Diabetes, Metabolic Syndrome and Obesity

Managing obesity with pharmacotherapy

Obesity is a chronic, relapsing, progressive disease causing or negatively impacting numerous medical conditions, including diabetes mellitus, cardiovascular disease, and some types of cancer. The foundation of its treatment is lifestyle modification. However, for many people with obesity, these changes are difficult to achieve and to maintain long-term. For this reason, great efforts have been made to develop effective drugs weight-reducing drugs. In the past, pharmacotherapy for obesity produced discouragingly modest weight loss on the whole, and several drugs had to be withdrawn from the market due to unacceptably severe side effects. However, the future of obesity pharmacotherapy looks promising. This Article Collection gathers studies in the area of pharmacological treatment of obesity, including preclinical studies, clinical trials, and reviews.