Back to Journals » International Journal of General Medicine » Pathophysiological Understanding of Rheumatic Fever and Rheumatic Heart Disease
International Journal of General Medicine
- View all (4895)
- Volume 19, 2026 (354)
- Volume 18, 2025 (621)
- Volume 17, 2024 (583)
- Volume 16, 2023 (542)
- Volume 15, 2022 (764)
- Volume 14, 2021 (991)
- Volume 13, 2020 (199)
- Volume 12, 2019 (62)
- Volume 11, 2018 (59)
- Volume 10, 2017 (56)
- Volume 9, 2016 (55)
- Volume 8, 2015 (54)
- Volume 7, 2014 (67)
- Volume 6, 2013 (119)
- Volume 5, 2012 (139)
- Volume 4, 2011 (125)
- Volume 3, 2010 (54)
- Volume 2, 2009 (35)
- Volume 1, 2008 (16)
Journal Articles:
- Today in Pulmonary Medicine from the Bench to Bedside and Beyond (2)
- Innovations and Integrations in regenerative medicine (1)
- Bridging the Digital Gap: Leveraging Metaverse Telehealth to Achieve Fair Access to Healthcare (1)
- Artificial Intelligence (AI) and the future of General Medicine (3)
- Impact of Dietary Choice on Life Expectancy – General Medicine Perspective in the Era of Longevity (1)
Pathophysiological Understanding of Rheumatic Fever and Rheumatic Heart Disease
RHD is an acquired heart valve disease, triggered by cross reactivity of anti-Group A streptococcal (GAS) antibodies with host proteins, whose protein epitopes mimic GAS antigenic epitopes. Anti-GAS antibodies have been experimentally cross reacted with myocardial sarcolemma proteins such as myosin, tropomyosin, intermediate filament vimentin and extracellular matrix (ECM) proteins, laminin which mimics the sequence of the N-Acetyl glucosamine, and group M peptide epitopes of GAS. This Collection pools together updated evidence and guide further research as per the NIH recommendations to eradicate RF and RHD.