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The Association Between Inflammation and Immunosuppression: Implications for ICI Biomarker Development

Authors Sacdalan DB, Lucero JA

Received 14 December 2020

Accepted for publication 25 February 2021

Published 18 March 2021 Volume 2021:14 Pages 2053—2064

DOI https://doi.org/10.2147/OTT.S278089

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Professor Gaetano Romano


Danielle Benedict Sacdalan,1,2 Josephine Anne Lucero3

1Department of Pharmacology and Toxicology, University of the Philippines Manila College of Medicine, Manila, Philippines; 2Division of Medical Oncology, Department of Medicine, Philippine General Hospital and University of the Philippines Manila, Manila, Philippines; 3Division of Hematology, Department of Medicine, Philippine General Hospital and University of the Philippines Manila, Manila, Philippines

Correspondence: Danielle Benedict Sacdalan Email [email protected]

Abstract: Evasion of immune destruction is considered one of the hallmarks of cancer. Chronic inflammation can enable immune escape by suppressing immune surveillance and permitting the development of tumors and creating a tumor microenvironment that sustains cancer. This includes generating mechanisms that prevent the effectiveness of anti-tumor treatment including immune checkpoint inhibitor therapy. In this review, we explore the interplay of inflammation and immunosuppression, their effects on the tumor microenvironment, and their implications for immune checkpoint inhibitor therapy particularly in the context of predictive biomarkers for their use.

Keywords: inflammation, immunosuppression, tumorigenesis, immune checkpoint inhibitor, biomarkers

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