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Upregulated pneumococcal adhesion molecule (platelet-activating factor receptor) may predispose COPD patients to community-acquired pneumonia

Authors Shukla SD, Hansbro PM, Walters EH

Received 7 September 2017

Accepted for publication 25 September 2017

Published 24 October 2017 Volume 2017:12 Pages 3111—3113

DOI https://doi.org/10.2147/COPD.S151142

Checked for plagiarism Yes

Editor who approved publication: Dr Richard Russell


Shakti Dhar Shukla,1,2 Philip M Hansbro,1,2 Eugene Haydn Walters3

1School of Biomedical Sciences and Pharmacy, The University of Newcastle, Callaghan, 2Hunter Medical Research Institute, New Lambton Heights, NSW, 3School of Medicine, University of Tasmania, Hobart, TAS, Australia

We read with great interest the recent paper by Braeken et al which analyzed the associations between COPD and community-acquired pneumonia (CAP), published in your journal.1 In this large population-based study, the authors have concluded that the risk of CAP increases fourfold in patients with COPD, independent of smoking status. The authors briefly discuss potential smoking-induced mechanisms leading to increased risk of CAP in COPD, such as host physiological and structural changes, increased bacterial virulence and impaired host immunity. The authors also stress the need for further mechanistic studies on the cause of this increased risk of CAP in COPD patients.1

Authors’ reply

Frank de Vries,1,2 Gernot GU Rohde,3,4 Dionne CW Braeken,1,4,5 Tjeerd P van Staa,1,6 Patrick C Souverein,1 Emiel FM Wouters,4,5 Frits ME Franssen4,5
1Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht, 2Department of Clinical Pharmacy and Toxicology, Maastricht University Medical Centre (MUMC+), Maastricht, the Netherlands; 3Klinikum der Johann Wolfgang Goethe-Universität, Frankfurt am Main, Germany; 4Department of Respiratory Medicine, Maastricht University Medical Centre (MUMC+), Maastricht, 5Department of Research and Education, CIRO, Horn, the Netherlands; 6Department of Health eResearch, University of Manchester, Manchester, UK
We would like to thank Shukla et al for their interesting and valuable addition to our study, which showed that the risk of community-acquired pneumonia (CAP) was fourfold increased among patients with COPD, regardless of their smoking status.1 They first speculate that their observation of expression of adhesion molecules (PAFr) in several bacteria that can cause CAP among COPD patients may explain our findings. Although they observed a significantly increased expression of PAFr among smokers with COPD versus smokers with a normal lung function, PAFr expression was not elevated among COPD patients who were ex-smokers.2
View the original paper by Braeken and colleagues. 

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