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Role of Long Non-Coding RNAs in the Chemoresistance of Gastric Cancer: A Systematic Review

Authors Li Z, Lü M, Zhou Y, Xu L, Jiang Y, Liu Y, Li X, Song M

Received 27 November 2020

Accepted for publication 31 December 2020

Published 18 January 2021 Volume 2021:14 Pages 503—518

DOI https://doi.org/10.2147/OTT.S294378

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Dr Tohru Yamada


Zonglin Li,1 Muhan Lü,2 Yejiang Zhou,1 Linxia Xu,1 Yifan Jiang,1 Yi Liu,1 Xin Li,1 Min Song3

1Department of Gastrointestinal Surgery, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, People’s Republic of China; 2Department of Gastroenterology, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, People’s Republic of China; 3Department of Laboratory Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, People’s Republic of China

Correspondence: Min Song
Department of Laboratory Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, Sichuan, People’s Republic of China
Tel +8613982424099
Email songminlele2007@126.com

Purpose: Accumulating evidence demonstrates that long non-coding RNAs (lncRNAs) play a vital role in the chemoresistance of gastric cancer (GC). The present systematic review summarises the emerging role, potential targets or pathways and regulatory mechanisms of lncRNAs involved in chemoresistance and proposes a number of clinical implications of lncRNAs as novel therapeutic targets for GC.
Methods: Studies on lncRNAs involved in the chemoresistance of GC published until July 2020 in the PubMed and Web of Science databases were systematically reviewed and the expression form, role in chemoresistance, targets or pathways, corresponding drugs and potential mechanisms of relevant lncRNAs were summarised in detail.
Results: A total of 48 studies were included in this systematic review. Amongst these studies, 32 involved single drug resistance and 16 involved in multidrug resistance (MDR). The 48 studies collected described 38 lncRNAs in the drug-resistant cells of GC, including 33 upregulated and 5 downregulated lncRNAs. Cisplatin (DDP) was the most studied drug and lncRNA MALAT1 was the most studied lncRNA related to the chemoresistance of GC. The potential mechanisms of chemoresistance for lncRNAs in GC mainly included, amongst others, reduction of apoptosis, induction of autophagy, repair of DNA damage, promotion of epithelial–mesenchymal transition (EMT) and regulation of the related signalling pathways.
Conclusion: LncRNAs play a vital role in the chemoresistance of GC and are novel therapeutic targets for the disease. Detailed chemoresistance mechanisms, translational studies and clinical trials on lncRNAs in GC are urgently needed.

Keywords: gastric cancer, GC, long non-coding RNAs, lncRNAs, chemoresistance, multidrug resistance, MDR

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