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Journal of Hepatocellular Carcinoma

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ISSN: 2253-5969

Journal Articles:

- 1,084 records -

Original Research

Prognostic Relevance of Neddylation-Related Genes in Hepatocellular Carcinoma

Sun Q, Tan G

Journal of Hepatocellular Carcinoma 2026, 13:610030

Published Date: 11 July 2026

Original Research

SNHG6 Promotes Lipid Metabolic Reprogramming in Hepatocellular Carcinoma via Upregulation of SCD

Zheng X, Lu J, Qiu H, Jin Q, Cao L, Liu J, Song P, Yao S

Journal of Hepatocellular Carcinoma 2026, 13:610313

Published Date: 10 July 2026

Original Research

Tumor Burden Thresholds Associated with Successful Downstaging After Yttrium-90 Radioembolization in Hepatocellular Carcinoma Beyond UCSF Criteria

Chiu CH, Yu CY, Ou HY, Tsang LC, Huang PH, Weng CC, Lu Y, Chen CL, Cheng YF

Journal of Hepatocellular Carcinoma 2026, 13:613375

Published Date: 10 July 2026

Original Research

Efficacy and Safety of Modified Sishen Decoction for Tyrosine Kinase Inhibitor-Induced Diarrhea in Hepatocellular Carcinoma: A Randomized Controlled Trial

Cao J, He S, Yu S, Shen J, Hu N, Yu D, Cao T, Jiang L, Peng J, Zhai X

Journal of Hepatocellular Carcinoma 2026, 13:608479

Published Date: 9 July 2026

Original Research

Correlation of Insulin and/or Insulin Secretagogues with the Risk of Hepatocellular Carcinoma and All-Cause Mortality Among Patients with Chronic Hepatitis B and Type 2 Diabetes Mellitus: A Retrospective Cohort Study

Zhou M, Zhou P, Xu W, Zhu D, Zhang F, Li W, Ye C

Journal of Hepatocellular Carcinoma 2026, 13:611091

Published Date: 9 July 2026

Original Research

SPP1+ Macrophages Promote Immunosuppression in Post-TACE Hepatocellular Carcinoma Involving Lactate-Induced Lactylation and Potential SPP1-CD44 Signaling

Wang H, Liang G, Liu T, He M, Jiang Y, Li J, Ouyang Y, Hao S, Liu W, Li J

Journal of Hepatocellular Carcinoma 2026, 13:603485

Published Date: 8 July 2026

Review

Etiology-Driven Mouse Models of Hepatocellular Carcinoma: Paving the Way for Precision Oncology

Cao W, Fan Y, Chen H, Sun J, Jin X

Journal of Hepatocellular Carcinoma 2026, 13:621043

Published Date: 8 July 2026

Original Research

Preoperative Prediction of Glypican-3 Expression in Hepatocellular Carcinoma Using Sonazoid Contrast-Enhanced Ultrasound Radiomics

Yang S, Huang Z, Zheng W, Li L, Xue Y, Zou R, Peng C

Journal of Hepatocellular Carcinoma 2026, 13:610969

Published Date: 30 June 2026

Original Research

Baseline Sleep Quality and Objective Response in HCC Patients Treated with TACE Combined with Lenvatinib and PD-1 Inhibitors: A Secondary Analysis of a Prospectively Registered Observational Cohort

Tian P, Zhao H, Sun W, Peng Q, Luo Y, Sang M, Xi J, Song HY, Yang Z

Journal of Hepatocellular Carcinoma 2026, 13:600627

Published Date: 29 June 2026

Review

Emerging Role of Sirtuins-Mediated Ferroptosis in Hepatocellular Carcinoma Progression: Mechanisms and Therapeutic Perspectives

Bai J, Bai X, Yang J, Yu G, Cui Y

Journal of Hepatocellular Carcinoma 2026, 13:595693

Published Date: 29 June 2026

Original Research

Machine-Learning Based Prognostic Model for Predicting Early Recurrence in HCC Patients After Hepatectomies: An Explainable AI Approach

Hsu HY, Lin JC, Huang CW, Huang SF, Wu CY, Huang TS, Lai HF, Yu MC

Journal of Hepatocellular Carcinoma 2026, 13:618264

Published Date: 24 June 2026

Original Research

Angiogenic Prognostic Signature for Stratification in Hepatocellular Carcinoma

Zhu Z, Guo C, Shen H, Zeng S, Li N

Journal of Hepatocellular Carcinoma 2026, 13:600117

Published Date: 20 June 2026

Original Research

Multimodal Modeling Distinguishes Treatment Response from Overall Survival in Hepatocellular Carcinoma Receiving Combined Interventional and Targeted Immunotherapy

Lu D, Sun P, Li H, Liang Z, Zhang Z, Cao Q, Zhang D, He Q, Jia J, Wang Y, Dong Z, Wang D, Li T

Journal of Hepatocellular Carcinoma 2026, 13:613014

Published Date: 20 June 2026

Review

Integrating Combination Therapy and Smart Embolic Materials to Overcome the Therapeutic Ceiling of Transarterial Chemoembolization in Hepatocellular Carcinoma

Fu Y, Bai C, Ling Y, Liu Y, Li W, Li G

Journal of Hepatocellular Carcinoma 2026, 13:620956

Published Date: 19 June 2026

Original Research

Current Status and Emerging Trends in Global Research on Liposome Therapy for Hepatocellular Carcinoma: A Bibliometric Analysis

Hong X, Wu Y, Wu X, Huang C, Li C

Journal of Hepatocellular Carcinoma 2026, 13:608648

Published Date: 19 June 2026

Original Research

Machine Learning-Based Radiopatho-Clinical Model Integrating Ultrasound Radiomics and Kleiner Score for Prognosis Prediction in NAFLD-Related Hepatocellular Carcinoma

Li CL, Jia Z, Yao ZY, Cui XT, Sun A, Hao AY, Chen ZY, Chen F, Cao JY, Wang ZS

Journal of Hepatocellular Carcinoma 2026, 13:611041

Published Date: 19 June 2026

Original Research

A Machine Learning Guided System for Therapeutic Decision-Making in Intra-Arterial Therapy of Hepatocellular Carcinoma

Tan L, Fan R, Zhang J, Fan H, Wu S, Li W

Journal of Hepatocellular Carcinoma 2026, 13:613199

Published Date: 18 June 2026

Original Research

Putative Imprinting Control Regions with Aberrant Blood-Based DNA Methylation are Associated with Hepatocellular Carcinoma Risk

DiFrank AJ, Corliss BA, Park JJH, Rogers M, Skaar DA, Jima DD, Cowley M, Murphy SK, Liu A, Moylan CA, Hoyo C

Journal of Hepatocellular Carcinoma 2026, 13:605131

Published Date: 18 June 2026

Review

Hepatocellular Carcinoma Precursor Lesions: From Pathological Basis to Risk Stratification and Precision Intervention

Yan R, Zhang H, Jiao J, Huang Q, Wang N, Bao J, Li X, Yan S, Li J

Journal of Hepatocellular Carcinoma 2026, 13:613101

Published Date: 18 June 2026

Original Research

TACE Combined with Ralox-HAIC (Oxaliplatin Puls Raltitrexed) and System Therapy in Patients with Unresectable Hepatocellular Carcinoma

Liu R, Cao G, Li L, Liu J, Cao H, Xing M, Feng Y, Li Z, Wang B

Journal of Hepatocellular Carcinoma 2026, 13:609273

Published Date: 18 June 2026

Original Research

Intratumoral Fibrosis is a Potential Biomarker in Patients with Hepatocellular Carcinoma Undergoing Liver Resection

Deng QY, Wang TC, Ye K

Journal of Hepatocellular Carcinoma 2026, 13:608858

Published Date: 18 June 2026

Original Research

Near-Infrared Fluorescent Probes Targeting LAG-3 for Guiding Immunomodulation and Efficacy Monitoring of Stereotactic Body Radiotherapy in Liver Cancer

Lu Q, Zeng P, An Y, Qin Y, Zhang J, Xu M, Wang C, Wu M, Chen R

Journal of Hepatocellular Carcinoma 2026, 13:584426

Published Date: 17 June 2026

Original Research

Prognostic Value of the SEA Score in Double-Negative DCP/AFP Unresectable HCC with Triple Therapy

Lin H, Ran F, Wu J, Huang C, Wu J, Liu C, Wang X, Ya H, Jiang K, Gu J, Yan M, Li S

Journal of Hepatocellular Carcinoma 2026, 13:606282

Published Date: 16 June 2026

Original Research

A Novel Predictive Model Based on Glutathione Metabolism Genes RRM2 and G6PD in Hepatocellular Carcinoma

Li X, Tang J, Qin H, Huang Y, Li M, Yang Z, Meng J, Li L

Journal of Hepatocellular Carcinoma 2026, 13:529380

Published Date: 16 June 2026

Original Research

Development and Validation of a Machine Learning-Based Individualized Model to Predict TKI Benefit in Postoperative Recurrent HCC

Li M, Jiang Y, Gong L, Sun R, Hao A, Liu K, Luan K, Jia Z, Zhang S, Liu K, Tan B, Hu W, Qu C, Cao J

Journal of Hepatocellular Carcinoma 2026, 13:599142

Published Date: 16 June 2026

Review

Tumor-Associated Macrophages in Hepatocellular Carcinoma: From Ontogeny and Heterogeneity to Immune Evasion and Therapeutic Targeting

Su Y, Liang Y, Zhong D, Chen Y, Ma SS, Huang X

Journal of Hepatocellular Carcinoma 2026, 13:616101

Published Date: 16 June 2026

Original Research

Subgroup-Specific Nomogram for Refined Risk Stratification in Hepatocellular Carcinoma Patients with Low LDL-C

Liu B, Gu Z, Li L, Li L, Jin R, Hu C

Journal of Hepatocellular Carcinoma 2026, 13:616354

Published Date: 15 June 2026

Original Research

Comparative Performance of Stereotactic Body Radiotherapy and Lenvatinib in Unresectable Hepatocellular Carcinoma Complicated by Portal Vein Tumor Thrombosis: A Propensity Score-Matched Cohort Analysis

Huang J, Liu FC, Yang Y, Yuan SX, Gu FM, Jiang BG, Pan ZY

Journal of Hepatocellular Carcinoma 2026, 13:589137

Published Date: 15 June 2026

Original Research

Aberrant Cholesterol Metabolism Caused by Decreased Lecithin: Cholesterol Acyltransferase Promoted Hepatocarcinogenesis

Gao H, Peng X, Wen Y, Gou L, Xu Y, Qu X, Wu J, Xue B

Journal of Hepatocellular Carcinoma 2026, 13:562838

Published Date: 15 June 2026

Original Research

Transarterial Chemoembolization in Hepatocellular Carcinoma: Lessons from a 10-Year Real-World Retrospective Study

von Schoen-Angerer G, Pesola G, Garo ML, Marini G, Cappio S, Cerny A, Magenta L, Majno-Hurst P, Bernardi L, Cefalì M, Cristaudi A, Terziroli Beretta-Piccoli B, Trevisi E, De Dosso S

Journal of Hepatocellular Carcinoma 2026, 13:598858

Published Date: 15 June 2026

Original Research

Optimizing Hepatocellular Carcinoma Selection for Liver Transplantation: The Impact of an Integrated MELD-ALBI Score on Post-Transplant Outcomes

Alkhatib A, Gomaa AI, Abdel-Razek W

Journal of Hepatocellular Carcinoma 2026, 13:614920

Published Date: 12 June 2026

Original Research

Development and Validation of a Nomogram Predictive Model for Massive Ascites After Hepatectomy in Patients with Primary Hepatocellular Carcinoma

Men A, Sun D, Sun X, Jin L, Liu B, Chen F, Nan B, Wang W, Han L, Zhang W

Journal of Hepatocellular Carcinoma 2026, 13:610812

Published Date: 11 June 2026

Original Research

Low Tumor miR-369-3p Levels Combined with Plasma Hepatitis B Virus Pre-S2 Gene Deletion Mutation Predict Higher Hepatocellular Carcinoma Recurrence

Wu YC, Jeng LB, Li TC, Wang J, Teng CF

Journal of Hepatocellular Carcinoma 2026, 13:591511

Published Date: 10 June 2026

Original Research

Comparable Long-Term Survival After Curative Hepatectomy for Solitary Large (5–10 cm) versus Giant (≥10 cm) Hepatocellular Carcinoma: A Retrospective Study

Jiang K, Li J, Zhang D, Wang W, Chang J

Journal of Hepatocellular Carcinoma 2026, 13:607722

Published Date: 8 June 2026

Original Research

Post-Treatment Prognostic Nutritional Index Outperforms Baseline Index as an Independent Prognostic Biomarker in Advanced Hepatocellular Carcinoma Receiving Immune-Based Systemic Therapy

Chen X, Guo X, Wang M, Chen G, Zheng S, Chen H, Zhang Z, Zhang B

Journal of Hepatocellular Carcinoma 2026, 13:606554

Published Date: 8 June 2026

Original Research

Impact of Microwave Ablation on Growth Kinetics of Residual versus Synchronous Untreated Hepatocellular Carcinoma: A Retrospective Cohort Study

Yi W, Pang C, Xue J, Zhang Y, Chen X, Luo T, Zhang D, Gao X, Yu J, Liang P

Journal of Hepatocellular Carcinoma 2026, 13:603442

Published Date: 4 June 2026

Review

When Resectability Emerges After Systemic Therapy in Hepatocellular Carcinoma: A Proposed Response-Guided Consolidation Framework

Cheng Y, Xie K

Journal of Hepatocellular Carcinoma 2026, 13:613934

Published Date: 4 June 2026

Review

Histone Methylation: A Pivotal Epigenetic Driver of the Malignant Transformation of MASLD-HCC

Zhang Y, Chen T, Chang Z, Qi X, Yan R, Zhang H, Guan X, Yan S, Li J, Jiao J

Journal of Hepatocellular Carcinoma 2026, 13:598429

Published Date: 3 June 2026

Case report

Rare Long-Term Transformation from Solitary Hepatocellular Carcinoma to Synchronous Double Primary Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma: A Case Report and Literature Review

Qiao L, Wei P, Lo C, Luo Y, Peng Y, Kang Z, Gao J, Zhu J, Li Z

Journal of Hepatocellular Carcinoma 2026, 13:598850

Published Date: 28 May 2026

Original Research

Efficacy of Locoregional HAIC and Systemic Treatment for Treatment- Naive Unresectable Hepatocellulcar Carcinoma

Chen M, Zhang L, Liu C, Xu X, Zhang J, Yuan J, Ge N, Chen Y, Xie X, Zhang L, Chen R

Journal of Hepatocellular Carcinoma 2026, 13:606458

Published Date: 27 May 2026

Review

Decoding Treatment Response in Hepatocellular Carcinoma: The Era of Radiomics and Radiogenomics

Wang Z, Gan W, Gong J, Li X

Journal of Hepatocellular Carcinoma 2026, 13:595928

Published Date: 27 May 2026

Case report

Multimodal Conversion Therapy Enabling Curative Resection in Giant Hepatocellular Carcinoma with Arteriovenous Fistula: A Case Report

Zhong H, Tan L, Le W, Luo N, Shen Y, Long G, Xiong C, Tao H

Journal of Hepatocellular Carcinoma 2026, 13:599120

Published Date: 26 May 2026

Original Research

Dynamic AFP-Defined Disease State Transitions in Hospitalized Patients with Hepatocellular Carcinoma Using the Multi-State Markov Model: A Retrospective Cohort Study

Song Q, Zhang H, Jia M, Yu Y, Jiang Y, Yuan J, Su S

Journal of Hepatocellular Carcinoma 2026, 13:603210

Published Date: 26 May 2026

Original Research

HAIC Combined with Lenvatinib and Pembrolizumab for Unresectable Hepatocellular Carcinoma: A Retrospective Study

Liang J, Yang Z, Yang Z, Li H, Hong J, Pan Y, Fu Y, Wang J, Zhou Z, Zhang Y, Chen M, Chen J, Hu D

Journal of Hepatocellular Carcinoma 2026, 13:600557

Published Date: 26 May 2026

Original Research

SR-HCC Score: A Novel Nomogram for Predicting Spontaneous Rupture in Hepatocellular Carcinoma Patients

Gao S, Zhang X, Jia T, Jin Q, Yang X, Zhao R, Gao J

Journal of Hepatocellular Carcinoma 2026, 13:600415

Published Date: 25 May 2026

Original Research

Efficacy and Safety of TACE-HAIC Combined with Molecular Targeted Therapy and Immune Checkpoint Inhibitors for Unresectable Hepatocellular Carcinoma

Feng Z, Wang X, Xu J, Chen S, Hao M, Hu H, Qiu S, Liao Y, Yu W, Fang Z

Journal of Hepatocellular Carcinoma 2026, 13:588860

Published Date: 22 May 2026

Original Research

Development and Validation of a HAUS-Related Prognostic Signature in Liver Hepatocellular Carcinoma: A Multi-Omics Integration from Pan-Cancer Analysis to Single-Cell Resolution

Liu Y, Liu K, Ding Y, Li X, Shi X, Zhang J, Zhang X, Peng W, Deng J, Chen J

Journal of Hepatocellular Carcinoma 2026, 13:598179

Published Date: 22 May 2026

Original Research

A Preoperative MRI-Based Score to Predict High-Risk Pathology and Stratify Adjuvant Therapy Benefit in BCLC 0/A Hepatocellular Carcinoma

Li H, Wang X, Yu C, Li B, Hu Z, Li W, Chen Y, Zhou Y, Sun Y

Journal of Hepatocellular Carcinoma 2026, 13:605420

Published Date: 22 May 2026

Review

Post-Translational Modification Networks in Ferroptosis: Orchestrating Defense, Drug Resistance, and Therapeutic Opportunities in Hepatocellular Carcinoma

Chen J, Li L, Fang S, Zhou H

Journal of Hepatocellular Carcinoma 2026, 13:607656

Published Date: 21 May 2026

Original Research

Determinants of Fear of Cancer Recurrence and Development of a Nomogram-Based Risk Prediction Model in Patients with Primary Liver Cancer: A Single-Center Cross-Sectional Study

Du J, Shi C, Zhang Y, Li J, Yang D

Journal of Hepatocellular Carcinoma 2026, 13:611163

Published Date: 21 May 2026

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