Back to Journals » Cancer Management and Research » Volume 12

Roles of Wnt/β-Catenin Signaling Pathway Regulatory Long Non-Coding RNAs in the Pathogenesis of Non-Small Cell Lung Cancer

Authors Lin S, Zhen Y, Guan Y, Yi H

Received 8 December 2019

Accepted for publication 26 April 2020

Published 3 June 2020 Volume 2020:12 Pages 4181—4191

DOI https://doi.org/10.2147/CMAR.S241519

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 4

Editor who approved publication: Dr Beicheng Sun


Shan Lin,1– 3 Yu Zhen,4 Yinghui Guan,3 Huanfa Yi1,2

1Central Laboratory, The First Hospital of Jilin University, Changchun, Jilin, People’s Republic of China; 2Key Laboratory of Organ Regeneration and Transplantation, Ministry of Education, Changchun, Jilin 130021, People’s Republic of China; 3Department of Respiratory, The First Hospital of Jilin University, Changchun, Jilin, People’s Republic of China; 4Department of Dermatology, The First Hospital of Jilin University, Changchun, Jilin, People’s Republic of China

Correspondence: Huanfa Yi Email yihuanfa@jlu.edu.cn

Abstract: Lung cancer is one of the leading causes of cancer-related mortality worldwide. Non-small cell lung cancer (NSCLC) is the most common pathological type of lung cancer. Long non-coding RNAs (lncRNAs) are promising novel diagnostic and prognostic biomarkers, as well as potential therapeutic targets for lung cancer. Long non-coding RNAs (lncRNAs) have been demonstrated to modulate tumor cells proliferation, cell cycle progression, invasion, and metastasis by regulating gene expression at transcriptional, post-transcriptional, and epigenetic levels. The oncogenic aberrant Wnt/β-catenin signaling is prominent in lung cancer, playing a vital role in tumorigenesis, prognosis, and resistance to therapy. Interestingly, compelling studies have demonstrated that lncRNAs exert either oncogenic or tumor suppressor roles by regulating Wnt/β-catenin signaling. In this review, we aim to present the current accumulated knowledge regarding the roles of Wnt/β-catenin signaling-regulated lncRNAs in the pathogenesis of non-small cell lung cancer (NSCLC). Better understanding of the effects of lncRNAs on Wnt/β-catenin signaling might contribute to the improved understanding of the molecular tumor pathogenesis and to the uncovering of novel therapeutic targets in NSCLC.

Keywords: long non-coding RNA, lung cancer, non-small cell lung cancer, pathogenesis, Wnt/β-catenin signaling

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]