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Idiopathic CD4 Lymphocytopenia: Current Insights

Authors Vijayakumar S, Viswanathan S, Aghoram R

Received 10 February 2020

Accepted for publication 10 April 2020

Published 14 May 2020 Volume 2020:9 Pages 79—93

DOI https://doi.org/10.2147/ITT.S214139

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Professor Michael Shurin


Saravanakumari Vijayakumar,1 Stalin Viswanathan,2 Rajeswari Aghoram3

1Pathology, Sri Lakshmi Narayana Institute of Medical Sciences, Pondicherry 605502, India; 2General Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry 605006, India; 3Department of Neurology, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry 605006, India

Correspondence: Rajeswari Aghoram
Department of Neurology, Jawaharlal Institute of Postgraduate Medical Education and Research, D. Nagar, Pondicherry 605006, India
Tel +91 413 229 7285
Email rajeswari.a@gmail.com

Abstract: Idiopathic CD4 lymphocytopenia is a condition characterized by low CD4 counts. It is rare and most of the information about this illness comes from case reports. Presentation is usually in the 4th decade of life with opportunistic infections, autoimmune disease or neoplasia. The pathophysiology of this condition is not well understood. Management revolves around treatment of the presenting condition and close follow-up of these patients. This review presents a narrative summary of the current literature on idiopathic CD4 lymphocytopenia.

Keywords: CD4 T cell lymphocytopenia, opportunistic infections, neoplasia, autoimmune disease

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