Back to Journals » Drug Design, Development and Therapy » Volume 8

Drug Design, Development and Therapy


Archive: Volume 8, 2014

Xyloketal B, a marine compound, acts on a network of molecular proteins and regulates the activity and expression of rat cytochrome P450 3a: a bioinformatic and animal study

Su JH, Chang C, Xiang Q, Zhou ZW, Luo R, Yang L, He ZX, Yang HT, Li J, Bei Y, Xu JM, Zhang MJ, Zhang QH, Su ZJ, Huang YD, Pang JY, Zhou SF

Drug Design, Development and Therapy 2014, 8:2555-2602

Published Date: 12 December 2014

Curative treatment can be an option for patients with metastatic squamous cell cancer of the head and neck

Guenne C, Fayette J, Cosmidis A, Fuchsmann C, Tartas S, Favrel V, Céruse P

Drug Design, Development and Therapy 2014, 8:2549-2553

Published Date: 12 December 2014

Stevens–Johnson Syndrome and toxic epidermalnecrolysis: a multi-aspect comparative 7-year study from the People’s Republic of China

Sun J, Liu J, Gong QL, Ding GZ, Ma LW, Zhang LC, Lu Y

Drug Design, Development and Therapy 2014, 8:2539-2547

Published Date: 12 December 2014

Treatment of port wine stains with pulsed dye laser: a retrospective study of 848 cases in Shandong Province, People’s Republic of China

Shi W, Wang J, Lin Y, Geng J, Wang H, Gong Y, Liu H, Zhang F

Drug Design, Development and Therapy 2014, 8:2531-2538

Published Date: 12 December 2014

Sequential treatment with AT-101 enhances cisplatin chemosensitivity in human non-small cell lung cancer cells through inhibition of apurinic/apyrimidinic endonuclease 1-activated IL-6/STAT3 signaling pathway

Ren T, Shan J, Qing Y, Qian C, Li Q, Lu G, Li M, Li C, Peng Y, Luo H, Zhang S, Zhang W, Wang D, Zhou SF

Drug Design, Development and Therapy 2014, 8:2517-2529

Published Date: 12 December 2014

A new recombinant factor VIII: from genetics to clinical use

Santagostino E

Drug Design, Development and Therapy 2014, 8:2507-2515

Published Date: 12 December 2014

Dapagliflozin for the treatment of type 2 diabetes: a review of the literature

Saeed MA, Narendran P

Drug Design, Development and Therapy 2014, 8:2493-2505

Published Date: 10 December 2014

Scientometrics of anesthetic drugs and their techniques of administration, 1984–2013

Vlassakov KV, Kissin I

Drug Design, Development and Therapy 2014, 8:2463-2473

Published Date: 9 December 2014

Mesenchymal stem cell-based NK4 gene therapy in nude mice bearing gastric cancer xenografts

Zhu Y, Cheng M, Yang Z, Zeng CY, Chen J, Xie Y, Luo SW, Zhang KH, Zhou SF, Lu NH

Drug Design, Development and Therapy 2014, 8:2449-2462

Published Date: 9 December 2014

Matrix-induced autologous chondrocyte implantation for the treatment of chondral defects of the knees in Chinese patients

Zhang ZW, Zhong X, Ji HR, Tang ZB, Bai JP, Yao MM, Hou JL, Zheng MH, Wood D, Sun JZ, Zhou SF, Liu AB

Drug Design, Development and Therapy 2014, 8:2439-2448

Published Date: 5 December 2014

Clinicopathological significance and potential drug target of RUNX3 in breast cancer

Yu YY, Chen C, Kong FF, Zhang W

Drug Design, Development and Therapy 2014, 8:2423-2430

Published Date: 5 December 2014

Cisplatin-induced hyponatremia in malignancy: comparison between brand-name and generic formulation

Ochi N, Yamane H, Hotta K, Fujii H, Isozaki H, Honda Y, Yamagishi T, Kubo T, Tanimoto M, Kiura K, Takigawa N

Drug Design, Development and Therapy 2014, 8:2401-2408

Published Date: 3 December 2014

Drug development strategies for the treatment of obesity: how to ensure efficacy, safety, and sustainable weight loss

Barja-Fernandez S, Leis R, Casanueva FF, Seoane LM

Drug Design, Development and Therapy 2014, 8:2391-2400

Published Date: 1 December 2014

Discovery of potential drugs for human-infecting H7N9 virus containing R294K mutation

He JY, Li C, Wu G

Drug Design, Development and Therapy 2014, 8:2377-2390

Published Date: 1 December 2014

Scleral melt following Retisert intravitreal fluocinolone implant

Georgalas I, Koutsandrea C, Papaconstantinou D, Mpouritis D, Petrou P

Drug Design, Development and Therapy 2014, 8:2373-2375

Published Date: 28 November 2014

CCL19 and CCL21 modulate the inflammatory milieu in atherosclerotic lesions

Akhavanpoor M, Gleissner CA, Gorbatsch S, Doesch AO, Akhavanpoor H, Wangler S, Jahn F, Lasitschka F, Katus HA, Erbel C

Drug Design, Development and Therapy 2014, 8:2359-2371

Published Date: 27 November 2014

Interleukin 1 inhibition with anakinra in adult-onset Still disease: a meta-analysis of its efficacy and safety

Hong D, Yang Z, Han SY, Liang X, Ma K, Zhang X

Drug Design, Development and Therapy 2014, 8:2345-2357

Published Date: 25 November 2014

Characterization and in vitro studies of the anticancer effect of oxidized carbon nanotubes functionalized with betulinic acid

Tan JM, Karthivashan G, Arulselvan P, Fakurazi S, Hussein MZ

Drug Design, Development and Therapy 2014, 8:2333-2343

Published Date: 20 November 2014

Pilot Phase II study of mazindol in children with attention deficit/hyperactivity disorder

Konofal E, Zhao W, Laouénan C, Lecendreux M, Kaguelidou F, Benadjaoud L, Mentré F, Jacqz-Aigrain E

Drug Design, Development and Therapy 2014, 8:2321-2332

Published Date: 11 December 2014

Choosing preclinical study models of diabetic retinopathy: key problems for consideration

Mi XS, Yuan TF, Ding Y, Zhong JX, So KF

Drug Design, Development and Therapy 2014, 8:2311-2319

Published Date: 18 November 2014

Leptin signaling molecular actions and drug target in hepatocellular carcinoma

Jiang N, Sun R, Sun Q

Drug Design, Development and Therapy 2014, 8:2295-2302

Published Date: 14 November 2014

Inhibition of cardiac Kv1.5 potassium current by the anesthetic midazolam: mode of action

Vonderlin N, Fischer F, Zitron E, Seyler C, Scherer D, Thomas D, Katus HA, Scholz EP

Drug Design, Development and Therapy 2014, 8:2263-2271

Published Date: 7 November 2014

Identification of novel multitargeted PPARα/γ/δ pan agonists by core hopping of rosiglitazone

Wang XJ, Zhang J, Wang SQ, Xu WR, Cheng XC, Wang RL

Drug Design, Development and Therapy 2014, 8:2255-2262

Published Date: 7 November 2014

Women taking the “blue pill” (sildenafil citrate): such a big deal?

Lo Monte G, Graziano A, Piva I, Marci R

Drug Design, Development and Therapy 2014, 8:2251-2254

Published Date: 7 November 2014

Early non-steady-state population pharmacokinetics of oral cyclosporine in renal transplant recipients

Baek H, Han S, Yim DS, Kim SJ, Lee SY, Jang HR, Lee JE, Kim DJ, Kim YG, Oh HY, Huh W

Drug Design, Development and Therapy 2014, 8:2241-2249

Published Date: 7 November 2014

Caval filters in intensive care: a retrospective study

Ferraro F, Di Gennaro TL, Torino A, Petruzzi J, d'Elia A, Fusco P, Marfella R, Lettieri B

Drug Design, Development and Therapy 2014, 8:2213-2219

Published Date: 6 November 2014

Involvement of NF-ΚB and HSP70 signaling pathways in the apoptosis of MDA-MB-231 cells induced by a prenylated xanthone compound, α-mangostin, from Cratoxylum arborescens

Ibrahim MY, Hashim NM, Mohan S, Abdulla MA, Abdelwahab SI, Kamalidehghan B, Ghaderian M, Dehghan F, Ali LZ, Karimian H, Yahayu M, Ee GCL, Farjam AS, Ali HM

Drug Design, Development and Therapy 2014, 8:2193-2211

Published Date: 6 November 2014

Discovery and evaluation of novel anti-inflammatory derivatives of natural bioactive curcumin

Zhang Y, Jiang X, Peng K, Chen C, Fu L, Wang Z, Feng J, Liu Z, Zhang H, Liang G, Pan Z

Drug Design, Development and Therapy 2014, 8:2161-2171

Published Date: 4 November 2014

Functional analysis of tanshinone IIA that blocks the redox function of human apurinic/apyrimidinic endonuclease 1/redox factor-1

Sui J, Li M, Qian C, Wang S, Cheng Y, Chen BP, Wang D

Drug Design, Development and Therapy 2014, 8:2147-2160

Published Date: 3 November 2014

Effect of honokiol on the induction of drug-metabolizing enzymes in human hepatocytes

Cho YY, Jeong HU, Kim JH, Lee HS

Drug Design, Development and Therapy 2014, 8:2137-2145

Published Date: 3 November 2014

Clinicopathological significance and potential drug target of p15INK4B in multiple myeloma

Li J, Bi L, Lin Y, Lu Z, Hou G

Drug Design, Development and Therapy 2014, 8:2129-2136

Published Date: 31 October 2014

Curcumin could reduce the monomer of TTR with Tyr114Cys mutation via autophagy in cell model of familial amyloid polyneuropathy

Li H, Zhang Y, Cao L, Xiong R, Zhang B, Wu L, Zhao Z, Chen SD

Drug Design, Development and Therapy 2014, 8:2121-2128

Published Date: 31 October 2014

The influence of goal-directed fluid therapy on the prognosis of elderly patients with hypertension and gastric cancer surgery

Zeng K, Li YZ, Liang M, Gao YG, Cai HD, Lin CZ

Drug Design, Development and Therapy 2014, 8:2113-2119

Published Date: 29 October 2014

Gastroprotective activity of Annona muricata leaves against ethanol-induced gastric injury in rats via Hsp70/Bax involvement

Moghadamtousi SZ, Rouhollahi E, Karimian H, Fadaeinasab M, Abdulla MA, Kadir HA

Drug Design, Development and Therapy 2014, 8:2099-2111

Published Date: 28 October 2014

The role of ketotifen in the prevention of testicular damage in rats with experimental unilateral undescended testes

Acikgoz A, Asci R, Aydin O, Çavuş H, Donmez G, Buyukalpelli R

Drug Design, Development and Therapy 2014, 8:2089-2097

Published Date: 23 October 2014

Effects of caffeic acid phenethyl ester on palatal mucosal defects and tooth extraction sockets

Günay A, Arpağ OF, Atilgan S, Yaman F, Atalay Y, Acikan I

Drug Design, Development and Therapy 2014, 8:2069-2074

Published Date: 23 October 2014

Safety and efficacy of peramivir for influenza treatment

Hata A, Akashi-Ueda R, Takamatsu K, Matsumura T

Drug Design, Development and Therapy 2014, 8:2017-2038

Published Date: 24 October 2014

Immunomodulatory effects of 17-O-acetylacuminolide in RAW264.7 cells and HUVECs: involvement of MAPK and NF-κB pathways

Achoui M, Heyninck K, Looi CY, Mustafa AM, Haegeman G, Mustafa MR

Drug Design, Development and Therapy 2014, 8:1993-2007

Published Date: 20 October 2014

Risk factors associated with ineligibility of adjuvant cisplatin-based chemotherapy after nephroureterectomy

Shao IH, Lin YH, Hou CP, Juang HH, Chen CL, Chang PL, Tsui KH

Drug Design, Development and Therapy 2014, 8:1985-1991

Published Date: 21 October 2014

Intestinal absorption, organ distribution, and urinary excretion of the rare sugar D-psicose

Tsukamoto I, Hossain A, Yamaguchi F, Hirata Y, Dong Y, Kamitori K, Sui L, Nonaka M, Ueno M, Nishimoto K, Suda H, Morimoto K, Shimonishi T, Saito M, Song T, Konishi R, Tokuda M

Drug Design, Development and Therapy 2014, 8:1955-1964

Published Date: 17 October 2014

Indole and synthetic derivative activate chaperone expression to reduce polyQ aggregation in SCA17 neuronal cell and slice culture models

Kung PJ, Tao YC, Hsu HC, Chen WL, Lin TH, Janreddy D, Yao CF, Chang KH, Lin JY, Su MT, Wu CH, Lee-Chen GJ, Hsieh-Li HM

Drug Design, Development and Therapy 2014, 8:1929-1939

Published Date: 16 October 2014

Influence of caffeine and hyaluronic acid on collagen biosynthesis in human skin fibroblasts

Donejko M, Przylipiak A, Rysiak E, Głuszuk K, Surażyński A

Drug Design, Development and Therapy 2014, 8:1923-1928

Published Date: 15 October 2014

Multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer’s disease: design, synthesis, biochemical evaluation, ADMET, molecular modeling, and QSAR analysis of novel donepezil-pyridyl hybrids

Bautista-Aguilera OM, Esteban G, Chioua M, Nikolic K, Agbaba D, Moraleda I, Iriepa I, Soriano E, Samadi A, Unzeta M, Marco-Contelles J

Drug Design, Development and Therapy 2014, 8:1893-1910

Published Date: 13 October 2014

Synthesis and biological evaluation of novel indole-2-one and 7-aza-2-oxindole derivatives as anti-inflammatory agents

Chen G, Jiang L, Dong L, Wang Z, Xu F, Ding T, Fu L, Fang Q, Liu Z, Shan X, Liang G

Drug Design, Development and Therapy 2014, 8:1869-1892

Published Date: 13 October 2014

Preclinical profile of cabazitaxel

Vrignaud P, Semiond D, Benning V, Beys E, Bouchard H, Gupta S

Drug Design, Development and Therapy 2014, 8:1851-1867

Published Date: 13 October 2014

Potent tumor targeting drug release system comprising MMP-2 specific peptide fragment with self-assembling characteristics

Hua D, Kong W, Zheng X, Zhou Z, Yu B, Li Y, Wang Y, Yang X, Liu C, Tang L, Li Y, Gong M

Drug Design, Development and Therapy 2014, 8:1839-1849

Published Date: 14 October 2014

Effects of an oral allosteric AKT inhibitor (MK-2206) on human nasopharyngeal cancer in vitro and in vivo

Zhao YY, Tian Y, Zhang J, Xu F, Yang YP, Huang Y, Zhao HY, Zhang JW, Xue C, Lam MH, Yan L, Hu ZH, Dinglin XX, Zhang L

Drug Design, Development and Therapy 2014, 8:1827-1837

Published Date: 10 October 2014

Development of polyether urethane intravaginal rings for the sustained delivery of hydroxychloroquine

Chen Y, Traore YL, Li A, Fowke KR, Ho EA

Drug Design, Development and Therapy 2014, 8:1801-1815

Published Date: 9 October 2014

Purification and in vitro antioxidant activities of tellurium-containing phycobiliproteins from tellurium-enriched Spirulina platensis

Yang F, Wong KH, Yang YF, Li XL, Jiang J, Zheng WJ, Wu HL, Chen TF

Drug Design, Development and Therapy 2014, 8:1789-1800

Published Date: 9 October 2014

(R)-(+)-α-Lipoic acid protected NG108-15 cells against H2O2-induced cell death through PI3K-Akt/GSK-3β pathway and suppression of NF-κβ-cytokines

Kamarudin MNA, Mohd Raflee NA, Syed Hussein SS, Lo JY, Supriady H, Abdul Kadir H

Drug Design, Development and Therapy 2014, 8:1765-1780

Published Date: 8 October 2014

Inhaled tyrosine kinase inhibitors for pulmonary hypertension: a possible future treatment

Pitsiou G, Zarogoulidis P, Petridis D, Kioumis I, Lampaki S, Organtzis J, Porpodis K, Papaiwannou A, Tsiouda T, Hohenforst-Schmidt W, Kakolyris S, Syrigos K, Huang H, Li Q, Turner JF, Zarogoulidis K

Drug Design, Development and Therapy 2014, 8:1753-1763

Published Date: 7 October 2014

Effect of renal function on the pharmacokinetics of fimasartan: a single-dose, open-label, Phase I study

Kim S, Lee J, Shin D, Lim KS, Kim YS, Jang IJ, Yu KS

Drug Design, Development and Therapy 2014, 8:1723-1731

Published Date: 6 October 2014

Multiple-dose pharmacokinetics and pharmacodynamics of evogliptin (DA-1229), a novel dipeptidyl peptidase IV inhibitor, in healthy volunteers

Gu N, Park MK, Kim TE, Bahng MY, Lim KS, Cho SH, Yoon SH, Cho JY, Jang IJ, Yu KS

Drug Design, Development and Therapy 2014, 8:1709-1721

Published Date: 6 October 2014

Effects of immunosuppressive treatment on protein expression in rat kidney

Kędzierska K, Sporniak-Tutak K, Sindrewicz K, Bober J, Domański L, Parafiniuk M, Urasińska E, Ciechanowicz A, Domański M, Smektała T, Masiuk M, Skrzypczak W, Ożgo M, Kabat-Koperska J, Ciechanowski K,

Drug Design, Development and Therapy 2014, 8:1695-1708

Published Date: 30 September 2014

Exploratory meta-analysis on lisdexamfetamine versus placebo in adult ADHD

Maneeton N, Maneeton B, Suttajit S, Reungyos J, Srisurapanont M, Martin SD

Drug Design, Development and Therapy 2014, 8:1685-1693

Published Date: 3 October 2014

An optimized probucol microencapsulated formulation integrating a secondary bile acid (deoxycholic acid) as a permeation enhancer

Mooranian A, Negrulj R, Chen-Tan N, Watts GF, Arfuso F, Al-Salami H

Drug Design, Development and Therapy 2014, 8:1673-1683

Published Date: 29 September 2014

Anticancer, antioxidant activities, and DNA affinity of novel monocationic bithiophenes and analogues

Ismail MA, Arafa RK, Yousssef MM, El-Sayed WM

Drug Design, Development and Therapy 2014, 8:1659-1672

Published Date: 29 September 2014

α-Mangostin from Cratoxylum arborescens demonstrates apoptogenesis in MCF-7 with regulation of NF-κB and Hsp70 protein modulation in vitro, and tumor reduction in vivo

Ibrahim MY, Hashim NM, Mohan S, Abdulla MA, Kamalidehghan B, Ghaderian M, Dehghan F, Ali LZ, Arbab IA, Yahayu M, Lian GE, Ahmadipour F, Ali HM

Drug Design, Development and Therapy 2014, 8:1629-1647

Published Date: 27 September 2014

Buccal acetaminophen provides fast analgesia: two randomized clinical trials in healthy volunteers

Pickering G, Macian N, Libert F, Cardot JM, Coissard S, Perovitch P, Maury M, Dubray C

Drug Design, Development and Therapy 2014, 8:1621-1627

Published Date: 26 September 2014

Pharmacokinetics and tolerability of the new second-generation nonnucleoside reverse- transcriptase inhibitor KM-023 in healthy subjects

Cha YJ, Lim KS, Park MK, Schneider S, Bray B, Kang MC, Chung JY, Yoon SH, Cho JY, Yu KS

Drug Design, Development and Therapy 2014, 8:1613-1619

Published Date: 26 September 2014

Bioactive protein fraction DLBS1033 containing lumbrokinase isolated from Lumbricus rubellus: ex vivo, in vivo, and pharmaceutic studies

Tjandrawinata RR, Trisina J, Rahayu P, Prasetya LA, Hanafiah A, Rachmawati H

Drug Design, Development and Therapy 2014, 8:1585-1593

Published Date: 25 September 2014

Provisional in-silico biopharmaceutics classification (BCS) to guide oral drug product development

Wolk O, Agbaria R, Dahan A

Drug Design, Development and Therapy 2014, 8:1563-1575

Published Date: 24 September 2014

Interferon-γ and celecoxib inhibit lung-tumor growth through modulating M2/M1 macrophage ratio in the tumor microenvironment

Ren F, Fan M, Mei J, Wu Y, Liu C, Pu Q, You Z, Liu L

Drug Design, Development and Therapy 2014, 8:1527-1538

Published Date: 23 September 2014

Synthesis and antibacterial activities of acylide derivatives bearing an aryl-tetrazolyl chain

Shan LX, Sun PH, Guo BQ, Xu XJ, Li ZQ, Sun JZ, Zhou SF, Chen WM

Drug Design, Development and Therapy 2014, 8:1515-1525

Published Date: 24 September 2014

Drug-likeness approach of 2-aminopyrimidines as histamine H3 receptor ligands

Sadek B, Schreeb A, Schwed JS, Weizel L, Stark H

Drug Design, Development and Therapy 2014, 8:1499-1513

Published Date: 19 September 2014

Ferulago angulata activates intrinsic pathway of apoptosis in MCF-7 cells associated with G1 cell cycle arrest via involvement of p21/p27

Karimian H, Moghadamtousi SZ, Fadaeinasab M, Golbabapour S, Razavi M, Hajrezaie M, Arya A, Abdulla MA, Mohan S, Ali HM, Noordin MI

Drug Design, Development and Therapy 2014, 8:1481-1497

Published Date: 22 September 2014

Enhanced bioavailability and anthelmintic efficacy of mebendazole in redispersible microparticles with low-substituted hydroxypropylcellulose

Torre-Iglesias PM, García-Rodriguez JJ, Torrado G, Torrado S, Torrado-Santiago S, Bolás-Fernández F

Drug Design, Development and Therapy 2014, 8:1467-1479

Published Date: 18 September 2014

Pemphigus erythematosus relapse associated with atorvastatin intake

Lo Schiavo A, Puca RV, Romano F, Cozzi R

Drug Design, Development and Therapy 2014, 8:1463-1465

Published Date: 18 September 2014

Defensive mechanism in cholangiocarcinoma cells against oxidative stress induced by chlorin e6-based photodynamic therapy

Lee HM, Chung CW, Kim CH, Kim DH, Kwak TW, Jeong YI, Kang DH

Drug Design, Development and Therapy 2014, 8:1451-1462

Published Date: 18 September 2014

Inhibition of urokinase plasminogen activator “uPA” activity alters ethanol consumption and conditioned place preference in mice

Al Maamari E, Al Ameri M, Al Mansouri S, Bahi A

Drug Design, Development and Therapy 2014, 8:1391-1403

Published Date: 16 September 2014

Aminaphtone in the control of gingival bleeding in children

Pereira de Godoy JM, Macedo Paizan ML

Drug Design, Development and Therapy 2014, 8:1331-1334

Published Date: 10 September 2014

Novel swellable polymer of orchidaceae family for gastroretentive drug delivery of famotidine

Razavi M, Nyamathulla S, Karimian H, Noordin MI

Drug Design, Development and Therapy 2014, 8:1315-1329

Published Date: 9 September 2014

Superior rejection profile during the first 24 months after heart transplantation under tacrolimus as baseline immunosuppressive regimen

Helmschrott M, Beckendorf J, Akyol C, Ruhparwar A, Schmack B, Erbel C, Gleissner CA, Akhavanpoor M, Ehlermann P, Bruckner T, Katus HA, Doesch AO

Drug Design, Development and Therapy 2014, 8:1307-1314

Published Date: 9 September 2014

Efficacy and safety of immunosuppressive therapy in the treatment of seronegative hepatitis associated aplastic anemia

Chen HF, Xu BX, Shen HS, Li ZY, Jin LJ, Tang JQ, Wang J, Zhu JJ, Qin LM, Cui QY, Ren YY, Wu TQ

Drug Design, Development and Therapy 2014, 8:1299-1305

Published Date: 9 September 2014

Hydrogen sulfide, a potential novel drug, attenuates concanavalin A-induced hepatitis

Cheng P, Chen K, Xia Y, Dai WQ, Wang F, Shen M, Wang C, Yang J, Zhu R, Zhang H, Li JJ, Zheng Y, Wang J, Zhang Y, Lu J, Zhou YQ, Guo CY

Drug Design, Development and Therapy 2014, 8:1277-1286

Published Date: 9 September 2014

Update on the clinical utility and practical use of ropivacaine in Chinese patients

Li M, Wan L, Mei W, Tian Y

Drug Design, Development and Therapy 2014, 8:1269-1276

Published Date: 9 September 2014

N-n-butyl haloperidol iodide inhibits H2O2- induced Na+/Ca2+-exchanger activation via the Na+/H+ exchanger in rat ventricular myocytes

Huang YP, Gao FF, Wang B, Zheng FC, Zhang YM, Chen YC, Huang ZQ, Zheng YS, Zhong SP, Shi GG

Drug Design, Development and Therapy 2014, 8:1257-1267

Published Date: 9 September 2014

Single dose pharmacokinetic equivalence study of two gabapentin preparations in healthy subjects

Tjandrawinata RR, Setiawati E, Putri RSI, Yunaidi DA, Amalia F, Susanto LW

Drug Design, Development and Therapy 2014, 8:1249-1255

Published Date: 4 September 2014

Transient hypofibrinogenemia due to allopurinol

Yin ZQ, Xu JL, Li YQ, Xia JP, Luo D

Drug Design, Development and Therapy 2014, 8:1231-1233

Published Date: 2 September 2014

Microencapsulation as a novel delivery method for the potential antidiabetic drug, Probucol

Mooranian A, Negrulj R, Chen-Tan N, Al-Sallami HS, Fang Z, Mukkur TK, Mikov M, Golocorbin-Kon S, Fakhoury M, Watts GF, Matthews V, Arfuso F, Al-Salami H

Drug Design, Development and Therapy 2014, 8:1221-1230

Published Date: 9 September 2014

Combination therapy with sivelestat and recombinant human soluble thrombomodulin for ARDS and DIC patients

Miyoshi S, Ito R, Katayama H, Dote K, Aibiki M, Hamada H, Okura T, Higaki J

Drug Design, Development and Therapy 2014, 8:1211-1219

Published Date: 2 September 2014

Remote ischemic conditioning improves coronary microcirculation in healthy subjects and patients with heart failure

Kono Y, Fukuda S, Hanatani A, Nakanishi K, Otsuka K, Taguchi H, Shimada K

Drug Design, Development and Therapy 2014, 8:1175-1181

Published Date: 27 August 2014

The efficacy of ampicillin and Lactobacillus casei rhamnosus in the active management of preterm premature rupture of membranes remote from term

Kavak SB, Kavak E, Ilhan R, Atilgan R, Arat O, Deveci U, Sapmaz E

Drug Design, Development and Therapy 2014, 8:1169-1173

Published Date: 30 August 2014

Effect of administration of water enriched in O2 by injection or electrolysis on transcutaneous oxygen pressure in anesthetized pigs

Charton A, Péronnet F, Doutreleau S, Lonsdorfer E, Klein A, Jimenez L, Geny B, Diemunsch P, Richard R

Drug Design, Development and Therapy 2014, 8:1161-1167

Published Date: 26 August 2014

Downregulated microRNA-148b in circulating PBMCs in chronic myeloid leukemia patients with undetectable minimal residual disease: a possible biomarker to discontinue imatinib safely

Ohyashiki JH, Ohtsuki K, Mizoguchi I, Yoshimoto T, Katagiri S, Umezu T, Ohyashiki K

Drug Design, Development and Therapy 2014, 8:1151-1159

Published Date: 25 August 2014

Nasal saline as a placebo in a rhinosinusitis study

Karadag A, Catal F

Drug Design, Development and Therapy 2014, 8:1135-1137

Published Date: 20 August 2014

Comparison of effects of anti-angiogenic agents in the zebrafish efficacy–toxicity model for translational anti-angiogenic drug discovery

Chimote G, Sreenivasan J, Pawar N, Subramanian J, Sivaramakrishnan H, Sharma S

Drug Design, Development and Therapy 2014, 8:1107-1123

Published Date: 19 August 2014

Predictive performance of gentamicin dosing nomograms

Lee J, Yoon S, Shin D, Han H, An H, Lee J, Lim KS, Yu KS, Lee H

Drug Design, Development and Therapy 2014, 8:1097-1106

Published Date: 16 August 2014

Investigation of aromatase inhibitory activity of metal complexes of 8-hydroxyquinoline and uracil derivatives

Prachayasittikul V, Pingaew R, Nantasenamat C, Prachayasittikul S, Ruchirawat S, Prachayasittikul V

Drug Design, Development and Therapy 2014, 8:1089-1096

Published Date: 14 August 2014

Safety and efficacy of S-1 chemotherapy in recurrent and metastatic nasopharyngeal carcinoma patients after failure of platinum-based chemotherapy: multi-institutional retrospective analysis

Peng PJ, Cheng H, Ou XQ, Zeng LJ, Wu X, Liu YM, Lin Z, Tang YN, Wang SY, Zhang HY, Chen ZB

Drug Design, Development and Therapy 2014, 8:1083-1087

Published Date: 14 August 2014

Optimization of nebulized delivery of linezolid, daptomycin, and vancomycin aerosol

Zarogoulidis P, Kioumis I, Lampaki S, Organtzis J, Porpodis K, Spyratos D, Pitsiou G, Petridis D, Pataka A, Huang H, Li Q, Yarmus L, Hohenforst-Schmidt W, Pezirkianidis N, Zarogoulidis K

Drug Design, Development and Therapy 2014, 8:1065-1072

Published Date: 12 August 2014

Design, synthesis, and anticancer activity of novel berberine derivatives prepared via CuAAC “click” chemistry as potential anticancer agents

Jin X, Yan TH, Yan L, Li Q, Wang RL, Hu ZL, Jiang YY, Sun QY, Cao YB

Drug Design, Development and Therapy 2014, 8:1047-1059

Published Date: 6 August 2014

Antimycobacterial, antimicrobial, and biocompatibility properties of para-aminosalicylic acid with zinc layered hydroxide and Zn/Al layered double hydroxide nanocomposites

Saifullah B, El Zowalaty ME, Arulselvan P, Fakurazi S, Webster TJ, Geilich BM, Hussein MZ

Drug Design, Development and Therapy 2014, 8:1029-1036

Published Date: 28 July 2014

Novel artificial cell microencapsulation of a complex gliclazide-deoxycholic bile acid formulation: a characterization study

Mooranian A, Negrulj R, Chen-Tan N, Al-Sallami HS, Fang Z, Mukkur T, Mikov M, Golocorbin-Kon S, Fakhoury M, Arfuso F, Al-Salami H

Drug Design, Development and Therapy 2014, 8:1003-1012

Published Date: 28 July 2014

Carbonic anhydrase IX-directed immunoliposomes for targeted drug delivery to human lung cancer cells in vitro

Wong BCK, Zhang H, Qin L, Chen H, Fang C, Lu A, Yang Z

Drug Design, Development and Therapy 2014, 8:993-1001

Published Date: 22 July 2014

Sulforaphane reverses glucocorticoid-induced apoptosis in osteoblastic cells through regulation of the Nrf2 pathway

Lin H, Wei B, Li GS, Zheng JC, Sun JC, Chu JQ, Zeng R, Niu YR

Drug Design, Development and Therapy 2014, 8:973-982

Published Date: 19 July 2014

Evaluation of the biological activity of novel monocationic fluoroaryl-2,2’-bichalcophenes and their analogues

Hussin WA, Ismail MA, Alzahrani AM, El-Sayed WM

Drug Design, Development and Therapy 2014, 8:963-972

Published Date: 17 July 2014

Pustular drug eruption due to Panax notoginseng saponins

Yin ZQ, Ma LW, Xu JL, Xia JP, Luo D

Drug Design, Development and Therapy 2014, 8:957-961

Published Date: 16 July 2014

The load and release characteristics on a strong cationic ion-exchange fiber: kinetics, thermodynamics, and influences

Yuan J, Gao Y, Wang X, Liu H, Che X, Xu L, Yang Y, Wang Q, Wang Y, Li S

Drug Design, Development and Therapy 2014, 8:945-955

Published Date: 16 July 2014

Prostatic urethral angle might be a predictor of treatment efficacy of α-blockers in men with lower urinary tract symptoms

Hou CP, Chen CL, Lin YH, Tsai YL, Chang PL, Juang HH, Tsui KH

Drug Design, Development and Therapy 2014, 8:937-943

Published Date: 15 July 2014

Design of oral agents for the management of multiple sclerosis: benefit and risk assessment for dimethyl fumarate

Nicholas JA, Boster AL, Imitola J, O'Connell C, Racke MK

Drug Design, Development and Therapy 2014, 8:897-908

Published Date: 7 July 2014

Virologic breakthrough in a patient with chronic hepatitis B by combination treatment with tenofovir disoproxil fumarate and entecavir

Suzuki F, Sezaki H, Akuta N, Suzuki Y, Kawamura Y, Hosaka T, Kobayashi M, Saitoh S, Arase Y, Ikeda K, Kobayashi M, Watahiki S, Mineta R, Suzuki Y, Kumada H

Drug Design, Development and Therapy 2014, 8:869-873

Published Date: 30 June 2014

Novel nanocrystal formulation of megestrol acetate has improved bioavailability compared with the conventional micronized formulation in the fasting state

Jang K, Yoon S, Kim SE, Cho JY, Yoon SH, Lim KS, Yu KS, Jang IJ, Lee H

Drug Design, Development and Therapy 2014, 8:851-858

Published Date: 25 June 2014

Quetiapine for acute bipolar depression: a systematic review and meta-analysis

Suttajit S, Srisurapanont M, Maneeton N, Maneeton B

Drug Design, Development and Therapy 2014, 8:827-838

Published Date: 25 June 2014

Design of a new therapy to treat snake envenomation

Shahidi Bonjar L

Drug Design, Development and Therapy 2014, 8:819-825

Published Date: 18 June 2014

Use of metformin and vildagliptin for treatment of type 2 diabetes in the elderly

Sicras-Mainar A, Navarro-Artieda R

Drug Design, Development and Therapy 2014, 8:811-818

Published Date: 18 June 2014

Thrombolytic treatment (alteplase; rt-PA) in acute massive pulmonary embolism and cardiopulmonary arrest

Dirican A, Ozkaya S, Atas AE, Ulu EK, Kitapci I, Ece F

Drug Design, Development and Therapy 2014, 8:759-763

Published Date: 12 June 2014

The new concepts on overcoming drug resistance in lung cancer

Zhang W, Lei P, Dong X, Xu C

Drug Design, Development and Therapy 2014, 8:735-744

Published Date: 6 June 2014

Evaluation of cytotoxic and chemotherapeutic properties of boldine in breast cancer using in vitro and in vivo models

Paydar M, Kamalidehghan B, Wong YL, Wong WF, Looi CY, Mustafa MR

Drug Design, Development and Therapy 2014, 8:719-733

Published Date: 6 June 2014

Ivabradine, coronary artery disease, and heart failure: beyond rhythm control

Scicchitano P, Cortese F, Ricci G, Carbonara S, Moncelli M, Iacoviello M, Cecere A, Gesualdo M, Zito A, Caldarola P, Scrutinio D, Lagioia R, Riccioni G, Ciccone MM

Drug Design, Development and Therapy 2014, 8:689-700

Published Date: 3 June 2014

Evaluation of ceftiofur–PHBV microparticles in rats

Vilos C, Constandil L, Rodas PI, Cantin M, Zepeda K, Herrera N, Velasquez LA

Drug Design, Development and Therapy 2014, 8:651-666

Published Date: 29 May 2014

Neurotherapeutic activity of the recombinant heat shock protein Hsp70 in a model of focal cerebral ischemia in rats

Shevtsov MA, Nikolaev BP, Yakovleva LY, Dobrodumov AV, Dayneko AS, Shmonin AA, Vlasov TD, Melnikova EV, Vilisov AD, Guzhova IV, Ischenko AM, Mikhrina AL, Galibin OV, Yakovenko IV, Margulis BA

Drug Design, Development and Therapy 2014, 8:639-650

Published Date: 28 May 2014

Is increasing the dose of Entecavir effective in partial virological responders?

Erturk A, Adnan Akdogan R, Parlak E, Cure E, Cumhur Cure M, Ozturk C

Drug Design, Development and Therapy 2014, 8:621-625

Published Date: 29 May 2014

Quinoxaline-substituted chalcones as new inhibitors of breast cancer resistance protein ABCG2: polyspecificity at B-ring position

Winter E, Gozzi GJ, Chiaradia-Delatorre LD, Daflon-Yunes N, Terreux R, Gauthier C, Mascarello A, Leal PC, Cadena SM, Yunes RA, Nunes RJ, Creczynski-Pasa TB, Di Pietro A

Drug Design, Development and Therapy 2014, 8:609-619

Published Date: 27 May 2014

Profile of gantenerumab and its potential in the treatment of Alzheimer’s disease [Corrigendum]

Novakovic D, Feligioni M, Scaccianoce S, Caruso A, Piccinin S, Schepisi C, Errico F, Mercuri NB, Nicoletti F, Nisticò R

Drug Design, Development and Therapy 2014, 8:569-570

Published Date: 21 May 2014

Molecular pharmacodynamics of new oral drugs used in the treatment of multiple sclerosis

di Nuzzo L, Orlando R, Nasca C, Nicoletti F

Drug Design, Development and Therapy 2014, 8:555-568

Published Date: 19 May 2014

Protective effect of picroside II on myocardial ischemia reperfusion injury in rats

Wu N, Li W, Shu W, Jia D

Drug Design, Development and Therapy 2014, 8:545-554

Published Date: 14 May 2014

Effect of MMX® mesalamine coadministration on the pharmacokinetics of amoxicillin, ciprofloxacin XR, metronidazole, and sulfamethoxazole: results from four randomized clinical trials

Pierce D, Corcoran M, Martin P, Barrett K, Inglis S, Preston P, Thompson TN, Willsie SK

Drug Design, Development and Therapy 2014, 8:529-543

Published Date: 14 May 2014

The effects of sulodexide on both clinical and molecular parameters in patients with mixed arterial and venous ulcers of lower limbs

Serra R, Gallelli L, Conti A, De Caridi G, Massara M, Spinelli F, Buffone G, Caliò FG, Amato B, Ceglia S, Spaziano G, Scaramuzzino L, Ferrarese AG, Grande R, de Franciscis S

Drug Design, Development and Therapy 2014, 8:519-527

Published Date: 13 May 2014

Synthesis, antimicrobial, and anti-inflammatory activity, of novel S-substituted and N-substituted 5-(1-adamantyl)-1,2,4-triazole-3-thiols

Al-Abdullah ES, Asiri HH, Lahsasni S, Habib EE, Ibrahim TM, El-Emam AA

Drug Design, Development and Therapy 2014, 8:505-518

Published Date: 12 May 2014

Identification of a novel potential antitumor activity of gossypol as an APE1/Ref-1 inhibitor

Qian CY, Li MX, Sui JD, Ren T, Li Z, Zhang L, Zhou LW, Cheng Y, Wang D

Drug Design, Development and Therapy 2014, 8:485-496

Published Date: 9 May 2014

P-glycoprotein- and organic anion-transporting polypeptide-mediated transport of periplocin may lead to drug–herb/drug–drug interactions

Liang S, Deng FC, Xing HY, Wen H, Shi XY, Martey ON, Koomson E, He X

Drug Design, Development and Therapy 2014, 8:475-483

Published Date: 9 May 2014

Improving anticancer efficacy of (-)-epigallocatechin-3-gallate gold nanoparticles in murine B16F10 melanoma cells

Chen CC, Hsieh DS, Huang KJ, Chan YL, Hong PD, Yeh MK, Wu CJ

Drug Design, Development and Therapy 2014, 8:459-474

Published Date: 8 May 2014

Inhibition of B7-1 (CD80) by RhuDex® reduces lipopolysaccharide-mediated inflammation in human atherosclerotic lesions

Doesch AO, Zhao L, Gleissner CA, Akhavanpoor M, Rohde D, Okuyucu D, Hakimi M, Dengler TJ, Katus HA, Erbel C

Drug Design, Development and Therapy 2014, 8:447-457

Published Date: 12 May 2014

Linagliptin: from bench to bedside

Doupis J

Drug Design, Development and Therapy 2014, 8:431-446

Published Date: 5 May 2014

Topical infliximab for the suppression of wound healing following experimental glaucoma filtration surgery

Turgut B, Eren K, Akın MM, Demir T, Kobat S

Drug Design, Development and Therapy 2014, 8:421-429

Published Date: 2 May 2014

Combined isosorbide dinitrate and ibuprofen as a novel therapy for muscular dystrophies: evidence from Phase I studies in healthy volunteers

Cossu MV, Cattaneo D, Fucile S, Pellegrino P, Baldelli S, Cozzi V, Capetti A, Clementi E

Drug Design, Development and Therapy 2014, 8:411-419

Published Date: 2 May 2014

Formulation development for the orexin receptor antagonist almorexant: assessment in two clinical studies

Dingemanse J, Gehin M, Cruz HG, Hoever P

Drug Design, Development and Therapy 2014, 8:397-403

Published Date: 28 April 2014

Triazole derivatives with improved in vitro antifungal activity over azole drugs

Yu S, Chai X, Wang Y, Cao Y, Zhang J, Wu Q, Zhang D, Jiang Y, Yan T, Sun Q

Drug Design, Development and Therapy 2014, 8:383-390

Published Date: 10 April 2014

Discovery and evaluation of asymmetrical monocarbonyl analogs of curcumin as anti-inflammatory agents

Zhang Y, Zhao C, He W, Wang Z, Fang Q, Xiao B, Liu Z, Liang G, Yang S

Drug Design, Development and Therapy 2014, 8:373-382

Published Date: 4 April 2014

Tocilizumab in the treatment of rheumatoid arthritis and beyond

Shetty A, Hanson R, Korsten P, Shawagfeh M, Arami S, Volkov S, Vila O, Swedler W, Shunaigat AN, Smadi S, Sawaqed R, Perkins D, Shahrara S, Sweiss NJ

Drug Design, Development and Therapy 2014, 8:349-364

Published Date: 28 March 2014

Anti-TNF therapy for juvenile idiopathic arthritis-related uveitis

Semeraro F, Arcidiacono B, Nascimbeni G, Angi M, Parolini B, Costagliola C

Drug Design, Development and Therapy 2014, 8:341-348

Published Date: 24 March 2014

Tetrandrine protects mouse retinal ganglion cells from ischemic injury

Li WY, Yang C, Lu J, Huang P, Barnstable CJ, Zhang C, Zhang SS

Drug Design, Development and Therapy 2014, 8:327-339

Published Date: 21 March 2014

Differential microRNA expression signatures and cell type-specific association with Taxol resistance in ovarian cancer cells

Kim YW, Kim EY, Jeon D, Liu JL, Kim H, Choi JW, Ahn WS

Drug Design, Development and Therapy 2014, 8:293-314

Published Date: 24 February 2014

Ulipristal acetate: a novel pharmacological approach for the treatment of uterine fibroids

Biglia N, Carinelli S, Maiorana A, D'Alonzo M, Lo Monte G, Marci R

Drug Design, Development and Therapy 2014, 8:285-292

Published Date: 20 February 2014

Paclitaxel: new uses for an old drug

Zhang D, Yang R, Wang S, Dong Z

Drug Design, Development and Therapy 2014, 8:279-284

Published Date: 20 February 2014

Combining rimonabant and fentanyl in a single entity: preparation and pharmacological results

Fernández-Fernández C, Callado LF, Girón R, Sánchez E, Erdozain AM, López-Moreno JA, Morales P, Rodríguez de Fonseca F, Fernández-Ruiz J, Goya P, Meana JJ, Martín MI, Jagerovic N

Drug Design, Development and Therapy 2014, 8:263-277

Published Date: 20 February 2014

Insulin induces drug resistance in melanoma through activation of the PI3K/Akt pathway

Chi M, Ye Y, Zhang XD, Chen J

Drug Design, Development and Therapy 2014, 8:255-262

Published Date: 17 February 2014

Efficacy and safety of febuxostat in the treatment of hyperuricemia in stable kidney transplant recipients

Sofue T, Inui M, Hara T, Nishijima Y, Moriwaki K, Hayashida Y, Ueda N, Nishiyama A, Kakehi Y, Kohno M

Drug Design, Development and Therapy 2014, 8:245-253

Published Date: 17 February 2014

Effect of vildagliptin add-on treatment to metformin on plasma asymmetric dimethylarginine in type 2 diabetes mellitus patients

Cakirca M, Karatoprak C, Zorlu M, Kiskac M, Kanat M, Cikrikcioglu MA, Soysal P, Hursitoglu M, Camli AA, Erkoc R, Abdul-Ghani M

Drug Design, Development and Therapy 2014, 8:239-243

Published Date: 14 February 2014

Characterization of renal biomarkers for use in clinical trials: biomarker evaluation in healthy volunteers

Brott DA, Adler SH, Arani R, Lovick SC, Pinches M, Furlong ST

Drug Design, Development and Therapy 2014, 8:227-237

Published Date: 13 February 2014

Sinonasal inhalation of tobramycin vibrating aerosol in cystic fibrosis patients with upper airway Pseudomonas aeruginosa colonization: results of a randomized, double-blind, placebo-controlled pilot study

Mainz JG, Schädlich K, Schien C, Michl R, Schelhorn-Neise P, Koitschev A, Koitschev C, Keller PM, Riethmüller J, Wiedemann B, Beck JF

Drug Design, Development and Therapy 2014, 8:209-217

Published Date: 10 February 2014

Omalizumab, an anti-immunoglobulin E antibody: state of the art

Incorvaia C, Mauro M, Russello M, Formigoni C, Riario-Sforza GG, Ridolo E

Drug Design, Development and Therapy 2014, 8:197-207

Published Date: 7 February 2014

Novel N-substituted aminobenzamide scaffold derivatives targeting the dipeptidyl peptidase-IV enzyme

Al-Balas QA, Sowaileh MF, Hassan MA, Qandil AM, Alzoubi KH, Mhaidat NM, Almaaytah AM, Khabour OF

Drug Design, Development and Therapy 2014, 8:129-163

Published Date: 16 January 2014

Clinical experimentation with aerosol antibiotics: current and future methods of administration [Corrigendum]

Zarogoulidis P, Kioumis I, Porpodis K, Spyratos D, Tsakiridis K, Huang H, Li Q, Turner JF, Browning R, Hohenforst-Schmidt W, Zarogoulidis K

Drug Design, Development and Therapy 2014, 8:121-122

Published Date: 16 January 2014

Transdermal testosterone replacement therapy in men

Ullah MI, Riche DM, Koch CA

Drug Design, Development and Therapy 2014, 8:101-112

Published Date: 9 January 2014

(+)-Grandifloracin, an antiausterity agent, induces autophagic PANC-1 pancreatic cancer cell death

Ueda JY, Athikomkulchai S, Miyatake R, Saiki I, Esumi H, Awale S

Drug Design, Development and Therapy 2014, 8:39-47

Published Date: 18 December 2013

Lixisenatide as add-on therapy to basal insulin

Brown DX, Butler EL, Evans M

Drug Design, Development and Therapy 2014, 8:25-38

Published Date: 13 December 2013