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Roles of Wnt/β-Catenin Signaling Pathway Regulatory Long Non-Coding RNAs in the Pathogenesis of Non-Small Cell Lung Cancer

Authors Lin S, Zhen Y, Guan Y, Yi H

Received 8 December 2019

Accepted for publication 26 April 2020

Published 3 June 2020 Volume 2020:12 Pages 4181—4191


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 4

Editor who approved publication: Dr Beicheng Sun

Shan Lin,1– 3 Yu Zhen,4 Yinghui Guan,3 Huanfa Yi1,2

1Central Laboratory, The First Hospital of Jilin University, Changchun, Jilin, People’s Republic of China; 2Key Laboratory of Organ Regeneration and Transplantation, Ministry of Education, Changchun, Jilin 130021, People’s Republic of China; 3Department of Respiratory, The First Hospital of Jilin University, Changchun, Jilin, People’s Republic of China; 4Department of Dermatology, The First Hospital of Jilin University, Changchun, Jilin, People’s Republic of China

Correspondence: Huanfa Yi Email

Abstract: Lung cancer is one of the leading causes of cancer-related mortality worldwide. Non-small cell lung cancer (NSCLC) is the most common pathological type of lung cancer. Long non-coding RNAs (lncRNAs) are promising novel diagnostic and prognostic biomarkers, as well as potential therapeutic targets for lung cancer. Long non-coding RNAs (lncRNAs) have been demonstrated to modulate tumor cells proliferation, cell cycle progression, invasion, and metastasis by regulating gene expression at transcriptional, post-transcriptional, and epigenetic levels. The oncogenic aberrant Wnt/β-catenin signaling is prominent in lung cancer, playing a vital role in tumorigenesis, prognosis, and resistance to therapy. Interestingly, compelling studies have demonstrated that lncRNAs exert either oncogenic or tumor suppressor roles by regulating Wnt/β-catenin signaling. In this review, we aim to present the current accumulated knowledge regarding the roles of Wnt/β-catenin signaling-regulated lncRNAs in the pathogenesis of non-small cell lung cancer (NSCLC). Better understanding of the effects of lncRNAs on Wnt/β-catenin signaling might contribute to the improved understanding of the molecular tumor pathogenesis and to the uncovering of novel therapeutic targets in NSCLC.

Keywords: long non-coding RNA, lung cancer, non-small cell lung cancer, pathogenesis, Wnt/β-catenin signaling

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