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Real-World Experience with Lifitegrast Ophthalmic Solution (Xiidra®) in the US and Canada: Retrospective Study of Patient Characteristics, Treatment Patterns, and Clinical Effectiveness in 600 Patients with Dry Eye Disease

Authors Hovanesian JA, Nichols KK, Jackson M, Katz J, Chan A, Glassberg MB, Sloesen B, Korves C, Nguyen C, Syntosi A

Received 18 December 2020

Accepted for publication 3 February 2021

Published 8 March 2021 Volume 2021:15 Pages 1041—1054


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Scott Fraser

John A Hovanesian,1,2 Kelly K Nichols,3 Mitchell Jackson,4 James Katz,5 Arthur Chan,6 Mrudula B Glassberg,6 Brigitte Sloesen,7 Caroline Korves,8 Catherine Nguyen,9 Annie Syntosi7

1Harvard Eye Associates, Laguna Hills, CA, USA; 2UCLA Jules Stein Eye Institute, Los Angeles, CA, USA; 3School of Optometry, University of Alabama at Birmingham, Birmingham, AL, USA; 4Jacksoneye, Lake Villa, IL, USA; 5The Midwest Center for Sight, Des Plaines, IL, USA; 6Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA; 7Novartis Pharma AG, Basel, Switzerland; 8Analysis Group, Inc., Boston, MA, USA; 9Analysis Group, Inc., Los Angeles, CA, USA

Correspondence: Annie Syntosi
Retina Global Patient Access, Novartis Campus, Lichtstrasse 35, Basel, 4056, Switzerland
Tel +41 763785855
Email [email protected]

Purpose: This study evaluated real-world treatment of dry eye disease (DED) with lifitegrast.
Patients and Methods: Ophthalmologists and optometrists treating patients with DED were invited to participate through a healthcare provider (HCP)-based panel. HCPs completed a provider survey and contributed data toward a chart review for up to five qualifying patients with DED who initiated lifitegrast ophthalmic solution (index date) between 01/01/2017 (US) or 01/01/2018 (Canada) and 06/30/2019. Patient demographics, treatments, clinical characteristics, and outcomes (ie, severity, signs, symptoms) were collected for the 6-month pre-index period and up to 12-months post-index.
Results: For this study, 517 HCPs contributed 600 patient charts. Among 554 and 281 patients with follow-up at 6 and 12-months post-index, 512 (92.4%) and 238 (84.7%) patients had ongoing lifitegrast treatment, respectively. Other DED-related treatments were less frequently used post-index with lifitegrast vs pre-index: over-the-counter artificial tear use (45.2% vs 75.5%), topical corticosteroids (3.8% vs 18.8%), any cyclosporine (3.0% vs 20.5%). At 3-months (n=571) and 12-months (n=320) post-index vs pre-index, fewer patients had eye dryness (47 [8.2%] and 16 [5.0%] vs 525 [87.5%]), blurred vision (28 [4.9%] and 11 [3.4%] vs 346 [57.7%]), ocular burning/stinging (25 [4.4%] and 8 [2.5%] vs 336 [56.0%]), depression (8 [1.4%] and 9 [2.8%] vs 55 [9.2%]), fatigue (4 [0.7%] and 1 [0.3%] vs 82 [13.7%]), and headache (1 [0.2%] and 0 vs 19 [3.2%]). At 3 and 12-months post-index vs pre-index, average corneal staining score was numerically lower (2.7 and 2.0 vs 6.5), and average Schirmer score (10.6 and 10 vs 6.3) and tear film break-up time (7.3 and 8.0 vs 4.8) higher.
Conclusion: The majority of patients had ongoing lifitegrast treatment 6-months post-index with reduction in overall treatment burden. Improvement in DED signs and symptoms, including QoL impacts, was evident at 3 months and up to 12 months after lifitegrast initiation.

Keywords: symptoms, signs, severity, QoL

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