Nature and Science of Sleep

Bridging Bench to Bedside and Beyond: Advancing Sleep and Circadian Science for Precision Health Across All Ages

Sleep and circadian rhythms are fundamental to human health and well-being, influencing cognitive function, metabolic regulation, cardiovascular health, mental health, and immune function. Disruptions in sleep and circadian biology have been linked to a wide range of diseases, from neurodegenerative disorders and cardiometabolic conditions to mood disorders and impaired developmental trajectories in children. Yet, sleep and circadian health remain underutilized as modifiable targets in preventive medicine, clinical care, and public health initiatives. This Article Collection focuses on translational sleep and circadian health across the lifespan, highlighting research that spans developmental, clinical, and population health perspectives.