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Sex ratio of infants born to women with severe chronic constipation

Authors James W

Published 2 March 2011 Volume 2011:3(1) Pages 101—102


WH James
Department of Genetics, Evolution and Environment, University College London, London, UK
Czeizel et al1 reported a significant male excess among infants born to women with severe chronic constipation as contrasted with controls. Czeizel and colleagues were unable to account for this phenomenon, so I wish to suggest an explanation. Women (as contrasted with men) are disproportionately often affected by constipation, which is frequently aggravated by pregnancy and ameliorated after delivery,2 so it is reasonable to wonder whether constipation has hormonal causes. Large quantities of data have been adduced to support the hypothesis that the sex ratios (proportions male) of mammalian (including human) offspring are partially controlled by the hormone levels of both parents around the time of conception.3–5

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