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Clinical Epidemiology

ISSN: 1179-1349


Archive: Volume 8, 2016

Validation of celiac disease diagnoses recorded in the Danish National Patient Register using duodenal biopsies, celiac disease-specific antibodies, and human leukocyte-antigen genotypes

Dydensborg Sander S, Størdal K, Plato Hansen T, Nybo Andersen AM, Murray JA, Lillevang ST, Husby S

Clinical Epidemiology 2016, 8:789-799

Published Date: 15 December 2016

Validation of diagnostic codes for Charcot-Marie-Tooth disease in the Danish National Patient Registry

Vaeth S, Jensen UB, Christensen R, Andersen H

Clinical Epidemiology 2016, 8:783-787

Published Date: 21 November 2016

Recording of hospitalizations for acute exacerbations of COPD in UK electronic health care records

Rothnie KJ, Müllerová H, Thomas SL, Chandan JS, Smeeth L, Hurst JR, Davis K, Quint JK

Clinical Epidemiology 2016, 8:771-782

Published Date: 21 November 2016

Five-year risk of HIV diagnosis subsequent to 147 hospital-based indicator diseases: a Danish nationwide population-based cohort study [Erratum]

Omland LH, Legarth R, Ahlström MG, Sørensen HT, Obel N

Clinical Epidemiology 2016, 8:769-770

Published Date: 18 November 2016

Similar long-term survival of consecutive in-hospital and out-of-hospital cardiac arrest patients treated with targeted temperature management

Engsig M, Søholm H, Folke F, Gadegaard PJ, Wiis JT, Molin R, Mohr T, Engsig FN

Clinical Epidemiology 2016, 8:761-768

Published Date: 9 November 2016

Development of an algorithm to identify urgent referrals for suspected cancer from the Danish Primary Care Referral Database

Toftegaard BS, Guldbrandt LM, Flarup KR, Beyer H, Bro F, Vedsted P

Clinical Epidemiology 2016, 8:751-759

Published Date: 26 October 2016

Mesothelioma in the United States: a Surveillance, Epidemiology, and End Results (SEER)–Medicare investigation of treatment patterns and overall survival

Beebe-Dimmer JL, Fryzek JP, Yee CL, Dalvi TB, Garabrant DH, Schwartz AG, Gadgeel S

Clinical Epidemiology 2016, 8:743-750

Published Date: 26 October 2016

The Danish nationwide clinical register for patients with rheumatoid arthritis: DANBIO

Ibfelt EH, Jensen DV, Hetland ML

Clinical Epidemiology 2016, 8:737-742

Published Date: 25 October 2016

National Database of Geriatrics

Kannegaard PN, Vinding KL, Hare-Bruun H

Clinical Epidemiology 2016, 8:731-735

Published Date: 25 October 2016

The database of the Danish Renal Cancer Group

Petersen AC, Søgaard M, Mehnert F, Larsen EH, Donskov F, Azawi NH, Kromann-Andersen B

Clinical Epidemiology 2016, 8:725-729

Published Date: 25 October 2016

The Danish Ventral Hernia Database – a valuable tool for quality assessment and research

Helgstrand F, Jorgensen LN

Clinical Epidemiology 2016, 8:719-723

Published Date: 25 October 2016

The Danish Vascular Registry, Karbase

Eldrup N, Cerqueira C, de la Motte L, Rathenborg LK, Hansen AK

Clinical Epidemiology 2016, 8:713-718

Published Date: 25 October 2016

Danish Urogynaecological Database

Hansen UD, Gradel KO, Larsen MD

Clinical Epidemiology 2016, 8:709-712

Published Date: 25 October 2016

The Danish Testicular Cancer database

Daugaard G, Kier MGG, Bandak M, Mortensen MS, Larsson H, Søgaard M, Toft BG, Engvad B, Agerbæk M, Holm NV, Lauritsen J

Clinical Epidemiology 2016, 8:703-707

Published Date: 25 October 2016

The Danish Stroke Registry

Johnsen SP, Ingeman A, Hunborg HH, Schaarup SZ, Gyllenborg J

Clinical Epidemiology 2016, 8:697-702

Published Date: 25 October 2016

The Danish Schizophrenia Registry

Baandrup L, Cerqueira C, Haller L, Korshøj L, Voldsgaard I, Nordentoft M

Clinical Epidemiology 2016, 8:691-695

Published Date: 25 October 2016

The Danish Sarcoma Database

Jorgensen PH, Lausten GS, Pedersen AB

Clinical Epidemiology 2016, 8:685-690

Published Date: 25 October 2016

Danish Registry of Childhood and Adolescent Diabetes

Svensson J, Cerqueira C, Kjærsgaard P, Lyngsøe L, Hertel NT, Madsen M, Mortensen HB, Johannesen J

Clinical Epidemiology 2016, 8:679-683

Published Date: 25 October 2016

Danish Register of chronic obstructive pulmonary disease

Lange P, Tøttenborg SS, Sorknæs AD, Andersen JS, Søgaard M, Nielsen H, Thomsen RW, Nielsen KA

Clinical Epidemiology 2016, 8:673-678

Published Date: 25 October 2016

The Danish quality database for prehospital emergency medical services

Frischknecht Christensen E, Berlac PA, Nielsen H, Christiansen CF

Clinical Epidemiology 2016, 8:667-671

Published Date: 25 October 2016

Danish Quality Database for Mammography Screening

Mikkelsen EM, Njor SH, Vejborg I

Clinical Epidemiology 2016, 8:661-666

Published Date: 25 October 2016

The Danish Quality Database for Cervical Cancer Screening

Rygaard C

Clinical Epidemiology 2016, 8:655-660

Published Date: 25 October 2016

The Danish Prostate Cancer Database

Nguyen-Nielsen M, Høyer S, Friis S, Hansen S, Brasso K, Jakobsen EB, Moe M, Larsson H, Søgaard M, Nakano A, Borre M

Clinical Epidemiology 2016, 8:649-653

Published Date: 25 October 2016

Danish Pancreatic Cancer Database

Fristrup C, Detlefsen S, Hansen CP, Ladekarl M

Clinical Epidemiology 2016, 8:645-648

Published Date: 25 October 2016

Danish Palliative Care Database

Groenvold M, Adsersen M, Hansen MB

Clinical Epidemiology 2016, 8:637-643

Published Date: 25 October 2016

The Danish Nonmelanoma Skin Cancer Dermatology Database

Lamberg AL, Sølvsten H, Lei U, Vinding GR, Stender IM, Jemec GB, Vestergaard T, Thormann H, Hædersdal M, Dam TN, Olesen AB

Clinical Epidemiology 2016, 8:633-636

Published Date: 25 October 2016

The Danish Neuro-Oncology Registry

Hansen S

Clinical Epidemiology 2016, 8:629-632

Published Date: 25 October 2016

The Danish Nephrology Registry

Heaf J

Clinical Epidemiology 2016, 8:621-627

Published Date: 25 October 2016

The Danish Registry of Diabetic Retinopathy

Andersen N, Hjortdal JØ, Schielke Kc, Bek T, Grauslund J, Laugesen CS, Lund-Andersen H, Cerqueira C, Andresen J

Clinical Epidemiology 2016, 8:613-619

Published Date: 25 October 2016

The Danish National Registry for Biological Therapy in Inflammatory Bowel Disease

Larsen L, Jensen MD, Larsen MD, Nielsen RG, Thorsgaard N, Vind I, Wildt S, Kjeldsen J

Clinical Epidemiology 2016, 8:607-612

Published Date: 25 October 2016

The Danish National Register for Asthma

Backer V, Lykkegaard J, Bodtger U, Agertoft L, Korshoej L, Braüner EV

Clinical Epidemiology 2016, 8:601-606

Published Date: 25 October 2016

The Danish National Quality Database for Births

Andersson CB, Flems C, Kesmodel US

Clinical Epidemiology 2016, 8:595-599

Published Date: 25 October 2016

The Danish National Penile Cancer Quality database

Jakobsen JK, Öztürk B, Søgaard M

Clinical Epidemiology 2016, 8:589-594

Published Date: 25 October 2016

The Danish National Multiple Myeloma Registry

Gimsing P, Holmström MO, Klausen TW, Andersen NF, Gregersen H, Pedersen RS, Plesner T, Pedersen PT, Frederiksen M, Frølund U, Helleberg C, Vangsted A, de Nully Brown P, Abildgaard N

Clinical Epidemiology 2016, 8:583-587

Published Date: 25 October 2016

Danish National Lymphoma Registry

Arboe B, Josefsson P, Jørgensen J, Haaber J, Jensen P, Poulsen C, Rønnov-Jessen D, Pedersen RS, Pedersen P, Frederiksen M, Pedersen M, de Nully Brown P

Clinical Epidemiology 2016, 8:577-581

Published Date: 25 October 2016

The Danish National Database for Obstructive Sleep Apnea

Jennum PJ, Larsen P, Cerqueira C, Schmidt T, Tønnesen P

Clinical Epidemiology 2016, 8:573-576

Published Date: 25 October 2016

The Danish National Chronic Myeloid Neoplasia Registry

Bak M, Ibfelt EH, Stauffer Larsen T, Rønnov-Jessen D, Pallisgaard N, Madelung A, Udby L, Hasselbalch HC, Bjerrum OW, Andersen CL

Clinical Epidemiology 2016, 8:567-572

Published Date: 25 October 2016

The Danish National Chronic Lymphocytic Leukemia Registry

da Cunha-Bang C, Geisler CH, Enggaard L, Poulsen CB, de Nully Brown P, Frederiksen H, Bergmann OJ, Pulczynski EJ, Pedersen RS, Nielsen LH, Christiansen I, Niemann CU

Clinical Epidemiology 2016, 8:561-565

Published Date: 25 October 2016

The Danish National Acute Leukemia Registry

Østgård LSG, Nørgaard JM, Raaschou-Jensen KK, Pedersen RS, Rønnov-Jessen D, Pedersen PT, Dufva IH, Marcher CW, Nielsen OJ, Severinsen MT, Friis LS

Clinical Epidemiology 2016, 8:553-560

Published Date: 25 October 2016

The Danish Multiple Sclerosis Treatment Register

Magyari M, Koch-Henriksen N, Sørensen PS

Clinical Epidemiology 2016, 8:549-552

Published Date: 25 October 2016

The Danish Melanoma Database

Hölmich LR, Klausen S, Spaun E, Schmidt G, Gad D, Svane IM, Schmidt H, Lorentzen HF, Ibfelt EH

Clinical Epidemiology 2016, 8:543-548

Published Date: 25 October 2016

The Danish Lung Cancer Registry

Jakobsen E, Rasmussen TR

Clinical Epidemiology 2016, 8:537-541

Published Date: 25 October 2016

The Danish Knee Ligament Reconstruction Registry

Rahr-Wagner L, Lind M

Clinical Epidemiology 2016, 8:531-535

Published Date: 25 October 2016

The Danish Intensive Care Database

Christiansen CF, Møller MH, Nielsen H, Christensen S

Clinical Epidemiology 2016, 8:525-530

Published Date: 25 October 2016

The Danish Inguinal Hernia Database

Friis-Andersen H, Bisgaard T

Clinical Epidemiology 2016, 8:521-524

Published Date: 25 October 2016

The Danish Hysterectomy and Hysteroscopy Database

Topsoee MF, Ibfelt EH, Settnes A

Clinical Epidemiology 2016, 8:515-520

Published Date: 25 October 2016

The Danish Hip Arthroplasty Register

Gundtoft PH, Varnum C, Pedersen AB, Overgaard S

Clinical Epidemiology 2016, 8:509-514

Published Date: 25 October 2016

The Danish Heart Registry

Özcan C, Juel K, Flensted Lassen J, von Kappelgaard LM, Mortensen PE, Gislason G

Clinical Epidemiology 2016, 8:503-508

Published Date: 25 October 2016

The Danish Heart Failure Registry

Schjødt I, Nakano A, Egstrup K, Cerqueira C

Clinical Epidemiology 2016, 8:497-502

Published Date: 25 October 2016

The Danish Head and Neck Cancer database

Overgaard J, Jovanovic A, Godballe C, Grau Eriksen J

Clinical Epidemiology 2016, 8:491-496

Published Date: 25 October 2016

Danish Gynecological Cancer Database

Sørensen SM, Bjørn SF, Jochumsen KM, Jensen PT, Thranov IR, Hare-Bruun H, Seibæk L, Høgdall C

Clinical Epidemiology 2016, 8:485-490

Published Date: 25 October 2016

The Danish Fetal Medicine Database

Ekelund CK, Kopp TI, Tabor A, Petersen OB

Clinical Epidemiology 2016, 8:479-483

Published Date: 25 October 2016

The Danish Depression Database

Videbech P, Deleuran A

Clinical Epidemiology 2016, 8:475-478

Published Date: 25 October 2016

The Danish database for acute and emergency hospital contacts

Lassen AT, Jørgensen H, Jørsboe HB, Odby A, Brabrand M, Steinmetz J, Mackenhauer J, Kirkegaard H, Christiansen CF

Clinical Epidemiology 2016, 8:469-474

Published Date: 25 October 2016

Danish Colorectal Cancer Group Database

Ingeholm P, Gögenur I, Iversen LH

Clinical Epidemiology 2016, 8:465-468

Published Date: 25 October 2016

Danish Childhood Cancer Registry

Schrøder H, Rechnitzer C, Wehner PS, Rosthøj S, Møller JK, Lausen B, Petersen G, Nørgaard M

Clinical Epidemiology 2016, 8:461-464

Published Date: 25 October 2016

The Danish Cerebral Palsy Follow-up Program

Rasmussen HM, Nordbye-Nielsen K, Møller-Madsen B, Johansen M, Ellitsgaard N, Pedersen CR, Rackauskaite G, Engberg H, Pedersen NW

Clinical Epidemiology 2016, 8:457-460

Published Date: 25 October 2016

The Danish Cardiac Rehabilitation Database

Zwisler AD, Rossau HK, Nakano A, Foghmar S, Eichhorst R, Prescott E, Cerqueira C, Soja AMB, Gislason GH, Larsen ML, Andersen UO, Gustafsson I, Thomsen KK, Boye Hansen L, Hammer S, Viggers L, Christensen B, Kvist B, Lindström Egholm C, May O

Clinical Epidemiology 2016, 8:451-456

Published Date: 25 October 2016

Danish Breast Cancer Cooperative Group

Christiansen P, Ejlertsen B, Jensen MB, Mouridsen H

Clinical Epidemiology 2016, 8:445-449

Published Date: 25 October 2016

The Danish Bladder Cancer Database

Hansen E, Larsson H, Nørgaard M, Thind P, Jensen JB

Clinical Epidemiology 2016, 8:439-443

Published Date: 25 October 2016

The Danish Anaesthesia Database

Antonsen K, Rosenstock CV, Lundstrøm LH

Clinical Epidemiology 2016, 8:435-438

Published Date: 25 October 2016

The Danish Adult Diabetes Registry

Jørgensen ME, Kristensen JK, Reventlov Husted G, Cerqueira CS, Rossing P

Clinical Epidemiology 2016, 8:429-434

Published Date: 25 October 2016

Danish clinical quality databases – an important and untapped resource for clinical research

Sørensen HT, Pedersen L, Jørgensen J, Ehrenstein V

Clinical Epidemiology 2016, 8:425-427

Published Date: 25 October 2016

Evaluation of algorithms for registry-based detection of acute myocardial infarction following percutaneous coronary intervention

Egholm G, Madsen M, Thim T, Schmidt M, Christiansen EH, Bøtker HE, Maeng M

Clinical Epidemiology 2016, 8:415-423

Published Date: 19 October 2016

Vejle Diabetes Biobank – a resource for studies of the etiologies of diabetes and its comorbidities

Petersen ERB, Nielsen AA, Christensen H, Hansen T, Pedersen O, Christensen CK, Brandslund I

Clinical Epidemiology 2016, 8:393-413

Published Date: 21 October 2016

The RECORD reporting guidelines: meeting the methodological and ethical demands of transparency in research using routinely-collected health data

Nicholls SG, Langan SM, Sørensen HT, Petersen I, Benchimol EI

Clinical Epidemiology 2016, 8:389-392

Published Date: 19 October 2016

Nationwide trends in glucose-lowering drug use, Denmark, 1999–2014

Christensen DH, Rungby J, Thomsen RW

Clinical Epidemiology 2016, 8:381-387

Published Date: 14 October 2016

Agreement between PRE2DUP register data modeling method and comprehensive drug use interview among older persons

Taipale H, Tanskanen A, Koponen M, Tolppanen AM, Tiihonen J, Hartikainen S

Clinical Epidemiology 2016, 8:363-371

Published Date: 11 October 2016

Prevalence and comorbidity of relapsing polychondritis

Ludvigsson JF, van Vollenhoven R

Clinical Epidemiology 2016, 8:361-362

Published Date: 30 September 2016

Danish Prostate Cancer Registry – methodology and early results from a novel national database

Helgstrand JT, Klemann N, Røder MA, Toft BG, Brasso K, Vainer B, Iversen P

Clinical Epidemiology 2016, 8:351-360

Published Date: 27 September 2016

Health service use among children with and without eczema, asthma, and hay fever

Hammer-Helmich L, Linneberg A, Thomsen SF, Tang L, Glümer C

Clinical Epidemiology 2016, 8:341-349

Published Date: 13 September 2016

Five-year risk of HIV diagnosis subsequent to 147 hospital-based indicator diseases: a Danish nationwide population-based cohort study

Omland LH, Legarth R, Ahlström MG, Sørensen HT, Obel N

Clinical Epidemiology 2016, 8:333-340

Published Date: 6 September 2016

Association between Global Assessment of Functioning scores and indicators of functioning, severity, and prognosis in first-time schizophrenia

Köhler O, Horsdal HT, Baandrup L, Mors O, Gasse C

Clinical Epidemiology 2016, 8:323-332

Published Date: 2 September 2016

Cholesterol testing among men and women with disability: the role of morbidity

Lofters AK, Guilcher SJT, Webster L, Glazier RH, Jaglal SB, Bayoumi AM

Clinical Epidemiology 2016, 8:313-321

Published Date: 1 September 2016

Interrater reliability of a national acute myocardial infarction register

Govatsmark RES, Sneeggen S, Karlsaune H, Slørdahl SA, Bønaa KH

Clinical Epidemiology 2016, 8:305-312

Published Date: 17 August 2016

I-determinants for a successful PhD or postdoctoral outcome

Sørensen HT

Clinical Epidemiology 2016, 8:297-303

Published Date: 12 August 2016

Letter to the editor

Linde A, Plymoth A

Clinical Epidemiology 2016, 8:295-296

Published Date: 8 August 2016

Maternal and infant characteristics: differences and similarities between the Nordic countries and the US

Löfling L, Bröms G, Bahmanyar S, Kieler H

Clinical Epidemiology 2016, 8:285-294

Published Date: 3 August 2016

Algorithm linking patients and general practices in Denmark using the Danish National Health Service Register

Kjaersgaard MIS, Vedsted P, Parner ET, Bech BH, Vestergaard M, Flarup KR, Fenger-Grøn M

Clinical Epidemiology 2016, 8:273-283

Published Date: 9 August 2016

Design and methods for a Scandinavian pharmacovigilance study of osteonecrosis of the jaw and serious infections among cancer patients treated with antiresorptive agents for the prevention of skeletal-related events

Acquavella J, Ehrenstein V, Schiødt M, Heide-Jørgensen U, Kjellman A, Hansen S, Larsson Wexell C, Herlofson BB, Noerholt SE, Ma H, Ӧhrling K, Hernandez RK, Sørensen HT

Clinical Epidemiology 2016, 8:267-272

Published Date: 20 July 2016

Reporting quality of stepped wedge design randomized trials: a systematic review protocol

Thabane A, Dennis BB, Gajic-Veljanoski O, Paul J, Thabane L

Clinical Epidemiology 2016, 8:261-266

Published Date: 8 July 2016

Prevalence of human norovirus and Clostridium difficile coinfections in adult hospitalized patients

Stokely JN, Niendorf S, Taube S, Hoehne M, Young VB, Rogers MAM, Wobus CE

Clinical Epidemiology 2016, 8:253-260

Published Date: 28 June 2016

Positive predictive value of diagnosis coding for hemolytic anemias in the Danish National Patient Register

Hansen DL, Overgaard UM, Pedersen L, Frederiksen H

Clinical Epidemiology 2016, 8:241-252

Published Date: 24 June 2016

A nationwide study of the epidemiology of relapsing polychondritis

Horváth A, Páll N, Molnár K, Kováts T, Surján G, Vicsek T, Pollner P

Clinical Epidemiology 2016, 8:211-230

Published Date: 23 June 2016

Implementation of interval walking training in patients with type 2 diabetes in Denmark: rationale, design, and baseline characteristics

Ried-Larsen M, Thomsen RW, Berencsi K, Brinkløv CF, Brøns C, Valentiner LS, Karstoft K, Langberg H, Vaag AA, Pedersen BK, Nielsen JS

Clinical Epidemiology 2016, 8:201-209

Published Date: 8 June 2016

Challenges in translating end points from trials to observational cohort studies in oncology

Ording AG, Cronin-Fenton D, Ehrenstein V, Lash TL, Acquavella J, Rørth M, Sørensen HT

Clinical Epidemiology 2016, 8:195-200

Published Date: 11 June 2016

Validation of self-reported and hospital-diagnosed atrial fibrillation: the HUNT-study

Malmo V, Langhammer A, Bønaa KH, Loennechen JP, Ellekjaer H

Clinical Epidemiology 2016, 8:185-193

Published Date: 11 June 2016

Changing prevalence and the risk factors for antenatal obstetric hospitalizations in Denmark 2003-2012

Bendix J, Hegaard HK, Langhoff-Roos J, Bergholt T

Clinical Epidemiology 2016, 8:165-175

Published Date: 11 June 2016

Decade-long trends in the timeliness of receipt of a primary percutaneous coronary intervention

Chen HY, Gore JM, Lapane KL, Yarzebski J, Person SD, Kiefe CI, Goldberg RJ

Clinical Epidemiology 2016, 8:141-149

Published Date: 6 June 2016

Validity of the coding for herpes simplex encephalitis in the Danish National Patient Registry

Jørgensen LK, Dalgaard LS, Østergaard LJ, Andersen NS, Nørgaard M, Mogensen TH

Clinical Epidemiology 2016, 8:133-140

Published Date: 31 May 2016

Stage-specific survival and recurrence in patients with cutaneous malignant melanoma in Europe – a systematic review of the literature

Svedman FC, Pillas D, Taylor A, Kaur M, Linder R, Hansson J

Clinical Epidemiology 2016, 8:109-122

Published Date: 26 May 2016

Epidemiological characteristics of chronic fatigue syndrome/myalgic encephalomyelitis in Australian patients

Johnston SC, Staines DR, Marshall-Gradisnik SM

Clinical Epidemiology 2016, 8:97-107

Published Date: 17 May 2016

Incidence of anemia in patients diagnosed with solid tumors receiving chemotherapy, 2010–2013

Xu H, Xu L, Page JH, Cannavale K, Sattayapiwat O, Rodriguez R, Chao C

Clinical Epidemiology 2016, 8:61-71

Published Date: 18 April 2016

Cardiac dysfunction among soft tissue sarcoma patients in Denmark

Shantakumar S, Olsen M, Vo TT, Nørgaard M, Pedersen L

Clinical Epidemiology 2016, 8:53-59

Published Date: 15 April 2016

Helping everyone do better: a call for validation studies of routinely recorded health data

Ehrenstein V, Petersen I, Smeeth L, Jick SS, Benchimol EI, Ludvigsson JF, Sørensen HT

Clinical Epidemiology 2016, 8:49-51

Published Date: 12 April 2016

Treatment outcomes of HIV-positive patients on first-line antiretroviral therapy in private versus public HIV clinics in Johannesburg, South Africa

Moyo F, Chasela C, Brennan AT, Ebrahim O, Sanne IM, Long L, Evans D

Clinical Epidemiology 2016, 8:37-47

Published Date: 18 March 2016

Natural history of bleeding and characteristics of early bleeders among warfarin initiators – a cohort study in Finland

Rikala M, Kastarinen H, Tiittanen P, Huupponen R, Korhonen MJ

Clinical Epidemiology 2016, 8:23-35

Published Date: 5 February 2016

The COLOFOL trial: study design and comparison of the study population with the source cancer population

Hansdotter Andersson P, Wille-Jørgensen P, Horváth-Puhó E, Petersen SH, Martling A, Sørensen HT, Syk I

Clinical Epidemiology 2016, 8:15-21

Published Date: 28 January 2016

Pilot study of participant-collected nasal swabs for acute respiratory infections in a low-income, urban population

Vargas CY, Wang L, Castellanos de Belliard Y, Morban M, Diaz H, Larson EL, LaRussa P, Saiman L, Stockwell MS

Clinical Epidemiology 2016, 8:1-5

Published Date: 6 January 2016