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Strategies For Targeting Chronic Myeloid Leukaemia Stem Cells

Authors Carrà G, Cartellà A, Maffeo B, Morotti A

Received 27 August 2019

Accepted for publication 19 October 2019

Published 6 November 2019 Volume 2019:9 Pages 45—52

DOI https://doi.org/10.2147/BLCTT.S228815

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Professor David Dingli


Giovanna Carrà, Antonio Cartellà, Beatrice Maffeo, Alessandro Morotti

Department Of Clinical And Biological Sciences, University Of Turin, Orbassano 10043, Italy

Correspondence: Alessandro Morotti
Department Of Clinical And Biological Sciences, University Of Turin, Regione Gonzole 10, Orbassano 10043, Italy
Email alessandro.morotti@unito.it

Abstract: Chronic Myeloid Leukaemia is a myeloproliferative disorder driven by the t(9;22) chromosomal translocation coding for the chimeric protein BCR-ABL. CML treatment represents the paradigm of molecular therapy of cancer. Since the development of the tyrosine kinase inhibitor of the BCR-ABL kinase, the clinical approach to CML has dramatically changed, with a stunning improvement in the quality of life and response rates of patients. However, it remains clear that tyrosine kinase inhibitors (TKIs) are unable to target the most immature cellular component of CML, the CML stem cell. This review summarizes new insights into the mechanisms of resistance to TKIs.

Keywords: chronic myeloid leukaemia, stem cells, tyrosine kinase inhibitors

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