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Scrub typhus: risks, diagnostic issues, and management challenges

Authors Prakash JAJ

Received 23 December 2016

Accepted for publication 19 April 2017

Published 7 August 2017 Volume 2017:8 Pages 73—83

DOI https://doi.org/10.2147/RRTM.S105602

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Akshita Wason

Peer reviewer comments 3

Editor who approved publication: Dr Thomas Unnasch


John Antony Jude Prakash

Department of Clinical Microbiology, Christian Medical College, Vellore, Tamil Nadu, India

Abstract: Scrub typhus is an acute febrile illness in the “tsutsugamushi triangle”, transmitted by chiggers that can be treated effectively if detected early. Laboratory testing, including molecular and serological assays, is needed for confirming the diagnosis, especially in the absence of the pathognomonic eschar. In this review, factors that play a role in disease occurrence and clinical clues for diagnosis, in addition to risk factors contributing to disease severity, including mortality, are discussed in detail. Moreover, issues related to diagnostic assays, treatment, and mixed infections are also enumerated and described.

Keywords: Orientia tsutsugamushi, disease severity, mortality predictors, diagnosis, coinfections, treatment

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