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Neuropsychiatric Disease and Treatment
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Investigating the Role of Ketamine and Its Enantiomers in Bipolar Depression
Bipolar depression (BD), affecting 2-3% of the global population, is a major research priority given the alarming suicide rates (5-10%) and a 30% non-response rate to existing treatments. The urgent need for innovative therapeutic strategies has led to interest in Ketamine and its enantiomers, including esketamine and arketamine, as potential options for BD treatment. However, robust evidence for ketamine's effectiveness in BD remains elusive, underscoring the necessity for thorough randomized studies, particularly those examining maintenance phase and long-term outcomes.