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International Journal of Nanomedicine


Archive: Volume 16, 2021

Encapsulating Halofuginone Hydrobromide in TPGS Polymeric Micelles Enhances Efficacy Against Triple-Negative Breast Cancer Cells

Zuo R, Zhang J, Song X, Hu S, Gao X, Wang J, Ji H, Ji C, Peng L, Si H, Li G, Fang K, Zhang J, Jiang S, Guo D

International Journal of Nanomedicine 2021, 16:1587-1600

Published Date: 26 February 2021

Engineering Exosome-Like Nanovesicles Derived from Asparagus cochinchinensis Can Inhibit the Proliferation of Hepatocellular Carcinoma Cells with Better Safety Profile

Zhang L, He F, Gao L, Cong M, Sun J, Xu J, Wang Y, Hu Y, Asghar S, Hu L, Qiao H

International Journal of Nanomedicine 2021, 16:1575-1586

Published Date: 26 February 2021

Copper Nanoparticles Induce Oxidative Stress via the Heme Oxygenase 1 Signaling Pathway in vitro Studies

Zou L, Cheng G, Xu C, Liu H, Wang Y, Li N, Fan X, Zhu C, Xia W

International Journal of Nanomedicine 2021, 16:1565-1573

Published Date: 26 February 2021

Immunotherapy of Tumor RNA-Loaded Lipid Nanoparticles Against Hepatocellular Carcinoma

Zhang Y, Xie F, Yin Y, Zhang Q, Jin H, Wu Y, Pang L, Li J, Gao J

International Journal of Nanomedicine 2021, 16:1553-1564

Published Date: 25 February 2021

Advances in Multiple Stimuli-Responsive Drug-Delivery Systems for Cancer Therapy

Jia R, Teng L, Gao L, Su T, Fu L, Qiu Z, Bi Y

International Journal of Nanomedicine 2021, 16:1525-1551

Published Date: 25 February 2021

Atomic Layer Deposition of ZrO2 on Titanium Inhibits Bacterial Adhesion and Enhances Osteoblast Viability

Jo Y, Kim YT, Cho H, Ji MK, Heo J, Lim HP

International Journal of Nanomedicine 2021, 16:1509-1523

Published Date: 24 February 2021

Nanosized Drug Delivery Systems for Breast Cancer Stem Cell Targeting

Lv L, Shi Y, Wu J, Li G

International Journal of Nanomedicine 2021, 16:1487-1508

Published Date: 23 February 2021

Nucleus-Targeted Photosensitizer Nanoparticles for Photothermal and Photodynamic Therapy of Breast Carcinoma

Liu J, Yin Y, Yang L, Lu B, Yang Z, Wang W, Li R

International Journal of Nanomedicine 2021, 16:1473-1485

Published Date: 22 February 2021

Nanoemulgel, an Innovative Carrier for Diflunisal Topical Delivery with Profound Anti-Inflammatory Effect: in vitro and in vivo Evaluation

Bashir M, Ahmad J, Asif M, Khan SUD, Irfan M, Y Ibrahim A, Asghar S, Khan IU, Iqbal MS, Haseeb A, Khalid SH, AS Abourehab M

International Journal of Nanomedicine 2021, 16:1457-1472

Published Date: 22 February 2021

Interleukin-1β-Treated Mesenchymal Stem Cells Inhibit Inflammation in Hippocampal Astrocytes Through Exosome-Activated Nrf-2 Signaling

Liu K, Cai GL, Zhuang Z, Pei SY, Xu SN, Wang YN, Wang H, Wang X, Cui C, Sun MC, Guo SH, Jia KP, Wang XZ, Cai GF

International Journal of Nanomedicine 2021, 16:1423-1434

Published Date: 22 February 2021

Progress of Nanotechnology in Diabetic Retinopathy Treatment

Liu Y, Wu N

International Journal of Nanomedicine 2021, 16:1391-1403

Published Date: 24 February 2021

Low Dose Curcumin Administered in Hyaluronic Acid-Based Nanocapsules Induces Hypotensive Effect in Hypertensive Rats

Czyzynska-Cichon I, Janik-Hazuka M, Szafraniec-Szczęsny J, Jasinski K, Węglarz WP, Zapotoczny S, Chlopicki S

International Journal of Nanomedicine 2021, 16:1377-1390

Published Date: 24 February 2021

Integration of Dual Targeting and Dual Therapeutic Modules Endows Self-Assembled Nanoparticles with Anti-Tumor Growth and Metastasis Functions

Chen B, Dong X, Dong X, Wang Q, Wu M, Wu J, Lou X, Xia F, Wang W, Dai J, Wang S

International Journal of Nanomedicine 2021, 16:1361-1376

Published Date: 18 February 2021

Nanocarriers-Mediated Drug Delivery Systems for Anticancer Agents: An Overview and Perspectives

Edis Z, Wang J, Waqas MK, Ijaz M, Ijaz M

International Journal of Nanomedicine 2021, 16:1313-1330

Published Date: 17 February 2021

Advances in Subcutaneous Delivery Systems of Biomacromolecular Agents for Diabetes Treatment

Li C, Wan L, Luo J, Jiang M, Wang K

International Journal of Nanomedicine 2021, 16:1261-1280

Published Date: 17 February 2021

Development of a Solid Supersaturable Micelle of Revaprazan for Improved Dissolution and Oral Bioavailability Using Box-Behnken Design

Goo YT, Sa CK, Choi JY, Kim MS, Kim CH, Kim HK, Choi YW

International Journal of Nanomedicine 2021, 16:1245-1259

Published Date: 17 February 2021

Iron Oxide Nanoparticles Combined with Cytosine Arabinoside Show Anti-Leukemia Stem Cell Effects on Acute Myeloid Leukemia by Regulating Reactive Oxygen Species

Dou J, Li L, Guo M, Mei F, Zheng D, Xu H, Xue R, Bao X, Zhao F, Zhang Y

International Journal of Nanomedicine 2021, 16:1231-1244

Published Date: 17 February 2021

In vivo Pharmacokinetics and in vitro Release of Imatinib Mesylate-Loaded Liposomes for Pulmonary Delivery

Xu H, Ji H, Li Z, Qiao W, Wang C, Tang J

International Journal of Nanomedicine 2021, 16:1221-1229

Published Date: 16 February 2021

Physicochemical Characterization of Finasteride Nanosystem for Enhanced Topical Delivery

Irfan MM, Shah SU, Khan IU, Munir MU, Khan NR, Shah KU, Rehman SU, Sohaib M, Basit HM, Mahmood S

International Journal of Nanomedicine 2021, 16:1207-1220

Published Date: 16 February 2021

In vitro Study on Synergistic Interactions Between Free and Encapsulated Q-Griffithsin and Antiretrovirals Against HIV-1 Infection

Minooei F, Fried JR, Fuqua JL, Palmer KE, Steinbach-Rankins JM

International Journal of Nanomedicine 2021, 16:1189-1206

Published Date: 15 February 2021

Engineering of Neutrophil Membrane Camouflaging Nanoparticles Realizes Targeted Drug Delivery for Amplified Antitumor Therapy

Wang J, Gu X, Ouyang Y, Chu L, Xu M, Wang K, Tong X

International Journal of Nanomedicine 2021, 16:1175-1187

Published Date: 15 February 2021

Bursting the Virulence Traits of MDR Strain of Candida albicans Using Sodium Alginate-based Microspheres Containing Nystatin-loaded MgO/CuO Nanocomposites

Abid S, Uzair B, Niazi MBK, Fasim F, Bano SA, Jamil N, Batool R, Sajjad S

International Journal of Nanomedicine 2021, 16:1157-1174

Published Date: 15 February 2021

Nanozymes as Enzyme Inhibitors

Huang Y, Jiang J, Wang Y, Chen J, Xi J

International Journal of Nanomedicine 2021, 16:1143-1155

Published Date: 12 February 2021

Biomaterial-Based Nanocomposite for Osteogenic Repurposing of Doxycycline

El-Habashy S, Eltaher H, Gaballah A, Mehanna R, El-Kamel AH

International Journal of Nanomedicine 2021, 16:1103-1126

Published Date: 12 February 2021

Application of Radiosensitizers in Cancer Radiotherapy

Gong L, Zhang Y, Liu C, Zhang M, Han S

International Journal of Nanomedicine 2021, 16:1083-1102

Published Date: 12 February 2021

Influence of Anti-Glaucoma Drugs on Uptake of Extracellular Vesicles by Trabecular Meshwork Cells

Tabak S, Schreiber-Avissar S, Beit-Yannai E

International Journal of Nanomedicine 2021, 16:1067-1081

Published Date: 12 February 2021

A Novel Targeted Therapy System for Cervical Cancer:  Co-Delivery System  of  Antisense LncRNA of MDC1 and Oxaliplatin Magnetic Thermosensitive Cationic Liposome Drug Carrier

Ye H, Chu X, Cao Z, Hu X, Wang Z, Li M, Wan L, Li Y, Cao Y, Diao Z, Peng F, Liu J, Xu L

International Journal of Nanomedicine 2021, 16:1051-1066

Published Date: 11 February 2021

The Role and Activation Mechanism of TAZ in Hierarchical Microgroove/Nanopore Topography-Mediated Regulation of Stem Cell Differentiation

Hu P, Gao Q, Zheng H, Tian Y, Zheng G, Yao X, Zhang J, Wu X, Sui L

International Journal of Nanomedicine 2021, 16:1021-1036

Published Date: 11 February 2021

CD-340 Functionalized Doxorubicin-Loaded Nanoparticle Induces Apoptosis and Reduces Tumor Volume Along with Drug-Related Cardiotoxicity in Mice [Corrigendum]

Mondal L, Mukherjee B, Das K, Bhattacharya S, Dutta D, Chakraborty S, Pal MM, Gaonkar RH, Debnath MC

International Journal of Nanomedicine 2021, 16:1001-1003

Published Date: 11 February 2021

Modulating the Biomechanical Properties of Engineered Connective Tissues by Chitosan-Coated Multiwall Carbon Nanotubes

Kittana N, Assali M, Zimmermann WH, Liaw N, Santos GL, Rehman A, Lutz S

International Journal of Nanomedicine 2021, 16:989-1000

Published Date: 15 February 2021

Lipoparticles for Synergistic Chemo-Photodynamic Therapy to Ovarian Carcinoma Cells: In vitro and in vivo Assessments

Ali S, Amin MU, Tariq I, Sohail MF, Ali MY, Preis E, Ambreen G, Pinnapireddy SR, Jedelská J, Schäfer J, Bakowsky U

International Journal of Nanomedicine 2021, 16:951-976

Published Date: 11 February 2021

Rapid Detection Method for Pathogenic Candida Captured by Magnetic Nanoparticles and Identified Using SERS via AgNPs+

Hu S, Kang H, Gu F, Wang C, Cheng S, Gong W, Wang L, Gu B, Yang Y

International Journal of Nanomedicine 2021, 16:941-950

Published Date: 11 February 2021

Rhamnolipid-Based Liposomes as Promising Nano-Carriers for Enhancing the Antibacterial Activity of Peptides Derived from Bacterial Toxin-Antitoxin Systems

Sanches BCP, Rocha CA, Martin Bedoya JG, Silva VL, Silva PB, Fusco-Almeida AM, Chorilli M, Contiero J, Crusca E, Marchetto R

International Journal of Nanomedicine 2021, 16:925-939

Published Date: 10 February 2021

Improved Pharmacodynamic Potential of Rosuvastatin by Self-Nanoemulsifying Drug Delivery System: An in vitro and in vivo Evaluation

Verma R, Kaushik A, Almeer R, Rahman MH, Abdel-Daim MM, Kaushik D

International Journal of Nanomedicine 2021, 16:905-924

Published Date: 9 February 2021

Preparation of Ag Nanoclusters-Modified Non-Sintered Silica Ceramic-Like Nanosheet for Removing Dyes and Bacteria from Water

Ren X, Lv X, Chen Z, Zhang P, Hu Snr X, Mei X

International Journal of Nanomedicine 2021, 16:895-904

Published Date: 9 February 2021

Pterostilbene Nanoparticles Downregulate Hypoxia-Inducible Factors in Hepatoma Cells Under Hypoxic Conditions

Tzeng WS, Teng WL, Huang PH, Lin TC, Yen FL, Shiue YL

International Journal of Nanomedicine 2021, 16:867-879

Published Date: 5 February 2021

Combined Photothermal and Ionizing Radiation Sensitization of Triple-Negative Breast Cancer Using Triangular Silver Nanoparticles

Sears J, Swanner J, Fahrenholtz CD, Snyder C, Rohde M, Levi-Polyachenko N, Singh R

International Journal of Nanomedicine 2021, 16:851-865

Published Date: 5 February 2021

Nanostructured Cellulose–Gellan–Xyloglucan–Lysozyme Dressing Seeded with Mesenchymal Stem Cells for Deep Second-Degree Burn Treatment

Costa de Oliveira Souza CM, de Souza CF, Mogharbel BF, Irioda AC, Cavichiolo Franco CR, Sierakowski MR, Athayde Teixeira de Carvalho K

International Journal of Nanomedicine 2021, 16:833-850

Published Date: 5 February 2021

Recent Advances in Nanotechnology-Based Biosensors Development for Detection of Arsenic, Lead, Mercury, and Cadmium

Salek Maghsoudi A, Hassani S, Mirnia K, Abdollahi M

International Journal of Nanomedicine 2021, 16:803-832

Published Date: 4 February 2021

tLyP-1 Peptide Functionalized Human H Chain Ferritin for Targeted Delivery of Paclitaxel

Ma Y, Li R, Dong Y, You C, Huang S, Li X, Wang F, Zhang Y

International Journal of Nanomedicine 2021, 16:789-802

Published Date: 4 February 2021

A Selenium Nanocomposite Protects the Mouse Brain from Oxidative Injury Following Intracerebral Hemorrhage

Yang Y, Deng G, Wang P, Lv G, Mao R, Sun Y, Wang B, Liu X, Bian L, Zhou D

International Journal of Nanomedicine 2021, 16:775-788

Published Date: 4 February 2021

Nanotoxic Effects of Silver Nanoparticles on Normal HEK-293 Cells in Comparison to Cancerous HeLa Cell Line

Liu X, Shan K, Shao X, Shi X, He Y, Liu Z, Jacob JA, Deng L

International Journal of Nanomedicine 2021, 16:753-761

Published Date: 3 February 2021

Nanostructured Coating of Non-Crystalline Tantalum Pentoxide on Polyetheretherketone Enhances RBMS Cells/HGE Cells Adhesion

Pang Z, Pan Z, Ma M, Xu Z, Mei S, Jiang Z, Yin F

International Journal of Nanomedicine 2021, 16:725-740

Published Date: 29 January 2021

EDTA-K2 Improves the Detection Sensitivity of SARS-CoV-2 IgM and IgG Antibodies by Chelating Colloidal Gold in the Immunochromatographic Assay

Hu X, Wu C, Situ B, Tian P, An T, Li Q, Pan W, Zhang R, Yang B, Sun D, Hu Y, Wang Q, Zheng L

International Journal of Nanomedicine 2021, 16:715-724

Published Date: 29 January 2021

The Opportunities and Challenges of Silica Nanomaterial for Atherosclerosis

Sha X, Dai Y, Song X, Liu S, Zhang S, Li J

International Journal of Nanomedicine 2021, 16:701-714

Published Date: 28 January 2021

Characterization of Optimized TiO2 Nanotubes Morphology for Medical Implants: Biological Activity and Corrosion Resistance

Nogueira RP, Deuzimar Uchoa J, Hilario F, Santana-Melo GDF, de Vasconcellos LMR, Marciano FR, Roche V, Moreira Jorge Junior A, Lobo AO

International Journal of Nanomedicine 2021, 16:667-682

Published Date: 26 January 2021

Cytotoxicity Effects of Curcumin Loaded on Chitosan Alginate Nanospheres on the KMBC-10 Spheroids Cell Line

Afzali E, Eslaminejad T, Yazdi Rouholamini SE, Shahrokhi-Farjah M, Ansari M

International Journal of Nanomedicine 2021, 16:579-589

Published Date: 25 January 2021

Nanomedicine for the SARS-CoV-2: State-of-the-Art and Future Prospects

Varahachalam SP, Lahooti B, Chamaneh M, Bagchi S, Chhibber T, Morris K, Bolanos JF, Kim NY, Kaushik A

International Journal of Nanomedicine 2021, 16:539-560

Published Date: 22 January 2021

Advances in Hollow Inorganic Nanomedicines for Photothermal-Based Therapies

Ling C, Wang X, Shen Y

International Journal of Nanomedicine 2021, 16:493-513

Published Date: 22 January 2021

Eco-Friendly and Facile Synthesis of Antioxidant, Antibacterial and Anticancer Dihydromyricetin-Mediated Silver Nanoparticles

Li Z, Ali I, Qiu J, Zhao H, Ma W, Bai A, Wang D, Li J

International Journal of Nanomedicine 2021, 16:481-492

Published Date: 19 January 2021

Galactose Modified Liposomes for Effective Co-Delivery of Doxorubicin and Combretastatin A4

Lian B, Wei H, Pan R, Sun J, Zhang B, Wu J, Li X, Tian G

International Journal of Nanomedicine 2021, 16:457-467

Published Date: 15 January 2021

Decrease in Cellular Nanovesicles Concentration in Blood of Athletes More Than 15 Hours After Marathon

Jan Z, Drab M, Drobne D, Bedina Zavec A, Benčina M, Drasler B, Hočevar M, Krek JL, Pađen L, Pajnič M, Repar N, Šimunič B, Štukelj R, Kralj-Iglič V

International Journal of Nanomedicine 2021, 16:443-456

Published Date: 20 January 2021

Echogenic, Ultrasound-Sensitive Chitosan Nanodroplets for Spatiotemporally Controlled DKK-2 Gene Delivery to Prostate Cancer Cells

Liu X, Shi D, Guo L, Zhou X, Shang M, Sun X, Meng D, Zhao Y, Li J

International Journal of Nanomedicine 2021, 16:421-432

Published Date: 15 January 2021

The Adjuvant of α-Galactosylceramide Presented by Gold Nanoparticles Enhances Antitumor Immune Responses of MUC1 Antigen-Based Tumor Vaccines

Liu Y, Wang Z, Yu F, Li M, Zhu H, Wang K, Meng M, Zhao W

International Journal of Nanomedicine 2021, 16:403-420

Published Date: 14 January 2021

Aspects of Point-of-Care Diagnostics for Personalized Health Wellness

Kumar S, Nehra M, Khurana S, Dilbaghi N, Kumar V, Kaushik A, Kim KH

International Journal of Nanomedicine 2021, 16:383-402

Published Date: 14 January 2021

Inhibition of Circulating Exosomal miRNA-20b-5p Accelerates Diabetic Wound Repair

Chen K, Yu T, Wang X

International Journal of Nanomedicine 2021, 16:371-381

Published Date: 14 January 2021

Effect of Gold Nanoparticle Radiosensitization on Plasmid DNA Damage Induced by High-Dose-Rate Brachytherapy

Yogo K, Misawa M, Shimizu M, Shimizu H, Kitagawa T, Hirayama R, Ishiyama H, Furukawa T, Yasuda H

International Journal of Nanomedicine 2021, 16:359-370

Published Date: 14 January 2021

Oral Nanoparticles of SNX10-shRNA Plasmids Ameliorate Mouse Colitis

Bao WL, Wu Q, Hu B, Sun D, Zhao S, Shen X, Cheng H, Shen W

International Journal of Nanomedicine 2021, 16:345-357

Published Date: 13 January 2021

Selenium Nanoparticles by Moderating Oxidative Stress Promote Differentiation of Mesenchymal Stem Cells to Osteoblasts

Fatima S, Alfrayh R, Alrashed M, Alsobaie S, Ahmad R, Mahmood A

International Journal of Nanomedicine 2021, 16:331-343

Published Date: 13 January 2021

p53 Promoted Ferroptosis in Ovarian Cancer Cells Treated with Human Serum Incubated-Superparamagnetic Iron Oxides

Zhang Y, Xia M, Zhou ZZ, Hu X, Wang J, Zhang M, Li Y, Sun L, Chen F, Yu H

International Journal of Nanomedicine 2021, 16:283-296

Published Date: 12 January 2021

Delivery of Rapamycin by Liposomes Synergistically Enhances the Chemotherapy Effect of 5-Fluorouracil on Colorectal Cancer

Chen YQ, Zhu WT, Lin CY, Yuan ZW, Li ZH, Yan PK

International Journal of Nanomedicine 2021, 16:269-281

Published Date: 12 January 2021

Au-Pt Nanoparticle Formulation as a Radiosensitizer for Radiotherapy with Dual Effects

Yang S, Han G, Chen Q, Yu L, Wang P, Zhang Q, Dong J, Zhang W, Huang J

International Journal of Nanomedicine 2021, 16:239-248

Published Date: 12 January 2021

Enhanced Antitumor Efficacy of Macrophage-Mediated Egg Yolk Lipid-Derived Delivery System Against Breast Cancer [Corrigendum]

Lv Y, Jun Y, Tang Z, Li X, Tao M, Zhang Z, Liu L, Sun S, Wang Q, Luo C, Zhang L

International Journal of Nanomedicine 2021, 16:237-238

Published Date: 12 January 2021

Antimicrobial Double-Layer Wound Dressing Based on Chitosan/Polyvinyl Alcohol/Copper: In vitro and in vivo Assessment

Ghasemian Lemraski E, Jahangirian H, Dashti M, Khajehali E, Sharafinia S, Rafiee-Moghaddam R, Webster TJ

International Journal of Nanomedicine 2021, 16:223-235

Published Date: 11 January 2021

Magnetic Particle Imaging: In vitro Signal Analysis and Lumen Quantification of 21 Endovascular Stents

Wegner F, von Gladiss A, Haegele J, Grzyska U, Sieren MM, Stahlberg E, Oechtering TH, Lüdtke-Buzug K, Barkhausen J, Buzug TM, Friedrich T

International Journal of Nanomedicine 2021, 16:213-221

Published Date: 11 January 2021

Size and PEG Length-Controlled PEGylated Monocrystalline Superparamagnetic Iron Oxide Nanocomposite for MRI Contrast Agent

Deng LH, Jiang H, Lu FL, Wang HW, Pu Y, Wu CQ, Tang HJ, Xu Y, Chen TW, Zhu J, Shen CY, Zhang XM

International Journal of Nanomedicine 2021, 16:201-211

Published Date: 8 January 2021

Gene Therapy for Drug-Resistant Glioblastoma via Lipid-Polymer Hybrid Nanoparticles Combined with Focused Ultrasound

Yang Q, Zhou Y, Chen J, Huang N, Wang Z, Cheng Y

International Journal of Nanomedicine 2021, 16:185-199

Published Date: 8 January 2021

Engineered Nanomaterials: The Challenges and Opportunities for Nanomedicines

Albalawi F, Hussein MZ, Fakurazi S, Masarudin MJ

International Journal of Nanomedicine 2021, 16:161-184

Published Date: 8 January 2021

Effect of Hydrothermal Media on the in-situ Whisker Growth on Biphasic Calcium Phosphate Ceramics

Feng C, Wu Y, Cao Q, Li X, Zhu X, Zhang X

International Journal of Nanomedicine 2021, 16:147-159

Published Date: 8 January 2021

Genetically Engineered Bacterial Protein Nanoparticles for Targeted Cancer Therapy

Yang H, Jiang F, Ji X, Wang L, Wang Y, Zhang L, Tang Y, Wang D, Luo Y, Li N, Wang Q, Zou J

International Journal of Nanomedicine 2021, 16:105-117

Published Date: 8 January 2021

Gold Nanoparticles Promote the Bone Regeneration of Periodontal Ligament Stem Cell Sheets Through Activation of Autophagy

Zhang Y, Wang P, Wang Y, Li J, Qiao D, Chen R, Yang W, Yan F

International Journal of Nanomedicine 2021, 16:61-73

Published Date: 6 January 2021

Antitumor Effects of Self-Assembling Peptide-Emodin in situ Hydrogels in vitro and in vivo

Wei W, Tang J, Li H, Huang Y, Yin C, Li D, Tang F

International Journal of Nanomedicine 2021, 16:47-60

Published Date: 6 January 2021

Acidic Monetite Complex Paste with Bleaching Property for In-depth Occlusion of Dentinal Tubules

Li B, Liu C, Fang ZH, Cao Y, Zhou Z, Lu H

International Journal of Nanomedicine 2021, 16:31-45

Published Date: 6 January 2021

Passive Diffusion vs Active pH-Dependent Encapsulation of Tyrosine Kinase Inhibitors Vandetanib and Lenvatinib into Folate-Targeted Ferritin Delivery System

Skubalova Z, Rex S, Sukupova M, Zahalka M, Skladal P, Pribyl J, Michalkova H, Weerasekera A, Adam V, Heger Z

International Journal of Nanomedicine 2021, 16:1-14

Published Date: 6 January 2021