Journal of Inflammation Research

Multi-Layered Regulation of Inflammation: Integrating Non-Coding RNAs, Epigenomics, Single-Cell, and Spatial Transcriptomics

Inflammation is a critical physiological response, yet its dysregulation underlies numerous pathologies, including autoimmune diseases, metabolic disorders, cancer, and cardiovascular disorders. Traditional approaches to understanding inflammatory mechanisms have proven insufficient to capture the complexity of this multifaceted process. Recent advances have revealed that inflammation is orchestrated through multiple interconnected regulatory layers, extending far beyond protein-coding genes. This Article Collection includes contributions integrating these complementary approaches to elucidate novel regulatory mechanisms governing inflammation.