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Role of sleep quality in the metabolic syndrome

Authors Koren D, Dumin M, Gozal D

Received 8 June 2016

Accepted for publication 18 July 2016

Published 25 August 2016 Volume 2016:9 Pages 281—310


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Professor Ming-Hui Zou

Video abstract presented by Dorit Koren.

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Dorit Koren,1,2 Magdalena Dumin,1 David Gozal2,3

1Section of Adult and Pediatric Endocrinology, Diabetes, and Metabolism, Department of Medicine, 2Section of Pediatric Sleep Medicine, 3Section of Pulmonology, Department of Pediatrics, Pritzker School of Medicine, Biological Sciences Division, The University of Chicago, Chicago, IL, USA

Abstract: Emerging evidence has assigned an important role to sleep as a modulator of metabolic homeostasis. The impact of variations in sleep duration, sleep-disordered breathing, and chronotype to cardiometabolic function encompasses a wide array of perturbations spanning from obesity, insulin resistance, type 2 diabetes, the metabolic syndrome, and cardiovascular disease risk and mortality in both adults and children. Here, we critically and extensively review the published literature on such important issues and provide a comprehensive overview of the most salient pathophysiologic pathways underlying the links between sleep, sleep disorders, and cardiometabolic functioning.

Keywords: sleep apnea, circadian clock, insulin resistance, obesity, cardiovascular risk

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