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Drug Design, Development and Therapy


Archive: Volume 13, 2019

Synthesis and antihepatotoxic activity of dihydropyrimidinone derivatives linked with 1,4-benzodioxane

Bhat MA, Al-Omar MA, Khan AA, Alanazi AM, Naglah AM

Drug Design, Development and Therapy 2019, 13:2393-2404

Published Date: 18 July 2019

A new approach of ocular nebulization with vitamin B12 versus oxytocin for the treatment of dry eye disease: an in vivo confocal microscopy study

Yang J, Liu Y, Xu Y, Li X, Fu J, Jiang X, Chou Y, Ma J, Hao R, Zhang R, Qiu W, Li X

Drug Design, Development and Therapy 2019, 13:2381-2391

Published Date: 18 July 2019

MicroRNA-664 suppresses the growth of cervical cancer cells via targeting c-Kit

Lv M, Ou R, Zhang Q, Lin F, Li X, Wang K, Xu Y

Drug Design, Development and Therapy 2019, 13:2371-2379

Published Date: 17 July 2019

Plumbagin promotes human hepatoma SMMC-7721 cell apoptosis via caspase-3/vimentin signal-mediated EMT

Wei Y, Lv B, Xie J, Zhang Y, Lin Y, Wang S, Zhong J, Chen Y, Peng Y, Ma J

Drug Design, Development and Therapy 2019, 13:2343-2355

Published Date: 15 July 2019

Lycopene protects against myocardial ischemia-reperfusion injury by inhibiting mitochondrial permeability transition pore opening

Li X, Jia P, Huang Z, Liu S, Miao J, Guo Y, Wu N, Jia D

Drug Design, Development and Therapy 2019, 13:2331-2342

Published Date: 11 July 2019

Differences in tolerability of pirfenidone between elderly and younger patients with idiopathic pulmonary fibrosis

Sakayori M, Terada J, Abe M, Hirasawa Y, Suzuki K, Yoshioka K, Tsushima K, Tatsumi K

Drug Design, Development and Therapy 2019, 13:2295-2303

Published Date: 11 July 2019

Durability of INI-containing regimens after switching from PI-containing regimens: a single-centre cohort of drug-experienced HIV-infected subjects

Giacomelli A, Ranzani A, Oreni L, Gervasi E, Lupo A, Ridolfo AL, Galli M, Rusconi S

Drug Design, Development and Therapy 2019, 13:2271-2282

Published Date: 9 July 2019

The protective effect and mechanism of the FXR agonist obeticholic acid via targeting gut microbiota in non-alcoholic fatty liver disease

Zhang DY, Zhu L, Liu HN, Tseng YJ, Weng SQ, Liu TT, Dong L, Shen XZ

Drug Design, Development and Therapy 2019, 13:2249-2270

Published Date: 5 July 2019

Jatrorrhizine inhibits colorectal carcinoma proliferation and metastasis through Wnt/β-catenin signaling pathway and epithelial–mesenchymal transition

Wang P, Gao XY, Yang SQ, Sun ZX, Dian LL, Qasim M, Phyo AT, Liang ZS, Sun YF

Drug Design, Development and Therapy 2019, 13:2235-2247

Published Date: 8 July 2019

Delivery of folic acid-modified liposomal curcumin for targeted cervical carcinoma therapy

Wang WY, Cao YX, Zhou X, Wei B

Drug Design, Development and Therapy 2019, 13:2205-2213

Published Date: 4 July 2019

Activation of the P38/CREB/MMP13 axis is associated with osteoarthritis

Ji B, Ma Y, Wang H, Fang X, Shi P

Drug Design, Development and Therapy 2019, 13:2195-2204

Published Date: 3 July 2019

Tablet or capsule form of generic mycophenolate mofetil (My-Rept®) after liver transplantation: a prospective randomized trial

Kim JM, Oh JW, Kim S, Rhu J, Lee JS, Kim KS, Choi GS, Joh JW

Drug Design, Development and Therapy 2019, 13:2187-2193

Published Date: 2 July 2019

Evaluation of novel pyrimidine derivatives as a new class of mushroom tyrosinase inhibitor

Mirmortazavi SS, Farvandi M, Ghafouri H, Mohammadi A, Shourian M

Drug Design, Development and Therapy 2019, 13:2169-2178

Published Date: 8 July 2019

Preemptive analgesia after lumbar spine surgery by pregabalin and celecoxib: a prospective study

Kien NT, Geiger P, Van Chuong H, Cuong NM, Van Dinh N, Pho DC, Anh VT, Giang NT

Drug Design, Development and Therapy 2019, 13:2145-2152

Published Date: 3 July 2019

Role of GRP78 inhibiting artesunate-induced ferroptosis in KRAS mutant pancreatic cancer cells

Wang K, Zhang Z, Wang M, Cao X, Qi J, Wang D, Gong A, Zhu H

Drug Design, Development and Therapy 2019, 13:2135-2144

Published Date: 2 July 2019

Ginsenoside Rb1 pretreatment reverses hippocampal changes in BDNF/TrkB mRNA and protein in rats subjected to acute immobilization stress

Kang X, Hong W, Xie K, Tang H, Tang J, Luo S, Geng W, Jia D

Drug Design, Development and Therapy 2019, 13:2127-2134

Published Date: 1 July 2019

Phosphocreatine attenuates Gynura segetum-induced hepatocyte apoptosis via a SIRT3-SOD2-mitochondrial reactive oxygen species pathway

Li DP, Chen YL, Jiang HY, Chen Y, Zeng XQ, Xu LL, Ye Y, Ke CQ, Lin G, Wang JY, Gao H

Drug Design, Development and Therapy 2019, 13:2081-2096

Published Date: 27 June 2019

Dexmedetomidine protects PC12 cells from lidocaine-induced cytotoxicity via downregulation of Stathmin 1

Tan Y, Bi X, Wang Q, Li Y, Zhang N, Lao J, Liu X

Drug Design, Development and Therapy 2019, 13:2067-2079

Published Date: 3 July 2019

Ginsenoside Rg3 protects mouse leydig cells against triptolide by downregulation of miR-26a

Liang H, Zhang S, Li Z

Drug Design, Development and Therapy 2019, 13:2057-2066

Published Date: 24 June 2019

A novel mutation panel for predicting etoposide resistance in small-cell lung cancer

Qiu Z, Lin A, Li K, Lin W, Wang Q, Wei T, Zhu W, Luo P, Zhang J

Drug Design, Development and Therapy 2019, 13:2021-2041

Published Date: 21 June 2019

TMF inhibits miR-29a/Wnt/β-catenin signaling through upregulating Foxo3a activity in osteoarthritis chondrocytes

Huang X, Chen Z, Shi W, Zhang R, Li L, Liu H, Wu L

Drug Design, Development and Therapy 2019, 13:2009-2019

Published Date: 19 June 2019

Evaluating guselkumab: an anti-IL-23 antibody for the treatment of plaque psoriasis

Yang EJ, Smith MP, Ly K, Bhutani T

Drug Design, Development and Therapy 2019, 13:1993-2000

Published Date: 18 June 2019

Efficacy and safety of total glucosides of paeony combined with methotrexate and leflunomide for active rheumatoid arthritis: a meta-analysis

Huang Y, Wang H, Chen Z, Wang Y, Qin K, Huang Y, Ba X, Lin W, Tu S

Drug Design, Development and Therapy 2019, 13:1969-1984

Published Date: 17 June 2019

The neuroprotective effect of bisperoxovandium (pyridin-2-squaramide) in intracerebral hemorrhage

Liao XY, Lei Y, Chen SF, Cheng J, Zhao D, Zhang ZF, Han X, Zhang Y, Liao HB, Zhuang Y, Chen J, Zhou HB, Wan Q, Zou YY

Drug Design, Development and Therapy 2019, 13:1957-1967

Published Date: 13 June 2019

Solutol®HS15+pluronicF127 and Solutol®HS15+pluronicL61 mixed micelle systems for oral delivery of genistein

Ding P, Chen Y, Cao G, Shen H, Ju J, Li W

Drug Design, Development and Therapy 2019, 13:1947-1956

Published Date: 7 June 2019

Notopterol-induced apoptosis and differentiation in human acute myeloid leukemia HL-60 cells

Huang Q, Wang L, Ran Q, Wang J, Wang C, He H, Li L, Qi H

Drug Design, Development and Therapy 2019, 13:1927-1940

Published Date: 6 June 2019

Decreased sEng plasma levels in hypertensive patients with endothelial dysfunction under chronic treatment with Perindopril

Buda V, Andor M, Baibata DE, Cozlac R, Radu G, Coricovac D, Danciu C, Ledeti I, Cheveresan A, Nica C, Tuduce P, Tomescu MC

Drug Design, Development and Therapy 2019, 13:1915-1925

Published Date: 4 June 2019

Effects of Qi Teng Xiao Zhuo granules on circRNA expression profiles in rats with chronic glomerulonephritis

Gao JR, Jiang NN, Jiang H, Wei LB, Gao YC, Qin XJ, Zhu MQ, Wang J

Drug Design, Development and Therapy 2019, 13:1901-1913

Published Date: 4 June 2019

Efficacy and toxicity of cladribine for the treatment of refractory acute myeloid leukemia: a meta-analysis

Zhou A, Han Q, Song H, Zi J, Ma J, Ge Z

Drug Design, Development and Therapy 2019, 13:1867-1878

Published Date: 29 May 2019

Therapeutic potential of pravastatin for random skin flaps necrosis: involvement of promoting angiogenesis and inhibiting apoptosis and oxidative stress [Corrigendum]

Lin J, Jia C, Wang Y, Jiang S, Jia Z, Chen N, Sheng S, Li S, Jiang L, Xu H, Zhou K, Chen Y

Drug Design, Development and Therapy 2019, 13:1865-1866

Published Date: 29 May 2019

Use of lidocaine to prevent postoperative coughing after partial laryngectomy: comparison of three delivery methods

Wang Y, Lu WS, Qiao H, Zhao J, Fan Q

Drug Design, Development and Therapy 2019, 13:1835-1841

Published Date: 27 May 2019

A novel non-invasive monitoring assay of 5-azacitidine efficacy using global DNA methylation of peripheral blood in myelodysplastic syndrome

Asano M, Ohyashiki JH, Kobayashi-Kawana C, Umezu T, Imanishi S, Azuma K, Akahane D, Fujimoto H, Ito Y, Ohyashiki K

Drug Design, Development and Therapy 2019, 13:1821-1833

Published Date: 30 May 2019

Ferulic acid attenuates liver fibrosis and hepatic stellate cell activation via inhibition of TGF-β/Smad signaling pathway [Corrigendum]

Mu M, Zuo S, Wu RM, Deng KS, Lu S, Zhu JJ, Zou GL, Yang J, Cheng ML, Zhao XK

Drug Design, Development and Therapy 2019, 13:1819-1820

Published Date: 24 May 2019

Frequency, clinical features and differential response to therapy of concurrent ALK/EGFR alterations in Chinese lung cancer patients

Liu J, Mu Z, Liu L, Li K, Jiang R, Chen P, Zhou Q, Jin M, Ma Y, Xie Y, Xiang J, Li B, Ma Y, Mao X, Zhang L, Zhang T, Wu D

Drug Design, Development and Therapy 2019, 13:1809-1817

Published Date: 23 May 2019

Effect of dexmedetomidine on etomidate-induced myoclonus: a randomized, double-blind controlled trial

Miao S, Zou L, Wang G, Wang X, Liu S, Shi M

Drug Design, Development and Therapy 2019, 13:1803-1808

Published Date: 27 May 2019

Low-dose doxycycline inhibits hydrogen peroxide-induced oxidative stress, MMP-2 up-regulation and contractile dysfunction in human saphenous vein grafts

Saeed M, Arun MZ, Guzeloglu M, Onursal C, Gokce G, Korkmaz CG, Reel B

Drug Design, Development and Therapy 2019, 13:1791-1801

Published Date: 23 May 2019

Synthesis, comparative docking, and pharmacological activity of naproxen amino acid derivatives as possible anti-inflammatory and analgesic agents

Elhenawy AA, Al-Harbi LM, Moustafa GO, El-Gazzar MA, Abdel-Rahman RF, Salim AE

Drug Design, Development and Therapy 2019, 13:1773-1790

Published Date: 24 May 2019

SU5416 attenuated lipopolysaccharide-induced acute lung injury in mice by modulating properties of vascular endothelial cells

Huang X, Zhu J, Jiang Y, Xu C, Lv Q, Yu D, Shi K, Ruan Z, Wang Y

Drug Design, Development and Therapy 2019, 13:1763-1772

Published Date: 23 May 2019

Population pharmacokinetic analysis of tramadol and O-desmethyltramadol with genetic polymorphism of CYP2D6

Lee J, Yoo H, Bae JW, Lee S, Shin K

Drug Design, Development and Therapy 2019, 13:1751-1761

Published Date: 23 May 2019

The effect of midazolam administration for the prevention of emergence agitation in pediatric patients with extreme fear and non-cooperation undergoing dental treatment under sevoflurane anesthesia, a double-blind, randomized study

Kawai M, Kurata S, Sanuki T, Mishima G, Kiriishi K, Watanabe T, Ozaki-Honda Y, Yoshida M, Okayasu I, Ayuse T, Tanoue N, Ayuse T

Drug Design, Development and Therapy 2019, 13:1729-1737

Published Date: 17 May 2019

Genetic variations in the transcription factors GATA4 and GATA6 and bleeding complications in patients receiving warfarin therapy

Yee J, Kim W, Chang BC, Chung JE, Lee KE, Gwak HS

Drug Design, Development and Therapy 2019, 13:1717-1727

Published Date: 17 May 2019

Sevoflurane post-conditioning alleviates neonatal rat hypoxic-ischemic cerebral injury via Ezh2-regulated autophagy

Xue H, Xu Y, Wang S, Wu ZY, Li XY, Zhang YH, Niu JY, Gao QS, Zhao P

Drug Design, Development and Therapy 2019, 13:1691-1706

Published Date: 15 May 2019

Efficacy of a recombinant single-chain fragment variable region, VasSF, as a new drug for vasculitis [Corrigendum]

Kameoka Y, Kishi F, Koura M, Yamakawa Y, Nagasawa R, Ito F, Matsuda J, Suzuki O, Nakayama T, Suzuki K

Drug Design, Development and Therapy 2019, 13:1689-1690

Published Date: 22 May 2019

Cardiovascular adverse events during treatment with darunavir-based regimens in an Italian observational study

Antinori A, Rusconi S, Gianotti N, Bini T, Mancusi D, Termini R

Drug Design, Development and Therapy 2019, 13:1667-1685

Published Date: 14 May 2019

Dexibuprofen amide derivatives as potential anticancer agents: synthesis, in silico docking, bioevaluation, and molecular dynamic simulation

Ashraf Z, Mahmood T, Hassan M, Afzal S, Rafique H, Afzal K, Latip J

Drug Design, Development and Therapy 2019, 13:1643-1657

Published Date: 14 May 2019

Pharmacokinetics of fixed-dose combination of atorvastatin and metformin compared with individual tablets

Ghim JL, Phuong NTT, Kim MJ, Kim EJ, Song GS, Ahn S, Shin JG, Kim EY

Drug Design, Development and Therapy 2019, 13:1623-1632

Published Date: 13 May 2019

Formulation and evaluation of simvastatin polymeric nanoparticles loaded in hydrogel for optimum wound healing purpose

Farghaly Aly U, Abou-Taleb HA, Abdellatif AH, Sameh Tolba N

Drug Design, Development and Therapy 2019, 13:1567-1580

Published Date: 10 May 2019

In silico and in vitro studies of lupeol and iso-orientin as potential antidiabetic agents in a rat model

Malik A, Jamil U, Butt TT, Waquar S, Gan SH, Shafique H, Jafar TH

Drug Design, Development and Therapy 2019, 13:1501-1513

Published Date: 6 May 2019

Resveratrol reduces liver endoplasmic reticulum stress and improves insulin sensitivity in vivo and in vitro

Zhao H, Zhang Y, Shu L, Song G, Ma H

Drug Design, Development and Therapy 2019, 13:1473-1485

Published Date: 2 May 2019

Therapeutic potential of pravastatin for random skin flaps necrosis: involvement of promoting angiogenesis and inhibiting apoptosis and oxidative stress

Lin J, Jia C, Wang Y, Jiang S, Jia Z, Chen N, Sheng S, Li S, Jiang L, Xu H, Zhou K, Chen Y

Drug Design, Development and Therapy 2019, 13:1461-1472

Published Date: 1 May 2019

Synthesis of a vanadyl (IV) folate complex for the treatment of diabetes: spectroscopic, structural, and biological characterization

Naglah AM, Refat MS, Al-Omar MA, Bhat MA, AlKahtani HM, Al-Wasidi AS

Drug Design, Development and Therapy 2019, 13:1409-1420

Published Date: 30 April 2019

The TwistDock workflow for evaluation of bivalent Smac mimetics targeting XIAP

Huang Q, Peng Y, Peng Y, Wei D, Wei Y, Feng S

Drug Design, Development and Therapy 2019, 13:1373-1388

Published Date: 26 April 2019

Codelivery of GRP78 siRNA and docetaxel via RGD-PEG-DSPE/DOPA/CaP nanoparticles for the treatment of castration-resistant prostate cancer

Zhang X, He Z, Xiang L, Li L, Zhang H, Lin F, Cao H

Drug Design, Development and Therapy 2019, 13:1357-1372

Published Date: 29 April 2019

Clinical efficacy of 60-mg dexlansoprazole and 40-mg esomeprazole after 24 weeks for the on-demand treatment of gastroesophageal reflux disease grades A and B: a prospective randomized trial

Chiang HH, Wu DC, Hsu PI, Kuo CH, Tai WC, Yang SC, Wu KL, Yao CC, Tsai CE, Liang CM, Wang YK, Wang JW, Huang CF, Chuah SK

Drug Design, Development and Therapy 2019, 13:1347-1356

Published Date: 26 April 2019

Caffeic acid phenethyl ester suppressed growth and metastasis of nasopharyngeal carcinoma cells by inactivating the NF-κB pathway

Liang Y, Feng G, Wu L, Zhong S, Gao X, Tong Y, Cui W, Qin Y, Xu WQ, Xiao X, Zhang Z, Huang G, Zhou X

Drug Design, Development and Therapy 2019, 13:1335-1345

Published Date: 26 April 2019

Epigallocatechin-3-gallate enhances the osteoblastogenic differentiation of human adipose-derived stem cells

Zhang J, Wu K, Xu T, Wu J, Li P, Wang H, Wu H, Wu G

Drug Design, Development and Therapy 2019, 13:1311-1321

Published Date: 23 April 2019

Effects of dezocine for the prevention of postoperative catheter-related bladder discomfort: a prospective randomized trial

Zhang GF, Guo J, Qiu LL, Li SM, Zheng M, Xia JY, Yang JJ

Drug Design, Development and Therapy 2019, 13:1281-1288

Published Date: 23 April 2019

Pharmacokinetics and pharmacodynamics of the novel Nrf2 activator omaveloxolone in primates

Reisman SA, Gahir SS, Lee CY, Proksch JW, Sakamoto M, Ward KW

Drug Design, Development and Therapy 2019, 13:1259-1270

Published Date: 17 April 2019

The molecular mechanisms of Aloin induce gastric cancer cells apoptosis by targeting High Mobility Group Box 1

Tao H, Tang T, Wang S, Wang Z, Ma Y, Cai T, Cheng X, Qi S, Zhang Y, Qi Z

Drug Design, Development and Therapy 2019, 13:1221-1231

Published Date: 17 April 2019

Effect of butorphanol on etomidate-induced myoclonus: a systematic review and meta-analysis

Hua J, Miao S, Shi M, Tu Q, Wang X, Liu S, Wang G, Gan J

Drug Design, Development and Therapy 2019, 13:1213-1220

Published Date: 16 April 2019

Beneficial effects of resveratrol and exercise training on cardiac and aortic function and structure in the 3xTg mouse model of Alzheimer’s disease

Esfandiarei M, Hoxha B, Talley NA, Anderson MR, Alkhouli MF, Squire MA, Eckman DM, Babu JR, Lopaschuk GD, Broderick TL

Drug Design, Development and Therapy 2019, 13:1197-1211

Published Date: 17 April 2019

Tetramethylpyrazine attenuated bupivacaine-induced neurotoxicity in SH-SY5Y cells through regulating apoptosis, autophagy and oxidative damage

Wang S, Xia B, Qiao Z, Duan L, Wang G, Meng W, Liu Z, Wang Y, Zhang M

Drug Design, Development and Therapy 2019, 13:1187-1196

Published Date: 17 April 2019

Effect of umbelliferone on adjuvant-induced arthritis in rats by MAPK/NF-κB pathway

Ouyang L, Dan Y, Shao Z, Yang S, Yang C, Liu G, Zhou W, Duan D

Drug Design, Development and Therapy 2019, 13:1163-1170

Published Date: 11 April 2019

Quizartinib (AC220): a promising option for acute myeloid leukemia

Zhou F, Ge Z, Chen B

Drug Design, Development and Therapy 2019, 13:1117-1125

Published Date: 8 April 2019

A novel hybrid compound LLP2A-alendronate accelerates open fracture healing in a rabbit model

Wang Z, Zhao Y, Zhang D, Qi B, Xiao W, Hu X, Yu A

Drug Design, Development and Therapy 2019, 13:1077-1086

Published Date: 5 April 2019

Systematic elucidation of the mechanism of geraniol via network pharmacology

Zhang YF, Huang Y, Ni YH, Xu ZM

Drug Design, Development and Therapy 2019, 13:1069-1075

Published Date: 4 April 2019

Transportan-derived cell-penetrating peptide delivers siRNA to inhibit replication of influenza virus in vivo

Zhang C, Ren W, Liu Q, Tan Z, Li J, Tong C

Drug Design, Development and Therapy 2019, 13:1059-1068

Published Date: 4 April 2019

Formulation and bioequivalence studies of choline alfoscerate tablet comparing with soft gelatin capsule in healthy male volunteers

Min MH, Park JH, Hur JH, Shin HC, Cho YJ, Kim DD

Drug Design, Development and Therapy 2019, 13:1049-1058

Published Date: 5 April 2019

Metabolism of remimazolam in primary human hepatocytes during continuous long-term infusion in a 3-D bioreactor system

Freyer N, Knöspel F, Damm G, Greuel S, Schneider C, Seehofer D, Stöhr T, Petersen KU, Zeilinger K

Drug Design, Development and Therapy 2019, 13:1033-1047

Published Date: 2 April 2019

Jinlong capsule inhibits migration and invasion in human glioblastoma cells via the modulation of mTOR/S6 signaling pathway

Shi J, Zhang W, He L, Kong F, Pan M, Guo J, Xu X, Guo J, Wang H, Wang Y

Drug Design, Development and Therapy 2019, 13:1023-1032

Published Date: 1 April 2019

Efficacy and safety of paricalcitol in patients undergoing hemodialysis: a meta-analysis

Liu Y, Liu LY, Jia Y, Wu MY, Sun YY, Ma FZ

Drug Design, Development and Therapy 2019, 13:999-1009

Published Date: 28 March 2019

Emodin alleviates myocardial ischemia/reperfusion injury by inhibiting gasdermin D-mediated pyroptosis in cardiomyocytes

Ye B, Chen X, Dai S, Han J, Liang X, Lin S, Cai X, Huang Z, Huang W

Drug Design, Development and Therapy 2019, 13:975-990

Published Date: 25 March 2019

Mechanistic research holds promise for bacterial vaccines and phage therapies for Pseudomonas aeruginosa

Hoggarth A, Weaver A, Pu Q, Huang T, Schettler J, Chen F, Yuan X, Wu M

Drug Design, Development and Therapy 2019, 13:909-924

Published Date: 20 March 2019

Protective role of quercetin against manganese-induced injury in the liver, kidney, and lung; and hematological parameters in acute and subchronic rat models [Retraction]

Bahar E, Lee GH, Bhattarai KR, Lee HY, Kim HK, Handigund M, Choi MK, Han SY, Chae HJ, Yoon H

Drug Design, Development and Therapy 2019, 13:907-908

Published Date: 18 March 2019

Drug-release system of microchannel transport used in minimally invasive surgery for hemostasis

Huang H, Liu H, Zhou H, Liang Z, Song D, Zhang Y, Huang W, Zhao X, Wu B, Ye G, Huang Y

Drug Design, Development and Therapy 2019, 13:881-896

Published Date: 12 March 2019

Efficacy and safety of tacrolimus in induction therapy of patients with lupus nephritis

Zhou TB, Lin SJ, Yang S, Lin WS

Drug Design, Development and Therapy 2019, 13:857-869

Published Date: 12 March 2019

Clinical efficacy and safety of rituximab in lupus nephritis

Zhong Z, Li H, Zhong H, Zhou T

Drug Design, Development and Therapy 2019, 13:845-856

Published Date: 11 March 2019

Single-use suvorexant for treating insomnia during overnight polysomnography in patients with suspected obstructive sleep apnea: a single-center experience

Matsumura T, Terada J, Yoshimura C, Koshikawa K, Kinoshita T, Yahaba M, Nagashima K, Sakao S, Tatsumi K

Drug Design, Development and Therapy 2019, 13:809-816

Published Date: 28 February 2019

Utility of nintedanib for severe idiopathic pulmonary fibrosis: a single-center retrospective study [Corrigendum]

Abe M, Tsushima K, Sakayori M, Suzuki K, Ikari J, Terada J, Tatsumi K

Drug Design, Development and Therapy 2019, 13:807-808

Published Date: 28 February 2019

Physicochemical characterization and phase I study of CMAB008, an infliximab biosimilar produced by a different expression system

An Q, Zheng Y, Zhao Y, Liu T, Guo H, Zhang D, Qian W, Wang H, Guo Y, Hou S, Li J

Drug Design, Development and Therapy 2019, 13:791-805

Published Date: 12 March 2019

Synthesis, structure elucidation, and antifungal potential of certain new benzodioxole–imidazole molecular hybrids bearing ester functionalities

Al-Wabli RI, Al-Ghamdi AR, Ghabbour HA, Al-Agamy MH, Attia MI

Drug Design, Development and Therapy 2019, 13:775-789

Published Date: 26 February 2019

Ginkgolide B ameliorates myocardial ischemia reperfusion injury in rats via inhibiting endoplasmic reticulum stress

Guo C, Zhang J, Zhang P, Si A, Zhang Z, Zhao L, Lv F, Zhao G

Drug Design, Development and Therapy 2019, 13:767-774

Published Date: 26 February 2019

Monosialoganglioside protects against bupivacaine-induced neurotoxicity caused by endoplasmic reticulum stress in rats

Liu B, Ji J, Feng Q, Luo X, Yan X, Ni Y, He Y, Mao Z, Liu J

Drug Design, Development and Therapy 2019, 13:707-718

Published Date: 19 February 2019

Dexmedetomidine attenuates the neurotoxicity of propofol toward primary hippocampal neurons in vitro via Erk1/2/CREB/BDNF signaling pathways

Tu Y, Liang Y, Xiao Y, Lv J, Guan R, Xiao F, Xie Y, Xiao Q

Drug Design, Development and Therapy 2019, 13:695-706

Published Date: 19 February 2019

Synthesis of budesonide conjugates and their anti-inflammatory effects: a preliminary study

Yan Y, Wang P, Li R, Sun Y, Zhang R, Huo C, Xing J, Dong Y

Drug Design, Development and Therapy 2019, 13:681-694

Published Date: 19 February 2019

Update in treatment of uveitic macular edema

Koronis S, Stavrakas P, Balidis M, Kozeis N, Tranos PG

Drug Design, Development and Therapy 2019, 13:667-680

Published Date: 19 February 2019

Ginkgo biloba extract-761 protects myocardium by regulating Akt/Nrf2 signal pathway

Chen X, Ren S, Dong J, Qiu C, Chen Y, Tao H

Drug Design, Development and Therapy 2019, 13:647-655

Published Date: 13 February 2019

Epigallocatechin-3-gallate in the prevention and treatment of hepatocellular carcinoma: experimental findings and translational perspectives

Bimonte S, Albino V, Piccirillo M, Nasto A, Molino C, Palaia R, Cascella M

Drug Design, Development and Therapy 2019, 13:611-621

Published Date: 12 February 2019

Emodin induces apoptosis and autophagy of fibroblasts obtained from patient with ankylosing spondylitis

Ma C, Wen B, Zhang Q, Shao P, Gu W, Qu K, Shi Y, Wang B

Drug Design, Development and Therapy 2019, 13:601-609

Published Date: 11 February 2019

The underlying mechanisms of Jie-Du-Hua-Yu granule for protecting rat liver failure

Qiu H, Mao D, Tang N, Long F, Zhang R, Wang M, Shi Q, Li J, Jiang Q, Chen Y, Wang X

Drug Design, Development and Therapy 2019, 13:589-600

Published Date: 11 February 2019

Cathepsin G cleaves and activates IL-36γ and promotes the inflammation of psoriasis

Guo J, Tu J, Hu YY, Song GX, Yin ZQ

Drug Design, Development and Therapy 2019, 13:581-588

Published Date: 8 February 2019

Efficacy of a recombinant single-chain fragment variable region, VasSF, as a new drug for vasculitis

Kameoka Y, Kishi F, Koura M, Yamakawa Y, Nagasawa R, Ito F, Matsuda J, Suzuki O, Nakayama T, Suzuki K

Drug Design, Development and Therapy 2019, 13:555-568

Published Date: 5 February 2019

The benefit of taxane-based therapies over fluoropyrimidine plus platinum (FP) in the treatment of esophageal cancer: a meta-analysis of clinical studies

Wang T, Yu J, Liu M, Chen Y, Zhu C, Lu L, Wang M, Min L, Liu X, Zhang X, Gubat JA, Chen Y

Drug Design, Development and Therapy 2019, 13:539-553

Published Date: 5 February 2019

Safety and efficacy of atezolizumab in the treatment of cancers: a systematic review and pooled-analysis

Tie Y, Yang H, Zhao R, Zheng H, Yang D, Zhao J, Liu M

Drug Design, Development and Therapy 2019, 13:523-538

Published Date: 4 February 2019

Bisperoxovanadium protects against spinal cord injury by regulating autophagy via activation of ERK1/2 signaling

Tang Y, Li K, Yang C, Huang K, Zhou J, Shi Y, Xie K, Liu J

Drug Design, Development and Therapy 2019, 13:513-521

Published Date: 1 February 2019

A nucleoside-sparing regimen of dolutegravir plus ritonavir-boosted atazanavir in HIV-1-infected patients with virological failure: the DOLATAV study

Spagnuolo V, Galli L, Poli A, Bigoloni A, Fumagalli L, Gianotti N, Nozza S, Ferrari D, Locatelli M, Lazzarin A, Castagna A

Drug Design, Development and Therapy 2019, 13:477-479

Published Date: 24 January 2019

Qingxin kaiqiao fang ameliorates memory impairment and inhibits apoptosis in APP/PS1 double transgenic mice through the MAPK pathway

Gao SY, Lin J, Wang T, Shen Y, Li Y, Yang W, Zhou K, Hu H

Drug Design, Development and Therapy 2019, 13:459-475

Published Date: 23 January 2019

Structure–activity relationship of an antimicrobial peptide, Phylloseptin-PHa: balance of hydrophobicity and charge determines the selectivity of bioactivities

Liu Y, Du Q, Ma C, Xi X, Wang L, Zhou M, Burrows JF, Chen T, Wang H

Drug Design, Development and Therapy 2019, 13:447-458

Published Date: 23 January 2019

MicroRNA-339 inhibits human hepatocellular carcinoma proliferation and invasion via targeting ZNF689

Zeng H, Zheng J, Wen S, Luo J, Shao G, Zhang Y

Drug Design, Development and Therapy 2019, 13:435-445

Published Date: 22 January 2019

Design, synthesis, and biologic evaluation of novel chrysin derivatives as cytotoxic agents and caspase-3/7 activators

Al-Oudat BA, Alqudah MA, Audat SA, Al-Balas QA, El-Elimat T, Hassan MA, Frhat IN, Azaizeh MM

Drug Design, Development and Therapy 2019, 13:423-433

Published Date: 22 January 2019

A real-life experience of sorafenib treatment for patients with advanced hepatocellular carcinoma: a retrospective analysis at Cathay General Hospital, 2007–2015

Huang CC, Chen HY, Chang RH, Liao PA, Lien HH, Hung CS, Yang SS, Hu JT

Drug Design, Development and Therapy 2019, 13:397-404

Published Date: 22 January 2019

Screening of novel HSP-inducing compounds to conserve cardiomyocyte function in experimental atrial fibrillation

van Marion DMS, Hu X, Zhang D, Hoogstra-Berends F, Seerden JPG, Loen L, Heeres A, Steen H, Henning RH, Brundel BJJM

Drug Design, Development and Therapy 2019, 13:345-364

Published Date: 18 January 2019

YB-1 modulates the drug resistance of glioma cells by activation of MDM2/p53 pathway

Tong H, Zhao K, Zhang J, Zhu J, Xiao J

Drug Design, Development and Therapy 2019, 13:317-326

Published Date: 14 January 2019

A brief report of toxicity end points of HER2 vaccines for the treatment of patients with HER2+ breast cancer

Costa R, Zaman S, Sharpe S, Helenowski I, Shaw C, Han H, Soliman H, Czerniecki B

Drug Design, Development and Therapy 2019, 13:309-316

Published Date: 14 January 2019

Antistaphylococcal evaluation of indole–naphthalene hybrid analogs

Ashraf K, Yasrebi K, Adeniyi ET, Hertlein T, Ohlsen K, Lalk M, Erdmann F, Hilgeroth A

Drug Design, Development and Therapy 2019, 13:275-283

Published Date: 10 January 2019

Catalpol prevents denervated muscular atrophy related to the inhibition of autophagy and reduces BAX/BCL2 ratio via mTOR pathway

Wang Y, Shao YL, Gao YQ, Wan GR, Wan D, Zhu HF, Qiu Y, Ye XY

Drug Design, Development and Therapy 2019, 13:243-253

Published Date: 31 December 2018

A colon-specific prodrug of metoclopramide ameliorates colitis in an experimental rat model

Yang Y, Kim W, Kim D, Jeong S, Yoo JW, Jung Y

Drug Design, Development and Therapy 2019, 13:231-242

Published Date: 28 December 2018

Xyloketal derivative C53N protects against mild traumatic brain injury in mice

Liang F, Su F, Wang X, Long S, Zheng Y, He X, Pang J, Pei Z

Drug Design, Development and Therapy 2019, 13:173-182

Published Date: 27 December 2018

Urapidil, compared to nitroglycerin, has better clinical safety in the treatment of hypertensive patients with acute heart failure: a meta-analysis

Shi J, Li Y, Xing C, Peng P, Shi H, Ding H, Zheng P, Ning G, Feng S

Drug Design, Development and Therapy 2019, 13:161-172

Published Date: 27 December 2018

Fenofibrate modified-release pellets with lag phase and high oral bioavailability

Li F, Zheng X, Bao YC, Chen T, Zeng J, Xu XL, Yan C, Feng LL

Drug Design, Development and Therapy 2019, 13:141-151

Published Date: 24 December 2018

Tetrandrine suppresses cervical cancer growth by inducing apoptosis in vitro and in vivo

Zhang H, Xie B, Zhang Z, Sheng X, Zhang S

Drug Design, Development and Therapy 2019, 13:119-127

Published Date: 20 December 2018

Tocilizumab in the treatment of rheumatoid arthritis: an evidence-based review and patient selection

Biggioggero M, Crotti C, Becciolini A, Favalli EG

Drug Design, Development and Therapy 2019, 13:57-70

Published Date: 19 December 2018

Ocular side effects of levitra® (vardenafil) – results of a double-blind crossover study in healthy male subjects

Roessler G, Vobig M, Walter P, Mazinani BAE

Drug Design, Development and Therapy 2019, 13:37-43

Published Date: 18 December 2018

Multimetal organic frameworks as drug carriers: aceclofenac as a drug candidate

Al Haydar M, Abid HR, Sunderland B, Wang S

Drug Design, Development and Therapy 2019, 13:23-35

Published Date: 18 December 2018

Cytoprotective effects of molsidomine against methotrexate-induced hepatotoxicity: an experimental rat study

Samdanci ET, Huz M, Ozhan O, Tanbek K, Pamukcu E, Akatli AN, Parlakpinar H

Drug Design, Development and Therapy 2019, 13:13-21

Published Date: 20 December 2018