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The role of HIF-1α in chemo-/radioresistant tumors

Authors Xia Y, Jiang L, Zhong T

Received 27 November 2017

Accepted for publication 12 March 2018

Published 22 May 2018 Volume 2018:11 Pages 3003—3011

DOI https://doi.org/10.2147/OTT.S158206

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Justinn Cochran

Peer reviewer comments 2

Editor who approved publication: Dr Yao Dai


Yu Xia,1 Lixia Jiang,2 Tianyu Zhong2

1The Graduate School, Gannan Medical University, Ganzhou, People’s Republic of China; 2Department of Laboratory Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou, People’s Republic of China

Abstract: Chemo-/radioresistance is a major obstacle in clinical oncology. The precise failure mechanisms of chemo-/radioresistance are multifactorial failures. It is now widely accepted that a tumor hypoxia microenvironment contributes significantly to chemo-/radioresistance. Hypoxia is the most common and obvious neoplastic microenvironment and is due to the rapid proliferation of tumor cells. HIF-1α is a principal molecular mediator of adaptability to hypoxia in tumor cells. HIF-1α activation leads to the transcription of a plethora of target genes that promote physiological changes associated with chemo-/radioresistance, including increasing the ability of DNA repair, the inhibition of apoptosis, and alterations of the cellular metabolism. Moreover, recent findings suggest that HIF-1α-activated autophagy is a crucial factor in the promotion of cell survival under the distressed microenvironment, thereby leading to the chemo-/radioresistance. This chapter presents an overview of the role of HIF-1α in chemo-/radioresistance of tumor cells.

Keywords: HIF-1α, chemo-/radioresistance, cancer

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