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Risk of community-acquired pneumonia in chronic obstructive pulmonary disease stratified by smoking status: a population-based cohort study in the United Kingdom

Authors Braeken DCW, Rohde GGU, Franssen FME, Driessen JHM, van Staa TP, Souverein PC, Wouters EFM, de Vries F

Received 31 March 2017

Accepted for publication 18 May 2017

Published 14 August 2017 Volume 2017:12 Pages 2425—2432

DOI https://doi.org/10.2147/COPD.S138435

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Charles Downs

Peer reviewer comments 3

Editor who approved publication: Dr Richard Russell


Dionne CW Braeken,1–3 Gernot GU Rohde,2 Frits ME Franssen,1,2 Johanna HM Driessen,3–5 Tjeerd P van Staa,3,6 Patrick C Souverein,3 Emiel FM Wouters,1,2 Frank de Vries3,4,7

1Department of Research and Education, CIRO, Horn, 2Department of Respiratory Medicine, Maastricht University Medical Centre (MUMC+), Maastricht, 3Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute of Pharmaceutical Sciences, Utrecht, 4Department of Clinical Pharmacy and Toxicology, Maastricht University Medical Centre (MUMC+), Maastricht, 5Department of Epidemiology, Care and Public Health Research Institute (CAPHRI), Maastricht, the Netherlands; 6Department of Health eResearch, University of Manchester, Manchester, 7MRC Lifecourse Epidemiology Unit, Southampton General Hospital, Southampton, UK

Background: Smoking increases the risk of community-acquired pneumonia (CAP) and is associated with the development of COPD. Until now, it is unclear whether CAP in COPD is due to smoking-related effects, or due to COPD pathophysiology itself.
Objective: To evaluate the association between COPD and CAP by smoking status.
Methods: In total, 62,621 COPD and 191,654 control subjects, matched by year of birth, gender and primary care practice, were extracted from the Clinical Practice Research Datalink (2005–2014). Incidence rates (IRs) were estimated by dividing the total number of CAP cases by the cumulative person-time at risk. Time-varying Cox proportional hazard models were used to estimate the hazard ratios (HRs) for CAP in COPD patients versus controls. HRs of CAP by smoking status were calculated by stratified analyses in COPD patients versus controls and within both subgroups with never smoking as reference.
Results: IRs of CAP in COPD patients (32.00/1,000 person-years) and controls (6.75/1,000 person-years) increased with age and female gender. The risk of CAP in COPD patients was higher than in controls (HR 4.51, 95% CI: 4.27–4.77). Current smoking COPD patients had comparable CAP risk (HR 0.92, 95% CI: 0.82–1.02) as never smoking COPD patients (reference), whereas current smoking controls had a higher risk (HR 1.23, 95% CI: 1.13–1.34) compared to never smoking controls.
Conclusion: COPD patients have a fourfold increased risk to develop CAP, independent of smoking status. Identification of factors related with the increased risk of CAP in COPD is warranted, in order to improve the management of patients at risk.

Keywords: COPD, respiratory infections, incidence, smoking risk

A Letter to the Editor has been received and published for this article.

Introduction

Community-acquired pneumonia (CAP) is characterized by an acute infection of the pulmonary parenchyma with onset in the out-of-hospital setting.1 CAP incidence increases with age, smoking and the presence of comorbidities,1,2 varying between 1.5 and 11.0 per thousand adult population.3,4 In COPD, high incidence rates (IRs) of CAP, up to 22.4 per 1000 person-years, have been reported.5 Worse outcomes ie, higher mortality rates6,7 and longer length of hospital stay6 were observed, as well as more pronounced hypoxemia,7 hypercapnia,6,7 tachypnea6 and increased symptoms such as dyspnea and purulent sputum.7

Smoking individuals have a twofold increased CAP risk.1,4 Besides, smoking has been associated with increased susceptibility to infections in healthy subjects8 and COPD patients, triggering exacerbations.9 Until now, it is unclear whether CAP development in COPD is due to smoking-related increased susceptibility to infections, or due to COPD pathophysiology itself. Müllerova et al5 observed no association between current smoking and CAP incidence in COPD.

As smoking has been identified as a risk factor for both COPD and CAP, it is important to compare COPD patients to smoking and nonsmoking controls, to assess smoking-related effects, and distinguish possibly from additional risks associated with COPD and its pathophysiology. Particularly, it is important to take changes in smoking status over time into account, since smokers are known to undertake several attempts to quit smoking.10,11 Therefore, the aim of the present study was to evaluate the association between COPD and CAP by smoking status.

Methods

Source population

A population-based cohort study, with data derived from the world’s largest primary care database, Clinical Practice Research Datalink (CPRD), was conducted. CPRD contains computerized medical records of 674 primary care practices in the UK, collected since January 1987, representative for the total population.12 Coded data are collected on demographics, prescription details, clinical events, preventive care provided, tests, immunizations, specialist referrals, hospital admissions, discharge summaries and details regarding death.12 The period of data collection for the present study included the period in which the quality and outcomes framework (QOF) was effective (January 2005–January 2014).13 CPRD data have been widely used to study CAP,14,15 COPD16,17 and other respiratory diseases.18,19 CPRD data have been shown to be accurate and valid.20

Study population

Two cohorts were extracted. Cohort I: patients aged ≥40 years with a first ever recorded COPD read code, assigned by the general practitioner (see Supplementary materials, Table S1). COPD diagnosis defined start of follow-up (index date). Cohort II: randomly selected controls, without COPD diagnosis, matched by year of birth, gender and practice, using incidence density sampling. Controls were assigned the index date of their matched COPD patient. Controls with lung medication or lung function with Tiffenau index <0.7 before start of follow-up were excluded.21 From both cohorts, individuals with history of asthma, history of pneumonia 3 months prior to index date, active tuberculosis or use of tuberculosis medication and unknown smoking status were excluded.

Outcome

The primary outcome was physician-recorded pneumonia diagnosis, identified by read codes (Table S2). All patients were followed from index date to end of data collection, date of transfer out of the practice, patient’s death or outcome of interest, whichever came first. Follow-up time was divided into fixed intervals of 90 days.

Exposure of interest

Smoking status was determined prior to each interval (90-day) and stratified into three subcategories: never, current and former smoking. Smoking was defined by read codes (Table S3), which have provided valid estimates for the prevalence of current and never smoking.22 When the most recent smoking status was “never”, and the patient had quit smoking, his status was classified as former smoking.

Potential confounders

Potential confounders were time-dependently assessed, except for gender and body mass index (BMI). Time-dependent potential confounders were collected at the start of each time interval (90-day): age, history of pneumonia, cerebrovascular disease, dementia, malignancy (excluding nonmelanoma skin cancer), chronic renal disease, diabetes mellitus (use of insulin and/or blood glucose lowering medicines), cardiovascular diseases (heart failure, ischemic heart disease, coronary artery disease, myocardial infarction) and chronic liver disease. Moreover, proxies of the underlying severity of COPD, including number of exacerbations in the year before, and use of the following drugs 6 months before, were collected: short-acting beta-2 agonists, long-acting beta-2 agonists, inhaled corticosteroids, xanthine derivatives, short-acting inhaled anticholinergics, long-acting anticholinergics, cromoglycates, oxygen or systemic glucocorticoids.23 Analyses were adjusted for exposure to antipsychotics, acid suppressants or immunosuppressants in the past 6 months, as well as influenza or pneumococcal vaccination the year before. The most recent forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC) and Tiffenau index (ratio FEV1/FVC) were reviewed in the time frame ever before.

Statistical analysis

Data analyses were performed using SAS 9.3. IRs were estimated by dividing the total number of CAP cases by cumulative person-time at risk. Cox proportional hazard models estimated hazard ratios (HRs) of CAP in COPD patients versus controls. Analyses were stratified to gender, age and smoking status during follow-up.

Determinants of CAP within COPD were evaluated during follow-up: age, gender, smoking status and most recently recorded FEV1. HRs were estimated within each smoking status stratified for most recent level of airflow obstruction. HRs of CAP stratified by time-varying smoking status were assessed within COPD patients and controls separately. Never smoking was used as reference.

All analyses used time-varying Cox regression analysis. HRs were adjusted for gender and time-varying age and potential confounders (specified in previous section). Confounders were entered into the final model when independently changing the beta coefficient for current smoking by at least 5%, or when consensus was reached within the research team, supported by clinical evidence from literature. A test of interaction was performed to compare effects between the defined stratifications.24 The study protocol was approved by Independent Scientific Advisory Committee, 14_055.

Results

In total, 254,277 subjects were included in the present analysis (Figure 1). Of these, 62,621 had COPD. Table 1 describes baseline characteristics: almost half were female, mean age was 67 years, follow-up time on average was 3.6–4.0 years. At baseline, smoking status differed: COPD patients were frequently former or current smokers, while controls were more often never smokers. FEV1 data were available for <50% of COPD patients, most classified as mild-to-moderate airflow obstruction.

Figure 1 Flow chart.
Note: *Subjects can have more than one exclusion criteria.

Table 1 Baseline characteristics of patients with COPD and matched controls
Notes: Data are presented as mean ± SD or n (relative %). aIncluding: ischemic heart disease, myocardial infarction and coronary artery disease. bHistory of pneumonia >3 months prior to index date. cCOPD n=22, 985 (36.7%); matched controls n=4, 608 (2.4%).
Abbreviations: %pred, percentage of predicted; BMI, body mass index; FEV1, forced expiratory volume in 1 second; FVC, forced vital capacity; ICS, inhaled corticosteroids; LABAs, long-acting beta-2 agonists; LAMAs, long-acting muscarinic antagonists; SABAs, short-acting beta-2 agonists; SAMAs, short-acting muscarinic antagonists.

CAP incidence

Around 3.04% (n=7,730) of the total population was diagnosed with CAP during follow-up: 3,819 (6.10%) COPD patients and 3,911 (2.04%) controls. Table S4 shows IRs of CAP in COPD patients (32.00 per 1000 person-years) and controls (6.75 per 1000 person-years). IRs increased with age and female gender. In COPD patients, IR was highest in never smokers (39.51 per 1000 person-years), while former smokers had the lowest IR (28.31 per 1000 person-years). In controls, IR was highest in current smokers (7.82 per 1000 person-years).

CAP risk in COPD patients versus controls

COPD patients had a fourfold increased CAP risk compared to controls (fully adjusted [adj.] HR 4.51 [4.27–4.77]; Figure 2; Table S4). Stratum-specific CAP risk in COPD was significantly higher (test of interaction HR 1.22 [1.03–1.45]) in younger patients (aged 40–59; fully adj. HR 4.97 [4.40–5.62]), then in elderly patients (aged ≥80; fully adj. HR 4.08 [3.61–4.60]). After stratification to smoking status, the HR of CAP was five times higher in never smoking COPD patients, compared to never smoking controls (fully adj. HR 5.25 [4.75–5.80]). The same for current smoking COPD patients versus current smoking controls (fully adj. HR 4.94 [4.65–5.26]). Former smoking COPD patients had a fourfold increased CAP risk compared to former smoking controls (fully adj. HR 4.26 [4.00–4.55]).

Figure 2 Stratum-specific risk of CAP in patients with COPD compared to matched controls, stratified by age, gender and smoking status.
Notes: Adjusted for age, gender, BMI, antipsychotics, acid suppressants, immunosuppressants, influenza vaccination, pneumococcal vaccination, ICS, coronary artery disease, heart failure, diabetes mellitus, cerebrovascular disease, dementia, malignancy, chronic renal disease, chronic liver disease and smoking status.
Abbreviations: BMI, body mass index; CAP, community-acquired pneumonia; ICS, inhaled corticosteroids.

CAP risk and smoking status

Within COPD, CAP risk in current smokers (fully adj. HR 0.92 [0.82–1.02]) was comparable to the risk in never smokers (reference; Figure 3; Table S5). Former smoking COPD patients had a lower risk (fully adj. HR 0.81 [0.73–0.90]). Current smokers had a significantly higher CAP risk as compared to former smokers (P<0.001). CAP risk increased by older age (fully adj. HR aged 60–79, 2.26 [2.00–2.57]; aged ≥80, 6.06 [4.86–7.55]) and female gender (fully adj. HR 1.30 [1.22–1.39]). The level of airflow obstruction showed a trend toward increased CAP risk for very severe obstruction (fully adj. HR 1.30 [0.98–1.73]) in comparison to mild obstruction (reference). A subanalysis was performed by smoking status, stratified for level of airflow obstruction (Table S6). No clear trend of increased risk by severity of airflow obstruction was observed within never, current or former smokers.

Figure 3 Risk of CAP in patients with COPD, stratified by age, gender, smoking status and the level of airflow obstruction.
Notes: Adjusted for age, gender, BMI, antipsychotics, acid suppressants, immunosuppressants, influenza vaccination, pneumococcal vaccination, ICS, coronary artery disease, heart failure, diabetes mellitus, cerebrovascular disease, dementia, malignancy, chronic renal disease, chronic liver disease and smoking status.
Abbreviations: BMI, body mass index; CAP, community-acquired pneumonia; ICS, inhaled corticosteroids.

Within controls, CAP risk was highest in current smokers (fully adj. HR 1.23 [1.13–1.34]), while the risk in former smokers (fully adj. HR 1.07 [0.99–1.16]) was comparable with the risk in never smokers (reference; Table S7). Older age (fully adj. HR aged 60–79 years, 2.54 [2.23–2.90]; aged ≥80 years, 8.85 [7.10–11.00]) and female gender (fully adj. HR 1.26 [1.18–1.35]) showed increased CAP risk.

Discussion

COPD patients had a fourfold increased CAP risk in comparison with matched controls. Current smoking had no additional impact on CAP risk in COPD. In controls, CAP risk was elevated in current smokers. The risk of CAP increased in both COPD patients and controls with older age and female gender.

CAP risk and IRs

COPD patients had higher CAP IRs and increased CAP risk compared to controls, in line with former research.4,25 The observed IR in COPD patients was higher than reported by Müllerova et al5 (22.4/1000 person-years), but in accordance with the incidence reported by DiSantostefano et al (30.9/1000 person-years).26 In controls, Capelastegui et al27 observed an IR of 3.1/1000 adults per year, while our observed IR was twice as high (6.8/1000 person-years). A possible explanation of the higher IRs observed, might be the rising incidence in European countries.28 A number of factors are associated with this phenomenon: populations grow older, and lifestyle factors and comorbid conditions related to CAP become more prevalent.28 Older age might also be a potential factor in our study, as the average age was 67 years. This was also shown by Millett et al29 with an incidence of 8.0/1000 person-years in controls ≥65 years old.

Gender differences appeared, as females had a slightly larger CAP risk than males. This is in contrast with former research.2,30,31 Reasons for increased risk in females could not be further delineated in this study, but clearly warrant further research. Changes in female lifestyle and risk behavior have been reported in previous decades and might represent important factors.32,33 Furthermore, former research showed that respiratory symptoms were more often reported by females than males,34 with higher hospitalization incidences in studies concerning milder CAP cases.35,36

Smoking status and CAP risk

Current smoking was associated with increased CAP risk in controls, in line with former research.3739 Smoking has been related to structural changes in the respiratory tract and a decrease in immune response,40 which might result in microbial invasion of the bronchial tree, triggering CAP.

In COPD patients, CAP risk was comparable between never and current smokers. It was expected that, in accordance with controls, current smokers were at increased CAP risk. However, Müllerova et al5 also observed no difference in CAP risk between nonsmoking and current smoking COPD patients. Moreover, Myint et al41 observed a larger proportion of current smokers in COPD without CAP than in CAP–COPD. Maybe, inaccurate recording of smoking status by general practitioners influenced the present results, although smoking is a QOF indicator, rewarding general practitioners to record patients’ smoking status every year when diagnosed with COPD. However, smoking is the major risk factor of COPD, but the majority of persistent smokers do not develop COPD. This suggests that the vulnerability to cigarette smoke varies between individuals. The mechanisms behind this are at the moment not completely understood.42 Never smokers may also develop COPD, but by a different pathway than exposure to smoking,43 for example, by occupational/environmental exposures, alpha-1-antitrypsin deficiency or due to factors early in life which affect the respiratory health in the long-term.44 Pathophysiological differences between subgroups of COPD might contribute to the observed differences in CAP risk. Besides, it is likely that a combination of factors is responsible for disease development, or not. For example, smoking has been associated with CAP development, but is also associated with a lower socioeconomic status, poor diet, alcohol consumption and reduced physical activity,45 which, in turn, are also risk factors for CAP.4 Furthermore, there are theoretically three general mechanisms related to the increased CAP risk of smoking: 1) tobacco-induced physiological and structural changes, 2) tobacco-induced increase in bacterial virulence, 3) tobacco-induced dysregulation of immune function.8 These three mechanisms are also key features in COPD, and probably the smoking-effect related to both the development of CAP and COPD, does not sum-up. Overall, many mechanisms might be associated with the observed results, but further research is warranted to explore exact pathways involved.

We also observed no difference concerning severity of airflow obstruction stratified by smoking status and CAP risk. IRs increased with worse airflow obstruction, but only showing a trend toward increased risk in very severe airflow obstruction. Conflicting results were reported before, some observing increased CAP risk in severe and very severe airflow obstruction,46 while others observed no difference in CAP risk by airflow obstruction.41 There may be reverse causation underlying this lack of relationship; those with worse airflow obstruction stopped smoking, while others continued their smoking habits. However, this is less likely, as smoking status over time was taken into account, correcting for possible confounding. Furthermore, never and current smoking COPD patients had a comparable risk, which stresses the fact that the observed results are not due to smoking cessation.

Strengths and limitations

The current study includes a large population-based cohort study, providing anonymous longitudinal medical records of primary care patients.12,47 This study design makes the current results generalizable to a larger population. In addition, by taking smoking status over time into account, the results are representative of real life setting.

In contrast, several methodological issues could have influenced the results. First, primary care databases rely on the quality of information included in records.12 This depends on the accuracy of individuals responsible for entering data. However, inclusion of a large number of patients will minimize potential bias. Second, we did not use spirometry to confirm COPD diagnosis, as this was available for only one-third of patients. Misclassification of exposure is likely to be nondifferential and may have led to a bias toward null.48 This implies that the fourfold increased risk of CAP in COPD versus non-COPD may have been underestimated. In addition, CAP diagnosis was not confirmed by chest X-ray, but based on clinical features, probably causing CAP overestimation.49 This may have led to a nondifferential misclassification of the outcome and a bias toward the null value. However, it has a small impact on our main findings: the true HR of CAP among smokers versus nonsmokers in COPD would have been lower than the nonsignificant 8% reduced risk, and will still not support our main hypothesis that smoking increases the risk of CAP in COPD. In addition, ICS use was not separately analyzed, but only included as a potential confounder, as this would go beyond the primary aim of the objective. However, ICS risk in CAP is of high interest, often showing an increased risk, although probably depending on the specific ICS and dose.50

Clinical implications

The results of the present analyses highlight the fact that CAP remains a major health issue, impacting both socially and economically.51 Smoking cessation is an important aspect in the management of CAP and especially in control subjects, this strategy might be beneficial and lead to a decreased risk to develop CAP.38 In contrast, for patients with COPD, this association seems less clear, but as earlier described, further research is necessary to assess mechanisms associated with the increased risk to develop CAP. For clinical practice it remains important to not underestimate the impact of CAP in patients with COPD. The management of CAP is at the moment focused on treating the disease, and prevention by vaccination,51 while prevention of lifestyle factors, such as smoking, alcohol consumption and bodyweight, is at least as important.4,38,39,52,53

Conclusion

COPD patients have a fourfold increased risk to develop CAP, independent of smoking status. Identification of factors related with the increased risk of CAP in COPD is warranted, in order to improve the management of patients at risk.

Acknowledgments

The abstract of this manuscript was presented as an oral presentation during the conference of the European Respiratory Society in September 2016 in London. The abstract was published in the “ERS International Congress 2016 Abstracts” (http://erj.ersjournals.com/content/48/suppl_60/OA1504).

Disclosure

The authors report no conflicts of interest in this work.


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