Therapeutics and Clinical Risk Management

Lymphoproliferation at the crossroad between hematology and immunology: molecular and clinical implications

Lymphoproliferation, clinically expressed with lymphadenopathies, hepato-splenomegaly, or lymphoid organ infiltration, is a common feature of different diseases, ranging from infections to hematologic malignancies. In the recent years, there has also been an increasing interest in the impact of lymphoproliferative features in patients with inborn errors of immunity (IEI), as benign polyclonal lymphoproliferation is one of the leading signs in different IEIs, including the autoimmune lymphoproliferative syndrome and other immune dysregulation disorders. Moreover, the knowledge on lymphoproliferative malignancies israpidly progressing, with the increasing availability of new therapeutic regimens.