Journal of Pain Research
Pre-Clinical/Scientific
Section Editor(s): Professor Romero-Sandoval, Pain Mechanisms Laboratory, Wake Forest University School of Medicine, Winston Salem, NC, USAProfessor Imlach , Monash Biomedicine Discovery Institute, Monash University, Melbourne, Vic, AustraliaThe section on pre-clinical models is a broad one, and notably includes the investigation of changes in the nervous system that drive and maintain chronic pain states. The section seeks to understand the origin and persistence of different types of pain and the translation of scientific discoveries into clinical practice.
Latest articles in Pre-Clinical/Scientific:
- 25 records -
LC-IL but Not LC-PL Circuit Regulates Comorbid Mechanical Hyperalgesia and Anxiety in Male Rats with Chronic Post-Surgical Pain
Lin S, Liu C, Jiang X, Lin M, Wang F, Zhuo Y, Lin K, Lin C, Liu R
Journal of Pain Research 2026, 19:585416
Published Date: 10 July 2026
Rethinking Pain Assessment: Subjective Scales, Biomarkers, and Multimodal Integration
Liu A, Zhang L, Xue E, Zhang C, Guo T, Wang J, Ming D
Journal of Pain Research 2026, 19:617733
Published Date: 10 July 2026
Dorsal Root Ganglion as a Hub for Peripheral Sensitization: A Hierarchical Regulation Model and Translational Progress
Cui A, Meng X, Wang Z, Wu Q, Li M
Journal of Pain Research 2026, 19:601365
Published Date: 10 July 2026
Ge-Gen Decoction Modulates the HSP90/AKT Signaling Pathway and the NLRP3 Inflammasome to Alleviate Primary Dysmenorrhea
Xie Y, Xu L, He Y
Journal of Pain Research 2026, 19:612129
Published Date: 8 July 2026
Inflammatory and Molecular Mechanisms of Adenomyosis Associated Pain: Insights from Multiple Analytic Approaches
Kwon K, Kwon JY, Sheen K, Yu S, Kim YA, Yoo EH, Lee K, Kim MS
Journal of Pain Research 2026, 19:606781
Published Date: 8 July 2026
Pharmacological Inhibition of Tropomyosin Receptor Kinase B Reverses Remifentanil-Induced Postoperative Hyperalgesia and Synaptic Remodeling
Yang L, Huang Y, Long B
Journal of Pain Research 2026, 19:598801
Published Date: 29 June 2026
Antioxidant Therapy Reverses Sound Stress-Induced Opioid Resistance in a Mouse Model of Mechanical Allodynia
Kasai S, Furuta A, Kuroda J, Takagi M, Sawai T, Yamada D, Saitoh A, Yoshizawa K
Journal of Pain Research 2026, 19:550094
Published Date: 25 June 2026
Effect of Pulsed Radiofrequency with Various Time-Course on Rheumatoid Arthritis Joint Pain in Rats
Li X, Wang M, Wang Y, Zhao G, Gao J, Wang C
Journal of Pain Research 2026, 19:588393
Published Date: 22 May 2026
Experimental Gestational Diabetes Mellitus Prolongs Post-Incisional Mechanical Hypersensitivity and Increases Cutaneous Neuro-Immune Markers in Adult Female Offspring
Cantú-Cepeda CA, Villarreal-Salcido J, Elizondo-Martinez CE, Vazquez-Mora JA, Martínez-Martínez A, Acosta-González RI, Jiménez-Andrade JM, Muñoz-Islas E
Journal of Pain Research 2026, 19:594897
Published Date: 19 May 2026
Gender-Specific Behavior Reductions in Spontaneous Locomotive and Rearing in a Rat Model of Paclitaxel-Induced Peripheral Neuropathy: A Pilot Study
Kim SJ, Cao K, Dougherty PM, McDonough KE, Javed S
Journal of Pain Research 2026, 19:565512
Published Date: 16 May 2026
Transcranial Direct Current Stimulation Targeting the Primary Motor Cortex Suppresses Activity in the Ventrolateral Periaqueductal Gray and Alleviates Chronic Pain in a Rat Model of Knee Osteoarthritis
Xu Y, Fan C, Xue J, Gao C, Zhou Y, Li T
Journal of Pain Research 2026, 19:595212
Published Date: 6 May 2026
Metabolomics Analysis Reveals Gut Microbiota-Associated Sakuranin Modulates Endometrial Stem Cell Differentiation and Inflammation to Alleviate Pain in Endometriosis [Response to Letter]
Shi W, Wang M, Jin Z, Chen X, Li J, Lai H, Li X, Zhong Q, Chen Y, Chen S
Journal of Pain Research 2026, 19:608988
Published Date: 16 April 2026
A Comprehensive Review of the Clinical Utility and Reliability of a Quantitative Electrical Stimulation Device for Objective Pain Assessment
Kato K
Journal of Pain Research 2026, 19:585386
Published Date: 3 April 2026
Exploring the Influence of Testosterone on Pain Perception and Modulation Among Men with Low and Normal Testosterone Concentrations
Vincenot M, Bordeleau M, le Blanc F, Pagé C, Gaumond I, Léonard G, Marchand S
Journal of Pain Research 2026, 19:571741
Published Date: 27 March 2026
Experimental Investigation of Fentanyl Analgesic Potency and Its Relationship with Endogenous Adrenaline Levels in Rats
Ates I, Isik B, Sezgin ET, Altuner D, Coban TA, Suleyman H
Journal of Pain Research 2026, 19:582322
Published Date: 25 March 2026
Metabolomics Analysis Reveals Gut Microbiota-Associated Sakuranin Modulates Endometrial Stem Cell Differentiation and Inflammation to Alleviate Pain in Endometriosis [Letter]
Liu Y
Journal of Pain Research 2026, 19:607364
Published Date: 12 March 2026
Differences in Experimental Pain Sensitivity Between Non-African and African American Healthy Individuals and Patients with Painful Chronic Pancreatitis
Phillips AE, Faghih M, Ramsey ML, Han S, Hart PA, Afghani E, Bick BL, Easler JJ, Yadav D, Wilcox CM, Olesen SS, Drewes AM, Singh VK
Journal of Pain Research 2026, 19:562097
Published Date: 25 February 2026
Reliability and Validity of Non-Invasive Electrical Detection and Pain Thresholds Using PainVision® in Healthy Young Adults
Yu S, Yang Z, Chen B, Wang L, Huang J, Gou L, Yang L
Journal of Pain Research 2026, 19:561240
Published Date: 17 February 2026
Metabolomics Analysis Reveals Gut Microbiota-Associated Sakuranin Modulates Endometrial Stem Cell Differentiation and Inflammation to Alleviate Pain in Endometriosis
Shi W, Wang M, Jin Z, Chen X, Li J, Lai H, Li X, Zhong Q, Chen Y, Chen S
Journal of Pain Research 2026, 19:557430
Published Date: 17 February 2026
An Overview of Ischemic Preconditioning as a Potential Therapeutic Target for Chronic Muscle Pain
Zhang Q, Luo J
Journal of Pain Research 2026, 19:546782
Published Date: 13 January 2026
Ginger Moxibustion Activates TRPV1 to Modulate the Locus Coeruleus-Spinal Cord-Uterus Pathway and Alleviates Primary Dysmenorrhea in Rats
Wang X, Yang L, Bi K, Zhou M, Wang D, Zhao Z, Mi S, Li X
Journal of Pain Research 2025, 18:7109-7125
Published Date: 25 December 2025
LncRNA-Associated ceRNA Network in the Spinal Cord Reveals the Central Mechanism of Chronic Inflammatory Visceral Pain
Li X, Wang X, Dong X, Li Z, Lu Y, Liu L, Yang G, Hong J, Yang Y, Zhang C, Wu H, Zhang D, Ma X
Journal of Pain Research 2025, 18:6853-6868
Published Date: 17 December 2025
Modulatory Effects of “Minor” Cannabinoids in an in vitro Model of Neuronal Hypersensitivity
Anand U, Anand P, Sodergren MH
Journal of Pain Research 2025, 18:6259-6274
Published Date: 24 November 2025
Unexpected Role of TNFα Signaling in the Resolution of Postoperative Pain in Mice
Laumet S, Edwards AM, Inyang KE, Laumet G
Journal of Pain Research 2025, 18:6057-6063
Published Date: 12 November 2025
Microglia’s Phenotypic Heterogeneity in Pain Pathogenesis and Electroacupuncture Analgesia: Mechanisms and Therapeutic Potential
Ji D, Lyu Z, Erasmus S, Wu Y, Li X, Chen X, Fang J, Du J, Fang J, Zhou J, Liang Y
Journal of Pain Research 2025, 18:6007-6022
Published Date: 11 November 2025