y, Li X
Drug Design, Development and Therapy 2021, 15:2747-2767
Published Date: 22 June 2021
Chemistry, Pharmacology and Therapeutic Potential of Swertiamarin – A Promising Natural Lead for New Drug Discovery and Development
Muhamad Fadzil NS, Sekar M, Gan SH, Bonam SR, Wu YS, Vaijanathappa J, Ravi S, Lum PT, Dhadde SB
Drug Design, Development and Therapy 2021, 15:2721-2746
Published Date: 21 June 2021
The Clinical Efficacy and Safety of Neratinib in Combination with Capecitabine for the Treatment of Adult Patients with Advanced or Metastatic HER2-Positive Breast Cancer
Chilà G, Guarini V, Galizia D, Geuna E, Montemurro F
Drug Design, Development and Therapy 2021, 15:2711-2720
Published Date: 21 June 2021
Nanoscale Formulations: Incorporating Curcumin into Combination Strategies for the Treatment of Lung Cancer
Wu Q, Ou H, Shang Y, Zhang X, Wu J, Fan F
Drug Design, Development and Therapy 2021, 15:2695-2709
Published Date: 21 June 2021
Prospective Application of Two New Pyridine-Based Zinc (II) Amide Carboxylate in Management of Alzheimer’s Disease: Synthesis, Characterization, Computational and in vitro Approaches
Zafar R, Naureen H, Zubair M, Shahid K, Saeed Jan M, Akhtar S, Ahmad H, Waseem W, Haider A, Ali S, Tariq M, Sadiq A
Drug Design, Development and Therapy 2021, 15:2679-2694
Published Date: 21 June 2021
A Highly Sensitive Nonextraction-Assisted HPLC Method with Fluorescence Detection for Quantification of Duvelisib in Plasma Samples and its Application to Pharmacokinetic Study in Rats
Sayed AY, Khalil NY, Almomen A, Alzoman NZ, Almehizia AA, Darwish IA
Drug Design, Development and Therapy 2021, 15:2667-2677
Published Date: 21 June 2021
Vascular Endothelial Growth Factor Antagonists: Promising Players in the Treatment of Neovascular Age-Related Macular Degeneration
Hussain RM, Shaukat BA, Ciulla LM, Berrocal AM, Sridhar J
Drug Design, Development and Therapy 2021, 15:2653-2665
Published Date: 21 June 2021
Curcumol Ameliorates Lung Inflammation and Airway Remodeling via Inhibiting the Abnormal Activation of the Wnt/β-Catenin Pathway in Chronic Asthmatic Mice
Jia S, Guo P, Lu J, Huang X, Deng L, Jin Y, Zhao L, Fan X
Drug Design, Development and Therapy 2021, 15:2641-2651
Published Date: 21 June 2021
Immunoregulatory Effect of Acanthopanax trifoliatus (L.) Merr. Polysaccharide on T1DM Mice
Li P, Chen Y, Luo L, Yang H, Pan Y
Drug Design, Development and Therapy 2021, 15:2629-2639
Published Date: 18 June 2021
The Agonists of Peroxisome Proliferator-Activated Receptor-γ for Liver Fibrosis
Li J, Guo C, Wu J
Drug Design, Development and Therapy 2021, 15:2619-2628
Published Date: 18 June 2021
Effect of a 2-HP-β-Cyclodextrin Formulation on the Biological Transport and Delivery of Chemotherapeutic PLGA Nanoparticles
Zheng K, Huang Z, Huang J, Liu X, Ban J, Huang X, Luo H, Chen Z, Xie Q, Chen Y, Lu Z
Drug Design, Development and Therapy 2021, 15:2605-2618
Published Date: 17 June 2021
Optimal Empiric Polymyxin B Treatment of Patients Infected with Gram-Negative Organisms Detected Using a Blood Antimicrobial Surveillance Network in China
Wu X, Huang C, Wang H, Ji J, Ying C, Xiao Y
Drug Design, Development and Therapy 2021, 15:2593-2603
Published Date: 17 June 2021
Synthesis, Radiolabeling, and Preliminary in vivo Evaluation of [68Ga] IPCAT-NOTA as an Imaging Agent for Dopamine Transporter
Farn SS, Chang KW, Lin WC, Yu HM, Lin KL, Tseng YC, Chang Y, Yu CS, Lin WJ
Drug Design, Development and Therapy 2021, 15:2577-2591
Published Date: 17 June 2021
Metformin in Combination with Malvidin Prevents Progression of Non-Alcoholic Fatty Liver Disease via Improving Lipid and Glucose Metabolisms, and Inhibiting Inflammation in Type 2 Diabetes Rats
Zou W, Zhang C, Gu X, Li X, Zhu H
Drug Design, Development and Therapy 2021, 15:2565-2576
Published Date: 17 June 2021
Sulfasalazine Inhibits Inflammation and Fibrogenesis in Pancreas via NF-κB Signaling Pathway in Rats with Oxidative Stress-Induced Pancreatic Injury [Corrigendum]
Wang Y, Tian F, Yan M, Fan J, Wang L, Kuang R, Li Y
Drug Design, Development and Therapy 2021, 15:2563-2564
Published Date: 16 June 2021
Bioequivalence Evaluation of Two Formulations of Tenofovir Alafenamide Tablets in Healthy Subjects Under Fasting and Fed Conditions
Li Q, Jia L, Hu W, Dong S, Cai C
Drug Design, Development and Therapy 2021, 15:2551-2562
Published Date: 16 June 2021
Estrogen and Preeclampsia: Potential of Estrogens as Therapeutic Agents in Preeclampsia
Shu C, Han S, Xu P, Wang Y, Cheng T, Hu C
Drug Design, Development and Therapy 2021, 15:2543-2550
Published Date: 15 June 2021
Simultaneous Determination of Celecoxib, Dezocine and Dexmedetomidine in Beagle Plasma Using UPLC-MS/MS Method and the Application in Pharmacokinetics
Hu J, Su XJ, Si HL, Song RX, Zhang F, Qiu XJ, Chen XP
Drug Design, Development and Therapy 2021, 15:2529-2541
Published Date: 15 June 2021
Stability of Aprepitant Injectable Emulsion in Alternate Infusion Bags, in Refrigerated Storage, and Admixed with Dexamethasone and Palonosetron
Ottoboni T, Lerner L, Santhouse A
Drug Design, Development and Therapy 2021, 15:2519-2527
Published Date: 15 June 2021
The Current Evidence for the Use of Safinamide for the Treatment of Parkinson’s Disease
Abbruzzese G, Barone P, Lopiano L, Stocchi F
Drug Design, Development and Therapy 2021, 15:2507-2517
Published Date: 10 June 2021
High-Impact Clinical Studies That Fomented New Developments in Anesthesia: History of Achievements, 1966–2015
Kissin I
Drug Design, Development and Therapy 2021, 15:2495-2505
Published Date: 11 June 2021
Multiple Administrations of Itraconazole Increase Plasma Exposure to Pyrotinib in Chinese Healthy Adults
Liu Y, Zhang Q, Lu C, Hu W
Drug Design, Development and Therapy 2021, 15:2485-2493
Published Date: 10 June 2021
Ursolic Acid Reduces the Metalloprotease/Anti-Metalloprotease Imbalance in Cerebral Ischemia and Reperfusion Injury [Corrigendum]
Wang Y, He Z, Deng S
Drug Design, Development and Therapy 2021, 15:2483-2484
Published Date: 11 June 2021
Factors Associated with Benzodiazepines Prolonged-Term Use in Post-Stroke Subjective Sleep Disturbance: A Single-Centre Retrospective Study from China
Ma G, Sun L, Qie Z, He J, Cui F
Drug Design, Development and Therapy 2021, 15:2469-2481
Published Date: 9 June 2021
Cytokine and Chemokine Profile Changes in Patients with Neovascular Age-Related Macular Degeneration After Intravitreal Ranibizumab Injection for Choroidal Neovascularization
Sun T, Wei Q, Gao P, Zhang Y, Peng Q
Drug Design, Development and Therapy 2021, 15:2457-2467
Published Date: 9 June 2021
Inhibitors Targeting YAP in Gastric Cancer: Current Status and Future Perspectives
Yong J, Li Y, Lin S, Wang Z, Xu Y
Drug Design, Development and Therapy 2021, 15:2445-2456
Published Date: 9 June 2021
High-Dose Dexmedetomidine Promotes Apoptosis in Fetal Rat Hippocampal Neurons
Wei Q, Chen J, Xiao F, Tu Y, Zhong Y, Xie Y
Drug Design, Development and Therapy 2021, 15:2433-2444
Published Date: 8 June 2021
Metformin Decreases Insulin Resistance in Type 1 Diabetes Through Regulating P53 and RAP2A in vitro and in vivo [Retraction]
Ren GF, Xiao LL, Ma XJ, Yan YS, Jiao PF
Drug Design, Development and Therapy 2021, 15:2431-2432
Published Date: 8 June 2021
Volumetric Absorptive Microsampling as a New Biosampling Tool for Monitoring of Tamoxifen, Endoxifen, 4-OH Tamoxifen and N-Desmethyltamoxifen in Breast Cancer Patients
Maggadani BP, Harmita, Haryono SJ, Rinaldi MR, Harahap Y
Drug Design, Development and Therapy 2021, 15:2417-2430
Published Date: 4 June 2021
Belantamab Mafodotin for the Treatment of Multiple Myeloma: An Overview of the Clinical Efficacy and Safety
Offidani M, Corvatta L, Morè S, Olivieri A
Drug Design, Development and Therapy 2021, 15:2401-2415
Published Date: 2 June 2021
Tetramethylpyrazine Improves Cognitive Function of Alzheimer’s Disease Mice by Regulating SSTR4 Ubiquitination
Weng G, Zhou B, Liu T, Huang Z, Huang S
Drug Design, Development and Therapy 2021, 15:2385-2399
Published Date: 1 June 2021
Pharmacokinetics, Tolerability and Pharmacogenetics of DA-8031 After Multiple Ascending Doses in Healthy Male Subjects
Hwang S, Lee DY, Cho JY, Chung JY, Jang IJ, Yu KS, Lee S
Drug Design, Development and Therapy 2021, 15:2375-2384
Published Date: 1 June 2021
Topical Delivery of Levocarnitine to the Cornea and Anterior Eye by Thermosensitive in-situ Gel for Dry Eye Disease
Ma B, Pang L, Huang P, Bai J, Zhang Z, Wu H, Cai M, Yang J, Xu Y, Yin X, Qu C, Ni J
Drug Design, Development and Therapy 2021, 15:2357-2373
Published Date: 2 June 2021
Cinnamaldehyde Improves Metabolic Functions in Streptozotocin-Induced Diabetic Mice by Regulating Gut Microbiota
Zhao H, Wu H, Duan M, Liu R, Zhu Q, Zhang K, Wang L
Drug Design, Development and Therapy 2021, 15:2339-2355
Published Date: 1 June 2021
Novel Phenolic Compounds as Potential Dual EGFR and COX-2 Inhibitors: Design, Semisynthesis, in vitro Biological Evaluation and in silico Insights
Abdelgawad MA, Musa A, Almalki AH, Alzarea SI, Mostafa EM, Hegazy MM, Mostafa-Hedeab G, Ghoneim MM, Parambi DGT, Bakr RB, Al-Muaikel NS, Alanazi AS, Alharbi M, Ahmad W, Bukhari SNA, Al-Sanea MM
Drug Design, Development and Therapy 2021, 15:2325-2337
Published Date: 31 May 2021
Selective Inhibition of 11β-Hydroxysteroid Dehydrogenase Type 1 Attenuates High-Fat Diet-Induced Hepatic Steatosis in Mice
Li H, Sheng J, Wang J, Gao H, Yu J, Ding G, Ding N, He W, Zha J
Drug Design, Development and Therapy 2021, 15:2309-2324
Published Date: 31 May 2021
Incidence and Risk Factors of Hepatic Fibrosis in Psoriatic Patients Receiving Methotrexate with Concomitant Acitretin Therapy and Methotrexate Monotherapy
Rattanakaemakorn P, Pinyowiwat P, Iamsumang W, Chanprapaph K, Suchonwanit P
Drug Design, Development and Therapy 2021, 15:2299-2307
Published Date: 28 May 2021
Effect of Dezocine on the Ratio of Th1/Th2 Cytokines in Patients Receiving Postoperative Analgesia Following Laparoscopic Radical Gastrectomy: A Prospective Randomised Study
Feng M, Feng Q, Chen Y, Liu G, Gao Z, Xiao J, Feng C
Drug Design, Development and Therapy 2021, 15:2289-2297
Published Date: 27 May 2021
Clinical Application of Cytokines in Cancer Immunotherapy
Qiu Y, Su M, Liu L, Tang Y, Pan Y, Sun J
Drug Design, Development and Therapy 2021, 15:2269-2287
Published Date: 27 May 2021
A Review of Romiplostim Mechanism of Action and Clinical Applicability
Bussel JB, Soff G, Balduzzi A, Cooper N, Lawrence T, Semple JW
Drug Design, Development and Therapy 2021, 15:2243-2268
Published Date: 26 May 2021
Total Glucosides of Paeony Inhibited Autophagy and Improved Acute Kidney Injury Induced by Ischemia-Reperfusion via the lncRNA TUG1/miR-29a/PTEN Axis
Chang X, Zhang P, Xu XX, Pang B
Drug Design, Development and Therapy 2021, 15:2229-2242
Published Date: 25 May 2021
Enhanced Accumulation of Cisplatin in Ovarian Cancer Cells from Combination with Wedelolactone and Resulting Inhibition of Multiple Epigenetic Drivers
Sarwar S, Alamro AA, Alghamdi AA, Naeem K, Ullah S, Arif M, Yu JQ, Huq F
Drug Design, Development and Therapy 2021, 15:2211-2227
Published Date: 25 May 2021
Fixed Dose Single Tablet Formulation with Differential Release of Amlodipine Besylate and Simvastatin and Its Pharmacokinetic Profile: QbD and Risk Assessment Approach
Kanwal U, Mukhtar S, Waheed M, Mehreen A, Abbas N, Shamim R, Hussain K, Rasool F, Hussain A, Bukhari NI
Drug Design, Development and Therapy 2021, 15:2193-2210
Published Date: 24 May 2021
Mechanism of Action of Nicotiflorin from Tricyrtis maculata in the Treatment of Acute Myocardial Infarction: From Network Pharmacology to Experimental Pharmacology
Yu S, Guo Q, Jia T, Zhang X, Guo D, Jia Y, Li J, Sun J
Drug Design, Development and Therapy 2021, 15:2179-2191
Published Date: 24 May 2021
Development of UPLC-MS/MS Method for Studying the Pharmacokinetic Interaction Between Dasatinib and Posaconazole in Rats
Yang S, Zhang X, Wang Y, Wen C, Wang C, Zhou Z, Lin G
Drug Design, Development and Therapy 2021, 15:2171-2178
Published Date: 24 May 2021
Effect of Dexmedetomidine on Postoperative Sleep Quality: A Systematic Review
Huang X, Lin D, Sun Y, Wu A, Wei C
Drug Design, Development and Therapy 2021, 15:2161-2170
Published Date: 21 May 2021
Toxicities and Associated Factors in Patients Receiving Temozolomide-Containing Regimens: A 12-Year Analysis of Hospital Data
Shi C, Wang X, Diao C, Zhu H, Yuan Q, Liu J, Li S, Gu M, Zhang Y
Drug Design, Development and Therapy 2021, 15:2151-2159
Published Date: 20 May 2021
Adjuvant Sufentanil Decreased the EC50 of Epidural Ropivacaine for Labor Analgesia in Healthy Term Pregnancy
Xiang B, Yang J, Lei X, Yu J
Drug Design, Development and Therapy 2021, 15:2143-2149
Published Date: 18 May 2021
Pharmacokinetics of Linezolid Dose Adjustment for Creatinine Clearance in Critically Ill Patients: A Multicenter, Prospective, Open-Label, Observational Study
Wang X, Wang Y, Yao F, Chen S, Hou Y, Zheng Z, Luo J, Qiu B, Li Z, Wang Y, Wu Z, Lan J, Chen C
Drug Design, Development and Therapy 2021, 15:2129-2141
Published Date: 19 May 2021
Canagliflozin Facilitates Reverse Cholesterol Transport Through Activation of AMPK/ABC Transporter Pathway
Zhao Y, Li Y, Liu Q, Tang Q, Zhang Z, Zhang J, Huang C, Huang H, Zhang G, Zhou J, Yan J, Xia Y, Zhang Z, He J
Drug Design, Development and Therapy 2021, 15:2117-2128
Published Date: 18 May 2021
The Abuse Characteristics of Amphetamine-Type Stimulants in Patients Receiving Methadone Maintenance Treatment and Buprenorphine Maintenance Treatment
Liu Y, Liu N, Shen W, Li L, Zhou W, Xu L
Drug Design, Development and Therapy 2021, 15:2109-2116
Published Date: 18 May 2021
In vivo and in vitro Evaluation of in situ Gel Formulation of Pemirolast Potassium in Allergic Conjunctivitis
Shen T, Yang Z
Drug Design, Development and Therapy 2021, 15:2099-2107
Published Date: 18 May 2021
Antifungal Efficacy and Safety of Cycloheximide as a Supplement in Optisol-GS
Dal Pizzol M, Freitas EC, Locatelli C, Guareze F, Reginatto P, Machado G, Fuentefria A, Marinho D
Drug Design, Development and Therapy 2021, 15:2091-2098
Published Date: 18 May 2021
An Integrated Analysis of Network Pharmacology, Molecular Docking, and Experiment Validation to Explore the New Candidate Active Component and Mechanism of Cuscutae Semen-Mori Fructus Coupled-Herbs in Treating Oligoasthenozoospermia
Bai X, Tang Y, Li Q, Liu D, Liu G, Fan X, Liu Z, Yu S, Tang T, Wang S, Li L, Zhou K, Zheng Y, Liu Z
Drug Design, Development and Therapy 2021, 15:2059-2089
Published Date: 17 May 2021
Protective Effect of Lemon Peel Extract on Oxidative Stress in H9c2 Rat Heart Cell Injury
Wang J, Zhai Y, Ou M, Bian Y, Tang C, Zhang W, Cheng Y, Li G
Drug Design, Development and Therapy 2021, 15:2047-2058
Published Date: 14 May 2021
Silver Nanoparticle-Coated Ethyl Cellulose Inhibits Tumor Necrosis Factor-α of Breast Cancer Cells
Abdellatif AAH, Alsharidah M, Al Rugaie O, Tawfeek HM, Tolba NS
Drug Design, Development and Therapy 2021, 15:2035-2046
Published Date: 13 May 2021
PTBP1 Targets ILK to Regulate the Hypoxia-Induced Phenotypic Transformation of Pulmonary Artery Smooth Muscle Cells
Yan G, Sun R, Chen Z, Pan X, Sheng Z, Tang C
Drug Design, Development and Therapy 2021, 15:2025-2033
Published Date: 13 May 2021
Epigallocatechin-3-Gallate Provides Protection Against Alzheimer’s Disease-Induced Learning and Memory Impairments in Rats
Nan S, Wang P, Zhang Y, Fan J
Drug Design, Development and Therapy 2021, 15:2013-2024
Published Date: 13 May 2021
Cariprazine as a Treatment Option for Depressive Episodes Associated with Bipolar 1 Disorder in Adults: An Evidence-Based Review of Recent Data
Tohen M
Drug Design, Development and Therapy 2021, 15:2005-2012
Published Date: 12 May 2021
An Overview of the Efficacy and Safety of Ozanimod for the Treatment of Relapsing Multiple Sclerosis
Fronza M, Lorefice L, Frau J, Cocco E
Drug Design, Development and Therapy 2021, 15:1993-2004
Published Date: 11 May 2021
FTY720 Inhibits the Development of Collagen-Induced Arthritis in Mice by Suppressing the Recruitment of CD4+ T Lymphocytes
Zhu C, Wen S, Li J, Meng H, Zhang J, Zhao K, Wang L, Zhang Y
Drug Design, Development and Therapy 2021, 15:1981-1992
Published Date: 11 May 2021
Inhibitory Effect of Lactococcus lactis subsp. lactis HFY14 on Diphenoxylate-Induced Constipation in Mice by Regulating the VIP-cAMP-PKA-AQP3 Signaling Pathway
Tan Q, Hu J, Zhou Y, Wan Y, Zhang C, Liu X, Long X, Tan F, Zhao X
Drug Design, Development and Therapy 2021, 15:1971-1980
Published Date: 11 May 2021
Evaluating Guanfacine Hydrochloride in the Treatment of Attention Deficit Hyperactivity Disorder (ADHD) in Adult Patients: Design, Development and Place in Therapy
Ota T, Yamamuro K, Okazaki K, Kishimoto T
Drug Design, Development and Therapy 2021, 15:1965-1969
Published Date: 11 May 2021
Bempedoic Acid for Heterozygous Familial Hypercholesterolemia: From Bench to Bedside
Agarwala A, Quispe R, Goldberg AC, Michos ED
Drug Design, Development and Therapy 2021, 15:1955-1963
Published Date: 10 May 2021
Consolidation Treatment and Long-Term Prognosis of Rituximab in Minimal Change Disease and Focal Segmental Glomerular Sclerosis
Lin L, Wang W, Wu Y, Xie J, Li X, Pan X, Zhang W, Xu J, Cai Y, Ren H, Chen N
Drug Design, Development and Therapy 2021, 15:1945-1953
Published Date: 10 May 2021
Body Mass Index Influence on the Clinical Outcomes for Nonvalvular Atrial Fibrillation Patients Admitted to a Hospital Treated with Direct Oral Anticoagulants: A Retrospective Cohort Study
Li X, Zuo C, Ji Q, Xue Y, Wang Z, Lv Q
Drug Design, Development and Therapy 2021, 15:1931-1943
Published Date: 6 May 2021
Potential Mechanism of S. baicalensis on Lipid Metabolism Explored via Network Pharmacology and Untargeted Lipidomics
Ge PY, Qi YY, Qu SY, Zhao X, Ni S, Yao ZY, Guo R, Yang NY, Zhang QC, Zhu HX
Drug Design, Development and Therapy 2021, 15:1915-1930
Published Date: 4 May 2021
Protective Effects of Silymarin Against D-Gal/LPS-Induced Organ Damage and Inflammation in Mice
Zhao X, Wang H, Yang Y, Gou Y, Wang Z, Yang D, Li C
Drug Design, Development and Therapy 2021, 15:1903-1914
Published Date: 4 May 2021
Study on Hepatotoxicity of Rhubarb Based on Metabolomics and Network Pharmacology
Li S, Wang Y, Li C, Yang N, Yu H, Zhou W, Chen S, Yang S, Li Y
Drug Design, Development and Therapy 2021, 15:1883-1902
Published Date: 4 May 2021
Camrelizumab Combined with FOLFOX4 Regimen as First-Line Therapy for Advanced Hepatocellular Carcinomas: A Sub-Cohort of a Multicenter Phase Ib/II Study
Li H, Qin S, Liu Y, Chen Z, Ren Z, Xiong J, Meng Z, Zhang X, Wang L, Zhang X, Zou J
Drug Design, Development and Therapy 2021, 15:1873-1882
Published Date: 3 May 2021
Effects of Systemic Lidocaine on Postoperative Recovery Quality and Immune Function in Patients Undergoing Laparoscopic Radical Gastrectomy
Lv X, Li X, Guo K, Li T, Yang Y, Lu W, Wang S, Liu S
Drug Design, Development and Therapy 2021, 15:1861-1872
Published Date: 3 May 2021
Forkhead Box Protein O1: Functional Diversity and Post-Translational Modification, a New Therapeutic Target?
Zhang X, Jiang L, Liu H
Drug Design, Development and Therapy 2021, 15:1851-1860
Published Date: 3 May 2021
Exosomal Circ-XIAP Promotes Docetaxel Resistance in Prostate Cancer by Regulating miR-1182/TPD52 Axis
Zhang H, Li M, Zhang J, Shen Y, Gui Q
Drug Design, Development and Therapy 2021, 15:1835-1849
Published Date: 3 May 2021
Thymoquinone: A Promising Natural Compound with Potential Benefits for COVID-19 Prevention and Cure
Badary OA, Hamza MS, Tikamdas R
Drug Design, Development and Therapy 2021, 15:1819-1833
Published Date: 3 May 2021
The Application of Zonisamide to Patients Suffering from Dementia with Lewy Bodies: Emerging Clinical Data
Tousi B, Leverenz JB
Drug Design, Development and Therapy 2021, 15:1811-1817
Published Date: 3 May 2021
OSU-03012 Disrupts Akt Signaling and Prevents Endometrial Carcinoma Progression in vitro and in vivo
Ding L, Ren C, Yang L, Wu Z, Li F, Jiang D, Zhu Y, Lu J
Drug Design, Development and Therapy 2021, 15:1797-1810
Published Date: 30 April 2021
Integrating Network Pharmacology and Experimental Validation to Decipher the Mechanism of Action of Huanglian Jiedu Decoction in Treating Atherosclerosis
Liang J, Huang Y, Mai Z, Zhan Q, Lin H, Xie Y, Wang H, Liu Y, Luo C
Drug Design, Development and Therapy 2021, 15:1779-1795
Published Date: 30 April 2021
Active-Ingredient Screening and Synergistic Action Mechanism of Shegan Mixture for Anti-Asthma Effects Based on Network Pharmacology in a Mouse Model of Asthma
Ye Q, Zhang Q, Yao H, Xu A, Liu Y, Qi J, Zhang H, Zhang J
Drug Design, Development and Therapy 2021, 15:1765-1777
Published Date: 29 April 2021
MYC/NBS1-Mediated DNA Damage Response is Involved in the Inhibitory Effect of Hydroxysafflor Yellow A on Glioma Cells
Tang D, Huang T, Tian Q, Wang J
Drug Design, Development and Therapy 2021, 15:1749-1763
Published Date: 28 April 2021
Comparison of Pharmacokinetic, Pharmacodynamic and Tolerability Profiles of CKD-11101, Darbepoetin Alfa (NESP®) Biosimilar, to Those of NESP® After a Single Subcutaneous or Intravenous Administration to Healthy Subjects
Jeon I, Oh J, Kwon YK, Yoon SH, Cho JY, Jang IJ, Yu KS, Lee S
Drug Design, Development and Therapy 2021, 15:1735-1747
Published Date: 28 April 2021
No Relevant Pharmacokinetic Drug–Drug Interaction Between the Sodium-Glucose Co-Transporter-2 Inhibitor Empagliflozin and Lobeglitazone, a Peroxisome Proliferator-Activated Receptor-γ Agonist, in Healthy Subjects
Kim YK, Hwang JG, Park MK
Drug Design, Development and Therapy 2021, 15:1725-1734
Published Date: 28 April 2021
Alendronate Alleviated Femoral Head Necrosis and Upregulated BMP2/EIF2AK3/EIF2A/ATF4 Pathway in Liquid Nitrogen Treated Rats
Rong K, Li X, Jiang W, Wu X, Xia Q, Chen J, Yin X
Drug Design, Development and Therapy 2021, 15:1717-1724
Published Date: 23 April 2021
Flavopereirine Suppresses the Progression of Human Oral Cancer by Inhibiting the JAK-STAT Signaling Pathway via Targeting LASP1
Xu J, Wu Z, Huang J
Drug Design, Development and Therapy 2021, 15:1705-1716
Published Date: 22 April 2021
Carbon Monoxide Releasing Molecule-3 Enhances Osteogenic Differentiation of Human Periodontal Ligament Stem Cells by Carbon Monoxide Release
Chen H, Dai Y, Cui J, Yin X, Feng W, lv M, Song H
Drug Design, Development and Therapy 2021, 15:1691-1704
Published Date: 22 April 2021
Rituximab Therapy for Treatment of Pemphigus in Southeast Asians
Kanokrungsee S, Anuntrangsee T, Tankunakorn J, Srisuwanwattana P, Suchonwanit P, Chanprapaph K
Drug Design, Development and Therapy 2021, 15:1677-1690
Published Date: 22 April 2021
Lactobacillus plantarum ZS62 Alleviates Alcohol-Induced Gastric Injury in Mice via an Anti-Oxidative Mechanism
Wu Y, Hu J, Long X, Pan Y, Mu J, Park KY, Zhao X
Drug Design, Development and Therapy 2021, 15:1667-1676
Published Date: 22 April 2021
Fasudil Dichloroacetate Alleviates SU5416/Hypoxia-Induced Pulmonary Arterial Hypertension by Ameliorating Dysfunction of Pulmonary Arterial Smooth Muscle Cells
Liu P, Huang W, Ding Y, Wu J, Liang Z, Huang Z, Xie W, Kong H
Drug Design, Development and Therapy 2021, 15:1653-1666
Published Date: 22 April 2021
Temozolomide-Induced Changes in Gut Microbial Composition in a Mouse Model of Brain Glioma
Li XC, Wu BS, Jiang Y, Li J, Wang ZF, Ma C, Li YR, Yao J, Jin XQ, Li ZQ
Drug Design, Development and Therapy 2021, 15:1641-1652
Published Date: 21 April 2021
Population Pharmacokinetics and Safety of Oral Tetra-Arsenic Tetra-Sulfide Formula in Pediatric Acute Promyelocytic Leukemia
Zhang L, Yang XM, Chen J, Hu L, Yang F, Zhou Y, Zhao BB, Zhao W, Zhu XF
Drug Design, Development and Therapy 2021, 15:1633-1640
Published Date: 21 April 2021
In vitro Preparation and Evaluation of Sustained-Release Microcapsules of Salvianolic Acid
Wang YH, Qu T, Wang XL, Yang RP
Drug Design, Development and Therapy 2021, 15:1623-1631
Published Date: 21 April 2021
Pharmacological Management of Gastro-Esophageal Reflux Disease: An Update of the State-of-the-Art
Savarino V, Marabotto E, Zentilin P, Demarzo MG, de Bortoli N, Savarino E
Drug Design, Development and Therapy 2021, 15:1609-1621
Published Date: 19 April 2021
Immunomodulatory Effect of a New Ingredients Group Extracted from Astragalus Through Membrane Separation Technique
Zhang D, Guo Y, Wang Y
Drug Design, Development and Therapy 2021, 15:1595-1607
Published Date: 15 April 2021
Network Pharmacology Analysis of ZiShenWan for Diabetic Nephropathy and Experimental Verification of Its Anti-Inflammatory Mechanism
Guo X, Wu Y, Zhang C, Wu L, Qin L, Liu T
Drug Design, Development and Therapy 2021, 15:1577-1594
Published Date: 15 April 2021
Comparison of Outcomes in Patients with Obesity Between Two Administration Routes of Omeprazole After Laparoscopic Sleeve Gastrectomy: An Open-Label Randomized Clinical Trial
Tan Q, Gao Y, Zhang P, Huo Y, Lu Y, Huang W
Drug Design, Development and Therapy 2021, 15:1569-1576
Published Date: 15 April 2021
Establishment and Verification of UPLC-MS/MS Technique for Pharmacokinetic Drug–Drug Interactions of Selinexor with Posaconazole in Rats
Zhou C, Wang H, Zhou C, Li C, Zhu MJ, Qiu X
Drug Design, Development and Therapy 2021, 15:1561-1568
Published Date: 15 April 2021
An Ensemble Model for Prediction of Vancomycin Trough Concentrations in Pediatric Patients
Huang X, Yu Z, Bu S, Lin Z, Hao X, He W, Yu P, Wang Z, Gao F, Zhang J, Chen J
Drug Design, Development and Therapy 2021, 15:1549-1559
Published Date: 14 April 2021
Preparation Optimization of Bovine Serum Albumin Nanoparticles and Its Application for siRNA Delivery
Wang Y, Chen S, Yang X, Zhang S, Cui C
Drug Design, Development and Therapy 2021, 15:1531-1547
Published Date: 14 April 2021
Effect of Oral versus Vaginal Administration of Estradiol and Dydrogesterone on the Proliferative and Secretory Transformation of Endometrium in Patients with Premature Ovarian Failure and Preparing for Assisted Reproductive Technology
Feng W, Nie L, Wang X, Yang F, Pan P, Deng X
Drug Design, Development and Therapy 2021, 15:1521-1529
Published Date: 14 April 2021
Solasodine, Isolated from Solanum sisymbriifolium Fruits, Has a Potent Anti-Tumor Activity Against Pancreatic Cancer
Fan Y, Li Z, Wu L, Lin F, Shao J, Ma X, Yao Y, Zhuang W, Wang Y
Drug Design, Development and Therapy 2021, 15:1509-1519
Published Date: 13 April 2021
Pharmaceutical Development of 5-Fluorouracil-Eluting Stents for the Potential Treatment of Gastrointestinal Cancers and Related Obstructions
Arafat M, Song Y, Brewer K, Fouladian P, Parikh A, Albrecht H, Blencowe A, Garg S
Drug Design, Development and Therapy 2021, 15:1495-1507
Published Date: 9 April 2021
The Effect of Lidocaine on Postoperative Quality of Recovery and Lung Protection of Patients Undergoing Thoracoscopic Radical Resection of Lung Cancer
Wang L, Sun J, Zhang X, Wang G
Drug Design, Development and Therapy 2021, 15:1485-1493
Published Date: 7 April 2021
Pelvic Ultrasound Parameters of Long-Acting Depot Formulation of Leuprorelin in the Treatment of Idiopathic Central Precocious Puberty in Girls
Yang K, Qi RF, Li RM, Zhang Y, Liu JX
Drug Design, Development and Therapy 2021, 15:1479-1484
Published Date: 7 April 2021
Low-Dose Triple Antihypertensive Combination Therapy in Patients with Hypertension: A Randomized, Double-Blind, Phase II Study [Corrigendum]
Hong SJ, Sung KC, Lim SW, Kim SY, Kim W, Shin J, Park S, Kim HY, Rhee MY
Drug Design, Development and Therapy 2021, 15:1477-1478
Published Date: 7 April 2021
Amino Acid Conjugates of Aminothiazole and Aminopyridine as Potential Anticancer Agents: Synthesis, Molecular Docking and in vitro Evaluation
Naz S, Shah FA, Nadeem H, sarwar S, Tan Z, Imran M, Ali T, Li JB, Li S
Drug Design, Development and Therapy 2021, 15:1459-1476
Published Date: 1 April 2021
White Tip Silver Needle (Slightly Fermented White Tea) Flavonoids Help Prevent Aging via Antioxidative and Anti-Inflammatory Effects
Li C, He J, Yang Y, Gou Y, Wang Z, Chen H, Zhao X
Drug Design, Development and Therapy 2021, 15:1441-1457
Published Date: 31 March 2021
Effect of Spray Drying Conditions on Physical Properties of Panax notoginseng Saponin (PNS) Powder and the Intra-Batch Dissolution Variability of PNS Hydrophilic Matrix Tablet
Yang M, Xu B, Wang X, Li W, Cao J, Li W, Qiao Y
Drug Design, Development and Therapy 2021, 15:1425-1440
Published Date: 30 March 2021
The Risks of miRNA Therapeutics: In a Drug Target Perspective [Erratum]
Zhang S, Cheng Z, Wang Y, Han T
Drug Design, Development and Therapy 2021, 15:1423-1424
Published Date: 30 March 2021
Edaravone Alleviated Propofol-Induced Neurotoxicity in Developing Hippocampus by mBDNF/TrkB/PI3K Pathway
Yang Y, Yi J, Pan M, Hu B, Duan H
Drug Design, Development and Therapy 2021, 15:1409-1422
Published Date: 30 March 2021
Progress of Plant Medicine Derived Extracts and Alkaloids on Modulating Viral Infections and Inflammation
Ti H, Zhuang Z, Yu Q, Wang S
Drug Design, Development and Therapy 2021, 15:1385-1408
Published Date: 31 March 2021
Chlorogenic Acid Inhibits Human Glioma U373 Cell Progression via Regulating the SRC/MAPKs Signal Pathway: Based on Network Pharmacology Analysis
Zhou J, Zhang F, Chen J, Zhang S, Wang H
Drug Design, Development and Therapy 2021, 15:1369-1383
Published Date: 30 March 2021
Caspase Cascade Activation During Apoptotic Cell Death of Human Lung Carcinoma Cells A549 Induced by Marine Sponge Callyspongia aerizusa
Hadisaputri YE, Andika R, Sopyan I, Zuhrotun A, Maharani R, Rachmat R, Abdulah R
Drug Design, Development and Therapy 2021, 15:1357-1368
Published Date: 29 March 2021
Anti-Inflammation, Immunomodulation and Therapeutic Repair in Current Clinical Trials for the Management of COVID-19
Li C, Zhao H, Cheng L, Wang B
Drug Design, Development and Therapy 2021, 15:1345-1356
Published Date: 29 March 2021
Inhibitory Effects of Periplocin on Lymphoma Cells: A Network Pharmacology Approach and Experimental Validation
Zhao R, Han C, Dai S, Wei S, Xiang X, Wang Y, Zhao R, Zhao L, Shan B
Drug Design, Development and Therapy 2021, 15:1333-1344
Published Date: 26 March 2021
Nα-1, 3-Benzenedicarbonyl-Bis-(Amino Acid) and Dipeptide Candidates: Synthesis, Cytotoxic, Antimicrobial and Molecular Docking Investigation
Naglah AM, Moustafa GO, Elhenawy AA, Mounier MM, El-Sayed H, Al-Omar MA, Almehizia AA, Bhat MA
Drug Design, Development and Therapy 2021, 15:1315-1332
Published Date: 25 March 2021
Synthesis of Michael Adducts as Key Building Blocks for Potential Analgesic Drugs: In vitro, in vivo and in silico Explorations
Ahmad S, Mahnashi MH, Alyami BA, Alqahtani YS, Ullah F, Ayaz M, Tariq M, Sadiq A, Rashid U
Drug Design, Development and Therapy 2021, 15:1299-1313
Published Date: 23 March 2021
Application of Topical Immunotherapy in the Treatment of Alopecia Areata: A Review and Update
Mahasaksiri T, Kositkuljorn C, Anuntrangsee T, Suchonwanit P
Drug Design, Development and Therapy 2021, 15:1285-1298
Published Date: 23 March 2021
Role of p38 Mitogen-Activated Protein Kinase in Asthma and COPD: Pathogenic Aspects and Potential Targeted Therapies
Pelaia C, Vatrella A, Gallelli L, Lombardo N, Sciacqua A, Savino R, Pelaia G
Drug Design, Development and Therapy 2021, 15:1275-1284
Published Date: 23 March 2021
The Antimicrobial Peptide Melectin Shows Both Antimicrobial and Antitumor Activity via Membrane Interference and DNA Binding
Liang X, Yan J, Lu Y, Liu S, Chai X
Drug Design, Development and Therapy 2021, 15:1261-1273
Published Date: 19 March 2021
Study on the Mechanism of Jiawei Shengjiang Powder in Improving Male Asthma-Induced Asthenospermia Based on Network Pharmacology and Bioinformatics
Wang JS, Gong XF, Feng JL, Li HS, Li X, Deng S, Ren PZ, Wang JM, Lv MS, Jin RF, Chen QY, Wang B, Cui HS
Drug Design, Development and Therapy 2021, 15:1245-1259
Published Date: 19 March 2021
Drug Discovery and Development in Rare Diseases: Taking a Closer Look at the Tafamidis Story
Burton A, Castaño A, Bruno M, Riley S, Schumacher J, Sultan MB, See Tai S, Judge DP, Patel JK, Kelly JW
Drug Design, Development and Therapy 2021, 15:1225-1243
Published Date: 18 March 2021
Potential Anti-Coronavirus Agents and the Pharmacologic Mechanisms
Yang Y, Cui X, Wei H, Guo C, Zhang Y
Drug Design, Development and Therapy 2021, 15:1213-1223
Published Date: 17 March 2021
Development and Evaluation of a Physiologically Based Pharmacokinetic Drug-Disease Model of Propranolol for Suggesting Model Informed Dosing in Liver Cirrhosis Patients
Kalam MN, Rasool MF, Alqahtani F, Imran I, Rehman AU, Ahmed N
Drug Design, Development and Therapy 2021, 15:1195-1211
Published Date: 17 March 2021
Pharmacokinetics, Bioequivalence and Safety Evaluation of Two Ticagrelor Tablets Under Fasting and Fed Conditions in Healthy Chinese Subjects
Wang J, Zhang H, Wang R, Cai Y
Drug Design, Development and Therapy 2021, 15:1181-1193
Published Date: 15 March 2021
Charge-Transfer Complex of Linifanib with 2,3-dichloro-3,5-dicyano-1,4-benzoquinone: Synthesis, Spectroscopic Characterization, Computational Molecular Modelling and Application in the Development of Novel 96-microwell Spectrophotometric Assay
Darwish IA, Khalil NY, Alsaif NA, Herqash RN, Sayed AYA, Abdel-Rahman HM
Drug Design, Development and Therapy 2021, 15:1167-1180
Published Date: 12 March 2021
Repeated Doses of Ketamine Affect the Infant Rat Urogenital System
Kasıkara H, Sungu N, Arslan M, Kucuk A, Ozturk L, Afandiyeva N, Kavutcu M
Drug Design, Development and Therapy 2021, 15:1157-1165
Published Date: 11 March 2021
Antibacterial and Antimicrobial Effects of Xanthorrhizol in the Prevention of Dental Caries: A Systematic Review
Khalid GS, Hamrah MH, Ghafary ES, Hosseini S, Almasi F
Drug Design, Development and Therapy 2021, 15:1149-1156
Published Date: 11 March 2021
The Efficacy and Safety of Abrocitinib as a Treatment Option for Atopic Dermatitis: A Short Report of the Clinical Data
Napolitano M, Fabbrocini G, Ruggiero A, Marino V, Nocerino M, Patruno C
Drug Design, Development and Therapy 2021, 15:1135-1147
Published Date: 10 March 2021
Withanone from Withania somnifera Attenuates SARS-CoV-2 RBD and Host ACE2 Interactions to Rescue Spike Protein Induced Pathologies in Humanized Zebrafish Model
Balkrishna A, Pokhrel S, Singh H, Joshi M, Mulay VP, Haldar S, Varshney A
Drug Design, Development and Therapy 2021, 15:1111-1133
Published Date: 11 March 2021
Safety, Tolerability and Pharmacokinetics of Single and Multiple Ascending Doses of Benfotiamine in Healthy Subjects
Sheng L, Cao W, Lin P, Chen W, Xu H, Zhong C, Yuan F, Chen H, Li H, Liu C, Yang M, Li X
Drug Design, Development and Therapy 2021, 15:1101-1110
Published Date: 9 March 2021
Pharmacokinetics and Bioequivalence Evaluation of Two Montelukast Sodium Chewable Tablets in Healthy Chinese Volunteers Under Fasted and Fed Conditions
Li W, Wang Y, Pei Y, Xia Y
Drug Design, Development and Therapy 2021, 15:1091-1099
Published Date: 9 March 2021
Investigation of the Active Ingredients and Mechanism of Polygonum cuspidatum in Asthma Based on Network Pharmacology and Experimental Verification
Bi J, Lin YH, Sun Y, Zhang M, Chen Q, Miu X, Tang L, Liu J, Zhu L, Ni Z, Wang X
Drug Design, Development and Therapy 2021, 15:1075-1089
Published Date: 9 March 2021
The Use of Novel Non-Vitamin K Antagonist Oral Anticoagulants Following Closure of the Left Atrial Appendage: Preliminary Results of Clinical Follow-Up
Zhu J, Xu J
Drug Design, Development and Therapy 2021, 15:1067-1073
Published Date: 9 March 2021
Bioactive Compounds from Germinated Brown Rice Protect Cardiomyocytes Against Simulated Ischemic/Reperfusion Injury by Ameliorating Mitochondrial Dysfunction
Demeekul K, Suthammarak W, Petchdee S
Drug Design, Development and Therapy 2021, 15:1055-1066
Published Date: 9 March 2021
An Overview of Bimekizumab for the Treatment of Psoriatic Arthritis: The Evidence so Far
G Oliveira D, Faria R, Torres T
Drug Design, Development and Therapy 2021, 15:1045-1053
Published Date: 9 March 2021
Role of Oxidative Stress and Reduced Endogenous Hydrogen Sulfide in Diabetic Nephropathy
Hussain Lodhi A, Ahmad FUD, Furwa K, Madni A
Drug Design, Development and Therapy 2021, 15:1031-1043
Published Date: 5 March 2021
Superoxide Dismutase as an Intervention for Radiation Therapy-Associated Toxicities: Review and Profile of Avasopasem Manganese as a Treatment Option for Radiation-Induced Mucositis
Sonis ST
Drug Design, Development and Therapy 2021, 15:1021-1029
Published Date: 5 March 2021
Epigallocatechin-3-Gallate Promotes the in vitro Maturation and Embryo Development Following IVF of Porcine Oocytes
Huang K, Li C, Gao F, Fan Y, Zeng F, Meng L, Li L, Zhang S, Wei H
Drug Design, Development and Therapy 2021, 15:1013-1020
Published Date: 4 March 2021
The Effect of Nintedanib on T-Cell Activation, Subsets and Functions
Ubieta K, Thomas MJ, Wollin L
Drug Design, Development and Therapy 2021, 15:997-1011
Published Date: 8 March 2021
Beware of Steroid-Induced Avascular Necrosis of the Femoral Head in the Treatment of COVID-19—Experience and Lessons from the SARS Epidemic
Zhang S, Wang C, Shi L, Xue Q
Drug Design, Development and Therapy 2021, 15:983-995
Published Date: 4 March 2021
Dihydroartemisinin Inhibits TGF-β-Induced Fibrosis in Human Tenon Fibroblasts via Inducing Autophagy
Wang X, Song W, Zhang F, Huang R
Drug Design, Development and Therapy 2021, 15:973-981
Published Date: 3 March 2021
Method Development and Validation for Measuring O6-Methylguanine in Dried Blood Spot Using Ultra High-Performance Liquid Chromatography Tandem Mass Spectrometry
Harahap Y, Vianney AM, Suryadi H
Drug Design, Development and Therapy 2021, 15:963-971
Published Date: 3 March 2021
Geniposide from Gardenia jasminoides var. radicans Makino Attenuates Myocardial Injury in Spontaneously Hypertensive Rats via Regulating Apoptotic and Energy Metabolism Signalling Pathway
Hou Y, Yuan P, Fu Y, Zhang Q, Gao L, Wei Y, Zheng X, Feng W
Drug Design, Development and Therapy 2021, 15:949-962
Published Date: 3 March 2021
Characterization of Oxygenated Heterocyclic Compounds and in vitro Antioxidant Activity of Pomelo Essential Oil
Li G, Cheng Y, Zhang T, Li Y, Han L, Liang G
Drug Design, Development and Therapy 2021, 15:937-947
Published Date: 2 March 2021
Lidocaine Inhibits Myoblast Cell Migration and Myogenic Differentiation Through Activation of the Notch Pathway
Ling X, Ma X, Kuang X, Zou Y, Zhang H, Tang H, Du H, Zhu B, Huang H, Xia Q, Chen M, Mao D, Chen D, Shen H, Yan J
Drug Design, Development and Therapy 2021, 15:927-936
Published Date: 2 March 2021
Zanubrutinib (BGB-3111), a Second-Generation Selective Covalent Inhibitor of Bruton’s Tyrosine Kinase and Its Utility in Treating Chronic Lymphocytic Leukemia
Rhodes JM, Mato AR
Drug Design, Development and Therapy 2021, 15:919-926
Published Date: 2 March 2021
Hydroxyapatite Nanoparticles Facilitate Osteoblast Differentiation and Bone Formation Within Sagittal Suture During Expansion in Rats
Liang W, Ding P, Li G, Lu E, Zhao Z
Drug Design, Development and Therapy 2021, 15:905-917
Published Date: 1 March 2021
Bitter Taste Receptor as a Therapeutic Target in Orthopaedic Disorders
Cheng W, Yao M, Liu F
Drug Design, Development and Therapy 2021, 15:895-903
Published Date: 26 February 2021
Low Frequency of Integrase Inhibitor Resistance Mutations Among Therapy-Naïve HIV Patients in Southeast China
Lai J, Liu Y, Han X, Huang A, Lin J, Ao W, Ye H, Chen Y
Drug Design, Development and Therapy 2021, 15:889-894
Published Date: 26 February 2021
Taxifolin, Extracted from Waste Larix olgensis Roots, Attenuates CCl4-Induced Liver Fibrosis by Regulating the PI3K/AKT/mTOR and TGF-β1/Smads Signaling Pathways
Liu X, Liu W, Ding C, Zhao Y, Chen X, Ling D, Zheng Y, Cheng Z
Drug Design, Development and Therapy 2021, 15:871-887
Published Date: 26 February 2021
Aloperine Inhibits Proliferation and Promotes Apoptosis in Colorectal Cancer Cells by Regulating the circNSUN2/miR-296-5p/STAT3 Pathway
Han W, Kong D, Lu Q, Zhang W, Fan Z
Drug Design, Development and Therapy 2021, 15:857-870
Published Date: 25 February 2021
Breviscapine Pretreatment Inhibits Myocardial Inflammation and Apoptosis in Rats After Coronary Microembolization by Activating the PI3K/Akt/GSK-3β Signaling Pathway
Chen ZQ, Zhou Y, Chen F, Huang JW, Zheng J, Li HL, Li T, Li L
Drug Design, Development and Therapy 2021, 15:843-855
Published Date: 25 February 2021
Current Understanding on Perioperative Management in Lung Cancer: Implications for Anesthetic Considerations
Wang J, Liu L, Song Y, Jiao J, Zhong Y
Drug Design, Development and Therapy 2021, 15:835-842
Published Date: 25 February 2021
Effects of Sugammadex versus Neostigmine on Intraoperative Coagulation Profiles in Patients with Thyroidectomy
Zhao D, Fang J, Xiong W, Lin J, Chen W, Wu C
Drug Design, Development and Therapy 2021, 15:829-834
Published Date: 25 February 2021
Predicting and Exploring the Mechanisms of Erzhi Pill in Prevention and Treatment of Osteoporosis Based on Network Pharmacology and Zebrafish Experiments
Zhong Z, Li Y, Chen Y, Chen W, Li S, Lv X, Luo S
Drug Design, Development and Therapy 2021, 15:817-827
Published Date: 24 February 2021
Efficacy and Safety of Retinol Palmitate Ophthalmic Solution in the Treatment of Dry Eye: A Japanese Phase II Clinical Trial [Corrigendum]
Toshida H, Funaki T, Ono K, Tabuchi N, Watanabe S, Seki T, Otake H, Kato T, Ebihara N, Murakami A
Drug Design, Development and Therapy 2021, 15:813-816
Published Date: 24 February 2021
Convallatoxin Promotes M2 Macrophage Polarization to Attenuate Atherosclerosis Through PPARγ-Integrin αvβ5 Signaling Pathway
Zhang Y, Shi X, Han J, Peng W, Fang Z, Zhou Y, Xu X, Lin J, Xiao F, Zhao L, Lin Y
Drug Design, Development and Therapy 2021, 15:803-812
Published Date: 23 February 2021
Dopamine-Mediated Vanillin Multicomponent Derivative Synthesis via Grindstone Method: Application of Antioxidant, Anti-Tyrosinase, and Cytotoxic Activities
Mani A, Ahamed A, Ali D, Alarifi S, Akbar I
Drug Design, Development and Therapy 2021, 15:787-802
Published Date: 23 February 2021
The Volatile Oil of Zanthoxylum bungeanum Pericarp Improved the Hypothalamic-Pituitary-Adrenal Axis and Gut Microbiota to Attenuate Chronic Unpredictable Stress-Induced Anxiety Behavior in Rats
Wei D, Zhao Y, Zhang M, Zhu L, Wang L, Yuan X, Wu C
Drug Design, Development and Therapy 2021, 15:769-786
Published Date: 22 February 2021
Mechanism of Action of Xiaoyao San in Treatment of Ischemic Stroke is Related to Anti-Apoptosis and Activation of PI3K/Akt Pathway
Xu Y, Chen W, Chen Z, Huang M, Yang F, Zhang Y
Drug Design, Development and Therapy 2021, 15:753-767
Published Date: 22 February 2021
The Effectiveness of Ruxolitinib for Acute/Chronic Graft-versus-Host Disease in Children: A Retrospective Study
Yang W, Zhu G, Qin M, Li Z, Wang B, Yang J, Wang T
Drug Design, Development and Therapy 2021, 15:743-752
Published Date: 22 February 2021
Addition of Celebrex and Pregabalin to Ropivacaine for Posterior Spinal Surgery: A Randomized, Double-Blinded, Placebo-Controlled Trial
Zhang Y, He B, Zhao J, Zhang M, Ren Q, Zhang W, Xu S, Quan Z, Ou Y
Drug Design, Development and Therapy 2021, 15:735-742
Published Date: 22 February 2021
The Risks of miRNA Therapeutics: In a Drug Target Perspective
Zhang S, Cheng Z, Wang Y, Han T
Drug Design, Development and Therapy 2021, 15:721-733
Published Date: 22 February 2021
Danggui Buxue Decoction in the Treatment of Metastatic Colon Cancer: Network Pharmacology Analysis and Experimental Validation
Feng SH, Zhao B, Zhan X, Motanyane R, Wang SM, Li A
Drug Design, Development and Therapy 2021, 15:705-720
Published Date: 24 February 2021
Glucocorticoid-Like Activity of Escin: A New Mechanism for an Old Drug
Gallelli L, Cione E, Wang T, Zhang L
Drug Design, Development and Therapy 2021, 15:699-704
Published Date: 24 February 2021
The Effectiveness and Safety of Intravenous Dexmedetomidine of Different Concentrations Combined with Butorphanol for Post-Caesarean Section Analgesia: A Randomized Controlled Trial
Liu S, Peng P, Hu Y, Liu C, Cao X, Yang C, Gao M
Drug Design, Development and Therapy 2021, 15:689-698
Published Date: 18 February 2021
Trans-Cinnamaldehyde Increases Random Pattern Flap Survival Through Activation of the Nitric Oxide Pathway
Luo X, Zhao B, Chen B, Chen H, Han T, Bsoul NBN, Yan H
Drug Design, Development and Therapy 2021, 15:679-688
Published Date: 18 February 2021
Thiazole-Based Thiosemicarbazones: Synthesis, Cytotoxicity Evaluation and Molecular Docking Study
Gomha SM, Abdelhady HA, Hassain DZH, Abdelmonsef AH, El-Naggar M, Elaasser MM, Mahmoud HK
Drug Design, Development and Therapy 2021, 15:659-677
Published Date: 17 February 2021
Pharmacokinetic and Pharmacodynamic Comparison of Two Formulations of a Fixed-Dose Combination of Gemigliptin/Rosuvastatin 50/20 mg: A Randomized, Open-Label, Single-Dose, Two-Way Crossover Study
Yang E, Yoo H, Jang IJ, Yu KS, Lee S
Drug Design, Development and Therapy 2021, 15:651-658
Published Date: 17 February 2021
Progress in Clinical Research on Gonadotropin-Releasing Hormone Receptor Antagonists for the Treatment of Prostate Cancer
Liu YF, Fu SQ, Yan YC, Gong BB, Xie WJ, Yang XR, Sun T, Ma M
Drug Design, Development and Therapy 2021, 15:639-649
Published Date: 16 February 2021
Safety, Tolerability, and Pharmacokinetics of Ibuprofenamine Hydrochloride Spray (NSAIDs), a New Drug for Rheumatoid Arthritis and Osteoarthritis, in Healthy Chinese Subjects
Xie P, Xue W, Qi W, Li Y, Yang L, Yang Z, Shi A
Drug Design, Development and Therapy 2021, 15:629-638
Published Date: 16 February 2021
Treatment of Severe Acute Bacterial Keratitis in Rabbits Using Continuous Topical Ocular Instillation with Norvancomycin
Lin W, Zhao L, Tan Q, Lin D
Drug Design, Development and Therapy 2021, 15:617-628
Published Date: 16 February 2021
Effect of Different Dosage Frequency of Polymyxin B on Rat Nephrotoxicity
Sun W, Hu B, Zhang X, Wang Y, Xiang Z, Lin G
Drug Design, Development and Therapy 2021, 15:611-616
Published Date: 16 February 2021
Preparation, Characterization and in vitro/in vivo Evaluation of Lovastatin-Loaded PLGA Microspheres by Local Administration for Femoral Head Necrosis
Sun Y, Long D
Drug Design, Development and Therapy 2021, 15:601-610
Published Date: 16 February 2021
Nephroprotective Effect of Adropinin Against Streptozotocin-Induced Diabetic Nephropathy in Rats: Inflammatory Mechanism and YAP/TAZ Factor
Guo L, Jiang B, Li D, Xiao X
Drug Design, Development and Therapy 2021, 15:589-600
Published Date: 16 February 2021
Effects of Quercetin on the Efficacy of Various Chemotherapeutic Drugs in Cervical Cancer Cells
Xu W, Xie S, Chen X, Pan S, Qian H, Zhu X
Drug Design, Development and Therapy 2021, 15:577-588
Published Date: 15 February 2021
Self-Nanoemulsifying Drug Delivery System of Genkwanin: A Novel Approach for Anti-Colitis-Associated Colorectal Cancer
Yin HF, Yin CM, Ouyang T, Sun SD, Chen WG, Yang XL, He X, Zhang CF
Drug Design, Development and Therapy 2021, 15:557-576
Published Date: 12 February 2021
Magnesium Isoglycyrrhizinate Alleviates Arsenic Trioxide-Induced Cardiotoxicity: Contribution of Nrf2 and TLR4/NF-κB Signaling Pathway
Zheng B, Yang Y, Li J, Li J, Zuo S, Chu X, Xu S, Ma D, Chu L
Drug Design, Development and Therapy 2021, 15:543-556
Published Date: 12 February 2021
Synergistic Anticancer Strategy of Sonodynamic Therapy Combined with PI-103 Against Hepatocellular Carcinoma
Yang H, Jing H, Han X, Tan H, Cheng W
Drug Design, Development and Therapy 2021, 15:531-542
Published Date: 11 February 2021
L-Cysteine Provides Neuroprotection of Hypoxia-Ischemia Injury in Neonatal Mice via a PI3K/Akt-Dependent Mechanism
Li T, Li J, Li T, Zhao Y, Ke H, Wang S, Liu D, Wang Z
Drug Design, Development and Therapy 2021, 15:517-529
Published Date: 11 February 2021
Budesonide/Formoterol Anti-Inflammatory Reliever and Maintenance or Fluticasone Propionate/Salmeterol Plus as-Needed, Short-Acting β2 Agonist: Real-World Effectiveness in patients Without Optimally Controlled asthma (REACT) Study [Corrigendum]
Cheng SL, Ho ML, Lai YF, Wang HC, Hsu JY, Liu SF, Huang MS, Lee CH, Lin CH, Hang LW, Liu YC, Yang KY, Wang JH
Drug Design, Development and Therapy 2021, 15:515-516
Published Date: 12 February 2021
Loganin Attenuates Septic Acute Renal Injury with the Participation of AKT and Nrf2/HO-1 Signaling Pathways
Zhang J, Wang C, Kang K, Liu H, Liu X, Jia X, Yu K
Drug Design, Development and Therapy 2021, 15:501-513
Published Date: 11 February 2021
EGCG Regulates Cell Apoptosis of Human Umbilical Vein Endothelial Cells Grown on 316L Stainless Steel for Stent Implantation
Wang J, Wang Y, Zhao Y, Zhao J, Zhang B, Xu K
Drug Design, Development and Therapy 2021, 15:493-499
Published Date: 11 February 2021
Long Noncoding RNA SOX2-OT Aggravates Doxorubicin-Induced Apoptosis of Cardiomyocyte by Targeting miR-942-5p/DP5
Wang H, Lin X, Li J, Zeng G, Xu T
Drug Design, Development and Therapy 2021, 15:481-492
Published Date: 11 February 2021
Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry for Simultaneous Determination of Antipsychotic Drugs in Human Plasma and Its Application in Therapeutic Drug Monitoring
Qi Y, Liu G
Drug Design, Development and Therapy 2021, 15:463-479
Published Date: 12 February 2021
Profile of Enfortumab Vedotin in the Treatment of Urothelial Carcinoma: The Evidence to Date
Moussa M, Papatsoris A, Abou Chakra M, Dellis A
Drug Design, Development and Therapy 2021, 15:453-462
Published Date: 11 February 2021
Effect of Evodiamine on Rat Colonic Hypermotility Induced by Water Avoidance Stress and the Underlying Mechanism
Ren H, Yuan F, Tan W, Ding Y, An P, Luo H
Drug Design, Development and Therapy 2021, 15:441-452
Published Date: 10 February 2021
Individualized Vancomycin Dosing with Therapeutic Drug Monitoring and Pharmacokinetic Consultation Service: A Large-Scale Retrospective Observational Study
Kim SM, Lee HS, Hwang NY, Kim K, Park HD, Lee SY
Drug Design, Development and Therapy 2021, 15:423-440
Published Date: 4 March 2021
Zafirlukast in Combination with Pseudohypericin Attenuates Spinal Cord Injury and Motor Function in Experimental Mice [Corrigendum]
Chen XG, Hua F, Wang SG, Xu YY, Yue HT, Sun J
Drug Design, Development and Therapy 2021, 15:419-422
Published Date: 9 February 2021
Development and Characterization of PLGA Nanoparticle-Laden Hydrogels for Sustained Ocular Delivery of Norfloxacin in the Treatment of Pseudomonas Keratitis: An Experimental Study
Gebreel RM, Edris NA, Elmofty HM, Tadros MI, El-Nabarawi MA, Hassan DH
Drug Design, Development and Therapy 2021, 15:399-418
Published Date: 5 February 2021
Design, Synthesis, Molecular Modelling, and Biological Evaluation of Oleanolic Acid-Arylidene Derivatives as Potential Anti-Inflammatory Agents
Hassan Mir R, Godavari G, Siddiqui NA, Ahmad B, Mothana RA, Ullah R, Almarfadi OM, Jachak SM, Masoodi MH
Drug Design, Development and Therapy 2021, 15:385-397
Published Date: 4 February 2021
Thiazolidine Derivatives Attenuate Carrageenan-Induced Inflammatory Pain in Mice
Malik Z, Abbas M, Al Kury LT, Shah FA, Alam M, Khan AU, Nadeem H, Alghamdi S, Sahibzada MUK, Li S
Drug Design, Development and Therapy 2021, 15:369-384
Published Date: 4 February 2021
Irisin Protects Against Hind Limb Ischemia Reperfusion Injury
Küçük A, Polat Y, Kılıçarslan A, Süngü N, Kartal H, Dursun AD, Arslan M
Drug Design, Development and Therapy 2021, 15:361-368
Published Date: 4 February 2021
New Approach in Ocular Drug Delivery: In vitro and ex vivo Investigation of Cyclodextrin-Containing, Mucoadhesive Eye Drop Formulations
Bíró T, Bocsik A, Jurišić Dukovski B, Gróf I, Lovrić J, Csóka I, Deli MA, Aigner Z
Drug Design, Development and Therapy 2021, 15:351-360
Published Date: 3 February 2021
Therapeutic Effects of Modified Gengnianchun Formula on Stress-Induced Diminished Ovarian Reserve Based on Experimental Approaches and Network Pharmacology [Erratum]
Gao L, Zhang Y, Xu H, Zhao F, Wang W
Drug Design, Development and Therapy 2021, 15:349-350
Published Date: 27 January 2021
A Retrospective Observational Study of Anlotinib in Patients with Platinum-Resistant or Platinum-Refractory Epithelial Ovarian Cancer
Cui Q, Hu Y, Ma D, Liu H
Drug Design, Development and Therapy 2021, 15:339-347
Published Date: 27 January 2021
Tezepelumab as an Emerging Therapeutic Option for the Treatment of Severe Asthma: Evidence to Date
Dorey-Stein ZL, Shenoy KV
Drug Design, Development and Therapy 2021, 15:331-338
Published Date: 27 January 2021
CircNRIP1 Modulates the miR-515-5p/IL-25 Axis to Control 5-Fu and Cisplatin Resistance in Nasopharyngeal Carcinoma
Lin J, Qin H, Han Y, Li X, Zhao Y, Zhai G
Drug Design, Development and Therapy 2021, 15:323-330
Published Date: 27 January 2021
Administration of Dexmedetomidine Does Not Produce Long-Term Protective Effect on Testicular Damage Post Testicular Ischemia-Reperfusion Injury
Xiao J, Wan W, Zhang Y, Ma J, Yan L, Luo Y, Tang J
Drug Design, Development and Therapy 2021, 15:315-321
Published Date: 27 January 2021
Phenotyping Study of Cyclophosphamide 4-Hydroxylation in Malay Cancer Patients
Fityatal Hasanah YI, Harahap Y, Purwanto DJ
Drug Design, Development and Therapy 2021, 15:305-313
Published Date: 26 January 2021
Gypenosides Inhibit Inflammatory Response and Apoptosis of Endothelial and Epithelial Cells in LPS-Induced ALI: A Study Based on Bioinformatic Analysis and in vivo/vitro Experiments
Tu Q, Zhu Y, Yuan Y, Guo L, Liu L, Yao L, Zou Y, Li J, Chen F
Drug Design, Development and Therapy 2021, 15:289-303
Published Date: 25 January 2021
Physcion Protects Rats Against Cerebral Ischemia-Reperfusion Injury via Inhibition of TLR4/NF-kB Signaling Pathway
Dong X, Wang L, Song G, Cai X, Wang W, Chen J, Wang G
Drug Design, Development and Therapy 2021, 15:277-287
Published Date: 25 January 2021
Effects of Caffeic Acid and Its Derivatives on Bone: A Systematic Review
Ekeuku SO, Pang KL, Chin KY
Drug Design, Development and Therapy 2021, 15:259-275
Published Date: 22 January 2021
Paeoniflorin Sensitizes Breast Cancer Cells to Tamoxifen by Downregulating microRNA-15b via the FOXO1/CCND1/β-Catenin Axis
Wang Y, Wang Q, Li X, Luo G, Shen M, Shi J, Wang X, Tang L
Drug Design, Development and Therapy 2021, 15:245-257
Published Date: 22 January 2021
Gracillin Isolated from Reineckia carnea Induces Apoptosis of A549 Cells via the Mitochondrial Pathway
Yang J, Cao L, Li Y, Liu H, Zhang M, Ma H, Wang B, Yuan X, Liu Q
Drug Design, Development and Therapy 2021, 15:233-243
Published Date: 20 January 2021
Galangin Improved Non-Alcoholic Fatty Liver Disease in Mice by Promoting Autophagy [Corrigendum]
Zhang X, Deng Y, Xiang J, Liu H, Zhang J, Liao J, Chen K, Liu B, Liu J, Pu Y
Drug Design, Development and Therapy 2021, 15:231-232
Published Date: 20 January 2021
Clinical Significance of Continuable Treatment with Nintedanib Over 12 Months for Idiopathic Pulmonary Fibrosis in a Real-World Setting
Kato M, Sasaki S, Tateyama M, Arai Y, Motomura H, Sumiyoshi I, Ochi Y, Watanabe J, Ihara H, Togo S, Takahashi K
Drug Design, Development and Therapy 2021, 15:223-230
Published Date: 18 January 2021
H2O2-Inactivated Salmonella typhimurium RE88 Strain as a New Cancer Vaccine Carrier: Evaluation in a Mouse Model of Cancer
Fan Y, Bai T, Tian Y, Zhou B, Wang Y, Yang L
Drug Design, Development and Therapy 2021, 15:209-222
Published Date: 15 January 2021
Quaternary Lidocaine Derivatives: Past, Present, and Future
Wang Q, Zhang Y, Liu J, Zhang W
Drug Design, Development and Therapy 2021, 15:195-207
Published Date: 14 January 2021
Bioequivalence and Pharmacokinetic Profiles of Generic and Branded Obeticholic Acid in Healthy Chinese Subjects Under Fasting and Fed Conditions
Wang MN, Yu HT, Li YQ, Zeng Y, Yang S, Yang GP, Pei Q, Huang J
Drug Design, Development and Therapy 2021, 15:185-193
Published Date: 14 January 2021
Combination of Sodium Cantharidinate with Cisplatin Synergistically Hampers Growth of Cervical Cancer
Chen X, Zhou M, Fan W, Yang M, Yang L
Drug Design, Development and Therapy 2021, 15:171-183
Published Date: 13 January 2021
Subcutaneous Delivery of High-Dose/Volume Biologics: Current Status and Prospect for Future Advancements
Badkar AV, Gandhi RB, Davis SP, LaBarre MJ
Drug Design, Development and Therapy 2021, 15:159-170
Published Date: 13 January 2021
Spotlight on Pimavanserin Tartrate and Its Therapeutic Potential in the Treatment of Major Depressive Disorder: The Evidence to Date
Soogrim V, Ruberto VL, Murrough J, Jha MK
Drug Design, Development and Therapy 2021, 15:151-157
Published Date: 13 January 2021
Preparation and Characterization of Tacrolimus-Loaded SLNs in situ Gel for Ocular Drug Delivery for the Treatment of Immune Conjunctivitis
Sun K, Hu K
Drug Design, Development and Therapy 2021, 15:141-150
Published Date: 12 January 2021
Capsaicin Inhibits Proliferation and Induces Apoptosis in Breast Cancer by Down-Regulating FBI-1-Mediated NF-κB Pathway
Chen M, Xiao C, Jiang W, Yang W, Qin Q, Tan Q, Lian B, Liang Z, Wei C
Drug Design, Development and Therapy 2021, 15:125-140
Published Date: 12 January 2021
Chronic Obstructive Pulmonary Disease Treatment and Pharmacist-Led Medication Management
Li LC, Han YY, Zhang ZH, Zhou WC, Fang HM, Qu J, Kan LD
Drug Design, Development and Therapy 2021, 15:111-124
Published Date: 12 January 2021
Network Pharmacology and Experimental Evidence Identify the Mechanism of Astragaloside IV in Oxaliplatin Neurotoxicity
Xu J, Guan Z, Wang X, Sun D, Li Y, Pei B, Lu Y, Yuan L, Zhang X
Drug Design, Development and Therapy 2021, 15:99-110
Published Date: 12 January 2021
Roflumilast Attenuates Doxorubicin-Induced Cardiotoxicity by Targeting Inflammation and Cellular Senescence in Cardiomyocytes Mediated by SIRT1
Zhang S, Wu P, Liu J, Du Y, Yang Z
Drug Design, Development and Therapy 2021, 15:87-97
Published Date: 11 January 2021
A Review of Drug Therapy in Vestibular Schwannoma
Long J, Zhang Y, Huang X, Ren J, Zhong P, Wang B
Drug Design, Development and Therapy 2021, 15:75-85
Published Date: 8 January 2021
Pristimerin Protects Against OVX-Mediated Bone Loss by Attenuating Osteoclast Formation and Activity via Inhibition of RANKL-Mediated Activation of NF-κB and ERK Signaling Pathways
Li X, Lin X, Wu Z, Su Y, Liang J, Chen R, Yang X, Hou L, Zhao J, Liu Q, Xu F
Drug Design, Development and Therapy 2021, 15:61-74
Published Date: 7 January 2021
Inhibition of Pre-B Cell Colony Enhancing Factor Reduces Lung Injury in Rats Receiving Cardiopulmonary Bypass
Lu C, Yang W, Zhou J, Zhang Z, Gong Y, Hu F, Yu W, Dong X
Drug Design, Development and Therapy 2021, 15:51-60
Published Date: 7 January 2021
Lactobacillus plantarum KSFY06 Prevents Inflammatory Response and Oxidative Stress in Acute Liver Injury Induced by D-Gal/LPS in Mice
Li C, Si J, Tan F, Park KY, Zhao X
Drug Design, Development and Therapy 2021, 15:37-50
Published Date: 6 January 2021
RASSF1A Enhances Chemosensitivity of NSCLC Cells Through Activating Autophagy by Regulating MAP1S to Inactivate Keap1-Nrf2 Pathway
Wang J, Zhang X, Yang F, Yang Y, Wang T, Liu W, Zhou H, Zhao W
Drug Design, Development and Therapy 2021, 15:21-35
Published Date: 6 January 2021
Current Status and Perspectives of Protease Inhibitors and Their Combination with Nanosized Drug Delivery Systems for Targeted Cancer Therapy
Rudzińska M, Daglioglu C, Savvateeva LV, Kaci FN, Antoine R, Zamyatnin Jr AA
Drug Design, Development and Therapy 2021, 15:9-20
Published Date: 6 January 2021
Targeting Protein Neddylation to Inactivate Cullin-RING Ligases by Gossypol: A Lucky Hit or a New Start?
Yu Q, Sun Y
Drug Design, Development and Therapy 2021, 15:1-8
Published Date: 6 January 2021