Breast Cancer: Targets and Therapy

ISSN: 1179-1314

Journal Articles:

Targeting Triple-Negative Breast Cancers: Modern Advancements and Future Directions

Triple negative breast cancer has historically been treated indiscriminately with chemotherapy based on the lack of known actionable alterations. The evolution of gene expression profiling, a greater understanding of the immune micro-environment, targeting of DNA damage repair pathways, and novel drug delivery methods have led to unprecedented advances in the management of triple negative breast cancer. Despite these advances, the prognosis for patients with advanced triple negative breast cancer remains limited, highlighting an urgent unmet need. This Article Collection summarizes the current treatment paradigms, novel treatment combinations and ongoing efforts seeking to overcome drug resistance in the advanced setting.

Clinical Trial Report

Does the Dose of Standard Adjuvant Chemotherapy Affect the Triple-negative Breast Cancer Benefit from Extended Capecitabine Metronomic Therapy? An Exploratory Analysis of the SYSUCC-001 Trial

Chen Y, Li WX, Wu JH, Chen GH, Yang CM, Lu H, Wang X, Wang SS, Huang H, Cai L, Zhao L, Peng RJ, Lin Y, Tang J, Zeng J, Zhang LH, Ke YL, Wang XM, Liu XM, Zhang AQ, Xu F, Bi XW, Huang JJ, Li JB, Pang DM, Xue C, Shi YX, He ZY, Lin HX, An X, Xia W, Cao Y, Guo Y, Hong RX, Jiang KK, Zhong YY, Zhang G, Tienchaiananda P, Oikawa M, Yuan ZY, Chen QJ

Breast Cancer: Targets and Therapy 2024, 16:223-231

Published Date: 12 April 2024

Review

Research Progress on Molecular Subtyping and Modern Treatment of Triple-Negative Breast Cancer

Tong L, Yu X, Wang S, Chen L, Wu Y

Breast Cancer: Targets and Therapy 2023, 15:647-658

Published Date: 24 August 2023

Original Research

Therapeutic Advantage of Targeting PRMT5 in Combination with Chemotherapies or EGFR/HER2 Inhibitors in Triple-Negative Breast Cancers

Dakroub R, Huard S, Hajj-Younes Y, Suresh S, Badran B, Fayyad-Kazan H, Dubois T

Breast Cancer: Targets and Therapy 2023, 15:785-799

Published Date: 6 November 2023