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Back to Journals » Drug Design, Development and Therapy » Volume 14
Drug Design, Development and Therapy
ISSN: 1177-8881
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Archive: Volume 14, 2020
Tanshinone IIA Ameliorates Streptozotocin-Induced Diabetic Nephropathy, Partly by Attenuating PERK Pathway-Induced Fibrosis
Xu S, He L, Ding K, Zhang L, Xu X, Wang S, Qian X
Drug Design, Development and Therapy 2020, 14:5773-5782
Published Date: 31 December 2020
Volumetric Absorptive Microsampling as a Sampling Alternative in Clinical Trials and Therapeutic Drug Monitoring During the COVID-19 Pandemic: A Review
Harahap Y, Diptasaadya R, Purwanto DJ
Drug Design, Development and Therapy 2020, 14:5757-5771
Published Date: 31 December 2020
RGD-Conjugated Resveratrol HSA Nanoparticles as a Novel Delivery System in Ovarian Cancer Therapy
Long Q, Zhu W, Guo L, Pu L
Drug Design, Development and Therapy 2020, 14:5747-5756
Published Date: 30 December 2020
Low-Dose Triple Antihypertensive Combination Therapy in Patients with Hypertension: A Randomized, Double-Blind, Phase II Study
Hong SJ, Sung KC, Lim SW, Kim SY, Kim W, Shin J, Park S, Kim HY, Rhee MY
Drug Design, Development and Therapy 2020, 14:5735-5746
Published Date: 31 December 2020
Pretreatment with Lactobacillus fermentum XY18 Relieves Gastric Injury Induced by HCl/Ethanol in Mice via Antioxidant and Anti-Inflammatory Mechanisms
Wang R, Zhou K, Xiong R, Yang Y, Yi R, Hu J, Liao W, Zhao X
Drug Design, Development and Therapy 2020, 14:5721-5734
Published Date: 30 December 2020
Effective Tacrolimus Treatment for Patients with Non-Severe Aplastic Anemia That is Refractory/Intolerant to Cyclosporine A: A Retrospective Study
Du Y, Huang Y, Zhou W, Liu X, Chen F, Yang C, Chen M, Ruan J, Han B
Drug Design, Development and Therapy 2020, 14:5711-5719
Published Date: 30 December 2020
Silencing of circHIPK3 Inhibits Pressure Overload-Induced Cardiac Hypertrophy and Dysfunction by Sponging miR-185-3p
Xu X, Wang J, Wang X
Drug Design, Development and Therapy 2020, 14:5699-5710
Published Date: 29 December 2020
Simultaneous Quantitative Analysis of Six Proton-Pump Inhibitors with a Single Marker and Evaluation of Stability of Investigated Drugs in Polypropylene Syringes for Continuous Infusion Use
Chen F, He X, Fang B, Wang S
Drug Design, Development and Therapy 2020, 14:5689-5698
Published Date: 24 December 2020
Intravenous Iron Isomaltoside 1000 Reduces Postoperative Anemia in Patients Undergoing Elective Urologic Surgery and Those with Urosepsis
Goh HJ, Lee KS, Kim TH, Kim KN, Lim HJ, Kim KS, Yang WJ, Jo JK
Drug Design, Development and Therapy 2020, 14:5679-5687
Published Date: 23 December 2020
Curcumin- and Cyclopamine-Loaded Liposomes to Enhance Therapeutic Efficacy Against Hepatic Fibrosis
Zhang T, Li Y, Song Y, Chen X, Li J, Peng Q, He J, Fei X
Drug Design, Development and Therapy 2020, 14:5667-5678
Published Date: 23 December 2020
Long-Term Efficacy and Safety of Subconjunctival/Perilesional 5-Fluorouracil Injections for Ocular Surface Squamous Neoplasia
Sun Y, Hua R
Drug Design, Development and Therapy 2020, 14:5659-5665
Published Date: 22 December 2020
Preventive Effect of Lactobacillus acidophilus XY27 on DSS-Induced Ulcerative Colitis in Mice
Hu T, Wang H, Xiang C, Mu J, Zhao X
Drug Design, Development and Therapy 2020, 14:5645-5657
Published Date: 22 December 2020
Magnesium Isoglycyrrhizinate Induces an Inhibitory Effect on Progression and Epithelial–Mesenchymal Transition of Laryngeal Cancer via the NF-κB/Twist Signaling
Zhang J, Zhao R, Xing D, Cao J, Guo Y, Li L, Sun Y, Tian L, Liu M
Drug Design, Development and Therapy 2020, 14:5633-5644
Published Date: 22 December 2020
Paeoniflorin Alleviates Abnormalities in Rats with Functional Dyspepsia by Stimulating the Release of Acetylcholine
Zou X, Wang Y, Wang Y, Yang J, Guo H, Cai Z
Drug Design, Development and Therapy 2020, 14:5623-5632
Published Date: 22 December 2020
Sinapultide-Loaded Microbubbles Combined with Ultrasound to Attenuate Lipopolysaccharide-Induced Acute Lung Injury in Mice
Liu D, Chen Y, Li F, Chen C, Wei P, Xiao D, Han B
Drug Design, Development and Therapy 2020, 14:5611-5622
Published Date: 22 December 2020
Clopidogrel-Induced Gastric Injury in Rats is Attenuated by Stable Gastric Pentadecapeptide BPC 157
Wu H, Wei M, Li N, Lu Q, Shrestha SM, Tan J, Zhang Z, Wu G, Shi R
Drug Design, Development and Therapy 2020, 14:5599-5610
Published Date: 21 December 2020
Agomelatine Attenuates Isoflurane-Induced Inflammation and Damage in Brain Endothelial Cells
Cheng F, Chang H, Yan F, Yang A, Liu J, Liu Y
Drug Design, Development and Therapy 2020, 14:5589-5598
Published Date: 18 December 2020
Beneficial Effects of Echinacoside on Diabetic Cardiomyopathy in Diabetic Db/Db Mice
Zhang X, Hao Y
Drug Design, Development and Therapy 2020, 14:5575-5587
Published Date: 18 December 2020
Brexpiprazole for the Treatment of Schizophrenia in Adults: An Overview of Its Clinical Efficacy and Safety and a Psychiatrist’s Perspective
Watanabe Y, Yamada S, Otsubo T, Kikuchi T
Drug Design, Development and Therapy 2020, 14:5559-5574
Published Date: 18 December 2020
4-Octyl Itaconate Alleviates Lipopolysaccharide-Induced Acute Lung Injury in Mice by Inhibiting Oxidative Stress and Inflammation
Li Y, Chen X, Zhang H, Xiao J, Yang C, Chen W, Wei Z, Chen X, Liu J
Drug Design, Development and Therapy 2020, 14:5547-5558
Published Date: 17 December 2020
The Drug Efficacy and Adverse Reactions in a Mouse Model of Oral Squamous Cell Carcinoma Treated with Oxaliplatin at Different Time Points During a Day [Corrigendum]
Yang K, Zhao N, Zhao D, Chen D, Li Y
Drug Design, Development and Therapy 2020, 14:5545-5546
Published Date: 16 December 2020
Super Activated Platelet Lysate, a Novel Autologous Platelet Lysate, Regulates the Expression of Inflammasome and Cytokine in the Experimental Periodontitis in Rats
Zhang Y, Zhuang D, Zhang Y, Lu H, Zhang H, Li T, Bi L
Drug Design, Development and Therapy 2020, 14:5535-5543
Published Date: 15 December 2020
Punicalagin Inhibits Tert-Butyl Hydroperoxide-Induced Apoptosis and Extracellular Matrix Degradation in Chondrocytes by Activating Autophagy and Ameliorates Murine Osteoarthritis
Kong J, Wang J, Gong X, Zheng X, Chen T
Drug Design, Development and Therapy 2020, 14:5521-5533
Published Date: 15 December 2020
The Effect of Switching from Tenofovir Disoproxil Fumarate (TDF) to Tenofovir Alafenamide (TAF) on Liver Enzymes, Glucose, and Lipid Profile
Squillace N, Ricci E, Menzaghi B, De Socio GV, Passerini S, Martinelli C, Mameli MS, Maggi P, Falasca K, Cordier L, Celesia BM, Salomoni E, Di Biagio A, Pellicanò GF, Bonfanti P
Drug Design, Development and Therapy 2020, 14:5515-5520
Published Date: 15 December 2020
Ulinastatin Inhibits the Proliferation, Invasion and Phenotypic Switching of PDGF-BB-Induced VSMCs via Akt/eNOS/NO/cGMP Signaling Pathway
Huang C, Huang W, Wang R, He Y
Drug Design, Development and Therapy 2020, 14:5505-5514
Published Date: 14 December 2020
A Review of Biomimetic Nanoparticle Drug Delivery Systems Based on Cell Membranes
Zhang M, Du Y, Wang S, Chen B
Drug Design, Development and Therapy 2020, 14:5495-5503
Published Date: 14 December 2020
Chronic Rhinosinusitis with Nasal Polyps: Targeting IgE with Anti-IgE Omalizumab Therapy
Kariyawasam HH, James LK
Drug Design, Development and Therapy 2020, 14:5483-5494
Published Date: 10 December 2020
Naringenin Prevents Propofol Induced Neurodegeneration in Neonatal Mice Brain and Long-Term Neurocognitive Impacts on Adults
Zou L, Ning M, Wang W, Zheng Y, Ma L, Lv J
Drug Design, Development and Therapy 2020, 14:5469-5482
Published Date: 10 December 2020
Live-Birth Outcomes and Congenital Malformations After Progestin-Primed Ovarian Stimulation in Maternal Endometriosis
Liang Z, Wang Y, Kuang Y
Drug Design, Development and Therapy 2020, 14:5459-5467
Published Date: 10 December 2020
The Median Effective Dose of Oxytocin Needed to Prevent Uterine Atony During Cesarean Delivery in Elderly Parturients
Wei CN, Deng JL, Dong JH, Ping ZP, Chen XZ
Drug Design, Development and Therapy 2020, 14:5451-5458
Published Date: 8 December 2020
Budesonide/Formoterol Anti-Inflammatory Reliever and Maintenance or Fluticasone Propionate/Salmeterol Plus As-Needed, Short-Acting β2 Agonist: Real-World Effectiveness in pAtients without Optimally Controlled asThma (REACT) Study
Cheng SL, Ho ML, Lai YF, Wang HC, Hsu JY, Liu SF, Huang MS, Lee CH, Lin CH, Hang LW, Liu YC, Yang KY, Wang JH
Drug Design, Development and Therapy 2020, 14:5441-5450
Published Date: 8 December 2020
Xanthohumol Inhibits TGF-β1-Induced Cardiac Fibroblasts Activation via Mediating PTEN/Akt/mTOR Signaling Pathway
Jiang C, Xie N, Sun T, Ma W, Zhang B, Li W
Drug Design, Development and Therapy 2020, 14:5431-5439
Published Date: 7 December 2020
Neohesperidin Ameliorates Steroid-Induced Osteonecrosis of the Femoral Head by Inhibiting the Histone Modification of lncRNA HOTAIR
Yuan S, Zhang C, Zhu Y, Wang B
Drug Design, Development and Therapy 2020, 14:5419-5430
Published Date: 7 December 2020
Mini-Tablets versus Nanoparticles for Controlling the Release of Amoxicillin: In vitro/In vivo Study
Gaber DA, Alhawas HS, Alfadhel FA, Abdoun SA, Alsubaiyel AM, Alsawi RM
Drug Design, Development and Therapy 2020, 14:5405-5418
Published Date: 7 December 2020
Design and Development of a Behaviorally Active Recombinant Neurotrophic Factor
Pekas NJ, Petersen JL, Sathyanesan M, Newton SS
Drug Design, Development and Therapy 2020, 14:5393-5403
Published Date: 4 December 2020
Ruthenium Complexes as Anticancer Agents: A Brief History and Perspectives
Lee SY, Kim CY, Nam TG
Drug Design, Development and Therapy 2020, 14:5375-5392
Published Date: 3 December 2020
Safety and Efficacy of Alpha Lipoic Acid During 4 Years of Observation: A Retrospective, Clinical Trial in Healthy Subjects in Primary Prevention
Derosa G, D'Angelo A, Preti P, Maffioli P
Drug Design, Development and Therapy 2020, 14:5367-5374
Published Date: 3 December 2020
The Skeletal Effects of Short-Term Triple Therapy in a Rat Model of Gastric Ulcer Induced by Helicobacter pylori Infection
Ekeuku SO, Thong BKS, Quraisiah A, Annuar F, Hanafiah A, Nur Azlina MF, Chin KY
Drug Design, Development and Therapy 2020, 14:5359-5366
Published Date: 3 December 2020
The Inhibitory Effects of Juglanin on Adipogenesis in 3T3-L1 Adipocytes
Wang G, Wu B, Xu W, Jin X, Wang K, Wang H
Drug Design, Development and Therapy 2020, 14:5349-5357
Published Date: 2 December 2020
Resveratrol Ameliorates Systemic Sclerosis via Suppression of Fibrosis and Inflammation Through Activation of SIRT1/mTOR Signaling
Yao Q, Wu Q, Xu X, Xing Y, Liang J, Lin Q, Huang M, Chen Y, Lin B, Chen W
Drug Design, Development and Therapy 2020, 14:5337-5348
Published Date: 2 December 2020
Modulation of Drug Release from Natural Polymer Matrices by Response Surface Methodology: in vitro and in vivo Evaluation
Moin A, Gangadharappa HV, Adnan M, Rizvi SM, Ashraf SA, Patel M, Abu Lila AS, Allam AN
Drug Design, Development and Therapy 2020, 14:5325-5336
Published Date: 1 December 2020
Cytotoxic and Antiproliferative Effects of β-Mangostin on Rat C6 Glioma Cells Depend on Oxidative Stress Induction via PI3K/AKT/mTOR Pathway Inhibition
Li K, Wu L, Chen Y, Li Y, Wang Q, Li M, Hao K, Zhang W, Jiang S, Wang Z
Drug Design, Development and Therapy 2020, 14:5315-5324
Published Date: 1 December 2020
Evaluation of the Effect of Hypericum triquetrifolium Turra on Memory Impairment Induced by Chronic Psychosocial Stress in Rats: Role of BDNF
Alzoubi KH, Abdel-Hafiz L, Khabour OF, El-Elimat T, Alzubi MA, Alali FQ
Drug Design, Development and Therapy 2020, 14:5299-5314
Published Date: 1 December 2020
Adjuvant Vaginal Use of Sildenafil Citrate in a Hormone Replacement Cycle Improved Live Birth Rates Among 10,069 Women During First Frozen Embryo Transfers
Tao Y, Wang N
Drug Design, Development and Therapy 2020, 14:5289-5297
Published Date: 1 December 2020
Edaravone and Acetovanillone Upregulate Nrf2 and PI3K/Akt/mTOR Signaling and Prevent Cyclophosphamide Cardiotoxicity in Rats
Hassanein EHM, Abd El-Ghafar OAM, Ahmed MA, Sayed AM, Gad-Elrab WM, Ajarem JS, Allam AA, Mahmoud AM
Drug Design, Development and Therapy 2020, 14:5275-5288
Published Date: 30 November 2020
Characterization of Stable and Reactive Metabolites of the Anticancer Drug, Ensartinib, in Human Liver Microsomes Using LC-MS/MS: An in silico and Practical Bioactivation Approach
Abdelhameed AS, Attwa MW, Kadi AA
Drug Design, Development and Therapy 2020, 14:5259-5273
Published Date: 30 November 2020
Effects of Saikosaponin D on CYP1A2 and CYP2D6 in HepaRG Cells
Li H, Tang Y, Wang Y, Wei W, Yin C, Tang F
Drug Design, Development and Therapy 2020, 14:5251-5258
Published Date: 26 November 2020
Prediction of Targets of Curculigoside A in Osteoporosis and Rheumatoid Arthritis Using Network Pharmacology and Experimental Verification
Han J, Wan M, Ma Z, Hu C, Yi H
Drug Design, Development and Therapy 2020, 14:5235-5250
Published Date: 26 November 2020
Quality by Design (QbD)-Based Numerical and Graphical Optimization Technique for the Development of Osmotic Pump Controlled-Release Metoclopramide HCl Tablets
Farooqi S, Yousuf RI, Shoaib MH, Ahmed K, Ansar S, Husain T
Drug Design, Development and Therapy 2020, 14:5217-5234
Published Date: 26 November 2020
Synergistic Combination Chemotherapy of Lung Cancer: Cisplatin and Doxorubicin Conjugated Prodrug Loaded, Glutathione and pH Sensitive Nanocarriers
Jin Y, Wang Y, Liu X, Zhou J, Wang X, Feng H, Liu H
Drug Design, Development and Therapy 2020, 14:5205-5215
Published Date: 25 November 2020
In Ovo and In Silico Evaluation of the Anti-Angiogenic Potential of Syringin
Aventurado CA, Billones JB, Vasquez RD, Castillo AL
Drug Design, Development and Therapy 2020, 14:5189-5204
Published Date: 25 November 2020
Pharmacokinetic/Pharmacodynamic Interactions Between Evogliptin and Glimepiride in Healthy Male Subjects
Yoo H, Kim Y, Jang IJ, Yu KS, Lee S
Drug Design, Development and Therapy 2020, 14:5179-5187
Published Date: 24 November 2020
Comparison of Bioavailability and Bioequivalence of Generic and Brand Name Formulations of Escitalopram Oxalate Tablets in Healthy Chinese Population Under Fasting and Fed Conditions
Li Q, Huo H, Hu W, Sui Y, Tang Y
Drug Design, Development and Therapy 2020, 14:5167-5177
Published Date: 24 November 2020
Activation of PI3K/Akt/HIF-1α Signaling is Involved in Lung Protection of Dexmedetomidine in Patients Undergoing Video-Assisted Thoracoscopic Surgery: A Pilot Study
Zhu L, Zhang Y, Zhang Z, Ding X, Gong C, Qian Y
Drug Design, Development and Therapy 2020, 14:5155-5166
Published Date: 24 November 2020
Agonism of Gpr40 Protects the Capacities of Epidermal Stem Cells (ESCs) Against Ultraviolet-B (UV-B)
Sun C, Li Y, Li X, Sun J
Drug Design, Development and Therapy 2020, 14:5143-5153
Published Date: 24 November 2020
Functional Measurement of CYP2C9 and CYP3A4 Allelic Polymorphism on Sildenafil Metabolism
Tang P, Zheng X, Hu X, Yang C, Chen Z, Qian J, Cai J, Hu G
Drug Design, Development and Therapy 2020, 14:5129-5141
Published Date: 24 November 2020
In vitro Comparative Quality Assessment of Different Brands of Furosemide Tablets Marketed in Northwest Ethiopia
Abebe S, Ketema G, Kassahun H
Drug Design, Development and Therapy 2020, 14:5119-5128
Published Date: 24 November 2020
Research on the Potential Mechanism of Gentiopicroside Against Gastric Cancer Based on Network Pharmacology
Huang Y, Jiatong Lin, Yi W, Liu Q, Cao L, Yan Y, Fu A, Huang T, Lyu Y, Huang Q, Wang J
Drug Design, Development and Therapy 2020, 14:5109-5118
Published Date: 23 November 2020
COVID-19 Clinical Trials Registered Worldwide for Drug Intervention: An Overview and Characteristic Analysis
Wang B, Lai J, Yan X, Jin F, Yi B, An C, Li Y, Yao C
Drug Design, Development and Therapy 2020, 14:5097-5108
Published Date: 19 November 2020
Loxoprofen Sodium Alleviates Oxidative Stress and Apoptosis Induced by Angiotensin II in Human Umbilical Vein Endothelial Cells (HUVECs)
Ji C, Yu Y, Zhang M, Yu W, Dong S
Drug Design, Development and Therapy 2020, 14:5087-5096
Published Date: 18 November 2020
Acacetin Induces Apoptosis in Human Osteosarcoma Cells by Modulation of ROS/JNK Activation
Wang S, Lin B, Liu W, Wei G, Li Z, Yu N, Xue X, Ji G
Drug Design, Development and Therapy 2020, 14:5077-5085
Published Date: 18 November 2020
QbD-Based Investigation of Dermal Semisolid in situ Film-Forming Systems for Local Anaesthesia
Kovács A, Kis N, Budai-Szűcs M, Gácsi A, Csányi E, Csóka I, Berkó S
Drug Design, Development and Therapy 2020, 14:5059-5076
Published Date: 18 November 2020
Repurposing Anti-Cancer Drugs for COVID-19 Treatment
Borcherding N, Jethava Y, Vikas P
Drug Design, Development and Therapy 2020, 14:5045-5058
Published Date: 18 November 2020
Paeoniflorin Improves Cardiac Function and Decreases Adverse Postinfarction Left Ventricular Remodeling in a Rat Model of Acute Myocardial Infarction [Corrigendum]
Chen H, Dong Y, He X, Li J, Wang J
Drug Design, Development and Therapy 2020, 14:5043-5044
Published Date: 18 November 2020
Efficacy and Safety of Supplemental Transarterial Chemoembolization Through Extrahepatic Collateral Arteries with Drug-eluting Beads: Treatment for Unresectable Hepatocellular Carcinoma
Chiu SH, Chang PY, Shih YL, Huang WY, Ko KH, Chang WC, Huang GS
Drug Design, Development and Therapy 2020, 14:5029-5041
Published Date: 17 November 2020
Casticin Improves Respiratory Dysfunction and Attenuates Oxidative Stress and Inflammation via Inhibition of NF-ĸB in a Chronic Obstructive Pulmonary Disease Model of Chronic Cigarette Smoke-Exposed Rats
Li J, Qiu C, Xu P, Lu Y, Chen RC
Drug Design, Development and Therapy 2020, 14:5019-5027
Published Date: 17 November 2020
Efficacy and Safety of Nebivolol and Rosuvastatin Combination Treatment in Patients with Concomitant Hypertension and Hyperlipidemia
Rhee MY, Kim CH, Ahn Y, Shin JH, Han SH, Kang HJ, Hong SJ, Kim HY
Drug Design, Development and Therapy 2020, 14:5005-5017
Published Date: 17 November 2020
Synthesis and Cytotoxic Property of Annonaceous Acetogenin Glycoconjugates
Shi JF, Wu P, Cheng XL, Wei XY, Jiang ZH
Drug Design, Development and Therapy 2020, 14:4993-5004
Published Date: 17 November 2020
Therapeutic Effects of Modified Gengnianchun Formula on Stress-Induced Diminished Ovarian Reserve Based on Experimental Approaches and Network Pharmacology
Gao L, Zhang Y, Xu H, Zhao F, Wang W
Drug Design, Development and Therapy 2020, 14:4975-4992
Published Date: 17 November 2020
Palmatine as an Agent Against Metabolic Syndrome and Its Related Complications: A Review
Ekeuku SO, Pang KL, Chin KY
Drug Design, Development and Therapy 2020, 14:4963-4974
Published Date: 17 November 2020
Chrysophanol Inhibits the Progression of Diabetic Nephropathy via Inactivation of TGF-β Pathway
Guo C, Wang Y, Piao Y, Rao X, Yin D
Drug Design, Development and Therapy 2020, 14:4951-4962
Published Date: 16 November 2020
HIF-1α is a Potential Molecular Target for Herbal Medicine to Treat Diseases
Li RL, He LY, Zhang Q, Liu J, Lu F, Duan HXY, Fan LH, Peng W, Huang YL, Wu CJ
Drug Design, Development and Therapy 2020, 14:4915-4949
Published Date: 16 November 2020
Eldecalcitol Inhibits LPS-Induced NLRP3 Inflammasome-Dependent Pyroptosis in Human Gingival Fibroblasts by Activating the Nrf2/HO-1 Signaling Pathway
Huang C, Zhang C, Yang P, Chao R, Yue Z, Li C, Guo J, Li M
Drug Design, Development and Therapy 2020, 14:4901-4913
Published Date: 13 November 2020
iTRAQ-Based Quantitative Proteomic Analysis of Intestines in Murine Polymicrobial Sepsis with Hydrogen Gas Treatment
Jiang Y, Bian Y, Lian N, Wang Y, Xie K, Qin C, Yu Y
Drug Design, Development and Therapy 2020, 14:4885-4900
Published Date: 12 November 2020
Comparative Analysis of the Effectiveness of Some Biological Injected Wound Healing Stimulators and Criteria for Its Evaluation
Silina EV, Manturova NE, Litvitskiy PF, Stupin VA
Drug Design, Development and Therapy 2020, 14:4869-4883
Published Date: 12 November 2020
Indole: The After Next Scaffold of Antiplasmodial Agents?
Surur AS, Huluka SA, Mitku ML, Asres K
Drug Design, Development and Therapy 2020, 14:4855-4867
Published Date: 11 November 2020
Downregulation of miR-200a Protects Mouse Leydig Cells Against Triptolide by Triggering Autophagy
Miao H, Miao C, Han J, Li N
Drug Design, Development and Therapy 2020, 14:4845-4854
Published Date: 10 November 2020
Development and Validation of UHPLC-MS/MS Assay for Therapeutic Drug Monitoring of High-dose Methotrexate in Children with Acute Lymphoblastic Leukemia
Lian LJ, Lin B, Cui X, He J, Wang Z, Lin XD, Ye WJ, Chen RJ, Sun W
Drug Design, Development and Therapy 2020, 14:4835-4843
Published Date: 10 November 2020
Intermedin Alleviates Renal Ischemia-Reperfusion Injury and Enhances Neovascularization in Wistar Rats
Wang Y, Mi Y, Tian J, Qiao X, Su X, Kang J, Wu Z, Wang G, Zhou X, Zhou Y, Li R
Drug Design, Development and Therapy 2020, 14:4825-4834
Published Date: 10 November 2020
In Vitro and In Vivo Rat Model Assessments of the Effects of Vonoprazan on the Pharmacokinetics of Venlafaxine
Chen F, Jiang H, Xu J, Wang S, Meng D, Geng P, Dai D, Zhou Q, Zhou Y
Drug Design, Development and Therapy 2020, 14:4815-4824
Published Date: 10 November 2020
Acacetin Alleviates Inflammation and Matrix Degradation in Nucleus Pulposus Cells and Ameliorates Intervertebral Disc Degeneration in vivo
Wang H, Jiang Z, Pang Z, Zhou T, Gu Y
Drug Design, Development and Therapy 2020, 14:4801-4813
Published Date: 10 November 2020
LncRNA KCNQ1OT1 Sponges miR-206 to Ameliorate Neural Injury Induced by Anesthesia via Up-Regulating BDNF
Yao Y, Wang X, Gao J
Drug Design, Development and Therapy 2020, 14:4789-4800
Published Date: 9 November 2020
SGLT2 Inhibitors: A Novel Player in the Treatment and Prevention of Diabetic Cardiomyopathy
Li N, Zhou H
Drug Design, Development and Therapy 2020, 14:4775-4788
Published Date: 6 November 2020
Effects of Snake-Derived Phospholipase A2 Inhibitors on Acute Pancreatitis: In vitro and in vivo Characterization
Wu Y, Liao GY, Ke HJ, Liu P
Drug Design, Development and Therapy 2020, 14:4765-4774
Published Date: 6 November 2020
Homoharringtonine Exerts an Antimyeloma Effect by Promoting Excess Parkin-Dependent Mitophagy
Zhang Y, Huang N, Xu J, Zheng W, Cui X
Drug Design, Development and Therapy 2020, 14:4749-4763
Published Date: 5 November 2020
Pharmacological Activity and Mechanism of Tanshinone IIA in Related Diseases
Guo R, Li L, Su J, Li S, Duncan SE, Liu Z, Fan G
Drug Design, Development and Therapy 2020, 14:4735-4748
Published Date: 5 November 2020
Sanguinarine Attenuates Neuropathic Pain by Inhibiting P38 MAPK Activated Neuroinflammation in Rat Model
Yu C, Li P, Wang YX, Zhang KG, Zheng ZC, Liang LS
Drug Design, Development and Therapy 2020, 14:4725-4733
Published Date: 4 November 2020
Interaction of Analgesic Effects of Dezocine and Sufentanil for Relief of Postoperative Pain: A Pilot Study
Zhu H, Chen Y, Huang S, Sun X
Drug Design, Development and Therapy 2020, 14:4717-4724
Published Date: 3 November 2020
Cerebral Oxygen Changes in Neonates During Immediate Transition After Birth and Early Life: An Observational Study
Xue H, Wu Z, Yao J, Zhao A, Zheng L, Yin X, Wang F, Zhao P
Drug Design, Development and Therapy 2020, 14:4703-4715
Published Date: 2 November 2020
Impact of Dexmedetomidine Infusion on Postoperative Acute Kidney Injury in Elderly Patients Undergoing Major Joint Replacement: A Retrospective Cohort Study
Zhu H, Ren A, Zhou K, Chen Q, Zhang M, Liu J
Drug Design, Development and Therapy 2020, 14:4695-4701
Published Date: 2 November 2020
In vitro and in vivo Effects of Artesunate on Echinococcus granulosus Protoscoleces and Metacestodes
Wen L, Lv G, Zhao J, Lu S, Gong Y, Li Y, Zheng H, Chen B, Gao H, Tian C, Wang J
Drug Design, Development and Therapy 2020, 14:4685-4694
Published Date: 2 November 2020
The Effects of Short-Chain Fatty Acids on Rat Colonic Hypermotility Induced by Water Avoidance Stress
Yuan F, Tan W, Ren H, Yan L, Wang Y, Luo H
Drug Design, Development and Therapy 2020, 14:4671-4684
Published Date: 2 November 2020
Pristimerin Suppresses Trophoblast Cell Epithelial–Mesenchymal Transition via miR-542-5p/EGFR Axis
Shu C, Yu X, Cheng S, Jing J, Hu C, Pang B
Drug Design, Development and Therapy 2020, 14:4659-4670
Published Date: 2 November 2020
Stoichiometrically Governed Curcumin Solid Dispersion and Its Cytotoxic Evaluation on Colorectal Adenocarcinoma Cells
Mohamed JMM, Alqahtani A, Ahmad F, Krishnaraju V, Kalpana K
Drug Design, Development and Therapy 2020, 14:4639-4658
Published Date: 2 November 2020
Cinnamaldehyde Inhibits the Function of Osteosarcoma by Suppressing the Wnt/β-Catenin and PI3K/Akt Signaling Pathways
Huang Y, Chen J, Yang S, Tan T, Wang N, Wang Y, Zhang L, Yang C, Huang H, Luo J, Luo X
Drug Design, Development and Therapy 2020, 14:4625-4637
Published Date: 30 October 2020
A Comprehensive Review on Pharmaceutical Film Coating: Past, Present, and Future
Zaid AN
Drug Design, Development and Therapy 2020, 14:4613-4623
Published Date: 29 October 2020
The HSP90 Inhibitor, 17-AAG, Influences the Activation and Proliferation of T Lymphocytes via AKT/GSK3β Signaling in MRL/lpr Mice
Hong LJ, Chen AJ, Li FZ, Chen KJ, Fang S
Drug Design, Development and Therapy 2020, 14:4605-4612
Published Date: 29 October 2020
Tranilast Inhibits Pulmonary Fibrosis by Suppressing TGFβ/SMAD2 Pathway
Kato M, Takahashi F, Sato T, Mitsuishi Y, Tajima K, Ihara H, Nurwidya F, Baskoro H, Murakami A, Kobayashi I, Hidayat M, Shimada N, Sasaki S, Mineki R, Fujimura T, Kumasaka T, Niwa SI, Takahashi K
Drug Design, Development and Therapy 2020, 14:4593-4603
Published Date: 29 October 2020
Osteogenic Effect of tsRNA-10277-Loaded Exosome Derived from Bone Mesenchymal Stem Cells on Steroid-Induced Osteonecrosis of the Femoral Head
Fang S, He T, Jiang J, Li Y, Chen P
Drug Design, Development and Therapy 2020, 14:4579-4591
Published Date: 28 October 2020
Anti-Breast Cancer Effect of 2-Dodecyl-6-Methoxycyclohexa-2,5-Diene-1,4-Dione in vivo and in vitro Through MAPK Signaling Pathway [Corrigendum]
Zhou X, Wu X, Qin L, Lu S, Zhang H, Wei J, Chen L, Jiang L, Wu Y, Chen C, Huang R
Drug Design, Development and Therapy 2020, 14:4575-4577
Published Date: 28 October 2020
Pseudolaric Acid B Inhibits Proliferation, Invasion, and Angiogenesis in Esophageal Squamous Cell Carcinoma Through Regulating CD147
Yin Z, Cai H, Wang Z, Jiang Y
Drug Design, Development and Therapy 2020, 14:4561-4573
Published Date: 28 October 2020
Novel Fast and Reliable Method for Nano-Erythrosome Production Using Shear Force
Capossela S, Mathew V, Boos M, Bertolo A, Krupkova O, Stoyanov JV
Drug Design, Development and Therapy 2020, 14:4547-4560
Published Date: 28 October 2020
S-Allylmercaptocysteine Targets Nrf2 in Osteoarthritis Treatment Through NOX4/NF-κB Pathway
Yang G, Sun S, Wang J, Li W, Wang X, Yuan L, Li S
Drug Design, Development and Therapy 2020, 14:4533-4546
Published Date: 28 October 2020
Lung Cancer Combination Treatment: Evaluation of the Synergistic Effect of Cisplatin Prodrug, Vinorelbine and Retinoic Acid When Co-Encapsulated in a Multi-Layered Nano-Platform
Liang Z, Li J, Zhu B
Drug Design, Development and Therapy 2020, 14:4519-4531
Published Date: 27 October 2020
Analgesic and Antiallodynic Effects of 4-Fluoro-N-(4-Sulfamoylbenzyl) Benzene Sulfonamide in a Murine Model of Pain
Ur Rehman N, al-Rashida M, Tokhi A, Ahmed Z, Subhan F, Abbas M, Arshid MA, Rauf K
Drug Design, Development and Therapy 2020, 14:4511-4518
Published Date: 27 October 2020
Co-Delivery Anticancer Drug Nanoparticles for Synergistic Therapy Against Lung Cancer Cells
Shen Y, TanTai J
Drug Design, Development and Therapy 2020, 14:4503-4510
Published Date: 23 October 2020
Pharmacokinetic/Pharmacodynamic Interaction Between Evogliptin and Pioglitazone in Healthy Male Subjects
Hwang I, Kim Y, Yoo H, Jang IJ, Yu KS, Lee S
Drug Design, Development and Therapy 2020, 14:4493-4502
Published Date: 23 October 2020
Synthesis, Cytotoxic Analysis, and Molecular Docking Studies of Tetrazole Derivatives via N-Mannich Base Condensation as Potential Antimicrobials
Atef Hatamleh A, Al Farraj D, Salah Al-Saif S, Chidambaram S, Radhakrishnan S, Akbar I
Drug Design, Development and Therapy 2020, 14:4477-4492
Published Date: 23 October 2020
Enhancement of Pancreatic Cancer Therapy Efficacy by Type-1 Matrix Metalloproteinase-Functionalized Nanoparticles for the Selective Delivery of Gemcitabine and Erlotinib
Yin N, Yu H, Zhang X, Lv X
Drug Design, Development and Therapy 2020, 14:4465-4475
Published Date: 23 October 2020
Resveratrol Protects Osteoblasts Against Dexamethasone-Induced Cytotoxicity Through Activation of AMP-Activated Protein Kinase
Wang L, Li Q, Yan H, Jiao G, Wang H, Chi H, Zhou H, Chen L, Shan Y, Chen Y
Drug Design, Development and Therapy 2020, 14:4451-4463
Published Date: 23 October 2020
LC-MS/MS Estimation of the Anti-Cancer Agent Tandutinib Levels in Human Liver Microsomes: Metabolic Stability Evaluation Assay
Attwa MW, Abdelhameed AS, Al-Shakliah NS, Kadi AA
Drug Design, Development and Therapy 2020, 14:4439-4449
Published Date: 23 October 2020
Metabolic Activation and Covalent Protein Binding of Berberrubine: Insight into the Underlying Mechanism Related to Its Hepatotoxicity
Wang K, Rao J, Zhang T, Gao Q, Zhang J, Guang C, Ding L, Qiu F
Drug Design, Development and Therapy 2020, 14:4423-4438
Published Date: 22 October 2020
Alprostadil Injection Attenuates Coronary Microembolization-Induced Myocardial Injury Through GSK-3β/Nrf2/HO-1 Signaling-Mediated Apoptosis Inhibition
Qin Z, Kong B, Zheng J, Wang X, Li L
Drug Design, Development and Therapy 2020, 14:4407-4422
Published Date: 22 October 2020
Enteric-Coated Strategies in Colorectal Cancer Nanoparticle Drug Delivery System
Wathoni N, Nguyen AN, Rusdin A, Umar AK, Mohammed AFA, Motoyama K, Joni IM, Muchtaridi M
Drug Design, Development and Therapy 2020, 14:4387-4405
Published Date: 21 October 2020
Validated Microwell-Based Spectrofluorimetric Method for Quantification of Ravidasvir (New Anti-Chronic Hepatitis C Virus-GT4) in Rat Plasma and Its Application to Pharmacokinetic Study
Hefnawy M, Al-Shehri M, Al-Rashood S, Hammad S, Alanazi M, Alsaif N, Mohammed M, Obaidullah A, El-Gendy M
Drug Design, Development and Therapy 2020, 14:4377-4385
Published Date: 20 October 2020
ISL Induces Apoptosis and Autophagy in Hepatocellular Carcinoma via Downregulation of PI3K/AKT/mTOR Pathway in vivo and in vitro
Song L, Luo Y, Li S, Hong M, Wang Q, Chi X, Yang C
Drug Design, Development and Therapy 2020, 14:4363-4376
Published Date: 20 October 2020
Development, Characterization, and in-vivo Pharmacokinetic Study of Lamotrigine Solid Self-Nanoemulsifying Drug Delivery System
Abdelmonem R, Azer MS, Makky A, Zaghloul A, El-Nabarawi M, Nada A
Drug Design, Development and Therapy 2020, 14:4343-4362
Published Date: 19 October 2020
Proteasome, a Promising Therapeutic Target for Multiple Diseases Beyond Cancer
Cao Y, Zhu H, He R, Kong L, Shao J, Zhuang R, Xi J, Zhang J
Drug Design, Development and Therapy 2020, 14:4327-4342
Published Date: 19 October 2020
Synthesis and Identification of a Novel Peptide, Ac-SDK (Biotin) Proline, That Can Elicit Anti-Fibrosis Effects in Rats Suffering from Silicosis
Wang J, Qian Y, Gao X, Mao N, Geng Y, Lin G, Zhang G, Li H, Yang F, Xu H
Drug Design, Development and Therapy 2020, 14:4315-4326
Published Date: 19 October 2020
Simvastatin-Nicotinamide Co-Crystals: Formation, Pharmaceutical Characterization and in vivo Profile
Khan FM, Ahmad M, Idrees HA
Drug Design, Development and Therapy 2020, 14:4303-4313
Published Date: 19 October 2020
HLJ2 Effectively Ameliorates Colitis-Associated Cancer via Inhibition of NF-κB and Epithelial–Mesenchymal Transition
Song H, Tang X, Li X, Wang Y, Deng A, Wang W, Zhang H, Qin H, Wu LQ
Drug Design, Development and Therapy 2020, 14:4291-4302
Published Date: 15 October 2020
Bucco-Adhesive Film as a Pediatric Proper Dosage Form for Systemic Delivery of Propranolol Hydrochloride: In-vitro and in-vivo Evaluation
Mohamad SA, Salem H, Yassin HA, Mansour HF
Drug Design, Development and Therapy 2020, 14:4277-4289
Published Date: 15 October 2020
Effects of Anisodine Hydrobromide on the Cardiovascular and Respiratory Functions in Conscious Dogs
Liu Y, Wang L, Wan F, Yang N
Drug Design, Development and Therapy 2020, 14:4263-4276
Published Date: 13 October 2020
EGCG Upregulates UCP3 Levels to Protect MIN6 Pancreatic Islet Cells from Interleukin-1β-Induced Apoptosis
Jia X, Luo Z, Gao Y, Liu H, Liu X, Mai W, Liu H, Zheng Q
Drug Design, Development and Therapy 2020, 14:4251-4261
Published Date: 13 October 2020
The Potential Roles of Epigallocatechin-3-Gallate in the Treatment of Ovarian Cancer: Current State of Knowledge
Bimonte S, Cascella M
Drug Design, Development and Therapy 2020, 14:4245-4250
Published Date: 12 October 2020
Dexmedetomidine Attenuates Cellular Injury and Apoptosis in H9c2 Cardiomyocytes by Regulating p-38MAPK and Endoplasmic Reticulum Stress
Zhu Z, Ling X, Zhou H, Zhang C, Yan W
Drug Design, Development and Therapy 2020, 14:4231-4243
Published Date: 12 October 2020
Pharmacokinetics and Bioequivalence of Two Formulations of Valsartan 80 mg Capsules: A Randomized, Single Dose, 4-Period Crossover Study in Healthy Chinese Volunteers Under Fasting and Fed Conditions
Wu Q, Wang X, Chen Q, Zou Y, Xu X, Li T, Yu C, Zhu F, Zhang KE, Jia J, Liu Y
Drug Design, Development and Therapy 2020, 14:4221-4230
Published Date: 12 October 2020
Clinical Outcome of Systemic Treatment for Advanced Soft Tissue Sarcoma: Real-Life Perspective in Japan
Nakamura T, Asanuma K, Hagi T, Sudo A
Drug Design, Development and Therapy 2020, 14:4215-4220
Published Date: 12 October 2020
Effect of Platelet-Activating Factor on Barrier Function of ARPE-19 Cells
Zhang F, Liu L, Zhang H, Liu ZL
Drug Design, Development and Therapy 2020, 14:4205-4214
Published Date: 12 October 2020
Pristimerin Inhibits Osteoclast Differentiation and Bone Resorption in vitro and Prevents Ovariectomy-Induced Bone Loss in vivo
Sun P, Yang Q, Wang Y, Peng J, Zhao K, Jia Y, Zhang T, Lu X, Han W, Qian Y
Drug Design, Development and Therapy 2020, 14:4189-4203
Published Date: 9 October 2020
Physical Compatibility and Chemical Stability of Fentanyl and Naloxone Hydrochloride in 0.9% Sodium Chloride Injection Solution for Patient-Controlled Analgesia Administration
Chen P, Chen F, Lei J, Zhou B
Drug Design, Development and Therapy 2020, 14:4179-4187
Published Date: 9 October 2020
The Impact of Icariside II on Human Prostate Cancer Cell Proliferation, Mobility, and Autophagy via PI3K-AKT-mTOR Signaling Pathway
Li S, Zhan Y, Xie Y, Wang Y, Liu Y
Drug Design, Development and Therapy 2020, 14:4169-4178
Published Date: 8 October 2020
Novel Molecular Mechanism of Aspirin and Celecoxib Targeting Mammalian Neuraminidase-1 Impedes Epidermal Growth Factor Receptor Signaling Axis and Induces Apoptosis in Pancreatic Cancer Cells
Qorri B, Harless W, Szewczuk MR
Drug Design, Development and Therapy 2020, 14:4149-4167
Published Date: 8 October 2020
Wogonin Ameliorates Renal Inflammation and Fibrosis by Inhibiting NF-κB and TGF-β1/Smad3 Signaling Pathways in Diabetic Nephropathy
Zheng Z, Zhu W, Lei L, Liu X, Wu Y
Drug Design, Development and Therapy 2020, 14:4135-4148
Published Date: 8 October 2020
Cordycepin Alleviates Anterior Cruciate Ligament Transection (ACLT)-Induced Knee Osteoarthritis Through Regulating TGF-β Activity and Autophagy [Retraction]
Tao XM, Liu PF, Gu HY, Lian DB, Gao L, Tao WW, Yan D, Zhao B
Drug Design, Development and Therapy 2020, 14:4133-4134
Published Date: 7 October 2020
Ginkgolide B Ameliorates Myocardial Ischemia Reperfusion Injury in Rats via Inhibiting Endoplasmic Reticulum Stress [Retraction]
Guo C, Zhang J, Zhang P, Si A, Zhang Z, Zhao L, Lv F, Zhao G
Drug Design, Development and Therapy 2020, 14:4131-4132
Published Date: 7 October 2020
Charge Transfer Complex of Neostigmine with 2,3-Dichloro-5,6-Dicyano-1,4-Benzoquinone: Synthesis, Spectroscopic Characterization, Antimicrobial Activity, and Theoretical Study
Yousef TA, Ezzeldin E, Abdel-Aziz HA, Al-Agamy MH, Mostafa GAE
Drug Design, Development and Therapy 2020, 14:4115-4129
Published Date: 6 October 2020
Dexamethasone-Loaded Thermosensitive Hydrogel Suppresses Inflammation and Pain in Collagen-Induced Arthritis Rats
Wang QS, Xu BX, Fan KJ, Li YW, Wu J, Wang TY
Drug Design, Development and Therapy 2020, 14:4101-4113
Published Date: 5 October 2020
[6]-Gingerol Ameliorates Cisplatin-Induced Pica by Regulating the TPH/MAO-A/SERT/5-HT/5-HT3 Receptor System in Rats
Cheng Q, Feng X, Meng Q, Li Y, Chen Siqi, Wang G, Nie K
Drug Design, Development and Therapy 2020, 14:4085-4099
Published Date: 2 October 2020
Integrated Network Pharmacology Analysis and Experimental Validation to Reveal the Mechanism of Anti-Insulin Resistance Effects of Moringa oleifera Seeds
Huang Q, Liu R, Liu J, Huang Q, Liu S, Jiang Y
Drug Design, Development and Therapy 2020, 14:4069-4084
Published Date: 2 October 2020
Integrated Network Pharmacology Analysis and Pharmacological Evaluation to Explore the Active Components and Mechanism of Abelmoschus manihot (L.) Medik. on Renal Fibrosis
Gu L, Hong F, Fan K, Zhao L, Zhang C, Yu B, Chai C
Drug Design, Development and Therapy 2020, 14:4053-4067
Published Date: 1 October 2020
A Review on the Role of Denosumab in Fracture Prevention
Pang KL, Low NY, Chin KY
Drug Design, Development and Therapy 2020, 14:4029-4051
Published Date: 1 October 2020
Multifunctional Islet Transplantation Hydrogel Encapsulating A20 High-Expressing Islets
Bai X, Pei Q, Pu C, Chen Y, He S, Wang B
Drug Design, Development and Therapy 2020, 14:4021-4027
Published Date: 29 September 2020
RETRACTED ARTICLE: Umbelliferone Inhibits Spermatogenic Defects and Testicular Injury in Lead-Intoxicated Rats by Suppressing Oxidative Stress and Inflammation, and Improving Nrf2/HO-1 Signaling
Alotaibi MF, Al-Joufi F, Abou Seif HS, Alzoghaibi MA, Djouhri L, Ahmeda AF, Mahmoud AM
Drug Design, Development and Therapy 2020, 14:4003-4019
Published Date: 29 September 2020
Challenges for Mesenchymal Stem Cell-Based Therapy for COVID-19
Li C, Zhao H, Wang B
Drug Design, Development and Therapy 2020, 14:3995-4001
Published Date: 29 September 2020
Identification of a Novel c-Myc Inhibitor 7594-0037 by Structure-Based Virtual Screening and Investigation of Its Anti-Cancer Effect on Multiple Myeloma
Yao R, Xie Y, Sun X, Zhang M, Zhou J, Liu L, Gao J, Xu K
Drug Design, Development and Therapy 2020, 14:3983-3993
Published Date: 28 September 2020
Acquired Hypothyroidism in Patients with Metastatic Renal Cell Carcinoma Treated with Tyrosine Kinase Inhibitors
Wu J, Huang H
Drug Design, Development and Therapy 2020, 14:3977-3982
Published Date: 28 September 2020
Anti-Tumor Xanthones from Garcinia nujiangensis Suppress Proliferation, and Induce Apoptosis via PARP, PI3K/AKT/mTOR, and MAPK/ERK Signaling Pathways in Human Ovarian Cancers Cells
Tang Z, Lu L, Xia Z
Drug Design, Development and Therapy 2020, 14:3965-3976
Published Date: 25 September 2020
Knockdown of hsa_circ_0059955 Induces Apoptosis and Cell Cycle Arrest in Nucleus Pulposus Cells via Inhibiting Itchy E3 Ubiquitin Protein Ligase
Kong D, Gu R, Zhang C, Yin R
Drug Design, Development and Therapy 2020, 14:3951-3963
Published Date: 25 September 2020
The Activity and Safety of Anlotinib for Patients with Extremity Desmoid Fibromatosis: A Retrospective Study in a Single Institution
Zheng C, Zhou Y, Wang Y, Luo Y, Tu C, Min L
Drug Design, Development and Therapy 2020, 14:3941-3950
Published Date: 25 September 2020
DPP-4 Inhibitor Linagliptin Ameliorates Oxidized LDL-Induced THP-1 Macrophage Foam Cell Formation and Inflammation
Wang H, Li Y, Zhang X, Xu Z, Zhou J, Shang W
Drug Design, Development and Therapy 2020, 14:3929-3940
Published Date: 25 September 2020
Antiemetic Prophylaxis with Fosaprepitant and 5-HT3-Receptor Antagonists in Pediatric Patients Undergoing Autologous Hematopoietic Stem Cell Transplantation
Cabanillas Stanchi KM, Willier S, Vek J, Schlegel P, Queudeville M, Rieflin N, Klaus V, Gansel M, Rupprecht JV, Flaadt T, Binder V, Feuchtinger T, Lang P, Handgretinger R, Döring M
Drug Design, Development and Therapy 2020, 14:3915-3927
Published Date: 25 September 2020
Integrating Unified Medical Language System and Kleinberg’s Burst Detection Algorithm into Research Topics of Medications for Post-Traumatic Stress Disorder
Xu S, Xu D, Wen L, Zhu C, Yang Y, Han S, Guan P
Drug Design, Development and Therapy 2020, 14:3899-3913
Published Date: 24 September 2020
Effects of High-Dose Rosuvastatin on Ventricular Remodelling and Cardiac Function in ST-Segment Elevation Myocardial Infarction
Luo R, Sun X, Shen F, Hong B, Wang Z
Drug Design, Development and Therapy 2020, 14:3891-3898
Published Date: 23 September 2020
Recent Progress in the Development of New Antimalarial Drugs with Novel Targets
Belete TM
Drug Design, Development and Therapy 2020, 14:3875-3889
Published Date: 22 September 2020
Phoenixin 14 Inhibits High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Experimental Mice
Yang F, Huang P, Shi L, Liu F, Tang A, Xu S
Drug Design, Development and Therapy 2020, 14:3865-3874
Published Date: 22 September 2020
Protective Effect of Pravastatin on Myocardial Ischemia Reperfusion Injury by Regulation of the miR-93/Nrf2/ARE Signal Pathway
Liu Z, Zhang F, Zhao L, Zhang X, Li Y, Liu L
Drug Design, Development and Therapy 2020, 14:3853-3864
Published Date: 22 September 2020
Synergistic Cytotoxic Effect from Combination of Wedelolactone and Cisplatin in HeLa Cell Line: A Novel Finding
Sarwar S, Yu JQ, Nadeem H, Huq F
Drug Design, Development and Therapy 2020, 14:3841-3852
Published Date: 22 September 2020
Hydrogen-Rich Saline Regulates Microglial Phagocytosis and Restores Behavioral Deficits Following Hypoxia-Ischemia Injury in Neonatal Mice via the Akt Pathway
Ke H, Liu D, Li T, Chu X, Xin D, Han M, Wang S, Wang Z
Drug Design, Development and Therapy 2020, 14:3827-3839
Published Date: 21 September 2020
Quercetin Inhibits Adenomyosis by Attenuating Cell Proliferation, Migration and Invasion of Ectopic Endometrial Stromal Cells
Xu W, Song Y, Li K, Zhang B, Zhu X
Drug Design, Development and Therapy 2020, 14:3815-3826
Published Date: 21 September 2020
Study Design Characteristics and Pharmacological Mechanisms in International Clinical Trials Registry Platform: Registered Clinical Trials on Antiviral Drugs for COVID-19
Zhang W, Lv Y, Yang J, Chen Y, He Y, Huang J
Drug Design, Development and Therapy 2020, 14:3803-3813
Published Date: 18 September 2020
Bacterial Natural Compounds with Anti-Inflammatory and Immunomodulatory Properties (Mini Review)
Jenab A, Roghanian R, Emtiazi G
Drug Design, Development and Therapy 2020, 14:3787-3801
Published Date: 18 September 2020
Effect of 4-Fluoro-N-(4-Sulfamoylbenzyl) Benzene Sulfonamide on Acquisition and Expression of Nicotine-Induced Behavioral Sensitization and Striatal Adenosine Levels
Ur Rehman N, Abbas M, al-Rashida M, Tokhi A, Arshid MA, Khan MS, Ahmad I, Rauf K
Drug Design, Development and Therapy 2020, 14:3777-3786
Published Date: 17 September 2020
Exosomes Derived from Mesenchymal Stem Cells Protect the Myocardium Against Ischemia/Reperfusion Injury Through Inhibiting Pyroptosis
Tang J, Jin L, Liu Y, Li L, Ma Y, Lu L, Ma J, Ding P, Yang X, Liu J, Yang J
Drug Design, Development and Therapy 2020, 14:3765-3775
Published Date: 16 September 2020
The Potential Effects of Aliskiren on Atrial Remodeling Induced by Chronic Intermittent Hypoxia in Rats
Miao S, Yang Y, Li R, Yin L, Zhang K, Cheng L, Xu X, Wang W, Zhao Z, Li G
Drug Design, Development and Therapy 2020, 14:3755-3764
Published Date: 16 September 2020
Spotlight on Mogamulizumab-Kpkc for Use in Adults with Relapsed or Refractory Mycosis Fungoides or Sézary Syndrome: Efficacy, Safety, and Patient Selection
Blackmon AL, Pinter-Brown L
Drug Design, Development and Therapy 2020, 14:3747-3754
Published Date: 16 September 2020
Astragaloside IV: An Effective Drug for the Treatment of Cardiovascular Diseases
Tan YQ, Chen HW, Li J
Drug Design, Development and Therapy 2020, 14:3731-3746
Published Date: 15 September 2020
Synthesis and Bioactivity of N-(4-Chlorophenyl)-4-Methoxy-3-(Methylamino) Benzamide as a Potential Anti-HBV Agent
Cui AL, Sun WF, Zhong ZJ, Jin J, Xue ST, Wu S, Li YH, Li ZR
Drug Design, Development and Therapy 2020, 14:3723-3729
Published Date: 15 September 2020
Formulation of Nanospanlastics as a Promising Approach for Improving the Topical Delivery of a Natural Leukotriene Inhibitor (3-Acetyl-11-Keto-β-Boswellic Acid): Statistical Optimization, in vitro Characterization, and ex vivo Permeation Study
Badria F, Mazyed E
Drug Design, Development and Therapy 2020, 14:3697-3721
Published Date: 15 September 2020
LncRNA SNHG4 Attenuates Inflammatory Responses by Sponging miR-449c-5p and Up-Regulating STAT6 in Microglial During Cerebral Ischemia-Reperfusion Injury
Zhang S, Sun W, Liang Z, Yin X, Ji Z, Chen X, Wei M, Pei L
Drug Design, Development and Therapy 2020, 14:3683-3695
Published Date: 11 September 2020
Comparison of GnRH-a Prolonged Protocol and Short GnRH-a Long Protocol in Patients with Thin Endometrium for Assisted Reproduction: A Retrospective Cohort Study
Song J, Duan C, Cai W, Wu W, Lv H, Xu J
Drug Design, Development and Therapy 2020, 14:3673-3682
Published Date: 11 September 2020
Emodin Reverses the Epithelial–Mesenchymal Transition of Human Endometrial Stromal Cells by Inhibiting ILK/GSK-3β Pathway
Zheng Q, Wang J, Li W, Chen X, Chen S, Chen L
Drug Design, Development and Therapy 2020, 14:3663-3672
Published Date: 10 September 2020
Knockdown of lncRNA HOXA-AS3 Suppresses the Progression of Atherosclerosis via Sponging miR-455-5p
Chi K, Zhang J, Sun H, Liu Y, Li Y, Yuan T, Zhang F
Drug Design, Development and Therapy 2020, 14:3651-3662
Published Date: 9 September 2020
Research Status and Outlook of PD-1/PD-L1 Inhibitors for Cancer Therapy
Ai L, Chen J, Yan H, He Q, Luo P, Xu Z, Yang X
Drug Design, Development and Therapy 2020, 14:3625-3649
Published Date: 8 September 2020
Investigation of Inhibition Effect of Gossypol-Acetic Acid on Gastric Cancer Cells Based on a Network Pharmacology Approach and Experimental Validation
Liu Y, Ma Y, Li Z, Yang Y, Yu B, Zhang Z, Wang G
Drug Design, Development and Therapy 2020, 14:3615-3623
Published Date: 7 September 2020
Computational and Pharmacological Investigation of (E)-2-(4-Methoxybenzylidene)Cyclopentanone for Therapeutic Potential in Neurological Disorders
Farooq S, Khan A, Iqbal MS
Drug Design, Development and Therapy 2020, 14:3601-3614
Published Date: 7 September 2020
Enhancing the Butyrylcholinesterase Activity in HEK-293 Cell Line by Dual-Promoter Vector Decorated on Lipofectamine
Mirzaie V, Eslaminejad T, Babaei H, Nematollahi-Mahani SN
Drug Design, Development and Therapy 2020, 14:3589-3599
Published Date: 4 September 2020
Pinocembrin Ameliorates Cognitive Impairment Induced by Vascular Dementia: Contribution of Reelin-dab1 Signaling Pathway
Kang ZC, Wang HG, Yang YL, Zhao XY, Zhou QM, Yang YL, Yang JY, Du GH
Drug Design, Development and Therapy 2020, 14:3577-3587
Published Date: 4 September 2020
Emodin Retarded Renal Fibrosis Through Regulating HGF and TGFβ–Smad Signaling Pathway
Yang F, Deng L, Li J, Chen M, Liu Y, Hu Y, Zhong W
Drug Design, Development and Therapy 2020, 14:3567-3575
Published Date: 3 September 2020
Ketamine Enhances Intranasal Dexmedetomidine-Induced Sedation in Children: A Randomized, Double-Blind Trial
Qian B, Zheng W, Shi J, Chen Z, Guo Y, Yao Y
Drug Design, Development and Therapy 2020, 14:3559-3565
Published Date: 26 August 2020
LncRNA PVT1 Suppresses the Progression of Renal Fibrosis via Inactivation of TGF-β Signaling Pathway
Cao L, Qin P, Zhang J, Qiao H, Shi P, Huo H
Drug Design, Development and Therapy 2020, 14:3547-3557
Published Date: 26 August 2020
Fatostatin in Combination with Tamoxifen Induces Synergistic Inhibition in ER-Positive Breast Cancer
Liu Y, Zhang N, Zhang H, Wang L, Duan Y, Wang X, Chen T, Liang Y, Li Y, Song X, Li C, Han D, Chen B, Zhao W, Yang Q
Drug Design, Development and Therapy 2020, 14:3535-3545
Published Date: 26 August 2020
Bone-Targeting Liposome-Encapsulated Salvianic Acid A Improves Nonunion Healing Through the Regulation of HDAC3-Mediated Endochondral Ossification
Zhou L, Wu H, Gao X, Zheng X, Chen H, Li H, Peng J, Liang W, Wang W, Qiu Z, Udduttula A, Wu K, Li L, Liu Y, Liu Y
Drug Design, Development and Therapy 2020, 14:3519-3533
Published Date: 26 August 2020
Application of Intravenous Lidocaine in Obese Patients Undergoing Painless Colonoscopy: A Prospective, Randomized, Double-Blind, Controlled Study
Li X, Lv X, Jiang Z, Nie X, Wang X, Li T, Zhang L, Liu S
Drug Design, Development and Therapy 2020, 14:3509-3518
Published Date: 27 August 2020
Exosomes-Coated miR-34a Displays Potent Antitumor Activity in Pancreatic Cancer Both in vitro and in vivo
Zuo L, Tao H, Xu H, Li C, Qiao G, Guo M, Cao S, Liu M, Lin X
Drug Design, Development and Therapy 2020, 14:3495-3507
Published Date: 25 August 2020
Effectiveness of Metoprolol in Improving Cardiac and Motor Functions in Patients with Chronic Heart Failure: A Prospective Study
Cheng X, Zhu M, Liu Q, Feng Z, Meng Y
Drug Design, Development and Therapy 2020, 14:3485-3494
Published Date: 25 August 2020
Video Education Reduces Pain and Anxiety Levels in Cancer Patients Who First Use Fentanyl Transdermal Patch: A Randomized Controlled Trial
Ye Z, Chen J, Zhang Y, Hu X, Xuan Z, Yang S, Mao X, Rao Y
Drug Design, Development and Therapy 2020, 14:3477-3483
Published Date: 25 August 2020
Analysis of the Doxorubicin and Doxorubicinol in the Plasma of Breast Cancer Patients for Monitoring the Toxicity of Doxorubicin
Harahap Y, Ardiningsih P, Corintias Winarti A, Purwanto DJ
Drug Design, Development and Therapy 2020, 14:3469-3475
Published Date: 25 August 2020
Transarterial Chemoembolization Combined with Sorafenib in Patients with BCLC Stage C Hepatocellular Carcinoma
Liu KC, Hao YH, Lv WF, Jia WD, Ji CS, Zhou CZ, Cheng DL, Xu SB, Gao ZG, Su MX, Shi CS
Drug Design, Development and Therapy 2020, 14:3461-3468
Published Date: 25 August 2020
Levonorgestrel Ameliorates Adenomyosis via lncRNA H19/miR-17/TLR4 Pathway
Liang N, Zhang W, Wang H, Shi W, Wang L, Ma L
Drug Design, Development and Therapy 2020, 14:3449-3460
Published Date: 24 August 2020
Sarsasapogenin Suppresses RANKL-Induced Osteoclastogenesis in vitro and Prevents Lipopolysaccharide-Induced Bone Loss in vivo
Peng J, Zhao K, Zhu J, Wang Y, Sun P, Yang Q, Zhang T, Han W, Hu W, Yang W, Ruan J, Qian Y
Drug Design, Development and Therapy 2020, 14:3435-3447
Published Date: 24 August 2020
A Single Large Dose of Vitamin D Could be Used as a Means of Coronavirus Disease 2019 Prevention and Treatment
Liu G, Hong T, Yang J
Drug Design, Development and Therapy 2020, 14:3429-3434
Published Date: 21 August 2020
Carboplatin Inhibits the Progression of Retinoblastoma Through IncRNA XIST/miR-200a-3p/NRP1 Axis
Zhao H, Wan J, Zhu Y
Drug Design, Development and Therapy 2020, 14:3417-3427
Published Date: 21 August 2020
Efficacy of Sub-Tenon Micro-Perfusion of Cyclophosphamide in Rabbits with Severe Ocular Inflammation
Zhao L, Peng M, Lin W, Tan Q, Khan MA, Lin D
Drug Design, Development and Therapy 2020, 14:3407-3416
Published Date: 20 August 2020
Galangin Improved Non-Alcoholic Fatty Liver Disease in Mice by Promoting Autophagy
Zhang X, Deng Y, Xiang J, Liu H, Zhang J, Liao J, Chen K, Liu B, Liu J, Pu Y
Drug Design, Development and Therapy 2020, 14:3393-3405
Published Date: 19 August 2020
Cyanidin-3-O-Glucoside Improves Colonic Motility During Severe Acute Pancreatitis by Inhibiting the H2S-Regulated AMPK/mTOR Pathway
Lian W, Chen W
Drug Design, Development and Therapy 2020, 14:3385-3391
Published Date: 19 August 2020
Protective Effects of Rocuronium Bromide on Ischemia-Reperfusion Injury in Skeletal Muscle Induced by Tourniquet in Patients Undergoing Elective Unilateral Total Knee Arthroplasty: A Prospective, Double Blind, Randomized, Controlled Study
Chen H, Wei JQ, Wang YW, Zhou KP, He Y, Liu H, Zhang YY
Drug Design, Development and Therapy 2020, 14:3373-3384
Published Date: 18 August 2020
Cinnamaldehyde Treatment of Prostate Cancer-Associated Fibroblasts Prevents Their Inhibitory Effect on T Cells Through Toll-Like Receptor 4
Mei J, Ma J, Xu Y, Wang Y, Hu M, Ma F, Qin Z, Xue R, Tao N
Drug Design, Development and Therapy 2020, 14:3363-3372
Published Date: 18 August 2020
Cannabis Extract CT-921 Has a High Efficacy–Adverse Effect Profile in a Neuropathic Pain Model
Rouhollahi E, MacLeod BA, Barr AM, Puil E
Drug Design, Development and Therapy 2020, 14:3351-3361
Published Date: 17 August 2020
New Benzofuran N-Acylhydrazone Reduces Cardiovascular Dysfunction in Obese Rats by Blocking TNF-Alpha Synthesis
Costa GC, Montagnoli TL, Da Silva JS, Alencar AKN, Reina Gamba LE, Alves BEO, Silva MMC, Trachez MM, Nascimento JHM, Pimentel-Coelho PM, Mendez-Otero R, Lima LM, Barreiro EJ, Sudo RT, Zapata-Sudo G
Drug Design, Development and Therapy 2020, 14:3337-3350
Published Date: 17 August 2020
Beneficial Effect of Genistein on Diabetes-Induced Brain Damage in the ob/ob Mouse Model
Li R, Ding XW, Geetha T, Al-Nakkash L, Broderick TL, Babu JR
Drug Design, Development and Therapy 2020, 14:3325-3336
Published Date: 17 August 2020
Assessment of a New Ginsenoside Rh2 Nanoniosomal Formulation for Enhanced Antitumor Efficacy on Prostate Cancer: An in vitro Study
Zare-Zardini H, Alemi A, Taheri-Kafrani A, Hosseini SA, Soltaninejad H, Hamidieh AA, Haghi Karamallah M, Farrokhifar M, Farrokhifar M
Drug Design, Development and Therapy 2020, 14:3315-3324
Published Date: 13 August 2020
Dual Targeting of Cell Growth and Phagocytosis by Erianin for Human Colorectal Cancer
Sun Y, Li G, Zhou Q, Shao D, Lv J, Zhou J
Drug Design, Development and Therapy 2020, 14:3301-3313
Published Date: 12 August 2020
Atorvastatin Combined with Low-Dose Dexamethasone Treatment Protects Endothelial Function Impaired by Chronic Subdural Hematoma via the Transcription Factor KLF-2
Fan Y, Wang D, Rao C, Li Y, Rong H, Wang Z, Zhang J
Drug Design, Development and Therapy 2020, 14:3291-3299
Published Date: 12 August 2020
Potential of Nanoparticles as Permeation Enhancers and Targeted Delivery Options for Skin: Advantages and Disadvantages
Ghasemiyeh P, Mohammadi-Samani S
Drug Design, Development and Therapy 2020, 14:3271-3289
Published Date: 12 August 2020
Effect of Intravenous Injection of Vitamin C on Postoperative Pulmonary Complications in Patients Undergoing Cardiac Surgery: A Double-Blind, Randomized Trial
Wang D, Wang M, Zhang H, Zhu H, Zhang N, Liu J
Drug Design, Development and Therapy 2020, 14:3263-3270
Published Date: 11 August 2020
Therapeutic Drug Monitoring of Rivastigmine and Donepezil Under Consideration of CYP2D6 Genotype-Dependent Metabolism of Donepezil
Ortner M, Stange M, Schneider H, Schröder C, Buerger K, Müller C, Müller-Sarnowski F, Diehl-Schmid J, Förstl H, Grimmer T, Steimer W
Drug Design, Development and Therapy 2020, 14:3251-3262
Published Date: 11 August 2020
Potential Impact of the Multi-Target Drug Approach in the Treatment of Some Complex Diseases
Makhoba XH, Viegas Jr C, Mosa RA, Viegas FPD, Pooe OJ
Drug Design, Development and Therapy 2020, 14:3235-3249
Published Date: 11 August 2020
Hirudin Protects Against Kidney Damage in Streptozotocin-Induced Diabetic Nephropathy Rats by Inhibiting Inflammation via P38 MAPK/NF-κB Pathway
Han J, Pang X, Zhang Y, Peng Z, Shi X, Xing Y
Drug Design, Development and Therapy 2020, 14:3223-3234
Published Date: 7 August 2020
A Review on Remdesivir: A Possible Promising Agent for the Treatment of COVID-19
Hashemian SM, Farhadi T, Velayati AA
Drug Design, Development and Therapy 2020, 14:3215-3222
Published Date: 6 August 2020
Suppression of c-Met-Overexpressing Tumors by a Novel c-Met/CD3 Bispecific Antibody
Huang L, Xie K, Li H, Wang R, Xu X, Chen K, Gu H, Fang J
Drug Design, Development and Therapy 2020, 14:3201-3214
Published Date: 7 August 2020
First-in-Human Evaluation of the Safety, Tolerability, and Pharmacokinetics of a Neuroprotective Poly (ADP‐ribose) Polymerase‐1 Inhibitor, JPI-289, in Healthy Volunteers
Han S, Kim YH, Choi HY, Soh DJ, Kim J, Nam J, Kim JW, Bae KS, Lim HS
Drug Design, Development and Therapy 2020, 14:3189-3199
Published Date: 5 August 2020
Melatonin Plays a Protective Role by Regulating miR-26a-5p-NRSF and JAK2-STAT3 Pathway to Improve Autophagy, Inflammation and Oxidative Stress of Cerebral Ischemia-Reperfusion Injury
Yang B, Zang LE, Cui JW, Zhang MY, Ma X, Wei LL
Drug Design, Development and Therapy 2020, 14:3177-3188
Published Date: 6 August 2020
The Protective Effects of Juglanin in Cerebral Ischemia Reduce Blood–Brain Barrier Permeability via Inhibition of VEGF/VEGFR2 Signaling
Liu J, Chen L, Zhang X, Pan L, Jiang L
Drug Design, Development and Therapy 2020, 14:3165-3175
Published Date: 5 August 2020
Curcumin Protects Against Radiotherapy-Induced Oxidative Injury to the Skin
Shabeeb D, Musa AE, Abd Ali HS, Najafi M
Drug Design, Development and Therapy 2020, 14:3159-3163
Published Date: 5 August 2020
Exosomes Derived from MicroRNA-146a-5p-Enriched Bone Marrow Mesenchymal Stem Cells Alleviate Intracerebral Hemorrhage by Inhibiting Neuronal Apoptosis and Microglial M1 Polarization
Duan S, Wang F, Cao J, Wang C
Drug Design, Development and Therapy 2020, 14:3143-3158
Published Date: 5 August 2020
Bioequivalence Study of Amitriptyline Hydrochloride Tablets in Healthy Chinese Volunteers Under Fasting and Fed Conditions
Zhai Y, Wu L, Zheng Y, Wu M, Huang Y, Huang Q, Shentu J, Zhao Q, Liu J
Drug Design, Development and Therapy 2020, 14:3131-3142
Published Date: 4 August 2020
Novel HDAC/Tubulin Dual Inhibitor: Design, Synthesis and Docking Studies of α-Phthalimido-Chalcone Hybrids as Potential Anticancer Agents with Apoptosis-Inducing Activity
Mourad AAE, Mourad MAE, Jones PG
Drug Design, Development and Therapy 2020, 14:3111-3130
Published Date: 3 August 2020
The PPARγ Agonist Rosiglitazone Enhances the Radiosensitivity of Human Pancreatic Cancer Cells
Wang Z, Shen W, Li X, Feng Y, Qian K, Wang G, Gao Y, Xu X, Zhang S, Yue L, Cao J
Drug Design, Development and Therapy 2020, 14:3099-3110
Published Date: 31 July 2020
Nano-Graphene Oxide-supported APTES-Spermine, as Gene Delivery System, for Transfection of pEGFP-p53 into Breast Cancer Cell Lines
Mirzaie V, Ansari M, Nematollahi-Mahani SN, Moballegh Nasery M, Karimi B, Eslaminejad T, Pourshojaei Y
Drug Design, Development and Therapy 2020, 14:3087-3097
Published Date: 30 July 2020
Antibacterial of Dibenzo-p-Dioxi-2,8-Dicarboxylic Acid Against Pathogenic Oral Bacteria E. faecalis ATCC 29212 Peptide Pheromones: Quorum Sensing of in vitro and in silico Study
Kurnia D, Rachmawati P, Satari MH
Drug Design, Development and Therapy 2020, 14:3079-3086
Published Date: 30 July 2020
In vivo Screening of Natural Products Against Angiogenesis and Mechanisms of Anti-Angiogenic Activity of Deoxysappanone B 7,4ʹ-Dimethyl Ether
Chen K, Fan Y, Gu J, Han Z, Zeng H, Mao C, Wang C
Drug Design, Development and Therapy 2020, 14:3069-3078
Published Date: 30 July 2020
Synergistic Effect of Tangeretin and Atorvastatin for Colon Cancer Combination Therapy: Targeted Delivery of These Dual Drugs Using RGD Peptide Decorated Nanocarriers
Bao H, Zheng N, Li Z, Zhi Y
Drug Design, Development and Therapy 2020, 14:3057-3068
Published Date: 29 July 2020
The Climate is Changing for Metered-Dose Inhalers and Action is Needed
Pritchard JN
Drug Design, Development and Therapy 2020, 14:3043-3055
Published Date: 29 July 2020
Botulinum Toxin Type A Possibly Affects Cav3.2 Calcium Channel Subunit in Rats with Spinal Cord Injury-Induced Muscle Spasticity
Ma K, Zhu D, Zhang C, Lv L
Drug Design, Development and Therapy 2020, 14:3029-3041
Published Date: 28 July 2020
Chrysin Attenuates the NLRP3 Inflammasome Cascade to Reduce Synovitis and Pain in KOA Rats
Liao T, Ding L, Wu P, Zhang L, Li X, Xu B, Zhang H, Ma Z, Xiao Y, Wang P
Drug Design, Development and Therapy 2020, 14:3015-3027
Published Date: 28 July 2020
Antiviral Agent Therapy Optimization in Special Populations of COVID-19 Patients
Li L, Wang X, Wang R, Hu Y, Jiang S, Lu X
Drug Design, Development and Therapy 2020, 14:3001-3013
Published Date: 28 July 2020
Cordycepin Inhibits Human Gestational Choriocarcinoma Cell Growth by Disrupting Centrosome Homeostasis
Wang CY, Tsai SW, Chien HH, Chen TY, Sheu SY, So EC, Huang BM
Drug Design, Development and Therapy 2020, 14:2987-3000
Published Date: 27 July 2020
Potential Allylpyrocatechol Derivatives as Antibacterial Agent Against Oral Pathogen of S. sanguinis ATCC 10,556 and as Inhibitor of MurA Enzymes: in vitro and in silico Study
Kurnia D, Hutabarat GS, Windaryanti D, Herlina T, Herdiyati Y, Satari MH
Drug Design, Development and Therapy 2020, 14:2977-2985
Published Date: 27 July 2020
Soluplus-Mediated Diosgenin Amorphous Solid Dispersion with High Solubility and High Stability: Development, Characterization and Oral Bioavailability
Liu P, Zhou J, Chang J, Liu X, Xue H, Wang R, Li Z, Li C, Wang J, Liu C
Drug Design, Development and Therapy 2020, 14:2959-2975
Published Date: 27 July 2020
Enhancement of Antitumor Efficacy of Paclitaxel-Loaded PEGylated Liposomes by N,N-Dimethyl Tertiary Amino Moiety in Pancreatic Cancer
Chen Y, Wang L, Luo S, Hu J, Huang X, Li PW, Zhang Y, Wu C, Tian BL
Drug Design, Development and Therapy 2020, 14:2945-2957
Published Date: 23 July 2020
The Effects of Dexmedetomidine and Ketamine on Oxidative Injuries and Histological Changes Following Blunt Chest Trauma
Kartal S, Kip G, Küçük A, Aşçı SS, Erdem Ö, Arslan M, Kavutçu M
Drug Design, Development and Therapy 2020, 14:2937-2943
Published Date: 23 July 2020
Triptolide Inhibits the Proliferation of HaCaT Cells Induced by IL22 via Upregulating miR-181b-5p
He Q, Zhang B, Hu F, Long J, Shi Q, Pi X, Chen H, Li J
Drug Design, Development and Therapy 2020, 14:2927-2935
Published Date: 22 July 2020
Film-Forming Sprays for Topical Drug Delivery
Umar AK, Butarbutar M, Sriwidodo S, Wathoni N
Drug Design, Development and Therapy 2020, 14:2909-2925
Published Date: 22 July 2020
Loratadine Alleviates Advanced Glycation End Product-Induced Activation of NLRP3 Inflammasome in Human Chondrocytes
Gao F, Zhang S
Drug Design, Development and Therapy 2020, 14:2899-2908
Published Date: 21 July 2020
The Safety and Efficacy of Ultrasound-Guided Bilateral Dual Transversus Abdominis Plane (BD-TAP) Block in ERAS Program of Laparoscopic Hepatectomy: A Prospective, Randomized, Controlled, Blinded, Clinical Study
Zhang J, Liu T, Zhou H, Fei Y, Yu X
Drug Design, Development and Therapy 2020, 14:2889-2898
Published Date: 21 July 2020
Pharmacokinetic Analysis of Huangqi Guizhi Wuwu Decoction on Blood and Brain Tissue in Rats with Normal and Cerebral Ischemia-Reperfusion Injury by Microdialysis with HPLC-MS/MS
Zheng HZ, Shen X, He YY, Yan XL, Wang SX, Yu AM, Wang LS
Drug Design, Development and Therapy 2020, 14:2877-2888
Published Date: 21 July 2020
Neuroprotective Effect of Mesenchymal Stromal Cell-Derived Extracellular Vesicles Against Cerebral Ischemia-Reperfusion-Induced Neural Functional Injury: A Pivotal Role for AMPK and JAK2/STAT3/NF-κB Signaling Pathway Modulation
Han M, Cao Y, Xue H, Chu X, Li T, Xin D, Yuan L, Ke H, Li G, Wang Z
Drug Design, Development and Therapy 2020, 14:2865-2876
Published Date: 20 July 2020
Tanshinone IIA Ameliorates Progression of CAD Through Regulating Cardiac H9c2 Cells Proliferation and Apoptosis by miR-133a-3p/EGFR Axis
Xu H, Li H, Zhu P, Liu Y, Zhou M, Chen A
Drug Design, Development and Therapy 2020, 14:2853-2863
Published Date: 20 July 2020
The Anti-Inflammatory Effect of Different Doses of Aliskiren in Rat Models of Inflammation
Aziz TA, Kareem AA, Othman HH, Ahmed ZA
Drug Design, Development and Therapy 2020, 14:2841-2851
Published Date: 20 July 2020
A critical review of the United States regulatory pathways for determining the equivalence of efficacy between CT-P13 and original infliximab (Remicade®)
Kim S, Kim S, Lee H
Drug Design, Development and Therapy 2020, 14:2831-2840
Published Date: 17 July 2020
Lentinan Inhibits AGE-Induced Inflammation and the Expression of Matrix-Degrading Enzymes in Human Chondrocytes
Zhang Z, Zha Z, Zhao Z, Liu W, Li W
Drug Design, Development and Therapy 2020, 14:2819-2829
Published Date: 17 July 2020
Cordycepin Alleviates Anterior Cruciate Ligament Transection (ACLT)-Induced Knee Osteoarthritis Through Regulating TGF-β Activity and Autophagy
Tao XM, Liu PF, Gu HY, Lian DB, Gao L, Tao WW, Yan D, Zhao B
Drug Design, Development and Therapy 2020, 14:2809-2817
Published Date: 17 July 2020
A Synthetic Peptide 2Abz23S29 Reduces Bacterial Titer and Induces Pro-Inflammatory Cytokines in a Murine Model of Urinary Tract Infection
Moazzezy N, Asadi Karam MR, Rafati S, Bouzari S, Oloomi M
Drug Design, Development and Therapy 2020, 14:2797-2807
Published Date: 17 July 2020
Does an Earlier or Late Intravenous Injection of Ondansetron Affect the Dose of Phenylephrine Needed to Prevent Spinal-Anesthesia Induced Hypotension in Cesarean Sections?
Qian J, Liu L, Zheng X, Xiao F
Drug Design, Development and Therapy 2020, 14:2789-2795
Published Date: 16 July 2020
Tanshinone IIA Promotes Axonal Regeneration in Rats with Focal Cerebral Ischemia Through the Inhibition of Nogo-A/NgR1/RhoA/ROCKII/MLC Signaling
Wang J, Ni G, Liu Y, Han Y, Jia L, Wang Y
Drug Design, Development and Therapy 2020, 14:2775-2787
Published Date: 15 July 2020
Danoprevir for the Treatment of Hepatitis C Virus Infection: Design, Development, and Place in Therapy
Miao M, Jing X, De Clercq E, Li G
Drug Design, Development and Therapy 2020, 14:2759-2774
Published Date: 14 July 2020
Promising Swellable Floating Bupropion Tablets: Formulation, in vitro/in vivo Evaluation and Comparative Pharmacokinetic Study in Human Volunteers
Teaima M, Abdel Hamid MM, Shoman NA, Jasti BR, El-Nabarawi MA
Drug Design, Development and Therapy 2020, 14:2741-2757
Published Date: 14 July 2020
Network Pharmacology-Based Prediction and Verification of the Active Ingredients and Potential Targets of Zuojinwan for Treating Colorectal Cancer
Huang S, Zhang Z, Li W, Kong F, Yi P, Huang J, Mao D, Peng W, Zhang S
Drug Design, Development and Therapy 2020, 14:2725-2740
Published Date: 14 July 2020
The Regulating Mechanism of Chrysophanol on Protein Level of CaM-CaMKIV to Protect PC12 Cells Against Aβ25-35-Induced Damage
Ye T, Gao HW, Xuan WT, Ye S, Zhou P, Li XQ, Wang Y, Song H, Liu YY, Cai B
Drug Design, Development and Therapy 2020, 14:2715-2723
Published Date: 13 July 2020
Clostridium histolyticum (AA4500) for the Treatment of Adhesive Capsulitis of the Shoulder: A Randomised Double-Blind, Placebo-Controlled Study for the Safety and Efficacy of Collagenase – Single Site Report
Fitzpatrick J, Richardson C, Klaber I, Richardson MD
Drug Design, Development and Therapy 2020, 14:2707-2713
Published Date: 10 July 2020
Ulinastatin Promotes Regeneration of Peripheral Nerves After Sciatic Nerve Injury by Targeting let-7 microRNAs and Enhancing NGF Expression
Zhang J, Zhang Y, Chen L, Rao Z, Sun Y
Drug Design, Development and Therapy 2020, 14:2695-2705
Published Date: 9 July 2020
Ribbon Synapses and Hearing Impairment in Mice After in utero Sevoflurane Exposure
Yuan X, Liu H, Li Y, Li W, Yu H, Shen X
Drug Design, Development and Therapy 2020, 14:2685-2693
Published Date: 8 July 2020
Anti-Breast Cancer Effect of 2-Dodecyl-6-Methoxycyclohexa-2,5-Diene-1,4-Dione in vivo and in vitro Through MAPK Signaling Pathway
Zhou X, Wu X, Qin L, Lu S, Zhang H, Wei J, Chen L, Jiang L, Wu Y, Chen C, Huang R
Drug Design, Development and Therapy 2020, 14:2667-2684
Published Date: 7 July 2020
N-Acetyl-l-Leucine-Polyethyleneimine-Mediated Delivery of CpG Oligodeoxynucleotides 2006 Inhibits RAW264.7 Cell Osteoclastogenesis
Wang H, Yu W, Li H, Zheng Y, Chen Z, Lin H, Shen Y
Drug Design, Development and Therapy 2020, 14:2657-2665
Published Date: 7 July 2020
Baicalin Protects Human OA Chondrocytes Against IL-1β-Induced Apoptosis and ECM Degradation by Activating Autophagy via MiR-766-3p/AIFM1 Axis
Li Z, Cheng J, Liu J
Drug Design, Development and Therapy 2020, 14:2645-2655
Published Date: 7 July 2020
Evaluation of Bioequivalency and Pharmacokinetic Parameters for Two Formulations of Glimepiride 1-mg in Chinese Subjects
Ju G, Yan K, Xu Y, Chen S, Zheng Z, Qiu W
Drug Design, Development and Therapy 2020, 14:2637-2644
Published Date: 6 July 2020
Volanesorsen in the Treatment of Familial Chylomicronemia Syndrome or Hypertriglyceridaemia: Design, Development and Place in Therapy
Esan O, Wierzbicki AS
Drug Design, Development and Therapy 2020, 14:2623-2636
Published Date: 6 July 2020
The Expression and Therapeutic Potential of Checkpoint Kinase 2 in Laryngeal Squamous Cell Carcinoma
Tian Y, Wang Y, Xu S, Guan C, Zhang Q, Li W
Drug Design, Development and Therapy 2020, 14:2613-2622
Published Date: 6 July 2020
Plasmapheresis, Anti-ACE2 and Anti-FcγRII Monoclonal Antibodies: A Possible Treatment for Severe Cases of COVID-19
Sedokani A, Feizollahzadeh S
Drug Design, Development and Therapy 2020, 14:2607-2611
Published Date: 6 July 2020
Effects of Dexmedetomidine on the Pharmacokinetics of Dezocine, Midazolam and Its Metabolite 1-Hydroxymidazolam in Beagles by UPLC-MS/MS
Zhou W, Li S, Zhao T, Li L, Xing W, Qiu X, Zhang W
Drug Design, Development and Therapy 2020, 14:2595-2605
Published Date: 3 July 2020
Structural Insight into the Mechanism of 4-Aminoquinolines Selectivity for the alpha2A-Adrenoceptor
Li Z, Li J, Liu L, Deng W, Liu Q, Liu R, Zhang W, He Z, Fan L, Yang Y, Duan Y, Hou H, Wang X, Yang Z, Wang X, Chen S, Wang Y, Huang N, Chen J
Drug Design, Development and Therapy 2020, 14:2585-2594
Published Date: 3 July 2020
Melatonin Alleviates Neuronal Damage After Intracerebral Hemorrhage in Hyperglycemic Rats
Liang F, Wang J, Zhu X, Wang Z, Zheng J, Sun Z, Xu S, Zhang J, Zhou J, Shi L
Drug Design, Development and Therapy 2020, 14:2573-2584
Published Date: 2 July 2020
Effects of Calcium and Annatto Tocotrienol Supplementation on Bone Loss Induced by Pantoprazole in Male Rats
Chin KY, Thong BKS, Kamalulloh RF, Mohamad NV, Wong SK, Mohd Arlamsyah A, Triliana R, Soelaiman IN
Drug Design, Development and Therapy 2020, 14:2561-2572
Published Date: 2 July 2020
Impact of Administration Time and Kv7 Subchannels on the Cardioprotective Efficacy of Kv7 Channel Inhibition
Hansen J, Johnsen J, Nielsen JM, Sørensen CB, Elkjær CC, Jespersen NR, Bøtker HE
Drug Design, Development and Therapy 2020, 14:2549-2560
Published Date: 2 July 2020
Thymol Isolated from Thymus vulgaris L. Inhibits Colorectal Cancer Cell Growth and Metastasis by Suppressing the Wnt/β-Catenin Pathway
Zeng Q, Che Y, Zhang Y, Chen M, Guo Q, Zhang W
Drug Design, Development and Therapy 2020, 14:2535-2547
Published Date: 1 July 2020
Synthesis and Biological Evaluations of Monocarbonyl Curcumin Inspired Pyrazole Analogues as Potential Anti-Colon Cancer Agent
Min Z, Zhu Y, Hong X, Yu Z, Ye M, Yuan Q, Hu X
Drug Design, Development and Therapy 2020, 14:2517-2534
Published Date: 29 June 2020
Attenuation of Myocardial Fibrosis with Curcumin Is Mediated by Modulating Expression of Angiotensin II AT1/AT2 Receptors and ACE2 in Rats [Corrigendum]
Pang X, Zhang L, Bai F, Wang N, Garner RE, McKallip R, Zhao Z
Drug Design, Development and Therapy 2020, 14:2515-2516
Published Date: 26 June 2020
Management of Pediatric Systemic Lupus Erythematosus: Focus on Belimumab
Guzman M, Hui-Yuen JS
Drug Design, Development and Therapy 2020, 14:2503-2513
Published Date: 25 June 2020
Remogliflozin Etabonate in the Treatment of Type 2 Diabetes: Design, Development, and Place in Therapy
Mohan V, Mithal A, Joshi SR, Aravind SR, Chowdhury S
Drug Design, Development and Therapy 2020, 14:2487-2501
Published Date: 24 June 2020
Are Laboratory Parameter (Biomarker) Values Similar to the Healthy Volunteer Reference Range in Individuals with Diabetes
Brott DA, Goodman MJ, Hermann RP, Anderson I, Kiazand A
Drug Design, Development and Therapy 2020, 14:2473-2486
Published Date: 24 June 2020
Lycopene Inhibits Epithelial–Mesenchymal Transition and Promotes Apoptosis in Oral Cancer via PI3K/AKT/m-TOR Signal Pathway
Wang R, Lu X, Yu R
Drug Design, Development and Therapy 2020, 14:2461-2471
Published Date: 24 June 2020
Berberine Attenuates Arterial Plaque Formation in Atherosclerotic Rats with Damp-Heat Syndrome via Regulating Autophagy
Ke X, Huang Y, Li L, Xin F, Xu L, Zhang Y, Zeng Z, Lin F, Song Y
Drug Design, Development and Therapy 2020, 14:2449-2460
Published Date: 23 June 2020
Artificial Neural Network (ANN) Approach to Predict an Optimized pH-Dependent Mesalamine Matrix Tablet
Khan AM, Hanif M, Bukhari NI, Shamim R, Rasool F, Rasul S, Shafique S
Drug Design, Development and Therapy 2020, 14:2435-2448
Published Date: 22 June 2020
Evaluation of the Efficacy of Neoadjuvant Chemotherapy for Breast Cancer
Wang H, Mao X
Drug Design, Development and Therapy 2020, 14:2423-2433
Published Date: 18 June 2020
Aprepitant Sensitizes Acute Myeloid Leukemia Cells to the Cytotoxic Effects of Cytosine Arabinoside in vitro and in vivo
Wu H, Cheng X, Huang F, Shao G, Meng Y, Wang L, Wang T, Jia X, Yang T, Wang X, Fu C
Drug Design, Development and Therapy 2020, 14:2413-2422
Published Date: 18 June 2020
Sugar Codes Conjugated Alginate: An Innovative Platform to Make a Strategic Breakthrough in Simultaneous Prophylaxis of GERD and Helicobacter pylori Infection
Moayedi S, Yadegar A, Balalaie S, Yarmohammadi M, Zali MR, Suzuki H, Fricker G, Haririan I
Drug Design, Development and Therapy 2020, 14:2405-2412
Published Date: 17 June 2020
Sinomenine Attenuates Acetaminophen-Induced Acute Liver Injury by Decreasing Oxidative Stress and Inflammatory Response via Regulating TGF-β/Smad Pathway in vitro and in vivo
Chen H, Wang Y, Jiao FZ, Yang F, Li X, Wang LW
Drug Design, Development and Therapy 2020, 14:2393-2403
Published Date: 17 June 2020
Metformin Decreases Insulin Resistance in Type 1 Diabetes Through Regulating p53 and RAP2A in vitro and in vivo
Ren GF, Xiao LL, Ma XJ, Yan YS, Jiao PF
Drug Design, Development and Therapy 2020, 14:2381-2392
Published Date: 17 June 2020
Activation of GPR40 Suppresses AGE-Induced Reduction of Type II Collagen and Aggrecan in Human SW1353 Chondrocytes
Gu J, Lin H, Zhang Y, Xu T, Wang T, Xue X, Zhang W, Liu H
Drug Design, Development and Therapy 2020, 14:2371-2379
Published Date: 15 June 2020
A Gastric Cancer Peptide GX1-Modified Nano-Lipid Carriers Encapsulating Paclitaxel: Design and Evaluation of Anti-Tumor Activity
Jian Y, Zhao M, Cao J, Fan T, Bu W, Yang Y, Li W, Zhang W, Qiao Y, Wang J, Wen A
Drug Design, Development and Therapy 2020, 14:2355-2370
Published Date: 12 June 2020
Suppression of Cisplatin-Induced Hepatic Injury in Rats Through Alarmin High-Mobility Group Box-1 Pathway by Ganoderma lucidum: Theoretical and Experimental Study
Hassan HM, Al-Wahaibi LH, Elmorsy MA, Mahran YF
Drug Design, Development and Therapy 2020, 14:2335-2353
Published Date: 11 June 2020
In vitro and in vivo Anti-Tumor Effects of Pan-HER Inhibitor Varlitinib on Cholangiocarcinoma Cell Lines
Dokduang H, Jamnongkarn W, Promraksa B, Suksawat M, Padthaisong S, Thanee M, Phetcharaburanin J, Namwat N, Sangkhamanon S, Titapun A, Khuntikeo N, Klanrit P, Loilome W
Drug Design, Development and Therapy 2020, 14:2319-2334
Published Date: 11 June 2020
Scalable in silico Simulation of Transdermal Drug Permeability: Application of BIOiSIM Platform
Maharao N, Antontsev V, Hou H, Walsh J, Varshney J
Drug Design, Development and Therapy 2020, 14:2307-2317
Published Date: 11 June 2020
Nimodipine Improves Cognitive Impairment After Subarachnoid Hemorrhage in Rats Through IncRNA NEAT1/miR-27a/MAPT Axis
Li JW, Ren SH, Ren JR, Zhen ZG, Li LR, Hao XD, Ji HM
Drug Design, Development and Therapy 2020, 14:2295-2306
Published Date: 10 June 2020
The Use of Amikacin Liposome Inhalation Suspension (Arikayce) in the Treatment of Refractory Nontuberculous Mycobacterial Lung Disease in Adults
Khan O, Chaudary N
Drug Design, Development and Therapy 2020, 14:2287-2294
Published Date: 10 June 2020
Astaxanthin in Liver Health and Disease: A Potential Therapeutic Agent
Li J, Guo C, Wu J
Drug Design, Development and Therapy 2020, 14:2275-2285
Published Date: 9 June 2020
Combination Therapy of Lung Cancer Using Layer-by-Layer Cisplatin Prodrug and Curcumin Co-Encapsulated Nanomedicine
Hong Y, Che S, Hui B, Wang X, Zhang X, Ma H
Drug Design, Development and Therapy 2020, 14:2263-2274
Published Date: 9 June 2020
Combination Chemotherapy of Lung Cancer – Co-Delivery of Docetaxel Prodrug and Cisplatin Using Aptamer-Decorated Lipid–Polymer Hybrid Nanoparticles
Wu R, Zhang Z, Wang B, Chen G, Zhang Y, Deng H, Tang Z, Mao J, Wang L
Drug Design, Development and Therapy 2020, 14:2249-2261
Published Date: 9 June 2020
Parenteral Sustained Release Lipid Phase-Transition System of Ziprasidone: Fabrication and Evaluation for Schizophrenia Therapy
Khan UA, Parveen U, Hasan N, Ahmed MZ, Saad S, Ahmad FJ, Jain GK
Drug Design, Development and Therapy 2020, 14:2237-2247
Published Date: 9 June 2020
Activation of Cholinergic Anti-Inflammatory Pathway in Peripheral Immune Cells Involved in Therapeutic Actions of α-Mangostin on Collagen-Induced Arthritis in Rats [Corrigendum]
Yin Q, Wu Y, Pan S, Wang D, Tao M, Pei W, Zuo J
Drug Design, Development and Therapy 2020, 14:2235-2236
Published Date: 9 June 2020
Treatment with a PPAR-γ Agonist Protects Against Hyperuricemic Nephropathy in a Rat Model
Wang X, Deng J, Xiong C, Chen H, Zhou Q, Xia Y, Shao X, Zou H
Drug Design, Development and Therapy 2020, 14:2221-2233
Published Date: 8 June 2020
Gastro-Protective Effects of Calycosin Against Precancerous Lesions of Gastric Carcinoma in Rats
Li D, Zhao L, Li Y, Kang X, Zhang S
Drug Design, Development and Therapy 2020, 14:2207-2219
Published Date: 9 June 2020
Effects of Voriconazole on the Pharmacokinetics of Vonoprazan in Rats
Shen J, Wang B, Wang S, Chen F, Meng D, Jiang H, Zhou Y, Geng P, Zhou Q, Liu B
Drug Design, Development and Therapy 2020, 14:2199-2206
Published Date: 4 June 2020
Development of 13-Cys-BBR as an Agent Having Dual Action of Anti-Thrombosis and Anti-Inflammation
Li G, Wang T, Zhang X, Zhao S, Wang Y, Wu J, Peng S, Zhao M
Drug Design, Development and Therapy 2020, 14:2187-2197
Published Date: 3 June 2020
Doublet vs Single-Agent Maintenance Therapy in the Treatment of Non-Small-Cell Lung Cancer: A Meta-Analysis
Qi J, Guo X, Li A
Drug Design, Development and Therapy 2020, 14:2179-2185
Published Date: 3 June 2020
Comparative Cholinesterase, α-Glucosidase Inhibitory, Antioxidant, Molecular Docking, and Kinetic Studies on Potent Succinimide Derivatives
Ahmad A, Ullah F, Sadiq A, Ayaz M, Saeed Jan M, Shahid M, Wadood A, Mahmood F, Rashid U, Ullah R, Sahibzada MUK, Alqahtani AS, Mahmood HM
Drug Design, Development and Therapy 2020, 14:2165-2178
Published Date: 3 June 2020
Characteristics of COVID-19 Clinical Trials in China Based on the Registration Data on ChiCTR and ClinicalTrials.gov
Huang J, He Y, Su Q, Yang J
Drug Design, Development and Therapy 2020, 14:2159-2164
Published Date: 29 May 2020
Analysis of Renal and Cardiac Outcomes in Male Participants in the Fabry Outcome Survey Starting Agalsidase Alfa Enzyme Replacement Therapy Before and After 18 Years of Age
Parini R, Pintos-Morell G, Hennermann JB, Hsu TR, Karabul N, Kalampoki V, Gurevich A, Ramaswami U
Drug Design, Development and Therapy 2020, 14:2149-2158
Published Date: 3 June 2020
Network Pharmacology and Experimental Evidence Reveal Dioscin Suppresses Proliferation, Invasion, and EMT via AKT/GSK3b/mTOR Signaling in Lung Adenocarcinoma
Mao W, Yin H, Chen W, Zhao T, Wu S, Jin H, Du B, Tan Y, Zhang R, He Y
Drug Design, Development and Therapy 2020, 14:2135-2147
Published Date: 28 May 2020
A Comparison of Dexmedetomidine and Midazolam for the Prevention of Postoperative Nausea and Vomiting Caused by Hemabate in Cesarean Delivery: A Randomized Controlled Trial
Hu B, Zhou H, Zou X, Shi J, Li X, Tan L
Drug Design, Development and Therapy 2020, 14:2127-2133
Published Date: 28 May 2020
In situ Delivery of Thermosensitive Gel-Mediated 5-Fluorouracil Microemulsion for the Treatment of Colorectal Cancer [Corrigendum]
Wang L, Huang S, Guo H, Han Y, Zheng W, Jiang J
Drug Design, Development and Therapy 2020, 14:2125-2126
Published Date: 28 May 2020
Effect of Lactoferrin Protein on Red Blood Cells and Macrophages: Mechanism of Parasite–Host Interaction [Corrigendum]
Anand N, Kanwar R, Dubey M, Vahishta RK, Sehgal R, Verma A, Kanwar J
Drug Design, Development and Therapy 2020, 14:2123-2124
Published Date: 28 May 2020
Epigallocatechin-3-Gallate Protects H2O2-Induced Nucleus Pulposus Cell Apoptosis and Inflammation by Inhibiting cGAS/Sting/NLRP3 Activation
Tian Y, Bao Z, Ji Y, Mei X, Yang H
Drug Design, Development and Therapy 2020, 14:2113-2122
Published Date: 27 May 2020
A Pharmacokinetic Drug Interaction Between Fimasartan and Linagliptin in Healthy Volunteers
Kang WY, Lee HW, Gwon MR, Cho S, Shim WS, Lee KT, Yang DH, Seong SJ, Yoon YR
Drug Design, Development and Therapy 2020, 14:2101-2111
Published Date: 26 May 2020
Dihydroartemisinin Inhibits the Proliferation of Leukemia Cells K562 by Suppressing PKM2 and GLUT1 Mediated Aerobic Glycolysis
Gao P, Shen S, Li X, Liu D, Meng Y, Liu Y, Zhu Y, Zhang J, Luo P, Gu L
Drug Design, Development and Therapy 2020, 14:2091-2100
Published Date: 27 May 2020
Resveratrol Exerts Anti-Osteoarthritic Effect by Inhibiting TLR4/NF-κB Signaling Pathway via the TLR4/Akt/FoxO1 Axis in IL-1β-Stimulated SW1353 Cells
Xu X, Liu X, Yang Y, He J, Jiang M, Huang Y, Liu X, Liu L, Gu H
Drug Design, Development and Therapy 2020, 14:2079-2090
Published Date: 26 May 2020
Synthesis and Biological Activity of Piperine Derivatives as Potential PPARγ Agonists
Wang Y, Yao Y, Liu J, Wu L, Liu T, Cui J, Lee DYW
Drug Design, Development and Therapy 2020, 14:2069-2078
Published Date: 26 May 2020
An LC-MS/MS Bioanalytical Assay for the Determination of Gilteritinib in Rat Plasma and Application to a Drug–Drug Interaction Study
Wang Q, Chen Z, Chen D, Ye X
Drug Design, Development and Therapy 2020, 14:2061-2067
Published Date: 26 May 2020
Melatonin Attenuates Anoxia/Reoxygenation Injury by Inhibiting Excessive Mitophagy Through the MT2/SIRT3/FoxO3a Signaling Pathway in H9c2 Cells
Wu J, Yang Y, Gao Y, Wang Z, Ma J
Drug Design, Development and Therapy 2020, 14:2047-2060
Published Date: 25 May 2020
Improvement of Pain Relief of Fentanyl Citrate Drug Encapsulated in Nanostructured Lipid Carrier: Drug Formulation, Parameter Optimization, in vitro and in vivo Studies
Bahrami MA, Farhadian N, Karimi M, Forouzan A, Masoumi K
Drug Design, Development and Therapy 2020, 14:2033-2045
Published Date: 25 May 2020
Glycine Improves Ischemic Stroke Through miR-19a-3p/AMPK/GSK-3β/HO-1 Pathway
Chen ZJ, Zhao XS, Fan TP, Qi HX, Li D
Drug Design, Development and Therapy 2020, 14:2021-2031
Published Date: 25 May 2020
A Triple Combination of Metformin, Acetylsalicylic Acid, and Oseltamivir Phosphate Impacts Tumour Spheroid Viability and Upends Chemoresistance in Triple-Negative Breast Cancer
Sambi M, Samuel V, Qorri B, Haq S, Burov SV, Markvicheva E, Harless W, Szewczuk MR
Drug Design, Development and Therapy 2020, 14:1995-2019
Published Date: 25 May 2020
Activation of Cholinergic Anti-Inflammatory Pathway in Peripheral Immune Cells Involved in Therapeutic Actions of α-Mangostin on Collagen-Induced Arthritis in Rats
Yin Q, Wu Y, Pan S, Wang D, Tao M, Pei W, Zuo J
Drug Design, Development and Therapy 2020, 14:1983-1993
Published Date: 22 May 2020
Emodin Protects Against Acute Pancreatitis-Associated Lung Injury by Inhibiting NLPR3 Inflammasome Activation via Nrf2/HO-1 Signaling
Gao Z, Sui J, Fan R, Qu W, Dong X, Sun D
Drug Design, Development and Therapy 2020, 14:1971-1982
Published Date: 21 May 2020
Effects of Apatinib on the Pharmacokinetics of Nifedipine and Warfarin in Patients with Advanced Solid Tumors
Zhu YT, Teng Z, Zhang YF, Li W, Guo LX, Liu YP, Qu XJ, Wang QR, Mao SY, Chen XY, Zhong DF
Drug Design, Development and Therapy 2020, 14:1963-1970
Published Date: 20 May 2020
Comparison of the Pharmacokinetics of Highly Variable Drugs in Healthy Subjects Using a Partial Replicated Crossover Study: A Fixed-Dose Combination of Fimasartan 120 mg and Atorvastatin 40 mg versus Separate Tablets
Hwang JG, Yu KS, Lee S
Drug Design, Development and Therapy 2020, 14:1953-1961
Published Date: 20 May 2020
The NK-1R Antagonist Aprepitant Prevents LPS-Induced Oxidative Stress and Inflammation in RAW264.7 Macrophages
Zhao X, Bai Z, Li C, Sheng C, Li H
Drug Design, Development and Therapy 2020, 14:1943-1952
Published Date: 20 May 2020
Alleviation of Liver Dysfunction, Oxidative Stress and Inflammation Underlies the Protective Effect of Ferulic Acid in Methotrexate-Induced Hepatotoxicity
Roghani M, Kalantari H, Khodayar MJ, Khorsandi L, Kalantar M, Goudarzi M, Kalantar H
Drug Design, Development and Therapy 2020, 14:1933-1941
Published Date: 20 May 2020
Protective Effects of Crocetin on Arsenic Trioxide-Induced Hepatic Injury: Involvement of Suppression in Oxidative Stress and Inflammation Through Activation of Nrf2 Signaling Pathway in Rats
Liu Y, Liang Y, Zheng B, Chu L, Ma D, Wang H, Chu X, Zhang J
Drug Design, Development and Therapy 2020, 14:1921-1931
Published Date: 19 May 2020
Inhibitory Effect of Lygodium Root on the Cytochrome P450 3A Enzyme in vitro and in vivo
Zhou Y, Hua A, Zhou Q, Geng P, Chen F, Yan L, Wang S, Wen C
Drug Design, Development and Therapy 2020, 14:1909-1919
Published Date: 19 May 2020
Leflunomide Inhibits Proliferation and Induces Apoptosis via Suppressing Autophagy and PI3K/Akt Signaling Pathway in Human Bladder Cancer Cells
Cheng L, Wang H, Wang Z, Huang H, Zhuo D, Lin J
Drug Design, Development and Therapy 2020, 14:1897-1908
Published Date: 18 May 2020
Leonurine Promotes Cisplatin Sensitivity in Human Cervical Cancer Cells Through Increasing Apoptosis and Inhibiting Drug-Resistant Proteins
Lin M, Pan C, Xu W, Li J, Zhu X
Drug Design, Development and Therapy 2020, 14:1885-1895
Published Date: 15 May 2020
Bacteriophages, a New Therapeutic Solution for Inhibiting Multidrug-Resistant Bacteria Causing Wound Infection: Lesson from Animal Models and Clinical Trials
Taati Moghadam M, Khoshbayan A, Chegini Z, Farahani I, Shariati A
Drug Design, Development and Therapy 2020, 14:1867-1883
Published Date: 15 May 2020
Applying Different Techniques to Improve the Bioavailability of Candesartan Cilexetil Antihypertensive Drug
Aly UF, Sarhan HA, Ali TFS, Sharkawy HAEB
Drug Design, Development and Therapy 2020, 14:1851-1865
Published Date: 14 May 2020
Pharmacokinetics and Metabolism Research of Shenkang Injection in Rats Based on UHPLC-MS/MS and UHPLC-Q-Orbitrap HRMS
Jiang X, Zhou L, Zuo L, Wang X, Shi Y, Du X, Zhang J, Liu L, Li Z, Xue L, Liu X, Sun Z
Drug Design, Development and Therapy 2020, 14:1837-1850
Published Date: 13 May 2020
Cationic/Anionic Polyelectrolyte (PLL/PGA) Coated Vesicular Phospholipid Gels (VPGs) Loaded with Cytarabine for Sustained Release and Anti-glioma Effects
Qi N, Zhang Y, Tang X, Li A
Drug Design, Development and Therapy 2020, 14:1825-1836
Published Date: 12 May 2020
Berberine Induces Autophagic Cell Death in Acute Lymphoblastic Leukemia by Inactivating AKT/mTORC1 Signaling
Liu J, Liu P, Xu T, Chen Z, Kong H, Chu W, Wang Y, Liu Y
Drug Design, Development and Therapy 2020, 14:1813-1823
Published Date: 12 May 2020
Pranlukast Antagonizes CD49f and Reduces Stemness in Triple-Negative Breast Cancer Cells
Velázquez-Quesada I, Ruiz-Moreno AJ, Casique-Aguirre D, Aguirre-Alvarado C, Cortés-Mendoza F, de la Fuente-Granada M, García-Pérez C, Pérez-Tapia SM, González-Arenas A, Segura-Cabrera A, Velasco-Velázquez MA
Drug Design, Development and Therapy 2020, 14:1799-1811
Published Date: 12 May 2020
Virtual Screening and Optimization of Novel mTOR Inhibitors for Radiosensitization of Hepatocellular Carcinoma
Feng YQ, Gu SX, Chen YS, Gao XD, Ren YX, Chen JC, Lu YY, Zhang H, Cao S
Drug Design, Development and Therapy 2020, 14:1779-1798
Published Date: 8 May 2020
Salvianolic Acid A Exhibits Anti-Inflammatory and Antiarthritic Effects via Inhibiting NF-κB and p38/MAPK Pathways
Feng S, Cong H, Ji L
Drug Design, Development and Therapy 2020, 14:1771-1778
Published Date: 8 May 2020
Dupilumab: Clinical Efficacy of Blocking IL-4/IL-13 Signalling in Chronic Rhinosinusitis with Nasal Polyps
Kariyawasam HH, James LK, Gane SB
Drug Design, Development and Therapy 2020, 14:1757-1769
Published Date: 8 May 2020
The Usefulness of Platelet-Rich Plasma (PRP) for the Treatment of Vitiligo: State of the Art and Review
Mercuri SR, Vollono L, Paolino G
Drug Design, Development and Therapy 2020, 14:1749-1755
Published Date: 7 May 2020
Investigation of the Inhibitory Effect of Simvastatin on the Metabolism of Lidocaine Both in vitro and in vivo
Wang Y, Ou-yang Q, Huang W, Huang H, Zhuang X, Lin Q, Zeng D
Drug Design, Development and Therapy 2020, 14:1739-1747
Published Date: 6 May 2020
Pharmacokinetic Evaluation by Modeling and Simulation Analysis of a Donepezil Patch Formulation in Healthy Male Volunteers
Yoon SK, Bae KS, Hong DH, Kim SS, Choi YK, Lim HS
Drug Design, Development and Therapy 2020, 14:1729-1737
Published Date: 5 May 2020
High ACTN1 Is Associated with Poor Prognosis, and ACTN1 Silencing Suppresses Cell Proliferation and Metastasis in Oral Squamous Cell Carcinoma
Xie G, Zhao L, Chen Q, Tang D, Chen Q, Lu H, Cai J, Chen Z
Drug Design, Development and Therapy 2020, 14:1717-1727
Published Date: 5 May 2020
Chlorogenic Acid Alleviates Aβ25-35-Induced Autophagy and Cognitive Impairment via the mTOR/TFEB Signaling Pathway
Gao L, Li X, Meng S, Ma T, Wan L, Xu S
Drug Design, Development and Therapy 2020, 14:1705-1716
Published Date: 4 May 2020
Pexidartinib, a Novel Small Molecule CSF-1R Inhibitor in Use for Tenosynovial Giant Cell Tumor: A Systematic Review of Pre-Clinical and Clinical Development
Benner B, Good L, Quiroga D, Schultz TE, Kassem M, Carson WE, Cherian MA, Sardesai S, Wesolowski R
Drug Design, Development and Therapy 2020, 14:1693-1704
Published Date: 4 May 2020
Laquinimod Protects Against TNF-α-Induced Attachment of Monocytes to Human Aortic Endothelial Cells (HAECs) by Increasing the Expression of KLF2
Jiang T, Zhang W, Wang Z
Drug Design, Development and Therapy 2020, 14:1683-1691
Published Date: 30 April 2020
Pharmacokinetic-Based Drug–Drug Interactions with Anaplastic Lymphoma Kinase Inhibitors: A Review
Zhao D, Chen J, Chu M, Long X, Wang J
Drug Design, Development and Therapy 2020, 14:1663-1681
Published Date: 30 April 2020
Astaxanthin Attenuates Neuroinflammation in Status Epilepticus Rats by Regulating the ATP-P2X7R Signal
Wang M, Deng X, Xie Y, Chen Y
Drug Design, Development and Therapy 2020, 14:1651-1662
Published Date: 30 April 2020
Arsenic Disulfide Promoted Hypomethylation by Increasing DNA Methyltransferases Expression in Myelodysplastic Syndrome
Zhou QB, Liu ZT, Wang HZ, Guo XQ, Xu YG, Hu XM
Drug Design, Development and Therapy 2020, 14:1641-1650
Published Date: 30 April 2020
Effect of Eriodictyol on Collagen-Induced Arthritis in Rats by Akt/HIF-1α Pathway
Lei Z, Ouyang L, Gong Y, Wang Z, Yu B
Drug Design, Development and Therapy 2020, 14:1633-1639
Published Date: 29 April 2020
Bone Marrow Mesenchymal Stem Cell-Derived Exosomes Improves Spinal Cord Function After Injury in Rats by Activating Autophagy
Gu J, Jin ZS, Wang CM, Yan XF, Mao YQ, Chen S
Drug Design, Development and Therapy 2020, 14:1621-1631
Published Date: 29 April 2020
Anisodamine Suppressed the Growth of Hepatocellular Carcinoma Cells, Induced Apoptosis and Regulated the Levels of Inflammatory Factors by Inhibiting NLRP3 Inflammasome Activation
Li P, Liu Y, He Q
Drug Design, Development and Therapy 2020, 14:1609-1620
Published Date: 29 April 2020
In vitro Multistage Malaria Transmission Blocking Activity of Selected Malaria Box Compounds
Malebo HM, D'Alessandro S, Ebstie YA, Sorè H, Tenoh Guedoung AR, Katani SJ, Parapini S, Taramelli D, Habluetzel A
Drug Design, Development and Therapy 2020, 14:1593-1607
Published Date: 28 April 2020
Gallic Acid Impedes Non-Small Cell Lung Cancer Progression via Suppression of EGFR-Dependent CARM1-PELP1 Complex
Wang D, Bao B
Drug Design, Development and Therapy 2020, 14:1583-1592
Published Date: 23 April 2020
Experimental Study on the Role of Apelin-13 in Alleviating Spinal Cord Ischemia Reperfusion Injury Through Suppressing Autophagy
Xu Z, Li Z
Drug Design, Development and Therapy 2020, 14:1571-1581
Published Date: 22 April 2020
Metformin Inhibits Propofol-Induced Apoptosis of Mouse Hippocampal Neurons HT-22 Through Downregulating Cav-1
Ge J, Huang Y, Zhang Y, Liu L, Gu T, Liu X, Yao L, Cai M, Sun J, Song J
Drug Design, Development and Therapy 2020, 14:1561-1569
Published Date: 21 April 2020
ACE2 Attenuates Epithelial-Mesenchymal Transition in MLE-12 Cells Induced by Silica
Li S, Li Y, Xu H, Wei Z, Yang Y, Jin F, Zhang M, Wang C, Song W, Huo J, Zhao J, Yang X, Yang F
Drug Design, Development and Therapy 2020, 14:1547-1559
Published Date: 21 April 2020
Selection and Characterization of a Novel DNA Aptamer, Apt-07S Specific to Hepatocellular Carcinoma Cells
Yu XX, Ge KL, Liu N, Zhang JY, Xue ML, Ge YL
Drug Design, Development and Therapy 2020, 14:1535-1545
Published Date: 20 April 2020
Salvianolic Acid Alleviated Blood–Brain Barrier Permeability in Spontaneously Hypertensive Rats by Inhibiting Apoptosis in Pericytes via P53 and the Ras/Raf/MEK/ERK Pathway
Wu Q, Yuan X, Li B, Han R, Zhang H, Xiu R
Drug Design, Development and Therapy 2020, 14:1523-1534
Published Date: 16 April 2020
Optimal Approach and Strategies to Strengthen Pharmacovigilance in Sub-Saharan Africa: A Cohort Study of Patients Treated with First-Line Artemisinin-Based Combination Therapies in the Nanoro Health and Demographic Surveillance System, Burkina Faso
Rouamba T, Sondo P, Derra K, Nakanabo-Diallo S, Bihoun B, Rouamba E, Tarnagda Z, Kazienga A, Valea I, Sorgho H, Pagnoni F, Samadoulougou-Kirakoya F, Tinto H
Drug Design, Development and Therapy 2020, 14:1507-1521
Published Date: 16 April 2020
Radix Polygoni Multiflori and Its Main Component Emodin Attenuate Non-Alcoholic Fatty Liver Disease in Zebrafish by Regulation of AMPK Signaling Pathway
Yu L, Gong L, Wang C, Hu N, Tang Y, Zheng L, Dai X, Li Y
Drug Design, Development and Therapy 2020, 14:1493-1506
Published Date: 15 April 2020
Formulation, Preparation and Evaluation of Nanostructured Lipid Carrier Containing Naringin and Coix Seed Oil for Anti-Tumor Application Based on “Unification of Medicines and Excipients”
Zhu J, Huang Y, Zhang J, Feng Y, Shen L
Drug Design, Development and Therapy 2020, 14:1481-1491
Published Date: 16 April 2020
The Effect of Liver and Kidney Disease on the Pharmacokinetics of Clozapine and Sildenafil: A Physiologically Based Pharmacokinetic Modeling
Ghoneim AM, Mansour SM
Drug Design, Development and Therapy 2020, 14:1469-1479
Published Date: 14 April 2020
Isoliquiritigenin Attenuates UUO-Induced Renal Inflammation and Fibrosis by Inhibiting Mincle/Syk/NF-Kappa B Signaling Pathway
Liao Y, Tan R, Li J, Liu T, Zhong X, Yan Y, Yang J, Lin X, Fan J, Wang L
Drug Design, Development and Therapy 2020, 14:1455-1468
Published Date: 14 April 2020
Salidroside Alleviates Cartilage Degeneration Through NF-κB Pathway in Osteoarthritis Rats
Gao H, Peng L, Li C, Ji Q, Li P
Drug Design, Development and Therapy 2020, 14:1445-1454
Published Date: 14 April 2020
Metabolite Profiling in Anticancer Drug Development: A Systematic Review
Muhamad N, Na-Bangchang K
Drug Design, Development and Therapy 2020, 14:1401-1444
Published Date: 9 April 2020
Update on Eluxadoline for the Treatment of Irritable Bowel Syndrome with Diarrhea: Patient Selection and Perspectives
Liu R, Staller K
Drug Design, Development and Therapy 2020, 14:1391-1400
Published Date: 9 April 2020
MsrA Suppresses Inflammatory Activation of Microglia and Oxidative Stress to Prevent Demyelination via Inhibition of the NOX2-MAPKs/NF-κB Signaling Pathway
Fan H, Li D, Guan X, Yang Y, Yan J, Shi J, Ma R, Shu Q
Drug Design, Development and Therapy 2020, 14:1377-1389
Published Date: 5 April 2020
One-Pot Synthesis of Novel Thiazoles as Potential Anti-Cancer Agents
Sayed AR, Gomha SM, Taher EA, Muhammad ZA, El-Seedi HR, Gaber HM, Ahmed MM
Drug Design, Development and Therapy 2020, 14:1363-1375
Published Date: 3 April 2020
Desflurane Preconditioning Protects Against Renal Ischemia–Reperfusion Injury and Inhibits Inflammation and Oxidative Stress in Rats Through Regulating the Nrf2-Keap1-ARE Signaling Pathway
Zheng Y, Lu H, Huang H
Drug Design, Development and Therapy 2020, 14:1351-1362
Published Date: 3 April 2020
Long-Term Safety of a Novel Angiotensin Receptor Blocker, Fimasartan, According to the Absence or Presence of Underlying Liver Disease in Korean Hypertensive Patients: A Prospective, 12-Month, Observational Study
Oh GC, Joo KW, Kim MA, Choi DJ, Kim YJ, Lee HY
Drug Design, Development and Therapy 2020, 14:1341-1349
Published Date: 3 April 2020
The Efficacy of N-Butylphthalide and Dexamethasone Combined with Hyperbaric Oxygen on Delayed Encephalopathy After Acute Carbon Monoxide Poisoning
Zhang J, Guo Y, Li W, Li G, Chen Y
Drug Design, Development and Therapy 2020, 14:1333-1339
Published Date: 2 April 2020
Proniosomal Telmisartan Tablets: Formulation, in vitro Evaluation and in vivo Comparative Pharmacokinetic Study in Rabbits
Teaima MH, Yasser M, El-Nabarawi MA, Helal DA
Drug Design, Development and Therapy 2020, 14:1319-1331
Published Date: 31 March 2020
Leishmania donovani Growth Inhibitors from Pathogen Box Compounds of Medicine for Malaria Venture
Tadele M, Abay SM, Makonnen E, Hailu A
Drug Design, Development and Therapy 2020, 14:1307-1317
Published Date: 31 March 2020
Alginate Suppresses Liver Fibrosis Through the Inhibition of Nuclear Factor-κB Signaling
Xia Z, Ding L, Zheng J, Xu Y, Jin W, Sheng X, Wu J
Drug Design, Development and Therapy 2020, 14:1295-1305
Published Date: 31 March 2020
Diterpene Ginkgolides Exert an Antidepressant Effect Through the NT3-TrkA and Ras-MAPK Pathways
Wang T, Bai S, Wang W, Chen Z, Chen J, Liang Z, Qi X, Shen H, Xie P
Drug Design, Development and Therapy 2020, 14:1279-1294
Published Date: 31 March 2020
Pre-Clinical Pharmacokinetics, Tissue Distribution and Physicochemical Studies of CLBQ14, a Novel Methionine Aminopeptidase Inhibitor for the Treatment of Infectious Diseases
Ekpenyong O, Gao X, Ma J, Cooper C, Nguyen L, Olaleye OA, Liang D, Xie H
Drug Design, Development and Therapy 2020, 14:1263-1277
Published Date: 30 March 2020
Safety and Feasibility of Low-Dose Apatinib Combined with S-1 as the Second-Line Therapy or Beyond in Chinese Patients with Pulmonary and Hepatic Metastasis of Nasopharyngeal Carcinoma
Zhou L, Lin J, Wu G, Chen J, Huang X, Zhang S
Drug Design, Development and Therapy 2020, 14:1257-1262
Published Date: 30 March 2020
Growth Factor Gene-Modified Mesenchymal Stem Cells in Tissue Regeneration
Nie WB, Zhang D, Wang LS
Drug Design, Development and Therapy 2020, 14:1241-1256
Published Date: 26 March 2020
Morusin Ameliorates IL-1β-Induced Chondrocyte Inflammation and Osteoarthritis via NF-κB Signal Pathway
Jia Y, He W, Zhang H, He L, Wang Y, Zhang T, Peng J, Sun P, Qian Y
Drug Design, Development and Therapy 2020, 14:1227-1240
Published Date: 26 March 2020
Comparison of Pharmacokinetics of Aprepitant in Healthy Chinese and Caucasian Subjects
Yang MJ, Xu HR, Li H, Chen WL, Yuan F, Li XN
Drug Design, Development and Therapy 2020, 14:1219-1226
Published Date: 24 March 2020
Miconazole Contributes to NRF2 Activation by Noncanonical P62-KEAP1 Pathway in Bladder Cancer Cells
Tsai TF, Chen PC, Lin YC, Chou KY, Chen HE, Ho CY, Lin JF, Hwang TIS
Drug Design, Development and Therapy 2020, 14:1209-1218
Published Date: 24 March 2020
Effects of Cisatracurium, Rocuronium, and Mivacurium on Intraocular Pressure During Induction of General Anesthesia in Ophthalmic Surgery
Li S, Hu X, Tan F, Li W
Drug Design, Development and Therapy 2020, 14:1203-1208
Published Date: 24 March 2020
Paeoniflorin Ameliorates Chronic Hypoxia/SU5416-Induced Pulmonary Arterial Hypertension by Inhibiting Endothelial-to-Mesenchymal Transition
Yu M, Peng L, Liu P, Yang M, Zhou H, Ding Y, Wang J, Huang W, Tan Q, Wang Y, Xie W, Kong H, Wang H
Drug Design, Development and Therapy 2020, 14:1191-1202
Published Date: 19 March 2020
A First-in-Human Dose Finding Study of Camrelizumab in Patients with Advanced or Metastatic Cancer in Australia
Lickliter JD, Gan HK, Voskoboynik M, Arulananda S, Gao B, Nagrial A, Grimison P, Harrison M, Zou J, Zhang L, Luo S, Lahn M, Kallender H, Mannucci A, Somma C, Woods K, Behren A, Fernandez-Penas P, Millward M, Meniawy T
Drug Design, Development and Therapy 2020, 14:1177-1189
Published Date: 18 March 2020
Stability and Compatibility of Ramosetron with Midazolam in 0.9% Sodium Chloride Injection for Postoperative Nausea and Vomiting Administration
Xia J, Chen P
Drug Design, Development and Therapy 2020, 14:1169-1176
Published Date: 17 March 2020
1,25(OH)2D3 Strengthens the Vasculogenesis of Multipotent Mesenchymal Stromal Cells from Rat Bone Marrow by Regulating the PI3K/AKT Pathway
Ye B, Weng Y, Lin S, Lin J, Huang Z, Huang W, Cai X
Drug Design, Development and Therapy 2020, 14:1157-1167
Published Date: 16 March 2020
Validation of the Key Active Ingredients and Anti-Inflammatory and Analgesic Effects of Shenjin Huoxue Mixture Against Osteoarthritis by Integrating Network Pharmacology Approach and Thin-Layer Chromatography Analysis
Yu MX, Ma XQ, Song X, Huang YM, Jiang HT, Wang J, Yang WH
Drug Design, Development and Therapy 2020, 14:1145-1156
Published Date: 16 March 2020
Tetrandrine Suppresses Transient Receptor Potential Cation Channel Protein 6 Overexpression- Induced Podocyte Damage via Blockage of RhoA/ROCK1 Signaling [Corrigendum]
Yu J, Zhu C, Yin J, Yu D, Wan F, Tang X, Jiang X
Drug Design, Development and Therapy 2020, 14:1143-1144
Published Date: 13 March 2020
miR-370-3p Alleviates Ulcerative Colitis-Related Colorectal Cancer in Mice Through Inhibiting the Inflammatory Response and Epithelial-Mesenchymal Transition
Lin L, Wang D, Qu S, Zhao H, Lin Y
Drug Design, Development and Therapy 2020, 14:1127-1141
Published Date: 13 March 2020
Simultaneous Determination of Parecoxib and Its Metabolite Valdecoxib Concentrations in Beagle Plasma by UPLC-MS/MS and Application for Pharmacokinetics Study
Li S, Zhu Y, Zhu C, Li S, Li Z, Qiu X
Drug Design, Development and Therapy 2020, 14:1117-1125
Published Date: 13 March 2020
PD98059 Protects Cerebral Cortex Mitochondrial Structure and Function at 48 h Post-Resuscitation in a Rat Model of Cardiac Arrest
Zheng JH, Chen MH, Fu ZY, Li N, Xie L
Drug Design, Development and Therapy 2020, 14:1107-1115
Published Date: 12 March 2020
Hyaluronic Acid Capped, Irinotecan and Gene Co-Loaded Lipid-Polymer Hybrid Nanocarrier-Based Combination Therapy Platform for Colorectal Cancer
Wang Z, Zang A, Wei Y, An L, Hong D, Shi Y, Zhang J, Su S, Fang G
Drug Design, Development and Therapy 2020, 14:1095-1105
Published Date: 12 March 2020
Impact of Intraoperative Infusion and Postoperative PCIA of Dexmedetomidine on Early Breastfeeding After Elective Cesarean Section: A Randomized Double-Blind Controlled Trial
Wang Y, Fang X, Liu C, Ma X, Song Y, Yan M
Drug Design, Development and Therapy 2020, 14:1083-1093
Published Date: 11 March 2020
Review on the Structures and Activities of Transthyretin Amyloidogenesis Inhibitors
Guo X, Liu Z, Zheng Y, Li Y, Li L, Liu H, Chen Z, Wu L
Drug Design, Development and Therapy 2020, 14:1057-1081
Published Date: 10 March 2020
KLF6 Induces Apoptosis in Human Lens Epithelial Cells Through the ATF4-ATF3-CHOP Axis
Tian F, Zhao J, Bu S, Teng H, Yang J, Zhang X, Li X, Dong L
Drug Design, Development and Therapy 2020, 14:1041-1055
Published Date: 9 March 2020
In silico Design and Synthesis of Tetrahydropyrimidinones and Tetrahydropyrimidinethiones as Potential Thymidylate Kinase Inhibitors Exerting Anti-TB Activity Against Mycobacterium tuberculosis
Venugopala KN, Tratrat C, Pillay M, Chandrashekharappa S, Al-Attraqchi OHA, Aldhubiab BE, Attimarad M, Alwassil OI, Nair AB, Sreeharsha N, Venugopala R, Morsy MA, Haroun M, Kumalo HM, Odhav B, Mlisana K
Drug Design, Development and Therapy 2020, 14:1027-1039
Published Date: 9 March 2020
The Use of Peripheral μ-Opioid Receptor Antagonists (PAMORA) in the Management of Opioid-Induced Constipation: An Update on Their Efficacy and Safety
Pergolizzi JV Jr, Christo PJ, LeQuang JA, Magnusson P
Drug Design, Development and Therapy 2020, 14:1009-1025
Published Date: 11 March 2020
Characterization and Evaluation of Antioxidant Activity of Aloe schelpei Reynolds
Teka T, Kassahun H
Drug Design, Development and Therapy 2020, 14:1003-1008
Published Date: 5 March 2020
Bisdemethoxycurcumin Inhibits Hepatocellular Carcinoma Proliferation Through Akt Inactivation via CYLD-Mediated Deubiquitination
Qiu C, Liu K, Zhang S, Gao S, Chen W, Li D, Huang Y
Drug Design, Development and Therapy 2020, 14:993-1001
Published Date: 5 March 2020
Study on the Formation of Antihypertensive Twin Drugs by Caffeic Acid and Ferulic Acid with Telmisartan
Li P, Peng Y, Ma Q, Li Z, Zhang X
Drug Design, Development and Therapy 2020, 14:977-992
Published Date: 5 March 2020
Annatto-Derived Tocotrienol Promotes Mineralization of MC3T3-E1 Cells by Enhancing BMP-2 Protein Expression via Inhibiting RhoA Activation and HMG-CoA Reductase Gene Expression
Wan Hasan WN, Chin KY, Abd Ghafar N, Soelaiman IN
Drug Design, Development and Therapy 2020, 14:969-976
Published Date: 3 March 2020
Perindopril in Breast Milk and Determination of Breastfed Infant Exposure: A Prospective Observational Study
Leggett C, Lwin EMP, Ritchie U, Song Y, Gerber JP, Turner S, Hague WM, Stark M, Upton R, Garg S
Drug Design, Development and Therapy 2020, 14:961-967
Published Date: 2 March 2020
Finasteride and Its Potential for the Treatment of Female Pattern Hair Loss: Evidence to Date
Iamsumang W, Leerunyakul K, Suchonwanit P
Drug Design, Development and Therapy 2020, 14:951-959
Published Date: 2 March 2020
A Network Pharmacology-Based Strategy for Predicting Active Ingredients and Potential Targets of LiuWei DiHuang Pill in Treating Type 2 Diabetes Mellitus [Corrigendum]
He D, Huang JH, Zhang ZY, Du Q, Peng WJ, Yu R, Zhang SF, Zhang SH, Qin YH
Drug Design, Development and Therapy 2020, 14:949-950
Published Date: 2 March 2020
The Traditional Chinese Medicine Compound, GRS, Alleviates Blood–Brain Barrier Dysfunction
Zhang Y, Hu Y, Li M, Wang J, Guo G, Li F, Yu B, Kou J
Drug Design, Development and Therapy 2020, 14:933-947
Published Date: 28 February 2020
Oxymatrine Liposomes for Intervertebral Disc Treatment: Formulation, in vitro and vivo Assessments
Wang H, Ding Y, Zhang W, Wei K, Pei Y, Zou C, Zhang C, Ding J, Fang H, Tan S
Drug Design, Development and Therapy 2020, 14:921-931
Published Date: 28 February 2020
Effect and Molecular Mechanisms of Traditional Chinese Medicine on Tumor Targeting Tumor-Associated Macrophages
He J, Yin P, Xu K
Drug Design, Development and Therapy 2020, 14:907-919
Published Date: 28 February 2020
miR-346 Inhibited Apoptosis Against Myocardial Ischemia-Reperfusion Injury via Targeting Bax in Rats
Lv X, Lu P, Hu Y, Xu T
Drug Design, Development and Therapy 2020, 14:895-905
Published Date: 27 February 2020
Pleiotropic Anticancer Properties of Scorpion Venom Peptides: Rhopalurus princeps Venom as an Anticancer Agent
Mikaelian AG, Traboulay E, Zhang XM, Yeritsyan E, Pedersen PL, Ko YH, Matalka KZ
Drug Design, Development and Therapy 2020, 14:881-893
Published Date: 27 February 2020
Comparative Assessment of Distribution Characteristics and Ocular Pharmacokinetics of Norvancomycin Between Continuous Topical Ocular Instillation and Hourly Administration of Eye Drop
Lin W, Zhao L, Huang X, Tan Q, Peng M, Khan MA, Lin D
Drug Design, Development and Therapy 2020, 14:867-879
Published Date: 26 February 2020
Inhibitory Effect of Curcumin on Artery Restenosis Following Carotid Endarterectomy and Its Associated Mechanism in vitro and in vivo
Zhang D, Yang Y, Li Y, Zhang G, Cheng Z
Drug Design, Development and Therapy 2020, 14:855-866
Published Date: 26 February 2020
The Advantages of Levodopa-Carbidopa Intestinal Gel for Patients with Advanced Parkinson’s Disease: A Systematic Review
Zhang XR, Jiang ZY, Zhang ZR, Chen HJ, Wu K, He JC, Xie CL
Drug Design, Development and Therapy 2020, 14:845-854
Published Date: 26 February 2020
AZD4547 Attenuates Lipopolysaccharide-Induced Acute Kidney Injury by Inhibiting Inflammation: The Role of FGFR1 in Renal Tubular Epithelial Cells
Chen X, Zhang X, Xu J, Zhao Y, Bao J, Zheng Z, Han J
Drug Design, Development and Therapy 2020, 14:833-844
Published Date: 26 February 2020
Combination Treatment of Cervical Cancer Using Folate-Decorated, pH-Sensitive, Carboplatin and Paclitaxel Co-Loaded Lipid-Polymer Hybrid Nanoparticles
Wang J
Drug Design, Development and Therapy 2020, 14:823-832
Published Date: 26 February 2020
Contribution of Trough Concentration Data in the Evaluation of Multiple-Dose Pharmacokinetics for Drugs with Delayed Distributional Equilibrium and Long Half-Life
Choi S, Jeon S, Yim DS, Han S
Drug Design, Development and Therapy 2020, 14:811-821
Published Date: 25 February 2020
Ubiquitin-Fold Modifier-1 Participates in the Diabetic Inflammatory Response by Regulating NF-κB p65 Nuclear Translocation and the Ubiquitination and Degradation of IκBα
Hu X, Zhang H, Zhuang L, Jin G, Yang Q, Li M, Sun W, Chen F
Drug Design, Development and Therapy 2020, 14:795-810
Published Date: 25 February 2020
Metabolic Stability Assessment of New PARP Inhibitor Talazoparib Using Validated LC–MS/MS Methodology: In silico Metabolic Vulnerability and Toxicity Studies
Attwa MW, Kadi AA, Abdelhameed AS, Alhazmi HA
Drug Design, Development and Therapy 2020, 14:783-793
Published Date: 25 February 2020
Fisetin Modulates Human Oral Squamous Cell Carcinoma Proliferation by Blocking PAK4 Signaling Pathways
Li Y, Jia S, Dai W
Drug Design, Development and Therapy 2020, 14:773-782
Published Date: 25 February 2020
Metalloprotoporphyrin Inhibition of HCV NS3-4A Protease: Structure–Activity Relationships
Hu K, Zhu Z, Mathahs MM, Tran H, Bommer J, Testa CA, Schmidt WN
Drug Design, Development and Therapy 2020, 14:757-771
Published Date: 24 February 2020
NVP-BSK805, an Inhibitor of JAK2 Kinase, Significantly Enhances the Radiosensitivity of Esophageal Squamous Cell Carcinoma in vitro and in vivo
Hua Y, Wang W, Zheng X, Yang L, Wu H, Hu Z, Li Y, Yue J, Jiang Z, Zhang X, Hou Q, Wu S
Drug Design, Development and Therapy 2020, 14:745-755
Published Date: 24 February 2020
Ox-LDL Causes Endothelial Cell Injury Through ASK1/NLRP3-Mediated Inflammasome Activation via Endoplasmic Reticulum Stress
Hang L, Peng Y, Xiang R, Li X, Li Z
Drug Design, Development and Therapy 2020, 14:731-744
Published Date: 24 February 2020
Synthesis, Characterization, and Pharmacodynamics Study of Enrofloxacin Mesylate
Pei L, Yang W, Fu J, Liu M, Zhang T, Li D, Huang R, Zhang L, Peng G, Shu G, Yuan Z, Lin J, Zhang W, Zhong Z, Zhao L, Fu H
Drug Design, Development and Therapy 2020, 14:715-730
Published Date: 24 February 2020
Anti-Inflammatory Activity of Sanjie Zhentong Capsule Assessed By Network Pharmacology Analysis of Adenomyosis Treatment
Du L, Du DH, Chen B, Ding Y, Zhang T, Xiao W
Drug Design, Development and Therapy 2020, 14:697-713
Published Date: 20 February 2020
Colon Targeting of Naringin for Enhanced Cytoprotection Against Indomethacin-Induced Colitis in Rabbits
El Naggar EE, Mohamed EA, Borg TM, El-Sheakh AR, Hamed MF
Drug Design, Development and Therapy 2020, 14:677-696
Published Date: 19 February 2020
Impacts of CYP2C19 Polymorphism and Clopidogrel Dosing on in-Stent Restenosis: A Retrospective Cohort Study in Chinese Patients
Zhang M, Wang J, Zhang Y, Zhang P, Jia Z, Ren M, Jia X, Ma L, Gao M, Hou Y
Drug Design, Development and Therapy 2020, 14:669-676
Published Date: 19 February 2020
Comparison of Pharmacokinetics of a Fixed-Dose Combination of Amlodipine/Losartan/Rosuvastatin with Concomitant Administration of Amlodipine/Losartan and Rosuvastatin in Healthy Volunteers
Yoon DY, Park SI, Jung JA, Kim YI, Jang IJ, Chung JY
Drug Design, Development and Therapy 2020, 14:661-668
Published Date: 19 February 2020
Targeted Therapy for Hepatocellular Carcinoma: Co-Delivery of Sorafenib and Curcumin Using Lactosylated pH-Responsive Nanoparticles
Bian Y, Guo D
Drug Design, Development and Therapy 2020, 14:647-659
Published Date: 18 February 2020
A Comparative Study of Inhaled Nitric Oxide and an Intravenously Administered Nitric Oxide Donor in Acute Pulmonary Hypertension
Stene Hurtsén A, Zorikhin Nilsson I, Dogan EM, Nilsson KF
Drug Design, Development and Therapy 2020, 14:635-645
Published Date: 17 February 2020
Hydrogen Sulfide Protects Against High Glucose-Induced Human Umbilical Vein Endothelial Cell Injury Through Activating PI3K/Akt/eNOS Pathway
Lin F, Yang Y, Wei S, Huang X, Peng Z, Ke X, Zeng Z, Song Y
Drug Design, Development and Therapy 2020, 14:621-633
Published Date: 14 February 2020
Pharmacokinetics and Tolerability of Single and Multiple Intravenous Doses of Cefotetan Disodium in Healthy Chinese Volunteers
Liu J, Zhai Y, Wu L, Wu G, Zheng Y, Hu X, Shentu J
Drug Design, Development and Therapy 2020, 14:613-620
Published Date: 13 February 2020
Silibinin Augments the Antifibrotic Effect of Valsartan Through Inactivation of TGF-β1 Signaling in Kidney
Liu R, Wang Q, Ding Z, Zhang X, Li Y, Zang Y, Zhang G
Drug Design, Development and Therapy 2020, 14:603-611
Published Date: 13 February 2020
Lysosomal Acid Lipase Deficiency: Therapeutic Options
Pastores GM, Hughes DA
Drug Design, Development and Therapy 2020, 14:591-601
Published Date: 11 February 2020
Regulations of miR-183-5p and Snail-Mediated Shikonin-Reduced Epithelial-Mesenchymal Transition in Cervical Cancer Cells
Tang Q, Liu L, Zhang H, Xiao J, Hann SS
Drug Design, Development and Therapy 2020, 14:577-589
Published Date: 11 February 2020
Minoxidil and Its Use in Hair Disorders: A Review [Corrigendum]
Suchonwanit P, Thammarucha S, Leerunyakul K
Drug Design, Development and Therapy 2020, 14:575-576
Published Date: 10 February 2020
Optimization of a Benzothiazole Indolene Scaffold Targeting Bacterial Cell Wall Assembly
Chauhan J, Yu W, Cardinale S, Opperman TJ, MacKerell AD Jr, Fletcher S, de Leeuw EPH
Drug Design, Development and Therapy 2020, 14:567-574
Published Date: 10 February 2020
Focus on Notoginsenoside R1 in Metabolism and Prevention Against Human Diseases
Liu H, Yang J, Yang W, Hu S, Wu Y, Zhao B, Hu H, Du S
Drug Design, Development and Therapy 2020, 14:551-565
Published Date: 7 February 2020
Potential Use of Microbial Surfactant in Microemulsion Drug Delivery System: A Systematic Review
Ohadi M, Shahravan A, Dehghannoudeh N, Eslaminejad T, Banat IM, Dehghannoudeh G
Drug Design, Development and Therapy 2020, 14:541-550
Published Date: 5 February 2020
In silico Analysis, Molecular Docking, Molecular Dynamic, Cloning, Expression and Purification of Chimeric Protein in Colorectal Cancer Treatment [Erratum]
Dana H, Mahmoodi Chalbatani G, Gharagouzloo E, Miri SR, Memari F, Rasoolzadeh R, Zinatizadeh MR, Kheirandish Zarandi P, Marmari V
Drug Design, Development and Therapy 2020, 14:539-540
Published Date: 5 February 2020
Panax Notoginseng Ameliorates Podocyte EMT by Targeting the Wnt/β-Catenin Signaling Pathway in STZ-Induced Diabetic Rats
Xie L, Zhai R, Chen T, Gao C, Xue R, Wang N, Wang J, Xu Y, Gui D
Drug Design, Development and Therapy 2020, 14:527-538
Published Date: 5 February 2020
Hesperetin-5,7,3ʹ-O-Trimethylether Dually Inhibits Phosphodiesterase 3/4 and Methacholine-Induced Airway Hyperresponsiveness in Sensitized and Challenged Mice
Shih CH, Wang WH, Chen CM, Ko WC
Drug Design, Development and Therapy 2020, 14:519-526
Published Date: 4 February 2020
Curcumin Has Anti-Proliferative and Pro-Apoptotic Effects on Tongue Cancer in vitro: A Study with Bioinformatics Analysis and in vitro Experiments
Ma C, Zhuang Z, Su Q, He J, Li H
Drug Design, Development and Therapy 2020, 14:509-518
Published Date: 4 February 2020
Design, Synthesis and Biological Evaluation of New HDAC1 and HDAC2 Inhibitors Endowed with Ligustrazine as a Novel Cap Moiety
Al-Sanea MM, Gotina L, Mohamed MFA, Grace Thomas Parambi D, Gomaa HAM, Mathew B, Youssif BGM, Alharbi KS, Elsayed ZM, Abdelgawad MA, Eldehna WM
Drug Design, Development and Therapy 2020, 14:497-508
Published Date: 4 February 2020
New Isatin–Indole Conjugates: Synthesis, Characterization, and a Plausible Mechanism of Their in vitro Antiproliferative Activity
Al-Wabli RI, Almomen AA, Almutairi MS, Keeton AB, Piazza GA, Attia MI
Drug Design, Development and Therapy 2020, 14:483-495
Published Date: 3 February 2020
Clinical Evidence and Safety Profile of Emicizumab for the Management of Children with Hemophilia A
Le Quellec S
Drug Design, Development and Therapy 2020, 14:469-481
Published Date: 3 February 2020
Metformin Activates the AMPK-mTOR Pathway by Modulating lncRNA TUG1 to Induce Autophagy and Inhibit Atherosclerosis
You G, Long X, Song F, Huang J, Tian M, Xiao Y, Deng S, Wu Q
Drug Design, Development and Therapy 2020, 14:457-468
Published Date: 3 February 2020
Development of a Novel Controlled-Release Tablet of Pregabalin: Formulation Variation and Pharmacokinetics in Dogs and Humans
Kim KH, Lim SH, Shim CR, Park J, Song WH, Kwon MC, Lee JH, Park JS, Choi HG
Drug Design, Development and Therapy 2020, 14:445-456
Published Date: 30 January 2020
Comparative Pharmacokinetics, Bioequivalence and Safety Study of Two Recombinant Human Chorionic Gonadotropin Injections in Healthy Chinese Subjects
Wang J, Yang T, Mei H, Yu X, Peng H, Wang R, Cai Y
Drug Design, Development and Therapy 2020, 14:435-444
Published Date: 29 January 2020
Calycosin Influences the Metabolism of Five Probe Drugs in Rats
Wu M, Lin Y, Wei Y, Du H, Ying X, Tan W, Tang B
Drug Design, Development and Therapy 2020, 14:429-434
Published Date: 29 January 2020
Induction of Autophagy by Baicalin Through the AMPK-mTOR Pathway Protects Human Skin Fibroblasts from Ultraviolet B Radiation-Induced Apoptosis
Zhang JA, Luan C, Huang D, Ju M, Chen K, Gu H
Drug Design, Development and Therapy 2020, 14:417-428
Published Date: 29 January 2020
A New Validated HPLC-MS/MS Method for Quantification and Pharmacokinetic Evaluation of Dovitinib, a Multi-Kinase Inhibitor, in Mouse Plasma
AlRabiah H, Kadi AA, Aljohar HI, Attwa MW, Al-Shakliah NS, Attia SM, Mostafa GAE
Drug Design, Development and Therapy 2020, 14:407-415
Published Date: 28 January 2020
Genipin Induces Autophagy and Suppresses Cell Growth of Oral Squamous Cell Carcinoma via PI3K/AKT/MTOR Pathway
Wei M, Wu Y, Liu H, Xie C
Drug Design, Development and Therapy 2020, 14:395-405
Published Date: 29 January 2020
Reversible Small Molecule Inhibitors of MAO A and MAO B with Anilide Motifs
Hagenow J, Hagenow S, Grau K, Khanfar M, Hefke L, Proschak E, Stark H
Drug Design, Development and Therapy 2020, 14:371-393
Published Date: 28 January 2020
Tetrandrine Suppresses Transient Receptor Potential Cation Channel Protein 6 Overexpression- Induced Podocyte Damage via Blockage of RhoA/ROCK1 Signaling
Yu J, Zhu C, Yin J, Yu D, Wan F, Tang X, Jiang X
Drug Design, Development and Therapy 2020, 14:361-370
Published Date: 28 January 2020
Effect of Fimasartan versus Valsartan and Olmesartan on Office and Ambulatory Blood Pressure in Korean Patients with Mild-to-Moderate Essential Hypertension: A Randomized, Double-Blind, Active Control, Three-Parallel Group, Forced Titration, Multicenter, Phase IV Study (Fimasartan Achieving Systolic Blood Pressure Target (FAST) Study)
Chung WB, Ihm SH, Jang SW, Her SH, Park CS, Lee JM, Chang K, Jeon DS, Yoo KD, Seung KB
Drug Design, Development and Therapy 2020, 14:347-360
Published Date: 23 January 2020
Cardioprotective Effect of Monoammonium Glycyrrhizinate Injection Against Myocardial Ischemic Injury in vivo and in vitro: Involvement of Inhibiting Oxidative Stress and Regulating Ca2+ Homeostasis by L-Type Calcium Channels
Zhao Z, Liu M, Zhang Y, Liang Y, Ma D, Wang H, Ma Z, Guan S, Wu Z, Chu X, Lin Y, Chu L
Drug Design, Development and Therapy 2020, 14:331-346
Published Date: 23 January 2020
In silico Analysis, Molecular Docking, Molecular Dynamic, Cloning, Expression and Purification of Chimeric Protein in Colorectal Cancer Treatment
Dana H, Mahmoodi Chalbatani G, Gharagouzloo E, Miri SR, Memari F, Rasoolzadeh R, Zinatizadeh MR, Kheirandish Zarandi P, Marmari V
Drug Design, Development and Therapy 2020, 14:309-329
Published Date: 23 January 2020
The Antagonist of Retinoic Acid Receptor α, ER-50891 Antagonizes the Inhibitive Effect of All-Trans Retinoic Acid and Rescues Bone Morphogenetic Protein 2-Induced Osteoblastogenic Differentiation
Wang S, Bi W, Liu Y, Cheng J, Sun W, Wu G, Xu X
Drug Design, Development and Therapy 2020, 14:297-308
Published Date: 22 January 2020
Progress in Understanding the Molecular Mechanisms Underlying the Antitumour Effects of Ivermectin
Liu J, Zhang K, Cheng L, Zhu H, Xu T
Drug Design, Development and Therapy 2020, 14:285-296
Published Date: 21 January 2020
Apatinib in Patients with Relapsed or Refractory Diffuse Large B Cell Lymphoma: A Phase II, Open-Label, Single-Arm, Prospective Study
Ma X, Li L, Zhang L, Fu X, Li X, Wang X, Wu J, Sun Z, Zhang X, Feng X, Chang Y, Zhou Z, Nan F, Zhang J, Li Z, Zhang M
Drug Design, Development and Therapy 2020, 14:275-284
Published Date: 22 January 2020
An Updated Systematic Review With Meta-Analysis Of Randomized Trials On Topical Cyclosporin A For Dry-Eye Disease
Tuan HI, Chi SC, Kang YN
Drug Design, Development and Therapy 2020, 14:265-274
Published Date: 17 January 2020
The Impact of Loading Dose on Outcome in Stroke Patients Receiving Low-Dose Tissue Plasminogen Activator Thrombolytic Therapy
Wong YS, Sung SF, Wu CS, Hsu YC, Su YH, Hung LC, Ong CT
Drug Design, Development and Therapy 2020, 14:257-263
Published Date: 17 January 2020
Enhancing Betulinic Acid Dissolution Rate and Improving Antitumor Activity via Nanosuspension Constructed by Anti-Solvent Technique
Li S, Zhang J, Fang Y, Yi J, Lu Z, Chen Y, Guo B
Drug Design, Development and Therapy 2020, 14:243-256
Published Date: 16 January 2020
Electrospun PLA Fibers Containing Metronidazole for Periodontal Disease
Budai-Szűcs M, Léber A, Cui L, Józó M, Vályi P, Burián K, Kirschweng B, Csányi E, Pukánszky B
Drug Design, Development and Therapy 2020, 14:233-242
Published Date: 16 January 2020
KGF Is Delivered to Inflammatory and Induces the Epithelial Hyperplasia in Trinitrobenzene Sulfonic Acid-Induced Ulcerative Colitis Rats
Jia K, Wang Y, Tong X, Wang R
Drug Design, Development and Therapy 2020, 14:217-231
Published Date: 16 January 2020
Discovery of a Novel Benzenesulfonamide Analogue That Inhibits Proliferation and Metastasis Against Ovarian Cancer OVCAR-8 Cells
Jia Y, Li M, Cao Y, Feng W, Li X, Xue W, Shi H
Drug Design, Development and Therapy 2020, 14:207-216
Published Date: 15 January 2020
Baicalin Ameliorates Dexamethasone-Induced Osteoporosis by Regulation of the RANK/RANKL/OPG Signaling Pathway
Zhao Y, Wang HL, Li TT, Yang F, Tzeng CM
Drug Design, Development and Therapy 2020, 14:195-206
Published Date: 15 January 2020
Curcumin Combined with Thalidomide Reduces Expression of STAT3 and Bcl-xL, Leading to Apoptosis in Acute Myeloid Leukemia Cell Lines
Mohammadi Kian M, Salemi M, Bahadoran M, Haghi A, Dashti N, Mohammadi S, Rostami S, Chahardouli B, Babakhani D, Nikbakht M
Drug Design, Development and Therapy 2020, 14:185-194
Published Date: 15 January 2020
Edaravone Ameliorates Renal Warm Ischemia-Reperfusion Injury by Downregulating Endoplasmic Reticulum Stress in a Rat Resuscitation Model
Fu ZY, Wu ZJ, Zheng JH, Li N, Lu JY, Chen MH
Drug Design, Development and Therapy 2020, 14:175-183
Published Date: 15 January 2020
Isoborneol Attenuates Low-Density Lipoprotein Accumulation and Foam Cell Formation in Macrophages
Wang Y, Li Z, Liu B, Wu R, Gong H, Su Z, Zhang S
Drug Design, Development and Therapy 2020, 14:167-173
Published Date: 15 January 2020
Cost-Effectiveness Analysis of Ezetimibe as the Add-on Treatment to Moderate-Dose Rosuvastatin versus High-Dose Rosuvastatin in the Secondary Prevention of Cardiovascular Diseases in China: A Markov Model Analysis
Yang H, Li N, Zhou Y, Xiao Z, Tian H, Hu M, Li S
Drug Design, Development and Therapy 2020, 14:157-165
Published Date: 14 January 2020
Aloin Inhibits the Proliferation and Migration of Gastric Cancer Cells by Regulating NOX2–ROS-Mediated Pro-Survival Signal Pathways
Wang Z, Tang T, Wang S, Cai T, Tao H, Zhang Q, Qi S, Qi Z
Drug Design, Development and Therapy 2020, 14:145-155
Published Date: 14 January 2020
Bergenin Exerts Hepatoprotective Effects by Inhibiting the Release of Inflammatory Factors, Apoptosis and Autophagy via the PPAR-γ Pathway
Xiang S, Chen K, Xu L, Wang T, Guo C
Drug Design, Development and Therapy 2020, 14:129-143
Published Date: 13 January 2020
RGFP966 Suppresses Tumor Growth and Migration Through Inhibition of EGFR Expression in Hepatocellular Carcinoma Cells in vitro
Yu X, Yang F, Jiang H, Fan L
Drug Design, Development and Therapy 2020, 14:121-128
Published Date: 10 January 2020
Metabolic Stability Assessment of Larotrectinib Using Liquid Chromatography Tandem Mass Spectrometry
Attwa MW, Kadi AA, Darwish HW
Drug Design, Development and Therapy 2020, 14:111-119
Published Date: 10 January 2020
Suitability of Amoxicillin–Clavulanic Acid for Administration via Prolonged Infusion
Fawaz S, Dixon B, Barton S, Mohamed A, Nabhani-Gebara S
Drug Design, Development and Therapy 2020, 14:103-109
Published Date: 10 January 2020
In vitro Antifungal Effects of Berberine Against Candida spp. In Planktonic and Biofilm Conditions
Xie Y, Liu X, Zhou P
Drug Design, Development and Therapy 2020, 14:87-101
Published Date: 9 January 2020
Curcumin Attenuates Oxaliplatin-Induced Liver Injury and Oxidative Stress by Activating the Nrf2 Pathway
Lu Y, Wu S, Xiang B, Li L, Lin Y
Drug Design, Development and Therapy 2020, 14:73-85
Published Date: 9 January 2020
Sappanone A Protects Against Myocardial Ischemia Reperfusion Injury by Modulation of Nrf2
Shi X, Tao G, Ji L, Tian G
Drug Design, Development and Therapy 2020, 14:61-71
Published Date: 8 January 2020
Protective Effects of Chlorogenic Acid on Cerebral Ischemia/Reperfusion Injury Rats by Regulating Oxidative Stress-Related Nrf2 Pathway
Liu D, Wang H, Zhang Y, Zhang Z
Drug Design, Development and Therapy 2020, 14:51-60
Published Date: 7 January 2020
Comparison of the Pharmacokinetics, Safety, and Tolerability of the Autoinjector (AI) and Pre-Filled Syringe (PFS) of SB4 in Healthy Subjects
Shin D, Kim Y, Go A, Velinova M
Drug Design, Development and Therapy 2020, 14:43-50
Published Date: 8 January 2020
Engineering of Naproxen Loaded Polymer Hybrid Enteric Microspheres for Modified Release Tablets: Development, Characterization, in silico Modelling and in vivo Evaluation
Hameed HA, Khan S, Shahid M, Ullah R, Bari A, Ali SS, Hussain Z, Sohail M, Khan SU, Htar TT
Drug Design, Development and Therapy 2020, 14:27-41
Published Date: 7 January 2020
NMMHC IIA Inhibition Ameliorates Cerebral Ischemic/Reperfusion-Induced Neuronal Apoptosis Through Caspase-3/ROCK1/MLC Pathway
Wang GY, Wang TZ, Zhang YY, Li F, Yu BY, Kou JP
Drug Design, Development and Therapy 2020, 14:13-25
Published Date: 6 January 2020
Safety, Tolerability, and Pharmacokinetics of Adrenomedullin in Healthy Males: A Randomized, Double-Blind, Phase 1 Clinical Trial
Kita T, Kaji Y, Kitamura K
Drug Design, Development and Therapy 2020, 14:1-11
Published Date: 6 January 2020