Menu
Back to Journals » Drug Design, Development and Therapy » Volume 8
Drug Design, Development and Therapy
ISSN: 1177-8881
- View all (3978)
- Volume 17, 2023 (222)
- Volume 16, 2022 (316)
- Volume 15, 2021 (399)
- Volume 14, 2020 (477)
- Volume 13, 2019 (387)
- Volume 12, 2018 (382)
- Volume 11, 2017 (330)
- Volume 10, 2016 (374)
- Volume 9, 2015 (543)
- Volume 8, 2014 (231)
- Volume 7, 2013 (143)
- Volume 6, 2012 (42)
- Volume 5, 2011 (40)
- Volume 4, 2010 (35)
- Volume 3, 2009 (27)
- Volume 2, 2008 (29)
- Volume 1, 2007 (1)
Archive: Volume 8, 2014
Xyloketal B, a marine compound, acts on a network of molecular proteins and regulates the activity and expression of rat cytochrome P450 3a: a bioinformatic and animal study
Su JH, Chang C, Xiang Q, Zhou ZW, Luo R, Yang L, He ZX, Yang HT, Li J, Bei Y, Xu JM, Zhang MJ, Zhang QH, Su ZJ, Huang YD, Pang JY, Zhou SF
Drug Design, Development and Therapy 2014, 8:2555-2602
Published Date: 12 December 2014
Curative treatment can be an option for patients with metastatic squamous cell cancer of the head and neck
Guenne C, Fayette J, Cosmidis A, Fuchsmann C, Tartas S, Favrel V, Céruse P
Drug Design, Development and Therapy 2014, 8:2549-2553
Published Date: 12 December 2014
Stevens–Johnson Syndrome and toxic epidermalnecrolysis: a multi-aspect comparative 7-year study from the People’s Republic of China
Sun J, Liu J, Gong QL, Ding GZ, Ma LW, Zhang LC, Lu Y
Drug Design, Development and Therapy 2014, 8:2539-2547
Published Date: 12 December 2014
Treatment of port wine stains with pulsed dye laser: a retrospective study of 848 cases in Shandong Province, People’s Republic of China
Shi W, Wang J, Lin Y, Geng J, Wang H, Gong Y, Liu H, Zhang F
Drug Design, Development and Therapy 2014, 8:2531-2538
Published Date: 12 December 2014
Sequential treatment with AT-101 enhances cisplatin chemosensitivity in human non-small cell lung cancer cells through inhibition of apurinic/apyrimidinic endonuclease 1-activated IL-6/STAT3 signaling pathway
Ren T, Shan J, Qing Y, Qian C, Li Q, Lu G, Li M, Li C, Peng Y, Luo H, Zhang S, Zhang W, Wang D, Zhou SF
Drug Design, Development and Therapy 2014, 8:2517-2529
Published Date: 12 December 2014
A new recombinant factor VIII: from genetics to clinical use
Santagostino E
Drug Design, Development and Therapy 2014, 8:2507-2515
Published Date: 12 December 2014
Dapagliflozin for the treatment of type 2 diabetes: a review of the literature
Saeed MA, Narendran P
Drug Design, Development and Therapy 2014, 8:2493-2505
Published Date: 10 December 2014
Optimizing iron delivery in the management of anemia: patient considerations and the role of ferric carboxymaltose
Toblli JE, Angerosa M
Drug Design, Development and Therapy 2014, 8:2475-2491
Published Date: 11 December 2014
Scientometrics of anesthetic drugs and their techniques of administration, 1984–2013
Vlassakov KV, Kissin I
Drug Design, Development and Therapy 2014, 8:2463-2473
Published Date: 9 December 2014
Mesenchymal stem cell-based NK4 gene therapy in nude mice bearing gastric cancer xenografts
Zhu Y, Cheng M, Yang Z, Zeng CY, Chen J, Xie Y, Luo SW, Zhang KH, Zhou SF, Lu NH
Drug Design, Development and Therapy 2014, 8:2449-2462
Published Date: 9 December 2014
Matrix-induced autologous chondrocyte implantation for the treatment of chondral defects of the knees in Chinese patients
Zhang ZW, Zhong X, Ji HR, Tang ZB, Bai JP, Yao MM, Hou JL, Zheng MH, Wood D, Sun JZ, Zhou SF, Liu AB
Drug Design, Development and Therapy 2014, 8:2439-2448
Published Date: 5 December 2014
Design real-time reversal of tumor multidrug resistance cleverly with shortened carbon nanotubes
Wu P, Li S, Zhang H
Drug Design, Development and Therapy 2014, 8:2431-2438
Published Date: 5 December 2014
Clinicopathological significance and potential drug target of RUNX3 in breast cancer
Yu YY, Chen C, Kong FF, Zhang W
Drug Design, Development and Therapy 2014, 8:2423-2430
Published Date: 5 December 2014
Functional characterization of a competitive peptide antagonist of p65 in human macrophage-like cells suggests therapeutic potential for chronic inflammation
Srinivasan M, Blackburn C, Lahiri DK
Drug Design, Development and Therapy 2014, 8:2409-2421
Published Date: 3 December 2014
Cisplatin-induced hyponatremia in malignancy: comparison between brand-name and generic formulation
Ochi N, Yamane H, Hotta K, Fujii H, Isozaki H, Honda Y, Yamagishi T, Kubo T, Tanimoto M, Kiura K, Takigawa N
Drug Design, Development and Therapy 2014, 8:2401-2408
Published Date: 3 December 2014
Drug development strategies for the treatment of obesity: how to ensure efficacy, safety, and sustainable weight loss
Barja-Fernandez S, Leis R, Casanueva FF, Seoane LM
Drug Design, Development and Therapy 2014, 8:2391-2400
Published Date: 1 December 2014
Discovery of potential drugs for human-infecting H7N9 virus containing R294K mutation
He JY, Li C, Wu G
Drug Design, Development and Therapy 2014, 8:2377-2390
Published Date: 1 December 2014
Scleral melt following Retisert intravitreal fluocinolone implant
Georgalas I, Koutsandrea C, Papaconstantinou D, Mpouritis D, Petrou P
Drug Design, Development and Therapy 2014, 8:2373-2375
Published Date: 28 November 2014
CCL19 and CCL21 modulate the inflammatory milieu in atherosclerotic lesions
Akhavanpoor M, Gleissner CA, Gorbatsch S, Doesch AO, Akhavanpoor H, Wangler S, Jahn F, Lasitschka F, Katus HA, Erbel C
Drug Design, Development and Therapy 2014, 8:2359-2371
Published Date: 27 November 2014
Interleukin 1 inhibition with anakinra in adult-onset Still disease: a meta-analysis of its efficacy and safety
Hong D, Yang Z, Han SY, Liang X, Ma K, Zhang X
Drug Design, Development and Therapy 2014, 8:2345-2357
Published Date: 25 November 2014
Characterization and in vitro studies of the anticancer effect of oxidized carbon nanotubes functionalized with betulinic acid
Tan JM, Karthivashan G, Arulselvan P, Fakurazi S, Hussein MZ
Drug Design, Development and Therapy 2014, 8:2333-2343
Published Date: 20 November 2014
Pilot Phase II study of mazindol in children with attention deficit/hyperactivity disorder
Konofal E, Zhao W, Laouénan C, Lecendreux M, Kaguelidou F, Benadjaoud L, Mentré F, Jacqz-Aigrain E
Drug Design, Development and Therapy 2014, 8:2321-2332
Published Date: 11 December 2014
Choosing preclinical study models of diabetic retinopathy: key problems for consideration
Mi XS, Yuan TF, Ding Y, Zhong JX, So KF
Drug Design, Development and Therapy 2014, 8:2311-2319
Published Date: 18 November 2014
Profile of epratuzumab and its potential in the treatment of systemic lupus erythematosus
Al Rayes H, Touma Z
Drug Design, Development and Therapy 2014, 8:2303-2310
Published Date: 17 November 2014
Leptin signaling molecular actions and drug target in hepatocellular carcinoma
Jiang N, Sun R, Sun Q
Drug Design, Development and Therapy 2014, 8:2295-2302
Published Date: 14 November 2014
Risk of diarrhea in patients with type 2 diabetes mellitus treated with sitagliptin: a meta-analysis of 30 randomized clinical trials
Zhao QW, Hong DS, Zheng DS, Xiao Y, Wu BH
Drug Design, Development and Therapy 2014, 8:2283-2294
Published Date: 11 November 2014
The role of health technology assessment bodies in shaping drug development
Ciani O, Jommi C
Drug Design, Development and Therapy 2014, 8:2273-2281
Published Date: 10 November 2014
Inhibition of cardiac Kv1.5 potassium current by the anesthetic midazolam: mode of action
Vonderlin N, Fischer F, Zitron E, Seyler C, Scherer D, Thomas D, Katus HA, Scholz EP
Drug Design, Development and Therapy 2014, 8:2263-2271
Published Date: 7 November 2014
Identification of novel multitargeted PPARα/γ/δ pan agonists by core hopping of rosiglitazone
Wang XJ, Zhang J, Wang SQ, Xu WR, Cheng XC, Wang RL
Drug Design, Development and Therapy 2014, 8:2255-2262
Published Date: 7 November 2014
Women taking the “blue pill” (sildenafil citrate): such a big deal?
Lo Monte G, Graziano A, Piva I, Marci R
Drug Design, Development and Therapy 2014, 8:2251-2254
Published Date: 7 November 2014
Early non-steady-state population pharmacokinetics of oral cyclosporine in renal transplant recipients
Baek H, Han S, Yim DS, Kim SJ, Lee SY, Jang HR, Lee JE, Kim DJ, Kim YG, Oh HY, Huh W
Drug Design, Development and Therapy 2014, 8:2241-2249
Published Date: 7 November 2014
Studies of selective TNF inhibitors in the treatment of brain injury from stroke and trauma: a review of the evidence to date
Tuttolomondo A, Pecoraro R, Pinto A
Drug Design, Development and Therapy 2014, 8:2221-2239
Published Date: 7 November 2014
Caval filters in intensive care: a retrospective study
Ferraro F, Di Gennaro TL, Torino A, Petruzzi J, d'Elia A, Fusco P, Marfella R, Lettieri B
Drug Design, Development and Therapy 2014, 8:2213-2219
Published Date: 6 November 2014
Involvement of NF-ΚB and HSP70 signaling pathways in the apoptosis of MDA-MB-231 cells induced by a prenylated xanthone compound, α-mangostin, from Cratoxylum arborescens
Ibrahim MY, Hashim NM, Mohan S, Abdulla MA, Abdelwahab SI, Kamalidehghan B, Ghaderian M, Dehghan F, Ali LZ, Karimian H, Yahayu M, Ee GCL, Farjam AS, Ali HM
Drug Design, Development and Therapy 2014, 8:2193-2211
Published Date: 6 November 2014
Clinical utility of apixaban in the prevention and treatment of venous thromboembolism: current evidence
Zalpour A, Oo TH
Drug Design, Development and Therapy 2014, 8:2181-2191
Published Date: 5 November 2014
The CB1 cannabinoid receptor agonist reduces L-DOPA-induced motor fluctuation and ERK1/2 phosphorylation in 6-OHDA-lesioned rats
Song L, Yang X, Ma Y, Wu N, Liu Z
Drug Design, Development and Therapy 2014, 8:2173-2180
Published Date: 4 November 2014
Discovery and evaluation of novel anti-inflammatory derivatives of natural bioactive curcumin
Zhang Y, Jiang X, Peng K, Chen C, Fu L, Wang Z, Feng J, Liu Z, Zhang H, Liang G, Pan Z
Drug Design, Development and Therapy 2014, 8:2161-2171
Published Date: 4 November 2014
Functional analysis of tanshinone IIA that blocks the redox function of human apurinic/apyrimidinic endonuclease 1/redox factor-1
Sui J, Li M, Qian C, Wang S, Cheng Y, Chen BP, Wang D
Drug Design, Development and Therapy 2014, 8:2147-2160
Published Date: 3 November 2014
Effect of honokiol on the induction of drug-metabolizing enzymes in human hepatocytes
Cho YY, Jeong HU, Kim JH, Lee HS
Drug Design, Development and Therapy 2014, 8:2137-2145
Published Date: 3 November 2014
Clinicopathological significance and potential drug target of p15INK4B in multiple myeloma
Li J, Bi L, Lin Y, Lu Z, Hou G
Drug Design, Development and Therapy 2014, 8:2129-2136
Published Date: 31 October 2014
Curcumin could reduce the monomer of TTR with Tyr114Cys mutation via autophagy in cell model of familial amyloid polyneuropathy
Li H, Zhang Y, Cao L, Xiong R, Zhang B, Wu L, Zhao Z, Chen SD
Drug Design, Development and Therapy 2014, 8:2121-2128
Published Date: 31 October 2014
The influence of goal-directed fluid therapy on the prognosis of elderly patients with hypertension and gastric cancer surgery
Zeng K, Li YZ, Liang M, Gao YG, Cai HD, Lin CZ
Drug Design, Development and Therapy 2014, 8:2113-2119
Published Date: 29 October 2014
Gastroprotective activity of Annona muricata leaves against ethanol-induced gastric injury in rats via Hsp70/Bax involvement
Moghadamtousi SZ, Rouhollahi E, Karimian H, Fadaeinasab M, Abdulla MA, Kadir HA
Drug Design, Development and Therapy 2014, 8:2099-2111
Published Date: 28 October 2014
The role of ketotifen in the prevention of testicular damage in rats with experimental unilateral undescended testes
Acikgoz A, Asci R, Aydin O, Çavuş H, Donmez G, Buyukalpelli R
Drug Design, Development and Therapy 2014, 8:2089-2097
Published Date: 23 October 2014
Bardoxolone methyl (CDDO-Me) as a therapeutic agent: an update on its pharmacokinetic and pharmacodynamic properties
Wang YY, Yang YX, Zhe H, He ZX, Zhou SF
Drug Design, Development and Therapy 2014, 8:2075-2088
Published Date: 23 October 2014
Effects of caffeic acid phenethyl ester on palatal mucosal defects and tooth extraction sockets
Günay A, Arpağ OF, Atilgan S, Yaman F, Atalay Y, Acikan I
Drug Design, Development and Therapy 2014, 8:2069-2074
Published Date: 23 October 2014
Clinical efficacy of second-generation tyrosine kinase inhibitors in imatinib-resistant gastrointestinal stromal tumors: a meta-analysis of recent clinical trials
Wu L, Zhang Z, Yao H, Liu K, Wen Y, Xiong L
Drug Design, Development and Therapy 2014, 8:2061-2067
Published Date: 30 October 2014
Ginger components as new leads for the design and development of novel multi-targeted anti-Alzheimer’s drugs: a computational investigation
Azam F, Amer AM, Abulifa AR, Elzwawi MM
Drug Design, Development and Therapy 2014, 8:2045-2059
Published Date: 23 October 2014
The doripenem serum concentrations in intensive care patients suffering from acute kidney injury, sepsis, and multi organ dysfunction syndrome undergoing continuous renal replacement therapy slow low-efficiency dialysis
Wieczorek A, Tokarz A, Gaszynski W, Gaszynski T
Drug Design, Development and Therapy 2014, 8:2039-2044
Published Date: 23 October 2014
Safety and efficacy of peramivir for influenza treatment
Hata A, Akashi-Ueda R, Takamatsu K, Matsumura T
Drug Design, Development and Therapy 2014, 8:2017-2038
Published Date: 24 October 2014
Decision-making in product portfolios of pharmaceutical research and development – managing streams of innovation in highly regulated markets
Jekunen A
Drug Design, Development and Therapy 2014, 8:2009-2016
Published Date: 21 October 2014
Immunomodulatory effects of 17-O-acetylacuminolide in RAW264.7 cells and HUVECs: involvement of MAPK and NF-κB pathways
Achoui M, Heyninck K, Looi CY, Mustafa AM, Haegeman G, Mustafa MR
Drug Design, Development and Therapy 2014, 8:1993-2007
Published Date: 20 October 2014
Risk factors associated with ineligibility of adjuvant cisplatin-based chemotherapy after nephroureterectomy
Shao IH, Lin YH, Hou CP, Juang HH, Chen CL, Chang PL, Tsui KH
Drug Design, Development and Therapy 2014, 8:1985-1991
Published Date: 21 October 2014
Efficacy of short novel antimicrobial and anti-inflammatory peptides in a mouse model of methicillin-resistant Staphylococcus aureus (MRSA) skin infection
Mohamed MF, Seleem MN
Drug Design, Development and Therapy 2014, 8:1979-1983
Published Date: 17 October 2014
Anticancer efficacy and absorption, distribution, metabolism, and toxicity studies of Aspergiolide A in early drug development
Wang Y, Qi X, Li D, Zhu T, Mo X, Li J
Drug Design, Development and Therapy 2014, 8:1965-1977
Published Date: 17 October 2014
Intestinal absorption, organ distribution, and urinary excretion of the rare sugar D-psicose
Tsukamoto I, Hossain A, Yamaguchi F, Hirata Y, Dong Y, Kamitori K, Sui L, Nonaka M, Ueno M, Nishimoto K, Suda H, Morimoto K, Shimonishi T, Saito M, Song T, Konishi R, Tokuda M
Drug Design, Development and Therapy 2014, 8:1955-1964
Published Date: 17 October 2014
Anti-inflammatory effects of cordycepin in lipopolysaccharide-stimulated RAW 264.7 macrophages through Toll-like receptor 4-mediated suppression of mitogen-activated protein kinases and NF-κB signaling pathways
Choi YH, Kim GY, Lee HH
Drug Design, Development and Therapy 2014, 8:1941-1953
Published Date: 16 October 2014
Indole and synthetic derivative activate chaperone expression to reduce polyQ aggregation in SCA17 neuronal cell and slice culture models
Kung PJ, Tao YC, Hsu HC, Chen WL, Lin TH, Janreddy D, Yao CF, Chang KH, Lin JY, Su MT, Wu CH, Lee-Chen GJ, Hsieh-Li HM
Drug Design, Development and Therapy 2014, 8:1929-1939
Published Date: 16 October 2014
Influence of caffeine and hyaluronic acid on collagen biosynthesis in human skin fibroblasts
Donejko M, Przylipiak A, Rysiak E, Głuszuk K, Surażyński A
Drug Design, Development and Therapy 2014, 8:1923-1928
Published Date: 15 October 2014
Animal models and therapeutic molecular targets of cancer: utility and limitations
Cekanova M, Rathore K
Drug Design, Development and Therapy 2014, 8:1911-1922
Published Date: 14 October 2014
Multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer’s disease: design, synthesis, biochemical evaluation, ADMET, molecular modeling, and QSAR analysis of novel donepezil-pyridyl hybrids
Bautista-Aguilera OM, Esteban G, Chioua M, Nikolic K, Agbaba D, Moraleda I, Iriepa I, Soriano E, Samadi A, Unzeta M, Marco-Contelles J
Drug Design, Development and Therapy 2014, 8:1893-1910
Published Date: 13 October 2014
Synthesis and biological evaluation of novel indole-2-one and 7-aza-2-oxindole derivatives as anti-inflammatory agents
Chen G, Jiang L, Dong L, Wang Z, Xu F, Ding T, Fu L, Fang Q, Liu Z, Shan X, Liang G
Drug Design, Development and Therapy 2014, 8:1869-1892
Published Date: 13 October 2014
Preclinical profile of cabazitaxel
Vrignaud P, Semiond D, Benning V, Beys E, Bouchard H, Gupta S
Drug Design, Development and Therapy 2014, 8:1851-1867
Published Date: 13 October 2014
Potent tumor targeting drug release system comprising MMP-2 specific peptide fragment with self-assembling characteristics
Hua D, Kong W, Zheng X, Zhou Z, Yu B, Li Y, Wang Y, Yang X, Liu C, Tang L, Li Y, Gong M
Drug Design, Development and Therapy 2014, 8:1839-1849
Published Date: 14 October 2014
Effects of an oral allosteric AKT inhibitor (MK-2206) on human nasopharyngeal cancer in vitro and in vivo
Zhao YY, Tian Y, Zhang J, Xu F, Yang YP, Huang Y, Zhao HY, Zhang JW, Xue C, Lam MH, Yan L, Hu ZH, Dinglin XX, Zhang L
Drug Design, Development and Therapy 2014, 8:1827-1837
Published Date: 10 October 2014
Topical pimecrolimus inhibits high-dose UVB irradiation-induced epidermal Langerhans cell migration, via regulation of TNF-a and E-cadherin
Yin Z, Xu J, Zhou B, Wu D, Xu Y, Zhang J, Luo D
Drug Design, Development and Therapy 2014, 8:1817-1825
Published Date: 10 October 2014
Development of polyether urethane intravaginal rings for the sustained delivery of hydroxychloroquine
Chen Y, Traore YL, Li A, Fowke KR, Ho EA
Drug Design, Development and Therapy 2014, 8:1801-1815
Published Date: 9 October 2014
Purification and in vitro antioxidant activities of tellurium-containing phycobiliproteins from tellurium-enriched Spirulina platensis
Yang F, Wong KH, Yang YF, Li XL, Jiang J, Zheng WJ, Wu HL, Chen TF
Drug Design, Development and Therapy 2014, 8:1789-1800
Published Date: 9 October 2014
Evaluation of the pharmacokinetic and pharmacodynamic drug interactions between cilnidipine and valsartan, in healthy volunteers
Lee J, Lee H, Jang K, Lim KS, Shin D, Yu KS
Drug Design, Development and Therapy 2014, 8:1781-1788
Published Date: 8 October 2014
(R)-(+)-α-Lipoic acid protected NG108-15 cells against H2O2-induced cell death through PI3K-Akt/GSK-3β pathway and suppression of NF-κβ-cytokines
Kamarudin MNA, Mohd Raflee NA, Syed Hussein SS, Lo JY, Supriady H, Abdul Kadir H
Drug Design, Development and Therapy 2014, 8:1765-1780
Published Date: 8 October 2014
Inhaled tyrosine kinase inhibitors for pulmonary hypertension: a possible future treatment
Pitsiou G, Zarogoulidis P, Petridis D, Kioumis I, Lampaki S, Organtzis J, Porpodis K, Papaiwannou A, Tsiouda T, Hohenforst-Schmidt W, Kakolyris S, Syrigos K, Huang H, Li Q, Turner JF, Zarogoulidis K
Drug Design, Development and Therapy 2014, 8:1753-1763
Published Date: 7 October 2014
Posttranslational regulation of phosphatase and tensin homolog (PTEN) and its functional impact on cancer behaviors
Xu WT, Yang Z, Zhou SF, Lu NH
Drug Design, Development and Therapy 2014, 8:1745-1751
Published Date: 6 October 2014
The comparative development of elevated resistance to macrolides in community-acquired pneumonia caused by Streptococcus pneumoniae
Yayan J
Drug Design, Development and Therapy 2014, 8:1733-1743
Published Date: 3 October 2014
Effect of renal function on the pharmacokinetics of fimasartan: a single-dose, open-label, Phase I study
Kim S, Lee J, Shin D, Lim KS, Kim YS, Jang IJ, Yu KS
Drug Design, Development and Therapy 2014, 8:1723-1731
Published Date: 6 October 2014
Multiple-dose pharmacokinetics and pharmacodynamics of evogliptin (DA-1229), a novel dipeptidyl peptidase IV inhibitor, in healthy volunteers
Gu N, Park MK, Kim TE, Bahng MY, Lim KS, Cho SH, Yoon SH, Cho JY, Jang IJ, Yu KS
Drug Design, Development and Therapy 2014, 8:1709-1721
Published Date: 6 October 2014
Effects of immunosuppressive treatment on protein expression in rat kidney
Kędzierska K, Sporniak-Tutak K, Sindrewicz K, Bober J, Domański L, Parafiniuk M, Urasińska E, Ciechanowicz A, Domański M, Smektała T, Masiuk M, Skrzypczak W, Ożgo M, Kabat-Koperska J, Ciechanowski K,
Drug Design, Development and Therapy 2014, 8:1695-1708
Published Date: 30 September 2014
Exploratory meta-analysis on lisdexamfetamine versus placebo in adult ADHD
Maneeton N, Maneeton B, Suttajit S, Reungyos J, Srisurapanont M, Martin SD
Drug Design, Development and Therapy 2014, 8:1685-1693
Published Date: 3 October 2014
An optimized probucol microencapsulated formulation integrating a secondary bile acid (deoxycholic acid) as a permeation enhancer
Mooranian A, Negrulj R, Chen-Tan N, Watts GF, Arfuso F, Al-Salami H
Drug Design, Development and Therapy 2014, 8:1673-1683
Published Date: 29 September 2014
Anticancer, antioxidant activities, and DNA affinity of novel monocationic bithiophenes and analogues
Ismail MA, Arafa RK, Yousssef MM, El-Sayed WM
Drug Design, Development and Therapy 2014, 8:1659-1672
Published Date: 29 September 2014
Fusion of cell-penetrating peptides to thermally responsive biopolymer improves tumor accumulation of p21 peptide in a mouse model of pancreatic cancer
Walker LR, Ryu JS, Perkins E, McNally LR, Raucher D
Drug Design, Development and Therapy 2014, 8:1649-1658
Published Date: 7 October 2014
α-Mangostin from Cratoxylum arborescens demonstrates apoptogenesis in MCF-7 with regulation of NF-κB and Hsp70 protein modulation in vitro, and tumor reduction in vivo
Ibrahim MY, Hashim NM, Mohan S, Abdulla MA, Kamalidehghan B, Ghaderian M, Dehghan F, Ali LZ, Arbab IA, Yahayu M, Lian GE, Ahmadipour F, Ali HM
Drug Design, Development and Therapy 2014, 8:1629-1647
Published Date: 27 September 2014
Buccal acetaminophen provides fast analgesia: two randomized clinical trials in healthy volunteers
Pickering G, Macian N, Libert F, Cardot JM, Coissard S, Perovitch P, Maury M, Dubray C
Drug Design, Development and Therapy 2014, 8:1621-1627
Published Date: 26 September 2014
Pharmacokinetics and tolerability of the new second-generation nonnucleoside reverse- transcriptase inhibitor KM-023 in healthy subjects
Cha YJ, Lim KS, Park MK, Schneider S, Bray B, Kang MC, Chung JY, Yoon SH, Cho JY, Yu KS
Drug Design, Development and Therapy 2014, 8:1613-1619
Published Date: 26 September 2014
EGFR mutations as a prognostic and predictive marker in non-small-cell lung cancer
Fang S, Wang Z
Drug Design, Development and Therapy 2014, 8:1595-1611
Published Date: 26 September 2014
Bioactive protein fraction DLBS1033 containing lumbrokinase isolated from Lumbricus rubellus: ex vivo, in vivo, and pharmaceutic studies
Tjandrawinata RR, Trisina J, Rahayu P, Prasetya LA, Hanafiah A, Rachmawati H
Drug Design, Development and Therapy 2014, 8:1585-1593
Published Date: 25 September 2014
Phyllostachys edulis extract induces apoptosis signaling in osteosarcoma cells, associated with AMPK activation
Chou CW, Cheng YW, Tsai CH
Drug Design, Development and Therapy 2014, 8:1577-1584
Published Date: 24 September 2014
Provisional in-silico biopharmaceutics classification (BCS) to guide oral drug product development
Wolk O, Agbaria R, Dahan A
Drug Design, Development and Therapy 2014, 8:1563-1575
Published Date: 24 September 2014
Clinical utility and development of the fluticasone/formoterol combination formulation (Flutiform®) for the treatment of asthma
Tan RA, Corren J
Drug Design, Development and Therapy 2014, 8:1555-1561
Published Date: 30 September 2014
Cross-sectional and longitudinal analysis of cancer vaccination trials registered on the US Clinical Trials Database demonstrates paucity of immunological trial endpoints and decline in registration since 2008
Lu L, Yan H, Shyam-Sundar V, Janowitz T
Drug Design, Development and Therapy 2014, 8:1539-1553
Published Date: 27 September 2014
Interferon-γ and celecoxib inhibit lung-tumor growth through modulating M2/M1 macrophage ratio in the tumor microenvironment
Ren F, Fan M, Mei J, Wu Y, Liu C, Pu Q, You Z, Liu L
Drug Design, Development and Therapy 2014, 8:1527-1538
Published Date: 23 September 2014
Synthesis and antibacterial activities of acylide derivatives bearing an aryl-tetrazolyl chain
Shan LX, Sun PH, Guo BQ, Xu XJ, Li ZQ, Sun JZ, Zhou SF, Chen WM
Drug Design, Development and Therapy 2014, 8:1515-1525
Published Date: 24 September 2014
Drug-likeness approach of 2-aminopyrimidines as histamine H3 receptor ligands
Sadek B, Schreeb A, Schwed JS, Weizel L, Stark H
Drug Design, Development and Therapy 2014, 8:1499-1513
Published Date: 19 September 2014
Ferulago angulata activates intrinsic pathway of apoptosis in MCF-7 cells associated with G1 cell cycle arrest via involvement of p21/p27
Karimian H, Moghadamtousi SZ, Fadaeinasab M, Golbabapour S, Razavi M, Hajrezaie M, Arya A, Abdulla MA, Mohan S, Ali HM, Noordin MI
Drug Design, Development and Therapy 2014, 8:1481-1497
Published Date: 22 September 2014
Enhanced bioavailability and anthelmintic efficacy of mebendazole in redispersible microparticles with low-substituted hydroxypropylcellulose
Torre-Iglesias PM, García-Rodriguez JJ, Torrado G, Torrado S, Torrado-Santiago S, Bolás-Fernández F
Drug Design, Development and Therapy 2014, 8:1467-1479
Published Date: 18 September 2014
Pemphigus erythematosus relapse associated with atorvastatin intake
Lo Schiavo A, Puca RV, Romano F, Cozzi R
Drug Design, Development and Therapy 2014, 8:1463-1465
Published Date: 18 September 2014
Defensive mechanism in cholangiocarcinoma cells against oxidative stress induced by chlorin e6-based photodynamic therapy
Lee HM, Chung CW, Kim CH, Kim DH, Kwak TW, Jeong YI, Kang DH
Drug Design, Development and Therapy 2014, 8:1451-1462
Published Date: 18 September 2014
Comparison of dexamethasone intravitreal implant and intravitreal triamcinolone acetonide for the treatment of pseudophakic cystoid macular edema in diabetic patients
Dang Y, Mu Y, Li L, Mu Y, Liu S, Zhang C, Zhu Y, Xu Y
Drug Design, Development and Therapy 2014, 8:1441-1449
Published Date: 18 September 2014
Time and dose relationships between schisandrin B- and schisandrae fructus oil-induced hepatotoxicity and the associated elevations in hepatic and serum triglyceride levels in mice
Zhang Y, Pan SY, Zhou SF, Wang XY, Sun N, Zhu PL, Chu ZS, Yu ZL, Ko KM
Drug Design, Development and Therapy 2014, 8:1429-1439
Published Date: 19 September 2014
Naltrexone sustained-release/bupropion sustained-release for the management of obesity: review of the data to date
Caixàs A, Albert L, Capel I, Rigla M
Drug Design, Development and Therapy 2014, 8:1419-1427
Published Date: 18 September 2014
Studies of synthetic chalcone derivatives as potential inhibitors of secretory phospholipase A2, cyclooxygenases, lipoxygenase and pro-inflammatory cytokines
Jantan I, Bukhari SNA, Adekoya OA, Sylte I
Drug Design, Development and Therapy 2014, 8:1405-1418
Published Date: 16 September 2014
Inhibition of urokinase plasminogen activator “uPA” activity alters ethanol consumption and conditioned place preference in mice
Al Maamari E, Al Ameri M, Al Mansouri S, Bahi A
Drug Design, Development and Therapy 2014, 8:1391-1403
Published Date: 16 September 2014
Diverse pathomechanisms leading to the breakdown of cellular estrogen surveillance and breast cancer development: new therapeutic strategies
Suba Z
Drug Design, Development and Therapy 2014, 8:1381-1390
Published Date: 11 September 2014
Update on developments with SGLT2 inhibitors in the management of type 2 diabetes
Nauck MA
Drug Design, Development and Therapy 2014, 8:1335-1380
Published Date: 11 September 2014
Aminaphtone in the control of gingival bleeding in children
Pereira de Godoy JM, Macedo Paizan ML
Drug Design, Development and Therapy 2014, 8:1331-1334
Published Date: 10 September 2014
Novel swellable polymer of orchidaceae family for gastroretentive drug delivery of famotidine
Razavi M, Nyamathulla S, Karimian H, Noordin MI
Drug Design, Development and Therapy 2014, 8:1315-1329
Published Date: 9 September 2014
Superior rejection profile during the first 24 months after heart transplantation under tacrolimus as baseline immunosuppressive regimen
Helmschrott M, Beckendorf J, Akyol C, Ruhparwar A, Schmack B, Erbel C, Gleissner CA, Akhavanpoor M, Ehlermann P, Bruckner T, Katus HA, Doesch AO
Drug Design, Development and Therapy 2014, 8:1307-1314
Published Date: 9 September 2014
Efficacy and safety of immunosuppressive therapy in the treatment of seronegative hepatitis associated aplastic anemia
Chen HF, Xu BX, Shen HS, Li ZY, Jin LJ, Tang JQ, Wang J, Zhu JJ, Qin LM, Cui QY, Ren YY, Wu TQ
Drug Design, Development and Therapy 2014, 8:1299-1305
Published Date: 9 September 2014
Synthesis and characterization of a glycine- modified heptamethine indocyanine dye for in vivo cancer-targeted near-infrared imaging
Liu T, Luo S, Wang Y, Tan X, Qi Q, Shi C
Drug Design, Development and Therapy 2014, 8:1287-1297
Published Date: 9 September 2014
Hydrogen sulfide, a potential novel drug, attenuates concanavalin A-induced hepatitis
Cheng P, Chen K, Xia Y, Dai WQ, Wang F, Shen M, Wang C, Yang J, Zhu R, Zhang H, Li JJ, Zheng Y, Wang J, Zhang Y, Lu J, Zhou YQ, Guo CY
Drug Design, Development and Therapy 2014, 8:1277-1286
Published Date: 9 September 2014
Update on the clinical utility and practical use of ropivacaine in Chinese patients
Li M, Wan L, Mei W, Tian Y
Drug Design, Development and Therapy 2014, 8:1269-1276
Published Date: 9 September 2014
N-n-butyl haloperidol iodide inhibits H2O2- induced Na+/Ca2+-exchanger activation via the Na+/H+ exchanger in rat ventricular myocytes
Huang YP, Gao FF, Wang B, Zheng FC, Zhang YM, Chen YC, Huang ZQ, Zheng YS, Zhong SP, Shi GG
Drug Design, Development and Therapy 2014, 8:1257-1267
Published Date: 9 September 2014
Single dose pharmacokinetic equivalence study of two gabapentin preparations in healthy subjects
Tjandrawinata RR, Setiawati E, Putri RSI, Yunaidi DA, Amalia F, Susanto LW
Drug Design, Development and Therapy 2014, 8:1249-1255
Published Date: 4 September 2014
Characterization and evaluation of amine-modified graphene amphotericin B for the treatment of visceral leishmaniasis: in vivo and in vitro studies
Mudavath SL, Talat M, Rai M, Srivastava ON, Sundar S
Drug Design, Development and Therapy 2014, 8:1235-1247
Published Date: 4 September 2014
Transient hypofibrinogenemia due to allopurinol
Yin ZQ, Xu JL, Li YQ, Xia JP, Luo D
Drug Design, Development and Therapy 2014, 8:1231-1233
Published Date: 2 September 2014
Microencapsulation as a novel delivery method for the potential antidiabetic drug, Probucol
Mooranian A, Negrulj R, Chen-Tan N, Al-Sallami HS, Fang Z, Mukkur TK, Mikov M, Golocorbin-Kon S, Fakhoury M, Watts GF, Matthews V, Arfuso F, Al-Salami H
Drug Design, Development and Therapy 2014, 8:1221-1230
Published Date: 9 September 2014
Combination therapy with sivelestat and recombinant human soluble thrombomodulin for ARDS and DIC patients
Miyoshi S, Ito R, Katayama H, Dote K, Aibiki M, Hamada H, Okura T, Higaki J
Drug Design, Development and Therapy 2014, 8:1211-1219
Published Date: 2 September 2014
Combining structure-based pharmacophore modeling, virtual screening, and in silico ADMET analysis to discover novel tetrahydro-quinoline based pyruvate kinase isozyme M2 activators with antitumor activity
Chen C, Wang T, Wu F, Huang W, He G, Ouyang L, Xiang M, Peng C, Jiang Q
Drug Design, Development and Therapy 2014, 8:1195-1210
Published Date: 2 September 2014
Update on the clinical utility of once-daily tacrolimus in the management of transplantation
Posadas Salas MA, Srinivas TR
Drug Design, Development and Therapy 2014, 8:1183-1194
Published Date: 1 September 2014
Remote ischemic conditioning improves coronary microcirculation in healthy subjects and patients with heart failure
Kono Y, Fukuda S, Hanatani A, Nakanishi K, Otsuka K, Taguchi H, Shimada K
Drug Design, Development and Therapy 2014, 8:1175-1181
Published Date: 27 August 2014
The efficacy of ampicillin and Lactobacillus casei rhamnosus in the active management of preterm premature rupture of membranes remote from term
Kavak SB, Kavak E, Ilhan R, Atilgan R, Arat O, Deveci U, Sapmaz E
Drug Design, Development and Therapy 2014, 8:1169-1173
Published Date: 30 August 2014
Effect of administration of water enriched in O2 by injection or electrolysis on transcutaneous oxygen pressure in anesthetized pigs
Charton A, Péronnet F, Doutreleau S, Lonsdorfer E, Klein A, Jimenez L, Geny B, Diemunsch P, Richard R
Drug Design, Development and Therapy 2014, 8:1161-1167
Published Date: 26 August 2014
Downregulated microRNA-148b in circulating PBMCs in chronic myeloid leukemia patients with undetectable minimal residual disease: a possible biomarker to discontinue imatinib safely
Ohyashiki JH, Ohtsuki K, Mizoguchi I, Yoshimoto T, Katagiri S, Umezu T, Ohyashiki K
Drug Design, Development and Therapy 2014, 8:1151-1159
Published Date: 25 August 2014
Design of an epitope-based peptide vaccine against spike protein of human coronavirus: an in silico approach
Oany AR, Emran AA, Jyoti TP
Drug Design, Development and Therapy 2014, 8:1139-1149
Published Date: 21 August 2014
Nasal saline as a placebo in a rhinosinusitis study
Karadag A, Catal F
Drug Design, Development and Therapy 2014, 8:1135-1137
Published Date: 20 August 2014
Pharmacokinetics and bioavailability of oxycodone and acetaminophen following single-dose administration of MNK-795, a dual-layer biphasic IR/ER combination formulation, under fed and fasted conditions
Devarakonda K, Morton T, Margulis R, Giuliani M, Barrett T
Drug Design, Development and Therapy 2014, 8:1125-1134
Published Date: 19 August 2014
Comparison of effects of anti-angiogenic agents in the zebrafish efficacy–toxicity model for translational anti-angiogenic drug discovery
Chimote G, Sreenivasan J, Pawar N, Subramanian J, Sivaramakrishnan H, Sharma S
Drug Design, Development and Therapy 2014, 8:1107-1123
Published Date: 19 August 2014
Predictive performance of gentamicin dosing nomograms
Lee J, Yoon S, Shin D, Han H, An H, Lee J, Lim KS, Yu KS, Lee H
Drug Design, Development and Therapy 2014, 8:1097-1106
Published Date: 16 August 2014
Investigation of aromatase inhibitory activity of metal complexes of 8-hydroxyquinoline and uracil derivatives
Prachayasittikul V, Pingaew R, Nantasenamat C, Prachayasittikul S, Ruchirawat S, Prachayasittikul V
Drug Design, Development and Therapy 2014, 8:1089-1096
Published Date: 14 August 2014
Safety and efficacy of S-1 chemotherapy in recurrent and metastatic nasopharyngeal carcinoma patients after failure of platinum-based chemotherapy: multi-institutional retrospective analysis
Peng PJ, Cheng H, Ou XQ, Zeng LJ, Wu X, Liu YM, Lin Z, Tang YN, Wang SY, Zhang HY, Chen ZB
Drug Design, Development and Therapy 2014, 8:1083-1087
Published Date: 14 August 2014
Meclofenamate elicits a nephropreventing effect in a rat model of ischemic acute kidney injury by suppressing indoxyl sulfate production and restoring renal organic anion transporters
Saigo C, Nomura Y, Yamamoto Y, Sagata M, Matsunaga R, Jono H, Nishi K, Saito H
Drug Design, Development and Therapy 2014, 8:1073-1082
Published Date: 13 August 2014
Optimization of nebulized delivery of linezolid, daptomycin, and vancomycin aerosol
Zarogoulidis P, Kioumis I, Lampaki S, Organtzis J, Porpodis K, Spyratos D, Pitsiou G, Petridis D, Pataka A, Huang H, Li Q, Yarmus L, Hohenforst-Schmidt W, Pezirkianidis N, Zarogoulidis K
Drug Design, Development and Therapy 2014, 8:1065-1072
Published Date: 12 August 2014
Efficacy of the small molecule inhibitor of Lipid II BAS00127538 against Acinetobacter baumannii
de Leeuw EPH
Drug Design, Development and Therapy 2014, 8:1061-1064
Published Date: 8 August 2014
Design, synthesis, and anticancer activity of novel berberine derivatives prepared via CuAAC “click” chemistry as potential anticancer agents
Jin X, Yan TH, Yan L, Li Q, Wang RL, Hu ZL, Jiang YY, Sun QY, Cao YB
Drug Design, Development and Therapy 2014, 8:1047-1059
Published Date: 6 August 2014
Clinical utility of erlotinib for the treatment of non-small-cell lung cancer in Japanese patients: current evidence
Togashi Y, Hayashi H, Nakagawa K, Nishio K
Drug Design, Development and Therapy 2014, 8:1037-1046
Published Date: 31 July 2014
Antimycobacterial, antimicrobial, and biocompatibility properties of para-aminosalicylic acid with zinc layered hydroxide and Zn/Al layered double hydroxide nanocomposites
Saifullah B, El Zowalaty ME, Arulselvan P, Fakurazi S, Webster TJ, Geilich BM, Hussein MZ
Drug Design, Development and Therapy 2014, 8:1029-1036
Published Date: 28 July 2014
Potential roles of GPR120 and its agonists in the management of diabetes
Zhang D, Leung PS
Drug Design, Development and Therapy 2014, 8:1013-1027
Published Date: 29 July 2014
Novel artificial cell microencapsulation of a complex gliclazide-deoxycholic bile acid formulation: a characterization study
Mooranian A, Negrulj R, Chen-Tan N, Al-Sallami HS, Fang Z, Mukkur T, Mikov M, Golocorbin-Kon S, Fakhoury M, Arfuso F, Al-Salami H
Drug Design, Development and Therapy 2014, 8:1003-1012
Published Date: 28 July 2014
Carbonic anhydrase IX-directed immunoliposomes for targeted drug delivery to human lung cancer cells in vitro
Wong BCK, Zhang H, Qin L, Chen H, Fang C, Lu A, Yang Z
Drug Design, Development and Therapy 2014, 8:993-1001
Published Date: 22 July 2014
Efficacy and pharmacokinetic activity of frovatriptan compared to rizatriptan in patients with moderate-to-severe migraine
Savi L, Mogavero S, Egan CG
Drug Design, Development and Therapy 2014, 8:983-992
Published Date: 21 July 2014
Sulforaphane reverses glucocorticoid-induced apoptosis in osteoblastic cells through regulation of the Nrf2 pathway
Lin H, Wei B, Li GS, Zheng JC, Sun JC, Chu JQ, Zeng R, Niu YR
Drug Design, Development and Therapy 2014, 8:973-982
Published Date: 19 July 2014
Evaluation of the biological activity of novel monocationic fluoroaryl-2,2’-bichalcophenes and their analogues
Hussin WA, Ismail MA, Alzahrani AM, El-Sayed WM
Drug Design, Development and Therapy 2014, 8:963-972
Published Date: 17 July 2014
Pustular drug eruption due to Panax notoginseng saponins
Yin ZQ, Ma LW, Xu JL, Xia JP, Luo D
Drug Design, Development and Therapy 2014, 8:957-961
Published Date: 16 July 2014
The load and release characteristics on a strong cationic ion-exchange fiber: kinetics, thermodynamics, and influences
Yuan J, Gao Y, Wang X, Liu H, Che X, Xu L, Yang Y, Wang Q, Wang Y, Li S
Drug Design, Development and Therapy 2014, 8:945-955
Published Date: 16 July 2014
Prostatic urethral angle might be a predictor of treatment efficacy of α-blockers in men with lower urinary tract symptoms
Hou CP, Chen CL, Lin YH, Tsai YL, Chang PL, Juang HH, Tsui KH
Drug Design, Development and Therapy 2014, 8:937-943
Published Date: 15 July 2014
A preliminary study of painless and effective transdermal botulinum toxin A delivery by jet nebulization for treatment of primary hyperhidrosis
Iannitti T, Palmieri B, Aspiro A, Di Cerbo A
Drug Design, Development and Therapy 2014, 8:931-935
Published Date: 14 July 2014
Profile and potential of ixabepilone in the treatment of pancreatic cancer
Smaglo BG, Pishvaian MJ
Drug Design, Development and Therapy 2014, 8:923-930
Published Date: 14 July 2014
Glycyrrhetinic acid-modified chitosan nanoparticles enhanced the effect of 5-fluorouracil in murine liver cancer model via regulatory T-cells [Retraction]
Cheng M, Xu H, Wang Y, Chen H, He B, Gao X, Li Y, Han J, Zhang Z
Drug Design, Development and Therapy 2014, 8:921-922
Published Date: 8 July 2014
Drug delivery options to increase patient adherence and satisfaction in the management of rheumatoid arthritis – focus on subcutaneous tocilizumab
Nakashima Y, Kondo M, Miyahara H, Iwamoto Y
Drug Design, Development and Therapy 2014, 8:913-919
Published Date: 4 July 2014
Dexmedetomidine for awake intubation and an opioid-free general anesthesia in a superobese patient with suspected difficult intubation
Gaszynski T, Gaszynska E, Szewczyk T
Drug Design, Development and Therapy 2014, 8:909-912
Published Date: 7 July 2014
Design of oral agents for the management of multiple sclerosis: benefit and risk assessment for dimethyl fumarate
Nicholas JA, Boster AL, Imitola J, O'Connell C, Racke MK
Drug Design, Development and Therapy 2014, 8:897-908
Published Date: 7 July 2014
New approaches to the management of schizophrenia: focus on aberrant hippocampal drive of dopamine pathways
Perez SM, Lodge DJ
Drug Design, Development and Therapy 2014, 8:887-896
Published Date: 2 July 2014
Treatment of pulmonary hypertension in idiopathic pulmonary fibrosis: shortfall in efficacy or trial design?
Nathan SD, King CS
Drug Design, Development and Therapy 2014, 8:875-885
Published Date: 2 July 2014
Virologic breakthrough in a patient with chronic hepatitis B by combination treatment with tenofovir disoproxil fumarate and entecavir
Suzuki F, Sezaki H, Akuta N, Suzuki Y, Kawamura Y, Hosaka T, Kobayashi M, Saitoh S, Arase Y, Ikeda K, Kobayashi M, Watahiki S, Mineta R, Suzuki Y, Kumada H
Drug Design, Development and Therapy 2014, 8:869-873
Published Date: 30 June 2014
Assessing the potential impact of non-proprietary drug copies on quality of medicine and treatment in patients with relapsing multiple sclerosis: the experience with fingolimod
Correale J, Chiquete E, Milojevic S, Frider N, Bajusz I
Drug Design, Development and Therapy 2014, 8:859-867
Published Date: 25 June 2014
Novel nanocrystal formulation of megestrol acetate has improved bioavailability compared with the conventional micronized formulation in the fasting state
Jang K, Yoon S, Kim SE, Cho JY, Yoon SH, Lim KS, Yu KS, Jang IJ, Lee H
Drug Design, Development and Therapy 2014, 8:851-858
Published Date: 25 June 2014
Clinical effectiveness and safety of montelukast in asthma. What are the conclusions from clinical trials and meta-analyses?
Hon KLE, Leung TF, Leung AKC
Drug Design, Development and Therapy 2014, 8:839-850
Published Date: 26 June 2014
Quetiapine for acute bipolar depression: a systematic review and meta-analysis
Suttajit S, Srisurapanont M, Maneeton N, Maneeton B
Drug Design, Development and Therapy 2014, 8:827-838
Published Date: 25 June 2014
Design of a new therapy to treat snake envenomation
Shahidi Bonjar L
Drug Design, Development and Therapy 2014, 8:819-825
Published Date: 18 June 2014
Use of metformin and vildagliptin for treatment of type 2 diabetes in the elderly
Sicras-Mainar A, Navarro-Artieda R
Drug Design, Development and Therapy 2014, 8:811-818
Published Date: 18 June 2014
Additive effects of cilnidipine, an L-/N-type calcium channel blocker, and an angiotensin II receptor blocker on reducing cardiorenal damage in Otsuka Long-Evans Tokushima Fatty rats with type 2 diabetes mellitus
Mori Y, Aritomi S, Niinuma K, Nakamura T, Matsuura K, Yokoyama J, Utsunomiya K
Drug Design, Development and Therapy 2014, 8:799-810
Published Date: 17 June 2014
New oral anticoagulants in patients with nonvalvular atrial fibrillation: a review of pharmacokinetics, safety, efficacy, quality of life, and cost effectiveness
Mani H, Lindhoff-Last E
Drug Design, Development and Therapy 2014, 8:789-798
Published Date: 17 June 2014
Vemurafenib: an evidence-based review of its clinical utility in the treatment of metastatic melanoma
Swaika A, Crozier JA, Joseph RW
Drug Design, Development and Therapy 2014, 8:775-787
Published Date: 16 June 2014
Review of nemonoxacin with special focus on clinical development
Qin X, Huang H
Drug Design, Development and Therapy 2014, 8:765-774
Published Date: 5 July 2014
Thrombolytic treatment (alteplase; rt-PA) in acute massive pulmonary embolism and cardiopulmonary arrest
Dirican A, Ozkaya S, Atas AE, Ulu EK, Kitapci I, Ece F
Drug Design, Development and Therapy 2014, 8:759-763
Published Date: 12 June 2014
Mapracorat, a selective glucocorticoid receptor agonist, causes apoptosis of eosinophils infiltrating the conjunctiva in late-phase experimental ocular allergy
Baiula M, Bedini A, Baldi J, Cavet ME, Govoni P, Spampinato S
Drug Design, Development and Therapy 2014, 8:745-757
Published Date: 10 June 2014
The new concepts on overcoming drug resistance in lung cancer
Zhang W, Lei P, Dong X, Xu C
Drug Design, Development and Therapy 2014, 8:735-744
Published Date: 6 June 2014
Evaluation of cytotoxic and chemotherapeutic properties of boldine in breast cancer using in vitro and in vivo models
Paydar M, Kamalidehghan B, Wong YL, Wong WF, Looi CY, Mustafa MR
Drug Design, Development and Therapy 2014, 8:719-733
Published Date: 6 June 2014
Optimization of biguanide derivatives as selective antitumor agents blocking adaptive stress responses in the tumor microenvironment
Narise K, Okuda K, Enomoto Y, Hirayama T, Nagasawa H
Drug Design, Development and Therapy 2014, 8:701-717
Published Date: 6 June 2014
Ivabradine, coronary artery disease, and heart failure: beyond rhythm control
Scicchitano P, Cortese F, Ricci G, Carbonara S, Moncelli M, Iacoviello M, Cecere A, Gesualdo M, Zito A, Caldarola P, Scrutinio D, Lagioia R, Riccioni G, Ciccone MM
Drug Design, Development and Therapy 2014, 8:689-700
Published Date: 3 June 2014
GLP-1(28-36)amide, the Glucagon-like peptide-1 metabolite: friend, foe, or pharmacological folly?
Taing MW, Rose FJ, Whitehead JP
Drug Design, Development and Therapy 2014, 8:677-688
Published Date: 3 June 2014
Progress of clinical research on targeted therapy combined with thoracic radiotherapy for non-small-cell lung cancer
Zhuang HQ, Zhao XZ, Zhao LJ, Chang JY, Wang P
Drug Design, Development and Therapy 2014, 8:667-675
Published Date: 29 May 2014
Evaluation of ceftiofur–PHBV microparticles in rats
Vilos C, Constandil L, Rodas PI, Cantin M, Zepeda K, Herrera N, Velasquez LA
Drug Design, Development and Therapy 2014, 8:651-666
Published Date: 29 May 2014
Neurotherapeutic activity of the recombinant heat shock protein Hsp70 in a model of focal cerebral ischemia in rats
Shevtsov MA, Nikolaev BP, Yakovleva LY, Dobrodumov AV, Dayneko AS, Shmonin AA, Vlasov TD, Melnikova EV, Vilisov AD, Guzhova IV, Ischenko AM, Mikhrina AL, Galibin OV, Yakovenko IV, Margulis BA
Drug Design, Development and Therapy 2014, 8:639-650
Published Date: 28 May 2014
Anxiolytic and antidepressant-like activities of the novel and potent non-imidazole histamine H3 receptor antagonist ST-1283
Bahi A, Schwed JS, Walter M, Stark H, Sadek B
Drug Design, Development and Therapy 2014, 8:627-637
Published Date: 28 May 2014
Is increasing the dose of Entecavir effective in partial virological responders?
Erturk A, Adnan Akdogan R, Parlak E, Cure E, Cumhur Cure M, Ozturk C
Drug Design, Development and Therapy 2014, 8:621-625
Published Date: 29 May 2014
Quinoxaline-substituted chalcones as new inhibitors of breast cancer resistance protein ABCG2: polyspecificity at B-ring position
Winter E, Gozzi GJ, Chiaradia-Delatorre LD, Daflon-Yunes N, Terreux R, Gauthier C, Mascarello A, Leal PC, Cadena SM, Yunes RA, Nunes RJ, Creczynski-Pasa TB, Di Pietro A
Drug Design, Development and Therapy 2014, 8:609-619
Published Date: 27 May 2014
Chronic obstructive pulmonary disease treated with inhaled medium- or high-dose corticosteroids: a prospective and randomized study focusing on clinical efficacy and the risk of pneumonia
Cheng SL, Su KC, Wang HC, Perng DW, Yang PC
Drug Design, Development and Therapy 2014, 8:601-607
Published Date: 28 May 2014
Cytoprotective effect of selective small-molecule caspase inhibitors against staurosporine-induced apoptosis
Wu J, Wang Y, Liang S, Ma H
Drug Design, Development and Therapy 2014, 8:583-600
Published Date: 24 May 2014
Pharmacoinformatics elucidation of potential drug targets against migraine to target ion channel protein KCNK18
Sehgal SA, Hassan M, Rashid S
Drug Design, Development and Therapy 2014, 8:571-581
Published Date: 21 May 2014
Profile of gantenerumab and its potential in the treatment of Alzheimer’s disease [Corrigendum]
Novakovic D, Feligioni M, Scaccianoce S, Caruso A, Piccinin S, Schepisi C, Errico F, Mercuri NB, Nicoletti F, Nisticò R
Drug Design, Development and Therapy 2014, 8:569-570
Published Date: 21 May 2014
Molecular pharmacodynamics of new oral drugs used in the treatment of multiple sclerosis
di Nuzzo L, Orlando R, Nasca C, Nicoletti F
Drug Design, Development and Therapy 2014, 8:555-568
Published Date: 19 May 2014
Protective effect of picroside II on myocardial ischemia reperfusion injury in rats
Wu N, Li W, Shu W, Jia D
Drug Design, Development and Therapy 2014, 8:545-554
Published Date: 14 May 2014
Effect of MMX® mesalamine coadministration on the pharmacokinetics of amoxicillin, ciprofloxacin XR, metronidazole, and sulfamethoxazole: results from four randomized clinical trials
Pierce D, Corcoran M, Martin P, Barrett K, Inglis S, Preston P, Thompson TN, Willsie SK
Drug Design, Development and Therapy 2014, 8:529-543
Published Date: 14 May 2014
The effects of sulodexide on both clinical and molecular parameters in patients with mixed arterial and venous ulcers of lower limbs
Serra R, Gallelli L, Conti A, De Caridi G, Massara M, Spinelli F, Buffone G, Caliò FG, Amato B, Ceglia S, Spaziano G, Scaramuzzino L, Ferrarese AG, Grande R, de Franciscis S
Drug Design, Development and Therapy 2014, 8:519-527
Published Date: 13 May 2014
Synthesis, antimicrobial, and anti-inflammatory activity, of novel S-substituted and N-substituted 5-(1-adamantyl)-1,2,4-triazole-3-thiols
Al-Abdullah ES, Asiri HH, Lahsasni S, Habib EE, Ibrahim TM, El-Emam AA
Drug Design, Development and Therapy 2014, 8:505-518
Published Date: 12 May 2014
Transdermal fentanyl for pain due to chemoradiotherapy-induced oral mucositis in nasopharyngeal cancer patients: evaluating efficacy, safety, and improvement in quality of life
Guo SP, Wu SG, Zhou J, Feng HX, Li FY, Wu YJ, Sun JY, He ZY
Drug Design, Development and Therapy 2014, 8:497-503
Published Date: 12 May 2014
Identification of a novel potential antitumor activity of gossypol as an APE1/Ref-1 inhibitor
Qian CY, Li MX, Sui JD, Ren T, Li Z, Zhang L, Zhou LW, Cheng Y, Wang D
Drug Design, Development and Therapy 2014, 8:485-496
Published Date: 9 May 2014
P-glycoprotein- and organic anion-transporting polypeptide-mediated transport of periplocin may lead to drug–herb/drug–drug interactions
Liang S, Deng FC, Xing HY, Wen H, Shi XY, Martey ON, Koomson E, He X
Drug Design, Development and Therapy 2014, 8:475-483
Published Date: 9 May 2014
Improving anticancer efficacy of (-)-epigallocatechin-3-gallate gold nanoparticles in murine B16F10 melanoma cells
Chen CC, Hsieh DS, Huang KJ, Chan YL, Hong PD, Yeh MK, Wu CJ
Drug Design, Development and Therapy 2014, 8:459-474
Published Date: 8 May 2014
Inhibition of B7-1 (CD80) by RhuDex® reduces lipopolysaccharide-mediated inflammation in human atherosclerotic lesions
Doesch AO, Zhao L, Gleissner CA, Akhavanpoor M, Rohde D, Okuyucu D, Hakimi M, Dengler TJ, Katus HA, Erbel C
Drug Design, Development and Therapy 2014, 8:447-457
Published Date: 12 May 2014
Linagliptin: from bench to bedside
Doupis J
Drug Design, Development and Therapy 2014, 8:431-446
Published Date: 5 May 2014
Topical infliximab for the suppression of wound healing following experimental glaucoma filtration surgery
Turgut B, Eren K, Akın MM, Demir T, Kobat S
Drug Design, Development and Therapy 2014, 8:421-429
Published Date: 2 May 2014
Combined isosorbide dinitrate and ibuprofen as a novel therapy for muscular dystrophies: evidence from Phase I studies in healthy volunteers
Cossu MV, Cattaneo D, Fucile S, Pellegrino P, Baldelli S, Cozzi V, Capetti A, Clementi E
Drug Design, Development and Therapy 2014, 8:411-419
Published Date: 2 May 2014
Clinical efficacy of Spasmofen® suppository in the emergency treatment of renal colic: a randomized, double-blind, double-dummy comparative trial
Yakoot M, Salem A, Yousef S, Helmy S
Drug Design, Development and Therapy 2014, 8:405-410
Published Date: 2 May 2014
Formulation development for the orexin receptor antagonist almorexant: assessment in two clinical studies
Dingemanse J, Gehin M, Cruz HG, Hoever P
Drug Design, Development and Therapy 2014, 8:397-403
Published Date: 28 April 2014
Effects of switching from prandial premixed insulin therapy to basal plus two times bolus insulin therapy on glycemic control and quality of life in patients with type 2 diabetes mellitus
Ito H, Abe M, Antoku S, Omoto T, Shinozaki M, Nishio S, Mifune M, Togane M
Drug Design, Development and Therapy 2014, 8:391-396
Published Date: 23 April 2014
Triazole derivatives with improved in vitro antifungal activity over azole drugs
Yu S, Chai X, Wang Y, Cao Y, Zhang J, Wu Q, Zhang D, Jiang Y, Yan T, Sun Q
Drug Design, Development and Therapy 2014, 8:383-390
Published Date: 10 April 2014
Discovery and evaluation of asymmetrical monocarbonyl analogs of curcumin as anti-inflammatory agents
Zhang Y, Zhao C, He W, Wang Z, Fang Q, Xiao B, Liu Z, Liang G, Yang S
Drug Design, Development and Therapy 2014, 8:373-382
Published Date: 4 April 2014
Fc-fusion technology and recombinant FVIII and FIX in the management of the hemophilias
Mancuso ME, Mannucci PM
Drug Design, Development and Therapy 2014, 8:365-371
Published Date: 28 March 2014
Tocilizumab in the treatment of rheumatoid arthritis and beyond
Shetty A, Hanson R, Korsten P, Shawagfeh M, Arami S, Volkov S, Vila O, Swedler W, Shunaigat AN, Smadi S, Sawaqed R, Perkins D, Shahrara S, Sweiss NJ
Drug Design, Development and Therapy 2014, 8:349-364
Published Date: 28 March 2014
Anti-TNF therapy for juvenile idiopathic arthritis-related uveitis
Semeraro F, Arcidiacono B, Nascimbeni G, Angi M, Parolini B, Costagliola C
Drug Design, Development and Therapy 2014, 8:341-348
Published Date: 24 March 2014
Tetrandrine protects mouse retinal ganglion cells from ischemic injury
Li WY, Yang C, Lu J, Huang P, Barnstable CJ, Zhang C, Zhang SS
Drug Design, Development and Therapy 2014, 8:327-339
Published Date: 21 March 2014
Daclatasvir: potential role in hepatitis C [Corrigendum]
Lee C
Drug Design, Development and Therapy 2014, 8:325-326
Published Date: 20 March 2014
Genistein suppresses tumor necrosis factor α-induced inflammation via modulating reactive oxygen species/Akt/nuclear factor ΚB and adenosine monophosphate-activated protein kinase signal pathways in human synoviocyte MH7A cells
Li J, Li J, Yue Y, Hu Y, Cheng W, Liu R, Pan X, Zhang P
Drug Design, Development and Therapy 2014, 8:315-323
Published Date: 17 March 2014
Differential microRNA expression signatures and cell type-specific association with Taxol resistance in ovarian cancer cells
Kim YW, Kim EY, Jeon D, Liu JL, Kim H, Choi JW, Ahn WS
Drug Design, Development and Therapy 2014, 8:293-314
Published Date: 24 February 2014
Ulipristal acetate: a novel pharmacological approach for the treatment of uterine fibroids
Biglia N, Carinelli S, Maiorana A, D'Alonzo M, Lo Monte G, Marci R
Drug Design, Development and Therapy 2014, 8:285-292
Published Date: 20 February 2014
Paclitaxel: new uses for an old drug
Zhang D, Yang R, Wang S, Dong Z
Drug Design, Development and Therapy 2014, 8:279-284
Published Date: 20 February 2014
Combining rimonabant and fentanyl in a single entity: preparation and pharmacological results
Fernández-Fernández C, Callado LF, Girón R, Sánchez E, Erdozain AM, López-Moreno JA, Morales P, Rodríguez de Fonseca F, Fernández-Ruiz J, Goya P, Meana JJ, Martín MI, Jagerovic N
Drug Design, Development and Therapy 2014, 8:263-277
Published Date: 20 February 2014
Insulin induces drug resistance in melanoma through activation of the PI3K/Akt pathway
Chi M, Ye Y, Zhang XD, Chen J
Drug Design, Development and Therapy 2014, 8:255-262
Published Date: 17 February 2014
Efficacy and safety of febuxostat in the treatment of hyperuricemia in stable kidney transplant recipients
Sofue T, Inui M, Hara T, Nishijima Y, Moriwaki K, Hayashida Y, Ueda N, Nishiyama A, Kakehi Y, Kohno M
Drug Design, Development and Therapy 2014, 8:245-253
Published Date: 17 February 2014
Effect of vildagliptin add-on treatment to metformin on plasma asymmetric dimethylarginine in type 2 diabetes mellitus patients
Cakirca M, Karatoprak C, Zorlu M, Kiskac M, Kanat M, Cikrikcioglu MA, Soysal P, Hursitoglu M, Camli AA, Erkoc R, Abdul-Ghani M
Drug Design, Development and Therapy 2014, 8:239-243
Published Date: 14 February 2014
Characterization of renal biomarkers for use in clinical trials: biomarker evaluation in healthy volunteers
Brott DA, Adler SH, Arani R, Lovick SC, Pinches M, Furlong ST
Drug Design, Development and Therapy 2014, 8:227-237
Published Date: 13 February 2014
Difference in the effects of switching from Candesartan to Olmesartan or Telmisartan to Olmesartan in hypertensive patients with type 2 diabetes: the COTO study
Daikuhara H, Fukunaga K, Ohshima T
Drug Design, Development and Therapy 2014, 8:219-226
Published Date: 17 February 2014
Sinonasal inhalation of tobramycin vibrating aerosol in cystic fibrosis patients with upper airway Pseudomonas aeruginosa colonization: results of a randomized, double-blind, placebo-controlled pilot study
Mainz JG, Schädlich K, Schien C, Michl R, Schelhorn-Neise P, Koitschev A, Koitschev C, Keller PM, Riethmüller J, Wiedemann B, Beck JF
Drug Design, Development and Therapy 2014, 8:209-217
Published Date: 10 February 2014
Omalizumab, an anti-immunoglobulin E antibody: state of the art
Incorvaia C, Mauro M, Russello M, Formigoni C, Riario-Sforza GG, Ridolo E
Drug Design, Development and Therapy 2014, 8:197-207
Published Date: 7 February 2014
QSAR and docking studies on xanthone derivatives for anticancer activity targeting DNA topoisomerase IIα
Alam S, Khan F
Drug Design, Development and Therapy 2014, 8:183-195
Published Date: 31 January 2014
Significant roadblocks exist in developing sputum sample libraries for clinical validation of novel in vitro diagnostics
Dollow JM, Green JA
Drug Design, Development and Therapy 2014, 8:175-182
Published Date: 23 January 2014
Changes in surface expression of N-methyl-D-aspartate receptors in the striatum in a rat model of Parkinson's disease
Gan J, Qi C, Mao LM, Liu ZG
Drug Design, Development and Therapy 2014, 8:165-173
Published Date: 17 January 2014
Novel N-substituted aminobenzamide scaffold derivatives targeting the dipeptidyl peptidase-IV enzyme
Al-Balas QA, Sowaileh MF, Hassan MA, Qandil AM, Alzoubi KH, Mhaidat NM, Almaaytah AM, Khabour OF
Drug Design, Development and Therapy 2014, 8:129-163
Published Date: 16 January 2014
Comparative steady-state pharmacokinetic study of an extended-release formulation of itopride and its immediate-release reference formulation in healthy volunteers
Yoon S, Lee H, Kim TE, Lee S, Chee DH, Cho JY, Yu KS, Jang IJ
Drug Design, Development and Therapy 2014, 8:123-128
Published Date: 15 January 2014
Clinical experimentation with aerosol antibiotics: current and future methods of administration [Corrigendum]
Zarogoulidis P, Kioumis I, Porpodis K, Spyratos D, Tsakiridis K, Huang H, Li Q, Turner JF, Browning R, Hohenforst-Schmidt W, Zarogoulidis K
Drug Design, Development and Therapy 2014, 8:121-122
Published Date: 16 January 2014
Does fesoterodine have a role in the treatment of poorly managed patients with overactive bladder?
Morris V, Wagg A
Drug Design, Development and Therapy 2014, 8:113-119
Published Date: 9 January 2014
Transdermal testosterone replacement therapy in men
Ullah MI, Riche DM, Koch CA
Drug Design, Development and Therapy 2014, 8:101-112
Published Date: 9 January 2014
Rituximab for the treatment of rheumatoid arthritis: an update
Mok CC
Drug Design, Development and Therapy 2014, 8:87-100
Published Date: 27 December 2013
Overview of clinical use and side effect profile of valsartan in Chinese hypertensive patients
Huang QF, Li Y, Wang JG
Drug Design, Development and Therapy 2014, 8:79-86
Published Date: 30 December 2013
Development and characterization of a gastroretentive dosage form composed of chitosan and hydroxyethyl cellulose for alendronate
Chen YC, Ho HO, Chiu CC, Sheu MT
Drug Design, Development and Therapy 2014, 8:67-78
Published Date: 27 December 2013
Development and use of sulodexide in vascular diseases: implications for treatment
Coccheri S, Mannello F
Drug Design, Development and Therapy 2014, 8:49-65
Published Date: 24 December 2013
(+)-Grandifloracin, an antiausterity agent, induces autophagic PANC-1 pancreatic cancer cell death
Ueda JY, Athikomkulchai S, Miyatake R, Saiki I, Esumi H, Awale S
Drug Design, Development and Therapy 2014, 8:39-47
Published Date: 18 December 2013
Lixisenatide as add-on therapy to basal insulin
Brown DX, Butler EL, Evans M
Drug Design, Development and Therapy 2014, 8:25-38
Published Date: 13 December 2013
Clinical utility of entecavir for chronic hepatitis B in Chinese patients
Wang JY
Drug Design, Development and Therapy 2014, 8:13-24
Published Date: 12 December 2013
Therapeutic potentials of naringin on polymethylmethacrylate induced osteoclastogenesis and osteolysis, in vitro and in vivo assessments
Li N, Xu Z, Wooley PH, Zhang J, Yang SY
Drug Design, Development and Therapy 2014, 8:1-11
Published Date: 10 December 2013