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Drug Design, Development and Therapy


Archive: Volume 12, 2018

Design and preparation of derivatives of oleanolic and glycyrrhetinic acids with cytotoxic properties

Wang R, Li Y, Huai XD, Zheng QX, Wang W, Li HJ, Huai QY

Drug Design, Development and Therapy 2018, 12:1321-1336

Published Date: 21 May 2018

Glycyrrhizic acid ameliorates myocardial ischemic injury by the regulation of inflammation and oxidative state

Xu CL, Liang CH, Sun WX, Chen JD, Chen XH

Drug Design, Development and Therapy 2018, 12:1311-1319

Published Date: 18 May 2018

Vicenin-2 inhibits Wnt/β-catenin signaling and induces apoptosis in HT-29 human colon cancer cell line

Yang D, Zhang X, Zhang W, Rengarajan T

Drug Design, Development and Therapy 2018, 12:1303-1310

Published Date: 18 May 2018

Rapeseed protein-derived antioxidant peptide RAP alleviates renal fibrosis through MAPK/NF-κB signaling pathways in diabetic nephropathy

Zhang M, Yan Z, Bu L, An C, Wang D, Liu X, Zhang J, Yang W, Deng BC, Xie J, Zhang B

Drug Design, Development and Therapy 2018, 12:1255-1268

Published Date: 15 May 2018

Computer-aided design of amino acid-based therapeutics: a review

Farhadi T, Hashemian SM

Drug Design, Development and Therapy 2018, 12:1239-1254

Published Date: 14 May 2018

Semen Brassicae ameliorates hepatic fibrosis by regulating transforming growth factor-β1/Smad, nuclear factor-κB, and AKT signaling pathways in rats

Cao S, Zheng B, Chen T, Chang X, Yin B, Huang ZH, Shuai P, Han L

Drug Design, Development and Therapy 2018, 12:1205-1213

Published Date: 11 May 2018

Schisandrin B ameliorated chondrocytes inflammation and osteoarthritis via suppression of NF-κB and MAPK signal pathways

Ran J, Ma C, Xu K, Xu L, He Y, Moqbel SAA, Hu P, Jiang L, Chen W, Bao J, Xiong Y, Wu L

Drug Design, Development and Therapy 2018, 12:1195-1204

Published Date: 9 May 2018

Insight into resistance mechanism of anaplastic lymphoma kinase to alectinib and JH-VIII-157-02 caused by G1202R solvent front mutation

Wang H, Wang Y, Guo W, Du B, Huang X, Wu R, Yang B, Lin X, Wu Y

Drug Design, Development and Therapy 2018, 12:1183-1193

Published Date: 9 May 2018

The cytochrome P450 isoenzyme and some new opportunities for the prediction of negative drug interaction in vivo

Sychev DA, Ashraf GM, Svistunov AA, Maksimov ML, Tarasov VV, Chubarev VN, Otdelenov VA, Denisenko NP, Barreto GE, Aliev G

Drug Design, Development and Therapy 2018, 12:1147-1156

Published Date: 8 May 2018

Identification of Mycobacterium tuberculosis BioA inhibitors by using structure-based virtual screening

Singh S, Khare G, Bahal RK, Ghosh PC, Tyagi AK

Drug Design, Development and Therapy 2018, 12:1065-1079

Published Date: 1 May 2018

Inactivation of nuclear factor κB by MIP-based drug combinations augments cell death of breast cancer cells

Subramaniam M, Liew SK, In LLA, Awang K, Ahmed N, Nagoor NH

Drug Design, Development and Therapy 2018, 12:1053-1063

Published Date: 1 May 2018

Pharmacokinetic characteristics of telaprevir in healthy Korean male subjects and comparisons with Japanese

Choi Y, Yoon S, Matsumoto K, Ohta Y, Lee S, Yu KS, Jang IJ

Drug Design, Development and Therapy 2018, 12:1045-1051

Published Date: 30 April 2018

Spotlight on isavuconazole in the treatment of invasive aspergillosis and mucormycosis: design, development, and place in therapy

Jenks JD, Salzer HJ, Prattes J, Krause R, Buchheidt D, Hoenigl M

Drug Design, Development and Therapy 2018, 12:1033-1044

Published Date: 30 April 2018

Symmetric dimeric adamantanes for exploring the structure of two viroporins: influenza virus M2 and hepatitis C virus p7

Mandour YM, Breitinger U, Ma C, Wang J, Boeckler FM, Breitinger HG, Zlotos DP

Drug Design, Development and Therapy 2018, 12:1019-1031

Published Date: 30 April 2018

Astragalus polysaccharides protect cardiac stem and progenitor cells by the inhibition of oxidative stress-mediated apoptosis in diabetic hearts

Chen W, Ju J, Yang Y, Wang H, Chen W, Zhao X, Ye H, Zhang Y

Drug Design, Development and Therapy 2018, 12:943-954

Published Date: 20 April 2018

Comparison of tadalafil pharmacokinetics after administration of a new orodispersible film versus a film-coated tablet

Park SI, Heo SH, Kim G, Chang S, Song KH, Kim MG, Jin EH, Kim J, Lee S, Hong JH

Drug Design, Development and Therapy 2018, 12:935-942

Published Date: 20 April 2018

Chitosan–alginate BSA-gel-capsules for local chemotherapy against drug-resistant breast cancer

Shen H, Li F, Wang D, Yang Z, Yao C, Ye Y, Wang X

Drug Design, Development and Therapy 2018, 12:921-934

Published Date: 19 April 2018

Design, synthesis, and structure–activity relationships of 2-benzylidene-1-indanone derivatives as anti-inflammatory agents for treatment of acute lung injury

Xiao S, Zhang W, Chen H, Fang B, Qiu Y, Chen X, Chen L, Shu S, Zhang Y, Zhao Y, Liu Z, Liang G

Drug Design, Development and Therapy 2018, 12:887-899

Published Date: 19 April 2018

Population pharmacokinetics and dosing optimization of cefathiamidine in children with hematologic infection

Zhi LJ, Wang L, Chen XK, Zhai XY, Wen L, Dong L, Jacqz-Aigrain E, Shi ZR, Zhao W

Drug Design, Development and Therapy 2018, 12:855-862

Published Date: 17 April 2018

Reevaluation of the post-marketing safety of Shuxuening injection based on real-world and evidence-based evaluations

Wang C, Shi QP, Ding F, Jiang XD, Tang W, Yu ML, Zhu JH

Drug Design, Development and Therapy 2018, 12:757-767

Published Date: 5 April 2018

Chrysin suppresses proliferation, migration, and invasion in glioblastoma cell lines via mediating the ERK/Nrf2 signaling pathway

Wang J, Wang HD, Sun KJ, Wang XL, Pan H, Zhu JH, Ji XJ, Li X

Drug Design, Development and Therapy 2018, 12:721-733

Published Date: 3 April 2018

Preparation and in vitro/in vivo evaluation of PLGA microspheres containing norquetiapine for long-acting injection

Park CW, Lee HJ, Oh DW, Kang JH, Han CS, Kim DW

Drug Design, Development and Therapy 2018, 12:711-719

Published Date: 5 April 2018

Organic mononitrites of 1,2-propanediol act as an effective NO-releasing vasodilator in pulmonary hypertension and exhibit no cross-tolerance with nitroglycerin in anesthetized pigs

Nilsson KF, Goździk W, Frostell C, Zieliński S, Zielińska M, Ratajczak K, Skrzypczak P, Rodziewicz S, Albert J, Gustafsson LE

Drug Design, Development and Therapy 2018, 12:685-694

Published Date: 29 March 2018

The role of propranolol as a radiosensitizer in gastric cancer treatment

Liao XH, Chaudhary P, Qiu G, Che XM, Fan L

Drug Design, Development and Therapy 2018, 12:639-645

Published Date: 28 March 2018

Benralizumab in the treatment of severe asthma: design, development and potential place in therapy

Pelaia C, Vatrella A, Bruni A, Terracciano R, Pelaia G

Drug Design, Development and Therapy 2018, 12:619-628

Published Date: 21 March 2018

Rucaparib: a novel PARP inhibitor for BRCA advanced ovarian cancer

Colombo I, Lheureux S, Oza AM

Drug Design, Development and Therapy 2018, 12:605-617

Published Date: 21 March 2018

Tendinopathy: injury, repair, and current exploration

Lipman K, Wang CC, Ting K, Soo C, Zheng Z

Drug Design, Development and Therapy 2018, 12:591-603

Published Date: 20 March 2018

The hydroxypropyl–β-cyclodextrin complexation of toltrazuril for enhancing bioavailability

Zhang L, Liu MX, Lu CC, Ren DD, Fan GQ, Liu C, Liu MJ, Shu G, Peng GN, Yuan ZX, Zhong ZJ, Zhang W, Fu HL

Drug Design, Development and Therapy 2018, 12:583-589

Published Date: 19 March 2018

Bioequivalence of a biosimilar enoxaparin sodium to Clexane® after single 100 mg subcutaneous dose: results of a randomized, double-blind, crossover study in healthy volunteers

Martínez González J, Monreal M, Ayani Almagia I, Llaudó Garín J, Ochoa Díaz de Monasterioguren L, Gutierro Adúriz I

Drug Design, Development and Therapy 2018, 12:575-582

Published Date: 19 March 2018

Pharmacokinetic and bioequivalence study of a telmisartan/S-amlodipine fixed-dose combination (CKD-828) formulation and coadministered telmisartan and S-amlodipine in healthy subjects

Kang WY, Seong SJ, Ohk B, Gwon M, Kim BK, La S, Kim HJ, Cho S, Yoon Y, Yang DH, Lee HW

Drug Design, Development and Therapy 2018, 12:545-553

Published Date: 14 March 2018

Involvement of NF-κB and HSP70 signaling pathways in the apoptosis of MDA-MB-231 cells induced by a prenylated xanthone compound, α-mangostin, from Cratoxylum arborescens [Corrigendum] [Retraction]

Ibrahim MY, Mohd Hashim N, Mohan S, Mohd Ali H, Abdelwahab S, Kamalidehghan B, Ghaderian M, Dehghan F, Salim LZ, Karimian H, Yahayu M, Ee Cheng Lian G, Abdulla M, Farjam AS

Drug Design, Development and Therapy 2018, 12:533-534

Published Date: 13 March 2018

Can dexmedetomidine reduce atrial fibrillation after cardiac surgery? A systematic review and meta-analysis

Zhu ZP, Zhou HM, Ni YJ, Wu C, Zhang CJ, Ling XY

Drug Design, Development and Therapy 2018, 12:521-531

Published Date: 12 March 2018

Inhibitory effect of celecoxib on agomelatine metabolism in vitro and in vivo

He JY, Fang P, Zheng X, Wang CC, Liu TH, Zhang BW, Wen J, Xu RA

Drug Design, Development and Therapy 2018, 12:513-519

Published Date: 9 March 2018

Development of small bisquaternary cholinesterase inhibitors as drugs for pre-treatment of nerve agent poisonings

Kuca K, Karasova JZ, Soukup O, Kassa J, Novotna E, Sepsova V, Horova A, Pejchal J, Hrabinova M, Vodakova E, Jun D, Nepovimova E, Valis M, Musilek K

Drug Design, Development and Therapy 2018, 12:505-512

Published Date: 9 March 2018

Synovial tissue quantitative proteomics analysis reveals paeoniflorin decreases LIFR and ASPN proteins in experimental rheumatoid arthritis

Yang S, Xing ZH, Liu T, Zhou J, Liang QH, Tang T, Cui HJ, Peng WJ, Xiong XG, Wang Y

Drug Design, Development and Therapy 2018, 12:463-473

Published Date: 6 March 2018

Intra-articular platelet-rich plasma versus hyaluronic acid in the treatment of knee osteoarthritis: a meta-analysis

Zhang HF, Wang CG, Li H, Huang YT, Li ZJ

Drug Design, Development and Therapy 2018, 12:445-453

Published Date: 5 March 2018

Efficacy of atorvastatin on the prevention of contrast-induced acute kidney injury: a meta-analysis

Liu L, Liu Y, Wu M, Sun Y, Ma F

Drug Design, Development and Therapy 2018, 12:437-444

Published Date: 2 March 2018

Risk factors for calcineurin inhibitor nephrotoxicity after renal transplantation: a systematic review and meta-analysis

Xia T, Zhu S, Wen Y, Gao S, Li M, Tao X, Zhang F, Chen W

Drug Design, Development and Therapy 2018, 12:417-428

Published Date: 28 February 2018

Magnesium: does it reduce ischemia/reperfusion injury in an adnexal torsion rat model?

Celik Kavak E, Gulcu Bulmus F, Bulmus O, Kavak SB, Kocaman N

Drug Design, Development and Therapy 2018, 12:409-415

Published Date: 28 February 2018

Fasudil inhibits proliferation and migration of Hep-2 laryngeal carcinoma cells

Zhang X, Wu N

Drug Design, Development and Therapy 2018, 12:373-381

Published Date: 23 February 2018

Therapeutic potential of bimatoprost for the treatment of eyebrow hypotrichosis

Chanasumon N, Sriphojanart T, Suchonwanit P

Drug Design, Development and Therapy 2018, 12:365-372

Published Date: 22 February 2018

Formulation design and development of matrix diffusion controlled transdermal drug delivery of glimepiride

Akram MR, Ahmad M, Abrar A, Sarfraz RM, Mahmood A

Drug Design, Development and Therapy 2018, 12:349-364

Published Date: 21 February 2018

Short-term efficacy of intravitreal conbercept in treatment-naive patients with polypoidal choroidal vasculopathy

Peng Y, Zhang X, Li M, Liu B, Mi L, Zuo C, Wen F

Drug Design, Development and Therapy 2018, 12:339-345

Published Date: 19 February 2018

Pharmacokinetics and tolerability of eletriptan hydrobromide in healthy Korean subjects

Kim YK, Shin KH, Alderman J, Yu KS, Jang IJ, Lee S

Drug Design, Development and Therapy 2018, 12:331-337

Published Date: 19 February 2018

Berberine nanoparticles with enhanced in vitro bioavailability: characterization and antimicrobial activity

Sahibzada MUK, Sadiq A, Faidah HS, Khurram M, Amin MU, Haseeb A, Kakar M

Drug Design, Development and Therapy 2018, 12:303-312

Published Date: 14 February 2018

Comparison of the long-term efficacy and safety of generic tacrolimus, Tacrobell, with Prograf in liver transplant recipients

Choi HJ, Kim DG, Kwak BJ, Han JH, Hong TH, You YK

Drug Design, Development and Therapy 2018, 12:295-301

Published Date: 13 February 2018

Asthma and poly(ADP-ribose) polymerase inhibition: a new therapeutic approach

Zaffini R, Gotte G, Menegazzi M

Drug Design, Development and Therapy 2018, 12:281-293

Published Date: 12 February 2018

Reference ranges for antiepileptic drugs revisited: a practical approach to establish national guidelines

Reimers A, Berg JA, Burns ML, Brodtkorb E, Johannessen SI, Johannessen Landmark C

Drug Design, Development and Therapy 2018, 12:271-280

Published Date: 8 February 2018

Experimental and molecular modeling approach to optimize suitable polymers for fabrication of stable fluticasone nanoparticles with enhanced dissolution and antimicrobial activity

Ahmed S, Govender T, Khan I, ur Rehman N, Ali W, Shah SMH, Khan S, Hussain Z, Ullah R, Alsaid MS

Drug Design, Development and Therapy 2018, 12:255-269

Published Date: 5 February 2018

Dysregulation of Neuregulin-1/ErbB signaling in the hippocampus of rats after administration of doxorubicin

Liao D, Guo Y, Xiang D, Dang R, Xu P, Cai H, Cao L, Jiang P

Drug Design, Development and Therapy 2018, 12:231-239

Published Date: 30 January 2018

Durvalumab: an investigational anti-PD-L1 monoclonal antibody for the treatment of urothelial carcinoma

Faiena I, Cummings AL, Crosetti AM, Pantuck AJ, Chamie K, Drakaki A

Drug Design, Development and Therapy 2018, 12:209-215

Published Date: 23 January 2018

Bispecific antibodies: design, therapy, perspectives

Sedykh SE, Prinz VV, Buneva VN, Nevinsky GA

Drug Design, Development and Therapy 2018, 12:195-208

Published Date: 22 January 2018

Anticonvulsant and reproductive toxicological studies of the imidazole-based histamine H3R antagonist 2-18 in mice

Bastaki SM, Abdulrazzaq YM, Shafiullah M, Więcek M, Kieć-Kononowicz K, Sadek B

Drug Design, Development and Therapy 2018, 12:179-194

Published Date: 19 January 2018

Involvement of microRNA-146a in diabetic peripheral neuropathy through the regulation of inflammation

Feng Y, Chen L, Luo Q, Wu M, Chen Y, Shi X

Drug Design, Development and Therapy 2018, 12:171-177

Published Date: 17 January 2018

Efficacy and side effects of intravenous theophylline in acute asthma: a systematic review and meta-analysis

Mahemuti G, Zhang H, Li J, Tieliwaerdi N, Ren L

Drug Design, Development and Therapy 2018, 12:99-120

Published Date: 10 January 2018

Peptides derived from Plasmodium falciparum leucine-rich repeat 1 bind to serine/threonine phosphatase type 1 and inhibit parasite growth in vitro

Pierrot C, Zhang X, Zanghi G, Fréville A, Rebollo A, Khalife J

Drug Design, Development and Therapy 2018, 12:85-88

Published Date: 9 January 2018

Quantitative assessment of the effects of chitosan intervention on blood pressure control

Huang H, Zou Y, Chi H

Drug Design, Development and Therapy 2018, 12:67-75

Published Date: 28 December 2017

The oral bioavailability, excretion and cytochrome P450 inhibition properties of epiberberine: an in vivo and in vitro evaluation

Chen N, Yang X, Guo C, Bi X, Chen J, Chen H, Li H, Lin H, Zhang Y

Drug Design, Development and Therapy 2018, 12:57-65

Published Date: 28 December 2017

Portulaca oleracea L. alleviates liver injury in streptozotocin-induced diabetic mice

Zheng G, Mo F, Ling C, Peng H, Gu W, Li M, Chen Z

Drug Design, Development and Therapy 2018, 12:47-55

Published Date: 28 December 2017

Clinical features of hypophosphatemic osteomalacia induced by long-term low-dose adefovir dipivoxil

Zhu S, Yang YH, Gao RW, Li R, Zou YZ, Feng L, Zhang B

Drug Design, Development and Therapy 2018, 12:41-45

Published Date: 27 December 2017

Leishmaniasis in humans: drug or vaccine therapy?

Ghorbani M, Farhoudi R

Drug Design, Development and Therapy 2018, 12:25-40

Published Date: 22 December 2017

Intra-articular collagenase injection increases range of motion in a rat knee flexion contracture model

Wong K, Trudel G, Laneuville O

Drug Design, Development and Therapy 2018, 12:15-24

Published Date: 21 December 2017

HX575: established biosimilarity in the treatment of renal anemia and 10 years of clinical experience

Dellanna F, Goldsmith D, Krendyukov A, Seidl A, Höbel N, Combe C

Drug Design, Development and Therapy 2018, 12:9-14

Published Date: 18 December 2017