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Therapeutics and Clinical Risk Management
ISSN: 1178-203X
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Archive: Volume 17, 2021

Efficacy and Safety of Artemisinin-Based Combination Therapy for the Treatment of Uncomplicated Malaria in Pregnant Women: A Systematic Review and Meta-Analysis
Shibeshi W, Baye AM, Alemkere G, Engidawork E
Therapeutics and Clinical Risk Management 2021, 17:1353-1370
Published Date: 22 December 2021

Current Opinions on the Clinical Utility of Ravulizumab for the Treatment of Paroxysmal Nocturnal Hemoglobinuria
Gurnari C, Nautiyal I, Pagliuca S
Therapeutics and Clinical Risk Management 2021, 17:1343-1351
Published Date: 14 December 2021
Emotional Distress is Associated with Lower Health-Related Quality of Life Among Patients with Diabetes Using Antihypertensive and/or Antihyperlipidemic Medications: A Multicenter Study in Indonesia
Alfian SD, Annisa N, Iskandarsyah A, Perwitasari DA, Denig P, Hak E, Abdulah R
Therapeutics and Clinical Risk Management 2021, 17:1333-1342
Published Date: 7 December 2021

The Effects of Oral Sodium Bicarbonate on Renal Function and Cardiovascular Risk in Patients with Chronic Kidney Disease: A Systematic Review and Meta-Analysis
Cheng F, Li Q, Wang J, Wang Z, Zeng F, Zhang Y
Therapeutics and Clinical Risk Management 2021, 17:1321-1331
Published Date: 7 December 2021

Mortality and Readmission Rates After Heart Failure: A Systematic Review and Meta-Analysis
Lan T, Liao YH, Zhang J, Yang ZP, Xu GS, Zhu L, Fan DM
Therapeutics and Clinical Risk Management 2021, 17:1307-1320
Published Date: 7 December 2021
Dentists should be more familiar with systemic management [Response To Letter]
Sato H, Tamanoi T, Suzuki T, Moriyama H, Abe S, Yoshida K, Kawaai H, Yamazaki S
Therapeutics and Clinical Risk Management 2021, 17:1305-1306
Published Date: 6 December 2021
MTA1 Expression Can Stratify the Risk of Patients with Multifocal Non-Small Cell Lung Cancers ≤3 cm
Wang W, Hu Z, Ma M, Yin H, Huang Y, Zhao G, Cui X, Sun Q, Yang Y, Yang Y, Wang B, Ye L
Therapeutics and Clinical Risk Management 2021, 17:1295-1304
Published Date: 3 December 2021

Manual Removal versus Spontaneous Delivery of the Placenta at Cesarean Section: A Meta-Analysis of Randomized Controlled Trials
Yang MC, Li P, Su WJ, Jiang R, Deng J, Wang RR, Huang CL
Therapeutics and Clinical Risk Management 2021, 17:1283-1293
Published Date: 2 December 2021

Chronic Intractable Pruritus in Chronic Kidney Disease Patients: Prevalence, Impact, and Management Challenges — A Narrative Review
Świerczyńska K, Białynicki-Birula R, Szepietowski JC
Therapeutics and Clinical Risk Management 2021, 17:1267-1282
Published Date: 30 November 2021

Malayan Pit Viper Envenomation and Treatment in Thailand
Tangtrongchitr T, Thumtecho S, Janprasert J, Sanprasert K, Tongpoo A, Tanpudsa Y, Trakulsrichai S, Wananukul W, Srisuma S
Therapeutics and Clinical Risk Management 2021, 17:1257-1266
Published Date: 30 November 2021

Factors Affecting Squatting Ability in Total Knee Arthroplasty Using High Flexion Prosthesis

Li T, Sun J, Du Y, Gao Z, Ma H, Zhou Y
Therapeutics and Clinical Risk Management 2021, 17:1249-1256
Published Date: 30 November 2021
A Prognostic Model Incorporating Red Cell Distribution Width to Platelet Ratio for Patients with Traumatic Brain Injury
Wang R, He M, Zhang J, Wang S, Xu J
Therapeutics and Clinical Risk Management 2021, 17:1239-1248
Published Date: 26 November 2021
Utility of a Ruler for Reconstructed Auricle Positioning
Sun P, Lu M, Wang C, Pan B
Therapeutics and Clinical Risk Management 2021, 17:1231-1238
Published Date: 25 November 2021

Efficacy and Safety of Teprotumumab in Thyroid Eye Disease
Teo HM, Smith TJ, Joseph SS
Therapeutics and Clinical Risk Management 2021, 17:1219-1230
Published Date: 25 November 2021

Clinical Efficacy and Cost Analysis of Antibiotics for Treatment of Uncomplicated Urinary Tract Infections in the Emergency Department of a Tertiary Hospital in Saudi Arabia
Alanazi MQ
Therapeutics and Clinical Risk Management 2021, 17:1209-1217
Published Date: 21 November 2021

Treatment of Osteoarthritis Secondary to Severe Coxa Vara with Modular Total Hip Arthroplasty
Zhang B, Sun J, Du Y, Shen J, Li T, Zhou Y
Therapeutics and Clinical Risk Management 2021, 17:1199-1207
Published Date: 19 November 2021

Safety of Chloroquine or Hydroxychloroquine Plus Azithromycin for the Treatment of COVID-19 Patients in Burkina Faso: An Observational Prospective Cohort Study
Rouamba T, Barry H, Ouédraogo E, Tahita MC, Yaméogo NV, Poda A, Diendéré AE, Ouedraogo AS, Valea I, Koné AM, Thiombiano C, Traoré I, Tarnagda Z, Sawadogo SA, Gansané Z, Kambiré Y, Sanou I, Barro-Traoré F, Drabo MK, Tinto H
Therapeutics and Clinical Risk Management 2021, 17:1187-1198
Published Date: 15 November 2021

Benefits of Incremental Hemodialysis Seen in a Historical Cohort Study
Chen W, Wang M, Zhang M, Zhang W, Shi J, Weng J, Huang B, Kalantar-Zadeh K, Chen J
Therapeutics and Clinical Risk Management 2021, 17:1177-1186
Published Date: 13 November 2021

Drug-Related Problems Among Ambulatory Heart Failure Patients on Follow-Up at Debre Berhan Comprehensive Specialized Hospital, Ethiopia
Tsige AW, Yikna BB, Altaye BM
Therapeutics and Clinical Risk Management 2021, 17:1165-1175
Published Date: 10 November 2021
In Reference to Risk Perception of Septic Shock with Multiple Organ Failure Due to Acute Exacerbation of an Infectious Dental Disease [Letter]
Baba Y, Takada S, Kato Y
Therapeutics and Clinical Risk Management 2021, 17:1163-1164
Published Date: 4 November 2021
Risk Factors and Clinical Outcomes of 54 Cases of Rectal Neuroendocrine Tumors with Incomplete Resection: A Retrospective Single-Center Study
Li Y, Pan F, Sun G, Wang ZK, Meng K, Peng LH, Lu ZS, Dou Y, Yan B, Liu QS
Therapeutics and Clinical Risk Management 2021, 17:1153-1161
Published Date: 3 November 2021
Different Effect of Lanthanum Carbonate and Sevelamer Hydrochloride on Calcium Balance in Patients with Moderate to Advanced Chronic Kidney Disease
Makowka A, Nowicki M
Therapeutics and Clinical Risk Management 2021, 17:1145-1151
Published Date: 2 November 2021
Clinical and Histopathological Characteristics of Tumors Arising in Seborrheic Keratosis: A Study of 1365 Cases
Ye Q, Chen KJ, Jia M, Fang S
Therapeutics and Clinical Risk Management 2021, 17:1135-1143
Published Date: 27 October 2021
Reexamining Ophthalmic Drugs, Safety and Tolerability in Phase 1 Clinical Trials
Muñoz-Villegas P, Navarro-Sánchez AA, Sánchez-Ríos A, Olvera-Montaño O, Baiza-Durán LM
Therapeutics and Clinical Risk Management 2021, 17:1123-1134
Published Date: 21 October 2021
Pretreatment Systemic Immune-Inflammation Index Predict Needs for Teeth Extractions for Locally Advanced Head and Neck Cancer Patients Undergoing Concurrent Chemoradiotherapy
Yilmaz B, Somay E, Selek U, Topkan E
Therapeutics and Clinical Risk Management 2021, 17:1113-1121
Published Date: 18 October 2021
Clinical Outcomes of Patients with Coronary Artery Diseases and Moderate Left Ventricular Dysfunction: Percutaneous Coronary Intervention versus Coronary Artery Bypass Graft Surgery
Wang S, Lyu Y, Cheng S, Liu J, Borah BJ
Therapeutics and Clinical Risk Management 2021, 17:1103-1111
Published Date: 15 October 2021
Time to Euthyroidism and Its Determinants Among Thyrotoxicosis Patients on Anti-Thyroid Drug Who Attend to Medical and Ambulatory Clinics of South Tigrai General Hospitals
Maldey H, Tadesse S, Alem AZ, Hagezom HM, Hagos Gufue Z
Therapeutics and Clinical Risk Management 2021, 17:1091-1101
Published Date: 15 October 2021

How Safe are Fluoroquinolones for Diabetic Patients? A Systematic Review of Dysglycemic and Neuropathic Effects of Fluoroquinolones
Althaqafi A, Ali M, Alzahrani Y, Ming LC, Hussain Z
Therapeutics and Clinical Risk Management 2021, 17:1083-1090
Published Date: 13 October 2021

Cost-Effectiveness of Ferrous Fumarate–Folic Acid and Ferrous Gluconate–Multivitamins in a High Prevalence Area of Iron Deficiency Anemia in Indonesia
Rakanita Y, Syamsunarno MRAA, Sinuraya RK, Suradji EW, Abdulah R, Suwantika AA
Therapeutics and Clinical Risk Management 2021, 17:1075-1081
Published Date: 1 October 2021
Associations of LRP5 and MTHFR Gene Variants with Osteoarthritis Prevalence in Elderly Women: A Japanese Cohort Survey Randomly Sampled from a Basic Resident Registry
Nakano M, Yui H, Kikugawa S, Tokida R, Sakai N, Kondo N, Endo N, Haro H, Shimodaira H, Suzuki T, Kato H, Takahashi J, Nakamura Y
Therapeutics and Clinical Risk Management 2021, 17:1065-1073
Published Date: 29 September 2021

Novel Clinically Weight-Optimized Dynamic Conformal Arcs (WO-DCA) for Liver SBRT: A Comparison with Volumetric Modulated Arc Therapy (VMAT)
Saglam Y, Bolukbasi Y, Atasoy AI, Karakose F, Budak M, Alpan V, Topkan E, Selek U
Therapeutics and Clinical Risk Management 2021, 17:1053-1064
Published Date: 28 September 2021
Bioinformatics Analysis of a Functional ANGPT1 Variant That Interferes with miR-607 and Its Association with Susceptibility and Outcome of Ischemic Stroke in a Han Population
Chen AN, Zhong LL, Ju K, Cao H
Therapeutics and Clinical Risk Management 2021, 17:1045-1052
Published Date: 28 September 2021

More Pronounced Muscle Loss During Immunochemotherapy is Associated with Worse Clinical Outcomes in Newly Diagnosed Patients with Diffuse Large B-Cell Lymphoma with Unfavorable Features
Lucijanic M, Huzjan Korunic R, Sedinic M, Kusec R, Pejsa V
Therapeutics and Clinical Risk Management 2021, 17:1037-1044
Published Date: 24 September 2021

Topography-Guided Trans-Epithelial No-Touch Photorefractive Keratectomy for High Irregular Astigmatism After Penetrating Keratoplasty: A Prospective 12-Months Follow-Up
Spadea L, Visioli G, Mastromarino D, Alexander S, Pistella S
Therapeutics and Clinical Risk Management 2021, 17:1027-1035
Published Date: 24 September 2021

Doxycycline in the Coronavirus Disease 2019 Therapy
Dorobisz K, Dorobisz T, Janczak D, Zatoński T
Therapeutics and Clinical Risk Management 2021, 17:1023-1026
Published Date: 21 September 2021

The Influence of COVID-19 Lockdown in Jordan on Patients with Diabetic Retinopathy: A Case–Control Study
Al-Dwairi RA, Rwashdeh H, Otoom M
Therapeutics and Clinical Risk Management 2021, 17:1011-1022
Published Date: 14 September 2021
Lipid-Free PN is Associated with an Increased Risk of Hyperbilirubinemia in Surgical Critically Ill Patients with Admission Hepatic Disorder: A Retrospective Observational Study
Wu SC, Chen TA, Cheng HT, Chang YJ, Wang YC, Tzeng CW, Hsu CH, Muo CH
Therapeutics and Clinical Risk Management 2021, 17:1001-1010
Published Date: 14 September 2021

Safety and Efficacy of Tafenoquine for Plasmodium vivax Malaria Prophylaxis and Radical Cure: Overview and Perspectives
Markus MB
Therapeutics and Clinical Risk Management 2021, 17:989-999
Published Date: 8 September 2021
Comparative Results Between “Epi-Off” Accelerated and “Epi-Off” Standard Corneal Collagen Crosslinking-UVA in Progressive Keratoconus – 7 Years of Follow-Up
Nicula CA, Rednik AM, Nicula AP, Bulboaca AE, Nicula D, Horvath KU
Therapeutics and Clinical Risk Management 2021, 17:975-988
Published Date: 7 September 2021
Evaluating the Prognostic Role of Monocytopenia in Chemotherapy-Induced Febrile Neutropenia Patients Treated with Granulocyte Colony-Stimulating Factor
Alshari O, Al Zu’bi YO, Al Sharie AH, Wafai FH, Aleshawi AJ, Atawneh FH, Obeidat HA, Daoud MN, Khrais MZ, Albals D, Tubaishat F
Therapeutics and Clinical Risk Management 2021, 17:963-973
Published Date: 7 September 2021

Optimized Machine Learning Models to Predict In-Hospital Mortality for Patients with ST-Segment Elevation Myocardial Infarction
Zhao J, Zhao P, Li C, Hou Y
Therapeutics and Clinical Risk Management 2021, 17:951-961
Published Date: 4 September 2021

Adverse Drug Reactions of Acetylcholinesterase Inhibitors in Older People Living with Dementia: A Comprehensive Literature Review
Ruangritchankul S, Chantharit P, Srisuma S, Gray LC
Therapeutics and Clinical Risk Management 2021, 17:927-949
Published Date: 4 September 2021
Visual Performance Following Bilateral Implantation of Refractive Rotationally Asymmetric Bifocal Intraocular Lens (LS-313 MF30) or Apodized Diffractive Bifocal Intraocular Lens (ReSTOR SN6AD1)
Li H, Liu D, Gao H, Sun J, Bai H, Wu X
Therapeutics and Clinical Risk Management 2021, 17:917-926
Published Date: 1 September 2021

Association Analysis of Insulin Resistance and Osteoporosis Risk in Chinese Patients with T2DM
Wang X, Jiang L, Shao X
Therapeutics and Clinical Risk Management 2021, 17:909-916
Published Date: 31 August 2021

The Relationship of Drug Therapy to Aplastic Anemia in Pakistan: A Hospital-Based Case Control Study
Syed MA, Atta Ur Rahman A, Syed MNS, Memon NM
Therapeutics and Clinical Risk Management 2021, 17:903-908
Published Date: 27 August 2021
Identification of Hub Gene TIMP1 and Relative ceRNAs Regulatory Network in Colorectal Cancer
Qin YF, Li GM, Wang G, Kong DJ, Wang HD, Zhao YM, Hao JP, Qin H, Sun DQ, Wang H
Therapeutics and Clinical Risk Management 2021, 17:889-901
Published Date: 27 August 2021

Adverse Events Related to Off-Label Drugs Using Spontaneous Adverse Event Reporting Systems
Han N, Oh JM, Kim IW
Therapeutics and Clinical Risk Management 2021, 17:877-887
Published Date: 21 August 2021
Nomogram for the Prediction of Intrahospital Mortality Risk of Patients with ST-Segment Elevation Myocardial Infarction Complicated with Hyperuricemia: A Multicenter Retrospective Study
Bai Z, Ma Y, Shi Z, Li T, Hu S, Shi B
Therapeutics and Clinical Risk Management 2021, 17:863-875
Published Date: 21 August 2021
The Correlation Between Low Serum T3 Levels and All-Cause and Cardiovascular Mortality in Peritoneal Dialysis Patients
Xu LC, Zhou FF, Li M, Dai ZW, Cai KD, Zhu BX, Luo Q
Therapeutics and Clinical Risk Management 2021, 17:851-861
Published Date: 19 August 2021
Clinical Characteristics and Factors Associated with Disease Progression of Mild to Moderate COVID-19 Patients in a Makeshift (Fangcang) Hospital: A Retrospective Cohort Study
Liu J, Zhang JF, Ma HN, Feng K, Chen ZW, Yang LS, Mei B, Zhang JJ
Therapeutics and Clinical Risk Management 2021, 17:841-850
Published Date: 16 August 2021
Effect of the Timing of Surgery on Neurological Recovery for Patients with Incomplete Paraplegia Caused by Metastatic Spinal Cord Compression
Cui Y, Shi X, Li C, Mi C, Wang B, Pan Y, Lin Y
Therapeutics and Clinical Risk Management 2021, 17:831-840
Published Date: 13 August 2021

The Role of Dapagliflozin in the Management of Heart Failure: An Update on the Emerging Evidence
Gupta M, Rao S, Manek G, Fonarow GC, Ghosh RK
Therapeutics and Clinical Risk Management 2021, 17:823-830
Published Date: 12 August 2021
Analysis of Bleeding Site to Identify Associated Risk Factors of Intractable Epistaxis
Liao Z, Guo J, Mi J, Liao W, Chen S, Huang Y, Xu Y, Zhang J, Yang Q, Hong H
Therapeutics and Clinical Risk Management 2021, 17:817-822
Published Date: 12 August 2021
Short- to Mid-Term Clinical Outcomes of Posterior-Stabilized Cementless Total Knee Arthroplasty with Trabecular Metal Components
Momose T, Nakamura Y, Nakano M, Maeda T, Morioka S, Sobajima A, Nakatsuchi Y, Takahashi J, Nawata M
Therapeutics and Clinical Risk Management 2021, 17:809-816
Published Date: 10 August 2021
To Find Out the Relationship Between Levels of Glycosylated Hemoglobin with Meibomian Gland Dysfunction in Patients with Type 2 Diabetes
Fan F, Li X, Li K, Jia Z
Therapeutics and Clinical Risk Management 2021, 17:797-807
Published Date: 6 August 2021
Contrast-Enhanced Intraoperative Ultrasonography with Kupffer Phase May Change Treatment Strategy of Metastatic Liver Tumors – A Single-Centre Prospective Study
Li C, Liu Y, Xu J, Song J, Wu M, Chen J
Therapeutics and Clinical Risk Management 2021, 17:789-796
Published Date: 31 July 2021

Risk Factors of Mechanical Ventilation in Premature Infants During Hospitalization
Yue G, Wang J, Li H, Li B, Ju R
Therapeutics and Clinical Risk Management 2021, 17:777-787
Published Date: 30 July 2021

Ocrelizumab for the Treatment of Multiple Sclerosis: Safety, Efficacy, and Pharmacology
Mancinelli CR, De Rossi N, Capra R
Therapeutics and Clinical Risk Management 2021, 17:765-776
Published Date: 30 July 2021

Assessing the Safety and Efficacy of Trifarotene in the Treatment of Acne Vulgaris
Brumfiel CM, Patel MH, Bell KA, Cardis MA
Therapeutics and Clinical Risk Management 2021, 17:755-763
Published Date: 26 July 2021


Happiness: A Novel Outcome Measure in Stroke?


Wijeratne T, Sales C, Wijeratne C, Jakovljevic M
Therapeutics and Clinical Risk Management 2021, 17:747-754
Published Date: 27 July 2021

Optimal Use of Perampanel in Asian Patients with Epilepsy: Expert Opinion
Chinvarun Y, Huang CW, Wu Y, Lee HF, Likasitwattanakul S, Ding J, Yamamoto T
Therapeutics and Clinical Risk Management 2021, 17:739-746
Published Date: 21 July 2021

Visual Performances of a New Extended Depth-of-Focus Intraocular Lens with a Refractive Design: A Prospective Study After Bilateral Implantation
Spadea L, Giannico MI, Formisano M, Alisi L
Therapeutics and Clinical Risk Management 2021, 17:727-738
Published Date: 16 July 2021
Serum Hypoxia-Inducible Factor 1alpha Levels Correlate with Outcomes After Intracerebral Hemorrhage
Cai Y, Zhuang YK, Wu XY, Dong XQ, Du Q, Yu WH, Wang KY, Hu W, Zheng YK
Therapeutics and Clinical Risk Management 2021, 17:717-726
Published Date: 13 July 2021

Clopidogrel-Induced Interstitial Lung Disease: A Case Report
An J, Lee SH, Chang B
Therapeutics and Clinical Risk Management 2021, 17:711-715
Published Date: 12 July 2021

Update on Diagnosis and Treatment of Adult Pulmonary Alveolar Proteinosis
Iftikhar H, Nair GB, Kumar A
Therapeutics and Clinical Risk Management 2021, 17:701-710
Published Date: 10 August 2021

High Pretreatment Platelet-to-Albumin Ratio Predicts Poor Survival Results in Locally Advanced Nasopharyngeal Cancers Treated with Chemoradiotherapy
Haksoyler V, Topkan E
Therapeutics and Clinical Risk Management 2021, 17:691-700
Published Date: 5 July 2021

Correlation Between Calcification Characteristics of Carotid Atherosclerotic Plaque and Plaque Vulnerability
Xu X, Hua Y, Liu B, Zhou F, Wang L, Hou W
Therapeutics and Clinical Risk Management 2021, 17:679-690
Published Date: 1 July 2021

Adverse Events Induced by PD-1/PD-L1 Inhibitors: A Real-World Single-Centre Experience with a Management-Based Approach
Grimaud F, Penaranda G, Stavris C, Retornaz F, Brunel V, Cailleres S, Pegliasco H, Le Treut J, Grisoni V, Coquet E, Chiche L, Rognon A
Therapeutics and Clinical Risk Management 2021, 17:669-677
Published Date: 30 June 2021

Therapeutic Agents Rounding Up the Immunopathology of COVID-19
Li HP, He X, Zhang L, Li CX, Li SQ, Li QY
Therapeutics and Clinical Risk Management 2021, 17:657-668
Published Date: 29 June 2021

Safety Profile of Tolvaptan in the Treatment of Autosomal Dominant Polycystic Kidney Disease
Bellos I
Therapeutics and Clinical Risk Management 2021, 17:649-656
Published Date: 29 June 2021

Exploring the Effectiveness of PAC Rehabilitation for Elders with Hip Surgery: A Retrospective Study
Yang JL, Ou YH, Liu SY, Lin CH, Chang SW, Lu YH, Shen T, Hsieh CP, Lin CM, Lei RL
Therapeutics and Clinical Risk Management 2021, 17:641-648
Published Date: 23 June 2021
Arterial Embolism in Malignancy: The Role of Surgery
Harnarayan P, Islam S, Naraynsingh V
Therapeutics and Clinical Risk Management 2021, 17:635-640
Published Date: 18 June 2021
Efficacy of Lamellar Keratoplasty with Acellular Porcine Corneal Stroma in Treatment for Infectious Central and Peripheral Corneal Ulcers
Chen Y, Zhang L, Liu Z, Liu Q, Gao M
Therapeutics and Clinical Risk Management 2021, 17:623-634
Published Date: 10 June 2021
Italian Real-World Analysis of a Tyrosine Kinase Inhibitor Administration as First- or Second-Line of Therapy in Patients with Chronic Myeloid Leukemia
Perrone V, Giacomini E, Andretta M, Arenare L, Cillo MR, Latini M, Mecozzi A, Pagliaro R, Vercellone A, Degli Esposti L
Therapeutics and Clinical Risk Management 2021, 17:617-622
Published Date: 8 June 2021

Current Opinion on Prucalopride in Gastroparesis and Chronic Constipation Treatment: A Focus on Patient Selection and Safety
Hong JT
Therapeutics and Clinical Risk Management 2021, 17:601-615
Published Date: 8 June 2021

Gene Therapy for Overactive Bladder: A Review of BK-Channel α-Subunit Gene Transfer
Andersson KE, Christ GJ, Davies KP, Rovner ES, Melman A
Therapeutics and Clinical Risk Management 2021, 17:589-599
Published Date: 4 June 2021

Unresponsive Thrombotic Thrombocytopenic Purpura (TTP): Challenges and Solutions
Lemiale V, Valade S, Mariotte E
Therapeutics and Clinical Risk Management 2021, 17:577-587
Published Date: 3 June 2021
IgA Vasculitis in a Lung Cancer Patient During Chemoradiotherapy
Taoka M, Ochi N, Mimura A, Ichiyama N, Nagasaki Y, Nakagawa N, Nakanishi H, Yamane H, Oshiro Y, Monobe Y, Takigawa N
Therapeutics and Clinical Risk Management 2021, 17:571-575
Published Date: 3 June 2021
The Diagnostic Value of Plasma miRNA-497, cTnI, FABP3 and GPBB in Pediatric Sepsis Complicated with Myocardial Injury
Huang C, Xiao S, Xia Z, Cheng Y, Li Y, Tang W, Shi B, Qin C, Xu H
Therapeutics and Clinical Risk Management 2021, 17:563-570
Published Date: 1 June 2021

Establishment of a Clinical Nomogram Model to Predict the Progression of COVID-19 to Severe Disease
Tu C, Wang G, Geng Y, Guo N, Cui N, Liu J
Therapeutics and Clinical Risk Management 2021, 17:553-561
Published Date: 1 June 2021
Developing a Nomogram to Predict the Probability of Subsequent Vascular Events at 6-Month in Chinese Patients with Minor Ischemic Stroke
Du Y, Gu P, Cui Y, Wang Y, Ran J
Therapeutics and Clinical Risk Management 2021, 17:543-552
Published Date: 1 June 2021
Therapeutic Outcomes and Risk Factors for Complications of Endoscopic Papillectomy: A Retrospective Analysis of a Single-Center Study
Jiang L, Chai N, Li M, Linghu E
Therapeutics and Clinical Risk Management 2021, 17:531-541
Published Date: 28 May 2021

Non-Surgical Treatment of Knee Osteoarthritis: Multidisciplinary Italian Consensus on Best Practice
Pradelli L, Sinigaglia T, Migliore A, Checchia GA, Franceschi F, Frediani B, Iannone F, Romanini E
Therapeutics and Clinical Risk Management 2021, 17:507-530
Published Date: 28 May 2021

Parenteral Nutrition Process Management for Newborn and Preterm Infants – A Preliminary Risk Analysis
Sommer I, Palmero D, Fischer Fumeaux CJ, Bonnabry P, Bouchoud L, Sadeghipour F
Therapeutics and Clinical Risk Management 2021, 17:497-506
Published Date: 28 May 2021
Outcomes of Eyes Lost to Follow-Up in Patients with Central Retinal Vein Occlusion Who are Receiving Anti-Vascular Endothelial Growth Factor Treatment
Yang KB, Liu L, Feng H, Li J, Liu ZL, Liu HN, Zhang H
Therapeutics and Clinical Risk Management 2021, 17:489-496
Published Date: 26 May 2021

Current Opinion on the use of Direct Oral Anticoagulants for the Prophylaxis of Venous Thromboembolism among Medical Inpatients
Lee JJ, Memar Montazerin S, Shojaei F, Chi G
Therapeutics and Clinical Risk Management 2021, 17:471-487
Published Date: 26 May 2021
Tuberculosis Relapse in the Epididymis After the Completion of Nine Months of Anti-Tuberculosis Chemotherapy in a Patient with Poorly Controlled Diabetes Mellitus
Ichikawa C, Tanaka S, Takubo M, Kushimoto M, Ikeda J, Ogawa K, Tsujino I, Suzuki Y, Abe M, Ishihara H, Fujishiro M
Therapeutics and Clinical Risk Management 2021, 17:463-470
Published Date: 25 May 2021
Polymorphism of IL-1β rs16944(T/C) Associated with Serum Levels of IL-1β and Subsequent Stimulation of Extracellular Matrix Degradation Affects Intervertebral Disk Degeneration Susceptibility
Wang Z, Song X, Fang Q, Xia W, Luo A
Therapeutics and Clinical Risk Management 2021, 17:453-461
Published Date: 24 May 2021
Impact of Antecedent Aspirin Use on Infarct Size, Bleeding and Composite Endpoint in Patients with de Novo Acute Myocardial Infarction
Enhos A, Karacop E
Therapeutics and Clinical Risk Management 2021, 17:441-452
Published Date: 21 May 2021

Risk Factors for Cerebral Infarction After Moderate or Severe Traumatic Brain Injury
Wu Y, Chao Y, Gao G, Bao D, Dong Y, Wei X, Niu C
Therapeutics and Clinical Risk Management 2021, 17:433-440
Published Date: 21 May 2021

The Value of Chinese Version GAD-7 and PHQ-9 to Screen Anxiety and Depression in Chinese Outpatients with Atypical Chest Pain
Lin Q, Bonkano O, Wu K, Liu Q, Ali Ibrahim T, Liu L
Therapeutics and Clinical Risk Management 2021, 17:423-431
Published Date: 18 May 2021
Myocardial Injury After Temporary Transvenous Cardiac Pacing
Liu M, Wu P
Therapeutics and Clinical Risk Management 2021, 17:415-421
Published Date: 18 May 2021
Microvascular Changes in Macular Area After Phacoemulsification and Its Influencing Factors Assessed by Optical Coherence Tomography Angiography
Liu J, Liu Q, Yu H, Xia Y, Zhang H, Geng C, Dong L
Therapeutics and Clinical Risk Management 2021, 17:405-414
Published Date: 14 May 2021
Comparison of Behavioral Risk Factors and Cardiometabolic Comorbidities of Psoriatic Arthritis and Psoriasis: A Case–Control Study in Chinese Patients
Wang Q, Luo Y, Chen M, Zheng X, Zhu W, Shen M, Kuang Y
Therapeutics and Clinical Risk Management 2021, 17:397-404
Published Date: 3 May 2021

Changes in Distribution of Lower Limb Alignment After Total Hip Arthroplasty for Crowe IV Developmental Dysplasia of the Hip
Sun J, Guo L, Ni M, Shen J, Du Y, Zhang B, Zhang G, Zhou Y
Therapeutics and Clinical Risk Management 2021, 17:389-396
Published Date: 3 May 2021

Chloroquine and Hydroxychloroquine for the Prevention and Treatment of COVID-19: A Fiction, Hope or Hype? An Updated Review
Saghir SAM, AlGabri NA, Alagawany MM, Attia YA, Alyileili SR, Elnesr SS, Shafi ME, Al-shargi OYA, Al-balagi N, Alwajeeh AS, Alsalahi OS, Patra AK, Khafaga AF, Negida A, Noreldin A, Al-Amarat W, Almaiman AA, El-Tarabily KA, Abd El-Hack ME
Therapeutics and Clinical Risk Management 2021, 17:371-387
Published Date: 28 April 2021

Risk Perception of Septic Shock with Multiple Organ Failure Due to Acute Exacerbation of an Infectious Dental Disease
Sato H, Tamanoi T, Suzuki T, Moriyama H, Abe S, Yoshida K, Kawaai H, Yamazaki S
Therapeutics and Clinical Risk Management 2021, 17:365-369
Published Date: 22 April 2021

Continuous Negative Pressure Drainage with Intermittent Irrigation Leaded to a Risk Reduction of Perineal Surgical Site Infection Following Laparoscopic Extralevator Abdominoperineal Excision for Low Rectal Cancer
Han Z, Yang C, Wang Q, Wang M, Li X, Zhang C
Therapeutics and Clinical Risk Management 2021, 17:357-364
Published Date: 22 April 2021
Utilization of Healthcare Resources in Osteoarthritis: A Cost of Illness Analysis Based on Real-World Data in Italy
Colombo GL, Heiman F, Peduto I
Therapeutics and Clinical Risk Management 2021, 17:345-356
Published Date: 21 April 2021

Utility of Angioembolization in Patients with Abdominal and Pelvic Traumatic Bleeding: Descriptive Observational Analysis from a Level 1 Trauma Center
Al-Thani H, Abdelrahman H, Barah A, Asim M, El-Menyar A
Therapeutics and Clinical Risk Management 2021, 17:333-343
Published Date: 19 April 2021

Risk Factors for Tigecycline-Associated Hypofibrinogenemia
Liu J, Yan Y, Zhang F
Therapeutics and Clinical Risk Management 2021, 17:325-332
Published Date: 16 April 2021

Dietary and Lifestyle Factors Related to Gastroesophageal Reflux Disease: A Systematic Review
Zhang M, Hou ZK, Huang ZB, Chen XL, Liu FB
Therapeutics and Clinical Risk Management 2021, 17:305-323
Published Date: 15 April 2021

Clinical Management of Relapsed/Refractory Hemophagocytic Lymphohistiocytosis in Adult Patients: A Review of Current Strategies and Emerging Therapies
Yildiz H, Bailly S, Van Den Neste E, Yombi JC
Therapeutics and Clinical Risk Management 2021, 17:293-304
Published Date: 14 April 2021

Budesonide MMX in the Treatment of Ulcerative Colitis: Current Perspectives on Efficacy and Safety
Maconi G, Camatta D, Cannatelli R, Ferretti F, Carvalhas Gabrielli A, Ardizzone S
Therapeutics and Clinical Risk Management 2021, 17:285-292
Published Date: 7 April 2021

Total Knee Arthroplasty in Spondyloepiphyseal Dysplasia with Irreducible Congenital Dislocation of the Patella: Case Report and Literature Review
Sponer P, Korbel M, Kucera T
Therapeutics and Clinical Risk Management 2021, 17:275-283
Published Date: 30 March 2021
Heart Rate Predicts the Risk of New-Onset Peripheral Arterial Disease in a Community-Based Population in China
Gao Y, Fan F, Jia J, Jiang Y, He D, Wu Z, Huo Y, Zhou J, Zhang Y
Therapeutics and Clinical Risk Management 2021, 17:267-274
Published Date: 26 March 2021

Neutrophil/Lymphocyte Ratio as an Inflammatory Predictor of Dry Eye Disease: A Case-Control Study
Meng YF, Pu Q, Ma Q, Zhu W, Li XY
Therapeutics and Clinical Risk Management 2021, 17:259-266
Published Date: 23 March 2021

Left Ventricular Remodeling Risk Predicted by Two-Dimensional Speckle Tracking Echocardiography in Acute Myocardial Infarction Patients with Midrange or Preserved Ejection Fraction in Western Romania
Bordejevic DA, Pârvănescu T, Petrescu L, Mornoș C, Olariu I, Crișan S, Văcărescu C, Lazăr M, Morariu VI, Citu IM, Tomescu MC, Cozma D
Therapeutics and Clinical Risk Management 2021, 17:249-258
Published Date: 23 March 2021

Effects of Impacted Lower Third Molar Extraction on Periodontal Tissue of the Adjacent Second Molar
Zhang Y, Chen X, Zhou Z, Hao Y, Li H, Cheng Y, Ren X, Wang X
Therapeutics and Clinical Risk Management 2021, 17:235-247
Published Date: 22 March 2021
Drugs for the Treatment of Chronic Hand Eczema: Successes and Key Challenges [Corrigendum]
Dubin C, Del Duca E, Guttman-Yassky E
Therapeutics and Clinical Risk Management 2021, 17:233-234
Published Date: 18 March 2021

Review: A Safety Profile of Dalbavancin for On- and Off-Label Utilization
Simonetti O, Rizzetto G, Molinelli E, Cirioni O, Offidani A
Therapeutics and Clinical Risk Management 2021, 17:223-232
Published Date: 22 March 2021

Polycythemia Vera (PV): Update on Emerging Treatment Options
Benevolo G, Vassallo F, Urbino I, Giai V
Therapeutics and Clinical Risk Management 2021, 17:209-221
Published Date: 16 March 2021

Role of Alpelisib in the Treatment of PIK3CA-Mutated Breast Cancer: Patient Selection and Clinical Perspectives
Chang DY, Ma WL, Lu YS
Therapeutics and Clinical Risk Management 2021, 17:193-207
Published Date: 5 March 2021
Current Opinion on Pixantrone in the Treatment of Non-Hodgkin B-Cell Lymphoma
Jezeršek Novaković B, Boltežar L, Novaković A
Therapeutics and Clinical Risk Management 2021, 17:183-192
Published Date: 2 March 2021
Potentially Inappropriate Prescriptions to Older Patients in Emergency Departments in South Korea: A Retrospective Study
Kim K, Jung J, Kim H, Kim JT, Oh JM, Kim H
Therapeutics and Clinical Risk Management 2021, 17:173-181
Published Date: 19 February 2021
The Prevalence and Risk Factors of Cerebral Microbleeds: A Community-Based Study in China
Luo Q, Tang H, Xu X, Huang J, Wang P, He G, Song X, Huang Y, Chen S, Yan F, Tan Y, Ma J
Therapeutics and Clinical Risk Management 2021, 17:165-171
Published Date: 18 February 2021

Profile of Daprodustat in the Treatment of Renal Anemia Due to Chronic Kidney Disease
Ishii T, Tanaka T, Nangaku M
Therapeutics and Clinical Risk Management 2021, 17:155-163
Published Date: 17 February 2021
Development of a Risk Scoring System for Predicting Anastomotic Leakage Following Laparoscopic Rectal Cancer Surgery
Han Z, Chen D, Li Y, Zhou G, Wang M, Zhang C
Therapeutics and Clinical Risk Management 2021, 17:145-153
Published Date: 17 February 2021

Perioperative and Postoperative Complications of Supraclavicular, Ultrasound-Guided, Totally Implantable Venous Access Port via the Brachiocephalic Vein in Adult Patients: A Retrospective Multicentre Study
Yu Z, Sun X, Bai X, Ding W, Wang W, Xu L, Qin W, Wen L, Jin Y
Therapeutics and Clinical Risk Management 2021, 17:137-144
Published Date: 4 February 2021
Lung Function Assessment by Impulse Oscillometry in Adults [Corrigendum]
Porojan-Suppini N, Fira-Mladinescu O, Marc M, Tudorache E, Oancea C
Therapeutics and Clinical Risk Management 2021, 17:135-136
Published Date: 2 February 2021
Combination of Multiple Hemodialysis Modes: Better Treatment Options for Patients Under Maintenance Hemodialysis
Zhang ZY, Li MX, Yu H, Zhao J, Xiao FL, Xuan F, Zhao YX
Therapeutics and Clinical Risk Management 2021, 17:127-133
Published Date: 29 January 2021

Clinical Features of Segmental Infantile Hemangioma: A Prospective Study
Qiu T, Yang K, Dai S, Chen S, Ji Y
Therapeutics and Clinical Risk Management 2021, 17:119-125
Published Date: 27 January 2021

Long-Term Follow-Up and Clinical Relevance of Incidental Findings of Fibrin Sheath and Thrombosis on Computed Tomography Scans of Cancer Patients with Port Catheters
Lichtenstein T, Mammadov K, Rau K, Große Hokamp N, Do TD, Maintz D, Chang DH
Therapeutics and Clinical Risk Management 2021, 17:111-118
Published Date: 27 January 2021

Real-Time Ultrasound Detection of Left Paratracheal Esophagus on Air Entry into the Gastric Antrum in the Induction Period of General Anesthesia: A Prospective, Randomized Study
Li Z, Yuan X, Deng W
Therapeutics and Clinical Risk Management 2021, 17:103-109
Published Date: 28 January 2021
Perioperative Glucocorticoids are Associated with Improved Recurrence-Free Survival After Pancreatic Cancer Surgery: A Retrospective Cohort Study with Propensity Score-Matching
Zhang YX, Mu DL, Jin KM, Li XY, Wang DX
Therapeutics and Clinical Risk Management 2021, 17:87-101
Published Date: 22 January 2021

Effects of Scleral Contact Lenses for Keratoconus Management on Visual Quality and Intraocular Pressure
Formisano M, Franzone F, Alisi L, Pistella S, Spadea L
Therapeutics and Clinical Risk Management 2021, 17:79-85
Published Date: 25 January 2021
Evaluation of Antiemetic Therapy for Hepatic Arterial Infusion Chemotherapy with Oxaliplatin, Fluorouracil, and Leucovorin
Zhao Y, He M, Liang R, Li Q, Shi M
Therapeutics and Clinical Risk Management 2021, 17:73-77
Published Date: 22 January 2021
Growth Promoting Effect of Vacuum Sealing Drainage in the Healing Processes of Diabetic Foot Ulcers
Yang H, Liu L, Li G, Chen Y, Jiang D, Wang W, Wang T, Sun J, Che J, Gu D, Lu M, Wang A
Therapeutics and Clinical Risk Management 2021, 17:65-71
Published Date: 19 January 2021
The Diagnostic Value of Fe3+ and Inflammation Indicators in the Death of Sepsis Patients: A Retrospective Study of 428 Patients
Wang J, Wang J, Wei B
Therapeutics and Clinical Risk Management 2021, 17:55-63
Published Date: 15 January 2021

Emerging B-Cell Therapies in Systemic Lupus Erythematosus
Bag-Ozbek A, Hui-Yuen JS
Therapeutics and Clinical Risk Management 2021, 17:39-54
Published Date: 14 January 2021

Maternal and Neonatal Outcomes Resulting from Antepartum Hemorrhage in Women with Placenta Previa and Its Associated Risk Factors: A Single-Center Retrospective Study
Long SY, Yang Q, Chi R, Luo L, Xiong X, Chen ZQ
Therapeutics and Clinical Risk Management 2021, 17:31-38
Published Date: 12 January 2021
The Assessment of Dynamic Spinal Cord Impingement by Kinematic Magnetic Resonance Imaging in Patients with Traumatic Central Cord Syndrome
Li J, Shi D, Hua Z, Wang L
Therapeutics and Clinical Risk Management 2021, 17:23-29
Published Date: 7 January 2021

Clinical Features for Severely and Critically Ill Patients with COVID-19 in Shandong: A Retrospective Cohort Study
Zhou S, Xu J, Sun W, Zhang J, Zhang F, Zhao X, Wang X, Zhang W, Li Y, Ning K, Pan Y, Liu T, Zhao J, Yu J, Sun Y, Gao F, Zhang R, Fu C, Sun Y, Ouyang X, Zhang F, Hu Q, Teng H, Li Y, Zhang C, Tan W, Li J, Yin L, Dong L, Wang C
Therapeutics and Clinical Risk Management 2021, 17:9-21
Published Date: 6 January 2021

Computed Tomography Angiography of Gastrocolic Vein Trunk by Morphological Filtering Technique in Right Colon Cancer
Gu L, Wen S, Xu C, Zhu J, Liu P, Xu Q
Therapeutics and Clinical Risk Management 2021, 17:1-7
Published Date: 6 January 2021