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Drug Design, Development and Therapy


Archive: Volume 10, 2016

Folic acid-conjugated amphiphilic alternating copolymer as a new active tumor targeting drug delivery platform

Li X, Szewczuk MR, Malardier-Jugroot C

Drug Design, Development and Therapy 2016, 10:4101-4110

Published Date: 15 December 2016

Structure-based virtual screening and characterization of a novel IL-6 antagonistic compound from synthetic compound database

Wang J, Qiao C, Xiao H, Lin Z, Li Y, Zhang J, Shen B, Fu T, Feng J

Drug Design, Development and Therapy 2016, 10:4091-4100

Published Date: 15 December 2016

Protective effects of vitamin C and vitamin E against hysterosalpingography-induced epithelial degeneration and proliferation in rat endometrium

Pala Ş, Atilgan R, Kuloğlu T, Kara M, Başpınar M, Can B, Artaş G

Drug Design, Development and Therapy 2016, 10:4079-4089

Published Date: 15 December 2016

Design and in vitro/in vivo evaluation of sustained-release floating tablets of itopride hydrochloride

Ahmed SM, Ahmed Ali A, Ali AMA, Hassan OA

Drug Design, Development and Therapy 2016, 10:4061-4071

Published Date: 14 December 2016

Comparison of oral absorption models for pregabalin: usefulness of transit compartment model

Hong T, Han S, Lee J, Jeon S, Yim DS

Drug Design, Development and Therapy 2016, 10:3995-4003

Published Date: 7 December 2016

Impact of prostaglandin glaucoma drops on platelet-activating factor action: an in vitro study

Moschos MM, Nitoda E, Chatziralli IP, Panos GD, Demopoulos CA

Drug Design, Development and Therapy 2016, 10:3977-3981

Published Date: 7 December 2016

Paracetamol sharpens reflection and spatial memory: a double-blind randomized controlled study in healthy volunteers

Pickering G, Macian N, Dubray C, Pereira B

Drug Design, Development and Therapy 2016, 10:3969-3976

Published Date: 5 December 2016

Dose-dependent effects of cisplatin on the severity of testicular injury in Sprague Dawley rats: reactive oxygen species and endoplasmic reticulum stress

Soni KK, Kim HK, Choi BR, Karna KK, You JH, Cha JS, Shin YS, Lee SW, Kim CY, Park JK

Drug Design, Development and Therapy 2016, 10:3959-3968

Published Date: 12 December 2016

Increased therapeutic efficacy of a newly synthesized tyrosinase inhibitor by solid lipid nanoparticles in the topical treatment of hyperpigmentation

Al-Amin M, Cao J, Naeem M, Banna H, Kim M, Jung Y, Chung HY, Moon HR, Yoo J

Drug Design, Development and Therapy 2016, 10:3947-3957

Published Date: 2 December 2016

Loading cisplatin onto 6-mercaptopurine covalently modified MSNS: a nanomedicine strategy to improve the outcome of cisplatin therapy

Lv X, Zhao M, Wang Y, Hu X, Wu J, Jiang X, Li S, Cui C, Peng S

Drug Design, Development and Therapy 2016, 10:3933-3946

Published Date: 1 December 2016

Effect of peritoneal dialysis fluid containing osmo-metabolic agents on human endothelial cells

Bonomini M, Di Silvestre S, Di Tomo P, Di Pietro N, Mandatori D, Di Liberato L, Sirolli V, Chiarelli F, Indiveri C, Pandolfi A, Arduini A

Drug Design, Development and Therapy 2016, 10:3925-3932

Published Date: 28 November 2016

Statistical modeling methods to analyze the impacts of multiunit process variability on critical quality attributes of Chinese herbal medicine tablets

Sun F, Xu B, Zhang Y, Dai SY, Yang C, Cui XL, Shi XY, Qiao YJ

Drug Design, Development and Therapy 2016, 10:3909-3924

Published Date: 28 November 2016

Non-imidazole-based histamine H3 receptor antagonists with anticonvulsant activity in different seizure models in male adult rats

Sadek B, Saad A, Latacz G, Kuder K, Olejarz A, Karcz T, Stark H, Kieć-Kononowicz K

Drug Design, Development and Therapy 2016, 10:3879-3898

Published Date: 25 November 2016

Design, synthesis and evaluation of VEGF-siRNA/CRS as a novel vector for gene delivery

Zhao W, Zhang YF, Jiang XY, Cui CY

Drug Design, Development and Therapy 2016, 10:3851-3865

Published Date: 24 November 2016

Smart nanocrystals of artemether: fabrication, characterization, and comparative in vitro and in vivo antimalarial evaluation

Shah SMH, Ullah F, Khan S, Shah SMM, Matas MD, Hussain Z, Minhas MU, AbdEl-Salam NM, Assi KH, Isreb M

Drug Design, Development and Therapy 2016, 10:3837-3850

Published Date: 24 November 2016

Feasibility of sequential adjuvant chemotherapy with a 3-month oxaliplatin-based regimen followed by 3 months of capecitabine in patients with stage III and high-risk stage II colorectal cancer: JSWOG-C2 study

Tsuruta A, Yamashita K, Tanioka H, Tsuji A, Inukai M, Yamakawa T, Yamatsuji T, Yoshimitsu M, Toyota K, Yamano T, Nagasaka T, Okajima M

Drug Design, Development and Therapy 2016, 10:3827-3835

Published Date: 23 November 2016

Fabrication of anti-vitiligo ointment containing Psoralea corylifolia: in vitro and in vivo characterization

Hussain I, Hussain N, Manan A, Rashid A, Khan B, Bukhsh S

Drug Design, Development and Therapy 2016, 10:3805-3816

Published Date: 22 November 2016

CARD9 as a potential target in cardiovascular disease

Peterson MR, Haller SE, Ren J, Nair S, He G

Drug Design, Development and Therapy 2016, 10:3799-3804

Published Date: 22 November 2016

Comparison of bile salt/phosphatidylcholine mixed micelles in solubilization to sterols and stability

Guo Q, Cai J, Li PY, Xu DL, Ni XM, Wen H, Liu D, Lin SZ, Hu HY

Drug Design, Development and Therapy 2016, 10:3789-3798

Published Date: 17 November 2016

Increased localized delivery of piroxicam by cationic nanoparticles after intra-articular injection

Kim SR, Ho MJ, Kim SH, Cho HR, Kim HS, Choi YS, Choi YW, Kang MJ

Drug Design, Development and Therapy 2016, 10:3779-3787

Published Date: 16 November 2016

Dietary arginine silicate inositol complex inhibits periodontal tissue loss in rats with ligature-induced periodontitis

Dundar S, Eltas A, Hakki SS, Malkoc S, Uslu MO, Tuzcu M, Komorowski J, Ozercan IH, Akdemir F, Sahin K

Drug Design, Development and Therapy 2016, 10:3771-3778

Published Date: 15 November 2016

Pharmacokinetics, pharmacodynamics and safety of CKD-519, a CETP inhibitor, in healthy subjects

Kim CO, Oh ES, Choi CG, Kim YJ, Lee S, Kim S, Park MS

Drug Design, Development and Therapy 2016, 10:3763-3770

Published Date: 15 November 2016

Oncolytic adenovirus expressing interleukin-18 improves antitumor activity of dacarbazine for malignant melanoma

Yang C, Cao H, Liu N, Xu K, Ding M, Mao LJ

Drug Design, Development and Therapy 2016, 10:3755-3761

Published Date: 15 November 2016

Lentivirus-mediated knockdown of NLK inhibits small-cell lung cancer growth and metastasis

Lv MT, Li YM, Tian X, Dai SD, Sun J, Jin GJ, Jiang SY

Drug Design, Development and Therapy 2016, 10:3737-3746

Published Date: 15 November 2016

Systematic review and meta-analysis of randomized controlled trials on Wenxin keli

Wang XY, Wang Y, Feng XY, Lu Y, Zhang Y, Wang WW, Zhu WT

Drug Design, Development and Therapy 2016, 10:3725-3736

Published Date: 14 November 2016

Low-dose modified-release prednisone in axial spondyloarthritis: 3-month efficacy and tolerability

Bandinelli F, Scazzariello F, Pimenta da Fonseca E, Barreto Santiago M, Marcassa C, Nacci F, Matucci Cerinic M

Drug Design, Development and Therapy 2016, 10:3717-3724

Published Date: 14 November 2016

Effects of resveratrol on P-glycoprotein and cytochrome P450 3A in vitro and on pharmacokinetics of oral saquinavir in rats

Li JP, Liu Y, Zhang JR, Yu XT, Wang XL, Zhao LB

Drug Design, Development and Therapy 2016, 10:3699-3706

Published Date: 15 November 2016

Study of the antibacterial and antifungal activities of synthetic benzyl bromides, ketones, and corresponding chalcone derivatives

Shakhatreh MA, Al-Smadi ML, Khabour OF, Shuaibu FA, Hussein EI, Alzoubi KH

Drug Design, Development and Therapy 2016, 10:3653-3660

Published Date: 8 November 2016

Anticonvulsant effects of isomeric nonimidazole histamine H3 receptor antagonists

Sadek B, Saad A, Schwed JS, Weizel L, Walter M, Stark H

Drug Design, Development and Therapy 2016, 10:3633-3651

Published Date: 7 November 2016

Mechanism and pharmacological rescue of berberine-induced hERG channel deficiency [Corrigendum]

Yan M, Zhang KP, Shi YH, Feng LF, Lv L, Li BX

Drug Design, Development and Therapy 2016, 10:3573-3574

Published Date: 1 November 2016

Evaluating the cytotoxic effects of the water extracts of four anticancer herbs against human malignant melanoma cells

Ling BB, Michel D, Sakharkar MK, Yang J

Drug Design, Development and Therapy 2016, 10:3563-3572

Published Date: 1 November 2016

Effects of renal function on pharmacokinetics and pharmacodynamics of lesinurad in adult volunteers

Gillen M, Valdez S, Zhou D, Kerr B, Lee CA, Shen Z

Drug Design, Development and Therapy 2016, 10:3555-3562

Published Date: 1 November 2016

Mimetics of brain-derived neurotrophic factor loops 1 and 4 are active in a model of ischemic stroke in rats

Gudasheva TA, Povarnina P, Logvinov IO, Antipova TA, Seredenin SB

Drug Design, Development and Therapy 2016, 10:3545-3553

Published Date: 2 November 2016

Synthesis, anti-inflammatory, analgesic, COX1/2-inhibitory activity, and molecular docking studies of hybrid pyrazole analogues

Alam MJ, Alam O, Khan SA, Naim MJ, Islamuddin M, Deora GS

Drug Design, Development and Therapy 2016, 10:3529-3543

Published Date: 31 October 2016

Supratherapeutic dose evaluation and effect of lesinurad on cardiac repolarization: a thorough QT/QTc study

Shen Z, Gillen M, Tieu K, Nguyen M, Harmon E, Wilson DM, Kerr B, Lee CA

Drug Design, Development and Therapy 2016, 10:3509-3517

Published Date: 27 October 2016

Cardioprotective activity of placental growth factor combined with oral supplementation of L-arginine in a rat model of acute myocardial infarction

Luo L, Chen B, Huang Y, Liang Z, Li S, Yin Y, Chen J, Wu W

Drug Design, Development and Therapy 2016, 10:3483-3492

Published Date: 28 October 2016

Clinical utility of lanreotide Autogel® in gastroenteropancreatic neuroendocrine tumors

Paragliola RM, Prete A, Papi G, Torino F, Corsello A, Pontecorvi A, Corsello SM

Drug Design, Development and Therapy 2016, 10:3459-3470

Published Date: 25 October 2016

α-Aminoadipic acid protects against retinal disruption through attenuating Müller cell gliosis in a rat model of acute ocular hypertension

Wang X, Su J, Ding J, Han S, Ma W, Luo H, Hughes G, Meng Z, Yin Y, Wang Y, Li J

Drug Design, Development and Therapy 2016, 10:3449-3457

Published Date: 20 October 2016

Diminazene aceturate: an antibacterial agent for Shiga-toxin-producing Escherichia coli O157:H7

Wu SY, Park GY, Kim SH, Hulme J, An SSA

Drug Design, Development and Therapy 2016, 10:3363-3378

Published Date: 14 October 2016

Development of a microparticle-based dry powder inhalation formulation of ciprofloxacin hydrochloride applying the quality by design approach

Karimi K, Pallagi E, Szabó-Révész P, Csóka I, Ambrus R

Drug Design, Development and Therapy 2016, 10:3331-3343

Published Date: 12 October 2016

The expression of HoxB5 and SPC in neonatal rat lung at exposure to fluoxetine

Taghizadeh R, Taghipour Z, Karimi A, Shamsizadeh A, Taghavi MM, Shariati M, Shabanizadeh A, Jafari Naveh HR, Bidaki R, Aminzadeh F

Drug Design, Development and Therapy 2016, 10:3323-3329

Published Date: 2 November 2016

Moringin activates Wnt canonical pathway by inhibiting GSK3β in a mouse model of experimental autoimmune encephalomyelitis

Giacoppo S, Soundara Rajan T, De Nicola GR, Iori R, Bramanti P, Mazzon E

Drug Design, Development and Therapy 2016, 10:3291-3304

Published Date: 4 October 2016

Stability of apomorphine in solutions containing selected antioxidant agents

Ang ZY, Boddy M, Liu Y, Sunderland B

Drug Design, Development and Therapy 2016, 10:3253-3265

Published Date: 3 October 2016

Homology modeling, molecular dynamics, and virtual screening of NorA efflux pump inhibitors of Staphylococcus aureus

Bhaskar BV, Babu TMC, Reddy NV, Rajendra W

Drug Design, Development and Therapy 2016, 10:3237-3252

Published Date: 3 October 2016

Druggability analysis and classification of protein tyrosine phosphatase active sites

Ghattas MA, Raslan N, Sadeq A, Al Sorkhy M, Atatreh N

Drug Design, Development and Therapy 2016, 10:3197-3209

Published Date: 30 September 2016

Looking for inhibitors of the dengue virus NS5 RNA-dependent RNA-polymerase using a molecular docking approach

Galiano V, Garcia-Valtanen P, Micol V, Encinar JA

Drug Design, Development and Therapy 2016, 10:3163-3181

Published Date: 11 October 2016

Incidence and risk of hepatic toxicities with PD-1 inhibitors in cancer patients: a meta-analysis

Zhang X, Ran Y, Wang K, Zhu Y, Li J

Drug Design, Development and Therapy 2016, 10:3153-3161

Published Date: 28 September 2016

Resolvins and aliamides: lipid autacoids in ophthalmology – what promise do they hold?

Hesselink JMK, Chiosi F, Costagliola C

Drug Design, Development and Therapy 2016, 10:3133-3141

Published Date: 27 September 2016

Pharmacokinetics, absorption, and excretion of radiolabeled revexepride: a Phase I clinical trial using a microtracer and accelerator mass spectrometry-based approach

Flach S, Croft M, Ding J, Budhram R, Pankratz T, Pennick M, Scarfe G, Troy S, Getsy J

Drug Design, Development and Therapy 2016, 10:3125-3132

Published Date: 27 September 2016

Structural insights into the polypharmacological activity of quercetin on serine/threonine kinases

Baby B, Antony P, Al Halabi W, Al Homedi Z, Vijayan R

Drug Design, Development and Therapy 2016, 10:3109-3123

Published Date: 27 September 2016

Spotlight on sirukumab for the treatment of rheumatoid arthritis: the evidence to date

Lazzerini PE, Capecchi PL, Guidelli GM, Selvi E, Acampa M, Laghi-Pasini F

Drug Design, Development and Therapy 2016, 10:3083-3098

Published Date: 26 September 2016

Formononetin, an active compound of Astragalus membranaceus (Fisch) Bunge, inhibits hypoxia-induced retinal neovascularization via the HIF-1α/VEGF signaling pathway

Wu J, Ke X, Ma N, Wang W, Fu W, Zhang H, Zhao M, Gao X, Hao X, Zhang Z

Drug Design, Development and Therapy 2016, 10:3071-3081

Published Date: 23 September 2016

Efficacy of an acquainted drug in the treatment of inflammatory low back pain: sulfasalazine under investigation

Moghimi J, Rezaei AA, Ghorbani R, Razavi MR, Pahlevan D

Drug Design, Development and Therapy 2016, 10:3065-3069

Published Date: 23 September 2016

TopBP1 contributes to the chemoresistance in non-small cell lung cancer through upregulation of p53

Lv Y, Huo Y, Yu X, Liu R, Zhang S, Zheng X, Zhang X

Drug Design, Development and Therapy 2016, 10:3053-3064

Published Date: 23 September 2016

Controlled release of TGF-beta 1 from RADA self-assembling peptide hydrogel scaffolds

Zhou A, Chen S, He B, Zhao W, Chen X, Jiang D

Drug Design, Development and Therapy 2016, 10:3043-3051

Published Date: 22 September 2016

Effect of low dose of intrathecal pethidine on the incidence and intensity of shivering during cesarean section under spinal anesthesia: a randomized, placebo-controlled, double-blind clinical trial

Shami S, Nasseri K, Shirmohammadi M, Sarshivi F, Ghadami N, Ghaderi E, Pouladi M, Barzanji A

Drug Design, Development and Therapy 2016, 10:3005-3012

Published Date: 20 September 2016

Profile of adalimumab and its potential in the treatment of uveitis

Balevic SJ, Rabinovich CE

Drug Design, Development and Therapy 2016, 10:2997-3003

Published Date: 19 September 2016

Radiolabeled tirofiban – a potential radiopharmaceutical for detection of deep venous thrombosis

Darkovska-Serafimovska M, Janevik-Ivanovska E, Djorgoski I, Arsova-Sarafinovska Z, Zdravkovska M, Balkanov T, Ugresic N

Drug Design, Development and Therapy 2016, 10:2989-2996

Published Date: 21 September 2016

Combined computational and experimental studies of molecular interactions of albuterol sulfate with bovine serum albumin for pulmonary drug nanoparticles

Lin SH, Cui W, Wang GL, Meng S, Liu YC, Jin HW, Zhang LR, Xie Y

Drug Design, Development and Therapy 2016, 10:2973-2987

Published Date: 15 September 2016

Application of physiologically based pharmacokinetic modeling in predicting drug–drug interactions for sarpogrelate hydrochloride in humans

Min JS, Kim D, Park JB, Heo H, Bae SH, Seo JH, Oh E, Bae SK

Drug Design, Development and Therapy 2016, 10:2959-2972

Published Date: 14 September 2016

A triazole derivative elicits autophagic clearance of polyglutamine aggregation in neuronal cells

Hsieh CH, Lee LC, Leong WY, Yang TC, Yao CF, Fang K

Drug Design, Development and Therapy 2016, 10:2947-2957

Published Date: 14 September 2016

Effects of low-carbohydrate diet therapy in overweight subject with autoimmune thyroiditis: possible synergism with ChREBP

Esposito T, Lobaccaro JM, Esposito MG, Monda V, Messina A, Paolisso G, Varriale B, Monda M, Messina G

Drug Design, Development and Therapy 2016, 10:2939-2946

Published Date: 14 September 2016

Protein kinase C–mediated sodium glucose transporter 1 activation in precondition-induced cardioprotection

Kanwal A, Kasetti S, Putcha UK, Asthana S, Banerjee SK

Drug Design, Development and Therapy 2016, 10:2929-2938

Published Date: 14 September 2016

Effects of an immunosuppressive treatment on the rat prostate

Grabowska M, Kędzierska K, Michałek K, Słuczanowska-Głąbowska S, Grabowski M, Piasecka M, Kram A, Rotter I, Rył A, Laszczyńska M

Drug Design, Development and Therapy 2016, 10:2899-2915

Published Date: 12 September 2016

Understanding cytoskeleton regulators in glioblastoma multiforme for therapy design

Masoumi S, Harisankar A, Gracias A, Bachinger F, Fufa T, Chandrasekar G, Gaunitz F, Walfridsson J, Kitambi SS

Drug Design, Development and Therapy 2016, 10:2881-2897

Published Date: 12 September 2016

Synthesis, solubility, plasma stability, and pharmacological evaluation of novel sulfonylhydrazones designed as anti-diabetic agents

Zapata-Sudo G, da Costa Nunes IK, Araujo JSC, da Silva JS, Trachez MM, da Silva TF, da Costa FP, Sudo RT, Barreiro EJ, Lima LM

Drug Design, Development and Therapy 2016, 10:2869-2879

Published Date: 9 September 2016

In situ delivery of thermosensitive gel-mediated 5-fluorouracil microemulsion for the treatment of colorectal cancer

Wang LL, Huang S, Guo HH, Han YX, Zheng WS, Jiang JD

Drug Design, Development and Therapy 2016, 10:2855-2867

Published Date: 8 September 2016

Downregulation of DOCK1 sensitizes bladder cancer cells to cisplatin through preventing epithelial–mesenchymal transition

Chen D, Chen W, Jiang H, Yang H, Wang Y, Chen J

Drug Design, Development and Therapy 2016, 10:2845-2853

Published Date: 8 September 2016

Eltrombopag for the treatment of aplastic anemia: current perspectives

Lum SH, Grainger JD

Drug Design, Development and Therapy 2016, 10:2833-2843

Published Date: 13 September 2016

Development and in vitro characterization of poly(lactide-co-glycolide) microspheres loaded with an antibacterial natural drug for the treatment of long-term bacterial infections

Reinbold J, Hierlemann T, Hinkel H, Müller I, Maier ME, Weindl T, Schlensak C, Wendel HP, Krajewski S,

Drug Design, Development and Therapy 2016, 10:2823-2832

Published Date: 7 September 2016

Intranasal administration of elastin-like polypeptide for therapeutic delivery to the central nervous system

McGowan JWD, Shao Q, Vig PJS, Bidwell III GL

Drug Design, Development and Therapy 2016, 10:2803-2813

Published Date: 6 September 2016

The use of misoprostol for cervical priming prior to hysteroscopy: a systematic review and analysis

Hua Y, Zhang W, Hu X, Yang A, Zhu X

Drug Design, Development and Therapy 2016, 10:2789-2801

Published Date: 6 September 2016

Two Phase II randomized trials on the CRTh2 antagonist AZD1981 in adults with asthma

Kuna P, Bjermer L, Tornling G

Drug Design, Development and Therapy 2016, 10:2759-2770

Published Date: 31 August 2016

Anti-inflammatory drugs for Duchenne muscular dystrophy: focus on skeletal muscle-releasing factors

Miyatake S, Shimizu-Motohashi Y, Takeda S, Aoki Y

Drug Design, Development and Therapy 2016, 10:2745-2758

Published Date: 30 August 2016

Chloroquine improves left ventricle diastolic function in streptozotocin-induced diabetic mice

Yuan X, Xiao YC, Zhang GP, Hou N, Wu XQ, Chen WL, Luo JD, Zhang GS

Drug Design, Development and Therapy 2016, 10:2729-2737

Published Date: 30 August 2016

Clinical study in genital herpes: natural Gene-Eden-VIR/Novirin versus acyclovir, valacyclovir, and famciclovir

Polansky H, Javaherian A, Itzkovitz E

Drug Design, Development and Therapy 2016, 10:2713-2722

Published Date: 29 August 2016

Nanomedical strategy to prolong survival period, heighten cure rate, and lower systemic toxicity of S180 mice treated with MTX/MIT

Song N, Zhao M, Wang Y, Hu X, Wu J, Jiang X, Li S, Cui C, Peng S

Drug Design, Development and Therapy 2016, 10:2701-2711

Published Date: 30 August 2016

Ticagrelor promotes atherosclerotic plaque stability in a mouse model of advanced atherosclerosis

Preusch MR, Rusnak J, Staudacher K, Mogler C, Uhlmann L, Sievers P, Bea F, Katus HA, Blessing E, Staudacher I

Drug Design, Development and Therapy 2016, 10:2691-2699

Published Date: 26 August 2016

Design, synthesis, and characterization of (1-(4-aryl)-1H-1,2,3-triazol-4-yl)methyl, substituted phenyl-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylates against Mycobacterium tuberculosis

Venugopala KN, Dharma Rao GB, Bhandary S, Pillay M, Chopra D, Aldhubiab BE, Attimarad M, Alwassil OI, Harsha S, Mlisana K

Drug Design, Development and Therapy 2016, 10:2681-2690

Published Date: 25 August 2016

Development of betulinic acid as an agonist of TGR5 receptor using a new in vitro assay

Lo SH, Cheng KC, Li YX, Chang CH, Cheng JT, Lee KS

Drug Design, Development and Therapy 2016, 10:2669-2676

Published Date: 22 August 2016

Effects of alprostadil and iloprost on renal, lung, and skeletal muscle injury following hindlimb ischemia–reperfusion injury in rats

Erer D, Özer A, Demirtaş H, Gönül İI, Kara H, Arpacı H, Çomu FM, Oktar GL, Arslan M, Küçük A

Drug Design, Development and Therapy 2016, 10:2651-2658

Published Date: 19 August 2016

Pharmacokinetic profile of defibrotide in patients with renal impairment

Tocchetti P, Tudone E, Marier JF, Marbury TC, Zomorodi K, Eller M

Drug Design, Development and Therapy 2016, 10:2631-2641

Published Date: 16 August 2016

Novel glyoxalase-I inhibitors possessing a “zinc-binding feature” as potential anticancer agents

Al-Balas QA, Hassan MA, Al-Shar’i NA, Mhaidat NM, Almaaytah AM, Al-Mahasneh FM, Isawi IH

Drug Design, Development and Therapy 2016, 10:2623-2629

Published Date: 17 August 2016

Construction of p66Shc gene interfering lentivirus vectors and its affections on alveolar epithelial cells apoptosis induced by hyperoxia

Zhang C, Dong WB, Zhao S, Li QP, Kang L, Lei XP, Guo L, Zhai XS

Drug Design, Development and Therapy 2016, 10:2611-2622

Published Date: 16 August 2016

Design and characteristics of cytotoxic fibroblast growth factor 1 conjugate for fibroblast growth factor receptor-targeted cancer therapy

Szlachcic A, Zakrzewska M, Lobocki M, Jakimowicz P, Otlewski J

Drug Design, Development and Therapy 2016, 10:2547-2560

Published Date: 9 August 2016

Effects of salvianolate on bone metabolism in glucocorticoid-treated lupus-prone B6.MRL-Faslpr/J mice

Liu Y, Cui Y, Zhang X, Gao X, Su Y, Xu B, Wu T, Chen W, Cui L

Drug Design, Development and Therapy 2016, 10:2535-2546

Published Date: 9 August 2016

Pharmacokinetic and pharmacodynamic interactions between metformin and a novel dipeptidyl peptidase-4 inhibitor, evogliptin, in healthy subjects

Rhee SJ, Choi Y, Lee S, Oh J, Kim SJ, Yoon SH, Cho JY, Yu KS

Drug Design, Development and Therapy 2016, 10:2525-2534

Published Date: 10 August 2016

NAD(P)H:quinone oxidoreductase 1 inducer activity of some novel anilinoquinazoline derivatives

Ghorab MM, Alsaid MS, Higgins M, Dinkova-Kostova AT, Shahat AA, Elghazawy NH, Arafa RK

Drug Design, Development and Therapy 2016, 10:2515-2524

Published Date: 8 August 2016

Endoplasmic reticulum stress-induced autophagy determines the susceptibility of melanoma cells to dabrafenib

Ji C, Zhang ZP, Chen LH, Zhou KL, Li DJ, Wang P, Huang SY, Gong T, Cheng B

Drug Design, Development and Therapy 2016, 10:2491-2498

Published Date: 4 August 2016

Metformin increases pressure pain threshold in lean women with polycystic ovary syndrome

Kiałka M, Milewicz T, Sztefko K, Rogatko I, Majewska R

Drug Design, Development and Therapy 2016, 10:2483-2490

Published Date: 3 August 2016

Effects of lornoxicam and intravenous ibuprofen on erythrocyte deformability and hepatic and renal blood flow in rats

Arpacı H, Çomu FM, Küçük A, Kösem B, Kartal S, Şıvgın V, Turgut HC, Aydın ME, Koç DS, Arslan M

Drug Design, Development and Therapy 2016, 10:2477-2481

Published Date: 3 August 2016

Design of a nanostructured lipid carrier intended to improve the treatment of tuberculosis

Pinheiro M, Ribeiro R, Vieira A, Andrade F, Reis S

Drug Design, Development and Therapy 2016, 10:2467-2475

Published Date: 2 August 2016

Receptor tyrosine kinase (c-Kit) inhibitors: a potential therapeutic target in cancer cells

Abbaspour Babaei M, Kamalidehghan B, Saleem M, Huri HZ, Ahmadipour F

Drug Design, Development and Therapy 2016, 10:2443-2459

Published Date: 1 August 2016

The role of CD147 expression in prostate cancer: a systematic review and meta-analysis

Ye Y, Li SL, Wang Y, Yao Y, Wang J, Ma YY, Hao XK

Drug Design, Development and Therapy 2016, 10:2435-2442

Published Date: 1 August 2016

Flurbiprofen–antioxidant mutual prodrugs as safer nonsteroidal anti-inflammatory drugs: synthesis, pharmacological investigation, and computational molecular modeling

Ashraf Z, Alamgeer, Kanwal M, Hassan M, Abdullah S, Waheed M, Ahsan H, Kim SJ

Drug Design, Development and Therapy 2016, 10:2401-2419

Published Date: 27 July 2016

A review of omalizumab for the management of severe asthma

Lin CH, Cheng SL

Drug Design, Development and Therapy 2016, 10:2369-2378

Published Date: 26 July 2016

Distinct role of the Fas rs1800682 and FasL rs763110 polymorphisms in determining the risk of breast cancer among Han Chinese women

Wang M, Wang Z, Wang XJ, Jin TB, Dai ZM, Kang HF, Guan HT, Ma XB, Liu XH, Dai ZJ

Drug Design, Development and Therapy 2016, 10:2359-2367

Published Date: 25 July 2016

Paclitaxel plus valproic acid versus paclitaxel alone as second- or third-line therapy for advanced gastric cancer: a randomized Phase II trial

Fushida S, Kinoshita J, Kaji M, Oyama K, Hirono Y, Tsukada T, Fujimura T, Ohta T

Drug Design, Development and Therapy 2016, 10:2353-2358

Published Date: 25 July 2016

Novel A20-gene-eluting stent inhibits carotid artery restenosis in a porcine model

Zhou ZH, Peng J, Meng ZY, Chen L, Huang JL, Huang HQ, Li L, Zeng W, Wei Y, Zhu CH, Chen KN

Drug Design, Development and Therapy 2016, 10:2341-2351

Published Date: 8 August 2016

Voiding dysfunction in patients with nasal congestion treated with pseudoephedrine: a prospective study

Shao IH, Wu CC, Tseng HJ, Lee TJ, Lin YH, Tam YY

Drug Design, Development and Therapy 2016, 10:2333-2339

Published Date: 19 July 2016

Prediction of selective estrogen receptor beta agonist using open data and machine learning approach

Niu AQ, Xie LJ, Wang H, Zhu B, Wang SQ

Drug Design, Development and Therapy 2016, 10:2323-2331

Published Date: 18 July 2016

SPOCK1 promotes tumor growth and metastasis in human prostate cancer

Chen Q, Yao YT, Xu H, Chen YB, Gu M, Cai ZK, Wang Z

Drug Design, Development and Therapy 2016, 10:2311-2321

Published Date: 18 July 2016

Rational design and synthesis of novel diphenyl ether derivatives as antitubercular agents

Kar SS, Bhat G V, Rao PP, Shenoy VP, Bairy I, Shenoy GG

Drug Design, Development and Therapy 2016, 10:2299-2310

Published Date: 18 July 2016

Galeterone for the treatment of advanced prostate cancer: the evidence to date

Bastos DA, Antonarakis ES

Drug Design, Development and Therapy 2016, 10:2289-2297

Published Date: 15 July 2016

The influence of intrauterine exposure to immunosuppressive treatment on changes in the immune system in juvenile Wistar rats

Kabat-Koperska J, Kolasa-Wołosiuk A, Wojciuk B, Wojciechowska-Koszko I, Roszkowska P, Krasnodębska-Szponder B, Paczkowska E, Safranow K, Gołembiewska E, Machaliński B, Ciechanowski K

Drug Design, Development and Therapy 2016, 10:2279-2288

Published Date: 14 July 2016

Simvastatin attenuates radiation-induced salivary gland dysfunction in mice

Xu L, Yang X, Chen J, Ge X, Qin Q, Zhu H, Zhang C, Sun X

Drug Design, Development and Therapy 2016, 10:2271-2278

Published Date: 13 July 2016

Thymoquinone subdues tumor growth and potentiates the chemopreventive effect of 5-fluorouracil on the early stages of colorectal carcinogenesis in rats

Kensara OA, El-Shemi AG, Mohamed AM, Refaat B, Idris S, Ahmad J

Drug Design, Development and Therapy 2016, 10:2239-2253

Published Date: 11 July 2016

Pharmacogenetic analysis of cinacalcet response in secondary hyperparathyroidism patients

Jeong S, Kim IW, Oh KH, Han N, Joo KW, Kim HJ, Oh JM

Drug Design, Development and Therapy 2016, 10:2211-2225

Published Date: 8 July 2016

Acyl lipidation of a peptide: effects on activity and epidermal permeability in vitro

Rocco D, Ross J, Murray PE, Caccetta R

Drug Design, Development and Therapy 2016, 10:2203-2209

Published Date: 8 July 2016

Rosmarinic acid ameliorates hyperglycemia and insulin sensitivity in diabetic rats, potentially by modulating the expression of PEPCK and GLUT4

Runtuwene J, Cheng KC, Asakawa A, Amitani H, Amitani M, Morinaga A, Takimoto Y, Kairupan BHR, Inui A

Drug Design, Development and Therapy 2016, 10:2193-2202

Published Date: 7 July 2016

Effect of N-methyl deuteration on metabolism and pharmacokinetics of enzalutamide

Jiang J, Pang X, Li L, Dai X, Diao X, Chen X, Zhong D, Wang Y, Chen Y

Drug Design, Development and Therapy 2016, 10:2181-2191

Published Date: 7 July 2016

The effects of ferulic acid on the pharmacokinetics of warfarin in rats after biliary drainage

Li H, Wang Y, Fan R, Lv H, Sun H, Xie H, Tang T, Luo J, Xia Z

Drug Design, Development and Therapy 2016, 10:2173-2180

Published Date: 6 July 2016

Cabozantinib in the treatment of advanced renal cell carcinoma: design, development, and potential place in the therapy

Grassi P, Verzoni E, Ratta R, Mennitto A, de Braud F, Procopio G

Drug Design, Development and Therapy 2016, 10:2167-2172

Published Date: 5 July 2016

Real-time monitoring of cisplatin cytotoxicity on three-dimensional spheroid tumor cells

Baek NH, Seo OW, Lee J, Hulme J, An SSA

Drug Design, Development and Therapy 2016, 10:2155-2165

Published Date: 4 July 2016

Pharmacophore modeling and in silico toxicity assessment of potential anticancer agents from African medicinal plants

Ntie-Kang F, Simoben CV, Karaman B, Ngwa VF, Judson PN, Sippl W, Mbaze LM

Drug Design, Development and Therapy 2016, 10:2137-2154

Published Date: 4 July 2016

Clinical implications for substandard, nonproprietary medicines in multiple sclerosis: focus on fingolimod

Correale J, Chiquete E, Boyko A, Beran RG, Strauch JB, Milojevic S, Frider N

Drug Design, Development and Therapy 2016, 10:2109-2117

Published Date: 30 June 2016

Sitagliptin attenuates cardiomyopathy by modulating the JAK/STAT signaling pathway in experimental diabetic rats

Al-Rasheed NM, Al-Rasheed NM, Hasan IH, Al-Amin MA, Al-Ajmi HN, Mahmoud AM

Drug Design, Development and Therapy 2016, 10:2095-2107

Published Date: 28 June 2016

Golimumab in radiographic and nonradiographic axial spondyloarthritis: a review of clinical trials

Toussirot E, Vauchy C, Binda D, Michel F

Drug Design, Development and Therapy 2016, 10:2087-2094

Published Date: 1 July 2016

Dietary arginine silicate inositol complex increased bone healing: histologic and histomorphometric study

Yaman F, Acikan I, Dundar S, Simsek S, Gul M, Ozercan İH, Komorowski J, Sahin K

Drug Design, Development and Therapy 2016, 10:2081-2086

Published Date: 27 June 2016

Secukinumab for rheumatology: development and its potential place in therapy

Koenders MI, van den Berg WB

Drug Design, Development and Therapy 2016, 10:2069-2080

Published Date: 24 June 2016

The cytotoxicity study of praziquantel enantiomers

Sun Q, Mao RF, Wang DL, Hu CY, Zheng Y, Sun DQ

Drug Design, Development and Therapy 2016, 10:2061-2068

Published Date: 24 June 2016

Anti-dengue drug: viral polyprotein, a potential target

Mahmood SU, Mushtaq M, Syed MJ

Drug Design, Development and Therapy 2016, 10:2047-2048

Published Date: 24 June 2016

Fondaparinux vs warfarin for the treatment of unsuspected pulmonary embolism in cancer patients

Amato B, Compagna R, Rocca A, Bianco T, Milone M, Sivero L, Vigliotti G, Amato M, Danzi M, Aprea G, Gallelli L, de Franciscis S, Serra R

Drug Design, Development and Therapy 2016, 10:2041-2046

Published Date: 23 June 2016

A novel pH–enzyme-dependent mesalamine colon-specific delivery system

Jin L, Ding Y, Zhang Y, Xu X, Cao Q

Drug Design, Development and Therapy 2016, 10:2021-2028

Published Date: 20 June 2016

MART-10, a newly synthesized vitamin D analog, represses metastatic potential of head and neck squamous carcinoma cells

Yang SW, Tsai CY, Pan YC, Yeh CN, Pang JHS, Takano M, Kittaka A, Juang HH, Chen TC, Chiang KC

Drug Design, Development and Therapy 2016, 10:1995-2002

Published Date: 17 June 2016

Double-blind, randomized, double-dummy clinical trial comparing the efficacy of ketorolac trometamol and naproxen for acute low back pain

Plapler PG, Scheinberg MA, Ecclissato CC, Bocchi de Oliveira MF, Amazonas RB

Drug Design, Development and Therapy 2016, 10:1987-1993

Published Date: 17 June 2016

Prophylactic effects of Clausena excavata Burum. f. leaf extract in ethanol-induced gastric ulcers

Albaayit SFA, Abba Y, Abdullah R, Abdullah N

Drug Design, Development and Therapy 2016, 10:1973-1986

Published Date: 15 June 2016

Efficacy and safety of gemcitabine plus erlotinib for locally advanced or metastatic pancreatic cancer: a systematic review and meta-analysis

Wang Y, Hu GF, Zhang QQ, Tang N, Guo J, Liu LY, Han X, Wang X, Wang ZH

Drug Design, Development and Therapy 2016, 10:1961-1972

Published Date: 13 June 2016

A novel imidazopyridine derivative, X22, attenuates sepsis-induced lung and liver injury by inhibiting the inflammatory response in vitro and in vivo

Ge X, Feng Z, Xu T, Wu B, Chen H, Xu F, Fu L, Shan X, Dai Y, Zhang Y, Liang G

Drug Design, Development and Therapy 2016, 10:1947-1959

Published Date: 24 June 2016

The efficacy of nebulized magnesium sulfate alone and in combination with salbutamol in acute asthma

Sarhan HA, EL-Garhy OH, Ali MA, Youssef NA

Drug Design, Development and Therapy 2016, 10:1927-1933

Published Date: 9 June 2016

In vivo gastric residence and gastroprotective effect of floating gastroretentive tablet of DA-9601, an extract of Artemisia asiatica, in beagle dogs

Kim JS, Cha KH, Kang SY, Won D, Jang SW, Son M, Son MH, Choi HJ, Lee YW, Kang MJ

Drug Design, Development and Therapy 2016, 10:1917-1925

Published Date: 9 June 2016

Role of cytochrome P450 2D6 genetic polymorphism in carvedilol hydroxylation in vitro

Wang Z, Wang L, Xu RA, Zhan YY, Huang CK, Dai DP, Cai JP, Hu GX

Drug Design, Development and Therapy 2016, 10:1909-1916

Published Date: 8 June 2016

Flavokawain derivative FLS induced G2/M arrest and apoptosis on breast cancer MCF-7 cell line

Ali NM, Akhtar MN, Ky H, Lim KL, Abu N, Zareen S, Ho WY, Alan-Ong HK, Tan SW, Alitheen NB, Ismail JB, Yeap SK, Kamarul T

Drug Design, Development and Therapy 2016, 10:1897-1907

Published Date: 10 June 2016

Molecular mechanisms of cisplatin resistance in cervical cancer

Zhu H, Luo H, Zhang W, Shen Z, Hu X, Zhu X

Drug Design, Development and Therapy 2016, 10:1885-1895

Published Date: 7 June 2016

Erythropoietin ameliorates hyperglycemia in type 1-like diabetic rats

Niu HS, Chang CH, Niu CS, Cheng JT, Lee KS

Drug Design, Development and Therapy 2016, 10:1877-1884

Published Date: 3 June 2016

Indigofera oblongifolia mitigates lead-acetate-induced kidney damage and apoptosis in a rat model

Dkhil MA, Al-Khalifa MS, Al-Quraishy S, Zrieq R, Abdel Moneim AE

Drug Design, Development and Therapy 2016, 10:1847-1856

Published Date: 2 June 2016

Nelfinavir is effective against human cervical cancer cells in vivo: a potential treatment modality in resource-limited settings

Davis MA, Delaney JR, Patel CB, Storgard R, Stupack DG

Drug Design, Development and Therapy 2016, 10:1837-1846

Published Date: 2 June 2016

Synthesis, activity, and docking study of phenylthiazole acids as potential agonists of PPARγ

Ma L, Wang T, Shi M, Ye H

Drug Design, Development and Therapy 2016, 10:1807-1815

Published Date: 30 May 2016

The arsenal of pathogens and antivirulence therapeutic strategies for disarming them

Brannon JR, Hadjifrangiskou M

Drug Design, Development and Therapy 2016, 10:1795-1806

Published Date: 27 May 2016

An open-label clinical trial of agalsidase alfa enzyme replacement therapy in children with Fabry disease who are naïve to enzyme replacement therapy

Goker-Alpan O, Longo N, McDonald M, Shankar SP, Schiffmann R, Chang P, Shen Y, Pano A

Drug Design, Development and Therapy 2016, 10:1771-1781

Published Date: 25 May 2016

Apremilast in the therapy of moderate-to-severe chronic plaque psoriasis

Gisondi P, Girolomoni G

Drug Design, Development and Therapy 2016, 10:1763-1770

Published Date: 25 May 2016

Activity of a novel sulfonamide compound 2-nitro-N-(pyridin-2-ylmethyl)benzenesulfonamide against Leishmania donovani

Dikhit MR, Purkait B, Singh R, Sahoo BR, Kumar A, Kar RK, Ansari MY, Saini S, Abhishek K, Sahoo GC, Das S, Das P

Drug Design, Development and Therapy 2016, 10:1753-1761

Published Date: 26 May 2016

Computer-aided vaccine designing approach against fish pathogens Edwardsiella tarda and Flavobacterium columnare using bioinformatics softwares

Mahendran R, Jeyabaskar S, Sitharaman G, Michael RD, Paul AV

Drug Design, Development and Therapy 2016, 10:1703-1714

Published Date: 23 May 2016

Electroporation-delivered transdermal neostigmine in rats: equivalent action to intravenous administration

Berkó S, Szűcs KF, Balázs B, Csányi E, Varju G, Sztojkov-Ivanov A, Budai-Szűcs M, Bóta J, Gáspár R

Drug Design, Development and Therapy 2016, 10:1695-1701

Published Date: 19 May 2016

Safety, tolerability, pharmacokinetics, and pharmacodynamics of novel glucokinase activator HMS5552: results from a first-in-human single ascending dose study

Xu HR, Sheng L, Chen WL, Yuan F, Yang MJ, Li H, Li XN, Choi J, Zhao GY, Hu TX, Li YG, Zhang Y, Chen L

Drug Design, Development and Therapy 2016, 10:1619-1626

Published Date: 9 May 2016

Effectiveness, durability, and safety of darunavir/ritonavir in HIV-1-infected patients in routine clinical practice in Italy: a postauthorization noninterventional study

Antinori A, Meraviglia P, d’Arminio Monforte A, Castagna A, Mussini C, Bini T, Gianotti N, Rusconi S, Colella E, Airoldi G, Mancusi D, Termini R

Drug Design, Development and Therapy 2016, 10:1589-1603

Published Date: 6 May 2016

Fimasartan for independent reduction of blood pressure variability in mild-to-moderate hypertension

Shin MS, Kang DR, Kim C, Cho EJ, Sung KC, Kang SM, Kim DS, Joo SJ, Lee SH, Hwang KK, Park JB

Drug Design, Development and Therapy 2016, 10:1573-1580

Published Date: 5 May 2016

Fungistatic activity of all-trans retinoic acid against Aspergillus fumigatus and Candida albicans

Campione E, Gaziano R, Marino D, Orlandi A

Drug Design, Development and Therapy 2016, 10:1551-1555

Published Date: 29 April 2016

Zolav®: a new antibiotic for the treatment of acne [Corrigendum]

Dinant A, Boulos RA

Drug Design, Development and Therapy 2016, 10:1549-1550

Published Date: 29 April 2016

Efficacy and safety of different doses of a slow-release corticosteroid implant for macular edema [Corrigendum]

Liu QY, He MM, Shi H, Wang QY, Du YR, Liu JL, Ren CD, Xu D, Yu J

Drug Design, Development and Therapy 2016, 10:1547-1548

Published Date: 27 April 2016

The influence of dietary sodium content on the pharmacokinetics and pharmacodynamics of fimasartan

Gu N, Cho JY, Shin KH, Jang IJ, Rhee MY

Drug Design, Development and Therapy 2016, 10:1525-1531

Published Date: 19 April 2016

Autophagy inhibition enhances RAD001-induced cytotoxicity in human bladder cancer cells

Lin JF, Lin YC, Yang SC, Tsai TF, Chen HE, Chou KY, Hwang TIS

Drug Design, Development and Therapy 2016, 10:1501-1513

Published Date: 18 April 2016

Design, synthesis, and biological evaluation of 3-vinyl-quinoxalin-2(1H)-one derivatives as novel antitumor inhibitors of FGFR1

Liu Z, Yu S, Chen D, Shen G, Wang Y, Hou L, Lin D, Zhang JS, Ye F

Drug Design, Development and Therapy 2016, 10:1489-1500

Published Date: 3 May 2016

Neuroprotective effect of β-asarone against Alzheimer’s disease: regulation of synaptic plasticity by increased expression of SYP and GluR1

Liu SJ, Yang C, Zhang Y, Su RY, Chen JL, Jiao MM, Chen HF, Zheng N, Luo S, Chen YB, Quan SJ, Wang Q

Drug Design, Development and Therapy 2016, 10:1461-1469

Published Date: 15 April 2016

Zoledronate upregulates MMP-9 and -13 in rat vascular smooth muscle cells by inducing oxidative stress

Arun MZ, Reel B, Sala-Newby GB, Bond M, Tsaousi A, Maskell P, Newby AC

Drug Design, Development and Therapy 2016, 10:1453-1460

Published Date: 18 April 2016

Xyloketal-derived small molecules show protective effect by decreasing mutant Huntingtin protein aggregates in Caenorhabditis elegans model of Huntington’s disease

Zeng YX, Guo WY, Xu GQ, Wang QM, Feng LY, Long SM, Liang FY, Huang Y, Lu XL, Li SC, Zhou JB, Burgunder JM, Pang JY, Pei Z

Drug Design, Development and Therapy 2016, 10:1443-1451

Published Date: 13 April 2016

Baicalein suppresses metastasis of breast cancer cells by inhibiting EMT via downregulation of SATB1 and Wnt/β-catenin pathway

Ma X, Yan W, Dai Z, Gao X, Ma Y, Xu Q, Jiang J, Zhang S

Drug Design, Development and Therapy 2016, 10:1419-1441

Published Date: 18 April 2016

Functionalized D-form self-assembling peptide hydrogels for bone regeneration

He B, Ou Y, Zhou A, Chen S, Zhao W, Zhao J, Li H, Zhu Y, Zhao Z, Jiang D

Drug Design, Development and Therapy 2016, 10:1379-1388

Published Date: 11 April 2016

Neuroprotective effects of salidroside through PI3K/Akt pathway activation in Alzheimer’s disease models

Zhang B, Wang Y, Li H, Xiong R, Zhao Z, Chu X, Li Q, Sun S, Chen S

Drug Design, Development and Therapy 2016, 10:1335-1343

Published Date: 6 April 2016

Identification of new drug candidates against Borrelia burgdorferi using high-throughput screening

Pothineni VR, Wagh D, Babar MM, Inayathullah M, Solow-Cordero DE, Kim KM, Samineni AV, Parekh MB, Tayebi L, Rajadas J

Drug Design, Development and Therapy 2016, 10:1307-1322

Published Date: 1 April 2016

In vitro and in vivo efficacy of afatinib as a single agent or in combination with gemcitabine for the treatment of nasopharyngeal carcinoma

Xue C, Tian Y, Zhang J, Zhao YY, Zhan JH, Fang WF, Zhang L

Drug Design, Development and Therapy 2016, 10:1299-1306

Published Date: 31 March 2016

Curcumin protects against myocardial infarction-induced cardiac fibrosis via SIRT1 activation in vivo and in vitro

Xiao J, Sheng X, Zhang X, Guo M, Ji X

Drug Design, Development and Therapy 2016, 10:1267-1277

Published Date: 29 March 2016

Comparative efficacy of tamsulosin versus nifedipine for distal ureteral calculi: a meta-analysis

Wang H, Man LB, Huang GL, Li GZ, Wang JW

Drug Design, Development and Therapy 2016, 10:1257-1265

Published Date: 29 March 2016

Zolav®: a new antibiotic for the treatment of acne

Dinant A, Boulos RA

Drug Design, Development and Therapy 2016, 10:1235-1242

Published Date: 22 March 2016

The renoprotective effects of sulodexide

Olde Engberink RH, Vogt L

Drug Design, Development and Therapy 2016, 10:1233-1234

Published Date: 22 March 2016

Role of glycogen synthase kinase-3β inhibitor AZD1080 in ovarian cancer

Chen S, Sun KX, Feng MX, Sang XB, Liu BL, Zhao Y

Drug Design, Development and Therapy 2016, 10:1225-1232

Published Date: 18 March 2016

Effects of acute and chronic administration of neurosteroid dehydroepiandrosterone sulfate on neuronal excitability in mice

Svob Strac D, Vlainic J, Samardzic J, Erhardt J, Krsnik Z

Drug Design, Development and Therapy 2016, 10:1201-1215

Published Date: 21 March 2016

Computational and nonglycosylated systems: a simpler approach for development of nanosized PEGylated proteins

Mirzaei H, Kazemi B, Bandehpour M, Shoari A, Asgary V, Ardestani MS, Madadkar-Sobhani A, Ahangari Cohan R

Drug Design, Development and Therapy 2016, 10:1193-1200

Published Date: 16 March 2016

Sonodynamic effect of hematoporphyrin monomethyl ether on ligature-induced periodontitis in rats [Corrigendum]

Zhuang DS, Han JL, Bi LJ, Wang YP, Hao YR, Zhou Q, Cao WW

Drug Design, Development and Therapy 2016, 10:1191-1192

Published Date: 17 March 2016

Efficacy of BIBF 1120 or BIBF 1120 plus chemotherapy on nasopharyngeal carcinoma in vitro and in vivo

Xue C, Tian Y, Zhang J, Zhao Y, Zhan J, Fang W, Zhang L

Drug Design, Development and Therapy 2016, 10:1173-1180

Published Date: 15 March 2016

Toward antituberculosis drugs: in silico screening of synthetic compounds against Mycobacterium tuberculosis L,D-transpeptidase 2

Billones JB, Carrillo MCO, Organo VG, Macalino SJY, Sy JBA, Emnacen IA, Clavio NAB, Concepcion GP

Drug Design, Development and Therapy 2016, 10:1147-1157

Published Date: 11 March 2016

Synthesis, antimicrobial, and antiproliferative activities of substituted phenylfuranylnicotinamidines

Youssef MM, Arafa RK, Ismail MA,

Drug Design, Development and Therapy 2016, 10:1133-1146

Published Date: 11 March 2016

Selective use of sorafenib in the treatment of thyroid cancer

Pitoia F, Jerkovich F

Drug Design, Development and Therapy 2016, 10:1119-1131

Published Date: 11 March 2016

Formulation and clinical evaluation of silymarin pluronic-lecithin organogels for treatment of atopic dermatitis

Mady FM, Essa H, El-Ammawi T, Abdelkader H, Hussein AK

Drug Design, Development and Therapy 2016, 10:1101-1110

Published Date: 10 March 2016

Protective effects of honokiol on ischemia/reperfusion injury of rat ovary: an experimental study

Yaman Tunc S, Agacayak E, Goruk NY, Icen MS, Turgut A, Alabalik U, Togrul C, Ekinci C, Ekinci A, Gul T

Drug Design, Development and Therapy 2016, 10:1077-1083

Published Date: 8 March 2016

RGD(F/S/V)-Dex: towards the development of novel, effective, and safe glucocorticoids

Jiang X, Zhao M, Wang Y, Zhu H, Zhao S, Wu J, Song Y, Peng S

Drug Design, Development and Therapy 2016, 10:1059-1076

Published Date: 8 March 2016

Chloroquine enhances the efficacy of cisplatin by suppressing autophagy in human adrenocortical carcinoma treatment

Qin L, Xu TY, Xia LL, Wang XJ, Zhang X, Zhang XH, Zhu ZW, Zhong S, Wang CD, Shen ZJ

Drug Design, Development and Therapy 2016, 10:1035-1045

Published Date: 7 March 2016

Stability studies of lincomycin hydrochloride in aqueous solution and intravenous infusion fluids

Czarniak P, Boddy M, Sunderland B, Hughes JD

Drug Design, Development and Therapy 2016, 10:1029-1034

Published Date: 7 March 2016

Amsacrine analog-loaded solid lipid nanoparticle to resolve insolubility for injection delivery: characterization and pharmacokinetics

Fang YP, Chuang CH, Wu PC, Huang YB, Tzeng CC, Chen YL, Liu YT, Tsai YH, Tsai MJ

Drug Design, Development and Therapy 2016, 10:1019-1028

Published Date: 4 March 2016

Plasmodium-infected erythrocytes (pRBC) induce endothelial cell apoptosis via a heme-mediated signaling pathway

Liu M, Dickinson-Copeland C, Hassana S, Stiles JK

Drug Design, Development and Therapy 2016, 10:1009-1018

Published Date: 3 March 2016

Da0324, an inhibitor of nuclear factor-κB activation, demonstrates selective antitumor activity on human gastric cancer cells

Jin R, Xia Y, Chen Q, Li W, Chen D, Ye H, Zhao C, Du X, Shi D, Wu J, Liang G

Drug Design, Development and Therapy 2016, 10:979-995

Published Date: 2 March 2016

Eucommia bark (Du-Zhong) improves diabetic nephropathy without altering blood glucose in type 1-like diabetic rats

Niu HS, Liu IM, Niu CS, Ku PM, Hsu CT, Cheng JT

Drug Design, Development and Therapy 2016, 10:971-978

Published Date: 2 March 2016

Solubility enhancement of simvastatin by arginine: thermodynamics, solute–solvent interactions, and spectral analysis

Meor Mohd Affandi MMR, Tripathy M, Shah SAA, Majeed ABA

Drug Design, Development and Therapy 2016, 10:959-969

Published Date: 2 March 2016

Effects of Dang-Gui-Bu-Xue-Tang, an herbal decoction, on iron uptake in iron-deficient anemia

Huang GC, Chen SY, Tsai PW, Ganzon JG, Lee CJ, Shiah HS, Wang CC

Drug Design, Development and Therapy 2016, 10:949-957

Published Date: 2 March 2016

Effect of picroside II on erythrocyte deformability and lipid peroxidation in rats subjected to hind limb ischemia reperfusion injury

Çomu FM, Kılıç Y, Özer A, Kirişçi M, Dursun AD, Tatar T, Zor MH, Kartal H, Küçük A, Boyunağa H, Arslan M

Drug Design, Development and Therapy 2016, 10:927-931

Published Date: 1 March 2016

Naringenin-loaded solid lipid nanoparticles: preparation, controlled delivery, cellular uptake, and pulmonary pharmacokinetics

Ji P, Yu T, Liu Y, Jiang J, Xu J, Zhao Y, Hao Y, Qiu Y, Zhao W, Wu C

Drug Design, Development and Therapy 2016, 10:911-925

Published Date: 1 March 2016

The aqueous extract of Glycyrrhiza inflata can upregulate unfolded protein response-mediated chaperones to reduce tau misfolding in cell models of Alzheimer’s disease

Chang KH, Chen IC, Lin HY, Chen HC, Lin CH, Lin TH, Weng YT, Chao CY, Wu YR, Lin JY, Lee-Chen GJ, Chen CM

Drug Design, Development and Therapy 2016, 10:885-896

Published Date: 29 February 2016

Spotlight on lenvatinib in the treatment of thyroid cancer: patient selection and perspectives

Costa R, Carneiro BA, Chandra S, Pai SG, Chae YK, Kaplan JB, Garrett HB, Agulnik M, Kopp PA, Giles FJ

Drug Design, Development and Therapy 2016, 10:873-884

Published Date: 29 February 2016

The interplay of post-translational modification and gene therapy

Osamor VC, Chinedu SN, Azuh DE, Iweala EJ, Ogunlana OO

Drug Design, Development and Therapy 2016, 10:861-871

Published Date: 29 February 2016

Papaverine inhibits lipopolysaccharide-induced microglial activation by suppressing NF-κB signaling pathway

Dang Y, Mu Y, Wang K, Xu K, Yang J, Zhu Y, Luo B

Drug Design, Development and Therapy 2016, 10:851-859

Published Date: 26 February 2016

The mechanism underlying alpinetin-mediated alleviation of pancreatitis-associated lung injury through upregulating aquaporin-1

Liang XS, Zhang B, Chen Q, Zhang J, Lei B, Li B, Wei YC, Zhai R, Liang ZQ, He SQ, Tang B

Drug Design, Development and Therapy 2016, 10:841-850

Published Date: 24 February 2016

Total saponin of Dioscoreae hypoglaucae rhizoma ameliorates streptozotocin-induced diabetic nephropathy

Guo C, Ding G, Huang W, Wang Z, Meng Z, Xiao W

Drug Design, Development and Therapy 2016, 10:799-810

Published Date: 24 February 2016

Synergistic roles of p53 and HIF1α in human renal cell carcinoma-cell apoptosis responding to the inhibition of mTOR and MDM2 signaling pathways

Liu QJ, Shen HL, Lin J, Xu XH, Ji ZG, Han X, Shang DH, Yang PQ

Drug Design, Development and Therapy 2016, 10:745-755

Published Date: 18 February 2016

A network pharmacology approach to discover active compounds and action mechanisms of San-Cao Granule for treatment of liver fibrosis

Wei S, Niu M, Wang J, Wang J, Su H, Luo S, Zhang X, Guo Y, Liu L, Liu F, Zhao Q, Chen H, Xiao X, Zhao P, Zhao Y

Drug Design, Development and Therapy 2016, 10:733-743

Published Date: 19 February 2016

Treatment with a Ginkgo biloba extract, EGb 761, inhibits excitotoxicity in an animal model of spinocerebellar ataxia type 17

Huang DS, Lin HY, Lee-Chen GJ, Hsieh-Li HM, Wu CH, Lin JY

Drug Design, Development and Therapy 2016, 10:723-731

Published Date: 18 February 2016

Effects of 22 novel CYP2D6 variants found in Chinese population on the metabolism of dapoxetine

Xu RA, Gu EM, Zhou Q, Yuan LJ, Hu XX, Cai JP, Hu GX

Drug Design, Development and Therapy 2016, 10:687-696

Published Date: 15 February 2016

Long-term use of amiodarone before heart transplantation significantly reduces early post-transplant atrial fibrillation and is not associated with increased mortality after heart transplantation

Rivinius R, Helmschrott M, Ruhparwar A, Schmack B, Erbel C, Gleissner CA, Akhavanpoor M, Frankenstein L, Darche FF, Schweizer PA, Thomas D, Ehlermann P, Bruckner T, Katus HA, Doesch AO

Drug Design, Development and Therapy 2016, 10:677-686

Published Date: 16 February 2016

Drug-loaded erythrocytes: on the road toward marketing approval

Bourgeaux V, Lanao JM, Bax BE, Godfrin Y

Drug Design, Development and Therapy 2016, 10:665-676

Published Date: 11 February 2016

Therapeutic effects of tyroservatide on metastasis of lung cancer and its mechanism affecting integrin–focal adhesion kinase signal transduction

Huang YT, Zhao L, Fu Z, Zhao M, Song XM, Jia J, Wang S, Li JP, Zhu ZF, Lin G, Lu R, Yao Z

Drug Design, Development and Therapy 2016, 10:649-663

Published Date: 3 March 2016

Epigallocatechin-3-gallate attenuates apoptosis and autophagy in concanavalin A-induced hepatitis by inhibiting BNIP3

Li S, Xia Y, Chen K, Li J, Liu T, Wang F, Lu J, Zhou Y, Guo C

Drug Design, Development and Therapy 2016, 10:631-647

Published Date: 15 February 2016

Protective effect of fucoidan from Fucus vesiculosus on liver fibrosis via the TGF-β1/Smad pathway-mediated inhibition of extracellular matrix and autophagy

Li J, Chen K, Li S, Feng J, Liu T, Wang F, Zhang R, Xu S, Zhou Y, Zhou S, Xia Y, Lu J, Zhou Y, Guo C

Drug Design, Development and Therapy 2016, 10:619-630

Published Date: 12 February 2016

Randomized clinical trial: pharmacokinetics and safety of multimatrix mesalamine for treatment of pediatric ulcerative colitis

Cuffari C, Pierce D, Korczowski B, Fyderek K, Van Heusen H, Hossack S, Wan H, Edwards AY, Martin P

Drug Design, Development and Therapy 2016, 10:593-607

Published Date: 4 February 2016

Establishment of a novel therapeutic vector targeting the trigeminal ganglion in rats

Xu K, Pan SY, Song JX, ,Liu XN, An N, Zheng X

Drug Design, Development and Therapy 2016, 10:585-592

Published Date: 4 February 2016

miR-125b acts as a tumor suppressor in chondrosarcoma cells by the sensitization to doxorubicin through direct targeting the ErbB2-regulated glucose metabolism

Tang XY, Zheng W, Ding M, Guo KJ, Yuan F, Feng H, Deng B, Sun W, Hou Y, Gao L

Drug Design, Development and Therapy 2016, 10:571-583

Published Date: 24 February 2016

Curcumin enhances the cytogenotoxic effect of etoposide in leukemia cells through induction of reactive oxygen species

Papież MA, Krzyściak W, Szade K, Bukowska-Straková K, Kozakowska M, Hajduk K, Bystrowska B, Dulak J, Jozkowicz A

Drug Design, Development and Therapy 2016, 10:557-570

Published Date: 4 February 2016

Targeting the D1-N-methyl-D-aspartate receptor complex reduces L-dopa-induced dyskinesia in 6-hydroxydopamine-lesioned Parkinson’s rats

Song L, Zhang ZZ, Hu RG, Cheng J, Li L, Fan QY, Wu N, Gan J, Zhou MZ, Liu ZG

Drug Design, Development and Therapy 2016, 10:547-555

Published Date: 3 February 2016

Antiviral therapy: a perspective

Shahidi Bonjar AH

Drug Design, Development and Therapy 2016, 10:541-546

Published Date: 2 February 2016

Preparation and characterization of silymarin synchronized-release microporous osmotic pump tablets

Zeng QP, Liu ZH, Huang AW, Zhang J, Song HT

Drug Design, Development and Therapy 2016, 10:519-531

Published Date: 29 January 2016

Determination of the binding mode for anti-inflammatory natural product xanthohumol with myeloid differentiation protein 2

Fu W, Chen L, Wang Z, Zhao C, Chen G, Liu X, Dai Y, Cai Y, Li C, Zhou J, Liang G

Drug Design, Development and Therapy 2016, 10:455-463

Published Date: 27 January 2016

Amelioration of concanavalin A-induced autoimmune hepatitis by magnesium isoglycyrrhizinate through inhibition of CD4+CD25-CD69+ subset proliferation

Yang Q, Wang J, Liu R, Wang Z, Li Y, Zhang Y, Hao X, Huang Y, Xie W, Wei H

Drug Design, Development and Therapy 2016, 10:443-453

Published Date: 25 January 2016

Efficacy of trabectedin in advanced soft tissue sarcoma: beyond lipo- and leiomyosarcoma [Corrigendum]

De Sanctis R, Marrari A, Marchetti S, Mussi C, Balzarini L, Lutman FR, Daolio P, Bastoni S, Bertuzzi AF, Quagliuolo V, Santoro A

Drug Design, Development and Therapy 2016, 10:441-442

Published Date: 28 January 2016

In vitro stress effect on degradation and drug release behaviors of basic fibroblast growth factor – poly(lactic-co-glycolic-acid) microsphere

Xiong Y, Yu ZP, Lang Y, Hu JY, Li H, Yan YG, Tu CQ, Yang TF, Song YM, Duan H, Pei FX

Drug Design, Development and Therapy 2016, 10:431-440

Published Date: 25 January 2016

Formulation, optimization, and pharmacodynamic evaluation of chitosan/phospholipid/β-cyclodextrin microspheres

Shan L, Tao EX, Meng QH, Hou WX, Liu K, Shang HC, Tang JB, Zhang WF

Drug Design, Development and Therapy 2016, 10:417-429

Published Date: 25 January 2016

Depot injectable atorvastatin biodegradable in situ gel: development, optimization, in vitro, and in vivo evaluation

Ahmed TA, Alharby YA, El-Helw AM, Hosny KM, El-Say KM

Drug Design, Development and Therapy 2016, 10:405-415

Published Date: 20 January 2016

High-dose OxyContin to treat pain associated with bone metastasis in patients with small-cell lung cancer: a case study report

Zhou T, Zhang X, Dong Y, Zhuang FF, Jiang FQ, Yu JM, Zhang B

Drug Design, Development and Therapy 2016, 10:383-387

Published Date: 19 January 2016

Effects of probenecid and cimetidine on the pharmacokinetics of nemonoxacin in healthy Chinese volunteers

Zhang YF, Dai XJ, Yang Y, Chen XY, Wang T, Tang YB, Tsai CY, Chang LW, Chang YT, Zhong DF

Drug Design, Development and Therapy 2016, 10:357-370

Published Date: 20 January 2016

Clinical pharmacology study of cariprazine (MP-214) in patients with schizophrenia (12-week treatment)

Nakamura T, Kubota T, Iwakaji A, Imada M, Kapás M, Morio Y

Drug Design, Development and Therapy 2016, 10:327-338

Published Date: 14 January 2016

Evidence of the gastroprotective and anti-Helicobacter pylori activities of β-mangostin isolated from Cratoxylum arborescens (vahl) blume

Sidahmed HMA, Hashim NM, Mohan S, Abdelwahab SI, Taha MME, Dehghan F, Yahayu M, Ee GCL, Loke MF, Vadivelu J

Drug Design, Development and Therapy 2016, 10:297-313

Published Date: 13 January 2016

Liposomal flucytosine capped with gold nanoparticle formulations for improved ocular delivery

Salem HF, Ahmed SM, Omar MM

Drug Design, Development and Therapy 2016, 10:277-295

Published Date: 13 January 2016

Quetiapine monotherapy in acute treatment of generalized anxiety disorder: a systematic review and meta-analysis of randomized controlled trials

Maneeton N, Maneeton B, Woottiluk P, Likhitsathian S, Suttajit S, Boonyanaruthee V, Srisurapanont M

Drug Design, Development and Therapy 2016, 10:259-276

Published Date: 12 January 2016

A clinical prognostic scoring system for resectable gastric cancer to predict survival and benefit from paclitaxel- or oxaliplatin-based adjuvant chemotherapy

Qian J, Qian Y, Wang J, Gu B, Pei D, He S, Zhu F, Røe OD, Xu J, Liu L, Gu Y, Guo R, Yin Y, Shu Y, Chen X

Drug Design, Development and Therapy 2016, 10:241-258

Published Date: 24 February 2016

Pasireotide: a novel treatment for patients with acromegaly

Cuevas-Ramos D, Fleseriu M

Drug Design, Development and Therapy 2016, 10:227-239

Published Date: 11 January 2016

Spotlight on ixazomib: potential in the treatment of multiple myeloma

Muz B, Ghazarian RN, Ou M, Luderer MJ, Kusdono HD, Azab AK

Drug Design, Development and Therapy 2016, 10:217-226

Published Date: 11 January 2016

Preparation, characterization, and in vivo evaluation of intranasally administered liposomal formulation of donepezil

Al Asmari AK, Ullah Z, Tariq M, Fatani A

Drug Design, Development and Therapy 2016, 10:205-215

Published Date: 12 January 2016

Design and evaluation of novel interferon lambda analogs with enhanced antiviral activity and improved drug attributes

Yu D, Zhao M, Dong L, Zhao L, Zou M, Sun H, Zhang M, Liu H, Zou Z

Drug Design, Development and Therapy 2016, 10:163-182

Published Date: 6 January 2016

Isolation and evaluation of biological efficacy of quercetol in human hepatic carcinoma cells

Ali H, Dixit S, Ali D, Alkahtane AA, Alarifi S, Ali BA, Alkahtani S

Drug Design, Development and Therapy 2016, 10:155-162

Published Date: 6 January 2016

Self-emulsifying drug delivery systems as a tool to improve solubility and bioavailability of resveratrol

Balata GF, Essa EA, Shamardl HA, Zaidan SH, Abourehab MAS

Drug Design, Development and Therapy 2016, 10:117-128

Published Date: 5 January 2016

The gastroprotective effects of hydroalcoholic extract of Monolluma quadrangula against ethanol-induced gastric mucosal injuries in Sprague Dawley rats

Ibrahim IAA, Abdulla MA, Hajrezaie M, Bader A, Shahzad N, Al-Ghamdi SS, Gushash AS, Hasanpourghadi M

Drug Design, Development and Therapy 2016, 10:93-105

Published Date: 30 December 2015

Promoting effect of small molecules in cardiomyogenic and neurogenic differentiation of rat bone marrow-derived mesenchymal stem cells

Khanabdali R, Saadat A, Fazilah M, Bazli KFK, Qazi RM, Khalid RS, Hasan Adli DS, Moghadamtousi SZ, Naeem N, Khan I, Salim A, Shamsuddin SAA, Mohan G

Drug Design, Development and Therapy 2016, 10:81-91

Published Date: 24 December 2015

MicroRNA-125a-5p modulates human cervical carcinoma proliferation and migration by targeting ABL2

Qin X, Wan Y, Wang S, Xue M

Drug Design, Development and Therapy 2016, 10:71-79

Published Date: 24 December 2015

BCc1, the novel antineoplastic nanocomplex, showed potent anticancer effects in vitro and in vivo

Kalanaky S, Hafizi M, Fakharzadeh S, Vasei M, Langroudi L, Janzamin E, Hashemi SM, Khayamzadeh M, Soleimani M, Akbari ME, Nazaran MH

Drug Design, Development and Therapy 2016, 10:59-70

Published Date: 30 December 2015

MEK inhibitors and their potential in the treatment of advanced melanoma: the advantages of combination therapy

Tran KA, Cheng MY, Mitra A, Ogawa H, Shi VY, Olney LP, Kloxin AM, Maverakis E

Drug Design, Development and Therapy 2016, 10:43-52

Published Date: 21 December 2015

Modulation of neurotrophic signaling pathways by polyphenols

Moosavi F, Hosseini R, Saso L, Firuzi O

Drug Design, Development and Therapy 2016, 10:23-42

Published Date: 21 December 2015

Plasmid pORF-hTRAIL targeting to glioma using transferrin-modified polyamidoamine dendrimer

Gao S, Li J, Jiang C, Hong B, Hao B

Drug Design, Development and Therapy 2016, 10:1-11

Published Date: 17 December 2015