Drug Design, Development and Therapyhttps://www.dovepress.com/feed/journal/19New articles released by Dove Press for Drug Design, Development and Therapyen-us2026, Dove Pressangela@dovepress.com (Angela Jones)Dove Press Drug Design, Development and TherapyDrug Design, Development and Therapyhttps://www.dovepress.com/feed/journal/19https://www.dovepress.com/assets/img/addon/rss-banner.jpg140140Is Thoracic Paravertebral Block Truly Superior to Erector Spinae Plane Block? Re-Evaluating the Evidence from a Recovery Perspective [Response to Letter]https://www.dovepress.com/is-thoracic-paravertebral-block-truly-superior-to-erector-spinae-pla-2-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyTue, 07 Jul 2026 15:31:00 +1200https://doi.org/10.2147/DDDT.S634713The Efficacy and Safety of Telitacicept versus the Recommended Regimens in IgA Nephropathy: A Single-Center Experiencehttps://www.dovepress.com/the-efficacy-and-safety-of-telitacicept-versus-the-recommended-regimen-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyTue, 07 Jul 2026 15:29:00 +1200https://doi.org/10.2147/DDDT.S618596Metformin Sensitizes HR+/HER2- Breast Cancer Cells to CDK4/6 Inhibitor via Suppressing of PI3K/AKT/mTOR Signaling Pathwayhttps://www.dovepress.com/metformin-sensitizes-hrher2--breast-cancer-cells-to-cdk46-inhibitor-vi-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyFri, 03 Jul 2026 07:32:00 +1200https://doi.org/10.2147/DDDT.S544583The Median Effective Infusion Rate of Ciprofol with Different Doses of Esketamine During Gastrointestinal Endoscopy: A Randomized Controlled Trialhttps://www.dovepress.com/the-median-effective-infusion-rate-of-ciprofol-with-different-doses-of-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyFri, 03 Jul 2026 07:27:00 +1200https://doi.org/10.2147/DDDT.S557205Donidalorsen for the Treatment of Hereditary Angioedema: A Review of Clinical Studieshttps://www.dovepress.com/donidalorsen-for-the-treatment-of-hereditary-angioedema-a-review-of-cl-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyFri, 03 Jul 2026 07:25:00 +1200https://doi.org/10.2147/DDDT.S589693Updated Real-World Outcomes with Brentuximab Vedotin in Chinese Lymphoma Patients: A Multicenter, Retrospective Studyhttps://www.dovepress.com/updated-real-world-outcomes-with-brentuximab-vedotin-in-chinese-lympho-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyFri, 03 Jul 2026 07:17:00 +1200https://doi.org/10.2147/DDDT.S607574The Optimal Dose of Butorphanol Combined with Ropivacaine for Supraclavicular Brachial Plexus Block in Patients Undergoing Upper Limb Fracture Surgery: A Randomized, Double-Blind, Controlled Clinical Trialhttps://www.dovepress.com/the-optimal-dose-of-butorphanol-combined-with-ropivacaine-for-supracla-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyFri, 03 Jul 2026 07:11:00 +1200https://doi.org/10.2147/DDDT.S610539Effectiveness and Safety of Anlotinib with or without PD-1 Blockades in Patients with Platinum-Resistant or Immunotherapy-Resistant Recurrent/Metastatic Nasopharyngeal Carcinoma: A Retrospective, Real-World Studyhttps://www.dovepress.com/effectiveness-and-safety-of-anlotinib-with-or-without-pd-1-blockades-2-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyFri, 03 Jul 2026 07:09:00 +1200https://doi.org/10.2147/DDDT.S610324Effect of Remimazolam on Postoperative Delirium in Elderly Surgical Patients: A Critical Review of Pharmacological Mechanisms and Clinical Evidencehttps://www.dovepress.com/effect-of-remimazolam-on-postoperative-delirium-in-elderly-surgical-pa-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyFri, 03 Jul 2026 07:00:00 +1200https://doi.org/10.2147/DDDT.S614204Metabolomics-Driven Precision Prevention and Treatment of Heart Failure with Traditional Chinese Medicine: From Mechanistic Insights to Metabolic Network Regulationhttps://www.dovepress.com/metabolomics-driven-precision-prevention-and-treatment-of-heart-failur-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyTue, 30 Jun 2026 18:50:00 +1200https://doi.org/10.2147/DDDT.S605498Pterostilbene in Oxidative Stress–Related Diseases: Context-Dependent Regulation of Redox Homeostasis and Translational Challengeshttps://www.dovepress.com/pterostilbene-in-oxidative-stressrelated-diseases-context-dependent-re-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyTue, 30 Jun 2026 17:35:00 +1200https://doi.org/10.2147/DDDT.S608538Therapeutic Potential of Ziyuglycosides from Sanguisorba officinalis: Anticancer and Immunomodulatory Propertieshttps://www.dovepress.com/therapeutic-potential-of-ziyuglycosides-from-sanguisorba-officinalis-a-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyTue, 30 Jun 2026 17:30:00 +1200https://doi.org/10.2147/DDDT.S591949Design, Synthesis and Biological Evaluation of New Oxazolidinone Antimicrobial Agents with Low Monoamine Oxidase A Inhibitionhttps://www.dovepress.com/design-synthesis-and-biological-evaluation-of-new-oxazolidinone-antimi-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyTue, 30 Jun 2026 00:45:00 +1200https://doi.org/10.2147/DDDT.S596564ED50 and ED95 of Remimazolam Combined with Sufentanil for Sedation During Ultrasound-Guided High-Intensity Focused Ultrasound Ablation of Uterine Fibroids: A Prospective Dose-Finding Studyhttps://www.dovepress.com/ed50-and-ed95-of-remimazolam-combined-with-sufentanil-for-sedation-dur-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyMon, 29 Jun 2026 23:25:00 +1200https://doi.org/10.2147/DDDT.S526223Brain Endothelial Glycocalyx as a Blood-Facing Translational Interface in Alzheimer’s Disease: Beyond “Leaky” Barriers Toward Repair-First Stratificationhttps://www.dovepress.com/brain-endothelial-glycocalyx-as-a-blood-facing-translational-interface-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyFri, 26 Jun 2026 20:15:00 +1200https://doi.org/10.2147/DDDT.S619901Plumbagin Induces Ferroptosis in Nonfunctioning Pituitary Adenomas via Nrf2/FTH1-Dependent Ferritinophagyhttps://www.dovepress.com/plumbagin-induces-ferroptosis-in-nonfunctioning-pituitary-adenomas-via-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyFri, 26 Jun 2026 18:15:00 +1200https://doi.org/10.2147/DDDT.S564608Effect of Titrated Dexmedetomidine versus Esmolol on Postoperative Myocardial Injury in High-Risk Patients Undergoing Laparoscopic Colorectal Cancer Surgery: A Randomized Controlled Trialhttps://www.dovepress.com/effect-of-titrated-dexmedetomidine-versus-esmolol-on-postoperative-myo-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyFri, 26 Jun 2026 17:50:00 +1200https://doi.org/10.2147/DDDT.S602260A Review of Medicinal Plants from the Anak Dalam Tribe of Jambi: An Evaluation of Their Potential for Diabetic Wound Healing Effects—Current Status and Future Perspectiveshttps://www.dovepress.com/a-review-of-medicinal-plants-from-the-anak-dalam-tribe-of-jambi-an-eva-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyFri, 26 Jun 2026 00:10:00 +1200https://doi.org/10.2147/DDDT.S602665Clinical Impact of MeltDose Technology Extended-Release Tacrolimus (LCPT) in Solid Organ Transplantation: A Systematic Reviewhttps://www.dovepress.com/clinical-impact-of-meltdose-technology-extended-release-tacrolimus-lcp-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyThu, 25 Jun 2026 17:35:00 +1200https://doi.org/10.2147/DDDT.S613201Beyond Terminal Blockade: A Mechanism-Based Approach to Complement Inhibitor Selection in Paroxysmal Nocturnal Hemoglobinuriahttps://www.dovepress.com/beyond-terminal-blockade-a-mechanism-based-approach-to-complement-inhi-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyThu, 25 Jun 2026 12:40:00 +1200https://doi.org/10.2147/DDDT.S624829Interpreting Rituximab Response in Seronegative Membranous Nephropathy [Response to Letter]https://www.dovepress.com/interpreting-rituximab-response-in-seronegative-membranous-nephropat-2-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyThu, 25 Jun 2026 04:15:00 +1200https://doi.org/10.2147/DDDT.S631149Potential Hepatoprotective Effects of Adenosine Triphosphate Against Olaparib-Induced Oxidative Liver Injury: An Experimental Rat Modelhttps://www.dovepress.com/potential-hepatoprotective-effects-of-adenosine-triphosphate-against-o-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyWed, 24 Jun 2026 16:25:00 +1200https://doi.org/10.2147/DDDT.S613667Is Thoracic Paravertebral Block Truly Superior to Erector Spinae Plane Block? Re-Evaluating the Evidence from a Recovery Perspective [Letter]https://www.dovepress.com/is-thoracic-paravertebral-block-truly-superior-to-erector-spinae-plane-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyTue, 23 Jun 2026 15:50:00 +1200https://doi.org/10.2147/DDDT.S631849Granisetron Reduces Norepinephrine Requirement for Preventing Post‑Induction Hypotension in Elderly Patients Undergoing Laparoscopic Gastrointestinal Surgeryhttps://www.dovepress.com/granisetron-reduces-norepinephrine-requirement-for-preventing-postindu-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyTue, 23 Jun 2026 15:45:00 +1200https://doi.org/10.2147/DDDT.S609499Beyond Indication Expansion: Aligning Evidence, Reimbursement, and Access in Multi-Indication Oncology Drugs [Letter]https://www.dovepress.com/beyond-indication-expansion-aligning-evidence-reimbursement-and-access-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyTue, 23 Jun 2026 15:40:00 +1200https://doi.org/10.2147/DDDT.S625668Remodeling the Stroma: The Role of ncRNAs in Cancer-Associated Fibroblasts and Therapeutic Implications for Digestive Tumorshttps://www.dovepress.com/remodeling-the-stroma-the-role-of-ncrnas-in-cancer-associated-fibrobla-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyTue, 23 Jun 2026 15:30:00 +1200https://doi.org/10.2147/DDDT.S600029Swarm Intelligence in Drug Discovery Applications: Unlocking Deeper Insights on the Identification and Optimization of Potential Drug Candidateshttps://www.dovepress.com/swarm-intelligence-in-drug-discovery-applications-unlocking-deeper-ins-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyTue, 23 Jun 2026 15:25:00 +1200https://doi.org/10.2147/DDDT.S561251The Bonferroni Paradox: When Secondary Analyses are Held to a Stricter Standard Than the Primary Endpoint [Letter]https://www.dovepress.com/the-bonferroni-paradox-when-secondary-analyses-are-held-to-a-stricter--peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyTue, 23 Jun 2026 02:20:00 +1200https://doi.org/10.2147/DDDT.S633921Effects of Liposomal Bupivacaine for Superficial Parasternial Intercostal Plane Block on Postoperative Stress and Analgesia in Patients Undergoing Median Sternotomy: A Prospective, Randomized, Double-Blind Trialhttps://www.dovepress.com/effects-of-liposomal-bupivacaine-for-superficial-parasternial-intercos-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyMon, 22 Jun 2026 19:25:00 +1200https://doi.org/10.2147/DDDT.S597889Tubulin Post-Translational Modifications in Cardiovascular Diseases: Emerging Mechanisms and Therapeutic Modulation by Traditional Chinese Medicinehttps://www.dovepress.com/tubulin-post-translational-modifications-in-cardiovascular-diseases-em-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyMon, 22 Jun 2026 18:00:00 +1200https://doi.org/10.2147/DDDT.S616766