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Drug Design, Development and Therapy


Archive: Volume 13, 2019

The TwistDock workflow for evaluation of bivalent Smac mimetics targeting XIAP

Huang Q, Peng Y, Peng Y, Wei D, Wei Y, Feng S

Drug Design, Development and Therapy 2019, 13:1373-1388

Published Date: 26 April 2019

Clinical efficacy of 60-mg dexlansoprazole and 40-mg esomeprazole after 24 weeks for the on-demand treatment of gastroesophageal reflux disease grades A and B: a prospective randomized trial

Chiang HH, Wu DC, Hsu PI, Kuo CH, Tai WC, Yang SC, Wu KL, Yao CC, Tsai CE, Liang CM, Wang YK, Wang JW, Huang CF, Chuah SK

Drug Design, Development and Therapy 2019, 13:1347-1356

Published Date: 26 April 2019

Caffeic acid phenethyl ester suppressed growth and metastasis of nasopharyngeal carcinoma cells by inactivating the NF-κB pathway

Liang Y, Feng G, Wu L, Zhong S, Gao X, Tong Y, Cui W, Qin Y, Xu WQ, Xiao X, Zhang Z, Huang G, Zhou X

Drug Design, Development and Therapy 2019, 13:1335-1345

Published Date: 26 April 2019

Epigallocatechin-3-gallate enhances the osteoblastogenic differentiation of human adipose-derived stem cells

Zhang J, Wu K, Xu T, Wu J, Li P, Wang H, Wu H, Wu G

Drug Design, Development and Therapy 2019, 13:1311-1321

Published Date: 23 April 2019

Effects of dezocine for the prevention of postoperative catheter-related bladder discomfort: a prospective randomized trial

Zhang GF, Guo J, Qiu LL, Li SM, Zheng M, Xia JY, Yang JJ

Drug Design, Development and Therapy 2019, 13:1281-1288

Published Date: 23 April 2019

Pharmacokinetics and pharmacodynamics of the novel Nrf2 activator omaveloxolone in primates

Reisman SA, Gahir SS, Lee CY, Proksch JW, Sakamoto M, Ward KW

Drug Design, Development and Therapy 2019, 13:1259-1270

Published Date: 17 April 2019

The molecular mechanisms of Aloin induce gastric cancer cells apoptosis by targeting High Mobility Group Box 1

Tao H, Tang T, Wang S, Wang Z, Ma Y, Cai T, Cheng X, Qi S, Zhang Y, Qi Z

Drug Design, Development and Therapy 2019, 13:1221-1231

Published Date: 17 April 2019

Effect of butorphanol on etomidate-induced myoclonus: a systematic review and meta-analysis

Hua J, Miao S, Shi M, Tu Q, Wang X, Liu S, Wang G, Gan J

Drug Design, Development and Therapy 2019, 13:1213-1220

Published Date: 16 April 2019

Beneficial effects of resveratrol and exercise training on cardiac and aortic function and structure in the 3xTg mouse model of Alzheimer’s disease

Esfandiarei M, Hoxha B, Talley NA, Anderson MR, Alkhouli MF, Squire MA, Eckman DM, Babu JR, Lopaschuk GD, Broderick TL

Drug Design, Development and Therapy 2019, 13:1197-1211

Published Date: 17 April 2019

Tetramethylpyrazine attenuated bupivacaine-induced neurotoxicity in SH-SY5Y cells through regulating apoptosis, autophagy and oxidative damage

Wang S, Xia B, Qiao Z, Duan L, Wang G, Meng W, Liu Z, Wang Y, Zhang M

Drug Design, Development and Therapy 2019, 13:1187-1196

Published Date: 17 April 2019

Effect of umbelliferone on adjuvant-induced arthritis in rats by MAPK/NF-κB pathway

Ouyang L, Dan Y, Shao Z, Yang S, Yang C, Liu G, Zhou W, Duan D

Drug Design, Development and Therapy 2019, 13:1163-1170

Published Date: 11 April 2019

Quizartinib (AC220): a promising option for acute myeloid leukemia

Zhou F, Ge Z, Chen B

Drug Design, Development and Therapy 2019, 13:1117-1125

Published Date: 8 April 2019

A novel hybrid compound LLP2A-alendronate accelerates open fracture healing in a rabbit model

Wang Z, Zhao Y, Zhang D, Qi B, Xiao W, Hu X, Yu A

Drug Design, Development and Therapy 2019, 13:1077-1086

Published Date: 5 April 2019

Systematic elucidation of the mechanism of geraniol via network pharmacology

Zhang YF, Huang Y, Ni YH, Xu ZM

Drug Design, Development and Therapy 2019, 13:1069-1075

Published Date: 4 April 2019

Transportan-derived cell-penetrating peptide delivers siRNA to inhibit replication of influenza virus in vivo

Zhang C, Ren W, Liu Q, Tan Z, Li J, Tong C

Drug Design, Development and Therapy 2019, 13:1059-1068

Published Date: 4 April 2019

Formulation and bioequivalence studies of choline alfoscerate tablet comparing with soft gelatin capsule in healthy male volunteers

Min MH, Park JH, Hur JH, Shin HC, Cho YJ, Kim DD

Drug Design, Development and Therapy 2019, 13:1049-1058

Published Date: 5 April 2019

Metabolism of remimazolam in primary human hepatocytes during continuous long-term infusion in a 3-D bioreactor system

Freyer N, Knöspel F, Damm G, Greuel S, Schneider C, Seehofer D, Stöhr T, Petersen KU, Zeilinger K

Drug Design, Development and Therapy 2019, 13:1033-1047

Published Date: 2 April 2019

Jinlong capsule inhibits migration and invasion in human glioblastoma cells via the modulation of mTOR/S6 signaling pathway

Shi J, Zhang W, He L, Kong F, Pan M, Guo J, Xu X, Guo J, Wang H, Wang Y

Drug Design, Development and Therapy 2019, 13:1023-1032

Published Date: 1 April 2019

Efficacy and safety of paricalcitol in patients undergoing hemodialysis: a meta-analysis

Liu Y, Liu LY, Jia Y, Wu MY, Sun YY, Ma FZ

Drug Design, Development and Therapy 2019, 13:999-1009

Published Date: 28 March 2019

Emodin alleviates myocardial ischemia/reperfusion injury by inhibiting gasdermin D-mediated pyroptosis in cardiomyocytes

Ye B, Chen X, Dai S, Han J, Liang X, Lin S, Cai X, Huang Z, Huang W

Drug Design, Development and Therapy 2019, 13:975-990

Published Date: 25 March 2019

Mechanistic research holds promise for bacterial vaccines and phage therapies for Pseudomonas aeruginosa

Hoggarth A, Weaver A, Pu Q, Huang T, Schettler J, Chen F, Yuan X, Wu M

Drug Design, Development and Therapy 2019, 13:909-924

Published Date: 20 March 2019

Protective role of quercetin against manganese-induced injury in the liver, kidney, and lung; and hematological parameters in acute and subchronic rat models [Retraction]

Bahar E, Lee GH, Bhattarai KR, Lee HY, Kim HK, Handigund M, Choi MK, Han SY, Chae HJ, Yoon H

Drug Design, Development and Therapy 2019, 13:907-908

Published Date: 18 March 2019

Drug-release system of microchannel transport used in minimally invasive surgery for hemostasis

Huang H, Liu H, Zhou H, Liang Z, Song D, Zhang Y, Huang W, Zhao X, Wu B, Ye G, Huang Y

Drug Design, Development and Therapy 2019, 13:881-896

Published Date: 12 March 2019

Efficacy and safety of tacrolimus in induction therapy of patients with lupus nephritis

Zhou TB, Lin SJ, Yang S, Lin WS

Drug Design, Development and Therapy 2019, 13:857-869

Published Date: 12 March 2019

Clinical efficacy and safety of rituximab in lupus nephritis

Zhong Z, Li H, Zhong H, Zhou T

Drug Design, Development and Therapy 2019, 13:845-856

Published Date: 11 March 2019

Single-use suvorexant for treating insomnia during overnight polysomnography in patients with suspected obstructive sleep apnea: a single-center experience

Matsumura T, Terada J, Yoshimura C, Koshikawa K, Kinoshita T, Yahaba M, Nagashima K, Sakao S, Tatsumi K

Drug Design, Development and Therapy 2019, 13:809-816

Published Date: 28 February 2019

Utility of nintedanib for severe idiopathic pulmonary fibrosis: a single-center retrospective study [Corrigendum]

Abe M, Tsushima K, Sakayori M, Suzuki K, Ikari J, Terada J, Tatsumi K

Drug Design, Development and Therapy 2019, 13:807-808

Published Date: 28 February 2019

Physicochemical characterization and phase I study of CMAB008, an infliximab biosimilar produced by a different expression system

An Q, Zheng Y, Zhao Y, Liu T, Guo H, Zhang D, Qian W, Wang H, Guo Y, Hou S, Li J

Drug Design, Development and Therapy 2019, 13:791-805

Published Date: 12 March 2019

Synthesis, structure elucidation, and antifungal potential of certain new benzodioxole–imidazole molecular hybrids bearing ester functionalities

Al-Wabli RI, Al-Ghamdi AR, Ghabbour HA, Al-Agamy MH, Attia MI

Drug Design, Development and Therapy 2019, 13:775-789

Published Date: 26 February 2019

Ginkgolide B ameliorates myocardial ischemia reperfusion injury in rats via inhibiting endoplasmic reticulum stress

Guo C, Zhang J, Zhang P, Si A, Zhang Z, Zhao L, Lv F, Zhao G

Drug Design, Development and Therapy 2019, 13:767-774

Published Date: 26 February 2019

Monosialoganglioside protects against bupivacaine-induced neurotoxicity caused by endoplasmic reticulum stress in rats

Liu B, Ji J, Feng Q, Luo X, Yan X, Ni Y, He Y, Mao Z, Liu J

Drug Design, Development and Therapy 2019, 13:707-718

Published Date: 19 February 2019

Dexmedetomidine attenuates the neurotoxicity of propofol toward primary hippocampal neurons in vitro via Erk1/2/CREB/BDNF signaling pathways

Tu Y, Liang Y, Xiao Y, Lv J, Guan R, Xiao F, Xie Y, Xiao Q

Drug Design, Development and Therapy 2019, 13:695-706

Published Date: 19 February 2019

Synthesis of budesonide conjugates and their anti-inflammatory effects: a preliminary study

Yan Y, Wang P, Li R, Sun Y, Zhang R, Huo C, Xing J, Dong Y

Drug Design, Development and Therapy 2019, 13:681-694

Published Date: 19 February 2019

Update in treatment of uveitic macular edema

Koronis S, Stavrakas P, Balidis M, Kozeis N, Tranos PG

Drug Design, Development and Therapy 2019, 13:667-680

Published Date: 19 February 2019

Ginkgo biloba extract-761 protects myocardium by regulating Akt/Nrf2 signal pathway

Chen X, Ren S, Dong J, Qiu C, Chen Y, Tao H

Drug Design, Development and Therapy 2019, 13:647-655

Published Date: 13 February 2019

Epigallocatechin-3-gallate in the prevention and treatment of hepatocellular carcinoma: experimental findings and translational perspectives

Bimonte S, Albino V, Piccirillo M, Nasto A, Molino C, Palaia R, Cascella M

Drug Design, Development and Therapy 2019, 13:611-621

Published Date: 12 February 2019

Emodin induces apoptosis and autophagy of fibroblasts obtained from patient with ankylosing spondylitis

Ma C, Wen B, Zhang Q, Shao P, Gu W, Qu K, Shi Y, Wang B

Drug Design, Development and Therapy 2019, 13:601-609

Published Date: 11 February 2019

The underlying mechanisms of Jie-Du-Hua-Yu granule for protecting rat liver failure

Qiu H, Mao D, Tang N, Long F, Zhang R, Wang M, Shi Q, Li J, Jiang Q, Chen Y, Wang X

Drug Design, Development and Therapy 2019, 13:589-600

Published Date: 11 February 2019

Cathepsin G cleaves and activates IL-36γ and promotes the inflammation of psoriasis

Guo J, Tu J, Hu YY, Song GX, Yin ZQ

Drug Design, Development and Therapy 2019, 13:581-588

Published Date: 8 February 2019

Efficacy of a recombinant single-chain fragment variable region, VasSF, as a new drug for vasculitis

Kameoka Y, Kishi F, Koura M, Yamakawa Y, Nagasawa R, Ito F, Matsuda J, Suzuki O, Nakayama T, Suzuki K

Drug Design, Development and Therapy 2019, 13:555-568

Published Date: 5 February 2019

The benefit of taxane-based therapies over fluoropyrimidine plus platinum (FP) in the treatment of esophageal cancer: a meta-analysis of clinical studies

Wang T, Yu J, Liu M, Chen Y, Zhu C, Lu L, Wang M, Min L, Liu X, Zhang X, Gubat JA, Chen Y

Drug Design, Development and Therapy 2019, 13:539-553

Published Date: 5 February 2019

Safety and efficacy of atezolizumab in the treatment of cancers: a systematic review and pooled-analysis

Tie Y, Yang H, Zhao R, Zheng H, Yang D, Zhao J, Liu M

Drug Design, Development and Therapy 2019, 13:523-538

Published Date: 4 February 2019

Bisperoxovanadium protects against spinal cord injury by regulating autophagy via activation of ERK1/2 signaling

Tang Y, Li K, Yang C, Huang K, Zhou J, Shi Y, Xie K, Liu J

Drug Design, Development and Therapy 2019, 13:513-521

Published Date: 1 February 2019

A nucleoside-sparing regimen of dolutegravir plus ritonavir-boosted atazanavir in HIV-1-infected patients with virological failure: the DOLATAV study

Spagnuolo V, Galli L, Poli A, Bigoloni A, Fumagalli L, Gianotti N, Nozza S, Ferrari D, Locatelli M, Lazzarin A, Castagna A

Drug Design, Development and Therapy 2019, 13:477-479

Published Date: 24 January 2019

Qingxin kaiqiao fang ameliorates memory impairment and inhibits apoptosis in APP/PS1 double transgenic mice through the MAPK pathway

Gao SY, Lin J, Wang T, Shen Y, Li Y, Yang W, Zhou K, Hu H

Drug Design, Development and Therapy 2019, 13:459-475

Published Date: 23 January 2019

Structure–activity relationship of an antimicrobial peptide, Phylloseptin-PHa: balance of hydrophobicity and charge determines the selectivity of bioactivities

Liu Y, Du Q, Ma C, Xi X, Wang L, Zhou M, Burrows JF, Chen T, Wang H

Drug Design, Development and Therapy 2019, 13:447-458

Published Date: 23 January 2019

MicroRNA-339 inhibits human hepatocellular carcinoma proliferation and invasion via targeting ZNF689

Zeng H, Zheng J, Wen S, Luo J, Shao G, Zhang Y

Drug Design, Development and Therapy 2019, 13:435-445

Published Date: 22 January 2019

Design, synthesis, and biologic evaluation of novel chrysin derivatives as cytotoxic agents and caspase-3/7 activators

Al-Oudat BA, Alqudah MA, Audat SA, Al-Balas QA, El-Elimat T, Hassan MA, Frhat IN, Azaizeh MM

Drug Design, Development and Therapy 2019, 13:423-433

Published Date: 22 January 2019

A real-life experience of sorafenib treatment for patients with advanced hepatocellular carcinoma: a retrospective analysis at Cathay General Hospital, 2007–2015

Huang CC, Chen HY, Chang RH, Liao PA, Lien HH, Hung CS, Yang SS, Hu JT

Drug Design, Development and Therapy 2019, 13:397-404

Published Date: 22 January 2019

Screening of novel HSP-inducing compounds to conserve cardiomyocyte function in experimental atrial fibrillation

van Marion DMS, Hu X, Zhang D, Hoogstra-Berends F, Seerden JPG, Loen L, Heeres A, Steen H, Henning RH, Brundel BJJM

Drug Design, Development and Therapy 2019, 13:345-364

Published Date: 18 January 2019

YB-1 modulates the drug resistance of glioma cells by activation of MDM2/p53 pathway

Tong H, Zhao K, Zhang J, Zhu J, Xiao J

Drug Design, Development and Therapy 2019, 13:317-326

Published Date: 14 January 2019

A brief report of toxicity end points of HER2 vaccines for the treatment of patients with HER2+ breast cancer

Costa R, Zaman S, Sharpe S, Helenowski I, Shaw C, Han H, Soliman H, Czerniecki B

Drug Design, Development and Therapy 2019, 13:309-316

Published Date: 14 January 2019

Antistaphylococcal evaluation of indole–naphthalene hybrid analogs

Ashraf K, Yasrebi K, Adeniyi ET, Hertlein T, Ohlsen K, Lalk M, Erdmann F, Hilgeroth A

Drug Design, Development and Therapy 2019, 13:275-283

Published Date: 10 January 2019

Catalpol prevents denervated muscular atrophy related to the inhibition of autophagy and reduces BAX/BCL2 ratio via mTOR pathway

Wang Y, Shao YL, Gao YQ, Wan GR, Wan D, Zhu HF, Qiu Y, Ye XY

Drug Design, Development and Therapy 2019, 13:243-253

Published Date: 31 December 2018

A colon-specific prodrug of metoclopramide ameliorates colitis in an experimental rat model

Yang Y, Kim W, Kim D, Jeong S, Yoo JW, Jung Y

Drug Design, Development and Therapy 2019, 13:231-242

Published Date: 28 December 2018

Xyloketal derivative C53N protects against mild traumatic brain injury in mice

Liang F, Su F, Wang X, Long S, Zheng Y, He X, Pang J, Pei Z

Drug Design, Development and Therapy 2019, 13:173-182

Published Date: 27 December 2018

Urapidil, compared to nitroglycerin, has better clinical safety in the treatment of hypertensive patients with acute heart failure: a meta-analysis

Shi J, Li Y, Xing C, Peng P, Shi H, Ding H, Zheng P, Ning G, Feng S

Drug Design, Development and Therapy 2019, 13:161-172

Published Date: 27 December 2018

Fenofibrate modified-release pellets with lag phase and high oral bioavailability

Li F, Zheng X, Bao YC, Chen T, Zeng J, Xu XL, Yan C, Feng LL

Drug Design, Development and Therapy 2019, 13:141-151

Published Date: 24 December 2018

Tetrandrine suppresses cervical cancer growth by inducing apoptosis in vitro and in vivo

Zhang H, Xie B, Zhang Z, Sheng X, Zhang S

Drug Design, Development and Therapy 2019, 13:119-127

Published Date: 20 December 2018

Tocilizumab in the treatment of rheumatoid arthritis: an evidence-based review and patient selection

Biggioggero M, Crotti C, Becciolini A, Favalli EG

Drug Design, Development and Therapy 2019, 13:57-70

Published Date: 19 December 2018

Ocular side effects of levitra® (vardenafil) – results of a double-blind crossover study in healthy male subjects

Roessler G, Vobig M, Walter P, Mazinani BAE

Drug Design, Development and Therapy 2019, 13:37-43

Published Date: 18 December 2018

Multimetal organic frameworks as drug carriers: aceclofenac as a drug candidate

Al Haydar M, Abid HR, Sunderland B, Wang S

Drug Design, Development and Therapy 2019, 13:23-35

Published Date: 18 December 2018

Cytoprotective effects of molsidomine against methotrexate-induced hepatotoxicity: an experimental rat study

Samdanci ET, Huz M, Ozhan O, Tanbek K, Pamukcu E, Akatli AN, Parlakpinar H

Drug Design, Development and Therapy 2019, 13:13-21

Published Date: 20 December 2018