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Drug Design, Development and Therapy


Archive: Volume 14, 2020

One-Pot Synthesis of Novel Thiazoles as Potential Anti-Cancer Agents

Sayed AR, Gomha SM, Taher EA, Muhammad ZA, El-Seedi HR, Gaber HM, Ahmed MM

Drug Design, Development and Therapy 2020, 14:1363-1375

Published Date: 3 April 2020

Proniosomal Telmisartan Tablets: Formulation, in vitro Evaluation and in vivo Comparative Pharmacokinetic Study in Rabbits

Teaima MH, Yasser M, El-Nabarawi MA, Helal DA

Drug Design, Development and Therapy 2020, 14:1319-1331

Published Date: 31 March 2020

Leishmania donovani Growth Inhibitors from Pathogen Box Compounds of Medicine for Malaria Venture

Tadele M, Abay SM, Makonnen E, Hailu A

Drug Design, Development and Therapy 2020, 14:1307-1317

Published Date: 31 March 2020

Alginate Suppresses Liver Fibrosis Through the Inhibition of Nuclear Factor-κB Signaling

Xia Z, Ding L, Zheng J, Xu Y, Jin W, Sheng X, Wu J

Drug Design, Development and Therapy 2020, 14:1295-1305

Published Date: 31 March 2020

Diterpene Ginkgolides Exert an Antidepressant Effect Through the NT3-TrkA and Ras-MAPK Pathways

Wang T, Bai S, Wang W, Chen Z, Chen J, Liang Z, Qi X, Shen H, Xie P

Drug Design, Development and Therapy 2020, 14:1279-1294

Published Date: 31 March 2020

Growth Factor Gene-Modified Mesenchymal Stem Cells in Tissue Regeneration

Nie WB, Zhang D, Wang LS

Drug Design, Development and Therapy 2020, 14:1241-1256

Published Date: 26 March 2020

Morusin Ameliorates IL-1β-Induced Chondrocyte Inflammation and Osteoarthritis via NF-κB Signal Pathway

Jia Y, He W, Zhang H, He L, Wang Y, Zhang T, Peng J, Sun P, Qian Y

Drug Design, Development and Therapy 2020, 14:1227-1240

Published Date: 26 March 2020

Comparison of Pharmacokinetics of Aprepitant in Healthy Chinese and Caucasian Subjects

Yang MJ, Xu HR, Li H, Chen WL, Yuan F, Li XN

Drug Design, Development and Therapy 2020, 14:1219-1226

Published Date: 24 March 2020

Miconazole Contributes to NRF2 Activation by Noncanonical P62-KEAP1 Pathway in Bladder Cancer Cells

Tsai TF, Chen PC, Lin YC, Chou KY, Chen HE, Ho CY, Lin JF, Hwang TIS

Drug Design, Development and Therapy 2020, 14:1209-1218

Published Date: 24 March 2020

Paeoniflorin Ameliorates Chronic Hypoxia/SU5416-Induced Pulmonary Arterial Hypertension by Inhibiting Endothelial-to-Mesenchymal Transition

Yu M, Peng L, Liu P, Yang M, Zhou H, Ding Y, Wang J, Huang W, Tan Q, Wang Y, Xie W, Kong H, Wang H

Drug Design, Development and Therapy 2020, 14:1191-1202

Published Date: 19 March 2020

A First-in-Human Dose Finding Study of Camrelizumab in Patients with Advanced or Metastatic Cancer in Australia

Lickliter JD, Gan HK, Voskoboynik M, Arulananda S, Gao B, Nagrial A, Grimison P, Harrison M, Zou J, Zhang L, Luo S, Lahn M, Kallender H, Mannucci A, Somma C, Woods K, Behren A, Fernandez-Penas P, Millward M, Meniawy T

Drug Design, Development and Therapy 2020, 14:1177-1189

Published Date: 18 March 2020

Hyaluronic Acid Capped, Irinotecan and Gene Co-Loaded Lipid-Polymer Hybrid Nanocarrier-Based Combination Therapy Platform for Colorectal Cancer

Wang Z, Zang A, Wei Y, An L, Hong D, Shi Y, Zhang J, Su S, Fang G

Drug Design, Development and Therapy 2020, 14:1095-1105

Published Date: 12 March 2020

Review on the Structures and Activities of Transthyretin Amyloidogenesis Inhibitors

Guo X, Liu Z, Zheng Y, Li Y, Li L, Liu H, Chen Z, Wu L

Drug Design, Development and Therapy 2020, 14:1057-1081

Published Date: 10 March 2020

KLF6 Induces Apoptosis in Human Lens Epithelial Cells Through the ATF4-ATF3-CHOP Axis

Tian F, Zhao J, Bu S, Teng H, Yang J, Zhang X, Li X, Dong L

Drug Design, Development and Therapy 2020, 14:1041-1055

Published Date: 9 March 2020

In silico Design and Synthesis of Tetrahydropyrimidinones and Tetrahydropyrimidinethiones as Potential Thymidylate Kinase Inhibitors Exerting Anti-TB Activity Against Mycobacterium tuberculosis

Venugopala KN, Tratrat C, Pillay M, Chandrashekharappa S, Al-Attraqchi OHA, Aldhubiab BE, Attimarad M, Alwassil OI, Nair AB, Sreeharsha N, Venugopala R, Morsy MA, Haroun M, Kumalo HM, Odhav B, Mlisana K

Drug Design, Development and Therapy 2020, 14:1027-1039

Published Date: 9 March 2020

Characterization and Evaluation of Antioxidant Activity of Aloe schelpei Reynolds

Teka T, Kassahun H

Drug Design, Development and Therapy 2020, 14:1003-1008

Published Date: 5 March 2020

Bisdemethoxycurcumin Inhibits Hepatocellular Carcinoma Proliferation Through Akt Inactivation via CYLD-Mediated Deubiquitination

Qiu C, Liu K, Zhang S, Gao S, Chen W, Li D, Huang Y

Drug Design, Development and Therapy 2020, 14:993-1001

Published Date: 5 March 2020

Study on the Formation of Antihypertensive Twin Drugs by Caffeic Acid and Ferulic Acid with Telmisartan

Li P, Peng Y, Ma Q, Li Z, Zhang X

Drug Design, Development and Therapy 2020, 14:977-992

Published Date: 5 March 2020

Perindopril in Breast Milk and Determination of Breastfed Infant Exposure: A Prospective Observational Study

Leggett C, Lwin EMP, Ritchie U, Song Y, Gerber JP, Turner S, Hague WM, Stark M, Upton R, Garg S

Drug Design, Development and Therapy 2020, 14:961-967

Published Date: 2 March 2020

Finasteride and Its Potential for the Treatment of Female Pattern Hair Loss: Evidence to Date

Iamsumang W, Leerunyakul K, Suchonwanit P

Drug Design, Development and Therapy 2020, 14:951-959

Published Date: 2 March 2020

The Traditional Chinese Medicine Compound, GRS, Alleviates Blood–Brain Barrier Dysfunction

Zhang Y, Hu Y, Li M, Wang J, Guo G, Li F, Yu B, Kou J

Drug Design, Development and Therapy 2020, 14:933-947

Published Date: 28 February 2020

Oxymatrine Liposomes for Intervertebral Disc Treatment: Formulation, in vitro and vivo Assessments

Wang H, Ding Y, Zhang W, Wei K, Pei Y, Zou C, Zhang C, Ding J, Fang H, Tan S

Drug Design, Development and Therapy 2020, 14:921-931

Published Date: 28 February 2020

Pleiotropic Anticancer Properties of Scorpion Venom Peptides: Rhopalurus princeps Venom as an Anticancer Agent

Mikaelian AG, Traboulay E, Zhang XM, Yeritsyan E, Pedersen PL, Ko YH, Matalka KZ

Drug Design, Development and Therapy 2020, 14:881-893

Published Date: 27 February 2020

The Advantages of Levodopa-Carbidopa Intestinal Gel for Patients with Advanced Parkinson’s Disease: A Systematic Review

Zhang XR, Jiang ZY, Zhang ZR, Chen HJ, Wu K, He JC, Xie CL

Drug Design, Development and Therapy 2020, 14:845-854

Published Date: 26 February 2020

Metalloprotoporphyrin Inhibition of HCV NS3-4A Protease: Structure–Activity Relationships

Hu K, Zhu Z, Mathahs MM, Tran H, Bommer J, Testa CA, Schmidt WN

Drug Design, Development and Therapy 2020, 14:757-771

Published Date: 24 February 2020

NVP-BSK805, an Inhibitor of JAK2 Kinase, Significantly Enhances the Radiosensitivity of Esophageal Squamous Cell Carcinoma in vitro and in vivo

Hua Y, Wang W, Zheng X, Yang L, Wu H, Hu Z, Li Y, Yue J, Jiang Z, Zhang X, Hou Q, Wu S

Drug Design, Development and Therapy 2020, 14:745-755

Published Date: 24 February 2020

Synthesis, Characterization, and Pharmacodynamics Study of Enrofloxacin Mesylate

Pei L, Yang W, Fu J, Liu M, Zhang T, Li D, Huang R, Zhang L, Peng G, Shu G, Yuan Z, Lin J, Zhang W, Zhong Z, Zhao L, Fu H

Drug Design, Development and Therapy 2020, 14:715-730

Published Date: 24 February 2020

Anti-Inflammatory Activity of Sanjie Zhentong Capsule Assessed By Network Pharmacology Analysis of Adenomyosis Treatment 

Du L, Du DH, Chen B, Ding Y, Zhang T, Xiao W

Drug Design, Development and Therapy 2020, 14:697-713

Published Date: 20 February 2020

Colon Targeting of Naringin for Enhanced Cytoprotection Against Indomethacin-Induced Colitis in Rabbits

El Naggar EE, Mohamed EA, Borg TM, El-Sheakh AR, Hamed MF

Drug Design, Development and Therapy 2020, 14:677-696

Published Date: 19 February 2020

Impacts of CYP2C19 Polymorphism and Clopidogrel Dosing on in-Stent Restenosis: A Retrospective Cohort Study in Chinese Patients

Zhang M, Wang J, Zhang Y, Zhang P, Jia Z, Ren M, Jia X, Ma L, Gao M, Hou Y

Drug Design, Development and Therapy 2020, 14:669-676

Published Date: 19 February 2020

A Comparative Study of Inhaled Nitric Oxide and an Intravenously Administered Nitric Oxide Donor in Acute Pulmonary Hypertension

Stene Hurtsén A, Zorikhin Nilsson I, Dogan EM, Nilsson KF

Drug Design, Development and Therapy 2020, 14:635-645

Published Date: 17 February 2020

Hydrogen Sulfide Protects Against High Glucose-Induced Human Umbilical Vein Endothelial Cell Injury Through Activating PI3K/Akt/eNOS Pathway

Lin F, Yang Y, Wei S, Huang X, Peng Z, Ke X, Zeng Z, Song Y

Drug Design, Development and Therapy 2020, 14:621-633

Published Date: 14 February 2020

Pharmacokinetics and Tolerability of Single and Multiple Intravenous Doses of Cefotetan Disodium in Healthy Chinese Volunteers

Liu J, Zhai Y, Wu L, Wu G, Zheng Y, Hu X, Shentu J

Drug Design, Development and Therapy 2020, 14:613-620

Published Date: 13 February 2020

Silibinin Augments the Antifibrotic Effect of Valsartan Through Inactivation of TGF-β1 Signaling in Kidney

Liu R, Wang Q, Ding Z, Zhang X, Li Y, Zang Y, Zhang G

Drug Design, Development and Therapy 2020, 14:603-611

Published Date: 13 February 2020

Lysosomal Acid Lipase Deficiency: Therapeutic Options

Pastores GM, Hughes DA

Drug Design, Development and Therapy 2020, 14:591-601

Published Date: 11 February 2020

Regulations of miR-183-5p and Snail-Mediated Shikonin-Reduced Epithelial-Mesenchymal Transition in Cervical Cancer Cells

Tang Q, Liu L, Zhang H, Xiao J, Hann SS

Drug Design, Development and Therapy 2020, 14:577-589

Published Date: 11 February 2020

Minoxidil and Its Use in Hair Disorders: A Review [Corrigendum]

Suchonwanit P, Thammarucha S, Leerunyakul K

Drug Design, Development and Therapy 2020, 14:575-576

Published Date: 10 February 2020

Optimization of a Benzothiazole Indolene Scaffold Targeting Bacterial Cell Wall Assembly

Chauhan J, Yu W, Cardinale S, Opperman TJ, MacKerell AD Jr, Fletcher S, de Leeuw EPH

Drug Design, Development and Therapy 2020, 14:567-574

Published Date: 10 February 2020

Focus on Notoginsenoside R1 in Metabolism and Prevention Against Human Diseases

Liu H, Yang J, Yang W, Hu S, Wu Y, Zhao B, Hu H, Du S

Drug Design, Development and Therapy 2020, 14:551-565

Published Date: 7 February 2020

Potential Use of Microbial Surfactant in Microemulsion Drug Delivery System: A Systematic Review

Ohadi M, Shahravan A, Dehghannoudeh N, Eslaminejad T, Banat IM, Dehghannoudeh G

Drug Design, Development and Therapy 2020, 14:541-550

Published Date: 5 February 2020

In silico Analysis, Molecular Docking, Molecular Dynamic, Cloning, Expression and Purification of Chimeric Protein in Colorectal Cancer Treatment [Erratum]

Dana H, Mahmoodi Chalbatani G, Gharagouzloo E, Miri SR, Memari F, Rasoolzadeh R, Zinatizadeh MR, Kheirandish Zarandi P, Marmari V

Drug Design, Development and Therapy 2020, 14:539-540

Published Date: 5 February 2020

Panax Notoginseng Ameliorates Podocyte EMT by Targeting the Wnt/β-Catenin Signaling Pathway in STZ-Induced Diabetic Rats

Xie L, Zhai R, Chen T, Gao C, Xue R, Wang N, Wang J, Xu Y, Gui D

Drug Design, Development and Therapy 2020, 14:527-538

Published Date: 5 February 2020

Design, Synthesis and Biological Evaluation of New HDAC1 and HDAC2 Inhibitors Endowed with Ligustrazine as a Novel Cap Moiety

Al-Sanea MM, Gotina L, Mohamed MFA, Grace Thomas Parambi D, Gomaa HAM, Mathew B, Youssif BGM, Alharbi KS, Elsayed ZM, Abdelgawad MA, Eldehna WM

Drug Design, Development and Therapy 2020, 14:497-508

Published Date: 4 February 2020

New Isatin–Indole Conjugates: Synthesis, Characterization, and a Plausible Mechanism of Their in vitro Antiproliferative Activity

Al-Wabli RI, Almomen AA, Almutairi MS, Keeton AB, Piazza GA, Attia MI

Drug Design, Development and Therapy 2020, 14:483-495

Published Date: 3 February 2020

Metformin Activates the AMPK-mTOR Pathway by Modulating lncRNA TUG1 to Induce Autophagy and Inhibit Atherosclerosis

You G, Long X, Song F, Huang J, Tian M, Xiao Y, Deng S, Wu Q

Drug Design, Development and Therapy 2020, 14:457-468

Published Date: 3 February 2020

Development of a Novel Controlled-Release Tablet of Pregabalin: Formulation Variation and Pharmacokinetics in Dogs and Humans

Kim KH, Lim SH, Shim CR, Park J, Song WH, Kwon MC, Lee JH, Park JS, Choi HG

Drug Design, Development and Therapy 2020, 14:445-456

Published Date: 30 January 2020

Calycosin Influences the Metabolism of Five Probe Drugs in Rats

Wu M, Lin Y, Wei Y, Du H, Ying X, Tan W, Tang B

Drug Design, Development and Therapy 2020, 14:429-434

Published Date: 29 January 2020

A New Validated HPLC-MS/MS Method for Quantification and Pharmacokinetic Evaluation of Dovitinib, a Multi-Kinase Inhibitor, in Mouse Plasma

AlRabiah H, Kadi AA, Aljohar HI, Attwa MW, Al-Shakliah NS, Attia SM, Mostafa GAE

Drug Design, Development and Therapy 2020, 14:407-415

Published Date: 28 January 2020

Reversible Small Molecule Inhibitors of MAO A and MAO B with Anilide Motifs

Hagenow J, Hagenow S, Grau K, Khanfar M, Hefke L, Proschak E, Stark H

Drug Design, Development and Therapy 2020, 14:371-393

Published Date: 28 January 2020

In silico Analysis, Molecular Docking, Molecular Dynamic, Cloning, Expression and Purification of Chimeric Protein in Colorectal Cancer Treatment

Dana H, Mahmoodi Chalbatani G, Gharagouzloo E, Miri SR, Memari F, Rasoolzadeh R, Zinatizadeh MR, Kheirandish Zarandi P, Marmari V

Drug Design, Development and Therapy 2020, 14:309-329

Published Date: 23 January 2020

Progress in Understanding the Molecular Mechanisms Underlying the Antitumour Effects of Ivermectin

Liu J, Zhang K, Cheng L, Zhu H, Xu T

Drug Design, Development and Therapy 2020, 14:285-296

Published Date: 21 January 2020

Apatinib in Patients with Relapsed or Refractory Diffuse Large B Cell Lymphoma: A Phase II, Open-Label, Single-Arm, Prospective Study

Ma X, Li L, Zhang L, Fu X, Li X, Wang X, Wu J, Sun Z, Zhang X, Feng X, Chang Y, Zhou Z, Nan F, Zhang J, Li Z, Zhang M

Drug Design, Development and Therapy 2020, 14:275-284

Published Date: 22 January 2020

The Impact of Loading Dose on Outcome in Stroke Patients Receiving Low-Dose Tissue Plasminogen Activator Thrombolytic Therapy

Wong YS, Sung SF, Wu CS, Hsu YC, Su YH, Hung LC, Ong CT

Drug Design, Development and Therapy 2020, 14:257-263

Published Date: 17 January 2020

Enhancing Betulinic Acid Dissolution Rate and Improving Antitumor Activity via Nanosuspension Constructed by Anti-Solvent Technique

Li S, Zhang J, Fang Y, Yi J, Lu Z, Chen Y, Guo B

Drug Design, Development and Therapy 2020, 14:243-256

Published Date: 16 January 2020

Electrospun PLA Fibers Containing Metronidazole for Periodontal Disease

Budai-Szűcs M, Léber A, Cui L, Józó M, Vályi P, Burián K, Kirschweng B, Csányi E, Pukánszky B

Drug Design, Development and Therapy 2020, 14:233-242

Published Date: 16 January 2020

Discovery of a Novel Benzenesulfonamide Analogue That Inhibits Proliferation and Metastasis Against Ovarian Cancer OVCAR-8 Cells

Jia Y, Li M, Cao Y, Feng W, Li X, Xue W, Shi H

Drug Design, Development and Therapy 2020, 14:207-216

Published Date: 15 January 2020

Baicalin Ameliorates Dexamethasone-Induced Osteoporosis by Regulation of the RANK/RANKL/OPG Signaling Pathway

Zhao Y, Wang HL, Li TT, Yang F, Tzeng CM

Drug Design, Development and Therapy 2020, 14:195-206

Published Date: 15 January 2020

Curcumin Combined with Thalidomide Reduces Expression of STAT3 and Bcl-xL, Leading to Apoptosis in Acute Myeloid Leukemia Cell Lines

Mohammadi Kian M, Salemi M, Bahadoran M, Haghi A, Dashti N, Mohammadi S, Rostami S, Chahardouli B, Babakhani D, Nikbakht M

Drug Design, Development and Therapy 2020, 14:185-194

Published Date: 15 January 2020

Isoborneol Attenuates Low-Density Lipoprotein Accumulation and Foam Cell Formation in Macrophages

Wang Y, Li Z, Liu B, Wu R, Gong H, Su Z, Zhang S

Drug Design, Development and Therapy 2020, 14:167-173

Published Date: 15 January 2020

Aloin Inhibits the Proliferation and Migration of Gastric Cancer Cells by Regulating NOX2–ROS-Mediated Pro-Survival Signal Pathways

Wang Z, Tang T, Wang S, Cai T, Tao H, Zhang Q, Qi S, Qi Z

Drug Design, Development and Therapy 2020, 14:145-155

Published Date: 14 January 2020

Metabolic Stability Assessment of Larotrectinib Using Liquid Chromatography Tandem Mass Spectrometry

Attwa MW, Kadi AA, Darwish HW

Drug Design, Development and Therapy 2020, 14:111-119

Published Date: 10 January 2020

Suitability of Amoxicillin–Clavulanic Acid for Administration via Prolonged Infusion

Fawaz S, Dixon B, Barton S, Mohamed A, Nabhani-Gebara S

Drug Design, Development and Therapy 2020, 14:103-109

Published Date: 10 January 2020

Curcumin Attenuates Oxaliplatin-Induced Liver Injury and Oxidative Stress by Activating the Nrf2 Pathway

Lu Y, Wu S, Xiang B, Li L, Lin Y

Drug Design, Development and Therapy 2020, 14:73-85

Published Date: 9 January 2020

Sappanone A Protects Against Myocardial Ischemia Reperfusion Injury by Modulation of Nrf2

Shi X, Tao G, Ji L, Tian G

Drug Design, Development and Therapy 2020, 14:61-71

Published Date: 8 January 2020

Engineering of Naproxen Loaded Polymer Hybrid Enteric Microspheres for Modified Release Tablets: Development, Characterization, in silico Modelling and in vivo Evaluation

Hameed HA, Khan S, Shahid M, Ullah R, Bari A, Ali SS, Hussain Z, Sohail M, Khan SU, Htar TT

Drug Design, Development and Therapy 2020, 14:27-41

Published Date: 7 January 2020

NMMHC IIA Inhibition Ameliorates Cerebral Ischemic/Reperfusion-Induced Neuronal Apoptosis Through Caspase-3/ROCK1/MLC Pathway

Wang GY, Wang TZ, Zhang YY, Li F, Yu BY, Kou JP

Drug Design, Development and Therapy 2020, 14:13-25

Published Date: 6 January 2020