Drug Design, Development and Therapy

Therapeutic advances in adipose tissue dysfunction and bone health in obesity and insulin resistance

The adipose tissue is a large and varied endocrine organ, consisting of different types of fat cells and other cell types (i.e., endothelial cells, fibroblasts, and immune cells) with unique secretory properties. It can influence almost every aspect of body function. In mammals, the adipose tissue grows and develops in utero in relation to maternal blood glucose levels, and if challenged after birth with overnutrition, it may continue to expand almost indefinitely, causing obesity and its attendant metabolic consequences, such as insulin resistance. This Article Collection focuses on the latest pharmacological advances for treating obesity, insulin resistance, and their related metabolic/health consequences.