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Drug Design, Development and Therapy


Archive: Volume 13, 2019

Monosialoganglioside protects against bupivacaine-induced neurotoxicity caused by endoplasmic reticulum stress in rats

Liu B, Ji J, Feng Q, Luo X, Yan X, Ni Y, He Y, Mao Z, Liu J

Drug Design, Development and Therapy 2019, 13:707-718

Published Date: 19 February 2019

Dexmedetomidine attenuates the neurotoxicity of propofol toward primary hippocampal neurons in vitro via Erk1/2/CREB/BDNF signaling pathways

Tu Y, Liang Y, Xiao Y, Lv J, Guan R, Xiao F, Xie Y, Xiao Q

Drug Design, Development and Therapy 2019, 13:695-706

Published Date: 19 February 2019

Synthesis of budesonide conjugates and their anti-inflammatory effects: a preliminary study

Yan Y, Wang P, Li R, Sun Y, Zhang R, Huo C, Xing J, Dong Y

Drug Design, Development and Therapy 2019, 13:681-694

Published Date: 19 February 2019

Update in treatment of uveitic macular edema

Koronis S, Stavrakas P, Balidis M, Kozeis N, Tranos PG

Drug Design, Development and Therapy 2019, 13:667-680

Published Date: 19 February 2019

Ginkgo biloba extract-761 protects myocardium by regulating Akt/Nrf2 signal pathway

Chen X, Ren S, Dong J, Qiu C, Chen Y, Tao H

Drug Design, Development and Therapy 2019, 13:647-655

Published Date: 13 February 2019

Epigallocatechin-3-gallate in the prevention and treatment of hepatocellular carcinoma: experimental findings and translational perspectives

Bimonte S, Albino V, Piccirillo M, Nasto A, Molino C, Palaia R, Cascella M

Drug Design, Development and Therapy 2019, 13:611-621

Published Date: 12 February 2019

Emodin induces apoptosis and autophagy of fibroblasts obtained from patient with ankylosing spondylitis

Ma C, Wen B, Zhang Q, Shao P, Gu W, Qu K, Shi Y, Wang B

Drug Design, Development and Therapy 2019, 13:601-609

Published Date: 11 February 2019

The underlying mechanisms of Jie-Du-Hua-Yu granule for protecting rat liver failure

Qiu H, Mao D, Tang N, Long F, Zhang R, Wang M, Shi Q, Li J, Jiang Q, Chen Y, Wang X

Drug Design, Development and Therapy 2019, 13:589-600

Published Date: 11 February 2019

Cathepsin G cleaves and activates IL-36γ and promotes the inflammation of psoriasis

Guo J, Tu J, Hu YY, Song GX, Yin ZQ

Drug Design, Development and Therapy 2019, 13:581-588

Published Date: 8 February 2019

Efficacy of a recombinant single-chain fragment variable region, VasSF, as a new drug for vasculitis

Kameoka Y, Kishi F, Koura M, Yamakawa Y, Nagasawa R, Ito F, Matsuda J, Suzuki O, Nakayama T, Suzuki K

Drug Design, Development and Therapy 2019, 13:555-568

Published Date: 5 February 2019

The benefit of taxane-based therapies over fluoropyrimidine plus platinum (FP) in the treatment of esophageal cancer: a meta-analysis of clinical studies

Wang T, Yu J, Liu M, Chen Y, Zhu C, Lu L, Wang M, Min L, Liu X, Zhang X, Gubat JA, Chen Y

Drug Design, Development and Therapy 2019, 13:539-553

Published Date: 5 February 2019

Safety and efficacy of atezolizumab in the treatment of cancers: a systematic review and pooled-analysis

Tie Y, Yang H, Zhao R, Zheng H, Yang D, Zhao J, Liu M

Drug Design, Development and Therapy 2019, 13:523-538

Published Date: 4 February 2019

Bisperoxovanadium protects against spinal cord injury by regulating autophagy via activation of ERK1/2 signaling

Tang Y, Li K, Yang C, Huang K, Zhou J, Shi Y, Xie K, Liu J

Drug Design, Development and Therapy 2019, 13:513-521

Published Date: 1 February 2019

A nucleoside-sparing regimen of dolutegravir plus ritonavir-boosted atazanavir in HIV-1-infected patients with virological failure: the DOLATAV study

Spagnuolo V, Galli L, Poli A, Bigoloni A, Fumagalli L, Gianotti N, Nozza S, Ferrari D, Locatelli M, Lazzarin A, Castagna A

Drug Design, Development and Therapy 2019, 13:477-479

Published Date: 24 January 2019

Qingxin kaiqiao fang ameliorates memory impairment and inhibits apoptosis in APP/PS1 double transgenic mice through the MAPK pathway

Gao SY, Lin J, Wang T, Shen Y, Li Y, Yang W, Zhou K, Hu H

Drug Design, Development and Therapy 2019, 13:459-475

Published Date: 23 January 2019

Structure–activity relationship of an antimicrobial peptide, Phylloseptin-PHa: balance of hydrophobicity and charge determines the selectivity of bioactivities

Liu Y, Du Q, Ma C, Xi X, Wang L, Zhou M, Burrows JF, Chen T, Wang H

Drug Design, Development and Therapy 2019, 13:447-458

Published Date: 23 January 2019

MicroRNA-339 inhibits human hepatocellular carcinoma proliferation and invasion via targeting ZNF689

Zeng H, Zheng J, Wen S, Luo J, Shao G, Zhang Y

Drug Design, Development and Therapy 2019, 13:435-445

Published Date: 22 January 2019

Design, synthesis, and biologic evaluation of novel chrysin derivatives as cytotoxic agents and caspase-3/7 activators

Al-Oudat BA, Alqudah MA, Audat SA, Al-Balas QA, El-Elimat T, Hassan MA, Frhat IN, Azaizeh MM

Drug Design, Development and Therapy 2019, 13:423-433

Published Date: 22 January 2019

A real-life experience of sorafenib treatment for patients with advanced hepatocellular carcinoma: a retrospective analysis at Cathay General Hospital, 2007–2015

Huang CC, Chen HY, Chang RH, Liao PA, Lien HH, Hung CS, Yang SS, Hu JT

Drug Design, Development and Therapy 2019, 13:397-404

Published Date: 22 January 2019

Screening of novel HSP-inducing compounds to conserve cardiomyocyte function in experimental atrial fibrillation

van Marion DMS, Hu X, Zhang D, Hoogstra-Berends F, Seerden JPG, Loen L, Heeres A, Steen H, Henning RH, Brundel BJJM

Drug Design, Development and Therapy 2019, 13:345-364

Published Date: 18 January 2019

YB-1 modulates the drug resistance of glioma cells by activation of MDM2/p53 pathway

Tong H, Zhao K, Zhang J, Zhu J, Xiao J

Drug Design, Development and Therapy 2019, 13:317-326

Published Date: 14 January 2019

A brief report of toxicity end points of HER2 vaccines for the treatment of patients with HER2+ breast cancer

Costa R, Zaman S, Sharpe S, Helenowski I, Shaw C, Han H, Soliman H, Czerniecki B

Drug Design, Development and Therapy 2019, 13:309-316

Published Date: 14 January 2019

Antistaphylococcal evaluation of indole–naphthalene hybrid analogs

Ashraf K, Yasrebi K, Adeniyi ET, Hertlein T, Ohlsen K, Lalk M, Erdmann F, Hilgeroth A

Drug Design, Development and Therapy 2019, 13:275-283

Published Date: 10 January 2019

Catalpol prevents denervated muscular atrophy related to the inhibition of autophagy and reduces BAX/BCL2 ratio via mTOR pathway

Wang Y, Shao YL, Gao YQ, Wan GR, Wan D, Zhu HF, Qiu Y, Ye XY

Drug Design, Development and Therapy 2019, 13:243-253

Published Date: 31 December 2018

A colon-specific prodrug of metoclopramide ameliorates colitis in an experimental rat model

Yang Y, Kim W, Kim D, Jeong S, Yoo JW, Jung Y

Drug Design, Development and Therapy 2019, 13:231-242

Published Date: 28 December 2018

Xyloketal derivative C53N protects against mild traumatic brain injury in mice

Liang F, Su F, Wang X, Long S, Zheng Y, He X, Pang J, Pei Z

Drug Design, Development and Therapy 2019, 13:173-182

Published Date: 27 December 2018

Urapidil, compared to nitroglycerin, has better clinical safety in the treatment of hypertensive patients with acute heart failure: a meta-analysis

Shi J, Li Y, Xing C, Peng P, Shi H, Ding H, Zheng P, Ning G, Feng S

Drug Design, Development and Therapy 2019, 13:161-172

Published Date: 27 December 2018

Fenofibrate modified-release pellets with lag phase and high oral bioavailability

Li F, Zheng X, Bao YC, Chen T, Zeng J, Xu XL, Yan C, Feng LL

Drug Design, Development and Therapy 2019, 13:141-151

Published Date: 24 December 2018

Tetrandrine suppresses cervical cancer growth by inducing apoptosis in vitro and in vivo

Zhang H, Xie B, Zhang Z, Sheng X, Zhang S

Drug Design, Development and Therapy 2019, 13:119-127

Published Date: 20 December 2018

Tocilizumab in the treatment of rheumatoid arthritis: an evidence-based review and patient selection

Biggioggero M, Crotti C, Becciolini A, Favalli EG

Drug Design, Development and Therapy 2019, 13:57-70

Published Date: 19 December 2018

Ocular side effects of levitra® (vardenafil) – results of a double-blind crossover study in healthy male subjects

Roessler G, Vobig M, Walter P, Mazinani BAE

Drug Design, Development and Therapy 2019, 13:37-43

Published Date: 18 December 2018

Multimetal organic frameworks as drug carriers: aceclofenac as a drug candidate

Al Haydar M, Abid HR, Sunderland B, Wang S

Drug Design, Development and Therapy 2019, 13:23-35

Published Date: 18 December 2018

Cytoprotective effects of molsidomine against methotrexate-induced hepatotoxicity: an experimental rat study

Samdanci ET, Huz M, Ozhan O, Tanbek K, Pamukcu E, Akatli AN, Parlakpinar H

Drug Design, Development and Therapy 2019, 13:13-21

Published Date: 20 December 2018