Back to Journals » Drug Design, Development and Therapy » Volume 12

Drug Design, Development and Therapy

ISSN: 1177-8881


Archive: Volume 12, 2018

3-n-butylphthalide exerts neuroprotective effects by enhancing anti-oxidation and attenuating mitochondrial dysfunction in an in vitro model of ischemic stroke

Chen N, Zhou Z, Li J, Li B, Feng J, He D, Luo Y, Zheng X, Luo J, Zhang J

Drug Design, Development and Therapy 2018, 12:4261-4271

Published Date: 14 December 2018

MMI-0100 ameliorates lung inflammation in a mouse model of acute respiratory distress syndrome by reducing endothelial expression of ICAM-1

He B, Geng S, Zhou W, Rui Y, Mu X, Zhang C, You Q, Su X

Drug Design, Development and Therapy 2018, 12:4253-4260

Published Date: 13 December 2018

Gamma linolic acid regulates PHD2 mediated hypoxia and mitochondrial apoptosis in DEN induced Hepatocellular carcinoma

Cui H, Han F, Zhang L, Wang L, Kumar M

Drug Design, Development and Therapy 2018, 12:4241-4252

Published Date: 13 December 2018

Iron oxide nanoparticles as nanocarriers to improve chlorin e6-based sonosensitivity in sonodynamic therapy

Zhang P, Ren Z, Chen Z, Zhu J, Liang J, Liao R, Wen J

Drug Design, Development and Therapy 2018, 12:4207-4216

Published Date: 10 December 2018

Recent development in the strategies projected for chikungunya vaccine in humans

Goyal M, Chauhan A, Goyal V, Jaiswal N, Singh S, Singh M

Drug Design, Development and Therapy 2018, 12:4195-4206

Published Date: 10 December 2018

ADAR1 silencing-induced HUVEC apoptosis is mediated by FGFR2 under hypoxia stress

Jiang Y, Wang Z, Chen X, Wang W, Wang X

Drug Design, Development and Therapy 2018, 12:4181-4189

Published Date: 10 December 2018

Best tigecycline dosing for treatment of infections caused by multidrug-resistant pathogens in critically ill patients with different body weights

Ibrahim MM, Abuelmatty AM, Mohamed GH, Nasr MA, Hussein AK, Ebaed MED, Sarhan HA

Drug Design, Development and Therapy 2018, 12:4171-4179

Published Date: 7 December 2018

SREBP-2, a new target of metformin?

Zhang F, Sun W, Chen J, Jiang L, Yang P, Huang Y, Gong A, Liu S, Ma S

Drug Design, Development and Therapy 2018, 12:4163-4170

Published Date: 6 December 2018

Quercetin inhibits transforming growth factor β1-induced epithelial–mesenchymal transition in human retinal pigment epithelial cells via the Smad pathway

Cai W, Yu D, Fan J, Liang X, Jin H, Liu C, Zhu M, Shen T, Zhang R, Hu W, Wei Q, Yu J

Drug Design, Development and Therapy 2018, 12:4149-4161

Published Date: 6 December 2018

Synthesis of small peptide compounds, molecular docking, and inhibitory activity evaluation against phosphatases PTP1B and SHP2

Kostrzewa T, Sahu KK, Gorska-Ponikowska M, Tuszynski JA, Kuban-Jankowska A

Drug Design, Development and Therapy 2018, 12:4139-4147

Published Date: 5 December 2018

The role of various transporters in the placental uptake of ofloxacin in an in vitro model of human villous trophoblasts

Polachek H, Debotton N, Feinshtein V, Rubin M, Ben-Zvi Z, Holcberg G, Agbaria R, Dahan A

Drug Design, Development and Therapy 2018, 12:4129-4138

Published Date: 4 December 2018

N-acetylcysteine amide provides neuroprotection via Nrf2-ARE pathway in a mouse model of traumatic brain injury

Zhou Y, Wang HD, Zhou XM, Fang J, Zhu L, Ding K

Drug Design, Development and Therapy 2018, 12:4117-4127

Published Date: 4 December 2018

Ferulic acid attenuates liver fibrosis and hepatic stellate cell activation via inhibition of TGF-β/Smad signaling pathway

Mu M, Zuo S, Wu RM, Deng KS, Lu S, Zhu JJ, Zou GL, Yang J, Cheng ML, Zhao XK

Drug Design, Development and Therapy 2018, 12:4107-4115

Published Date: 3 December 2018

The synergistic effect of 2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-glucoside combined with Adriamycin on MCF-7 breast cancer cells

Shen JF, Zhang YZ, Shen H, Pan H, Xu LS, Yuan LN, Ding ZY

Drug Design, Development and Therapy 2018, 12:4083-4094

Published Date: 30 November 2018

Beraprost sodium preconditioning prevents inflammation, apoptosis, and autophagy during hepatic ischemia-reperfusion injury in mice via the P38 and JNK pathways

Deng J, Feng J, Liu T, Lu X, Wang W, Liu N, Lv Y, Liu Q, Guo C, Zhou Y

Drug Design, Development and Therapy 2018, 12:4067-4082

Published Date: 29 November 2018

Spotlight on inhaled ciprofloxacin and its potential in the treatment of non-cystic fibrosis bronchiectasis

Chorepsima S, Kechagias KS, Kalimeris G, Triarides NA, Falagas ME

Drug Design, Development and Therapy 2018, 12:4059-4066

Published Date: 27 November 2018

Pharmacokinetics of single- and multiple-dose roflumilast: an open-label, three-way crossover study in healthy Chinese volunteers

Huang J, Fu CX, Yang XY, Cui C, Yang S, Kuang Y, Guo CX, Hu P, Pei Q, Yang GP

Drug Design, Development and Therapy 2018, 12:4047-4057

Published Date: 26 November 2018

Schisandrin B elicits the Keap1-Nrf2 defense system via carbene reactive metabolite which is less harmful to mice liver

Feng S, Qiu B, Zou L, Liu K, Xu X, Zhu H

Drug Design, Development and Therapy 2018, 12:4033-4046

Published Date: 23 November 2018

Icariin promotes the migration of bone marrow stromal cells via the SDF-1α/HI F-1α/CXCR 4 pathway

Zhu H, Wang X, Han Y, Zhang W, Xin W, Zheng X, Zhang J

Drug Design, Development and Therapy 2018, 12:4023-4031

Published Date: 22 November 2018

Schisandrin B protects against angiotensin II-induced endotheliocyte deficits by targeting Keap1 and activating Nrf2 pathway

Han J, Shi X, Zheng Z, Zhang B, Shi F, Jiang L, Xu J

Drug Design, Development and Therapy 2018, 12:3985-3997

Published Date: 22 November 2018

Valproic acid enhances the viability of random pattern skin flaps: involvement of enhancing angiogenesis and inhibiting oxidative stress and apoptosis

Wu H, Ding J, Wang L, Lin J, Li S, Xiang G, Jiang L, Xu H, Gao W, Zhou K

Drug Design, Development and Therapy 2018, 12:3951-3960

Published Date: 16 November 2018

Gene transfer to rat cerebral cortex mediated by polysorbate 80 and poloxamer 188 nonionic surfactant vesicles

Attia N, Mashal M, Soto-Sánchez C, Martinez-Navarrete G., Fernández E, Grijalvo S, Eritja R, Puras G, Pedraz JL

Drug Design, Development and Therapy 2018, 12:3937-3949

Published Date: 16 November 2018

Arsenic sulfide amplifies JQ1 toxicity via mitochondrial pathway in gastric and colon cancer cells

Tan Z, Zhang X, Kang T, Zhang L, Chen S

Drug Design, Development and Therapy 2018, 12:3913-3927

Published Date: 14 November 2018

A study on screening and antitumor effect of CD55-specific ligand peptide in cervical cancer cells

Liu G, Yin Q, Ji H, Wang Y, Liu H, Jiang L, Zhu F, Li B

Drug Design, Development and Therapy 2018, 12:3899-3912

Published Date: 13 November 2018

CTL019 (tisagenlecleucel): CAR-T therapy for relapsed and refractory B-cell acute lymphoblastic leukemia

Vairy S, Lopes Garcia J, Teira P, Bittencourt H

Drug Design, Development and Therapy 2018, 12:3885-3898

Published Date: 12 November 2018

Risankizumab: an anti-IL-23 antibody for the treatment of psoriasis

Haugh IM, Preston AK, Kivelevitch DN, Menter AM

Drug Design, Development and Therapy 2018, 12:3879-3883

Published Date: 12 November 2018

The therapeutic effects of traditional Chinese medicine Fusu agent in LPS-induced acute lung injury model rats

Gao P, Zhao Z, Zhang C, Wang C, Long K, Guo L, Li B

Drug Design, Development and Therapy 2018, 12:3867-3878

Published Date: 13 November 2018

The effects of macrolides in children with reactive airway disease: a systematic review and meta-analysis of randomized controlled trials

Lei WT, Lin HH, Tsai MC, Hung HH, Cheng YJ, Liu SJ, Lin CY, Yeh TL

Drug Design, Development and Therapy 2018, 12:3825-3845

Published Date: 8 November 2018

An insight into new strategies to combat antifungal drug resistance

Zheng YH, Ma YY, Ding Y, Chen XQ, Gao GX

Drug Design, Development and Therapy 2018, 12:3807-3816

Published Date: 5 November 2018

The effect of food and liquid pH on the integrity of enteric-coated beads from cysteamine bitartrate delayed-release capsules [Corrigendum]

Pavloff N, Hauser TA, Williams C, Isbell SL, Cadieux B, Johnson M

Drug Design, Development and Therapy 2018, 12:3797-3798

Published Date: 5 November 2018

Histopathological study of liver tissue due to methadone consumption and its effect on liver enzymes and inflammatory indices in rat

Amraei M, Mohamadpour M, Hafezi Ahmadi MR, Azizi M, Daemi A, Omidi M, Shirzadpour E

Drug Design, Development and Therapy 2018, 12:3785-3795

Published Date: 5 November 2018

Concomitant food intake does not affect the efficacy of entecavir in chronic hepatitis B patients with virological response: a randomized, multicenter, noninferiority trial

Cho EJ, Yu SJ, Kwon SY, Kim JH, Kim DY, Kim W, Lee JS, Lee JW, Lee YJ, Chae HB, Yoon JH

Drug Design, Development and Therapy 2018, 12:3767-3774

Published Date: 2 November 2018

Identification of new inhibitors of Mdm2–p53 interaction via pharmacophore and structure-based virtual screening

Atatreh N, Ghattas MA, Bardaweel SK, Al Rawashdeh S, Al Sorkhy M

Drug Design, Development and Therapy 2018, 12:3741-3752

Published Date: 2 November 2018

Two-drug regimens for treatment of naïve HIV-1 infection and as maintenance therapy

Corado KC, Caplan MR, Daar ES

Drug Design, Development and Therapy 2018, 12:3731-3740

Published Date: 1 November 2018

Efficacy evaluation of reteplase in a novel canine acute pulmonary thromboembolism model developed by minimally invasive surgery and digital subtraction angiography

Zhang Y, Liu H, Zhang Y, Wu Q, Zhang Y, Zhang J, Zhou X, Jiao H, Fan F, Xue Q, Wang X, Zhong Z

Drug Design, Development and Therapy 2018, 12:3717-3730

Published Date: 1 November 2018

Saponins enhance exon skipping of 2′-O-methyl phosphorothioate oligonucleotide in vitro and in vivo

Wang M, Wu B, Shah SN, Lu P, Lu Q

Drug Design, Development and Therapy 2018, 12:3705-3715

Published Date: 31 October 2018

Meta-analysis of rosuvastatin efficacy in prevention of contrast-induced acute kidney injury

Zhang J, Guo Y, Jin Q, Bian L, Lin P

Drug Design, Development and Therapy 2018, 12:3685-3690

Published Date: 31 October 2018

Formononetin induces vasorelaxation in rat thoracic aorta via regulation of the PI3K/PTEN/Akt signaling pathway

Li T, Zhong Y, Tang T, Luo J, Cui H, Fan R, Wang Y, Wang D

Drug Design, Development and Therapy 2018, 12:3675-3684

Published Date: 1 November 2018

Efficacy and safety of Tongfu powder in acute pancreatitis patients with gastrointestinal dysfunction: a clinical trial

Miao B, Li FW, Zhang SW, Wang H, Qi WJ, Wang C

Drug Design, Development and Therapy 2018, 12:3665-3673

Published Date: 31 October 2018

Pharmacokinetic evaluation of a transdermal anastrozole-in-adhesive formulation

Regenthal R, Voskanian M, Baumann F, Teichert J, Brätter C, Aigner A, Abraham G

Drug Design, Development and Therapy 2018, 12:3653-3664

Published Date: 1 November 2018

Transfer of rosuvastatin into breast milk: liquid chromatography–mass spectrometry methodology and clinical recommendations

Lwin EMP, Leggett C, Ritchie U, Gerber C, Song Y, Hague W, Turner S, Upton R, Garg S

Drug Design, Development and Therapy 2018, 12:3645-3651

Published Date: 29 October 2018

Pharmacokinetic and bioequivalence study comparing a fimasartan/rosuvastatin fixed-dose combination with the concomitant administration of fimasartan and rosuvastatin in healthy subjects

Kang WY, Seong SJ, Ohk B, Gwon MR, Kim BK, Cho S, Shim WS, Lee KT, Kim EH, Yang DH, Lee HW, Yoon YR

Drug Design, Development and Therapy 2018, 12:3607-3615

Published Date: 26 October 2018

Asiatic acid protests against myocardial ischemia/reperfusion injury via modulation of glycometabolism in rat cardiomyocyte

Dai Y, Wang Z, Quan M, Lv Y, Li Y, Xin HB, Qian Y

Drug Design, Development and Therapy 2018, 12:3573-3582

Published Date: 25 October 2018

Lobaplatin inhibits breast cancer progression, cell proliferation while it induces cell apoptosis by downregulating MTDH expression

Tian W, Hao S, Gao B, Jiang Y, Zhang X, Zhang S, Guo L, Zhao J, Zhang G, Chen Y, Li Z, Luo D

Drug Design, Development and Therapy 2018, 12:3563-3571

Published Date: 29 October 2018

Entrectinib and other ALK/TRK inhibitors for the treatment of neuroblastoma

Pacenta HL, Macy ME

Drug Design, Development and Therapy 2018, 12:3549-3561

Published Date: 23 October 2018

Glutathione S-transferase π: a potential role in antitumor therapy

Dong S, Sha H, Xu X, Hu T, Lou R, Li H, Wu J, Dan C, Feng J

Drug Design, Development and Therapy 2018, 12:3535-3547

Published Date: 23 October 2018

Antioxidative stress effects of vitamins C, E, and B12, and their combination can protect the liver against acetaminophen-induced hepatotoxicity in rats

Abdulkhaleq FM, Alhussainy TM, Badr MM, Abu Khalil AA, Gammoh O, Ghanim BY, Qinna NA

Drug Design, Development and Therapy 2018, 12:3525-3533

Published Date: 18 October 2018

Intranasal niosomes of nefopam with improved bioavailability: preparation, optimization, and in-vivo evaluation

Abou-Taleb HA, Khallaf RA, Abdel-Aleem JA

Drug Design, Development and Therapy 2018, 12:3501-3516

Published Date: 17 October 2018

The retinoprotective role of phenytoin

Bartollino S, Chiosi F, di Staso S, Uva M, Pascotto A, Rinaldi M, Keppel Hesselink JM, Costagliola C

Drug Design, Development and Therapy 2018, 12:3485-3489

Published Date: 16 October 2018

The efficacy and safety of aflibercept and conbercept in diabetic macular edema

Cai S, Yang Q, Li X, Zhang Y

Drug Design, Development and Therapy 2018, 12:3471-3483

Published Date: 15 October 2018

Inhibition of sialidase activity as a therapeutic approach

Glanz VY, Myasoedova VA, Grechko AV, Orekhov AN

Drug Design, Development and Therapy 2018, 12:3431-3437

Published Date: 10 October 2018

All-trans retinoic acid can antagonize osteoblastogenesis induced by different BMPs irrespective of their dimerization types and dose-efficiencies

Liu Y, Ma X, Guo J, Lin Z, Zhou M, Bi W, Liu J, Wang J, Lu H, Wu G

Drug Design, Development and Therapy 2018, 12:3419-3430

Published Date: 10 October 2018

Synthesis and anticancer activity of dimeric podophyllotoxin derivatives

Zi C, Yang L, Xu F, Dong F, Yang D, Li Y, Ding Z, Zhou J, Jiang Z, Hu J

Drug Design, Development and Therapy 2018, 12:3393-3406

Published Date: 9 October 2018

Immediate release tablet formulation of varenicline salicylate and comparative pharmacokinetic study in human volunteers

Kwak SS, Lee ES, Yoon HY, Kim CH, Goo YT, Kang MJ, Lee S, Lee BS, Jeon HR, Oh CH, Choi YW

Drug Design, Development and Therapy 2018, 12:3377-3392

Published Date: 9 October 2018

Utility of nintedanib for severe idiopathic pulmonary fibrosis: a single-center retrospective study

Abe M, Tsushima K, Sakayori M, Suzuki K, Ikari J, Terada J, Tatsumi K

Drug Design, Development and Therapy 2018, 12:3369-3375

Published Date: 9 October 2018

Indirubin suppresses ovarian cancer cell viabilities through the STAT3 signaling pathway

Chen L, Wang J, Wu J, Zheng Q, Hu J

Drug Design, Development and Therapy 2018, 12:3335-3342

Published Date: 4 October 2018

Evaluation of methotrexate-conjugated gadolinium(III) for cancer diagnosis and treatment

Xu D, Lu ST, Li YS, Baidya A, Mei H, He Y, Wu B

Drug Design, Development and Therapy 2018, 12:3301-3309

Published Date: 5 October 2018

Effect of butorphanol on opioid-induced cough: a meta-analysis of randomized controlled trials

Zhang J, Miao S, Tu Q, Shi M, Zou L, Liu S, Wang G

Drug Design, Development and Therapy 2018, 12:3263-3268

Published Date: 2 October 2018

Baicalin suppresses proliferation, migration, and invasion in human glioblastoma cells via Ca2+-dependent pathway

Zhu Y, Fang J, Wang H, Fei M, Tang T, Liu K, Niu W, Zhou Y

Drug Design, Development and Therapy 2018, 12:3247-3261

Published Date: 2 October 2018

Copper-64: a real theranostic agent

Gutfilen B, Souza SAL, Valentini G

Drug Design, Development and Therapy 2018, 12:3235-3245

Published Date: 2 October 2018

Lactobacilli with superoxide dismutase-like or catalase activity are more effective in alleviating inflammation in an inflammatory bowel disease mouse model

Tomusiak-Plebanek A, Heczko P, Skowron B, Baranowska A, Okoń K, Thor PJ, Strus M

Drug Design, Development and Therapy 2018, 12:3221-3233

Published Date: 28 September 2018

Synergistic combination therapy of lung cancer using paclitaxel- and triptolide-coloaded lipid–polymer hybrid nanoparticles

Liu J, Cheng H, Han L, Qiang Z, Zhang X, Gao W, Zhao K, Song Y

Drug Design, Development and Therapy 2018, 12:3199-3209

Published Date: 25 September 2018

Colorectal cancer combination therapy using drug and gene co-delivered, targeted poly(ethylene glycol)-ε-poly(caprolactone) nanocarriers

Wang Z, Wei Y, Fang G, Hong D, An L, Jiao T, Shi Y, Zang A

Drug Design, Development and Therapy 2018, 12:3171-3180

Published Date: 24 September 2018

Intravenous tranexamic acid use in revision total joint arthroplasty: a meta-analysis

Kuo FC, Lin PY, Wang JW, Lin PC, Lee MS, Chen AF

Drug Design, Development and Therapy 2018, 12:3163-3170

Published Date: 24 September 2018

Current development of biodegradable polymeric materials for biomedical applications

Song R, Murphy M, Li C, Ting K, Soo C, Zheng Z

Drug Design, Development and Therapy 2018, 12:3117-3145

Published Date: 24 September 2018

A targeted therapy for melanoma by graphene oxide composite with microRNA carrier

Liu C, Xie H, Yu JG, Chen X, Tang S, Sun L, Chen X, Peng D, Zhang X, Zhou J

Drug Design, Development and Therapy 2018, 12:3095-3106

Published Date: 21 September 2018

Comparison of the efficacy and survival analysis of neoadjuvant chemotherapy for Her-2-positive breast cancer

Li S, Wei W, Jiang Y, Li Q, Huang Q, Yang H, Liu J

Drug Design, Development and Therapy 2018, 12:3085-3093

Published Date: 21 September 2018

Effects of hydroxyethyl starch 130/0.4 on the kidney tissue of rats with ureteral obstruction

Güneş I, Süngü N, Kılıçarslan A, Şıvgın V, Alkan M, Küçük A, Boyunağa H, Ünal Y, Arslan M

Drug Design, Development and Therapy 2018, 12:3061-3070

Published Date: 20 September 2018

Chemotherapeutic drug targeting to lungs by way of microspheres after intravenous administration

Sangi S, SreeHarsha N, Bawadekji A, Al Ali M

Drug Design, Development and Therapy 2018, 12:3051-3060

Published Date: 18 September 2018

Sintered dicalcium pyrophosphate treatment attenuates estrogen deficiency-associated disc degeneration in ovariectomized rats

Chen CH, Chen WC, Lin CY, Chen CH, Tsuang YH, Kuo YJ

Drug Design, Development and Therapy 2018, 12:3033-3041

Published Date: 18 September 2018

Zoledronate inhibits fibroblasts’ proliferation and activation via targeting TGF-β signaling pathway

Zhao Z, Shen W, Zhu H, Lin L, Jiang G, Zhu Y, Song H, Wu L

Drug Design, Development and Therapy 2018, 12:3021-3031

Published Date: 17 September 2018

Novel anti-inflammatory film as a delivery system for the external medication with bioactive phytochemical “Apocynin”

Anter HM, Abu Hashim II, Awadin W, Meshali MM

Drug Design, Development and Therapy 2018, 12:2981-3001

Published Date: 13 September 2018

Astragaloside IV represses high glucose-induced mesangial cells activation by enhancing autophagy via SIRT1 deacetylation of NF-κB P65 subunit

Wang X, Gao Y, Tian N, Zhu Z, Wang T, Xu J, Wu B, Zhang N

Drug Design, Development and Therapy 2018, 12:2971-2980

Published Date: 12 September 2018

Saikosaponin A modulates remodeling of Kv4.2-mediated A-type voltage-gated potassium currents in rat chronic temporal lobe epilepsy

Hong Y, Deng N, Jin H, Xuan Z, Qian YX, Wu ZY, Xie W

Drug Design, Development and Therapy 2018, 12:2945-2958

Published Date: 11 September 2018

GlycoPEGylated recombinant factor IX for hemophilia B in context

Santagostino E, Mancuso ME

Drug Design, Development and Therapy 2018, 12:2933-2943

Published Date: 11 September 2018

Papaverine hydrochloride containing nanostructured lyotropic liquid crystal formulation as a potential drug delivery system for the treatment of erectile dysfunction

Berkó S, Zsikó S, Deák G, Gácsi A, Kovács A, Budai-Szűcs M, Pajor L, Bajory Z, Csányi E

Drug Design, Development and Therapy 2018, 12:2923-2931

Published Date: 12 September 2018

In vitro and in vivo evaluation of cephalosporins for the treatment of Lyme disease

Pothineni VR, Parekh MB, Babar MM, Ambati A, Maguire P, Inayathullah M, Kim K, Tayebi L, Potula HS, Rajadas J

Drug Design, Development and Therapy 2018, 12:2915-2921

Published Date: 11 September 2018

Chemopreventive activity of sulforaphane

Jiang X, Liu Y, Ma L, Ji R, Qu Y, Xin Y, Lv G

Drug Design, Development and Therapy 2018, 12:2905-2913

Published Date: 11 September 2018

Inhibitor of IGF1 receptor alleviates the inflammation process in the diabetic kidney mouse model without activating SOCS2

Li J, Dong R, Yu J, Yi S, Da J, Yu F, Zha Y

Drug Design, Development and Therapy 2018, 12:2887-2896

Published Date: 11 September 2018

Eremomycin pyrrolidide: a novel semisynthetic glycopeptide with improved chemotherapeutic properties

Olsufyeva EN, Shchekotikhin AE, Bychkova EN, Pereverzeva ER, Treshalin ID, Mirchink EP, Isakova EB, Chernobrovkin MG, Kozlov RS, Dekhnich AV, Preobrazhenskaya MN

Drug Design, Development and Therapy 2018, 12:2875-2885

Published Date: 10 September 2018

Profile of atezolizumab in the treatment of metastatic non-small-cell lung cancer: patient selection and perspectives

Facchinetti F, Bordi P, Leonetti A, Buti S, Tiseo M

Drug Design, Development and Therapy 2018, 12:2857-2873

Published Date: 10 September 2018

Macrocyclic lactones inhibit nasopharyngeal carcinoma cells proliferation through PAK1 inhibition and reduce in vivo tumor growth

Gallardo F, Mariamé B, Gence R, Tilkin-Mariamé AF

Drug Design, Development and Therapy 2018, 12:2805-2814

Published Date: 7 September 2018

The effect of food and liquid pH on the integrity of enteric-coated beads from cysteamine bitartrate delayed-release capsules

Pavloff N, Hauser TA, Williams C, Isbell SL, Cadieux B, Johnson M

Drug Design, Development and Therapy 2018, 12:2795-2804

Published Date: 6 September 2018

Efficacy and safety of a fixed-dose combination of nimesulide/pantoprazole compared to naproxen/esomeprazole for pain relief in patients with osteoarticular diseases and dyspeptic symptoms

Scheinberg M, Pott Júnior H, Macêdo EA, Bocchi de Oliveira MF, Ecclissato C, Amazonas RB

Drug Design, Development and Therapy 2018, 12:2775-2783

Published Date: 6 September 2018

Are laboratory parameter (biomarker) values similar to the healthy volunteer reference range in all patient populations?

Brott DA, Goodman MJ, Hermann RP, Merz M, Calvo R, Poorkhalkali N, Kiazand A

Drug Design, Development and Therapy 2018, 12:2757-2773

Published Date: 6 September 2018

Safety and efficacy of elbasvir/grazoprevir for the treatment of chronic hepatitis C: current evidence

Morikawa K, Nakamura A, Shimazaki T, Sakamoto N

Drug Design, Development and Therapy 2018, 12:2749-2756

Published Date: 5 September 2018

17β-estradiol ameliorates oxidative stress and blue light-emitting diode-induced retinal degeneration by decreasing apoptosis and enhancing autophagy

Wei Q, Liang X, Peng Y, Yu D, Zhang R, Jin H, Fan J, Cai W, Ren C, Yu J

Drug Design, Development and Therapy 2018, 12:2715-2730

Published Date: 4 September 2018

Fasudil inhibits actin polymerization and collagen synthesis and induces apoptosis in human urethral scar fibroblasts via the Rho/ROCK pathway

Li XD, Wu YP, Chen SH, Liang YC, Lin TT, Lin T, Wei Y, Xue XY, Zheng QS, Xu N

Drug Design, Development and Therapy 2018, 12:2707-2713

Published Date: 3 September 2018

The total alkaloids from Coptis chinensis Franch improve cognitive deficits in type 2 diabetic rats

Li JC, Shen XF, Shao JA, Tao MM, Gu J, Li J, Huang N

Drug Design, Development and Therapy 2018, 12:2695-2706

Published Date: 31 August 2018

Asenapine pharmacokinetics and tolerability in a pediatric population

Dogterom P, Riesenberg R, de Greef R, Dennie J, Johnson M, Pilla Reddy V, Miltenburg AMM, Findling RL, Jakate A, Carrothers TJ, Troyer MD

Drug Design, Development and Therapy 2018, 12:2677-2693

Published Date: 30 August 2018

Profile of pitolisant in the management of narcolepsy: design, development, and place in therapy

Romigi A, Vitrani G, Lo Giudice T, Centonze D, Franco V

Drug Design, Development and Therapy 2018, 12:2665-2675

Published Date: 30 August 2018

Inhibiting eEF-2 kinase-mediated autophagy enhanced the cytocidal effect of AKT inhibitor on human nasopharyngeal carcinoma

Zhao YY, Tian Y, Liu L, Zhan JH, Hou X, Chen X, Zhou T, Huang Y, Zhang L

Drug Design, Development and Therapy 2018, 12:2655-2663

Published Date: 29 August 2018

A novel multifunctional anti-CEA-IL15 molecule displays potent antitumor activities

Liu Y, Wang Y, Xing J, Li Y, Liu J, Wang Z

Drug Design, Development and Therapy 2018, 12:2645-2654

Published Date: 29 August 2018

Spectroscopic and molecular modeling studies of binding interaction between bovine serum albumin and roflumilast

Wani TA, Bakheit AH, Ansari MN, Al-Majed ARA, Al-Qahtani BM, Zargar S

Drug Design, Development and Therapy 2018, 12:2627-2634

Published Date: 28 August 2018

Fabrication and characterization of dexibuprofen nanocrystals using microchannel fluidic rector

Khan J, Bashir S, Khan MA, Mohammad MA, Isreb M

Drug Design, Development and Therapy 2018, 12:2617-2626

Published Date: 29 August 2018

Genetically engineered drug rhCNB induces apoptosis and cell cycle arrest in both gastric cancer cells and hepatoma cells

Guo Y, Huang Y, Tian S, Xie X, Xing G, Fu J

Drug Design, Development and Therapy 2018, 12:2567-2575

Published Date: 20 August 2018

MEK inhibitors for the treatment of NRAS mutant melanoma

Sarkisian S, Davar D

Drug Design, Development and Therapy 2018, 12:2553-2565

Published Date: 20 August 2018

Development of prednisolone-containing eye drop formulations by cyclodextrin complexation and antimicrobial, mucoadhesive biopolymer

Bíró T, Horvát G, Budai-Szűcs M, Csányi E, Urbán E, Facskó A, Szabó-Révész P, Csóka I, Aigner Z

Drug Design, Development and Therapy 2018, 12:2529-2537

Published Date: 15 August 2018

Current research for a vaccine against Lassa hemorrhagic fever virus

Warner BM, Safronetz D, Stein DR

Drug Design, Development and Therapy 2018, 12:2519-2527

Published Date: 14 August 2018

Baicalin provides neuroprotection in traumatic brain injury mice model through Akt/Nrf2 pathway

Fang J, Wang H, Zhou J, Dai W, Zhu Y, Zhou Y, Wang X, Zhou M

Drug Design, Development and Therapy 2018, 12:2497-2508

Published Date: 10 August 2018

Milnacipran poorly modulates pain in patients suffering from fibromyalgia: a randomized double-blind controlled study

Pickering G, Macian N, Delage N, Picard P, Cardot JM, Sickout-Arondo S, Giron F, Dualé C, Pereira B, Marcaillou F

Drug Design, Development and Therapy 2018, 12:2485-2496

Published Date: 10 August 2018

Preclinical safety evaluation of hepatic arterial infusion of oncolytic poxvirus

Cho E, Ryu EJ, Jiang F, Jeon UB, Cho M, Kim CH, Kim M, Kim ND, Hwang TH

Drug Design, Development and Therapy 2018, 12:2467-2474

Published Date: 8 August 2018

Systematic review and meta-analysis of the benefit of celecoxib in treating advanced non-small-cell lung cancer

Yi L, Zhang W, Zhang H, Shen J, Zou J, Luo P, Zhang J

Drug Design, Development and Therapy 2018, 12:2455-2466

Published Date: 7 August 2018

Antihyperlipidemic studies of newly synthesized phenolic derivatives: in silico and in vivo approaches

Aqeel MT, ur-Rahman N, Khan A, Ashraf Z, Latif M, Rafique H, Rasheed U

Drug Design, Development and Therapy 2018, 12:2443-2453

Published Date: 9 August 2018

Monitoring antiangiogenesis of bevacizumab in zebrafish

Zhang J, Gao BL, Zhang WC, Qian ZJ, Xiang Y

Drug Design, Development and Therapy 2018, 12:2423-2430

Published Date: 6 August 2018

Sinomenine inhibits the growth of melanoma by enhancement of autophagy via PI3K/AKT/mTOR inhibition

Sun Z, Zheng L, Liu X, Xing W, Liu X

Drug Design, Development and Therapy 2018, 12:2413-2421

Published Date: 6 August 2018

Zafirlukast in combination with pseudohypericin attenuates spinal cord injury and motor function in experimental mice

Chen XG, Hua F, Wang SG, Xu YY, Yue HT, Sun J

Drug Design, Development and Therapy 2018, 12:2389-2402

Published Date: 1 August 2018

Comparison of biosimilar filgrastim with a reference product: pharmacokinetics, pharmacodynamics, and safety profiles in healthy volunteers

Choi C, Yoo BW, Kim CO, Hong T, Jin BH, Seo KS, Jang JY, Park MS

Drug Design, Development and Therapy 2018, 12:2381-2387

Published Date: 1 August 2018

Pharmacological mechanism of roflumilast in the treatment of asthma–COPD overlap

Zhang X, Chen Y, Fan L, Ye J, Fan J, Xu X, You D, Liu S, Chen X, Luo P

Drug Design, Development and Therapy 2018, 12:2371-2379

Published Date: 1 August 2018

Doxorubicin-conjugated dexamethasone induced MCF-7 apoptosis without entering the nucleus and able to overcome MDR-1-induced resistance

Chaikomon K, Chattong S, Chaiya T, Tiwawech D, Sritana-Anant Y, Sereemaspun A, Manotham K

Drug Design, Development and Therapy 2018, 12:2361-2369

Published Date: 1 August 2018

Discovery of nonnucleoside inhibitors of polymerase from infectious pancreatic necrosis virus (IPNV)

Bello-Pérez M, Falco A, Galiano V, Coll J, Perez L, Encinar JA

Drug Design, Development and Therapy 2018, 12:2337-2359

Published Date: 30 July 2018

Role of janus kinase inhibitors in the treatment of alopecia areata

Triyangkulsri K, Suchonwanit P

Drug Design, Development and Therapy 2018, 12:2323-2335

Published Date: 27 July 2018

Care pathways and treatment patterns for patients with heart failure in China: results from a cross-sectional survey

Jackson JDS, Cotton SE, Bruce Wirta S, Proenca CC, Zhang M, Lahoz R, Balas B, Calado FJ

Drug Design, Development and Therapy 2018, 12:2311-2321

Published Date: 26 July 2018

Pharmacokinetic interaction between fimasartan and atorvastatin in healthy male volunteers

Choi Y, Lee S, Jang IJ, Yu KS

Drug Design, Development and Therapy 2018, 12:2301-2309

Published Date: 24 July 2018

Effects of the traditional Chinese medicine baicalein on the viability of random pattern skin flaps in rats

Lin R, Lin J, Li S, Ding J, Wu H, Xiang G, Li S, Huang Y, Lin D, Gao W, Kong J, Xu H, Zhou K

Drug Design, Development and Therapy 2018, 12:2267-2276

Published Date: 23 July 2018

The effects of bisphosphonates on osteoporotic patients after lumbar fusion: a meta-analysis

Liu WB, Zhao WT, Shen P, Zhang FJ

Drug Design, Development and Therapy 2018, 12:2233-2240

Published Date: 17 July 2018

Radiosensitivity enhancement by combined treatment of nimotuzumab and celecoxib on nasopharyngeal carcinoma cells

Huang JF, Yuan XP, Pang QF, Zhang HW, Yu JH, Yang B, Zhou LY, Zhang FZ, Liu FJ

Drug Design, Development and Therapy 2018, 12:2223-2231

Published Date: 16 July 2018

Emodin mitigates podocytes apoptosis induced by endoplasmic reticulum stress through the inhibition of the PERK pathway in diabetic nephropathy

Tian N, Gao Y, Wang X, Wu X, Zou D, Zhu Z, Han ZJ, Wang T, Shi Y

Drug Design, Development and Therapy 2018, 12:2195-2211

Published Date: 13 July 2018

Antifungal activity of Cardiospermum halicacabum L. (Sapindaceae) against Trichophyton rubrum occurs through molecular interaction with fungal Hsp90

Gaziano R, Campione E, Iacovelli F, Marino D, Pica F, Di Francesco P, Aquaro S, Menichini F, Falconi M, Bianchi L

Drug Design, Development and Therapy 2018, 12:2185-2193

Published Date: 12 July 2018

A case report of toxic epidermal necrolysis associated with AZD-9291

Wang J, Cheng XY, Lu Y, Zhou BR

Drug Design, Development and Therapy 2018, 12:2163-2167

Published Date: 11 July 2018

Effect of green tea catechins on the pharmacokinetics of digoxin in humans

Kim TE, Shin KH, Park JE, Kim MG, Yun YM, Choi DH, Kwon KJ, Lee J

Drug Design, Development and Therapy 2018, 12:2139-2147

Published Date: 10 July 2018

Development of a tin oxide carrier with mesoporous structure for improving the dissolution rate and oral relative bioavailability of fenofibrate

Bai A, Wu C, Liu X, Lv H, Xu X, Cao Y, Shang W, Hu L, Liu Y

Drug Design, Development and Therapy 2018, 12:2129-2138

Published Date: 10 July 2018

Self-nanomicellizing solid dispersion of edaravone: part II: in vivo assessment of efficacy against behavior deficits and safety in Alzheimer’s disease model

Parikh A, Kathawala K, Li JT, Chen C, Shan Z, Cao X, Wang YJ, Garg S, Zhou XF

Drug Design, Development and Therapy 2018, 12:2111-2128

Published Date: 9 July 2018

Design and development of ICCA as a dual inhibitor of GPIIb/IIIa and P-selectin receptors

Chen H, Lu A, Zhang X, Gui L, Wang YN, Wu J, Feng H, Peng S, Zhao M

Drug Design, Development and Therapy 2018, 12:2097-2110

Published Date: 9 July 2018

Safety and efficacy of durvalumab (MEDI4736) in various solid tumors

Yang H, Shen K, Zhu C, Li Q, Zhao Y, Ma X

Drug Design, Development and Therapy 2018, 12:2085-2096

Published Date: 6 July 2018

Self-nanomicellizing solid dispersion of edaravone: part I – oral bioavailability improvement

Parikh A, Kathawala K, Tan CC, Garg S, Zhou XF

Drug Design, Development and Therapy 2018, 12:2051-2069

Published Date: 5 July 2018

Antiangiogenic cytokines as potential new therapeutic targets for resveratrol in diabetic retinopathy

Popescu M, Bogdan C, Pintea A, Rugină D, Ionescu C

Drug Design, Development and Therapy 2018, 12:1985-1996

Published Date: 3 July 2018

Pharmacokinetics of placental protein 13 after intravenous and subcutaneous administration in rabbits

Drobnjak T, Meiri H, Mandalà M, Huppertz B, Gizurarson S

Drug Design, Development and Therapy 2018, 12:1977-1983

Published Date: 3 July 2018

Gemcitabine hydrochloride microspheres used for intravesical treatment of superficial bladder cancer: a comprehensive in vitro/ex vivo/in vivo evaluation

Karavana SY, Ay Şenyiğit Z, Çalışkan Ç, Sevin G, İlem Özdemir D, Erzurumlu Y, Şen S, Baloğlu E

Drug Design, Development and Therapy 2018, 12:1959-1975

Published Date: 2 July 2018

Daptomycin: a comparison of two intravenous formulations

Frankenfeld C, Mittal S, Melendez Y, Mendez-Vigo L, Lamp KC, Keller KN, Bertolami SR

Drug Design, Development and Therapy 2018, 12:1953-1958

Published Date: 29 June 2018

Mechanism of Yanghe Pingchuan granules treatment for airway remodeling in asthma

Pan LY, Han YQ, Wang YZ, Chen QQ, Wu Y, Sun Y

Drug Design, Development and Therapy 2018, 12:1941-1951

Published Date: 27 June 2018

Electroporation-enhanced transdermal diclofenac sodium delivery into the knee joint in a rat model of acute arthritis

Hartmann P, Butt E, Fehér Á, Szilágyi ÁL, Jász KD, Balázs B, Bakonyi M, Berkó S, Erős G, Boros M, Horváth G, Varga E, Csányi E

Drug Design, Development and Therapy 2018, 12:1917-1930

Published Date: 27 June 2018

The mechanism of botulinum A on Raynaud syndrome

Zhou Y, Liu Y, Hao Y, Feng Y, Pan L, Liu W, Li B, Xiao L, Jin L, Nie Z

Drug Design, Development and Therapy 2018, 12:1905-1915

Published Date: 26 June 2018

Modes of cell death induced by tetrahydroisoquinoline-based analogs in MDA-MB-231 breast and A549 lung cancer cell lines

Nel M, Joubert AM, Dohle W, Potter BVL, Theron AE

Drug Design, Development and Therapy 2018, 12:1881-1904

Published Date: 25 June 2018

Additive effect of oral LDD175 to tamsulosin and finasteride in a benign prostate hyperplasia rat model

Choi BR, Kim HK, Soni KK, Karna KK, Lee SW, So I, Park JK

Drug Design, Development and Therapy 2018, 12:1855-1863

Published Date: 22 June 2018

Salidroside ameliorates autophagy and activation of hepatic stellate cells in mice via NF-κB and TGF-β1/Smad3 pathways

Feng J, Chen K, Xia Y, Wu L, Li J, Li S, Wang W, Lu X, Liu T, Guo C

Drug Design, Development and Therapy 2018, 12:1837-1853

Published Date: 22 June 2018

Sevoflurane anaesthesia during pregnancy in mice induces hearing impairment in the offspring

Shen X, Xiao Y, Li W, Chen K, Yu H

Drug Design, Development and Therapy 2018, 12:1827-1836

Published Date: 22 June 2018

Use of levosimendan in the treatment of cerebral vascular vasospasm: a case study

Onichimowski D, Nosek K, Goraj R, Jalali R, Wińska A, Pawlos A, Tuyakov B

Drug Design, Development and Therapy 2018, 12:1777-1783

Published Date: 20 June 2018

Clinical efficacy of nab-paclitaxel in patients with metastatic pancreatic cancer

De Luca R, Blasi L, Alù M, Gristina V, Cicero G

Drug Design, Development and Therapy 2018, 12:1769-1775

Published Date: 19 June 2018

Linezolid: a review of its properties, function, and use in critical care

Hashemian SMR, Farhadi T, Ganjparvar M

Drug Design, Development and Therapy 2018, 12:1759-1767

Published Date: 18 June 2018

Lights and shadows of NSAIDs in bone healing: the role of prostaglandins in bone metabolism

Lisowska B, Kosson D, Domaracka K

Drug Design, Development and Therapy 2018, 12:1753-1758

Published Date: 18 June 2018

Annatto-derived tocotrienol stimulates osteogenic activity in preosteoblastic MC3T3-E1 cells: a temporal sequential study

Wan Hasan WN, Abd Ghafar N, Chin KY, Ima-Nirwana S

Drug Design, Development and Therapy 2018, 12:1715-1726

Published Date: 13 June 2018

Effect of food on the pharmacokinetic characteristics of a single oral dose of LCB01-0371, a novel oxazolidinone antibiotic

Sunwoo J, Kim YK, Choi Y, Yu KS, Nam H, Cho YL, Yoon S, Chung JY

Drug Design, Development and Therapy 2018, 12:1707-1714

Published Date: 11 June 2018

Chloroquine and hydroxychloroquine are associated with reduced cardiovascular risk: a systematic review and meta-analysis

Liu D, Li X, Zhang Y, Kwong JSW, Li L, Zhang Y, Xu C, Li Q, Sun X, Tian H, Li S

Drug Design, Development and Therapy 2018, 12:1685-1695

Published Date: 11 June 2018

Burden of heart failure on caregivers in China: results from a cross-sectional survey

Jackson JDS, Cotton SE, Bruce Wirta S, Proenca CC, Zhang M, Lahoz R, Calado FJ

Drug Design, Development and Therapy 2018, 12:1669-1678

Published Date: 8 June 2018

Burden of heart failure on patients from China: results from a cross-sectional survey

Jackson JDS, Cotton SE, Bruce Wirta S, Proenca CC, Zhang M, Lahoz R, Calado FJ

Drug Design, Development and Therapy 2018, 12:1659-1668

Published Date: 8 June 2018

AMPK/AS160 mediates tiliroside derivatives-stimulated GLUT4 translocation in muscle cells

Zhang C, Jiang Y, Liu J, Jin M, Qin N, Chen Y, Niu W, Duan H

Drug Design, Development and Therapy 2018, 12:1581-1587

Published Date: 1 June 2018

Optimization of a combined wet milling process in order to produce poly(vinyl alcohol) stabilized nanosuspension

Bartos C, Jójárt-Laczkovich O, Katona G, Budai-Szűcs M, Ambrus R, Bocsik A, Gróf I, Deli MA, Szabó-Révész P

Drug Design, Development and Therapy 2018, 12:1567-1580

Published Date: 31 May 2018

2-Amino-1,3,4-thiadiazole as a potential scaffold for promising antimicrobial agents

Serban G, Stanasel O, Serban E, Bota S

Drug Design, Development and Therapy 2018, 12:1545-1566

Published Date: 31 May 2018

Formulation and in vitro characterization of rifampicin-loaded porous poly (ε-caprolactone) microspheres for sustained skeletal delivery

Mei Q, Luo P, Zuo Y, Li J, Zou Q, Li Y, Jiang D, Wang Y

Drug Design, Development and Therapy 2018, 12:1533-1544

Published Date: 31 May 2018

Incidence and risk of cardiac toxicities in patients with relapsed and refractory multiple myeloma treated with carfilzomib

Zhao F, Yang B, Wang J, Zhang R, Liu J, Yin F, Xu W, He C

Drug Design, Development and Therapy 2018, 12:1525-1531

Published Date: 30 May 2018

Spotlight on olaparib in the treatment of BRCA-mutated ovarian cancer: design, development and place in therapy

Lorusso D, Tripodi E, Maltese G, Lepori S, Sabatucci I, Bogani G, Raspagliesi F

Drug Design, Development and Therapy 2018, 12:1501-1509

Published Date: 29 May 2018

Pharmacological activities, mechanisms of action, and safety of salidroside in the central nervous system

Zhong ZF, Han J, Zhang JZ, Xiao Q, Hu J, Chen LD

Drug Design, Development and Therapy 2018, 12:1479-1489

Published Date: 24 May 2018

Synthesis and evaluation of ortho-[18F]fluorocelecoxib for COX-2 cholangiocarcinoma imaging

Chang CW, Yeh CN, Chung YH, Chen YR, Tien SW, Chen TW, Farn SS, Huang YC, Yu CS

Drug Design, Development and Therapy 2018, 12:1467-1478

Published Date: 24 May 2018

nab-Paclitaxel/carboplatin in elderly patients with advanced squamous non-small cell lung cancer: a retrospective analysis of a Phase III trial

Gridelli C, Chen T, Ko A, O'Brien ME, Ong TJ, Socinski MA, Postmus PE

Drug Design, Development and Therapy 2018, 12:1445-1451

Published Date: 24 May 2018

In silico and in vivo characterization of cabralealactone, solasodin and salvadorin in a rat model: potential anti-inflammatory agents

Malik A, Arooj M, Butt TT, Zahid S, Zahid F, Jafar TH, Waquar S, Gan SH, Ahmad S, Mirza MU

Drug Design, Development and Therapy 2018, 12:1431-1443

Published Date: 24 May 2018

The anti-cataract molecular mechanism study in selenium cataract rats for baicalin ophthalmic nanoparticles

Li N, Han Z, Li L, Zhang B, Liu Z, Li J

Drug Design, Development and Therapy 2018, 12:1399-1411

Published Date: 23 May 2018

Effects of hemocoagulase agkistrodon on the coagulation factors and its procoagulant activities

Li H, Huang Y, Wu X, Wu T, Cao Y, Wang Q, Qiu Y, Fu W, Zhang Q, Pang J

Drug Design, Development and Therapy 2018, 12:1385-1398

Published Date: 23 May 2018

Antihyperglycemic and anti-inflammatory effects of fermented food paste in high-fat diet and streptozotocin-challenged mice

Zulkawi N, Ng KH, Zamberi NR, Yeap SK, Satharasinghe DA, Tan SW, Ho WY, Abd Rashid NY, Md Lazim MI, Jamaluddin A, Alitheen NB, Long K

Drug Design, Development and Therapy 2018, 12:1373-1383

Published Date: 23 May 2018

REST, not REST4, is a risk factor associated with radiotherapy plus chemotherapy efficacy in glioma

Li C, Zou H, Wang ZF, Tang X, Fan X, Zhang K, Liu J, Li Z

Drug Design, Development and Therapy 2018, 12:1363-1371

Published Date: 22 May 2018

Immature platelets and antiplatelet therapy response to aspirin in Kawasaki disease

Pi L, Che D, Long HF, Fang ZZ, Li JW, Lin SY, Liu YF, Li M, Bao LJ, Li W, Zhang Y, Deng QL, Liu TC, Zhang L, Gu XQ

Drug Design, Development and Therapy 2018, 12:1353-1362

Published Date: 23 May 2018

Assessment of the effects of levosimendan and thymoquinone on lung injury after myocardial ischemia reperfusion in rats

Sezen SC, Kucuk A, Özer A, Kılıç Y, Mardin B, Alkan M, Erkent FD, Arslan M, Ünal Y, Oktar GL, Tosun M

Drug Design, Development and Therapy 2018, 12:1347-1352

Published Date: 22 May 2018

Design and preparation of derivatives of oleanolic and glycyrrhetinic acids with cytotoxic properties

Wang R, Li Y, Huai XD, Zheng QX, Wang W, Li HJ, Huai QY

Drug Design, Development and Therapy 2018, 12:1321-1336

Published Date: 21 May 2018

Glycyrrhizic acid ameliorates myocardial ischemic injury by the regulation of inflammation and oxidative state

Xu CL, Liang CH, Sun WX, Chen JD, Chen XH

Drug Design, Development and Therapy 2018, 12:1311-1319

Published Date: 18 May 2018

Vicenin-2 inhibits Wnt/β-catenin signaling and induces apoptosis in HT-29 human colon cancer cell line

Yang D, Zhang X, Zhang W, Rengarajan T

Drug Design, Development and Therapy 2018, 12:1303-1310

Published Date: 18 May 2018

Rapeseed protein-derived antioxidant peptide RAP alleviates renal fibrosis through MAPK/NF-κB signaling pathways in diabetic nephropathy

Zhang M, Yan Z, Bu L, An C, Wang D, Liu X, Zhang J, Yang W, Deng BC, Xie J, Zhang B

Drug Design, Development and Therapy 2018, 12:1255-1268

Published Date: 15 May 2018

Computer-aided design of amino acid-based therapeutics: a review

Farhadi T, Hashemian SM

Drug Design, Development and Therapy 2018, 12:1239-1254

Published Date: 14 May 2018

Semen Brassicae ameliorates hepatic fibrosis by regulating transforming growth factor-β1/Smad, nuclear factor-κB, and AKT signaling pathways in rats

Cao S, Zheng B, Chen T, Chang X, Yin B, Huang ZH, Shuai P, Han L

Drug Design, Development and Therapy 2018, 12:1205-1213

Published Date: 11 May 2018

Schisandrin B ameliorated chondrocytes inflammation and osteoarthritis via suppression of NF-κB and MAPK signal pathways

Ran J, Ma C, Xu K, Xu L, He Y, Moqbel SAA, Hu P, Jiang L, Chen W, Bao J, Xiong Y, Wu L

Drug Design, Development and Therapy 2018, 12:1195-1204

Published Date: 9 May 2018

Insight into resistance mechanism of anaplastic lymphoma kinase to alectinib and JH-VIII-157-02 caused by G1202R solvent front mutation

Wang H, Wang Y, Guo W, Du B, Huang X, Wu R, Yang B, Lin X, Wu Y

Drug Design, Development and Therapy 2018, 12:1183-1193

Published Date: 9 May 2018

The cytochrome P450 isoenzyme and some new opportunities for the prediction of negative drug interaction in vivo

Sychev DA, Ashraf GM, Svistunov AA, Maksimov ML, Tarasov VV, Chubarev VN, Otdelenov VA, Denisenko NP, Barreto GE, Aliev G

Drug Design, Development and Therapy 2018, 12:1147-1156

Published Date: 8 May 2018

Identification of Mycobacterium tuberculosis BioA inhibitors by using structure-based virtual screening

Singh S, Khare G, Bahal RK, Ghosh PC, Tyagi AK

Drug Design, Development and Therapy 2018, 12:1065-1079

Published Date: 1 May 2018

Inactivation of nuclear factor κB by MIP-based drug combinations augments cell death of breast cancer cells

Subramaniam M, Liew SK, In LLA, Awang K, Ahmed N, Nagoor NH

Drug Design, Development and Therapy 2018, 12:1053-1063

Published Date: 1 May 2018

Pharmacokinetic characteristics of telaprevir in healthy Korean male subjects and comparisons with Japanese

Choi Y, Yoon S, Matsumoto K, Ohta Y, Lee S, Yu KS, Jang IJ

Drug Design, Development and Therapy 2018, 12:1045-1051

Published Date: 30 April 2018

Spotlight on isavuconazole in the treatment of invasive aspergillosis and mucormycosis: design, development, and place in therapy

Jenks JD, Salzer HJ, Prattes J, Krause R, Buchheidt D, Hoenigl M

Drug Design, Development and Therapy 2018, 12:1033-1044

Published Date: 30 April 2018

Symmetric dimeric adamantanes for exploring the structure of two viroporins: influenza virus M2 and hepatitis C virus p7

Mandour YM, Breitinger U, Ma C, Wang J, Boeckler FM, Breitinger HG, Zlotos DP

Drug Design, Development and Therapy 2018, 12:1019-1031

Published Date: 30 April 2018

Astragalus polysaccharides protect cardiac stem and progenitor cells by the inhibition of oxidative stress-mediated apoptosis in diabetic hearts

Chen W, Ju J, Yang Y, Wang H, Chen W, Zhao X, Ye H, Zhang Y

Drug Design, Development and Therapy 2018, 12:943-954

Published Date: 20 April 2018

Comparison of tadalafil pharmacokinetics after administration of a new orodispersible film versus a film-coated tablet

Park SI, Heo SH, Kim G, Chang S, Song KH, Kim MG, Jin EH, Kim J, Lee S, Hong JH

Drug Design, Development and Therapy 2018, 12:935-942

Published Date: 20 April 2018

Chitosan–alginate BSA-gel-capsules for local chemotherapy against drug-resistant breast cancer

Shen H, Li F, Wang D, Yang Z, Yao C, Ye Y, Wang X

Drug Design, Development and Therapy 2018, 12:921-934

Published Date: 19 April 2018

Design, synthesis, and structure–activity relationships of 2-benzylidene-1-indanone derivatives as anti-inflammatory agents for treatment of acute lung injury

Xiao S, Zhang W, Chen H, Fang B, Qiu Y, Chen X, Chen L, Shu S, Zhang Y, Zhao Y, Liu Z, Liang G

Drug Design, Development and Therapy 2018, 12:887-899

Published Date: 19 April 2018

Population pharmacokinetics and dosing optimization of cefathiamidine in children with hematologic infection

Zhi LJ, Wang L, Chen XK, Zhai XY, Wen L, Dong L, Jacqz-Aigrain E, Shi ZR, Zhao W

Drug Design, Development and Therapy 2018, 12:855-862

Published Date: 17 April 2018

Reevaluation of the post-marketing safety of Shuxuening injection based on real-world and evidence-based evaluations

Wang C, Shi QP, Ding F, Jiang XD, Tang W, Yu ML, Zhu JH

Drug Design, Development and Therapy 2018, 12:757-767

Published Date: 5 April 2018

Chrysin suppresses proliferation, migration, and invasion in glioblastoma cell lines via mediating the ERK/Nrf2 signaling pathway

Wang J, Wang HD, Sun KJ, Wang XL, Pan H, Zhu JH, Ji XJ, Li X

Drug Design, Development and Therapy 2018, 12:721-733

Published Date: 3 April 2018

Preparation and in vitro/in vivo evaluation of PLGA microspheres containing norquetiapine for long-acting injection

Park CW, Lee HJ, Oh DW, Kang JH, Han CS, Kim DW

Drug Design, Development and Therapy 2018, 12:711-719

Published Date: 5 April 2018

Organic mononitrites of 1,2-propanediol act as an effective NO-releasing vasodilator in pulmonary hypertension and exhibit no cross-tolerance with nitroglycerin in anesthetized pigs

Nilsson KF, Goździk W, Frostell C, Zieliński S, Zielińska M, Ratajczak K, Skrzypczak P, Rodziewicz S, Albert J, Gustafsson LE

Drug Design, Development and Therapy 2018, 12:685-694

Published Date: 29 March 2018

The role of propranolol as a radiosensitizer in gastric cancer treatment

Liao XH, Chaudhary P, Qiu G, Che XM, Fan L

Drug Design, Development and Therapy 2018, 12:639-645

Published Date: 28 March 2018

Benralizumab in the treatment of severe asthma: design, development and potential place in therapy

Pelaia C, Vatrella A, Bruni A, Terracciano R, Pelaia G

Drug Design, Development and Therapy 2018, 12:619-628

Published Date: 21 March 2018

Rucaparib: a novel PARP inhibitor for BRCA advanced ovarian cancer

Colombo I, Lheureux S, Oza AM

Drug Design, Development and Therapy 2018, 12:605-617

Published Date: 21 March 2018

Tendinopathy: injury, repair, and current exploration

Lipman K, Wang CC, Ting K, Soo C, Zheng Z

Drug Design, Development and Therapy 2018, 12:591-603

Published Date: 20 March 2018

The hydroxypropyl–β-cyclodextrin complexation of toltrazuril for enhancing bioavailability

Zhang L, Liu MX, Lu CC, Ren DD, Fan GQ, Liu C, Liu MJ, Shu G, Peng GN, Yuan ZX, Zhong ZJ, Zhang W, Fu HL

Drug Design, Development and Therapy 2018, 12:583-589

Published Date: 19 March 2018

Bioequivalence of a biosimilar enoxaparin sodium to Clexane® after single 100 mg subcutaneous dose: results of a randomized, double-blind, crossover study in healthy volunteers

Martínez González J, Monreal M, Ayani Almagia I, Llaudó Garín J, Ochoa Díaz de Monasterioguren L, Gutierro Adúriz I

Drug Design, Development and Therapy 2018, 12:575-582

Published Date: 19 March 2018

Pharmacokinetic and bioequivalence study of a telmisartan/S-amlodipine fixed-dose combination (CKD-828) formulation and coadministered telmisartan and S-amlodipine in healthy subjects

Kang WY, Seong SJ, Ohk B, Gwon M, Kim BK, La S, Kim HJ, Cho S, Yoon Y, Yang DH, Lee HW

Drug Design, Development and Therapy 2018, 12:545-553

Published Date: 14 March 2018

Involvement of NF-κB and HSP70 signaling pathways in the apoptosis of MDA-MB-231 cells induced by a prenylated xanthone compound, α-mangostin, from Cratoxylum arborescens [Corrigendum] [Retraction]

Ibrahim MY, Mohd Hashim N, Mohan S, Mohd Ali H, Abdelwahab S, Kamalidehghan B, Ghaderian M, Dehghan F, Salim LZ, Karimian H, Yahayu M, Ee Cheng Lian G, Abdulla M, Farjam AS

Drug Design, Development and Therapy 2018, 12:533-534

Published Date: 13 March 2018

Can dexmedetomidine reduce atrial fibrillation after cardiac surgery? A systematic review and meta-analysis

Zhu ZP, Zhou HM, Ni YJ, Wu C, Zhang CJ, Ling XY

Drug Design, Development and Therapy 2018, 12:521-531

Published Date: 12 March 2018

Inhibitory effect of celecoxib on agomelatine metabolism in vitro and in vivo

He JY, Fang P, Zheng X, Wang CC, Liu TH, Zhang BW, Wen J, Xu RA

Drug Design, Development and Therapy 2018, 12:513-519

Published Date: 9 March 2018

Development of small bisquaternary cholinesterase inhibitors as drugs for pre-treatment of nerve agent poisonings

Kuca K, Karasova JZ, Soukup O, Kassa J, Novotna E, Sepsova V, Horova A, Pejchal J, Hrabinova M, Vodakova E, Jun D, Nepovimova E, Valis M, Musilek K

Drug Design, Development and Therapy 2018, 12:505-512

Published Date: 9 March 2018

Synovial tissue quantitative proteomics analysis reveals paeoniflorin decreases LIFR and ASPN proteins in experimental rheumatoid arthritis

Yang S, Xing ZH, Liu T, Zhou J, Liang QH, Tang T, Cui HJ, Peng WJ, Xiong XG, Wang Y

Drug Design, Development and Therapy 2018, 12:463-473

Published Date: 6 March 2018

Intra-articular platelet-rich plasma versus hyaluronic acid in the treatment of knee osteoarthritis: a meta-analysis

Zhang HF, Wang CG, Li H, Huang YT, Li ZJ

Drug Design, Development and Therapy 2018, 12:445-453

Published Date: 5 March 2018

Efficacy of atorvastatin on the prevention of contrast-induced acute kidney injury: a meta-analysis

Liu L, Liu Y, Wu M, Sun Y, Ma F

Drug Design, Development and Therapy 2018, 12:437-444

Published Date: 2 March 2018

Risk factors for calcineurin inhibitor nephrotoxicity after renal transplantation: a systematic review and meta-analysis

Xia T, Zhu S, Wen Y, Gao S, Li M, Tao X, Zhang F, Chen W

Drug Design, Development and Therapy 2018, 12:417-428

Published Date: 28 February 2018

Magnesium: does it reduce ischemia/reperfusion injury in an adnexal torsion rat model?

Celik Kavak E, Gulcu Bulmus F, Bulmus O, Kavak SB, Kocaman N

Drug Design, Development and Therapy 2018, 12:409-415

Published Date: 28 February 2018

Fasudil inhibits proliferation and migration of Hep-2 laryngeal carcinoma cells

Zhang X, Wu N

Drug Design, Development and Therapy 2018, 12:373-381

Published Date: 23 February 2018

Therapeutic potential of bimatoprost for the treatment of eyebrow hypotrichosis

Chanasumon N, Sriphojanart T, Suchonwanit P

Drug Design, Development and Therapy 2018, 12:365-372

Published Date: 22 February 2018

Formulation design and development of matrix diffusion controlled transdermal drug delivery of glimepiride

Akram MR, Ahmad M, Abrar A, Sarfraz RM, Mahmood A

Drug Design, Development and Therapy 2018, 12:349-364

Published Date: 21 February 2018

Short-term efficacy of intravitreal conbercept in treatment-naive patients with polypoidal choroidal vasculopathy

Peng Y, Zhang X, Li M, Liu B, Mi L, Zuo C, Wen F

Drug Design, Development and Therapy 2018, 12:339-345

Published Date: 19 February 2018

Pharmacokinetics and tolerability of eletriptan hydrobromide in healthy Korean subjects

Kim YK, Shin KH, Alderman J, Yu KS, Jang IJ, Lee S

Drug Design, Development and Therapy 2018, 12:331-337

Published Date: 19 February 2018

RETRACTED ARTICLE: Berberine nanoparticles with enhanced in vitro bioavailability: characterization and antimicrobial activity

Sahibzada MUK, Sadiq A, Faidah HS, Khurram M, Amin MU, Haseeb A, Kakar M

Drug Design, Development and Therapy 2018, 12:303-312

Published Date: 14 February 2018

Comparison of the long-term efficacy and safety of generic tacrolimus, Tacrobell, with Prograf in liver transplant recipients

Choi HJ, Kim DG, Kwak BJ, Han JH, Hong TH, You YK

Drug Design, Development and Therapy 2018, 12:295-301

Published Date: 13 February 2018

Asthma and poly(ADP-ribose) polymerase inhibition: a new therapeutic approach

Zaffini R, Gotte G, Menegazzi M

Drug Design, Development and Therapy 2018, 12:281-293

Published Date: 12 February 2018

Reference ranges for antiepileptic drugs revisited: a practical approach to establish national guidelines

Reimers A, Berg JA, Burns ML, Brodtkorb E, Johannessen SI, Johannessen Landmark C

Drug Design, Development and Therapy 2018, 12:271-280

Published Date: 8 February 2018

Experimental and molecular modeling approach to optimize suitable polymers for fabrication of stable fluticasone nanoparticles with enhanced dissolution and antimicrobial activity

Ahmed S, Govender T, Khan I, ur Rehman N, Ali W, Shah SMH, Khan S, Hussain Z, Ullah R, Alsaid MS

Drug Design, Development and Therapy 2018, 12:255-269

Published Date: 5 February 2018

Dysregulation of Neuregulin-1/ErbB signaling in the hippocampus of rats after administration of doxorubicin

Liao D, Guo Y, Xiang D, Dang R, Xu P, Cai H, Cao L, Jiang P

Drug Design, Development and Therapy 2018, 12:231-239

Published Date: 30 January 2018

Durvalumab: an investigational anti-PD-L1 monoclonal antibody for the treatment of urothelial carcinoma

Faiena I, Cummings AL, Crosetti AM, Pantuck AJ, Chamie K, Drakaki A

Drug Design, Development and Therapy 2018, 12:209-215

Published Date: 23 January 2018

Bispecific antibodies: design, therapy, perspectives

Sedykh SE, Prinz VV, Buneva VN, Nevinsky GA

Drug Design, Development and Therapy 2018, 12:195-208

Published Date: 22 January 2018

Anticonvulsant and reproductive toxicological studies of the imidazole-based histamine H3R antagonist 2-18 in mice

Bastaki SM, Abdulrazzaq YM, Shafiullah M, Więcek M, Kieć-Kononowicz K, Sadek B

Drug Design, Development and Therapy 2018, 12:179-194

Published Date: 19 January 2018

Involvement of microRNA-146a in diabetic peripheral neuropathy through the regulation of inflammation

Feng Y, Chen L, Luo Q, Wu M, Chen Y, Shi X

Drug Design, Development and Therapy 2018, 12:171-177

Published Date: 17 January 2018

Efficacy and side effects of intravenous theophylline in acute asthma: a systematic review and meta-analysis

Mahemuti G, Zhang H, Li J, Tieliwaerdi N, Ren L

Drug Design, Development and Therapy 2018, 12:99-120

Published Date: 10 January 2018

Peptides derived from Plasmodium falciparum leucine-rich repeat 1 bind to serine/threonine phosphatase type 1 and inhibit parasite growth in vitro

Pierrot C, Zhang X, Zanghi G, Fréville A, Rebollo A, Khalife J

Drug Design, Development and Therapy 2018, 12:85-88

Published Date: 9 January 2018

Quantitative assessment of the effects of chitosan intervention on blood pressure control

Huang H, Zou Y, Chi H

Drug Design, Development and Therapy 2018, 12:67-75

Published Date: 28 December 2017

The oral bioavailability, excretion and cytochrome P450 inhibition properties of epiberberine: an in vivo and in vitro evaluation

Chen N, Yang X, Guo C, Bi X, Chen J, Chen H, Li H, Lin H, Zhang Y

Drug Design, Development and Therapy 2018, 12:57-65

Published Date: 28 December 2017

Portulaca oleracea L. alleviates liver injury in streptozotocin-induced diabetic mice

Zheng G, Mo F, Ling C, Peng H, Gu W, Li M, Chen Z

Drug Design, Development and Therapy 2018, 12:47-55

Published Date: 28 December 2017

Clinical features of hypophosphatemic osteomalacia induced by long-term low-dose adefovir dipivoxil

Zhu S, Yang YH, Gao RW, Li R, Zou YZ, Feng L, Zhang B

Drug Design, Development and Therapy 2018, 12:41-45

Published Date: 27 December 2017

Leishmaniasis in humans: drug or vaccine therapy?

Ghorbani M, Farhoudi R

Drug Design, Development and Therapy 2018, 12:25-40

Published Date: 22 December 2017

Intra-articular collagenase injection increases range of motion in a rat knee flexion contracture model

Wong K, Trudel G, Laneuville O

Drug Design, Development and Therapy 2018, 12:15-24

Published Date: 21 December 2017

HX575: established biosimilarity in the treatment of renal anemia and 10 years of clinical experience

Dellanna F, Goldsmith D, Krendyukov A, Seidl A, Höbel N, Combe C

Drug Design, Development and Therapy 2018, 12:9-14

Published Date: 18 December 2017