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Journal of Inflammation Research
Department of Oral Biology, College of Dentistry, The Ohio State University, United States
Editor-in-Chief: Professor Ning Quan
Dr. Quan is a Professor at the Ohio State University where he serves as a member of the Institute for Behavioral Medicine Research in the College of Medicine and Chairman of the Oral Biology PhD program in the College of Dentistry. During his PhD thesis research, he demonstrated a hypothermic effect of norepinephrine in the preoptic area of the hypothalamus. As a postdoctoral fellow at Duke University, he demonstrated the existence of IL-1 bioactivity in normal brain, linking this inflammatory cytokine to physiological neural functions of the central nervous system (CNS). During his research fellowship at the National Institute of Mental Health, He demonstrated that the blood brain barrier can serve as a relay of neuroimmune communication, transmitting peripheral immune signal to the brain.
Dr. Quan's past research at the Ohio State University focused on understanding the communication pathways between the immune system and the CNS and the neural functions of the mediators of neuroimmune communication. He demonstrated a role for proinflammatory cytokines in mediating neurodegeneration induced by the chronic CNS infection of Trypanosoma brucei, described the temporospatial distribution of IL-1 and COX-2 expression after peripheral immune challenge, uncovered a location-specific neural pathway by which localized peripheral inflammation signals brain, discovered multiple promoters in the IL-1R1 gene that drives cell type specific expression of IL-1R1 in the CNS to mediate diverse functions of IL-1 in the brain, leading to the identification of IL-1R3. His current research includes further dissecting the role of IL-1R1 and COX-2 in the brain by creating and analyzing mouse lines which express these molecules in specific cell types of the brain, elucidating mechanisms underlying a novel type of peripheral inflammation recently discovered in his lab-inflammation without the induction of sickness behaviors and neuroimmune activation, and exploring the potential clinical benefits of this type of inflammation.
At national and international levels, Dr. Quan has served as a member and chairman of multiple NIH study sections, a member of grant review panels for UK and Canada and on the editorial boards of multiple journals.
Salomon Amar, Provost for Biomedical Research/Chief Biomedical Research Officer, Touro College and University System; Professor of Pharmacology, Professor of Microbiology and Immunology, New York Medical College, Valhalla, NY, USA
Haydee E.P. Bazan, Professor, Department of Ophthalmology, LSU Health Science Center, LA, USA
J. Edwin Blalock, Ph.D., Professor, Department of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, University of Alabama at Birmingham, AL, USA
Michelle C. Callegan, Department of Ophthalmology, Microbiology/Immunology and Neuroscience, University of Oklahoma Health Sciences Center, OK, USA
Rupert Conrad, Head of Research, Department of Psychosomatic Medicine and Psychotherapy, Bonn University Hospital, Germany
Roberta B. Ness, Vice President for Innovation, University of Texas, Houston; James Rockwell Professor, School of Public Health, USA
Domenico Pratico, Department of Pharmacology, Temple University Health Sciences Center, PA, USA
P. Srirama Rao (Sriramarao), Professor, Departments of Medicine, Veterinary and Biomedical Sciences, University of Minnesota, MN, USA
Nancy H. Ruddle, Professor Emerita, Epidemiology of Microbial Diseases, Yale University School of Public Health, New Haven, CT, USA
Professor Van Goor
Harry van Goor, Department of Surgery, Radboud University Medical Centre, The Netherlands
Gary A. Weisman, Professor, Department of Biochemistry, University of Missouri-Columbia, MO, USA