The Danish nationwide clinical register for patients with rheumatoid arthritis: DANBIO
Authors Ibfelt EH, Jensen DV, Hetland ML
Received 22 November 2015
Accepted for publication 28 January 2016
Published 25 October 2016 Volume 2016:8 Pages 737—742
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Professor Henrik Toft Sørensen
Else Helene Ibfelt,1 Dorte Vendelbo Jensen,2,3 Merete Lund Hetland2,4
1Registry Support Centre (East), Epidemiology and Biostatistics, Research Centre for Prevention and Health, Rigshospitalet, Glostrup University Hospital, 2DANBIO Registry and Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Centre of Head and Orthopedics, Rigshospitalet, Glostrup, 3Department of Rheumatology, Herlev and Gentofte University Hospital, Hellerup, 4Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Introduction: DANBIO is a research register and a data source for rheumatologic diseases (rheumatoid arthritis [RA], axial spondyloarthritis, and psoriatic arthritis) for monitoring clinical quality at the national, regional, and hospital levels.
Study population: The register includes patients with rheumatologic diseases who are treated at a hospital or a private rheumatologic clinic. Registration is mandatory for all patients with RA regardless of treatment and also for patients with other diagnoses if treated with biological disease-modifying antirheumatic drugs. Since 2006, the registration has been done electronically, including patient-reported outcome measures registered electronically by the patients with the use of touch screens.
Main variables: Core variables such as diagnosis, year of diagnosis, age, and sex are registered at the beginning. Data entered at later visits included the following: patient-reported outcomes for disease activity, pain, fatigue, functional status, and physician-reported objective measures of disease activity, treatment, C-reactive protein, and, when indicated, imaging. For subgroups of patients, the variables such as quality of life, sociodemographic factors, lifestyle, and comorbidity are also registered.
Descriptive data: The DANBIO cohort comprised ~26,000 patients with RA, 3,200 patients with axial spondyloarthritis, and 6,200 patients with psoriatic arthritis in 2015. DANBIO has high nationwide coverage and completeness on key data variables. More than 60 original papers as well as annual reports of clinical quality (since 2005) have been published.
Conclusion: DANBIO is a powerful register for research in rheumatologic diseases and furthermore serves as a Clinical Quality Register with the aim of monitoring treatment quality in patients with RA in Denmark.
Keywords: rheumatoid arthritis, axial spondyloarthritis, psoriatic arthritis, DANBIO register clinical quality, epidemiology
The database, DANBIO, is a nationwide, Danish register for research use in rheumatologic diseases such as rheumatoid arthritis (RA), axial spondyloarthritis (Ax SpA), and psoriatic arthritis (PsA). It also serves as a clinical database that monitors clinical quality of treatment by the use of selected quality indicators for patients with RA in Denmark.
Study population and data collection
Up to the year 2000, no routine-based nationwide reporting of patients with RA existed in Denmark, and patient files rarely comprised quantitative patient-reported outcome data. The introduction of new biological disease-modifying antirheumatic drugs (bDMARDs) triggered the formation of a nationwide voluntary register, which aimed to survey indications for treatment, efficacy, and adverse events in rheumatologic patients who received biological therapies in routine care.
In the beginning, data were collected on paper forms, which were subsequently scanned into the register at the DANBIO office.1 In 2006, an online version of DANBIO was introduced, and the aims were extended to include patients regardless of treatment and also to collect patient-reported outcomes regarding, eg disability, pain, lifestyle, and quality of life by the use of dedicated touch screens in the waiting room (Figure 1). This is routinely done before consultation with the doctor, and the information from the touch screen is available during the consultation. DANBIO has been approved by the National Board of Health as a Clinical Quality Register, and since 2006, reporting to the register has been mandatory. For clinical quality registers, the usual requirement for obtaining an informed patient consent before registration is not needed. Only rarely do patients object to be included in the register, and in these cases, it is up to the physician to decide whether to register the patient or not.
Figure 1 A patient using the touch screen
RA, Ax SpA, and PsA are chronic diseases that require lifelong monitoring and treatment. A patient is therefore reported to the database at the time of diagnosis, referral to specialized treatment, including biological therapy at the hospital, or in a private rheumatologic clinic. At the first registration, the diagnosis, date of diagnosis, age, sex, and previous medical treatment are registered. At later visits, and at least once yearly, information regarding patient’s disease activity (including pain and functional status) is collected via touch screens, and objective measures (eg, swollen and tender joint counts, C-reactive protein) are entered by the physician.
The patient groups with Ax SpA and PsA are not included at the moment in the National Clinical Quality Program, and therefore reporting is only mandatory for patients with RA and for the other patient groups only when treated with bDMARDs. In the beginning of 2015, the DANBIO cohort comprised ~26,000 patients with RA, 3,200 patients with Ax SpA, and 6,200 patients with PsA treated with conventional synthetic DMARDs and/or bDMARDs.
Table 1 gives the key variables of the register. Some variables are collected via touch screens (patient-reported outcome measures [PROMs]), and others are entered by the physician.
Table 1 Key variables in the DANBIO register
The use of touch screens for data collection has been validated to perform equally well as paper forms (Figure 1).2 The variables are collected in a standardized format, often using tick boxes, which have been shown to have a high validity.1 Figure 2 shows the scoreboard for entering and reviewing individual patient data. In connection with ie, queries from DANBIO and research projects, the departments fill in missing data by checking against the hospital patient records.
Figure 2 Overview of patient data.
The completeness of data is generally high (ie, 96%, 93%, 83%, 90%, and 93% for information on the name of the treating doctor, diagnosis, year of diagnosis, DAS28, and HAQ, respectively). National coverage of DANBIO is assessed annually in two ways: for patients in biological treatment by comparing to those registered in the patient record systems of each rheumatologic department (94% in 2013) and by calculation of all incident patients with RA in DANBIO by comparison to the Danish National Patient Registry (NPR; 85% in 2013). Since NPR is an administrative register3 in which RA diagnosis may be registered for patient contacts before the final diagnosis of the patient has been established, it cannot serve as a golden standard; however, it is the most valid nationwide register available for such comparison. Further, local medical record audits have shown that the diagnosis in DANBIO is valid. Therefore, it is assumed that the true coverage of DANBIO is higher than this estimate.4
At least once-a-year follow-up information is collected in DANBIO, including PROMs such as the level of function and level of pain. Disease activity, type of treatment, treatment effectiveness, and side effects of treatment (if any) are registered by the physician.5
Systematic monitoring of patients with RA with real-time feedback to the physician is feasible. It is documented that regular registration of disease activity for patients with RA results in improvement in disease activity, although the goal of treat to target is not achieved in a substantial proportion of patients in routine care.6
The current quality indicators for RA are shown in Table 2. The indicators include goals for whether patients are “treated to target” (ie, remission or low disease activity) by follow-up of patients with measurement and registration of disease activity level, functional status, pain, quality of life, and X-ray status. A standard for each indicator is set by the DANBIO steering committee and by consensus among the members of the Danish Society of Rheumatology setting goals for how large a fraction of patients who should meet the indicator criteria. The indicator results are published at country, regional, and hospital department levels in the Annual Clinical Quality Report.4 An example of supplementary results from the quality report is presented in Figure 3 that gives the number of adult rheumatologic patients initiating bDMARDs in Denmark over time and the differences in prescription pattern between geographical regions.4
Figure 3 Number of adult rheumatologic patients initiating bDMARDs in Denmark over time across the geographical regions.
Examples of research
DANBIO is used in routine care for systematic monitoring of the patients, but it is also an extensive research database.
DANBIO data have been used for research with focus on both short- and long-term evaluation of treatment responses, remission rates, and drug adherence.7–10 Furthermore, research has been performed on cancer incidence and precancerous development following treatments with biological treatment regimes,11,12 as well as on the influence of tobacco smoking on treatment response.13
More than 60 peer-reviewed articles have been published to date with the use of DANBIO data and >170 abstracts have been presented at international conferences and congresses.
DANBIO is easily linked to other data sources by the use of the unique personal identification number, assigned to all Danish citizens. With regulatory approval for specific research purposes, DANBIO data can be merged with ie, the NPR, the Danish Cancer Registry, or administrative registers holding socioeconomic information in Statistic Denmark.
A nationwide biobank (ie, blood and synovial fluid) associated with DANBIO has been established since 2015 through public funding.
Administrative issues and funding
DANBIO has an independent steering committee with representatives from the Danish Society of Rheumatology, DRFO (Danske Reumatologer og Fysiurgers Organisation), Junior Rheumatologists (Yngre Reumatologer), and the hospital owners. The daily administration is handled in the DANBIO general office at Rigshospitalet, Glostrup, and is staffed by the Head of Secretariat as well as a secretary.
DANBIO has been approved as a clinical quality register by the Danish authorities – the National Board of Health and the Danish Data Protection Agency – and is sponsored by the public hospital owners (Danish Regions) under the organization of the Danish Clinical Registries – a national improvement program. The pharmaceutical companies that provide biological treatments in rheumatology contribute to the development of the information technology platform through unrestricted grants, which have been approved by the public hospital owners. The sponsors have no influence on the register setup, data collection, data analysis, or publication of results. These issues are all administered by the steering committee.
DANBIO serves as a powerful register for research in rheumatologic diseases and additionally as a clinical quality register with the aim of monitoring quality by the use of selected clinical indicators for patients with RA in Denmark.
The register has existed since 2000, and patients diagnosed at the hospital or at private rheumatologic clinic are registered. Since 2006, the registration, including PROMs, has been electronically registered directly into the database with the use of touch screens.
DANBIO has high nationwide coverage of patients with rheumatologic diseases and high completeness on key data variables. Data have been used for a large number of research projects and each year a National Clinical Quality Report is published.
This paper was funded by the Program for Clinical Research Infrastructure established by the Lundbeck Foundation and the Novo Nordisk Foundation and administered by the Danish Regions. DANBIO thanks the Danish Regions for supporting the register. All the Departments of Rheumatology in Demark and the private rheumatologic clinics are acknowledged for using the register. Niels Steen Krogh, Zitelab ApS, is acknowledged for the continuous technical development and support of the register.
The authors report no conflicts of interest in this work.
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