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Journal of Hepatocellular Carcinoma
ISSN: 2253-5969
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Archive: Volume 8, 2021
Dicer Enhances Bevacizumab-Related Inhibition of Hepatocellular Carcinoma via Blocking the Vascular Endothelial Growth Factor Pathway
Wang C, Lv Y, Sha Z, Zhang J, Wu J, Qi Y, Guo Z
Journal of Hepatocellular Carcinoma 2021, 8:1643-1653
Published Date: 29 December 2021
Acyl-CoA Thioesterase 7 is Transcriptionally Activated by Krüppel-Like Factor 13 and Promotes the Progression of Hepatocellular Carcinoma
Xie X, Chen C, Feng S, Zuo S, Zhao X, Li H
Journal of Hepatocellular Carcinoma 2021, 8:1623-1641
Published Date: 23 December 2021
Key Candidate Prognostic Biomarkers Correlated with Immune Infiltration in Hepatocellular Carcinoma
Deng Z, Huang K, Liu D, Luo N, Liu T, Han L, Du D, Lian D, Zhong Z, Peng J
Journal of Hepatocellular Carcinoma 2021, 8:1607-1622
Published Date: 18 December 2021
Clinical Characteristics, Treatment Patterns, and Healthcare Costs and Utilization for Hepatocellular Carcinoma (HCC) Patients Treated at a Large Referral Center in Washington State 2007–2018
Shankaran V, Chennupati S, Sanchez H, Sun Q, Li L, Fedorenko C, Aly A, Healey M, Seal B
Journal of Hepatocellular Carcinoma 2021, 8:1597-1606
Published Date: 14 December 2021

Experimental Validation of Novel Glypican 3 Exosomes for the Detection of Hepatocellular Carcinoma in Liver Cirrhosis

Aydin Y, Koksal AR, Thevenot P, Chava S, Heidari Z, Lin D, Sandow T, Moroz K, Parsi MA, Scott J, Cohen A, Dash S
Journal of Hepatocellular Carcinoma 2021, 8:1579-1596
Published Date: 8 December 2021
Yttrium-90 Radioembolization Is Associated with Better Clinical Outcomes in Patients with Hepatocellular Carcinoma Compared with Conventional Chemoembolization: A Propensity Score-Matched Study
Kim MA, Jang H, Choi NR, Nam JY, Lee YB, Cho EJ, Lee JH, Yu SJ, Kim HC, Chung JW, Yoon JH, Kim YJ
Journal of Hepatocellular Carcinoma 2021, 8:1565-1577
Published Date: 7 December 2021

Re-Recognizing the Cellular Origin of the Primary Epithelial Tumors of the Liver
Feng J, Zhu R, Yin Y, Wang S, Zhou L, Lv F, Zhao D
Journal of Hepatocellular Carcinoma 2021, 8:1537-1563
Published Date: 7 December 2021
Donafenib-Loaded Callispheres Beads Embolization in a VX2 Liver Tumor: Investigating Efficacy, Safety, and Improvement of Tumor Angiogenesis After Embolization
Li T, Shi Q, Liu J, Wang Y, Zhou C, Wang C, Ju S, Huang S, Yang C, Chen Y, Bai Y, Xiong B
Journal of Hepatocellular Carcinoma 2021, 8:1525-1535
Published Date: 3 December 2021
Inflammatory Scores: Comparison and Utility in HCC Patients Undergoing Transarterial Chemoembolization in a North American Cohort
Young S, Cam I, Gencturk M, Rubin N, D'souza D, Flanagan S, Golzarian J, Sanghvi T
Journal of Hepatocellular Carcinoma 2021, 8:1513-1524
Published Date: 1 December 2021
PRRC2A Promotes Hepatocellular Carcinoma Progression and Associates with Immune Infiltration
Liu X, Zhang Y, Wang Z, Liu L, Zhang G, Li J, Ren Z, Dong Z, Yu Z
Journal of Hepatocellular Carcinoma 2021, 8:1495-1511
Published Date: 1 December 2021
Antibiotic Therapy is Associated with Worse Outcome in Patients with Hepatocellular Carcinoma Treated with Sorafenib
Pomej K, Balcar L, Scheiner B, Semmler G, Meischl T, Mandorfer M, Reiberger T, Müller C, Trauner M, Pinter M
Journal of Hepatocellular Carcinoma 2021, 8:1485-1493
Published Date: 30 November 2021
Prediction of Early Treatment Response to Initial Conventional Transarterial Chemoembolization Therapy for Hepatocellular Carcinoma by Machine-Learning Model Based on Computed Tomography
Dong Z, Lin Y, Lin F, Luo X, Lin Z, Zhang Y, Li L, Li ZP, Feng ST, Cai H, Peng Z
Journal of Hepatocellular Carcinoma 2021, 8:1473-1484
Published Date: 30 November 2021
Drug-Eluting Bead Transarterial Chemoembolization versus Conventional Transarterial Chemoembolization Both Combined Apatinib for Hepatocellular Carcinoma: A Retrospective, Propensity-Score Matched Study
Ouyang T, Liu J, Shi C, Zhu L, Guo X
Journal of Hepatocellular Carcinoma 2021, 8:1459-1471
Published Date: 26 November 2021
Drug-Eluting Bead Transarterial Chemoembolization Combined with FOLFOX-Based Hepatic Arterial Infusion Chemotherapy for Large or Huge Hepatocellular Carcinoma
Huang J, Huang W, Zhan M, Guo Y, Liang L, Cai M, Lin L, He M, Lian H, Lu L, Zhu K
Journal of Hepatocellular Carcinoma 2021, 8:1445-1458
Published Date: 26 November 2021

Wnt/β-Catenin Signaling as a Driver of Hepatocellular Carcinoma Progression: An Emphasis on Molecular Pathways
Deldar Abad Paskeh M, Mirzaei S, Ashrafizadeh M, Zarrabi A, Sethi G
Journal of Hepatocellular Carcinoma 2021, 8:1415-1444
Published Date: 25 November 2021
Molecular Signature and Immune Landscape of HCV-Associated Hepatocellular Carcinoma (HCC): Differences and Similarities with HBV-HCC
De Battista D, Zamboni F, Gerstein H, Sato S, Markowitz TE, Lack J, Engle RE, Farci P
Journal of Hepatocellular Carcinoma 2021, 8:1399-1413
Published Date: 21 November 2021
Role of Rab GTPases in Hepatocellular Carcinoma
Yang CC, Meng GX, Dong ZR, Li T
Journal of Hepatocellular Carcinoma 2021, 8:1389-1397
Published Date: 19 November 2021
An Optimal Ablative Margin of Small Single Hepatocellular Carcinoma Treated with Image-Guided Percutaneous Thermal Ablation and Local Recurrence Prediction Base on the Ablative Margin: A Multicenter Study
Li FY, Li JG, Wu SS, Ye HL, He XQ, Zeng QJ, Zheng RQ, An C, Li K
Journal of Hepatocellular Carcinoma 2021, 8:1375-1388
Published Date: 15 November 2021
Increased Serum Pentraxin 3 Levels are Associated with Poor Prognosis of Hepatitis B Virus-Related Hepatocellular Carcinoma
Han Q, Deng H, Fan X, Wang X, Zhang X, Zhang K, Li N, Lv Y, Liu Z
Journal of Hepatocellular Carcinoma 2021, 8:1367-1373
Published Date: 13 November 2021

Albumin-Bilirubin (ALBI) and Monocyte to Lymphocyte Ratio (MLR)-Based Nomogram Model to Predict Tumor Recurrence of AFP-Negative Hepatocellular Carcinoma
Mao S, Yu X, Shan Y, Fan R, Wu S, Lu C
Journal of Hepatocellular Carcinoma 2021, 8:1355-1365
Published Date: 12 November 2021
CircANTXR1 Contributes to the Malignant Progression of Hepatocellular Carcinoma by Promoting Proliferation and Metastasis
Huang C, Yu W, Wang Q, Huang T, Ding Y
Journal of Hepatocellular Carcinoma 2021, 8:1339-1353
Published Date: 9 November 2021
CYP2C8 Suppress Proliferation, Migration, Invasion and Sorafenib Resistance of Hepatocellular Carcinoma via PI3K/Akt/p27kip1 Axis
Zhou X, Li TM, Luo JZ, Lan CL, Wei ZL, Fu TH, Liao XW, Zhu GZ, Ye XP, Peng T
Journal of Hepatocellular Carcinoma 2021, 8:1323-1338
Published Date: 3 November 2021
Chemoembolization Plus Microwave Ablation vs Chemoembolization Alone in Unresectable Hepatocellular Carcinoma Beyond the Milan Criteria: A Propensity Scoring Matching Study
Li HZ, Tan J, Tang T, An TZ, Li JX, Xiao YD
Journal of Hepatocellular Carcinoma 2021, 8:1311-1322
Published Date: 1 November 2021
Dynamic Changes in Neutrophil-to-Lymphocyte Ratio are Associated with Survival and Liver Toxicity Following Stereotactic Body Radiotherapy for Hepatocellular Carcinoma
Hsiang CW, Huang WY, Yang JF, Shen PC, Dai YH, Wang YF, Lin CS, Chang WC, Lo CH
Journal of Hepatocellular Carcinoma 2021, 8:1299-1309
Published Date: 29 October 2021
Machine Learning to Improve Prognosis Prediction of Early Hepatocellular Carcinoma After Surgical Resection [Corrigendum]
Ji GW, Fan Y, Sun DW, Wu MY, Wang K, Li XC, Wang XH
Journal of Hepatocellular Carcinoma 2021, 8:1297-1298
Published Date: 27 October 2021
Response Stratification in the First-Line Combined Immunotherapy of Hepatocellular Carcinoma at Genomic, Transcriptional and Immune Repertoire Levels
Cheng J, Li Y, Wang X, Dong Z, Chen Y, Zhang R, Huang J, Jin X, Yao J, Ge A, Song L, Lu Y, Zeng Z
Journal of Hepatocellular Carcinoma 2021, 8:1281-1295
Published Date: 27 October 2021
Scirrhous Hepatocellular Carcinoma: Systematic Review and Pooled Data Analysis of Clinical, Radiological, and Histopathological Features
Murtha-Lemekhova A, Fuchs J, Schulz E, Sterkenburg AS, Mayer P, Pfeiffenberger J, Hoffmann K
Journal of Hepatocellular Carcinoma 2021, 8:1269-1279
Published Date: 22 October 2021
Antiviral Therapy Reduces Mortality in Hepatocellular Carcinoma Patients with Low-Level Hepatitis B Viremia
Wang X, Liu X, Wang P, Yu L, Yan F, Yan H, Zhou D, Yang Z
Journal of Hepatocellular Carcinoma 2021, 8:1253-1267
Published Date: 21 October 2021
Serum KLKB1 as a Potential Prognostic Biomarker for Hepatocellular Carcinoma Based on Data-Independent Acquisition and Parallel Reaction Monitoring
Che YQ, Zhang Y, Li HB, Shen D, Cui W
Journal of Hepatocellular Carcinoma 2021, 8:1241-1252
Published Date: 12 October 2021

Lenvatinib Combined with Anti-PD-1 Antibodies Plus Transcatheter Arterial Chemoembolization for Unresectable Hepatocellular Carcinoma: A Multicenter Retrospective Study
Wu JY, Yin ZY, Bai YN, Chen YF, Zhou SQ, Wang SJ, Zhou JY, Li YN, Qiu FN, Li B, Yan ML
Journal of Hepatocellular Carcinoma 2021, 8:1233-1240
Published Date: 5 October 2021
Intraarterial Lidocaine Administration for Pain Control by Water-in-Oil Technique in Transarterial Chemoembolization: in vivo and Randomized Clinical Trial
Wang LZ, Hu XX, Shen XC, Wang TC, Zhou S
Journal of Hepatocellular Carcinoma 2021, 8:1221-1232
Published Date: 5 October 2021
An Analysis of Individual and Contextual-Level Disparities in Screening, Treatment, and Outcomes for Hepatocellular Carcinoma
Kronenfeld JP, Goel N
Journal of Hepatocellular Carcinoma 2021, 8:1209-1219
Published Date: 28 September 2021

Current Landscape and Future Directions of Biomarkers for Immunotherapy in Hepatocellular Carcinoma
Gok Yavuz B, Hasanov E, Lee SS, Mohamed YI, Curran MA, Koay EJ, Cristini V, Kaseb AO
Journal of Hepatocellular Carcinoma 2021, 8:1195-1207
Published Date: 24 September 2021

Percutaneous Therapies for Hepatocellular Carcinoma: Evolution of Liver Directed Therapies
Huber TC, Bochnakova T, Koethe Y, Park B, Farsad K
Journal of Hepatocellular Carcinoma 2021, 8:1181-1193
Published Date: 23 September 2021
Carbon Ion Radiotherapy in the Management of Hepatocellular Carcinoma
Abousaida B, Seneviratne D, Hoppe BS, Ko SJ, Asaithamby A, Cucinotta FA, Kirwan JM, Mody K, Toskich B, Ashman JB, Hallemeier CL, Krishnan S
Journal of Hepatocellular Carcinoma 2021, 8:1169-1179
Published Date: 24 September 2021

Impact of COVID-19 on Hepatocellular Carcinoma Management: A Multicountry and Region Study
Gandhi M, Ling WH, Chen CH, Lee JH, Kudo M, Chanwat R, Strasser SI, Xu Z, Lai SH, Chow PKH
Journal of Hepatocellular Carcinoma 2021, 8:1159-1167
Published Date: 23 September 2021

Second-Line Treatment Options for Hepatocellular Carcinoma: Current Landscape and Future Direction
Pathak S, Sonbol MB
Journal of Hepatocellular Carcinoma 2021, 8:1147-1158
Published Date: 21 September 2021
A Prospective Phase II Study of Safety and Efficacy of Sorafenib Followed by 90Y Glass Microspheres for Patients with Advanced or Metastatic Hepatocellular Carcinoma
Kaseb AO, Kappadath SC, Lee SS, Raghav KP, Mohamed YI, Xiao L, Morris JS, Ohaji C, Avritscher R, Odisio BC, Kuban J, Abdelsalam ME, Chasen B, Elsayes KM, Elbanan M, Wolff RA, Yao JC, Mahvash A
Journal of Hepatocellular Carcinoma 2021, 8:1129-1145
Published Date: 9 September 2021
Primary Liver Sarcomatoid Carcinoma: A Case Series and Literature Review
Ji W, Xing Y, Ma J, Zhao Z, Xu H, Zheng S, Li W, Li X
Journal of Hepatocellular Carcinoma 2021, 8:1117-1127
Published Date: 7 September 2021

Portal Vein Tumor Thrombosis and Hepatocellular Carcinoma – The Changing Tides
Khan AR, Wei X, Xu X
Journal of Hepatocellular Carcinoma 2021, 8:1089-1115
Published Date: 7 September 2021

An Overview of the Genomic Characterization of Hepatocellular Carcinoma
Yim SY, Lee JS
Journal of Hepatocellular Carcinoma 2021, 8:1077-1088
Published Date: 7 September 2021


Deep Learning-Based Prediction of Future Extrahepatic Metastasis and Macrovascular Invasion in Hepatocellular Carcinoma
Fu S, Pan M, Zhang J, Zhang H, Tang Z, Li Y, Mu W, Huang J, Dong D, Duan C, Li X, Wang S, Chen X, He X, Yan J, Lu L, Tian J
Journal of Hepatocellular Carcinoma 2021, 8:1065-1076
Published Date: 4 September 2021
A Genetic Variant of PPP1CB Influences Risk of Hepatitis B Virus-Related Hepatocellular Carcinoma in Han Chinese: A Pathway Based Analysis
Mai H, Xie H, Hou J, Chen H, Zhou B, Hou J, Jiang D
Journal of Hepatocellular Carcinoma 2021, 8:1055-1064
Published Date: 2 September 2021

Peptide-Based Vaccines for Hepatocellular Carcinoma: A Review of Recent Advances
Charneau J, Suzuki T, Shimomura M, Fujinami N, Nakatsura T
Journal of Hepatocellular Carcinoma 2021, 8:1035-1054
Published Date: 2 September 2021

Liver Cancer Survival: A Real World Observation of 45 Years with 32,556 Cases
Chen JG, Zhu J, Zhang YH, Chen YS, Ding LL, Chen HZ, Shen AG, Wang GR
Journal of Hepatocellular Carcinoma 2021, 8:1023-1034
Published Date: 31 August 2021
Regulation Network and Prognostic Significance of Aldo-Keto Reductase (AKR) Superfamily Genes in Hepatocellular Carcinoma

Dai T, Ye L, Yu H, Li K, Li J, Liu R, Lu X, Deng M, Li R, Liu W, Yang Y, Wang G
Journal of Hepatocellular Carcinoma 2021, 8:997-1021
Published Date: 30 August 2021

Molecular Targets of Ferroptosis in Hepatocellular Carcinoma
Liao H, Shi J, Wen K, Lin J, Liu Q, Shi B, Yan Y, Xiao Z
Journal of Hepatocellular Carcinoma 2021, 8:985-996
Published Date: 24 August 2021
MR Features Based on LI-RADS Ver. 2018 Correlated with Cytokeratin 19 Expression in Combined Hepatocellular Carcinoma-Cholangiocarcinoma
Zhou C, Ni X, Lu X, Wang Y, Qian X, Yang C, Zeng M
Journal of Hepatocellular Carcinoma 2021, 8:975-983
Published Date: 21 August 2021
Concurrent Sorafenib and Radiotherapy versus Radiotherapy Alone for Locally Advanced Hepatocellular Carcinoma: A Propensity-Matched Analysis
Liu CM, Huang BS, Yen YH, Wang YM, Huang EY, Hsu HC, Huang TT, Yang YH, Cheng JY
Journal of Hepatocellular Carcinoma 2021, 8:963-973
Published Date: 18 August 2021
Fine Mapping of the MHC Region Identifies Novel Variants Associated with HBV-Related Hepatocellular Carcinoma in Han Chinese
Mai H, Chen J, Chen H, Liu Z, Huang G, Wang J, Xiao Q, Ren W, Zhou B, Hou J, Jiang D
Journal of Hepatocellular Carcinoma 2021, 8:951-961
Published Date: 16 August 2021

Transcatheter Arterial Chemoembolization with Drug-Eluting Beads for the Treatment of Hepatocellular Carcinoma: Recommended Selection for Small-Caliber (<100 μm) Beads
Chang WC, Hsu HH, Chiu SH, Huang WY, Lo CH, Lin HH, Huang PC, Shih YL, Wan YL
Journal of Hepatocellular Carcinoma 2021, 8:937-949
Published Date: 14 August 2021
Decreased Incidence of Hepatocellular Carcinoma after Directly Acting Antiviral Therapy in Patients with Hepatitis C–Related Advanced Fibrosis and Cirrhosis
Kilany S, Ata L, Gomaa A, Sabry A, Nada A, Tharwa ES, Badra G, Abogabal A, Elwaraky M, Moaz E, Ezzat S, Elsharawy A, Waked I
Journal of Hepatocellular Carcinoma 2021, 8:925-935
Published Date: 12 August 2021

Machine Learning to Improve Prognosis Prediction of Early Hepatocellular Carcinoma After Surgical Resection

Ji GW, Fan Y, Sun DW, Wu MY, Wang K, Li XC, Wang XH
Journal of Hepatocellular Carcinoma 2021, 8:913-923
Published Date: 10 August 2021
SLC39A10 Upregulation Predicts Poor Prognosis, Promotes Proliferation and Migration, and Correlates with Immune Infiltration in Hepatocellular Carcinoma
Ma Z, Li Z, Wang S, Zhou Q, Ma Z, Liu C, Huang B, Zheng Z, Yang L, Zou Y, Zhang C, Huang S, Hou B
Journal of Hepatocellular Carcinoma 2021, 8:899-912
Published Date: 7 August 2021

PD-1 Blockade for Hepatocellular Carcinoma: Current Research and Future Prospects
D'Alessio A, Rimassa L, Cortellini A, Pinato DJ
Journal of Hepatocellular Carcinoma 2021, 8:887-897
Published Date: 5 August 2021
DTYMK Expression Predicts Prognosis and Chemotherapeutic Response and Correlates with Immune Infiltration in Hepatocellular Carcinoma
Guo Y, Luo W, Huang S, Zhao W, Chen H, Ma Y, Ye M, Nie Y, Zhang Y, Huang C, Zhou Q, He X, Chen M
Journal of Hepatocellular Carcinoma 2021, 8:871-885
Published Date: 3 August 2021

Biochemical Safety of Ablative Yttrium-90 Radioembolization for Hepatocellular Carcinoma as a Function of Percent Liver Treated
De la Garza-Ramos C, Overfield CJ, Montazeri SA, Liou H, Paz-Fumagalli R, Frey GT, McKinney JM, Ritchie CA, Devcic Z, Lewis AR, Harnois DM, Patel T, Toskich BB
Journal of Hepatocellular Carcinoma 2021, 8:861-870
Published Date: 30 July 2021
Challenging the Treatment Paradigm: Selecting Patients for Surgical Management of Hepatocellular Carcinoma with Portal Vein Tumor Thrombus
Nevarez NM, Yopp AC
Journal of Hepatocellular Carcinoma 2021, 8:851-860
Published Date: 28 July 2021
Using the aMAP Risk Score to Predict Late Recurrence Following Radiofrequency Ablation for Hepatocellular Carcinoma in Chinese Population: A Multicenter Study
Yang Y, Zhou Y, Zhang X, Xin Y, Chen Y, Fan Q, Li X, Wei X, Li Q, Zhou X, Zhou J
Journal of Hepatocellular Carcinoma 2021, 8:837-850
Published Date: 28 July 2021
DNA and RNA Sequencing Recapitulated Aberrant Tumor Metabolism in Liver Cancer Cell Lines
Sun Y, Tang X, Ye B, Ding K
Journal of Hepatocellular Carcinoma 2021, 8:823-836
Published Date: 27 July 2021


An Exploratory Study for the Association of Gut Microbiome with Efficacy of Immune Checkpoint Inhibitor in Patients with Hepatocellular Carcinoma
Shen YC, Lee PC, Kuo YL, Wu WK, Chen CC, Lei CH, Yeh CP, Hsu C, Hsu CH, Lin ZZ, Shao YY, Lu LC, Liu TH, Chen CH, Wu MS, Huang YH, Cheng AL
Journal of Hepatocellular Carcinoma 2021, 8:809-822
Published Date: 24 July 2021

Preoperative Prediction of Cytokeratin 19 Expression for Hepatocellular Carcinoma with Deep Learning Radiomics Based on Gadoxetic Acid-Enhanced Magnetic Resonance Imaging
Chen Y, Chen J, Zhang Y, Lin Z, Wang M, Huang L, Huang M, Tang M, Zhou X, Peng Z, Huang B, Feng ST
Journal of Hepatocellular Carcinoma 2021, 8:795-808
Published Date: 22 July 2021
Construction and Validation of a Nomogram for Predicting the Risk of Deep Vein Thrombosis in Hepatocellular Carcinoma Patients After Laparoscopic Hepatectomy: A Retrospective Study
Chen Y, Zhao J, Zhang Z, Ding Z, Chen Y, Chen X, Zhang W
Journal of Hepatocellular Carcinoma 2021, 8:783-794
Published Date: 21 July 2021
Prediction of Hepatocellular Carcinoma Response to Transcatheter Arterial Chemoembolization: A Real-World Study Based on Non-Contrast Computed Tomography Radiomics and General Image Features
Guo Z, Zhong N, Xu X, Zhang Y, Luo X, Zhu H, Zhang X, Wu D, Qiu Y, Tu F
Journal of Hepatocellular Carcinoma 2021, 8:773-782
Published Date: 9 July 2021
SERPINA11 Inhibits Metastasis in Hepatocellular Carcinoma by Suppressing MEK/ERK Signaling Pathway
Song Y, Li Z, Li L, Zhou H, Zeng TT, Jin C, Lin JR, Gao S, Li Y, Guan XY, Zhu YH
Journal of Hepatocellular Carcinoma 2021, 8:759-771
Published Date: 6 July 2021


Elucidating the Molecular Basis of Sorafenib Resistance in HCC: Current Findings and Future Directions
Fornari F, Giovannini C, Piscaglia F, Gramantieri L
Journal of Hepatocellular Carcinoma 2021, 8:741-757
Published Date: 2 July 2021
Predicting Hepatocellular Carcinoma Risk in Patients with Chronic HCV Infection and a Sustained Virological Response to Direct-Acting Antivirals
D'Ambrosio R, Degasperi E, Lampertico P
Journal of Hepatocellular Carcinoma 2021, 8:713-739
Published Date: 29 June 2021
Outcomes in the Era of Interferon-Free Direct-Acting Antiviral Therapy After Liver Transplantation in Patients with Hepatitis C Virus and Hepatocellular Carcinoma
Ismail MS, Mohamed I, Polychronopoulou E, Goss JA, Kuo YF, Kanwal F, Jalal PK
Journal of Hepatocellular Carcinoma 2021, 8:701-711
Published Date: 29 June 2021
Inhibition of SIRT1 Limits Self-Renewal and Oncogenesis by Inducing Senescence of Liver Cancer Stem Cells
Wang MJ, Chen JJ, Song SH, Su J, Zhao LH, Liu QG, Yang T, Chen Z, Liu C, Fu ZR, Hu YP, Chen F
Journal of Hepatocellular Carcinoma 2021, 8:685-699
Published Date: 29 June 2021

A Semi-Automatic Step-by-Step Expert-Guided LI-RADS Grading System Based on Gadoxetic Acid-Enhanced MRI
Sheng R, Huang J, Zhang W, Jin K, Yang L, Chong H, Fan J, Zhou J, Wu D, Zeng M
Journal of Hepatocellular Carcinoma 2021, 8:671-683
Published Date: 29 June 2021
Prognostic Values of Alpha-Fetoprotein and Des-Gamma-Carboxyprothrombin in Hepatocellular Carcinoma in China: An Analysis of 4792 Patients
Pan YX, Sun XQ, Hu ZL, Xie W, Nie KX, Fang AP, Zhang YY, Fu YZ, Chen JB, Wang JC, Wang X, Zhang YJ, Hu DD, Chen MS
Journal of Hepatocellular Carcinoma 2021, 8:657-670
Published Date: 25 June 2021
An Optimized Integrin α6-Targeted Magnetic Resonance Probe for Molecular Imaging of Hepatocellular Carcinoma in Mice

Lin BQ, Zhang WB, Zhao J, Zhou XH, Li YJ, Deng J, Zhao Q, Fu G, Xie CM, Xu YK, Feng GK
Journal of Hepatocellular Carcinoma 2021, 8:645-656
Published Date: 24 June 2021

Challenges Facing Percutaneous Ablation in the Treatment of Hepatocellular Carcinoma: Extension of Ablation Criteria
Zhou Y, Yang Y, Zhou B, Wang Z, Zhu R, Chen X, Ouyang J, Li Q, Zhou J
Journal of Hepatocellular Carcinoma 2021, 8:625-644
Published Date: 21 June 2021
Clinical Characteristics of Long-Term Survivors After Sorafenib Treatment for Unresectable Hepatocellular Carcinoma: A Korean National Multicenter Retrospective Cohort Study
Cho YY, Yu SJ, Lee HW, Kim DY, Kang W, Paik YH, Sung PS, Bae SH, Park SC, Doh YS, Kim KM, Jang ES, Kim IH, Kim W, Kim YJ
Journal of Hepatocellular Carcinoma 2021, 8:613-623
Published Date: 18 June 2021
Blocking the CCL5–CCR5 Axis Using Maraviroc Promotes M1 Polarization of Macrophages Cocultured with Irradiated Hepatoma Cells
Zhuang Y, Zhao X, Yuan B, Zeng ZC, Chen Y
Journal of Hepatocellular Carcinoma 2021, 8:599-611
Published Date: 18 June 2021
Effectiveness of Transarterial Chemoembolization-First Treatment for Advanced Hepatocellular Carcinoma: A Propensity Score Matching Analysis
Chung SW, Park MK, Cho YY, Park Y, Lee CH, Oh H, Jang H, Kim MA, Kim SW, Nam JY, Lee YB, Cho EJ, Yu SJ, Kim HC, Kim YJ, Chung JW, Yoon JH, Lee JH
Journal of Hepatocellular Carcinoma 2021, 8:587-598
Published Date: 15 June 2021
Current Understanding of Ablative Radiation Therapy in Hepatocellular Carcinoma
Mathew AS, Dawson LA
Journal of Hepatocellular Carcinoma 2021, 8:575-586
Published Date: 14 June 2021
Rates of Hepatocellular Carcinoma After Start of Treatment for Chronic Hepatitis C Remain High with Direct Acting Antivirals: Analysis from a Swiss Liver Transplant Center
Karbeyaz F, Kissling S, Jaklin PJ, Bachofner J, Brunner B, Müllhaupt B, Winder T, Mertens JC, Misselwitz B, von Felten S, Siebenhüner AR
Journal of Hepatocellular Carcinoma 2021, 8:565-574
Published Date: 11 June 2021
Peritumoral Dilation Radiomics of Gadoxetate Disodium-Enhanced MRI Excellently Predicts Early Recurrence of Hepatocellular Carcinoma without Macrovascular Invasion After Hepatectomy
Chong H, Gong Y, Pan X, Liu A, Chen L, Yang C, Zeng M
Journal of Hepatocellular Carcinoma 2021, 8:545-563
Published Date: 9 June 2021

The Combination Immunotherapy of TLR9 Agonist and OX40 Agonist via Intratumoural Injection for Hepatocellular Carcinoma
Zhou Z, Lin L, An Y, Zhan M, Chen Y, Cai M, Zhu X, Lu L, Zhu K
Journal of Hepatocellular Carcinoma 2021, 8:529-543
Published Date: 8 June 2021

Up-to-Date Role of CT/MRI LI-RADS in Hepatocellular Carcinoma
Moura Cunha G, Chernyak V, Fowler KJ, Sirlin CB
Journal of Hepatocellular Carcinoma 2021, 8:513-527
Published Date: 31 May 2021
Clinical Indicators for Long-Term Survival with Immune Checkpoint Therapy in Advanced Hepatocellular Carcinoma
Monge C, Xie C, Steinberg SM, Greten TF
Journal of Hepatocellular Carcinoma 2021, 8:507-512
Published Date: 31 May 2021
Prognostic Model for the Risk Stratification of Early and Late Recurrence in Hepatitis B Virus-Related Small Hepatocellular Carcinoma Patients with Global Histone Modifications
Duan JL, Nie RC, Xiang ZC, Chen JW, Deng MH, Liang H, Wang FW, Luo RZ, Xie D, Cai MY
Journal of Hepatocellular Carcinoma 2021, 8:493-505
Published Date: 28 May 2021
Regorafenib Combined with Other Systemic Therapies: Exploring Promising Therapeutic Combinations in HCC
Granito A, Marinelli S, Forgione A, Renzulli M, Benevento F, Piscaglia F, Tovoli F
Journal of Hepatocellular Carcinoma 2021, 8:477-492
Published Date: 26 May 2021
The Prognostic Role of On-Treatment Liver Stiffness for Hepatocellular Carcinoma Development in Patients with Chronic Hepatitis B
Lee HW, Lee HW, Lee JS, Roh YH, Lee H, Kim SU, Park JY, Kim DY, Ahn SH, Kim BK
Journal of Hepatocellular Carcinoma 2021, 8:467-476
Published Date: 25 May 2021

The Crosstalk Between Cancer Cells and Neutrophils Enhances Hepatocellular Carcinoma Metastasis via Neutrophil Extracellular Traps-Associated Cathepsin G Component: A Potential Therapeutic Target
Guan X, Lu Y, Zhu H, Yu S, Zhao W, Chi X, Xie C, Yin Z
Journal of Hepatocellular Carcinoma 2021, 8:451-465
Published Date: 20 May 2021

The Mechanisms of HBV-Induced Hepatocellular Carcinoma
Jiang Y, Han Q, Zhao H, Zhang J
Journal of Hepatocellular Carcinoma 2021, 8:435-450
Published Date: 20 May 2021

Phase I Trial on Arterial Embolization with Hypoxia Activated Tirapazamine for Unresectable Hepatocellular Carcinoma


Abi-Jaoudeh N, Dayyani F, Chen PJ, Fernando D, Fidelman N, Javan H, Liang PC, Hwang JI, Imagawa DK
Journal of Hepatocellular Carcinoma 2021, 8:421-434
Published Date: 17 May 2021

Current Strategies to Identify Patients That Will Benefit from TACE Treatment and Future Directions a Practical Step-by-Step Guide
Müller L, Stoehr F, Mähringer-Kunz A, Hahn F, Weinmann A, Kloeckner R
Journal of Hepatocellular Carcinoma 2021, 8:403-419
Published Date: 13 May 2021

Hepatocellular Carcinoma: An Overview of the Changing Landscape of Treatment Options
Koulouris A, Tsagkaris C, Spyrou V, Pappa E, Troullinou A, Nikolaou M
Journal of Hepatocellular Carcinoma 2021, 8:387-401
Published Date: 13 May 2021


MicroRNAs as Modulators of Tumor Metabolism, Microenvironment, and Immune Response in Hepatocellular Carcinoma
Gramantieri L, Giovannini C, Piscaglia F, Fornari F
Journal of Hepatocellular Carcinoma 2021, 8:369-385
Published Date: 12 May 2021
Clinical, Pathological and Genetic Characteristics of Pediatric Hepatocellular Carcinoma Associated with Hepatitis B Virus Infection
Zhao P, Lu Y, Wang C, Wang L, Li J, Li M
Journal of Hepatocellular Carcinoma 2021, 8:361-367
Published Date: 10 May 2021
Texture Analysis Based on Gd-EOB-DTPA-Enhanced MRI for Identifying Vessels Encapsulating Tumor Clusters (VETC)-Positive Hepatocellular Carcinoma
Fan Y, Yu Y, Wang X, Hu M, Du M, Guo L, Sun S, Hu C
Journal of Hepatocellular Carcinoma 2021, 8:349-359
Published Date: 5 May 2021
LncRNA-CCDC144NL-AS1 Promotes the Development of Hepatocellular Carcinoma by Inducing WDR5 Expression via Sponging miR-940
Zhang Y, Zhang H, Wu S
Journal of Hepatocellular Carcinoma 2021, 8:333-348
Published Date: 3 May 2021
Current Status of Therapeutic Choice and Feasibility for Patients with Hepatocellular Carcinoma Aged ≥ 70 Years: A Nationwide Cancer Registry Analysis
Rho SY, Lee HW, Kim DY, Kim KS
Journal of Hepatocellular Carcinoma 2021, 8:321-332
Published Date: 30 April 2021
Impact of Sarcopenia on Two-Year Mortality in Patients with HCV-Associated Hepatocellular Carcinoma After Radiofrequency Ablation
Salman A, Salman M, Moustafa A, Shaaban HE, El-Mikkawy A, Labib S, Youssef A, Omar MG, Matter M, Elkassar H
Journal of Hepatocellular Carcinoma 2021, 8:313-320
Published Date: 29 April 2021
Development of Prognostic Evaluation Model to Predict the Overall Survival and Early Recurrence of Hepatocellular Carcinoma
Zhong Y, Yang Y, He L, Zhou Y, Cheng N, Chen G, Zhao B, Wang Y, Wang G, Liu X
Journal of Hepatocellular Carcinoma 2021, 8:301-312
Published Date: 29 April 2021
Serum Levels of ITGBL1 as an Early Diagnostic Biomarker for Hepatocellular Carcinoma with Hepatitis B Virus Infection
Ye F, Huang W, Xue Y, Tang E, Wang M, Shi F, Wei D, Han Y, Chen P, Zhang X, Yu D
Journal of Hepatocellular Carcinoma 2021, 8:285-300
Published Date: 27 April 2021
ARHGAP20 Expression Inhibited HCC Progression by Regulating the PI3K-AKT Signaling Pathway
Liu G, Li J, Zhang CY, Huang DY, Xu JW
Journal of Hepatocellular Carcinoma 2021, 8:271-284
Published Date: 21 April 2021
Ultrasound-Guided Percutaneous Ethanol-Paclitaxel Combined Therapy for Rabbit VX2 Liver Tumors
Chen L, Liu ZX, Bi QC, Zhao J, Liang QR, Tang Q
Journal of Hepatocellular Carcinoma 2021, 8:263-270
Published Date: 20 April 2021
Selecting an Optimal Staging System for Intermediate-Stage Hepatocellular Carcinoma: Comparison of 9 Currently Used Prognostic Models
Zhang YF, Shi M, Lu LH, Wang L, Guo RP
Journal of Hepatocellular Carcinoma 2021, 8:253-261
Published Date: 19 April 2021

A Comparison of Lenvatinib versus Sorafenib in the First-Line Treatment of Unresectable Hepatocellular Carcinoma: Selection Criteria to Guide Physician’s Choice in a New Therapeutic Scenario
Dipasquale A, Marinello A, Santoro A
Journal of Hepatocellular Carcinoma 2021, 8:241-251
Published Date: 15 April 2021

NAFLD-Associated HCC: Progress and Opportunities
Geh D, Anstee QM, Reeves HL
Journal of Hepatocellular Carcinoma 2021, 8:223-239
Published Date: 8 April 2021
High Expression of PIGC Predicts Unfavorable Survival in Hepatocellular Carcinoma
Guo X, Tian S, Cao P, Xie Y, Dong W
Journal of Hepatocellular Carcinoma 2021, 8:211-222
Published Date: 6 April 2021

Development and Validation of a Metabolic Gene-Based Prognostic Signature for Hepatocellular Carcinoma
Weng J, Zhou C, Zhou Q, Chen W, Yin Y, Atyah M, Dong Q, Shi Y, Ren N
Journal of Hepatocellular Carcinoma 2021, 8:193-209
Published Date: 29 March 2021

The Role of Cabozantinib as a Therapeutic Option for Hepatocellular Carcinoma: Current Landscape and Future Challenges
D'Alessio A, Prete MG, Cammarota A, Personeni N, Rimassa L
Journal of Hepatocellular Carcinoma 2021, 8:177-191
Published Date: 29 March 2021
Anti-PD-1 Immunotherapy Improves the Efficacy of Hepatic Artery Infusion Chemotherapy in Advanced Hepatocellular Carcinoma
Mei J, Li SH, Li QJ, Sun XQ, Lu LH, Lin WP, Zheng L, Chen MS, Shi M, Wei W, Guo RP
Journal of Hepatocellular Carcinoma 2021, 8:167-176
Published Date: 25 March 2021

Short- and Long-Term Outcomes After Hepatectomy in Elderly Patients with Hepatocellular Carcinoma: An Analysis of 229 Cases from a Developing Country
Galun D, Bogdanovic A, Zivanovic M, Zuvela M
Journal of Hepatocellular Carcinoma 2021, 8:155-165
Published Date: 23 March 2021

Comparison of Efficacy of Systemic Therapies in Advanced Hepatocellular Carcinoma: Updated Systematic Review and Frequentist Network Meta-Analysis of Randomized Controlled Trials
Park R, Lopes da Silva L, Nissaisorakarn V, Riano I, Williamson S, Sun W, Saeed A
Journal of Hepatocellular Carcinoma 2021, 8:145-154
Published Date: 22 March 2021
Recurrence of Hepatocellular Carcinoma After Liver Transplantation is Associated with Episodes of Acute Rejections
Gül-Klein S, Kästner A, Haber PK, Krenzien F, Wabitsch S, Krannich A, Andreou A, Eurich D, Tacke F, Horst D, Pratschke J, Schmelzle M
Journal of Hepatocellular Carcinoma 2021, 8:133-143
Published Date: 18 March 2021
A Novel Metabolism-Related Signature as a Candidate Prognostic Biomarker for Hepatocellular Carcinoma
Wang Z, Embaye KS, Yang Q, Qin L, Zhang C, Liu L, Zhan X, Zhang F, Wang X, Qin S
Journal of Hepatocellular Carcinoma 2021, 8:119-132
Published Date: 16 March 2021

Association of Postoperative Biomarker Response with Recurrence and Survival in Patients with Hepatocellular Carcinoma and High Alpha-Fetoprotein Expressions (>400 ng/ml)
Liang L, Wang MD, Zhang YM, Zhang WG, Zhang CW, Lau WY, Shen F, Pawlik TM, Huang DS, Yang T
Journal of Hepatocellular Carcinoma 2021, 8:103-118
Published Date: 12 March 2021
Gene Expression Profile and Prognostic Value of m6A RNA Methylation Regulators in Hepatocellular Carcinoma
Chang X, Lv YF, He J, Cao Y, Li CQ, Guo QN
Journal of Hepatocellular Carcinoma 2021, 8:85-101
Published Date: 12 March 2021
Imaging, Pathology, and Immune Correlates in the Woodchuck Hepatic Tumor Model
Mauda-Havakuk M, Mikhail AS, Starost MF, Jones EC, Karim B, Kleiner DE, Partanen A, Esparza-Trujillo JA, Bakhutashvili I, Wakim PG, Kassin MT, Lewis AL, Karanian JW, Wood BJ, Pritchard WF
Journal of Hepatocellular Carcinoma 2021, 8:71-83
Published Date: 9 March 2021

Radiation-Associated Lymphopenia and Outcomes of Patients with Unresectable Hepatocellular Carcinoma Treated with Radiotherapy
De B, Ng SP, Liu AY, Avila S, Tao R, Holliday EB, Brownlee Z, Kaseb A, Lee S, Raghav K, Vauthey JN, Minsky BD, Herman JM, Das P, Smith GL, Taniguchi CM, Krishnan S, Crane CH, Grassberger C, Hong TS, Lin SH, Koong AC, Mohan R, Koay EJ
Journal of Hepatocellular Carcinoma 2021, 8:57-69
Published Date: 3 March 2021
Mechanisms Underlying Hepatocellular Carcinoma Progression in Patients with Type 2 Diabetes
Shi T, Kobara H, Oura K, Masaki T
Journal of Hepatocellular Carcinoma 2021, 8:45-55
Published Date: 11 February 2021
Efficacy of Local Therapy for Oligometastatic Hepatocellular Carcinoma: A Propensity Score Matched Analysis
Kim K, Kim TH, Kim TH, Seong J
Journal of Hepatocellular Carcinoma 2021, 8:35-44
Published Date: 11 February 2021
The Significance of Gamma-Glutamyl Transpeptidase to Lymphocyte Count Ratio in the Early Postoperative Recurrence Monitoring and Prognosis Prediction of AFP-Negative Hepatocellular Carcinoma
Li S, Xu W, Liao M, Zhou Y, Weng J, Ren L, Yu J, Liao W, Huang Z
Journal of Hepatocellular Carcinoma 2021, 8:23-33
Published Date: 9 February 2021
Targeting De Novo Lipogenesis and Cholesterol Biosynthesis Simultaneously is a Novel Therapeutic Option for Hepatocellular Carcinoma
Liu Q, Dong X
Journal of Hepatocellular Carcinoma 2021, 8:19-21
Published Date: 28 January 2021
Recent Update on the Role of Circular RNAs in Hepatocellular Carcinoma
Ely A, Bloom K, Maepa MB, Arbuthnot P
Journal of Hepatocellular Carcinoma 2021, 8:1-17
Published Date: 27 January 2021