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Serum CA125 Level Is Associated with Diabetic Retinopathy in Chinese Patients with Type 2 Diabetes

Authors Yao L, Zhong Y, He L, Wang Y, Wu J, Geng J, Zhou Y, Zhang J, Chen J, Shan Z, Teng W, Xu Y, Chen L, Liu L

Received 23 February 2020

Accepted for publication 7 May 2020

Published 22 May 2020 Volume 2020:13 Pages 1803—1812


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Dr Konstantinos Tziomalos

Litong Yao,1,2,* Yifan Zhong,3,* Lingzi He,1,* Yan Wang,4,* Jingyang Wu,3 Jin Geng,3 Yun Zhou,3 Jiahua Zhang,3 Jun Chen,3 Zhongyan Shan,5 Weiping Teng,5 Yingying Xu,2 Lei Chen,3 Lei Liu3

1China Medical University, Shenyang 110001, People’s Republic of China; 2Department of Breast Surgery, The First Hospital of China Medical University, Shenyang 110001, People’s Republic of China; 3Department of Ophthalmology, The First Hospital of China Medical University, Shenyang 110001, People’s Republic of China; 4Department of Radiology, General Hospital of Liaohe Oil Field, Panjin 124010, People’s Republic of China; 5Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, Shenyang 110001, People’s Republic of China

*These authors contributed equally to this work

Correspondence: Lei Chen; Lei Liu Email;

Background: To investigate the association between serum carbohydrate antigen 125 (CA125) and the presence as well as severity of diabetes retinopathy (DR) in Chinese adult patients with type 2 diabetes.
Methods: A hospital-based cross-sectional study was conducted from February 2012 to November 2018. DR was assessed using Early Treatment Diabetic Retinopathy Study criteria. Vision-threatening DR (VTDR) was diagnosed if subjects had severe non-proliferative DR (NPDR), proliferative DR (PDR), or clinically significant macular edema (CSME). Multivariate logistic regression models were applied to explore the associations.
Results: Among the 2696 participants, the overall prevalence of DR was 25.1%, of which the prevalence of mild NPDR, moderate NPDR, and VTDR was 10.8%, 4.5%, and 9.9%, respectively. Serum CA125 level was significantly higher in participants with DR and increased with the severity of DR (P = 0.013). After accounting for age, gender, smoking, drinking, duration of diabetes, anti-diabetic agents use, systolic blood pressure, pulse pressure, weight, hemoglobin A1c and fasting plasma glucose levels, CA125 level was significantly associated with subjects in any-severity DR (odds ratio [OR] 1.006 [95% confidence interval CI: 1.002– 1.010], P = 0.006) and VTDR (1.008 [1.003– 1.013], P = 0.001). When CA125 was treated as categorized variables, the prevalence of VTDR might increase as improving CA125 quartiles (P value for trend = 0.017).
Conclusion: In this study, serum CA125 level was associated with the presence and severity of DR in Chinese patients with type 2 diabetes. Further prospective studies should be warranted to validate the feasible role of CA125 as well as other biomarkers.

Keywords: type 2 diabetes, diabetes retinopathy, tumor biomarker, CA125, association

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