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International Journal of Chronic Obstructive Pulmonary Disease
ISSN: 1178-2005
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Archive: Volume 16, 2021
Spiperone Stimulates Regeneration in Pulmonary Endothelium Damaged by Cigarette Smoke and Lipopolysaccharide
Skurikhin E, Pershina O, Zhukova M, Widera D, Pan E, Pakhomova A, Krupin V, Ermakova N, Skurikhina V, Sandrikina L, Morozov S, Kubatiev A, Dygai A
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:3575-3591
Published Date: 30 December 2021
Autologous Infusion of Bone Marrow and Mesenchymal Stromal Cells in Patients with Chronic Obstructive Pulmonary Disease: Phase I Randomized Clinical Trial

Squassoni SD, Sekiya EJ, Fiss E, Lapa MS, Cayetano DS, Nascimento F, Alves A, Machado NC, Escaramboni B, Lívero FAR, Malagutti-Ferreira MJ, Soares MR, dos Santos Figueiredo FW, Kramer BKN, Zago PMJJ, Ribeiro-Paes JT
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:3561-3574
Published Date: 29 December 2021
Eosinopenia Predicting Long-term Mortality in Hospitalized Acute Exacerbation of COPD Patients with Community-acquired Pneumonia—A Retrospective Analysis
Mao Y, Qian Y, Sun X, Li N, Huang H
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:3551-3559
Published Date: 30 December 2021
Impact of Sex on Circulating Leukocytes Composition in COPD Patients
Troianova N, Mariotti B, Micheletti V, Calzetti F, Donini M, Salvagno G, Ferrari M, Crisafulli E, Bazzoni F
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:3539-3550
Published Date: 25 December 2021
Pulmonary Rehabilitation Programmes Within Three Days of Hospitalization for Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis
Zhang D, Zhang H, Li X, Lei S, Wang L, Guo W, Li J
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:3525-3538
Published Date: 24 December 2021
Serum Creatinine/Cystatin C Ratio Associated with Cross-Sectional Area of Erector Spinae Muscles and Pulmonary Function in Patients with Chronic Obstructive Pulmonary Disease
Nishiki K, Nojiri M, Kato R, Shinomiya S, Oikawa T, Ishizaki T, Toga H, Mizuno S
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:3513-3524
Published Date: 24 December 2021
Effect of Nocturnal Oxygen on Blood Pressure Response to Altitude Exposure in COPD – Data from a Randomized Placebo-Controlled Cross-Over Trial
Meszaros M, Latshang TD, Aeschbacher SS, Huber F, Flueck D, Lichtblau M, Ulrich S, Hasler ED, Scheiwiller PM, Reinhard L, Ulrich S, Bloch KE, Furian M, Schwarz EI
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:3503-3512
Published Date: 24 December 2021
Terms and Definitions Used to Describe Recurrence, Treatment Failure and Recovery of Acute Exacerbations of COPD: A Systematic Review of Observational Studies
Meeraus WH, DeBarmore BM, Mullerova H, Fahy WA, Benson VS
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:3487-3502
Published Date: 24 December 2021
Lung Function and Health Status in Individuals with Severe Alpha-1-Antitrypsin Deficiency at the Age of 42
Schramm GR, Mostafavi B, Piitulainen E, Wollmer P, Tanash HA
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:3477-3485
Published Date: 23 December 2021
Asymptomatic Patients with Airflow Limitation are at Higher Risk of Postoperative Pulmonary Complications After Lung Surgeries: An Ambispective Cohort Study
Wang Y, Yin X, Xie M, Wang Q, Wang W, Yi W, Yu J
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:3465-3475
Published Date: 22 December 2021
Integrated Disease Management for Chronic Obstructive Pulmonary Disease in Primary Care, from the Controlled Trial to Clinical Program: A Cohort Study
Hussey AJ, Wing K, Ferrone M, Licskai CJ
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:3449-3464
Published Date: 22 December 2021

Association of Total Airway Count on Computed Tomography with Pulmonary Function Decline in Early-Stage COPD: A Population-Based Prospective Cohort Study
Wu F, Jiang C, Zhou Y, Zheng Y, Tian H, Li H, Deng Z, Zhao N, Chen H, Ran P
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:3437-3448
Published Date: 18 December 2021
COPD and Anticoagulation Therapy: Time for a New Approach?
Petris OR, Cojocaru E, Fildan AP, Cojocaru C
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:3429-3436
Published Date: 18 December 2021
Associations of Clinical Characteristics and Intestinal Flora Imbalance in Stable Chronic Obstructive Pulmonary Disease (COPD) Patients and the Construction of an Early Warning Model
Zeng X, Yang H, Yang Y, Gu X, Ma X, Zhu T
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:3417-3428
Published Date: 18 December 2021
Performance and Clinical Utility of Various Chronic Obstructive Pulmonary Disease Case-Finding Tools
Chen CZ, Sheu CC, Cheng SL, Wang HC, Lin MC, Hsu WH, Lee KY, Perng DW, Lin HI, Lin MS, Lin SH, Tsai JR, Wang CC, Wang CY, Yang TM, Liu CL, Wang TY, Lin CH
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:3405-3415
Published Date: 18 December 2021
Self-Efficacy Intervention Programs in Patients with Chronic Obstructive Pulmonary Disease: Narrative Review
Yi QF, Yang GL, Yan J
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:3397-3403
Published Date: 18 December 2021

Anxiety and Depression in Patients with Chronic Obstructive Pulmonary Disease in China: Results from the China Pulmonary Health [CPH] Study
Huang K, Huang K, Xu J, Yang L, Zhao J, Zhang X, Bai C, Kang J, Ran P, Shen H, Wen F, Chen Y, Sun T, Shan G, Lin Y, Wu S, Yang T, Wang C
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:3387-3396
Published Date: 17 December 2021
Chinese Medical Injections for Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Network Meta-analysis
Hu H, Ji Z, Qiang X, Liu S, Sheng X, Chen Z, Liu F, Wang H, Zhang J
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:3363-3386
Published Date: 17 December 2021

Hypermethylation of the Nrf2 Promoter Induces Ferroptosis by Inhibiting the Nrf2-GPX4 Axis in COPD
Zhang Z, Fu C, Liu J, Sai X, Qin C, Di T, Yang Y, Wu Y, Bian T
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:3347-3362
Published Date: 14 December 2021

The Current Status of Vaccine Uptake and the Impact of COVID-19 on Intention to Vaccination in Patients with COPD in Beijing
Song Z, Liu X, Xiang P, Lin Y, Dai L, Guo Y, Liao J, Chen Y, Liang Y, Sun Y
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:3337-3346
Published Date: 8 December 2021
Xuanbai Chengqi Decoction Ameliorates Pulmonary Inflammation via Reshaping Gut Microbiota and Rectifying Th17/Treg Imbalance in a Murine Model of Chronic Obstructive Pulmonary Disease

Wang Y, Li N, Li Q, Liu Z, Li Y, Kong J, Dong R, Ge D, Li J, Peng G
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:3317-3335
Published Date: 7 December 2021
Interaction of Acute Respiratory Failure and Acute Kidney Injury on in-Hospital Mortality of Patients with Acute Exacerbation COPD
Chen D, Jiang L, Li J, Tan Y, Ma M, Cao C, Zhao J, Wan X
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:3309-3316
Published Date: 7 December 2021
Factors Associated with Reduction of Sedentary Time Following Tiotropium/Olodaterol Therapy in Treatment-Naïve Chronic Obstructive Pulmonary Disease
Takahashi K, Tashiro H, Tajiri R, Takamori A, Uchida M, Kato G, Kurihara Y, Sadamatsu H, Kinoshita T, Yoshida M, Kawaguchi A, Kimura S, Sueoka-Aragane N, Kawayama T
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:3297-3307
Published Date: 6 December 2021
PM2.5 Induces Airway Remodeling in Chronic Obstructive Pulmonary Diseases via the Wnt5a/β-Catenin Pathway
Zou W, Wang X, Sun R, Hu J, Ye D, Bai G, Liu S, Hong W, Guo M, Ran P
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:3285-3295
Published Date: 3 December 2021
A Randomized Double-Blind Placebo-Control Feasibility Trial of Immunoglobulin Treatment for Prevention of Recurrent Acute Exacerbations of COPD
Cowan J, Mulpuru S, Abdallah SJ, Chopra A, Purssell A, McGuinty M, Alvarez GG, Giulivi A, Corrales-Medina V, MacFadden D, Boyle L, Hasimja D, Thavorn K, Mallick R, Aaron SD, Cameron DW
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:3275-3284
Published Date: 3 December 2021
Feasibility of RESP-FIT: Technology-Enhanced Self-Management Intervention for Adults with COPD
Miller S, Teufel II R, Nichols M, Davenport P, Mueller M, Silverman E, Madisetti M, Pittman M, Kelechi T, Strange C
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:3263-3273
Published Date: 3 December 2021
Impact of Chronic Obstructive Pulmonary Disease on the Mortality of Patients with Small Cell Lung Cancer
Liao KM, Hung CM, Shu CC, Lee HS, Wei YF
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:3255-3262
Published Date: 1 December 2021
Annual Body Weight Change and Prognosis in Chronic Obstructive Pulmonary Disease
Abe Y, Suzuki M, Shima H, Shiraishi Y, Tanabe N, Sato S, Shimizu K, Kimura H, Makita H, Hirai T, Konno S, Nishimura M
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:3243-3253
Published Date: 30 November 2021
Adapting Inhaled Medication Practice in COPD and Asthma to Avoid Funding the Tobacco Industry [Corrigendum]
Capstick TGD, Hopkinson NS
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:3239-3241
Published Date: 30 November 2021

Comparison of Risk of Pneumonia Caused by Fluticasone Propionate versus Budesonide in Chronic Obstructive Pulmonary Disease: A Nationwide Retrospective Cohort Study
Choi JH, Jeong KB, Park YH, Yu I, Lee SJ, Lee MK, Kim SH, Lee WY, Yong SJ, Lee JH
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:3229-3237
Published Date: 25 November 2021

Focus on Early COPD: Definition and Early Lung Development
Yang W, Li F, Li C, Meng J, Wang Y
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:3217-3228
Published Date: 25 November 2021
Advanced Dental Cleaning is Associated with Reduced Risk of COPD Exacerbations – A Randomized Controlled Trial
Sundh J, Tanash H, Arian R, Neves-Guimaraes A, Broberg K, Lindved G, Kern T, Zych K, Nielsen HB, Halling A, Ohlsson B, Jönsson D
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:3203-3215
Published Date: 25 November 2021
Aerobic Exercise Alleviates Inflammation, Oxidative Stress, and Apoptosis in Mice with Chronic Obstructive Pulmonary Disease [Corrigendum]
Wang X, Wang Z, Tang D
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:3201-3202
Published Date: 24 November 2021
Lower Prevalence of Osteoporosis in Patients with COPD Taking Anti-Inflammatory Compounds for the Treatment of Diabetes: Results from COSYCONET
Kahnert K, Jörres RA, Lucke T, Trudzinski FC, Mertsch P, Bickert C, Ficker JH, Behr J, Bals R, Watz H, Welte T, Vogelmeier CF, Alter P
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:3189-3199
Published Date: 24 November 2021
Characterizing Gas Exchange Physiology in Healthy Young Electronic-Cigarette Users with Hyperpolarized 129Xe MRI: A Pilot Study
He M, Qing K, Tustison NJ, Beaulac Z, King TW, Huff TB, Paige M, Earasi K, Nunoo-Asare R, Struchen S, Burdick M, Zhang Z, Ropp A, Miller GW, Patrie JT, Mata JF, Mugler JP 3rd, Shim YM
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:3183-3187
Published Date: 23 November 2021

Treatable Traits in COPD – A Proposed Approach
Cardoso J, Ferreira AJ, Guimarães M, Oliveira AS, Simão P, Sucena M
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:3167-3182
Published Date: 18 November 2021
Hospital Variation in Non-Invasive Ventilation Use for Acute Respiratory Failure Due to COPD Exacerbation
Fortis S, Gao Y, O’Shea AMJ, Beck B, Kaboli P, Vaughan Sarrazin M
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:3157-3166
Published Date: 17 November 2021

Effects of Nutritional Interventions in Individuals with Chronic Obstructive Lung Disease: A Systematic Review of Randomized Controlled Trials
Furulund E, Bemanian M, Berggren N, Madebo T, Rivedal SH, Lid TG, Fadnes LT
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:3145-3156
Published Date: 17 November 2021
Economic Impact of Low Adherence to COPD Management Guidelines in Spain
Miravitlles M, Solé A, Aguilar H, Ampudia A, Costa-Samarra J, Mallén-Alberdi M, Nieves D
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:3131-3143
Published Date: 16 November 2021
Identifying miRNA Modules and Related Pathways of Chronic Obstructive Pulmonary Disease Associated Emphysema by Weighted Gene Co-Expression Network Analysis
An J, Yang T, Dong J, Liao Z, Wan C, Shen Y, Chen L
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:3119-3130
Published Date: 15 November 2021


Economic Evaluation of Umeclidinium/Vilanterol versus Umeclidinium or Salmeterol in Symptomatic Non-Exacerbating Patients with COPD from a UK Perspective Using the GALAXY Model
Shukla S, Shah D, Martin A, Risebrough NA, Kendall R, Vogelmeier CF, Boucot I, Tombs L, Bjermer L, Jones PW, Kerwin E, Compton C, Maltais F, Lipson DA, Ismaila AS
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:3105-3118
Published Date: 13 November 2021
Lung Health in the Solomon Islands: A Mixed Methods Study
Di Michiel J, Gawthorne J, Shivam A, Maruno K, Cohn S, Lemon C, Liu Z, Byrne A
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:3093-3103
Published Date: 12 November 2021
Characteristics and Prevalence of Early Chronic Obstructive Pulmonary Disease in a Middle-Aged Population: Results from a Nationwide-Representative Sample
Kim T, Kim J, Kim JH
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:3083-3091
Published Date: 12 November 2021
Small Airways Response to Bronchodilators in Adults with Asthma or COPD: A Systematic Review
Almeshari MA, Alobaidi NY, Sapey E, Usmani O, Stockley RA, Stockley JA
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:3065-3082
Published Date: 11 November 2021
Responsivity and Reproducibility of Sputum Inflammatory Biomarkers During COPD Exacerbation and Stable Phases – A Pilot Study
Ditz B, Kistemaker LEM, van den Berge M, Vonk JM, Gosens R, Kerstjens HAM
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:3055-3064
Published Date: 10 November 2021

Reference Equations for Assessing the Physical Activity of Japanese Patients with Chronic Obstructive Pulmonary Disease
Minakata Y, Sasaki S, Azuma Y, Kawabe K, Ono H
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:3041-3053
Published Date: 9 November 2021
Immune Characteristics Analysis and Transcriptional Regulation Prediction Based on Gene Signatures of Chronic Obstructive Pulmonary Disease
Yu H, Guo W, Liu Y, Wang Y
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:3027-3039
Published Date: 5 November 2021
Nine-Year Follow-Up of Interleukin 6 in Chronic Obstructive Pulmonary Disease – Complementary Results from Previous Studies
Prudente R, Ferrari R, Mesquita C, Machado L, Franco E, Godoy I, Tanni S
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:3019-3026
Published Date: 3 November 2021
Chronic Obstructive Pulmonary Disease in Women: A Biologically Focused Review with a Systematic Search Strategy [Corrigendum]
Han MK
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:3017-3018
Published Date: 4 November 2021
Overcoming Therapeutic Inertia to Reduce the Risk of COPD Exacerbations: Four Action Points for Healthcare Professionals
Singh D, Holmes S, Adams C, Bafadhel M, Hurst JR
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:3009-3016
Published Date: 1 November 2021

Clinical Impact of the Bronchiectasis with Chronic Bronchitis Symptoms in COPD: Analysis of a Longitudinal Cohort
Kim EK, Kim MA, Lee JS, Lee SM, Lim S, Park J, Kim JH, Oh YM, Lee SD, Lee SH, Lee JH
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:2997-3008
Published Date: 1 November 2021

Alpha 1 Antitrypsin Therapy in Patients with Alpha 1 Antitrypsin Deficiency: Perspectives from a Registry Study and Practical Considerations for Self-Administration During the COVID-19 Pandemic
Herth FJF, Sandhaus RA, Turner AM, Sucena M, Welte T, Greulich T
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:2983-2996
Published Date: 1 November 2021
Trend of Mortality and Years of Life Lost Due to Chronic Obstructive Pulmonary Disease in China and Its Provinces, 2005–2020
Liu W, Wang W, Liu J, Liu Y, Meng S, Wang F, Long Z, Qi J, You J, Lin L, Wang L, Zhou M, Yin P
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:2973-2981
Published Date: 29 October 2021
Anemia Severely Reduces Health-Related Quality of Life in COPD Patients Receiving Long-Term Home Non-Invasive Ventilation
Wollsching-Strobel M, Schwarz SB, Mathes T, Majorski DS, Heidari P, Kroppen D, Magnet FS, Windisch W
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:2963-2971
Published Date: 28 October 2021
Chronic Obstructive Pulmonary Disease and Associated Factors in Arba Minch Health and Demographic Surveillance Site, 2020
Agedew E, Boda B, Kanko T, Estifanos W, Shibiru T
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:2953-2962
Published Date: 28 October 2021
Interleukin-6 is a Strong Predictor of the Frequency of COPD Exacerbation Within 1 Year
Huang H, Huang X, Zeng K, Deng F, Lin C, Huang W
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:2945-2951
Published Date: 28 October 2021
Risk of Coronary Heart Disease in People with Chronic Obstructive Pulmonary Disease: A Meta-Analysis
Wang JJ
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:2939-2944
Published Date: 27 October 2021

Pulmonary Dysfunction Augmenting Bacterial Aerosols in Leather Tanneries of Punjab, Pakistan

Sarwar F, Alam K, Chow CW, Saeed M, Malik RN
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:2925-2937
Published Date: 27 October 2021

Adapting Inhaled Medication Practice in COPD and Asthma to Avoid Funding the Tobacco Industry
Capstick TGD, Hopkinson NS
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:2917-2923
Published Date: 23 October 2021
Nursing Outcomes and Risk Factors of Patients with Chronic Obstructive Pulmonary Disease After Discharge
Chai YH, Yang H, Huang GP, Wu T, Dong Y
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:2911-2916
Published Date: 21 October 2021
Clinical Features and Outcomes of Acute Exacerbation in Chronic Obstructive Pulmonary Disease Patients with Pulmonary Heart Disease: A Multicenter Observational Study
You L, Niu H, Huang K, Dong F, Yang T, Wang C
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:2901-2910
Published Date: 22 October 2021
Significance of Stenotrophomonas maltophilia When Detected in Sputum of Ambulatory Patients with COPD
Soumagne T, Levesque F, Milot J, Godbout K, Lacasse Y, Maltais F
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:2895-2900
Published Date: 20 October 2021
The Value of Impulse Oscillometric Parameters and Quantitative HRCT Parameters in Differentiating Asthma–COPD Overlap from COPD
Lu D, Chen L, Fan C, Zeng W, Fan H, Wu X, Yu H
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:2883-2894
Published Date: 19 October 2021
Effectiveness of Nationwide COPD Pay-for-Performance Program on COPD Exacerbations in Taiwan

Cheng SL, Li YR, Huang N, Yu CJ, Wang HC, Lin MC, Chiu KC, Hsu WH, Chen CZ, Sheu CC, Perng DW, Lin SH, Yang TM, Lin CB, Kor CT, Lin CH
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:2869-2881
Published Date: 18 October 2021
The Cumulative Effect of Gene–Gene Interactions Between GSTM1, CHRNA3, CHRNA5 and SOD3 Gene Polymorphisms Combined with Smoking on COPD Risk
Ganbold C, Jamiyansuren J, Tumurbaatar A, Bayarmaa A, Enebish T, Dashtseren I, Jav S
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:2857-2868
Published Date: 18 October 2021
GSK-3β Inhibitors Attenuate the PM2.5-Induced Inflammatory Response in Bronchial Epithelial Cells
Zou W, Ye D, Liu S, Hu J, Zhu T, He F, Ran P
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:2845-2856
Published Date: 14 October 2021

Clinical Characteristics, Treatment Patterns and Economic Burden of COPD in Kyrgyzstan: A FRESH AIR Study
Tabyshova A, Estebesova B, Beishenbekova A, Sooronbaev T, Brakema EA, Chavannes NH, Postma MJ, van Boven JFM
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:2833-2843
Published Date: 11 October 2021
GLIPR1 Protects Against Cigarette Smoke-Induced Airway Inflammation via PLAU/EGFR Signaling
Peng W, Wu Y, Zhang G, Zhu W, Chang M, Rouzi A, Jiang W, Tong L, Wang Q, Liu J, Song Y, Li H, Li K, Zhou J
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:2817-2832
Published Date: 8 October 2021
Effect of Endobronchial Coils on Exercise Tolerance and Lung Functions in Patients with Severe Emphysema – A Retrospective Cohort Study of 48 Patients
Pertzov B, Soliman M, Shostak Y, Heching M, Rosengarten D, Izbicki G, Kramer MR
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:2809-2815
Published Date: 8 October 2021
Quantifying the Economic Impact of Delayed Multiple-Inhaler Triple Therapy Initiation in Patients with COPD: A Retrospective Cohort Study of Linked Electronic Medical Record and Hospital Administrative Data in England
Sansbury LB, Wood RP, Anley GA, Nam Y, Ismaila AS
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:2795-2808
Published Date: 8 October 2021
Human Adipose-Derived Mesenchymal Stem Cells Ameliorate Elastase-Induced Emphysema in Mice by Mesenchymal–Epithelial Transition
Fujioka N, Kitabatake M, Ouji-Sageshima N, Ibaraki T, Kumamoto M, Fujita Y, Hontsu S, Yamauchi M, Yoshikawa M, Muro S, Ito T
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:2783-2793
Published Date: 8 October 2021

Predictors of 30- and 90-Day COPD Exacerbation Readmission: A Prospective Cohort Study
Alqahtani JS, Aldabayan YS, Aldhahir AM, Al Rajeh AM, Mandal S, Hurst JR
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:2769-2781
Published Date: 7 October 2021
Continuity of Care Assessment Within a Vertically Integrated Care Management Organization Before and After COPD-Related Exacerbations
Fuoco MJ, Mularski RA, Wu B, Moretz C, McBurnie MA, Stanford RH, Crawford P, Gratie D, Salas B
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:2755-2767
Published Date: 7 October 2021
MiR-361-5p/abca1 and MiR-196-5p/arhgef12 Axis Involved in γ-Sitosterol Inducing Dual Anti-Proliferative Effects on Bronchial Epithelial Cells of Chronic Obstructive Pulmonary Disease
Shen HF, Liu Y, Qu PP, Tang Y, Li BB, Cheng GL
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:2741-2753
Published Date: 5 October 2021
Association of the Tight Junction Protein Claudin-4 with Lung Function and Exacerbations in Chronic Obstructive Pulmonary Disease
Park S, Lee PH, Baek AR, Park JS, Lee J, Park SW, Kim DJ, Jang AS
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:2735-2740
Published Date: 5 October 2021
Risk of COPD Exacerbations Associated with Statins versus Fibrates: A New User, Active Comparison, and High-Dimensional Propensity Score Matched Cohort Study
Sun SH, Chang CH, Zhan ZW, Chang WH, Chen YA, Dong YH
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:2721-2733
Published Date: 1 October 2021

The Effects of Inhaled Airway Directed Pharmacotherapy on Decline in Lung Function Parameters Among Indigenous Australian Adults With and Without Underlying Airway Disease
Heraganahally SS, Ponneri TR, Howarth TP, Ben Saad H
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:2707-2720
Published Date: 29 September 2021
Adherence to Inhaled Therapy in Patients with COPD Associated to Pneumoconiosis
Peng Y, Duan J, Li X, Zeng Y, Zhou Z, Deng M, Ouyang R, Chen Y, Cai S, Chen P
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:2697-2706
Published Date: 27 September 2021


Treating COPD Patients with Inhaled Medications in the Era of COVID-19 and Beyond: Options and Rationales for Patients at Home


Ari A, Blain K, Soubra S, Hanania NA
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:2687-2695
Published Date: 28 September 2021

Effect of Omega-3 Fatty Acids on Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Yu H, Su X, Lei T, Zhang C, Zhang M, Wang Y, Zhu L, Liu J
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:2677-2686
Published Date: 23 September 2021

Prevalence and Characteristics of Individuals with Preserved Ratio Impaired Spirometry (PRISm) and/or Impaired Lung Function in Japan: The OCEAN Study
Kaise T, Sakihara E, Tamaki K, Miyata H, Hirahara N, Kirichek O, Tawara R, Akiyama S, Katsumata M, Haruya M, Ishii T, Simard EP, Miller BE, Tal-Singer R
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:2665-2675
Published Date: 23 September 2021
Transcriptomics Analysis Identifies the Presence of Upregulated Ribosomal Housekeeping Genes in the Alveolar Macrophages of Patients with Smoking-Induced Chronic Obstructive Pulmonary Disease
Han L, Wang J, Ji XB, Wang ZY, Wang Y, Zhang LY, Li HP, Zhang ZM, Li QY
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:2653-2664
Published Date: 22 September 2021
Impact of Lung Function and Exacerbations on Health-Related Quality of Life in COPD Patients Within One Year: Real-World Analysis Based on Claims Data
Stöber A, Lutter JI, Schwarzkopf L, Kirsch F, Schramm A, Vogelmeier CF, Leidl R
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:2637-2651
Published Date: 21 September 2021
The rs74794265 SNP of the SREK1 Gene is Associated with COPD in Kashi, China
Abudureheman Z, Li L, Zhong X, Xu J, Gong H, Yilamujiang S, Ren J, Xie C, Zheng A, Tuerxun D, Abudukadeer A, Aini P, Xu A, Zou X
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:2631-2636
Published Date: 16 September 2021

Estimated Prevalence and Number of PiMZ Genotypes of Alpha-1 Antitrypsin in Seventy-Four Countries Worldwide
Martinez-González C, Blanco I, Diego I, Bueno P, Miravitlles M
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:2617-2630
Published Date: 17 September 2021
Nucleotide-Oligomerizing Domain-1 Activation Exaggerates Cigarette Smoke-Induced Chronic Obstructive Pulmonary-Like Disease in Mice
Han G, Li M, Du J, Chen Y, Xu C
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:2605-2615
Published Date: 16 September 2021
Healthcare, Medication Utilization and Outcomes of Patients with COPD by GOLD Classification in England
Sansbury LB, Rothnie KJ, Bains C, Compton C, Anley G, Ismaila AS
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:2591-2604
Published Date: 15 September 2021
Detection of Small Airway Dysfunction in Asymptomatic Smokers with Preserved Spirometry: The Value of the Impulse Oscillometry System
Pisi R, Aiello M, Frizzelli A, Calzetta L, Marchi L, Bertorelli G, Pisi G, Chetta A
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:2585-2590
Published Date: 14 September 2021
Lung Features in Individuals with Biomass Smoke Exposure Characterized by CT Scan and Changes in Pulmonary Function
Chen J, Jiang C, Zheng Y, Zhao D, Wu F, Zhao Z, Zhao J, Li Q, Li B, Peng G, Zhou Y, Ran P
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:2575-2584
Published Date: 10 September 2021
Increased Serum Soluble Interleukin-2 Receptor Associated with Severity of Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Zhang Y, Ren L, Sun J, Han F, Guo X
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:2561-2573
Published Date: 7 September 2021

Identifying a Heart Rate Recovery Criterion After a 6-Minute Walk Test in COPD
Zhao D, Abbasi A, Casaburi R, Adami A, Tiller NB, Yuan W, Yee C, Jendzjowsky NG, MacDonald DM, Kunisaki KM, Stringer WW, Porszasz J, Make BJ, Bowler RP, Rossiter HB
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:2545-2560
Published Date: 4 September 2021

High 24-Hour Respiratory Symptoms and Low Physical Activity in the Stable COPD Romanian Cohort of SPACE Study


Mihaltan F, Rajnoveanu RM, Arghir OC, Alecu S, Postolache PA
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:2533-2544
Published Date: 6 September 2021
Predicting Respiratory Complications Following Lobectomy Using Quantitative CT Measures of Emphysema
Kitazawa S, Wijesinghe AI, Maki N, Yanagihara T, Saeki Y, Kobayashi N, Kikuchi S, Goto Y, Ichimura H, Sato Y
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:2523-2531
Published Date: 4 September 2021
Association of Systemic Inflammation with Depressive Symptoms in Individuals with COPD
Strollo HC, Nouraie SM, Hoth KF, Riley CM, Karoleski C, Zhang Y, Hanania NA, Bowler RP, Bon J, Sciurba FC
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:2515-2522
Published Date: 3 September 2021
The Inflammatory Response Induced by RELMβ Upregulates IL-8 and IL-1β Expression in Bronchial Epithelial Cells in COPD
Che L, Yu C, Chen G, Lin J, Xie Z, Xia T, Luo W, Cai X, Liu S
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:2503-2513
Published Date: 2 September 2021
Letter to Editor Regarding the OCEAN Study [Letter]
Yawn BP, Make B, Mannino D, Martinez FJ, Han MK
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:2501-2502
Published Date: 2 September 2021
Bronchodilator Response in Patients with COPD, Asthma-COPD-Overlap (ACO) and Asthma, Evaluated by Plethysmographic and Spirometric z-Score Target Parameters
Kraemer R, Smith HJ, Gardin F, Barandun J, Minder S, Kern L, Brutsche MH
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:2487-2500
Published Date: 1 September 2021
Characterization Associated with the Frequent Severe Exacerbator Phenotype in COPD Patients
Wu YK, Su WL, Yang MC, Chen SY, Wu CW, Lan CC
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:2475-2485
Published Date: 30 August 2021

Clinical Predictors of High Blood Eosinophils in Chronic Obstructive Pulmonary Disease
Yang M, Yang T, Li X, Li D, Liao Z, Shen Y, Xu D, Chen L, Wen F
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:2467-2474
Published Date: 28 August 2021


TRONARTO: A Randomized, Placebo-Controlled Study of Tiotropium/Olodaterol Delivered via Soft Mist Inhaler in COPD Patients Stratified by Peak Inspiratory Flow

Mahler DA, Ludwig-Sengpiel A, Ferguson GT, de la Hoz A, Ritz J, Shaikh A, Watz H
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:2455-2465
Published Date: 28 August 2021

Clinical and Radiological Features of COPD Patients Living at ≥3000 m Above Sea Level in the Tibet Plateau
Liang Y, Yangzom D, Tsokyi L, Ning Y, Su B, Luo S, Ma Cuo B, ChuTso M, Ding Y, Chen Y, Sun Y
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:2445-2454
Published Date: 26 August 2021
National Epidemiological Case–Control Study of Pharmacological Smoking Cessation Treatment in Danish Patients with Chronic Obstructive Pulmonary Disease
Andelius DK, Hilberg O, Ibsen R, Løkke A
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:2433-2443
Published Date: 24 August 2021
Effects of Empirical Glucocorticoid Use on Severe Acute Exacerbation of COPD During Hospitalization
Wu L, Lan N, Yang X
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:2419-2431
Published Date: 24 August 2021

COPD Exacerbation History and Impact on Future Exacerbations – 8-Year Retrospective Observational Database Cohort Study from Germany
Vogelmeier CF, Diesing J, Kossack N, Pignot M, Friedrich FW
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:2407-2417
Published Date: 24 August 2021

Beta-Blockers in High-Risk Outpatients with Chronic Obstructive Pulmonary Disease are Associated with All-Cause Mortality – The STATUETTE Cohort Study
Damkjær M, Suppli Ulrik C, Godtfredsen N, Håkansson KEJ
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:2397-2406
Published Date: 24 August 2021

Statins in High-Risk Chronic Obstructive Pulmonary Disease Outpatients: No Impact on Time to First Exacerbation and All-Cause Mortality – The STATUETTE Cohort Study [Corrigendum]
Damkjær M, Håkansson K, Kallemose T, Ulrik CS, Godtfredsen N
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:2393-2395
Published Date: 19 August 2021
Associations of Medication Regimen Complexity with COPD Medication Adherence and Control
Federman AD, O'Conor R, Wolf MS, Wisnivesky JP
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:2385-2392
Published Date: 19 August 2021
RETRACTED ARTICLE: Effect of Doxofylline on Reducing the Inflammatory Response in Mechanically Ventilated Rats with Chronic Obstructive Pulmonary Disease
Liu CY, Wu JH, Chen ZY, Zhang Y, Huang CL, Lin AM, Xu XT, Gao XH
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:2375-2383
Published Date: 16 August 2021

Inhaled Dual Phosphodiesterase 3/4 Inhibitors for the Treatment of Patients with COPD: A Short Review
Martin C, Burgel PR, Roche N
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:2363-2373
Published Date: 16 August 2021
Identification of Metabolism-Associated Molecular Subtypes of Chronic Obstructive Pulmonary Disease
Hu Y, Cheng X, Qiu Z, Chen X
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:2351-2362
Published Date: 14 August 2021
The Influence of Pulmonary Rehabilitation and Counselling on Perceptions of Physical Activity in Individuals with COPD – A Qualitative Study
Scheermesser M, Reicherzer L, Beyer S, Gisi D, Rezek S, Hess T, Wirz M, Rausch Osthoff AK
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:2337-2350
Published Date: 14 August 2021


Role of a Digital Clinical Decision–Support System in General Practitioners’ Management of COPD in Norway


Vijayakumar VK, Mustafa T, Nore BK, Garatun-Tjeldstø KY, Næss Ø, Johansen OE, Aarli BB
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:2327-2336
Published Date: 13 August 2021

Mortality from COVID-19 in Patients with COPD: A US Study in the N3C Data Enclave
Meza D, Khuder B, Bailey JI, Rosenberg SR, Kalhan R, Reyfman PA
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:2323-2326
Published Date: 13 August 2021


CONQUEST Quality Standards: For the Collaboration on Quality Improvement Initiative for Achieving Excellence in Standards of COPD Care
Pullen R, Miravitlles M, Sharma A, Singh D, Martinez F, Hurst JR, Alves L, Dransfield M, Chen R, Muro S, Winders T, Blango C, Muellerova H, Trudo F, Dorinsky P, Alacqua M, Morris T, Carter V, Couper A, Jones R, Kostikas K, Murray R, Price DB
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:2301-2322
Published Date: 12 August 2021
Identifying Appropriate Delivery of and Referral to Pulmonary Rehabilitation in Uganda: A Survey Study of People Living with Chronic Respiratory Disease and Health Care Workers
Katagira W, Jones AV, Orme MW, Yusuf ZK, Ndagire P, Nanyonga J, Kasiita R, Kasolo JN, Miah RB, Steiner MC, Jones R, Barton A, Kirenga B, Singh SJ
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:2291-2299
Published Date: 10 August 2021
Relationship Between Endogenous Hydrogen Sulfide and Pulmonary Vascular Indexes on High-Resolution Computed Tomography in Patients with Chronic Obstructive Pulmonary Disease
Liao YX, Wang XH, Bai Y, Lin F, Li MX, Mi WJ, Sun WL, Chen YH
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:2279-2289
Published Date: 10 August 2021
The Neutrophil/Lymphocyte Ratio Could Predict Noninvasive Mechanical Ventilation Failure in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Retrospective Observational Study
Sun W, Luo Z, Jin J, Cao Z, Ma Y
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:2267-2277
Published Date: 5 August 2021
Employment Status, Readmission and Mortality After Acute Exacerbation of COPD
Jacobsen PA, Kragholm KH, Torp-Pedersen C, Janssen DJA, Spruit MA, Weinreich UM
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:2257-2265
Published Date: 5 August 2021

Impact of Caregiving Burden on Quality of Life of Caregivers of COPD Patients: The Chain Mediating Role of Social Support and Negative Coping Styles
Yi M, Jiang D, Jia Y, Xu W, Wang H, Li Y, Zhang Z, Wang J, Chen O
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:2245-2255
Published Date: 4 August 2021
Lung Deposition and Inspiratory Flow Rate in Patients with Chronic Obstructive Pulmonary Disease Using Different Inhalation Devices: A Systematic Literature Review and Expert Opinion [Corrigendum]
Baloira A, Abad A, Fuster A, García Rivero JL, García-Sidro P, Márquez-Martín E, Palop M, Soler N, Velasco JL, González-Torralba F
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:2243-2244
Published Date: 3 August 2021

Leukocyte Function in COPD: Clinical Relevance and Potential for Drug Therapy
Baker JR, Donnelly LE
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:2227-2242
Published Date: 30 July 2021

Current Practices in Home Mechanical Ventilation for Chronic Obstructive Pulmonary Disease: A Real-Life Cross-Sectional Multicentric Study
Ribeiro C, Vieira AL, Pamplona P, Drummond M, Seabra B, Ferreira D, Liberato H, Carreiro A, Vicente I, Castro L, Costa P, Carriço F, Martin T, Cravo J, Teixeira N, Grafino M, Conde S, Windisch W, Nunes R
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:2217-2226
Published Date: 29 July 2021
Sputum Protein Biomarkers in Airway Diseases: A Pilot Study
Dasgupta A, Chakraborty R, Saha B, Suri H, Singh P, Raj A, Taneja B, Dash D, Sengupta S, Agrawal A
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:2203-2215
Published Date: 28 July 2021

Narrative Analysis of the Impact of COVID-19 on Patients with Chronic Obstructive Pulmonary Disease, Their Caregivers, and Healthcare Professionals in Italy
Volpato E, Centanni S, Banfi P, D'Antonio S, Peterle E, Bugliaro F, Grattagliano I, Piraino A, Cavalieri L, Pennisi A, Danesi G, Santoiemma L, Marini MG
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:2181-2201
Published Date: 24 July 2021

Sputum Gene Expression Reveals Dysregulation of Mast Cells and Basophils in Eosinophilic COPD
Winter NA, Gibson PG, McDonald VM, Fricker M
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:2165-2179
Published Date: 21 July 2021
Serum Human Epididymal Protein 4 is Associated with Depressive Symptoms in Patients with Chronic Obstructive Pulmonary Disease [Retraction]
Shu Y, Wang W
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:2163-2164
Published Date: 21 July 2021
Burden of Disease Among Exacerbating Patients with COPD Treated with Triple Therapy in Spain
Alcázar-Navarrete B, García-Rio F, Sánchez G, Mariscal E, García A, Cuesta M, Uría E, Miravitlles M
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:2149-2161
Published Date: 21 July 2021
Clinical Evolution and Quality of Life in Clinically Based COPD Chronic Bronchitic and Emphysematous Phenotypes: Results from the 1-Year Follow-Up of the STORICO Italian Observational Study
Blasi F, Antonelli Incalzi R, Canonica GW, Schino P, Cuttitta G, Zullo A, Ori A, Scichilone N
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:2133-2148
Published Date: 21 July 2021
Effects of Ambient Temperature on Acute Exacerbations of Chronic Obstructive Pulmonary Disease: Results from a Time-Series Analysis of 143318 Hospitalizations [Corrigendum]
Zhang Y, Liu X, Kong D, Fu J, Liu Y, Zhao Y, Lian H, Zhao X, Yang J, Fan Z
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:2129-2131
Published Date: 19 July 2021

Inhaled Corticosteroid Therapy in Bronchiectasis is Associated with All-Cause Mortality: A Prospective Cohort Study
Håkansson KEJ, Fjaellegaard K, Browatzki A, Dönmez Sin M, Ulrik CS
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:2119-2127
Published Date: 16 July 2021
Circ-RBMS1 Knockdown Alleviates CSE-Induced Apoptosis, Inflammation and Oxidative Stress via Up-Regulating FBXO11 Through miR-197-3p in 16HBE Cells
Qiao D, Hu C, Li Q, Fan J
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:2105-2118
Published Date: 16 July 2021

Adherence to an eHealth Self-Management Intervention for Patients with Both COPD and Heart Failure: Results of a Pilot Study
Sloots J, Bakker M, van der Palen J, Eijsvogel M, van der Valk P, Linssen G, van Ommeren C, Grinovero M, Tabak M, Effing T, Lenferink A
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:2089-2103
Published Date: 15 July 2021


The Reliability and Validity of the Brief ICF Core Set in Patients with Chronic Obstructive Pulmonary Disease


Zhang Y, Meng X, Shen Y, Xie J, Yu X, Wang Q, Wang L
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:2077-2087
Published Date: 15 July 2021

Step-Up and Step-Down Treatment Approaches for COPD: A Holistic View of Progressive Therapies
López-Campos JL, Carrasco Hernández L, Ruiz-Duque B, Reinoso-Arija R, Caballero-Eraso C
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:2065-2076
Published Date: 12 July 2021
Effects of Atmospheric Fine Particulate Matter and Its Carrier Microbes on Pulmonary Microecology in Patients with COPD
Che C, Sun X, Wu Y, Ma L, Hu Y, Yang W, Qi H, Zhou Y
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:2049-2063
Published Date: 12 July 2021
Validity of the Handheld Expiratory Flowmeter for COPD Screening in the Primary Care Setting of China
Chen S, Li X, Wang Z, Zhou Y, Zhao D, Zhao Z, Liu S, Ran P
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:2039-2047
Published Date: 8 July 2021

Rehabilitation Effects of Acupuncture on the Diaphragm Dysfunction in Chronic Obstructive Pulmonary Disease: A Systematic Review
Liu Q, Duan H, Lian A, Zhuang M, Zhao X, Liu X
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:2023-2037
Published Date: 7 July 2021

The Relationship Between Anxiety, Depression and Treatment Adherence in Chronic Obstructive Pulmonary Disease: A Systematic Review
Volpato E, Toniolo S, Pagnini F, Banfi P
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:2001-2021
Published Date: 6 July 2021
Intramuscular and Intermuscular Abdominal Fat Infiltration in COPD: A Propensity Score Matched Study
Jeon YJ, Han S, Park GM, Lee TY, Park SE, Lee H, Kang BJ
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:1989-1999
Published Date: 5 July 2021


Long-Term Benefits of Adding a Pedometer to Pulmonary Rehabilitation for COPD: The Randomized Controlled STAR Trial
Geidl W, Carl J, Schuler M, Mino E, Lehbert N, Wittmann M, Pfeifer K, Schultz K
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:1977-1988
Published Date: 2 July 2021
Correlation Between 2D Strain and Classic Echocardiographic Indices in the Diagnosis of Right Ventricular Dysfunction in COPD
Masson Silva JB, Tannus Silva DGS, Furtado RG, da Silva Júnior CG, Araújo FA, Costa SDA, Marra da Madeira Freitas E, Rassi DDC, Rabahi MF, Rassi S
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:1967-1976
Published Date: 28 June 2021
Two-Stage Bronchoscopic Endobronchial Valve Treatment Can Lead to Progressive Lung Volume Reduction and May Decrease Pneumothorax Risk
Egenod T, Tricard J, Fumat R, Simonneau Y, Favard F, Guillot MS, Collot S, Dupuis M, Melloni B, Vergnenegre A, Guibert N, Dusselier M
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:1957-1965
Published Date: 28 June 2021

Dual Bronchodilator Therapy as First-Line Treatment in Maintenance-Naïve Patients with Symptomatic COPD: A Pre-Specified Analysis of the EMAX Trial
Bjermer L, Boucot IH, Maltais F, Kerwin EM, Naya IP, Tombs L, Jones PW, Compton C, Lipson DA, Vogelmeier CF
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:1939-1956
Published Date: 28 June 2021

Effect of Age on Efficacy and Safety of Fluticasone Furoate/Vilanterol (FF/VI), Umeclidinium (UMEC), and UMEC + FF/VI in Patients with Chronic Obstructive Pulmonary Disease: Analyses of Five Randomized Clinical Trials
Hanania NA, Caveney S, Soule T, Tombs L, Lettis S, Crim C, Mannino DM, Patel H, Boucot IH
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:1925-1938
Published Date: 24 June 2021
Prevalence and Associated Factors of Suboptimal Daily Peak Inspiratory Flow and Technique Misuse of Dry Powder Inhalers in Outpatients with Stable Chronic Airway Diseases
Ding N, Zhang W, Wang Z, Bai C, He Q, Dong Y, Feng X, Zhang J, Gao S
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:1913-1924
Published Date: 23 June 2021
Clinical Audit on Chronic Obstructive Pulmonary Disease (COPD) Management in Primary Care: A Quality Improvement Project from Hong Kong
Chen XRC, Fu SN, Leung WK, Ng SWC, Kwan WYW, Wong TK, Chan PF, Wong MYM, Ko WKW, Liang J, Hui MTE, Li YC, Luk W, Chao VKD
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:1901-1911
Published Date: 23 June 2021

Validation of COPDPredict™: Unique Combination of Remote Monitoring and Exacerbation Prediction to Support Preventative Management of COPD Exacerbations
Patel N, Kinmond K, Jones P, Birks P, Spiteri MA
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:1887-1899
Published Date: 21 June 2021

Combined Pulmonary Fibrosis Emphysema: Role of Cigarette Smoking and Pulmonary Hypertension in a Rural Cohort
Sangani R, Ghio A, Culp S, Patel Z, Sharma S
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:1873-1885
Published Date: 21 June 2021

Reliability and Validity of the Japanese Version of the Barthel Index Dyspnea Among Patients with Respiratory Diseases
Yamaguchi T, Yamamoto A, Oki Y, Sakai H, Misu S, Iwata Y, Kaneko M, Sawada K, Oki Y, Mitani Y, Ono K, Ishikawa A
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:1863-1871
Published Date: 21 June 2021
Sex Differences in the Incidence and Outcomes of COPD Patients Hospitalized with Ischemic Stroke in Spain: A Population-Based Observational Study
de Miguel-Díez J, López-de-Andrés A, Jiménez-García R, Hernández-Barrera V, Jiménez-Trujillo I, Ji Z, de Miguel-Yanes JM, López-Herranz M
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:1851-1862
Published Date: 18 June 2021

A Real-World Analysis of Treatment Patterns and Clinical Characteristics Among Patients with COPD Who Initiated Multiple-Inhaler Triple Therapy in New Zealand
Xu X, Milea D, Navarro Rojas AA, Braganza A, Holbrook T, Marett B, Young R, Scott RJ, Gribben B
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:1835-1850
Published Date: 18 June 2021
A Novel Model-Based Questionnaire Based on Low-Dose CT Screening Data for Chronic Obstructive Pulmonary Disease Diagnosis in Shimane, Japan
Tanino A, Kawamura T, Hamaguchi M, Tanino R, Nakao M, Hotta T, Tsubata Y, Hamaguchi S, Isobe T
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:1823-1833
Published Date: 18 June 2021


A Prospective Cohort Study to Assess Obstructive Respiratory Disease Phenotypes and Endotypes in Japan: The TRAIT Study Design
Hizawa N, Fukunaga K, Sugiura H, Nakano Y, Kato M, Sugiyama Y, Hanazawa T, Kaise T, Tal-Singer R, Jones PW, Barnes N, Compton C, Ishii T
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:1813-1822
Published Date: 18 June 2021
Clinical Features and Antimicrobial Susceptibility of Pseudomonas aeruginosa and Acinetobacter baumannii Complex Isolates in Intensive Care Patients with Chronic Obstructive Pulmonary Disease and Community-Acquired Pneumonia in Taiwan
Chang KY, Wu PC, Lee CH, Lee YC, Chen HC, Huang WC, Wu MF
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:1801-1811
Published Date: 17 June 2021

Update on Asthma–COPD Overlap (ACO): A Narrative Review
Mekov E, Nuñez A, Sin DD, Ichinose M, Rhee CK, Maselli DJ, Coté A, Suppli Ulrik C, Maltais F, Anzueto A, Miravitlles M
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:1783-1799
Published Date: 17 June 2021

Utility of Self-Administered Questionnaires for Identifying Individuals at Risk of COPD in Japan: The OCEAN (Okinawa COPD casE finding AssessmeNt) Study
Tamaki K, Sakihara E, Miyata H, Hirahara N, Kirichek O, Tawara R, Akiyama S, Katsumata M, Haruya M, Ishii T, Simard EP, Miller BE, Tal-Singer R, Kaise T
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:1771-1782
Published Date: 17 June 2021


Mepolizumab for Eosinophil-Associated COPD: Analysis of METREX and METREO


Pavord ID, Chapman KR, Bafadhel M, Sciurba FC, Bradford ES, Schweiker Harris S, Mayer B, Rubin DB, Yancey SW, Paggiaro P
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:1755-1770
Published Date: 16 June 2021
Predicting Future Health Risk in COPD: Differential Impact of Disease-Specific and Multi-Morbidity-Based Risk Stratification
Groves D, Karsanji U, Evans RA, Greening N, Singh SJ, Quint JK, Whittaker H, Richardson M, Barrett J, Sutch SP, Steiner MC
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:1741-1754
Published Date: 16 June 2021
Understanding the Influences of COPD Patient’s Capability on the Uptake of Pulmonary Rehabilitation in the UK Through an Inclusive Design Approach
Liu Y, Dickerson T, Early F, Fuld J, Jiang C, Clarkson PJ
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:1717-1740
Published Date: 16 June 2021

GOLD 2021 Strategy Report: Implications for Asthma–COPD Overlap
Roman-Rodriguez M, Kaplan A
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:1709-1715
Published Date: 14 June 2021

Atypical Pathogen Distribution in Chinese Hospitalized AECOPD Patients: A Multicenter Cross-Sectional Study
Feng C, Xu M, Kang J, Wen F, Chen Y, Zhang J, Xiao W, Zhang Z, Yang L, Huo J, Cao J, Zhao L, Xia S, Yin Y, Wang W
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:1699-1708
Published Date: 9 June 2021


Development and Validation of a Healthcare Utilization-Based Algorithm to Identify Acute Exacerbations of Chronic Obstructive Pulmonary Disease
Mapel DW, Roberts MH, Sama S, Bobbili PJ, Cheng WY, Duh MS, Nguyen C, Thompson-Leduc P, Van Dyke MK, Rothnie KJ, Sundaresan D, Certa JM, Whiting TS, Brown JL, Roblin DW
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:1687-1698
Published Date: 9 June 2021

Factors Influencing the Length of Hospital Stay Among Patients with Chronic Obstructive Pulmonary Disease (COPD) in Macao Population: A Retrospective Study of Inpatient Health Record
Li M, Cheng K, Ku K, Li J, Hu H, Ung COL
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:1677-1685
Published Date: 9 June 2021
Histone Deacetylase 2 Suppresses Skeletal Muscle Atrophy and Senescence via NF-κB Signaling Pathway in Cigarette Smoke-Induced Mice with Emphysema
Li C, Deng Z, Zheng G, Xie T, Wei X, Huo Z, Bai J
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:1661-1675
Published Date: 4 June 2021

Stigma Experiences in People with Chronic Obstructive Pulmonary Disease: An Integrative Review
Woo S, Zhou W, Larson JL
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:1647-1659
Published Date: 4 June 2021
Nemiralisib in Patients with an Acute Exacerbation of COPD: Placebo-Controlled, Dose-Ranging Study
Fahy WA, Homayoun-Valiani F, Cahn A, Robertson J, Templeton A, Meeraus WH, Wilson R, Lowings M, Marotti M, West SL, Tabberer M, Hessel EM
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:1637-1646
Published Date: 3 June 2021
Exploring PI3Kδ Molecular Pathways in Stable COPD and Following an Acute Exacerbation, Two Randomized Controlled Trials
Begg M, Hamblin JN, Jarvis E, Bradley G, Mark S, Michalovich D, Lennon M, Wajdner HE, Amour A, Wilson R, Saunders K, Tanaka R, Arai S, Tang T, Van Holsbeke C, De Backer J, Vos W, Titlestad IL, FitzGerald JM, Killian K, Bourbeau J, Poirier C, Maltais F, Cahn A, Hessel EM
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:1621-1636
Published Date: 3 June 2021
An Inhaled PI3Kδ Inhibitor Improves Recovery in Acutely Exacerbating COPD Patients: A Randomized Trial
Cahn A, Hamblin JN, Robertson J, Begg M, Jarvis E, Wilson R, Dear G, Leemereise C, Cui Y, Mizuma M, Montembault M, Van Holsbeke C, Vos W, De Backer W, De Backer J, Hessel EM
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:1607-1619
Published Date: 3 June 2021
The Association with COPD Readmission Rate and Access to Medical Institutions in Elderly Patients
Kim TW, Choi ES, Kim WJ, Jo HS
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:1599-1606
Published Date: 3 June 2021


How to Assess Breathlessness in Chronic Obstructive Pulmonary Disease
Lewthwaite H, Jensen D, Ekström M
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:1581-1598
Published Date: 3 June 2021

Feasibility of a 6-Month Home-Based Fall Prevention Exercise Program in Older Adults with COPD
Beauchamp MK, Ellerton C, Kirkwood R, Brooks D, Richardson J, Goldstein RS, Pugsley S, Hatzoglou D
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:1569-1579
Published Date: 3 June 2021

A Real World Study to Assess the Effectiveness of Switching to Once Daily Closed Triple Therapy from Mono/Dual Combination or Open Triple Therapy in Patients with Chronic Obstructive Pulmonary Disease
Huang WC, Chen CY, Liao WC, Wu BR, Chen WC, Tu CY, Chen CH, Cheng WC
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:1555-1568
Published Date: 3 June 2021

Characterization of COPD Admissions During the First COVID-19 Outbreak
Cosio BG, Shafiek H, Toledo-Pons N, Iglesias A, Barcelo M, Represas-Represas C, Comeche L, Catalan P, Fernandez-Villar A, Lopez-Campos JL, Echave-Sustaeta J, Soler-Cataluna JJ
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:1549-1554
Published Date: 3 June 2021
Circ-HACE1 Aggravates Cigarette Smoke Extract-Induced Injury in Human Bronchial Epithelial Cells via Regulating Toll-Like Receptor 4 by Sponging miR-485-3p
Zhou F, Cao C, Chai H, Hong J, Zhu M
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:1535-1547
Published Date: 1 June 2021
Impact of Exercise Capacity Upon Respiratory Functions, Perception of Dyspnea, and Quality of Life in Patients with Chronic Obstructive Pulmonary Disease
Liu W, Liu Y, Li X
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:1529-1534
Published Date: 1 June 2021

Early Detection of COPD: An Opportunistic Case Finding Study in Smokers and Ex-Smokers Visiting a Medical Centre


Rokach A, Bohadana A, Kotek O, Shuali CC, Azulai H, Babai P, Freier-Dror Y, Izbicki G
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:1519-1527
Published Date: 1 June 2021

Clinical Characteristics of COPD Patients According to COPD Assessment Test (CAT) Score Level: Cross-Sectional Study
Gil HI, Zo S, Jones PW, Kim BG, Kang N, Choi Y, Cho HK, Kang D, Cho J, Park HY, Shin SH
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:1509-1517
Published Date: 1 June 2021

A Proteomics-Based Analysis of Blood Biomarkers for the Diagnosis of COPD Acute Exacerbation
Kim SH, Ahn HS, Park JS, Yeom J, Yu J, Kim K, Oh YM
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:1497-1508
Published Date: 1 June 2021

Longitudinal Imaging-Based Clusters in Former Smokers of the COPD Cohort Associate with Clinical Characteristics: The SubPopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS)
Zou C, Li F, Choi J, Haghighi B, Choi S, Rajaraman PK, Comellas AP, Newell Jnr JD, Lee CH, Barr RG, Bleecker E, Cooper CB, Couper D, Han M, Hansel NN, Kanner RE, Kazerooni EA, Kleerup EC, Martinez FJ, O'Neal W, Paine III R, Rennard SI, Smith BM, Woodruff PG, Hoffman EA, Lin CL
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:1477-1496
Published Date: 31 May 2021
A Cohort Study to Evaluate the Risk of Hospitalisation for Congestive Heart Failure Associated with the Use of Aclidinium and Other Chronic Obstructive Pulmonary Disease Medications in the UK Clinical Practice Research Datalink
Rebordosa C, Plana E, Rubino A, Aguado J, Lei A, Daoud S, Saigi-Morgui N, Perez-Gutthann S, Rivero-Ferrer E
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:1461-1475
Published Date: 31 May 2021

Correlation of Luminal Mucus Score in Large Airways with Lung Function and Quality of Life in Severe Acute Exacerbation of COPD: A Cross-Sectional Study
Yang C, Zeng HH, Du YJ, Huang J, Zhang QY, Lin K
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:1449-1459
Published Date: 28 May 2021
Antimicrobial Peptides SLPI and Beta Defensin-1 in Sputum are Negatively Correlated with FEV1
Cane J, Tregidgo L, Thulborn S, Finch D, Bafadhel M
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:1437-1447
Published Date: 28 May 2021
T-Helper 17 Cell/Regulatory T-Cell Imbalance in COPD Combined with T2DM Patients
Wang C, Wang H, Dai L, Zhang J, Fang L, Liu L, Fu W, Tang D
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:1425-1435
Published Date: 27 May 2021
Eicosanoids and Eosinophilic Inflammation of Airways in Stable COPD
Celejewska-Wójcik N, Kania A, Górka K, Nastałek P, Wójcik K, Gielicz A, Mastalerz L, Sanak M, Sładek K
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:1415-1424
Published Date: 25 May 2021
Reduced Variability of Endurance Time in New Protocols for Exercise Tests in COPD [Corrigendum]
Tufvesson E, Radner F, Papapostolou G, Jarenbäck L, Jönsson S, Nihlén U, Ankerst J, Tunsäter A, Peterson S, Bjermer L, Eriksson G
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:1413-1414
Published Date: 20 May 2021
The Characteristics of Airflow Limitation and Future Exacerbations in Different GOLD Groups of COPD Patients
Song Q, Zhao YY, Zeng YQ, Liu C, Cheng W, Deng MH, Li X, Ma LB, Chen Y, Cai S, Chen P
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:1401-1412
Published Date: 20 May 2021
Chest Dynamic-Ventilatory Digital Radiography in Chronic Obstructive or Restrictive Lung Disease
Ohkura N, Tanaka R, Watanabe S, Hara J, Abo M, Nakade Y, Horii J, Matsuura Y, Inoue D, Takata M, Tamura M, Matsumoto I, Sanada S, Kasahara K
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:1393-1399
Published Date: 18 May 2021
Physical Frailty in COPD Patients with Chronic Respiratory Failure
Gephine S, Mucci P, Grosbois JM, Maltais F, Saey D
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:1381-1392
Published Date: 17 May 2021

Aerobic Exercise Alleviates Inflammation, Oxidative Stress, and Apoptosis in Mice with Chronic Obstructive Pulmonary Disease
Wang X, Wang Z, Tang D
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:1369-1379
Published Date: 17 May 2021

Chronic Obstructive Pulmonary Disease (COPD) in Population Studies in Russia and Norway: Comparison of Prevalence, Awareness and Management
Cook S, Eggen AE, Hopstock LA, Malyutina S, Shapkina M, Kudryavtsev AV, Melbye H, Quint JK
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:1353-1368
Published Date: 14 May 2021
Bronchial Diseases are Insufficiently Defined with the Term COPD
von Wichert P
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:1349-1352
Published Date: 14 May 2021
Effect of Gender on Lung Function and Patient-Reported Outcomes in Patients with COPD Receiving Nebulized Glycopyrrolate [Corrigendum]
Ohar JA, Ozol-Godfrey A, Goodin T, Sanjar S
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:1347-1348
Published Date: 14 May 2021
Etanercept Protected Against Cigarette Smoke Extract-Induced Inflammation and Apoptosis of Human Pulmonary Artery Endothelial Cells via Regulating TNFR1
Xue H, Xie B, Xu N, Li H, Chen Q, Xie W, Wang H
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:1329-1345
Published Date: 11 May 2021

Towards Rational Prescription of Common Inhaler Medication in the Multimorbid COPD Patient
Tsiligianni I, Hoeines KJ, Jensen C, Kocks JWH, Ställberg B, Vicente C, Peché R
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:1315-1327
Published Date: 11 May 2021

A Systematic Literature Review of the Humanistic Burden of COPD
Hurst JR, Siddiqui MK, Singh B, Varghese P, Holmgren U, de Nigris E
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:1303-1314
Published Date: 10 May 2021
Reply to: “Intraclass Difference in Pneumonia Risk with Fluticasone and Budesonide in COPD: A Systematic Review of Evidence from Direct-Comparison Studies” [Letter]
Barnes NC, Singh D, Lipson DA
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:1299-1301
Published Date: 10 May 2021
PARC/CCL18 is Associated with Inflammation, Emphysema Severity and Application of Inhaled Corticosteroids in Hospitalized COPD Patients
Duan H, Liang L, Liu X, Xie S, Wang C
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:1287-1297
Published Date: 10 May 2021
Repetitive Saliva Swallowing Test Predicts COPD Exacerbation [Corrigendum]
Yoshimatsu Y, Tobino K, Sueyasu T, Nishizawa S, Ko Y, Yasuda M, Ide H, Tsuruno K, Miyajima H
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:1285-1286
Published Date: 10 May 2021

Burden and Characteristics of Severe Chronic Hypoxemia in a Real-World Cohort of Subjects with COPD
Zysman M, Deslee G, Perez T, Burgel PR, Le Rouzic O, Brinchault-Rabin G, Nesme-Meyer P, Court-Fortune I, Jebrak G, Chanez P, Caillaud D, Paillasseur JL, Roche N
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:1275-1284
Published Date: 10 May 2021

Incidence and Prognostic Factors of Respiratory Viral Infections in Severe Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Jang JG, Ahn JH, Jin HJ
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:1265-1273
Published Date: 7 May 2021

Real-World Treatment Patterns of Multiple-Inhaler Triple Therapy Among Patients with Chronic Obstructive Pulmonary Disease in UK General Practice
Sansbury LB, Bains C, Lipson DA, Ismaila AS, Landis SH
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:1255-1264
Published Date: 6 May 2021

Management of Cough in Patients with Chronic Obstructive Pulmonary Disease: Results of the Multicenter Randomized Placebo-Controlled Clinical Trial
Avdeev SN, Vizel AA, Abrosimov VN, Zaicev AA, Ignatova GL, Khamitov RF, Mikhaylusova MP, Shapovalova JS, Pavlysh EF, Trofimov BI, Emelyanov AV, Martynenko TI, Martynenko VA, Kostina NE, Chizhov DA, Chizhova OY, Kuzubova NA, Makova EV, Makarova EV
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:1243-1253
Published Date: 5 May 2021
Discordant Quantitative and Visual CT Assessments in the Diagnosis of Emphysema
Amaza IP, O'Shea AMJ, Fortis S, Comellas AP
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:1231-1242
Published Date: 3 May 2021
Response to the Letter to the Editor Regarding “Intraclass Difference in Pneumonia Risk with Fluticasone and Budesonide in COPD: A Systematic Review of Evidence from Direct-Comparison Studies” [Response to Letter]
Lodise TP, Sethi S
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:1227-1229
Published Date: 10 May 2021


Treatment of COPD with Long-Acting Bronchodilators: Association Between Early and Longer-Term Clinically Important Improvement
Vogelmeier CF, Naya IP, Maltais F, Bjermer L, Kerwin EM, Tombs L, Jones PW, Compton C, Lipson DA, Boucot IH
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:1215-1226
Published Date: 3 May 2021

Adherence and Efficacy of Smoking Cessation Treatment Among Patients with COPD in China
Qin R, Liu Z, Zhou X, Cheng A, Cui Z, Li J, Wei X, Xiao D, Wang C
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:1203-1214
Published Date: 30 April 2021
Inspiratory Flow Parameters Through Dry Powder Inhalers in Healthy Volunteers and Patients with Chronic Obstructive Pulmonary Disease (COPD): Device Resistance Does Not Limit Use in COPD
Jõgi R, Mattila L, Vahteristo M, Takala A, Lähelmä S, Vartiainen VA, Lindqvist A
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:1193-1201
Published Date: 30 April 2021
Diagnostic Accuracy of a Two-Stage Sequential Screening Strategy Implemented by Community Health Workers (CHWs) to Identify Individuals with COPD in Rural India
Jarhyan P, Hutchinson A, Khatkar R, Kondal D, Botti M, Prabhakaran D, Mohan S
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:1183-1192
Published Date: 29 April 2021

The Relation Between Clinical Phenotypes, GOLD Groups/Stages and Mortality in COPD Patients – A Prospective Multicenter Study
Brat K, Svoboda M, Zatloukal J, Plutinsky M, Volakova E, Popelkova P, Novotna B, Dvorak T, Koblizek V
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:1171-1182
Published Date: 28 April 2021
Native American Patients with Chronic Obstructive Pulmonary Disease Exacerbations in a Tertiary Academic Medical Center – A Pilot Study
Wu H, Rhoades DA, Chen S, Brown B
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:1163-1170
Published Date: 28 April 2021

Umeclidinium/Vilanterol Compared with Fluticasone Propionate/Salmeterol, Budesonide/Formoterol, and Tiotropium as Initial Maintenance Therapy in Patients with COPD Who Have High Costs and Comorbidities
Kalhan R, Slade D, Ray R, Moretz C, Germain G, Laliberté F, Shen Q, Duh MS, MacKnight SD, Hahn B
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:1149-1161
Published Date: 22 April 2021


A Dose-Ranging Study of the Novel Inhaled Dual PDE 3 and 4 Inhibitor Ensifentrine in Patients with COPD Receiving Maintenance Tiotropium Therapy
Ferguson GT, Kerwin EM, Rheault T, Bengtsson T, Rickard K
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:1137-1148
Published Date: 22 April 2021
Revision Bronchoscopy After Endobronchial Valve Treatment for Emphysema: Indications, Findings and Outcomes
Roodenburg SA, Klooster K, Hartman JE, Koster TD, van Dijk M, Slebos DJ
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:1127-1136
Published Date: 21 April 2021
Sociodemographic and Clinical Variables Related to the Overburden of the Informal Caregivers of Patients Hospitalized for Chronic Obstructive Pulmonary Disease Exacerbations
Fernández-García S, Represas-Represas C, Ruano-Raviña A, Fernández-García A, González-Montaos A, Priegue-Carrera A, Pérez-Ríos M, Fernández-Villar A
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:1119-1126
Published Date: 20 April 2021

Factors Associated with Chronic Obstructive Pulmonary Diseases in Nepal: Evidence from a Nationally Representative Population-Based Study
Karki KB, Poudyal A, Shrestha N, Mahato NK, Aryal KK, Sijapati MJ, Bista B, Gautam N, Subedi R, Siddiquee NKA, Gyanwali P, Kuch U, Groneberg DA, Jha AK, Dhimal M
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:1109-1118
Published Date: 20 April 2021
Gender Differences in Chronic Obstructive Pulmonary Disease Symptom Clusters
Zhang H, Wu F, Yi H, Xu D, Jiang N, Li Y, Li M, Wang K
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:1101-1107
Published Date: 20 April 2021
A Frailty Assessment Tool to Predict In-Hospital Mortality in Patients with Acute Exacerbations of Chronic Obstructive Pulmonary Disease
Gu JJ, Liu Q, Zheng LJ
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:1093-1100
Published Date: 20 April 2021


Long-Acting Bronchodilator Use in Chronic Obstructive Pulmonary Disease in Primary Care in New Zealand: A Retrospective Study of Treatment Patterns and Evolution Using the HealthStat Database
Milea D, Yeo SH, Nam Y, Navarro Rojas AA, Shantakumar S, Beale J, Marett B, Young RP, Scott RJ, Gribben B
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:1075-1091
Published Date: 20 April 2021

Impact of Comorbidity Prevalence and Cardiovascular Disease Status on the Efficacy and Safety of Nebulized Glycopyrrolate in Patients with COPD
Putcha N, Ozol-Godfrey A, Sanjar S, Sharma S
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:1061-1073
Published Date: 19 April 2021

Comparative Study of Inhaler Device Handling Technique and Risk Factors for Critical Inhaler Errors in Korean COPD Patients
Jang JG, Chung JH, Shin KC, Jin HJ, Lee KH, Ahn JH
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:1051-1059
Published Date: 19 April 2021

Integrating Home-Based Exercise Training with a Hospital at Home Service for Patients Hospitalised with Acute Exacerbations of COPD: Developing the Model Using Accelerated Experience-Based Co-Design
Barker RE, Brighton LJ, Maddocks M, Nolan CM, Patel S, Walsh JA, Polgar O, Wenneberg J, Kon SSC, Wedzicha JA, Man WDC, Farquhar M
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:1035-1049
Published Date: 19 April 2021

Lung Deposition and Inspiratory Flow Rate in Patients with Chronic Obstructive Pulmonary Disease Using Different Inhalation Devices: A Systematic Literature Review and Expert Opinion
Baloira A, Abad A, Fuster A, García Rivero JL, García-Sidro P, Márquez-Martín E, Palop M, Soler N, Velasco JL, González-Torralba F
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:1021-1033
Published Date: 19 April 2021
One-Year Evolution of Symptoms and Health Status of the COPD Multi-Dimensional Phenotypes: Results from the Follow-Up of the STORICO Observational Study
Incalzi RA, Blasi F, Scichilone N, Zullo A, Simoni L, Canonica GW
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:1007-1020
Published Date: 20 April 2021
Longitudinal Relationship Between Growth Differentiation Factor 11 and Physical Activity in Chronic Obstructive Pulmonary Disease
Tanaka R, Koarai A, Yamada M, Fujino N, Ichikawa T, Numakura T, Onodera K, Kyogoku Y, Tamada T, Miura M, Minakata Y, Ichinose M, Sugiura H
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:999-1006
Published Date: 15 April 2021

Treatment of COPD Groups GOLD A and B with Inhaled Corticosteroids in the COSYCONET Cohort – Determinants and Consequences
Lutter JI, Jörres RA, Trudzinski FC, Alter P, Kellerer C, Watz H, Welte T, Bals R, Kauffmann-Guerrero D, Behr J, Holle R, Vogelmeier CF, Kahnert K
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:987-998
Published Date: 14 April 2021
Peripheral Blood Eosinophils and Nine Years Mortality in COPD Patients
Prudente R, Ferrari R, Mesquita CB, Machado LHS, Franco EAT, Godoy I, Tanni SE
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:979-985
Published Date: 14 April 2021

Effects of Proprioceptive Neuromuscular Facilitation Stretching Combined with Aerobic Training on Pulmonary Function in COPD Patients: A Randomized Controlled Trial
Liu K, Yu X, Cui X, Su Y, Sun L, Yang J, Han W
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:969-977
Published Date: 13 April 2021

Catching “Early” COPD – The Diagnostic Conundrum
Yip KP, Stockley RA, Sapey E
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:957-968
Published Date: 13 April 2021
Effect of SGRQ-Defined Chronic Bronchitis at Baseline on Treatment Outcomes in Patients with COPD Receiving Nebulized Glycopyrrolate
Tashkin DP, Ozol-Godfrey A, Sharma S, Sanjar S
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:945-955
Published Date: 12 April 2021

Peak Inspiratory Flow Rate in COPD: An Analysis of Clinical Trial and Real-World Data
Anderson M, Collison K, Drummond MB, Hamilton M, Jain R, Martin N, Mularski RA, Thomas M, Zhu CQ, Ferguson GT
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:933-943
Published Date: 12 April 2021
Circ-OSBPL2 Contributes to Smoke-Related Chronic Obstructive Pulmonary Disease by Targeting miR-193a-5p/BRD4 Axis
Zheng C, Zhang Y, Zhao Y, Duan Y, Mu Q, Wang X
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:919-931
Published Date: 7 April 2021
Adherence to Treatment Recommendations for Chronic Obstructive Pulmonary Disease - Results from the Swedish National Airway Register
Larsson K, Ekberg-Jansson A, Stridsman C, Hanno M, Vanfleteren LEGW
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:909-918
Published Date: 6 April 2021

The Perception of Physicians on Gender-Specific Differences in the Diagnosis of COPD: Results from a Questionnaire-Based Survey
Raherison-Semjen C, Mezzi K, Kostikas K, Mackay AJ, Singh D
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:901-907
Published Date: 1 April 2021
CircANKRD11 Knockdown Protects HPMECs from Cigarette Smoke Extract-Induced Injury by Regulating miR-145-5p/BRD4 Axis
Wang Z, Zuo Y, Gao Z
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:887-899
Published Date: 1 April 2021
RETRACTED ARTICLE: The Mechanism of Penehyclidine Hydrochloride and Its Effect on the Inflammatory Response of Lung Tissue in Rats with Chronic Obstructive Pulmonary Disease During Mechanical Ventilation
Chen Z, Zhang Y, Wu J, Gao X, Huang C, Lin Y, Xu X, Li Y
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:877-885
Published Date: 31 March 2021
Improvement in Lung Function and Patient-Reported Outcomes in Patients with COPD with Comorbid Anxiety and Depression Receiving Nebulized Glycopyrrolate in the GOLDEN 3 and 4 Studies
Hanania NA, Yohannes AM, Ozol-Godfrey A, Tocco M, Goodin T, Sharma S, Sanjar S
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:865-875
Published Date: 31 March 2021

Favorable Response to Long-Term Azithromycin Therapy in Bronchiectasis Patients with Chronic Airflow Obstruction Compared to Chronic Obstructive Pulmonary Disease Patients without Bronchiectasis
Choi Y, Shin SH, Lee H, Cho HK, Im Y, Kang N, Choi HS, Park HY
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:855-863
Published Date: 30 March 2021
The Relationship Between Morning Symptoms and the Risk of Future Exacerbations in COPD [Corrigendum]
Sun T, Li X, Cheng W, Peng Y, Zhao Y, Liu C, Zeng Y, Chen Y, Cai S, Chen P
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:853-854
Published Date: 29 March 2021

Association of Chronic Obstructive Pulmonary Disease with Morbidity and Mortality in Patients with Peripheral Artery Disease: Insights from the EUCLID Trial
Galani J, Mulder H, Rockhold FW, Weissler EH, Baumgartner I, Berger JS, Blomster JI, Fowkes FGR, Hiatt WR, Katona BG, Norgren L, Mahaffey KW, Quint JK, Patel MR, Jones WS
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:841-851
Published Date: 29 March 2021

There is No Fast Track to Identify Fast Decliners in Alpha-1 Antitrypsin Deficiency by Spirometry: A Longitudinal Study of Repeated Measurements
Stockley JA, Stockley RA, Sapey E
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:835-840
Published Date: 29 March 2021

Relationship of Red Cell Index with the Severity of Chronic Obstructive Pulmonary Disease
Huang Y, Wang J, Shen J, Ma J, Miao X, Ding K, Jiang B, Hu B, Fu F, Huang L, Cao M, Zhang X
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:825-834
Published Date: 26 March 2021
The Effects of Low Pressure Domiciliary Non-Invasive Ventilation on Clinical Outcomes in Patients with Severe COPD Regardless Having Hypercapnia
Theunisse C, Ponssen HH, de Graaf NTC, Scholten-Bakker M, Willemsen SP, Cheung D
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:817-824
Published Date: 26 March 2021

Withdrawal of Inhaled Corticosteroids in Patients with COPD – A Prospective Observational Study
Nielsen AO, Hilberg O, Jensen JUS, Kristensen SH, Frølund JC, Langkilde PK, Løkke A
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:807-815
Published Date: 26 March 2021
High Blood Eosinophil and YKL-40 Levels, as Well as Low CXCL9 Levels, are Associated with Increased Readmission in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Peng J, Yu Q, Fan S, Chen X, Tang R, Wang D, Qi D
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:795-806
Published Date: 26 March 2021
Provision of Palliative Care in Patients with COPD: A Survey Among Pulmonologists and General Practitioners
Broese JMC, van der Kleij RMJJ, Verschuur EML, Kerstjens HAM, Engels Y, Chavannes NH
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:783-794
Published Date: 26 March 2021
Oronasal versus Nasal Masks for Non-Invasive Ventilation in COPD: A Randomized Crossover Trial
Majorski DS, Callegari JC, Schwarz SB, Magnet FS, Majorski R, Storre JH, Schmoor C, Windisch W
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:771-781
Published Date: 26 March 2021
Prescription Patterns in Patients with Chronic Obstructive Pulmonary Disease and Osteoporosis
Liao KM, Chiu KL, Chen CY
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:761-769
Published Date: 25 March 2021
Are COPD Prescription Patterns Aligned with Guidelines? Evidence from a Canadian Population-Based Study
Bahremand T, Etminan M, Roshan-Moniri N, De Vera MA, Tavakoli H, Sadatsafavi M
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:751-759
Published Date: 25 March 2021


The Incidence and Risk Analysis of Lung Cancer Development in Patients with Chronic Obstructive Pulmonary Disease: Possible Effectiveness of Annual CT-Screening
Machida H, Inoue S, Shibata Y, Kimura T, Ota T, Ishibashi Y, Murano H, Furuyama K, Yang S, Nakano H, Sato K, Sato M, Nemoto T, Nishiwaki M, Yamauchi K, Igarashi A, Watanabe M
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:739-749
Published Date: 25 March 2021
Day-to-Day Variability of Parameters Recorded by Home Noninvasive Positive Pressure Ventilation for Detection of Severe Acute Exacerbations in COPD
Jiang W, Chao Y, Wang X, Chen C, Zhou J, Song Y
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:727-737
Published Date: 22 March 2021
Association Between Airflow Limitation and Carotid Intima-Media Thickness in the Japanese Population
Watanabe K, Onoue A, Omori H, Kubota K, Yoshida M, Katoh T
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:715-726
Published Date: 19 March 2021
The Impact of Exacerbation Frequency on Clinical and Economic Outcomes in Swedish COPD Patients: The ARCTIC Study
Larsson K, Janson C, Lisspers K, Ställberg B, Johansson G, Gutzwiller FS, Mezzi K, Bjerregaard BK, Jorgensen L
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:701-713
Published Date: 18 March 2021
The Impact of Exacerbation History on the Safety and Efficacy of Aclidinium in Patients with Chronic Obstructive Pulmonary Disease and Increased Cardiovascular Risk: ASCENT-COPD Trial
Wise RA, Chapman KR, Scirica BM, Daoud SZ, Lythgoe D, Garcia-Gil E
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:689-699
Published Date: 18 March 2021

Predicting Hospitalization Due to COPD Exacerbations in Swedish Primary Care Patients Using Machine Learning – Based on the ARCTIC Study
Ställberg B, Lisspers K, Larsson K, Janson C, Müller M, Łuczko M, Kjøller Bjerregaard B, Bacher G, Holzhauer B, Goyal P, Johansson G
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:677-688
Published Date: 16 March 2021

Prediction of Mortality Using Different COPD Risk Assessments – A 12-Year Follow-Up
Athlin Å, Giezeman M, Hasselgren M, Montgomery S, Lisspers K, Ställberg B, Janson C, Sundh J
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:665-675
Published Date: 16 March 2021
Prevalence and Risk Factors of Chronic Obstructive Pulmonary Disease in Kashi Region, Northwestern China
Li L, Zhong X, Zheng A, JianKun C, Budukadeer AA, Aini P, Tuerxun M, Yasen M, Ma T, Ren J, Semaiti R, Xie C, Li F, Rexiati M, Tang L, Abudurexiti G, Zheng D, Li JQ
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:655-663
Published Date: 16 March 2021
Characteristics of COPD Phenotypes in Serbia
Lazic Z, Stankovic I, Milenkovic B, Zvezdin B, Hromis S, Jankovic S, Cupurdija V
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:643-654
Published Date: 16 March 2021

The Utilization and Safety of Umeclidinium and Umeclidinium/Vilanterol in UK Primary Care: A Retrospective Cohort Study
Requena G, Dedman D, Quint JK, Ghosh RE, Williams R, Pimenta JM
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:629-642
Published Date: 10 March 2021

Therapeutic Success of Tiotropium/Olodaterol, Measured Using the Clinical COPD Questionnaire (CCQ), in Routine Clinical Practice: A Multinational Non-Interventional Study
Valipour A, Avdeev S, Barczyk A, Bayer V, Fridlender Z, Georgieva M, Kudela O, Medvedchikov A, Miron R, Sanzharovskaya M, Šileikienė V, Šorli J, Spielmanns M, Szalai Z
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:615-628
Published Date: 10 March 2021

Economic Burden of COPD by Disease Severity – A Nationwide Cohort Study in Denmark
Løkke A, Lange P, Lykkegaard J, Ibsen R, Andersson M, de Fine Licht S, Hilberg O
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:603-613
Published Date: 10 March 2021
Association Between Statin Use and Exacerbation of Chronic Obstructive Pulmonary Disease Among Patients Receiving Corticosteroids
Huang YJ, Kao S, Kao LT, Chian CF, Chung CH, Chien WC, Wang KY
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:591-602
Published Date: 5 March 2021


Statins in High-Risk Chronic Obstructive Pulmonary Disease Outpatients: No Impact on Time to First Exacerbation and All-Cause Mortality – The STATUETTE Cohort Study
Damkjær M, Håkansson K, Kallemose T, Ulrik CS, Godtfredsen N
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:579-589
Published Date: 5 March 2021


The Impact of Budesonide/Formoterol pMDI Medication Reminders on Adherence in Chronic Obstructive Pulmonary Disease (COPD) Patients: Results of a Randomized, Phase 4, Clinical Study
Criner GJ, Cole T, Hahn KA, Kastango K, Eudicone J, Gilbert I
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:563-577
Published Date: 4 March 2021

Neurological and Psychiatric Comorbidities in Chronic Obstructive Pulmonary Disease
Puteikis K, Mameniškienė R, Jurevičienė E
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:553-562
Published Date: 3 March 2021
Polyvalent Immunoglobulin as a Potential Treatment Option for Patients with Recurrent COPD Exacerbations
Unninayar D, Abdallah SJ, Cameron DW, Cowan J
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:545-552
Published Date: 2 March 2021
Quantitative CT Analysis of Small Airway Remodeling in Patients with Chronic Obstructive Pulmonary Disease by a New Image Post-Processing System
Qin S, Yu X, Ma Q, Lin L, Li Q, Liu H, Zhang L, Leng S, Han W
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:535-544
Published Date: 2 March 2021


COPD Management in Community Pharmacy Results in Improved Inhaler Use, Immunization Rate, COPD Action Plan Ownership, COPD Knowledge, and Reductions in Exacerbation Rates
Fathima M, Bawa Z, Mitchell B, Foster J, Armour C, Saini B
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:519-533
Published Date: 2 March 2021

Benefit/Risk Profile of Single-Inhaler Triple Therapy in COPD
Bourbeau J, Bafadhel M, Barnes NC, Compton C, Di Boscio V, Lipson DA, Jones PW, Martin N, Weiss G, Halpin DMG
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:499-517
Published Date: 1 March 2021

Long-Term Azithromycin Maintenance Treatment in Patients with Frequent Exacerbations of Chronic Obstructive Pulmonary Disease
Talman S, Uzun S, Djamin RS, Baart SJ, Grootenboers MJJH, Aerts J, van der Eerden M
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:495-498
Published Date: 1 March 2021
Influence of Cell Quality on Inflammatory Biomarkers in COPD Sputum Supernatant
Pedersen F, Trinkmann F, Abdo M, Kirsten AM, Rabe KF, Watz H, Baraldo S, Saetta M, Hohlfeld JM, Holz O
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:487-493
Published Date: 1 March 2021
Development and Assessment of Prediction Models for the Development of COPD in a Typical Rural Area in Northwest China
Wang Y, Li Z, Li FS
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:477-486
Published Date: 26 February 2021

Undiagnosed and Misdiagnosed Chronic Obstructive Pulmonary Disease: Data from the BOLD Australia Study
Petrie K, Toelle BG, Wood-Baker R, Maguire GP, James AL, Hunter M, Johns DP, Marks GB, George J, Abramson MJ
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:467-475
Published Date: 25 February 2021

Characteristics, Management and In-Hospital Clinical Outcomes Among Inpatients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease in China: Results from the Phase I Data of ACURE Study
Liang C, Mao X, Niu H, Huang K, Dong F, Chen Y, Huang K, Zhan Q, Huang Y, Zhang Y, Yang T, Wang C
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:451-465
Published Date: 25 February 2021
Certified Smoking Cessation Units in Spain: High Potential for Detection of Undiagnosed Chronic Obstructive Pulmonary Disease and Profile of Newly Diagnosed Cases
Riesco-Miranda JA, Solano-Reina S, Rábade-Castedo C, de Granda-Orive JI, Pastor-Esplá E, García-Rueda M, Callejas-Gonzalez FJ, Azpeitia-Anadón Á, Mas S, Jiménez-Ruiz CA
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:443-450
Published Date: 25 February 2021
Cost-Effectiveness of Dual Bronchodilator Indacaterol/Glycopyrronium for COPD Treatment in China
Gong S, Hu H, Zhao K, Yang T
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:433-441
Published Date: 23 February 2021
Bronchial Variation: Anatomical Abnormality May Predispose Chronic Obstructive Pulmonary Disease
Sun XW, Lin YN, Ding YJ, Li SQ, Li HP, Li QY
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:423-431
Published Date: 23 February 2021
Factors for the Variability of Three Acceptable Maximal Expiratory Flow–Volume Curves in Chronic Obstructive Pulmonary Disease
Yamamoto M, Konno S, Makita H, Nitta K, Shimizu K, Suzuki M, Nishida M, Sugita J, Teshima T, Nishimura M
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:415-422
Published Date: 24 February 2021

Assessment of Ventilatory Heterogeneity in Chronic Obstructive Pulmonary Disease Using the Inspired Sinewave Test
Bruce RM, Phan PA, Rigolli M, Tran MC, Pacpaco E, Rahman NM, Farmery AD
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:401-413
Published Date: 23 February 2021
Dynamic Increase of Red Cell Distribution Width Predicts Increased Risk of 30-Day Readmission in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Zhu M, Dai L, Wan L, Zhang S, Peng H
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:393-400
Published Date: 24 February 2021

Pulmonary Rehabilitation in a Post-COVID-19 World: Telerehabilitation as a New Standard in Patients with COPD
Tsutsui M, Gerayeli F, Sin DD
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:379-391
Published Date: 19 February 2021
Systemic Galectin-3 in Smokers with Chronic Obstructive Pulmonary Disease and Chronic Bronchitis: The Impact of Exacerbations
Sundqvist M, Andelid K, Ekberg-Jansson A, Bylund J, Karlsson-Bengtsson A, Lindén A
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:367-377
Published Date: 19 February 2021

Small Airways Disease, Biomarkers and COPD: Where are We?
Chukowry PS, Spittle DA, Turner AM
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:351-365
Published Date: 18 February 2021
Neutrophil-to-Lymphocyte Ratio Predicts Clinical Outcome of Severe Acute Exacerbation of COPD in Frequent Exacerbators
Lu FY, Chen R, Li N, Sun XW, Zhou M, Li QY, Guo Y
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:341-349
Published Date: 17 February 2021

Association Between Thyroid Function and Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Huang D, Wu D, He J, Chen M, Zhao X, Li D, Wu B
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:333-339
Published Date: 17 February 2021

Standardisation of Clinical Assessment, Management and Follow-Up of Acute Hospitalised Exacerbation of COPD: A Europe-Wide Consensus
Ramakrishnan S, Janssens W, Burgel PR, Contoli M, Franssen FME, Greening NJ, Greulich T, Gyselinck I, Halner A, Huerta A, Morgan RL, Quint JK, Vanfleteren LEGW, Vermeersch K, Watz H, Bafadhel M
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:321-332
Published Date: 16 February 2021

The Prevalence of Chronic Obstructive Pulmonary Disease (COPD) and the Heterogeneity of Risk Factors in the Canadian Population: Results from the Canadian Obstructive Lung Disease (COLD) Study
Leung C, Bourbeau J, Sin DD, Aaron SD, FitzGerald JM, Maltais F, Marciniuk DD, O'Donnell D, Hernandez P, Chapman KR, Walker B, Road JD, Zheng L, Zou C, Hogg JC, Tan WC
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:305-320
Published Date: 12 February 2021
The Ventilatory Strategy to Minimize Expiratory Flow Rate in Ventilated Patients with Chronic Obstructive Pulmonary Disease
Tsuboi N, Tsuboi K, Nosaka N, Nishimura N, Nakagawa S
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:301-304
Published Date: 12 February 2021


GOLD in Practice: Chronic Obstructive Pulmonary Disease Treatment and Management in the Primary Care Setting


Yawn BP, Mintz ML, Doherty DE
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:289-299
Published Date: 12 February 2021
Association Between Blood Eosinophils and Mortality in Critically Ill Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Retrospective Cohort Study
Yang J, Yang J
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:281-288
Published Date: 11 February 2021

The Impact of Muscarinic Receptor Antagonists on Airway Inflammation: A Systematic Review
Calzetta L, Coppola A, Ritondo BL, Matino M, Chetta A, Rogliani P
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:257-279
Published Date: 12 February 2021
Poor Work Efficiency is Associated with Poor Exercise Capacity and Health-Related Quality of Life in Patients with Chronic Obstructive Pulmonary Disease
Yang SH, Yang MC, Wu YK, Wu CW, Hsieh PC, Kuo CY, Tzeng IS, Lan CC
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:245-256
Published Date: 10 February 2021


Predicting Re-Exacerbation Timing and Understanding Prolonged Exacerbations: An Analysis of Patients with COPD in the ECLIPSE Cohort
Meeraus WH, Mullerova H, El Baou C, Fahey M, Hessel EM, Fahy WA
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:225-244
Published Date: 5 February 2021
Application Value of Broadband 3-Dimensional Impulse Oscillometry in COPD
Tang Z, Li M, Chu G, Mou Y, Chen Q, Zhu H
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:215-223
Published Date: 4 February 2021

Eccentric Left Ventricular Hypertrophy and Left and Right Cardiac Function in Chronic Heart Failure with or without Coexisting COPD: Impact on Exercise Performance
Dos Santos PB, Simões RP, Goulart CL, Roscani MG, Marinho RS, Camargo PF, Arbex RF, Casale G, Oliveira CR, Mendes RG, Arena R, Borghi-Silva A
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:203-214
Published Date: 3 February 2021
Association Between Rural Residence and In-Hospital and 30-Day Mortality Among Veterans Hospitalized with COPD Exacerbations
Fortis S, O'Shea AMJ, Beck BF, Comellas A, Vaughan Sarrazin M, Kaboli PJ
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:191-202
Published Date: 2 February 2021

Budesonide/Glycopyrrolate/Formoterol Fumarate Metered Dose Inhaler Improves Exacerbation Outcomes in Patients with COPD without a Recent Exacerbation History: A Subgroup Analysis of KRONOS
Martinez FJ, Ferguson GT, Bourne E, Ballal S, Darken P, Aurivillius M, Dorinsky P, Reisner C
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:179-189
Published Date: 28 January 2021

Combined Pulmonary Fibrosis and Emphysema (CPFE) Clinical Features and Management
Hage R, Gautschi F, Steinack C, Schuurmans MM
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:167-177
Published Date: 28 January 2021

The Impact of Fixed Triple Therapy with Beclometasone/Formoterol/Glycopyrronium on Health Status and Adherence in Chronic Obstructive Pulmonary Disease (COPD) in an Italian Context of Real Life: The TRITRIAL Study Protocol
Richeldi L, Piraino A, Macagno F, Micarelli G, Ingrassia E
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:159-166
Published Date: 27 January 2021
Rcn3 Suppression Was Responsible for Partial Relief of Emphysema as Shown by Specific Type II Alveolar Epithelial Cell Rcn3 CKO Mouse Model
Zhang Q, Wang T, Jin J, Shi X, Huang A, Ma Z, Li J, Wang S, Ma RZ, Fang Q
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:147-158
Published Date: 26 January 2021

Clinical Control Criteria to Determine Disease Control in Patients with Severe COPD: The CLAVE Study
Soler-Cataluña JJ, Almagro P, Huerta A, González-Segura D, Cosío BG
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:137-146
Published Date: 25 January 2021
Needs Assessment and Identification of the Multifaceted COPD Care Bundle in the Emergency Department of a Tertiary Hospital in Nepal
Shrestha R, Shrestha AP, Sonnenberg T, Mistry J, Shrestha R, MacKinney T
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:125-136
Published Date: 22 January 2021

Consistent Pulmonary Drug Delivery with Whole Lung Deposition Using the Aerosphere Inhaler: A Review of the Evidence
Usmani OS, Roche N, Jenkins M, Stjepanovic N, Mack P, De Backer W
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:113-124
Published Date: 18 January 2021
Longitudinal FEV1 and Exacerbation Risk in COPD: Quantifying the Association Using Joint Modelling
Zhudenkov K, Palmér R, Jauhiainen A, Helmlinger G, Stepanov O, Peskov K, Eriksson UG, Wählby Hamrén U
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:101-111
Published Date: 15 January 2021
The Manchester Respiratory Activities of Daily Living Questionnaire: Reliability and Validity of the Chinese Version with Pictorial Enhancement
Siu DCH, So CT, Lau CWL, Hui EHM, Fung A, Chan TM, Chan FSF, Chan CKF, Chen WPW, Cheung SHM, Chan KPY, Poon P, Cheung M, Chan C, Tse J, Fung V, Fong KNK
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:91-100
Published Date: 15 January 2021

Comparison of Dry-Powder Inhaler and Pressurized Metered-Dose Inhaler Formulations of Extrafine Beclomethasone Dipropionate/Formoterol Fumarate/Glycopyrronium in Patients with COPD: The TRI-D Randomized Controlled Trial
Beeh KM, Kuna P, Corradi M, Viaud I, Guasconi A, Georges G
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:79-89
Published Date: 14 January 2021

Identification and Validation of Autophagy-Related Genes in Chronic Obstructive Pulmonary Disease
Sun S, Shen Y, Wang J, Li J, Cao J, Zhang J
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:67-78
Published Date: 12 January 2021

Assessing the Usefulness of the Prevexair Smartphone Application in the Follow-Up High-Risk Patients with COPD
Rodríguez Hermosa JL, Fuster Gomila A, Puente Maestu L, Amado Diago CA, Callejas González FJ, Malo De Molina Ruiz R, Fuentes Ferrer ME, Alvarez-Sala JL, Calle Rubio M
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:53-65
Published Date: 8 January 2021


Validation of the Summit Lab Score in Predicting Exacerbations of Chronic Obstructive Pulmonary Disease Among Individuals with High Arterial Stiffness
Horne BD, Ali R, Midwinter D, Scott-Wilson C, Crim C, Miller BE, Rubin DB
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:41-51
Published Date: 7 January 2021

Towards Personalized Management of Sarcopenia in COPD
van Bakel SIJ, Gosker HR, Langen RC, Schols AMWJ
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:25-40
Published Date: 7 January 2021

Tea Consumption and Risk of Chronic Obstructive Pulmonary Disease in Middle-Aged and Older Singaporean Adults
Ng TP, Gao Q, Gwee X, Chua DQL, Tan WC
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:13-23
Published Date: 7 January 2021

New Insights into Activities of Daily Living Performance in Chronic Obstructive Pulmonary Disease
Kaptain RJ, Helle T, Patomella AH, Weinreich UM, Kottorp A
International Journal of Chronic Obstructive Pulmonary Disease 2021, 16:1-12
Published Date: 7 January 2021