Therapeutics and Clinical Risk Management

Novel Biomarkers and Molecular Biology of Solid Tumors

Solid tumors are biologically heterogeneous diseases shaped by dynamic interactions among genomic alterations, epigenetic states, transcriptional programs, the tumor microenvironment, and host factors. As a result, there is growing interest in biomarkers that can capture tumor behavior more accurately than conventional clinicopathologic variables alone. This Article Collection focuses on emerging biomarkers and molecular mechanisms relevant to solid tumors, spanning tissue-based and liquid-biopsy approaches, multi-omic profiling, and mechanistic studies that clarify how molecular alterations drive tumor initiation, progression, metastatic spread, and therapeutic response.