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Drug Design, Development and Therapy


Archive: Volume11, 2017

Optimized formulation of multivesicular liposomes loaded with oleanolic acid enhanced anticancer effect in vitro

Wang Y, Luo Y, Li C, Zhang X, Pi C, Yu L, Wang S, Zhong Z

Drug Design, Development and Therapy 2017, 11:955-968

Published Date: 27 March 2017

Synergistic effects of antimicrobial peptide DP7 combined with antibiotics against multidrug-resistant bacteria

Wu X, Li Z, Li X, Tian Y, Fan Y, Yu C, Zhou B, Liu Y, Xiang R, Yang L

Drug Design, Development and Therapy 2017, 11:939-946

Published Date: 22 March 2017

Nanostructured lipid carriers for incorporation of copper(II) complexes to be used against Mycobacterium tuberculosis

Sato MR, Oshiro Junior JA, Machado RTA, de Souza PC, Campos DL, Pavan FR, da Silva PB, Chorilli M

Drug Design, Development and Therapy 2017, 11:909-921

Published Date: 20 March 2017

Clinical potential of SLAMF7 antibodies – focus on elotuzumab in multiple myeloma

Friend R, Bhutani M, Voorhees PM, Usmani SZ

Drug Design, Development and Therapy 2017, 11:893-900

Published Date: 20 March 2017

Delafloxacin: design, development and potential place in therapy

Candel FJ, Peñuelas M

Drug Design, Development and Therapy 2017, 11:881-891

Published Date: 20 March 2017

Artonin E induces p53-independent G1 cell cycle arrest and apoptosis through ROS-mediated mitochondrial pathway and livin suppression in MCF-7 cells

Etti IC, Rasedee A, Hashim NM, Abdul AB, Kadir A, Yeap SK, Waziri P, Malami I, Lim KL, Etti CJ

Drug Design, Development and Therapy 2017, 11:865-879

Published Date: 20 March 2017

Efficacy of cytokine-induced killer cell infusion as an adjuvant immunotherapy for hepatocellular carcinoma: a systematic review and meta-analysis

Yu R, Yang B, Chi X, Cai L, Liu C, Yang L, Wang X, He P, Lu X

Drug Design, Development and Therapy 2017, 11:851-864

Published Date: 17 March 2017

Cardioprotection with halogenated gases: how does it occur?

Guerrero-Orriach JL, Escalona Belmonte JJ, Ramirez Fernandez A, Ramirez Aliaga M, Rubio Navarro M, Cruz Mañas J

Drug Design, Development and Therapy 2017, 11:837-849

Published Date: 16 March 2017

Design, synthesis, and antimelanogenic effects of (2-substituted phenyl-1,3-dithiolan-4-yl)methanol derivatives

Kim DH, Kim SJ, Ullah S, Yun HY, Chun P, Moon HR

Drug Design, Development and Therapy 2017, 11:827-836

Published Date: 16 March 2017

Development of erythropoietin receptor-targeted drug delivery system against breast cancer using tamoxifen-loaded nanostructured lipid carriers

Beh CY, How CW, Foo JB, Foong JN, Selvarajah GT, Rasedee A

Drug Design, Development and Therapy 2017, 11:771-782

Published Date: 14 March 2017

Glycophenotype of breast and prostate cancer stem cells treated with thieno[2,3-b]pyridine anticancer compound

Mastelić A, Čikeš Čulić V, Režić Mužinić N, Vuica-Ross M, Barker D, Leung EY, Reynisson J, Markotić A

Drug Design, Development and Therapy 2017, 11:759-769

Published Date: 14 March 2017

An open-label, two-period comparative study on pharmacokinetics and safety of a combined ethinylestradiol/gestodene transdermal contraceptive patch

Zhang C, Li H, Xiong X, Zhai S, Wei Y, Zhang S, Zhang Y, Xu L, Liu L

Drug Design, Development and Therapy 2017, 11:725-731

Published Date: 10 March 2017

Pharmacokinetics and tolerability of DA-8031, a novel selective serotonin reuptake inhibitor for premature ejaculation in healthy male subjects

Shin D, Lee S, Yi S, Yoon SH, Cho JY, Bahng MY, Jang IJ, Yu KS

Drug Design, Development and Therapy 2017, 11:713-723

Published Date: 10 March 2017

Effects of dexamethasone coadministered with oseltamivir on the pharmacokinetics of oseltamivir in healthy volunteers

Jang K, Kim M, Oh J, Lee S, Cho JY, Yu KS, Choi TK, Lee SH, Lim KS

Drug Design, Development and Therapy 2017, 11:705-711

Published Date: 9 March 2017

Transcriptome analysis of endometrial tissues following GnRH agonist treatment in a mouse adenomyosis model

Guo S, Lu X, Gu R, Zhang D, Sun Y, Feng Y

Drug Design, Development and Therapy 2017, 11:695-704

Published Date: 9 March 2017

Development of venetoclax for therapy of lymphoid malignancies

Zhu H, Almasan A

Drug Design, Development and Therapy 2017, 11:685-694

Published Date: 9 March 2017

Does remifentanil attenuate renal ischemia–reperfusion injury better than dexmedetomidine in rat kidney?

Erkılıç E, Kesimci E, Alaybeyoğlu F, Kılınç I, Tural R, Yazgan A, Gümüş T, Sepici Dinçel A, Dumlu EG, Kanbak O

Drug Design, Development and Therapy 2017, 11:677-683

Published Date: 8 March 2017

Protective influence of hyaluronic acid on focal adhesion kinase activity in human skin fibroblasts exposed to ethanol

Donejko M, Rysiak E, Galicka E, Terlikowski R, Głażewska EK, Przylipiak A

Drug Design, Development and Therapy 2017, 11:669-676

Published Date: 6 March 2017

Paclitaxel-loaded star-shaped copolymer nanoparticles for enhanced malignant melanoma chemotherapy against multidrug resistance

Su Y, Hu J, Huang Z, Huang Y, Peng B, Xie N, Liu H

Drug Design, Development and Therapy 2017, 11:659-668

Published Date: 6 March 2017

New developments in the management of partial-onset epilepsy: role of brivaracetam

Coppola G, Iapadre G, Operto FF, Verrotti A

Drug Design, Development and Therapy 2017, 11:643-657

Published Date: 6 March 2017

MC-PPEA as a new and more potent inhibitor of CLP-induced sepsis and pulmonary inflammation than FK866

Huang P, Lee Jr MW, Sadrerafi K, Heruth DP, Zhang LQ, Maulik D, Ye SQ

Drug Design, Development and Therapy 2017, 11:629-641

Published Date: 3 March 2017

Metal complexes in cancer therapy – an update from drug design perspective

Ndagi U, Mhlongo N, Soliman ME

Drug Design, Development and Therapy 2017, 11:599-616

Published Date: 3 March 2017

Awake craniotomy anesthetic management using dexmedetomidine, propofol, and remifentanil

Prontera A, Baroni S, Marudi A, Valzania F, Feletti A, Benuzzi F, Bertellini E, Pavesi G

Drug Design, Development and Therapy 2017, 11:593-598

Published Date: 3 March 2017

Human papillomavirus (HPV): systemic treatment with Gene-Eden-VIR/Novirin safely and effectively clears virus

Polansky H, Itzkovitz E, Javaherian A

Drug Design, Development and Therapy 2017, 11:575-583

Published Date: 3 March 2017

In silico discovery and in vitro activity of inhibitors against Mycobacterium tuberculosis 7,8-diaminopelargonic acid synthase (Mtb BioA)

Billones JB, Carrillo MCO, Organo VG, Sy JBA, Clavio NAB, Macalino SJY, Emnacen IA, Lee AP, Ko PKL, Concepcion GP

Drug Design, Development and Therapy 2017, 11:563-574

Published Date: 2 March 2017

Adenosine A2A  receptor agonist prevents cardiac remodeling and dysfunction in spontaneously hypertensive male rats after myocardial infarction

da Silva JS, Gabriel-Costa D, Sudo RT, Wang H, Groban L, Ferraz EB, Nascimento JHM, Fraga CAM, Barreiro EJ, Zapata-Sudo G

Drug Design, Development and Therapy 2017, 11:553-562

Published Date: 6 March 2017

Defective DNA repair mechanisms in prostate cancer: impact of olaparib

De Felice F, Tombolini V, Marampon F, Musella A, Marchetti C

Drug Design, Development and Therapy 2017, 11:547-552

Published Date: 1 March 2017

Eteplirsen in the treatment of Duchenne muscular dystrophy

Lim KRQ, Maruyama R, Yokota T

Drug Design, Development and Therapy 2017, 11:533-545

Published Date: 28 February 2017

Sofosbuvir/velpatasvir regimen promises an effective pan-genotypic hepatitis C virus cure

Mir F, Kahveci AS, Ibdah JA, Tahan V

Drug Design, Development and Therapy 2017, 11:497-502

Published Date: 23 February 2017

Polyphosphoester nanoparticles as biodegradable platform for delivery of multiple drugs and siRNA

Elzeny H, Zhang F, Ali EN, Fathi HA, Zhang S, Li R, El-Mokhtar MA, Hamad MA, Wooley KL, Elsabahy M

Drug Design, Development and Therapy 2017, 11:483-496

Published Date: 22 February 2017

Antiproliferation effect of imatinib mesylate on MCF7, T-47D tumorigenic and MCF 10A nontumorigenic breast cell lines via PDGFR-β, PDGF-BB, c-Kit and SCF genes

Kadivar A, Kamalidehghan B, Akbari Javar H, Karimi B, Sedghi R, Noordin MI

Drug Design, Development and Therapy 2017, 11:469-481

Published Date: 21 February 2017

Insight into resistance mechanisms of AZD4547 and E3810 to FGFR1 gatekeeper mutation via theoretical study

Liang D, Chen Q, Guo Y, Zhang T, Guo W

Drug Design, Development and Therapy 2017, 11:451-461

Published Date: 17 February 2017

Reversal of multidrug resistance in human lung cancer cells by delivery of 3-octadecylcarbamoylacrylic acid–cisplatin-based liposomes

Song J, Ren W, Xu T, Zhang Y, Guo H, Zhu S, Yang L

Drug Design, Development and Therapy 2017, 11:441-449

Published Date: 17 February 2017

Curcumin induces apoptosis and protective autophagy in castration-resistant prostate cancer cells through iron chelation

Yang C, Ma X, Wang Z, Zeng X, Hu Z, Ye Z, Shen G

Drug Design, Development and Therapy 2017, 11:431-439

Published Date: 14 February 2017

Novel 5-oxo-hexahydroquinoline derivatives: design, synthesis, in vitro P-glycoprotein-mediated multidrug resistance reversal profile and molecular dynamics simulation study

Shahraki O, Edraki N, Khoshneviszadeh M, Zargari F, Ranjbar S, Saso L, Firuzi O, Miri R

Drug Design, Development and Therapy 2017, 11:407-418

Published Date: 14 February 2017

Oral and transdermal drug delivery systems: role of lipid-based lyotropic liquid crystals

Rajabalaya R, Musa MN, Kifli N, David SR

Drug Design, Development and Therapy 2017, 11:393-406

Published Date: 13 February 2017

Antioxidant compounds and activities of the stem, flower, and leaf extracts of the anti-smoking Thai medicinal plant: Vernonia cinerea Less

Ketsuwan N, Leelarungrayub J, Kothan S, Singhatong S

Drug Design, Development and Therapy 2017, 11:383-391

Published Date: 13 February 2017

Pharmacokinetics of conivaptan use in patients with severe hepatic impairment

Marbury T, Fox J, Kaelin B, Pavliv L

Drug Design, Development and Therapy 2017, 11:373-382

Published Date: 13 February 2017

Gancidin W, a potential low-toxicity antimalarial agent isolated from an endophytic Streptomyces SUK10

Zin NM, Baba MS, Zainal-Abidin AH, Latip J, Mazlan NW, Edrada-Ebel R

Drug Design, Development and Therapy 2017, 11:351-363

Published Date: 8 February 2017

Kelussia odoratissima Mozaff. activates intrinsic pathway of apoptosis in breast cancer cells associated with S phase cell cycle arrest via involvement of p21/p27 in vitro and in vivo

Karimian H, Arya A, Fadaeinasab M, Razavi M, Hajrezaei M, Karim Khan A, Mohd Ali H, Abdulla MA, Noordin MI

Drug Design, Development and Therapy 2017, 11:337-350

Published Date: 1 February 2017

Drug delivery in overcoming the blood–brain barrier: role of nasal mucosal grafting

Marianecci C, Rinaldi F, Hanieh PN, Di Marzio L, Paolino D, Carafa M

Drug Design, Development and Therapy 2017, 11:325-335

Published Date: 27 January 2017

Phloretin exerts hypoglycemic effect in streptozotocin-induced diabetic rats and improves insulin resistance in vitro

Shen X, Zhou N, Mi L, Hu Z, Wang L, Liu X, Zhang S

Drug Design, Development and Therapy 2017, 11:313-324

Published Date: 7 February 2017

Obinutuzumab in chronic lymphocytic leukemia: design, development and place in therapy

Al-Sawaf O, Fischer K, Engelke A, Pflug N, Hallek M, Goede V

Drug Design, Development and Therapy 2017, 11:295-304

Published Date: 25 January 2017

Drugs in development for toxoplasmosis: advances, challenges, and current status

Alday PH, Doggett JS

Drug Design, Development and Therapy 2017, 11:273-293

Published Date: 25 January 2017

Theophylline action on primary human bronchial epithelial cells under proinflammatory stimuli and steroidal drugs: a therapeutic rationale approach

Gallelli L, Falcone D, Cannataro R, Perri M, Serra R, Pelaia G, Maselli R, Savino R, Spaziano G, D’Agostino B

Drug Design, Development and Therapy 2017, 11:265-272

Published Date: 23 January 2017

Plitidepsin: design, development, and potential place in therapy

Alonso-Álvarez S, Pardal E, Sánchez-Nieto D, Navarro M, Caballero MD, Mateos MV, Martín A

Drug Design, Development and Therapy 2017, 11:253-264

Published Date: 19 January 2017

Effect of roll compaction on granule size distribution of microcrystalline cellulose–mannitol mixtures: computational intelligence modeling and parametric analysis

Kazemi P, Khalid MH, Pérez Gago A, Kleinebudde P, Jachowicz R, Szlęk J, Mendyk A

Drug Design, Development and Therapy 2017, 11:241-251

Published Date: 18 January 2017

N-(3-hydroxymethyl-β-carboline-1-yl-ethyl-2-yl)-L-Phe: development toward a nanoscaled antitumor drug capable of treating complicated thrombosis and inflammation

Wu JH, Zhao M, Wang YJ, Wang YN, Zhu HM, Zhao SR, Gui L, Zhang XY, Peng SQ

Drug Design, Development and Therapy 2017, 11:225-239

Published Date: 17 January 2017

Spotlight on mavrilimumab for the treatment of rheumatoid arthritis: evidence to date

Crotti C, Raimondo MG, Becciolini A, Biggioggero M, Favalli EG

Drug Design, Development and Therapy 2017, 11:211-223

Published Date: 13 January 2017

Comparison of the long-term efficacy and safety of generic Tacrobell with original tacrolimus (Prograf) in kidney transplant recipients

Son SY, Jang HR, Lee JE, Yoo H, Kim K, Park JB, Kim SJ, Oh HY, Huh W

Drug Design, Development and Therapy 2017, 11:203-210

Published Date: 12 January 2017

Computational intelligence models to predict porosity of tablets using minimum features

Khalid MH, Kazemi P, Perez-Gandarillas L, Michrafy A, Szlęk J, Jachowicz R, Mendyk A

Drug Design, Development and Therapy 2017, 11:193-202

Published Date: 12 January 2017

Evaluation of a 2-aminoimidazole variant as adjuvant treatment for dermal bacterial infections

Draughn GL, Allen CL, Routh PA, Stone MR, Kirker KR, Boegli L, Schuchman RM, Linder KE, Baynes RE, James G, Melander C, Pollard A, Cavanagh J

Drug Design, Development and Therapy 2017, 11:153-162

Published Date: 11 January 2017

Pharmacokinetic and pharmacodynamic evaluation according to absorption differences in three formulations of ibuprofen

Shin D, Lee SJ, Ha Y, Choi YS, Kim JW, Park SR, Park MK

Drug Design, Development and Therapy 2017, 11:135-141

Published Date: 4 January 2017

A triazole derivative elicits autophagic clearance of polyglutamine aggregation in neuronal cells [Corrigendum]

Hsieh CH, Lee LC, Leong WY, Yang TC, Yao CF, Fang K

Drug Design, Development and Therapy 2017, 11:133-134

Published Date: 28 December 2016

Effects of multiple-dose ponesimod, a selective S1P1 receptor modulator, on lymphocyte subsets in healthy humans

Jurcevic S, Juif PE, Hamid C, Greenlaw R, D'Ambrosio D, Dingemanse J

Drug Design, Development and Therapy 2017, 11:123-131

Published Date: 28 December 2016

Anticancer and anti-inflammatory activities of girinimbine isolated from Murraya koenigii

Iman V, Mohan S, Abdelwahab SI, Karimian H, Nordin N, Fadaeinasab M, Noordin MI, Noor SM

Drug Design, Development and Therapy 2017, 11:103-121

Published Date: 28 December 2016

Vitamin D deficiency and the risk of tuberculosis: a meta-analysis

Huang SJ, Wang XH, Liu ZD, Cao WL, Han Y, Ma AG, Xu SF

Drug Design, Development and Therapy 2017, 11:91-102

Published Date: 28 December 2016

Analysis of pramipexole dose–response relationships in Parkinson's disease

Wang Y, Sun SG, Zhu SQ, Liu CF, Liu YM, Di Q, Shang HF, Ren Y, Xiang W, Chen SD

Drug Design, Development and Therapy 2017, 11:83-89

Published Date: 23 December 2016

Development of a chitosan based double layer-coated tablet as a platform for colon-specific drug delivery

Kim MS, Yeom DW, Kim SR, Yoon HY, Kim CH, Son HY, Kim JH, Lee S, Choi YW

Drug Design, Development and Therapy 2017, 11:45-57

Published Date: 21 December 2016

Spotlight on the 9-valent HPV vaccine

Lopalco PL

Drug Design, Development and Therapy 2017, 11:35-44

Published Date: 20 December 2016

Gastroretentive behavior of orally administered radiolabeled tamarind seed formulations in rabbits validated by gamma scintigraphy

Razavi M, Karimian H, Yeong CH, Fadaeinasab M, Khaing SL, Chung LY, Mohamad Haron DE, Noordin MI

Drug Design, Development and Therapy 2017, 11:1-15

Published Date: 19 December 2016