OncoTargets and Therapy

Understand and target the complexity of the tumor milieu

The process of tumor initiation and progression is influenced by genetic/epigenetic alterations in tumor cells and the rearrangement of the tumor microenvironment (TME) through complex signaling networks. The TME consists of various components, including tumor cells, stromal fibroblasts, endothelial cells, immune cells, and extracellular matrix (ECM) components. Crosstalk between tumor cells and these non-malignant cells in the TME plays a critical role in promoting tumorigenesis, metastasis, and drug resistance. This Article Collection focuses on the molecular interactions between cancer cells and TME components, the link between tumor heterogeneity and metabolic plasticity, and related strategies that can bridge the gap between preclinical and clinical research.